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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
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Results for NKX2-3
Z-value: 0.35
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Transcription factors associated with NKX2-3
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr5_+_150404904 Show fit | 32.59 |
ENST00000521632.1
|
glutathione peroxidase 3 (plasma) |
|
| chr4_-_84035868 Show fit | 7.69 |
ENST00000426923.2
ENST00000509973.1 |
placenta-specific 8 |
|
| chr4_-_84035905 Show fit | 7.56 |
ENST00000311507.4
|
placenta-specific 8 |
|
| chr11_+_10326612 Show fit | 5.28 |
ENST00000534464.1
ENST00000530439.1 ENST00000524948.1 ENST00000528655.1 ENST00000526492.1 ENST00000525063.1 |
adrenomedullin |
|
| chr17_-_76870222 Show fit | 5.04 |
ENST00000585421.1
|
TIMP metallopeptidase inhibitor 2 |
|
| chr17_-_76870126 Show fit | 4.96 |
ENST00000586057.1
|
TIMP metallopeptidase inhibitor 2 |
|
| chr11_+_35211429 Show fit | 4.64 |
ENST00000525688.1
ENST00000278385.6 ENST00000533222.1 |
CD44 molecule (Indian blood group) |
|
| chr3_-_123512688 Show fit | 4.31 |
ENST00000475616.1
|
myosin light chain kinase |
|
| chr17_-_8055747 Show fit | 4.24 |
ENST00000317276.4
ENST00000581703.1 |
period circadian clock 1 |
|
| chr9_-_137809718 Show fit | 4.16 |
ENST00000371806.3
|
ficolin (collagen/fibrinogen domain containing) 1 |
Network of associatons between targets according to the STRING database.
First level regulatory network of NKX2-3
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 10.9 | 32.6 | GO:0006982 | response to lipid hydroperoxide(GO:0006982) |
| 0.9 | 17.0 | GO:0040015 | negative regulation of multicellular organism growth(GO:0040015) |
| 2.0 | 10.0 | GO:0032487 | regulation of Rap protein signal transduction(GO:0032487) |
| 1.0 | 7.8 | GO:1900623 | regulation of monocyte aggregation(GO:1900623) positive regulation of monocyte aggregation(GO:1900625) |
| 0.0 | 7.1 | GO:0043312 | neutrophil activation involved in immune response(GO:0002283) neutrophil degranulation(GO:0043312) |
| 0.6 | 5.8 | GO:0006069 | ethanol oxidation(GO:0006069) |
| 1.9 | 5.6 | GO:0002514 | B cell tolerance induction(GO:0002514) regulation of B cell tolerance induction(GO:0002661) positive regulation of B cell tolerance induction(GO:0002663) |
| 1.1 | 5.3 | GO:0045906 | negative regulation of vasoconstriction(GO:0045906) |
| 0.4 | 4.9 | GO:0070129 | regulation of mitochondrial translation(GO:0070129) |
| 0.5 | 4.3 | GO:0060414 | aorta smooth muscle tissue morphogenesis(GO:0060414) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 41.0 | GO:0005615 | extracellular space(GO:0005615) |
| 0.2 | 16.8 | GO:0035578 | azurophil granule lumen(GO:0035578) |
| 0.1 | 10.0 | GO:0035580 | specific granule lumen(GO:0035580) |
| 0.0 | 8.9 | GO:0005925 | focal adhesion(GO:0005925) |
| 1.1 | 7.8 | GO:0035692 | macrophage migration inhibitory factor receptor complex(GO:0035692) |
| 0.4 | 6.4 | GO:0045277 | respiratory chain complex IV(GO:0045277) |
| 0.6 | 5.6 | GO:0070022 | transforming growth factor beta receptor homodimeric complex(GO:0070022) |
| 0.1 | 4.3 | GO:0097610 | cleavage furrow(GO:0032154) cell surface furrow(GO:0097610) |
| 0.7 | 4.2 | GO:0031232 | extrinsic component of external side of plasma membrane(GO:0031232) |
| 0.0 | 4.2 | GO:0009897 | external side of plasma membrane(GO:0009897) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.3 | 36.1 | GO:0008430 | selenium binding(GO:0008430) |
| 0.0 | 16.1 | GO:0003682 | chromatin binding(GO:0003682) |
| 0.5 | 12.0 | GO:0008191 | metalloendopeptidase inhibitor activity(GO:0008191) |
| 0.1 | 8.0 | GO:0005179 | hormone activity(GO:0005179) |
| 0.0 | 7.5 | GO:0004930 | G-protein coupled receptor activity(GO:0004930) |
| 0.2 | 7.2 | GO:0005540 | hyaluronic acid binding(GO:0005540) |
| 0.5 | 6.9 | GO:0033691 | sialic acid binding(GO:0033691) |
| 0.0 | 6.2 | GO:0017137 | Rab GTPase binding(GO:0017137) |
| 1.0 | 5.8 | GO:0004024 | alcohol dehydrogenase activity, zinc-dependent(GO:0004024) |
| 1.4 | 5.6 | GO:0005026 | transforming growth factor beta receptor activity, type II(GO:0005026) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 8.1 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.2 | 7.8 | SA MMP CYTOKINE CONNECTION | Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. |
| 0.0 | 6.9 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.1 | 6.5 | PID HIF1 TFPATHWAY | HIF-1-alpha transcription factor network |
| 0.1 | 5.2 | PID ALK1 PATHWAY | ALK1 signaling events |
| 0.1 | 5.2 | SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES | Genes related to regulation of the actin cytoskeleton |
| 0.0 | 4.3 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.2 | 4.2 | PID CIRCADIAN PATHWAY | Circadian rhythm pathway |
| 0.1 | 3.3 | SA B CELL RECEPTOR COMPLEXES | Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases. |
| 0.1 | 2.9 | PID EPHRINB REV PATHWAY | Ephrin B reverse signaling |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 10.4 | REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX | Genes involved in Degradation of the extracellular matrix |
| 0.1 | 9.9 | REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS | Genes involved in Class B/2 (Secretin family receptors) |
| 0.4 | 7.8 | REACTOME HYALURONAN UPTAKE AND DEGRADATION | Genes involved in Hyaluronan uptake and degradation |
| 0.0 | 7.8 | REACTOME G ALPHA I SIGNALLING EVENTS | Genes involved in G alpha (i) signalling events |
| 0.1 | 6.4 | REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION | Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression |
| 0.7 | 5.8 | REACTOME ETHANOL OXIDATION | Genes involved in Ethanol oxidation |
| 0.2 | 5.6 | REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION | Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) |
| 0.0 | 4.2 | REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL | Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
| 0.1 | 3.5 | REACTOME AMINE DERIVED HORMONES | Genes involved in Amine-derived hormones |
| 0.1 | 3.3 | REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS | Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs) |