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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)

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Results for RORA

Z-value: 1.35

Motif logo

Transcription factors associated with RORA

Gene Symbol Gene ID Gene Info
ENSG00000069667.11 RAR related orphan receptor A

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
RORAhg19_v2_chr15_-_60884706_60884743,
hg19_v2_chr15_-_61521495_61521518
-0.054.6e-01Click!

Activity profile of RORA motif

Sorted Z-values of RORA motif

Promoter Log-likelihood Transcript Gene Gene Info
chr20_+_3776371 30.51 ENST00000245960.5
cell division cycle 25B
chr20_+_3776936 29.46 ENST00000439880.2
cell division cycle 25B
chr16_-_88717423 27.08 ENST00000568278.1
ENST00000569359.1
ENST00000567174.1
cytochrome b-245, alpha polypeptide
chr1_+_43148625 25.26 ENST00000436427.1
Y box binding protein 1
chr14_-_58893832 22.30 ENST00000556007.2
translocase of inner mitochondrial membrane 9 homolog (yeast)
chr7_+_112063192 20.89 ENST00000005558.4
interferon-related developmental regulator 1
chr1_-_150207017 20.17 ENST00000369119.3
acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
chr6_-_41039567 19.49 ENST00000468811.1
O-acyl-ADP-ribose deacylase 1
chr12_-_53320245 19.47 ENST00000552150.1
keratin 8
chr9_-_35103105 19.40 ENST00000452248.2
ENST00000356493.5
stomatin (EPB72)-like 2
chr1_-_153522562 18.55 ENST00000368714.1
S100 calcium binding protein A4
chr17_+_49230897 17.57 ENST00000393196.3
ENST00000336097.3
ENST00000480143.1
ENST00000511355.1
ENST00000013034.3
ENST00000393198.3
ENST00000608447.1
ENST00000393193.2
ENST00000376392.6
ENST00000555572.1
NME/NM23 nucleoside diphosphate kinase 1
NME1-NME2 readthrough
NME/NM23 nucleoside diphosphate kinase 2
chr7_+_128399002 17.27 ENST00000493278.1
calumenin
chr10_+_94050913 15.99 ENST00000358935.2
membrane-associated ring finger (C3HC4) 5
chr10_-_65028817 15.43 ENST00000542921.1
jumonji domain containing 1C
chrX_-_129299638 15.31 ENST00000535724.1
ENST00000346424.2
apoptosis-inducing factor, mitochondrion-associated, 1
chr10_+_81107271 14.43 ENST00000448165.1
peptidylprolyl isomerase F
chr14_-_102552659 13.95 ENST00000441629.2
heat shock protein 90kDa alpha (cytosolic), class A member 1
chr2_+_198365122 13.49 ENST00000604458.1
HSPE1-MOB4 readthrough
chr3_-_113465065 13.11 ENST00000497255.1
ENST00000478020.1
ENST00000240922.3
ENST00000493900.1
N(alpha)-acetyltransferase 50, NatE catalytic subunit
chr7_-_140179276 13.06 ENST00000443720.2
ENST00000255977.2
makorin ring finger protein 1
chr9_-_130966497 12.88 ENST00000393608.1
ENST00000372948.3
CDKN1A interacting zinc finger protein 1
chr1_-_211752073 12.78 ENST00000367001.4
solute carrier family 30 (zinc transporter), member 1
chr18_-_19284724 11.82 ENST00000580981.1
ENST00000289119.2
abhydrolase domain containing 3
chr19_-_39826639 11.73 ENST00000602185.1
ENST00000598034.1
ENST00000601387.1
ENST00000595636.1
ENST00000253054.8
ENST00000594700.1
ENST00000597595.1
glia maturation factor, gamma
chr7_-_25164969 11.63 ENST00000305786.2
cytochrome c, somatic
chr21_-_46330545 11.45 ENST00000320216.6
ENST00000397852.1
integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
chr16_+_21964662 11.41 ENST00000561553.1
ENST00000565331.1
ubiquinol-cytochrome c reductase core protein II
chr2_-_86422095 10.99 ENST00000254636.5
inner membrane protein, mitochondrial
chr11_+_118272328 10.91 ENST00000524422.1
ATP synthase, H+ transporting, mitochondrial Fo complex, subunit G
chr2_+_198365095 10.77 ENST00000409468.1
heat shock 10kDa protein 1
chr3_-_141747950 10.14 ENST00000497579.1
transcription factor Dp-2 (E2F dimerization partner 2)
chr2_-_209118974 10.00 ENST00000415913.1
ENST00000415282.1
ENST00000446179.1
isocitrate dehydrogenase 1 (NADP+), soluble
chr3_+_179322573 9.97 ENST00000493866.1
ENST00000472629.1
ENST00000482604.1
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 5, 16kDa
chr9_+_134103496 9.54 ENST00000498010.1
ENST00000476004.1
ENST00000528406.1
nucleoporin 214kDa
chr1_-_33502528 9.32 ENST00000354858.6
adenylate kinase 2
chr1_-_32403903 9.21 ENST00000344035.6
ENST00000356536.3
protein tyrosine phosphatase type IVA, member 2
chr16_-_47177874 9.16 ENST00000562435.1
neuropilin (NRP) and tolloid (TLL)-like 2
chr10_-_103578182 8.99 ENST00000439817.1
meningioma expressed antigen 5 (hyaluronidase)
chr1_-_33502441 8.81 ENST00000548033.1
ENST00000487289.1
ENST00000373449.2
ENST00000480134.1
ENST00000467905.1
adenylate kinase 2
chr1_-_205719295 8.67 ENST00000367142.4
nuclear casein kinase and cyclin-dependent kinase substrate 1
chr2_-_207024134 8.63 ENST00000457011.1
ENST00000440274.1
ENST00000432169.1
NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa (NADH-coenzyme Q reductase)
chr17_-_42144949 8.59 ENST00000591247.1
LSM12 homolog (S. cerevisiae)
chr5_-_140027175 8.44 ENST00000512088.1
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 2, 8kDa
chr10_-_103578162 8.30 ENST00000361464.3
ENST00000357797.5
ENST00000370094.3
meningioma expressed antigen 5 (hyaluronidase)
chr1_+_206858328 8.05 ENST00000367103.3
mitogen-activated protein kinase-activated protein kinase 2
chr11_-_64511575 7.45 ENST00000431822.1
ENST00000377486.3
ENST00000394432.3
RAS guanyl releasing protein 2 (calcium and DAG-regulated)
chr7_-_107642348 7.30 ENST00000393561.1
laminin, beta 1
chr2_+_207024306 7.23 ENST00000236957.5
ENST00000392221.1
ENST00000392222.2
ENST00000445505.1
eukaryotic translation elongation factor 1 beta 2
chr19_-_39926268 7.19 ENST00000599705.1
ribosomal protein S16
chr12_-_6484376 7.17 ENST00000360168.3
ENST00000358945.3
sodium channel, non-voltage-gated 1 alpha subunit
chr2_+_109237717 6.68 ENST00000409441.1
LIM and senescent cell antigen-like domains 1
chr10_-_65028938 6.63 ENST00000402544.1
jumonji domain containing 1C
chrX_+_153770421 6.61 ENST00000369609.5
ENST00000369607.1
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma
chr17_-_48785216 6.59 ENST00000285243.6
ankyrin repeat domain 40
chr7_-_45151272 6.46 ENST00000461363.1
ENST00000495078.1
ENST00000494076.1
ENST00000478532.1
ENST00000258770.3
ENST00000361278.3
transforming growth factor beta regulator 4
chr1_+_43148059 6.21 ENST00000321358.7
ENST00000332220.6
Y box binding protein 1
chr10_+_72575643 6.19 ENST00000373202.3
sphingosine-1-phosphate lyase 1
chr5_+_140027355 6.17 ENST00000417647.2
ENST00000507593.1
ENST00000508301.1
IK cytokine, down-regulator of HLA II
chr7_-_123197733 6.16 ENST00000470123.1
ENST00000471770.1
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 5
chr7_-_127983877 5.96 ENST00000415472.2
ENST00000478061.1
ENST00000223073.2
ENST00000459726.1
RNA binding motif protein 28
chr11_+_111957497 5.65 ENST00000375549.3
ENST00000528182.1
ENST00000528048.1
ENST00000528021.1
ENST00000526592.1
ENST00000525291.1
succinate dehydrogenase complex, subunit D, integral membrane protein
chr7_-_150777949 5.59 ENST00000482571.1
Fas-activated serine/threonine kinase
chr6_-_111927062 5.57 ENST00000359831.4
TRAF3 interacting protein 2
chr11_-_111957451 5.37 ENST00000504148.2
ENST00000541231.1
translocase of inner mitochondrial membrane 8 homolog B (yeast)
chr7_-_150777874 5.29 ENST00000540185.1
Fas-activated serine/threonine kinase
chr16_-_30457048 5.20 ENST00000500504.2
ENST00000542752.1
selenophosphate synthetase 2
chr11_-_111741994 5.16 ENST00000398006.2
ALG9, alpha-1,2-mannosyltransferase
chr7_-_150777920 5.02 ENST00000353841.2
ENST00000297532.6
Fas-activated serine/threonine kinase
chr19_+_46850251 4.79 ENST00000012443.4
protein phosphatase 5, catalytic subunit
chr10_+_99185917 4.72 ENST00000334828.5
phosphoglycerate mutase 1 (brain)
chr20_-_3748416 4.34 ENST00000399672.1
chromosome 20 open reading frame 27
chr3_+_113465866 4.26 ENST00000273398.3
ENST00000538620.1
ENST00000496747.1
ENST00000475322.1
ATPase, H+ transporting, lysosomal 70kDa, V1 subunit A
chr11_+_66624527 4.21 ENST00000393952.3
leucine rich repeat and fibronectin type III domain containing 4
chr3_+_179322481 4.21 ENST00000259037.3
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 5, 16kDa
chr17_-_41132010 4.13 ENST00000409103.1
ENST00000360221.4
PTGES3L-AARSD1 readthrough
chr7_+_73868439 3.97 ENST00000424337.2
GTF2I repeat domain containing 1
chr19_+_46850320 3.89 ENST00000391919.1
protein phosphatase 5, catalytic subunit
chr18_-_12377283 3.83 ENST00000269143.3
AFG3-like AAA ATPase 2
chr16_-_1821496 3.75 ENST00000564628.1
ENST00000563498.1
NME/NM23 nucleoside diphosphate kinase 3
chr12_+_120875910 3.71 ENST00000551806.1
Glutamyl-tRNA(Gln) amidotransferase subunit C, mitochondrial
chr8_-_134072593 3.68 ENST00000427060.2
Src-like-adaptor
chr10_+_75757863 3.62 ENST00000372755.3
ENST00000211998.4
ENST00000417648.2
vinculin
chr16_-_30537839 3.30 ENST00000380412.5
zinc finger protein 768
chr12_+_56414851 3.26 ENST00000547167.1
IKAROS family zinc finger 4 (Eos)
chr1_+_212738676 3.22 ENST00000366981.4
ENST00000366987.2
activating transcription factor 3
chr5_+_169780485 3.01 ENST00000377360.4
Kv channel interacting protein 1
chr3_-_42845951 2.93 ENST00000418900.2
ENST00000430190.1
HIG1 hypoxia inducible domain family, member 1A
chr3_-_27498235 2.93 ENST00000295736.5
ENST00000428386.1
ENST00000428179.1
solute carrier family 4, sodium bicarbonate cotransporter, member 7
chr17_+_42148225 2.73 ENST00000591696.1
glucose 6 phosphatase, catalytic, 3
chr8_-_100905925 2.72 ENST00000518171.1
cytochrome c oxidase subunit VIc
chr5_-_140027357 2.58 ENST00000252102.4
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 2, 8kDa
chr6_-_97345689 2.57 ENST00000316149.7
NADH dehydrogenase (ubiquinone) complex I, assembly factor 4
chr1_+_104159999 2.56 ENST00000414303.2
ENST00000423678.1
amylase, alpha 2A (pancreatic)
chr10_+_112257596 2.51 ENST00000369583.3
dual specificity phosphatase 5
chr3_-_24536253 2.40 ENST00000428492.1
ENST00000396671.2
ENST00000431815.1
ENST00000418247.1
ENST00000416420.1
ENST00000356447.4
thyroid hormone receptor, beta
chr2_-_207024233 2.34 ENST00000423725.1
ENST00000233190.6
NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa (NADH-coenzyme Q reductase)
chr9_-_35685452 2.23 ENST00000607559.1
tropomyosin 2 (beta)
chr17_+_40996590 2.18 ENST00000253799.3
ENST00000452774.2
amine oxidase, copper containing 2 (retina-specific)
chr6_-_41703296 2.10 ENST00000373033.1
transcription factor EB
chr19_-_11689752 2.07 ENST00000592659.1
ENST00000592828.1
ENST00000218758.5
ENST00000412435.2
acid phosphatase 5, tartrate resistant
chr12_-_57039739 2.06 ENST00000552959.1
ENST00000551020.1
ENST00000553007.2
ENST00000552919.1
ENST00000552104.1
ENST00000262030.3
ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide
chr7_-_43965937 1.90 ENST00000455877.1
ENST00000223341.7
ENST00000447717.3
ENST00000426198.1
upregulator of cell proliferation
chr16_-_30538079 1.89 ENST00000562803.1
zinc finger protein 768
chr2_+_162016804 1.76 ENST00000392749.2
ENST00000440506.1
TRAF family member-associated NFKB activator
chr19_+_45251804 1.74 ENST00000164227.5
B-cell CLL/lymphoma 3
chr16_+_31366536 1.70 ENST00000562522.1
integrin, alpha X (complement component 3 receptor 4 subunit)
chr20_+_49126881 1.68 ENST00000371621.3
ENST00000541713.1
protein tyrosine phosphatase, non-receptor type 1
chr11_+_128563652 1.54 ENST00000527786.2
Fli-1 proto-oncogene, ETS transcription factor
chr9_+_139717847 1.46 ENST00000436380.1
RAB, member RAS oncogene family-like 6
chr10_-_14050522 1.45 ENST00000342409.2
FERM domain containing 4A
chr16_+_29991673 1.42 ENST00000416441.2
TAO kinase 2
chr19_+_16059818 1.35 ENST00000322107.1
olfactory receptor, family 10, subfamily H, member 4
chr10_+_104178946 1.33 ENST00000432590.1
F-box and leucine-rich repeat protein 15
chr17_+_48423453 1.30 ENST00000017003.2
ENST00000509778.1
ENST00000507602.1
xylosyltransferase II
chr1_-_185286461 1.24 ENST00000367498.3
influenza virus NS1A binding protein
chr8_-_100905850 1.18 ENST00000520271.1
ENST00000522940.1
ENST00000523016.1
ENST00000517682.2
ENST00000297564.2
cytochrome c oxidase subunit VIc
chr19_+_48898132 1.18 ENST00000263269.3
glutamate receptor, ionotropic, N-methyl D-aspartate 2D
chr19_-_49552006 1.13 ENST00000391869.3
chorionic gonadotropin, beta polypeptide 1
chr15_-_75017711 1.06 ENST00000567032.1
ENST00000564596.1
ENST00000566503.1
ENST00000395049.4
ENST00000395048.2
ENST00000379727.3
cytochrome P450, family 1, subfamily A, polypeptide 1
chr12_+_69139886 1.03 ENST00000398004.2
solute carrier family 35, member E3
chr12_+_93963590 0.95 ENST00000340600.2
suppressor of cytokine signaling 2
chrX_-_108725301 0.93 ENST00000218006.2
guanylate cyclase 2F, retinal
chr16_+_31366455 0.83 ENST00000268296.4
integrin, alpha X (complement component 3 receptor 4 subunit)
chr2_+_162016916 0.82 ENST00000405852.1
TRAF family member-associated NFKB activator
chr6_-_43021437 0.56 ENST00000265348.3
cullin 7
chr3_-_49377446 0.54 ENST00000351842.4
ENST00000416417.1
ENST00000415188.1
ubiquitin specific peptidase 4 (proto-oncogene)
chr17_-_27503770 0.53 ENST00000533112.1
myosin XVIIIA
chr5_+_32788945 0.52 ENST00000326958.1
AC026703.1
chr18_-_43678241 0.49 ENST00000593152.2
ENST00000589252.1
ENST00000590665.1
ENST00000398752.6
ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle
chr16_+_56899114 0.47 ENST00000566786.1
ENST00000438926.2
ENST00000563236.1
ENST00000262502.5
solute carrier family 12 (sodium/chloride transporter), member 3
chr15_+_78441663 0.36 ENST00000299518.2
ENST00000558554.1
ENST00000557826.1
ENST00000561279.1
ENST00000559186.1
ENST00000560770.1
ENST00000559881.1
ENST00000559205.1
ENST00000441490.2
isocitrate dehydrogenase 3 (NAD+) alpha
chr6_+_44126545 0.28 ENST00000532171.1
ENST00000398776.1
ENST00000542245.1
calpain 11
chr8_-_100905363 0.27 ENST00000524245.1
cytochrome c oxidase subunit VIc
chr17_+_4855053 0.23 ENST00000518175.1
enolase 3 (beta, muscle)
chr1_+_104293028 0.23 ENST00000370079.3
amylase, alpha 1C (salivary)
chr1_+_206858232 0.21 ENST00000294981.4
mitogen-activated protein kinase-activated protein kinase 2
chr11_+_64879317 0.18 ENST00000526809.1
ENST00000279263.7
ENST00000524986.1
ENST00000534371.1
ENST00000540748.1
ENST00000525385.1
ENST00000345348.5
ENST00000531321.1
ENST00000529414.1
ENST00000526085.1
ENST00000530750.1
transmembrane 7 superfamily member 2
chr11_-_67271723 0.16 ENST00000533391.1
ENST00000534749.1
ENST00000532703.1
phosphatidylinositol transfer protein, membrane-associated 1
chr2_+_134877740 0.07 ENST00000409645.1
mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase

Network of associatons between targets according to the STRING database.

First level regulatory network of RORA

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
7.0 20.9 GO:0007518 myoblast fate determination(GO:0007518)
6.1 42.4 GO:1904044 response to aldosterone(GO:1904044)
6.0 18.1 GO:0006172 ADP biosynthetic process(GO:0006172)
6.0 60.0 GO:0007144 female meiosis I(GO:0007144)
4.9 19.4 GO:0090296 regulation of mitochondrial DNA replication(GO:0090296)
4.8 14.4 GO:2000276 regulation of mitochondrial membrane permeability involved in programmed necrotic cell death(GO:1902445) negative regulation of oxidative phosphorylation uncoupler activity(GO:2000276)
4.5 31.5 GO:0070934 CRD-mediated mRNA stabilization(GO:0070934)
3.5 13.9 GO:0043335 protein unfolding(GO:0043335)
3.3 10.0 GO:0006097 glyoxylate cycle(GO:0006097)
2.9 11.4 GO:0006627 protein processing involved in protein targeting to mitochondrion(GO:0006627)
2.6 12.8 GO:0061088 regulation of sequestering of zinc ion(GO:0061088)
2.5 22.3 GO:0045039 protein import into mitochondrial inner membrane(GO:0045039)
2.2 8.7 GO:0019046 release from viral latency(GO:0019046)
1.9 5.7 GO:0006121 mitochondrial electron transport, succinate to ubiquinone(GO:0006121)
1.8 7.3 GO:0021812 neuronal-glial interaction involved in cerebral cortex radial glia guided migration(GO:0021812)
1.8 21.3 GO:0046051 UTP biosynthetic process(GO:0006228) UTP metabolic process(GO:0046051)
1.7 5.2 GO:0016260 selenocysteine biosynthetic process(GO:0016260)
1.7 11.7 GO:0034316 negative regulation of Arp2/3 complex-mediated actin nucleation(GO:0034316)
1.6 13.1 GO:0070601 centromeric sister chromatid cohesion(GO:0070601)
1.4 19.5 GO:0051599 response to hydrostatic pressure(GO:0051599)
1.2 4.7 GO:0043456 regulation of pentose-phosphate shunt(GO:0043456)
1.1 3.2 GO:0061394 regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance(GO:0061394)
1.1 16.0 GO:0090344 negative regulation of cell aging(GO:0090344)
1.1 22.1 GO:0033169 histone H3-K9 demethylation(GO:0033169)
1.0 8.3 GO:0044351 macropinocytosis(GO:0044351)
1.0 17.3 GO:0006044 N-acetylglucosamine metabolic process(GO:0006044)
1.0 3.8 GO:0034982 mitochondrial protein processing(GO:0034982)
0.9 11.6 GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c(GO:0006122)
0.8 2.4 GO:0008050 female courtship behavior(GO:0008050)
0.8 4.0 GO:0014886 transition between slow and fast fiber(GO:0014886)
0.6 24.5 GO:0042407 cristae formation(GO:0042407)
0.6 39.7 GO:0006120 mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
0.6 1.7 GO:0045082 positive regulation of interleukin-10 biosynthetic process(GO:0045082)
0.6 8.7 GO:0016576 histone dephosphorylation(GO:0016576)
0.5 10.8 GO:0051085 chaperone mediated protein folding requiring cofactor(GO:0051085)
0.5 5.4 GO:0072321 chaperone-mediated protein transport(GO:0072321)
0.5 11.4 GO:0097242 beta-amyloid clearance(GO:0097242)
0.4 6.2 GO:0001553 luteinization(GO:0001553)
0.4 2.1 GO:0032929 negative regulation of superoxide anion generation(GO:0032929)
0.4 20.2 GO:0043486 histone exchange(GO:0043486)
0.4 2.7 GO:0015760 hexose phosphate transport(GO:0015712) glucose-6-phosphate transport(GO:0015760)
0.4 2.6 GO:0044245 polysaccharide digestion(GO:0044245)
0.4 1.1 GO:0018894 dibenzo-p-dioxin metabolic process(GO:0018894) cellular alkene metabolic process(GO:0043449)
0.3 5.2 GO:0006488 dolichol-linked oligosaccharide biosynthetic process(GO:0006488)
0.3 1.7 GO:0030948 negative regulation of vascular endothelial growth factor receptor signaling pathway(GO:0030948) regulation of receptor catabolic process(GO:2000644)
0.2 5.6 GO:0002230 positive regulation of defense response to virus by host(GO:0002230)
0.2 11.8 GO:0006656 phosphatidylcholine biosynthetic process(GO:0006656)
0.2 10.1 GO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0000083)
0.2 3.6 GO:0090136 epithelial cell-cell adhesion(GO:0090136)
0.2 4.3 GO:0036295 cellular response to increased oxygen levels(GO:0036295)
0.2 9.5 GO:0006409 tRNA export from nucleus(GO:0006409) tRNA-containing ribonucleoprotein complex export from nucleus(GO:0071431)
0.2 7.2 GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000462)
0.2 2.5 GO:0035970 peptidyl-threonine dephosphorylation(GO:0035970)
0.2 0.5 GO:1903028 positive regulation of opsonization(GO:1903028)
0.2 8.7 GO:0099601 regulation of neurotransmitter receptor activity(GO:0099601) regulation of glutamate receptor signaling pathway(GO:1900449)
0.2 6.7 GO:0051894 positive regulation of focal adhesion assembly(GO:0051894)
0.1 2.9 GO:0060117 auditory receptor cell development(GO:0060117)
0.1 2.6 GO:0097031 NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031)
0.1 6.6 GO:0043276 anoikis(GO:0043276) nucleotide-binding oligomerization domain containing signaling pathway(GO:0070423)
0.1 2.9 GO:0061418 regulation of transcription from RNA polymerase II promoter in response to hypoxia(GO:0061418)
0.1 3.0 GO:1901379 regulation of potassium ion transport(GO:0043266) regulation of potassium ion transmembrane transport(GO:1901379)
0.1 7.2 GO:0050909 sensory perception of taste(GO:0050909)
0.1 1.3 GO:0030210 heparin metabolic process(GO:0030202) heparin biosynthetic process(GO:0030210)
0.1 1.7 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
0.1 18.6 GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling(GO:0043123)
0.1 0.9 GO:0007168 receptor guanylyl cyclase signaling pathway(GO:0007168)
0.1 1.5 GO:0035855 megakaryocyte development(GO:0035855)
0.1 6.8 GO:0045333 cellular respiration(GO:0045333)
0.1 10.3 GO:0043484 regulation of RNA splicing(GO:0043484)
0.1 1.5 GO:0090162 establishment of epithelial cell polarity(GO:0090162)
0.1 13.5 GO:0006457 protein folding(GO:0006457)
0.1 5.4 GO:0035335 peptidyl-tyrosine dephosphorylation(GO:0035335)
0.1 7.0 GO:0006414 translational elongation(GO:0006414)
0.0 0.5 GO:0000244 spliceosomal tri-snRNP complex assembly(GO:0000244)
0.0 3.7 GO:0038083 peptidyl-tyrosine autophosphorylation(GO:0038083)
0.0 1.1 GO:0030728 ovulation(GO:0030728)
0.0 2.1 GO:0007040 lysosome organization(GO:0007040) lytic vacuole organization(GO:0080171)
0.0 13.6 GO:0042278 purine nucleoside metabolic process(GO:0042278)
0.0 2.5 GO:0034113 heterotypic cell-cell adhesion(GO:0034113)
0.0 10.7 GO:0000209 protein polyubiquitination(GO:0000209)
0.0 1.4 GO:0031572 G2 DNA damage checkpoint(GO:0031572)
0.0 3.3 GO:0051291 protein heterooligomerization(GO:0051291)
0.0 1.2 GO:0001964 startle response(GO:0001964)
0.0 1.4 GO:0050911 detection of chemical stimulus involved in sensory perception of smell(GO:0050911)
0.0 1.2 GO:0006383 transcription from RNA polymerase III promoter(GO:0006383)
0.0 2.1 GO:0006805 xenobiotic metabolic process(GO:0006805)
0.0 4.6 GO:0043687 post-translational protein modification(GO:0043687)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
5.6 22.3 GO:0042721 mitochondrial inner membrane protein insertion complex(GO:0042721)
3.9 31.5 GO:0071204 histone pre-mRNA 3'end processing complex(GO:0071204)
3.2 9.5 GO:1990876 cytoplasmic side of nuclear pore(GO:1990876)
2.4 7.3 GO:0005607 laminin-2 complex(GO:0005607)
2.3 11.4 GO:0034688 integrin alphaM-beta2 complex(GO:0034688)
2.2 11.0 GO:0045272 plasma membrane respiratory chain complex I(GO:0045272)
1.9 13.1 GO:0031415 NatA complex(GO:0031415)
1.6 27.1 GO:0043020 NADPH oxidase complex(GO:0043020)
1.6 11.0 GO:0061617 MICOS complex(GO:0061617)
1.6 17.3 GO:0033018 sarcoplasmic reticulum lumen(GO:0033018)
1.4 5.7 GO:0045283 mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)(GO:0005749) succinate dehydrogenase complex (ubiquinone)(GO:0045257) respiratory chain complex II(GO:0045273) succinate dehydrogenase complex(GO:0045281) fumarate reductase complex(GO:0045283)
1.2 8.7 GO:1990635 proximal dendrite(GO:1990635)
1.1 3.2 GO:1990622 CHOP-ATF3 complex(GO:1990622)
1.1 5.4 GO:0042719 mitochondrial intermembrane space protein transporter complex(GO:0042719)
1.0 11.4 GO:0045275 mitochondrial respiratory chain complex III(GO:0005750) respiratory chain complex III(GO:0045275)
1.0 20.2 GO:0000812 Swr1 complex(GO:0000812)
0.9 27.9 GO:0005753 mitochondrial proton-transporting ATP synthase complex(GO:0005753)
0.8 64.5 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.7 7.2 GO:0005853 eukaryotic translation elongation factor 1 complex(GO:0005853)
0.6 19.5 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.5 28.7 GO:0005747 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.5 6.6 GO:0008385 IkappaB kinase complex(GO:0008385)
0.4 1.7 GO:0033257 Bcl3/NF-kappaB2 complex(GO:0033257)
0.4 9.4 GO:0071682 endocytic vesicle lumen(GO:0071682)
0.3 3.6 GO:0005916 fascia adherens(GO:0005916)
0.3 4.3 GO:0033180 proton-transporting V-type ATPase, V1 domain(GO:0033180)
0.3 58.0 GO:0000922 spindle pole(GO:0000922)
0.3 7.2 GO:0034706 sodium channel complex(GO:0034706)
0.2 1.7 GO:0098554 cytoplasmic side of endoplasmic reticulum membrane(GO:0098554)
0.2 44.0 GO:0101002 ficolin-1-rich granule(GO:0101002) ficolin-1-rich granule lumen(GO:1904813)
0.2 3.8 GO:0031305 intrinsic component of mitochondrial inner membrane(GO:0031304) integral component of mitochondrial inner membrane(GO:0031305)
0.2 5.2 GO:0005665 DNA-directed RNA polymerase II, core complex(GO:0005665)
0.2 12.3 GO:0030315 T-tubule(GO:0030315)
0.1 0.6 GO:1990393 3M complex(GO:1990393)
0.1 2.0 GO:0005862 muscle thin filament tropomyosin(GO:0005862)
0.1 7.2 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.1 2.9 GO:0032420 stereocilium(GO:0032420)
0.1 2.5 GO:0008305 integrin complex(GO:0008305)
0.1 27.0 GO:0005759 mitochondrial matrix(GO:0005759)
0.1 10.1 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
0.0 0.2 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
0.0 0.9 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.0 6.3 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.0 1.3 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.0 11.9 GO:0000785 chromatin(GO:0000785)
0.0 0.5 GO:0070469 respiratory chain(GO:0070469)
0.0 3.6 GO:0005681 spliceosomal complex(GO:0005681)
0.0 6.4 GO:0005911 cell-cell junction(GO:0005911)
0.0 19.1 GO:0005615 extracellular space(GO:0005615)
0.0 4.8 GO:0005813 centrosome(GO:0005813)
0.0 3.6 GO:0005769 early endosome(GO:0005769)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
5.3 15.9 GO:0033867 Fas-activated serine/threonine kinase activity(GO:0033867)
3.9 11.6 GO:0045155 electron transporter, transferring electrons from CoQH2-cytochrome c reductase complex and cytochrome c oxidase complex activity(GO:0045155)
3.3 10.0 GO:0004450 isocitrate dehydrogenase (NADP+) activity(GO:0004450)
2.5 17.6 GO:0004673 protein histidine kinase activity(GO:0004673)
2.4 11.8 GO:0052740 1-acyl-2-lysophosphatidylserine acylhydrolase activity(GO:0052740)
2.3 9.2 GO:0004727 prenylated protein tyrosine phosphatase activity(GO:0004727)
2.2 17.3 GO:0004563 beta-N-acetylhexosaminidase activity(GO:0004563)
2.2 19.4 GO:1901612 cardiolipin binding(GO:1901612)
1.9 5.7 GO:0008177 succinate dehydrogenase (ubiquinone) activity(GO:0008177)
1.7 5.2 GO:0016781 selenide, water dikinase activity(GO:0004756) phosphotransferase activity, paired acceptors(GO:0016781)
1.7 5.2 GO:0000026 alpha-1,2-mannosyltransferase activity(GO:0000026)
1.6 11.4 GO:0030369 ICAM-3 receptor activity(GO:0030369)
1.5 18.1 GO:0004017 adenylate kinase activity(GO:0004017)
1.5 11.7 GO:0071933 Arp2/3 complex binding(GO:0071933)
1.4 13.9 GO:0030911 TPR domain binding(GO:0030911)
1.4 27.1 GO:0016175 superoxide-generating NADPH oxidase activity(GO:0016175)
1.2 4.7 GO:0004082 bisphosphoglycerate mutase activity(GO:0004082) phosphoglycerate mutase activity(GO:0004619) 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity(GO:0046538)
1.2 22.1 GO:0032454 histone demethylase activity (H3-K9 specific)(GO:0032454)
1.0 14.4 GO:0016018 cyclosporin A binding(GO:0016018)
1.0 13.1 GO:0004596 peptide alpha-N-acetyltransferase activity(GO:0004596)
0.9 18.6 GO:0050786 RAGE receptor binding(GO:0050786)
0.9 7.9 GO:0016174 NAD(P)H oxidase activity(GO:0016174)
0.9 9.5 GO:0005049 nuclear export signal receptor activity(GO:0005049)
0.7 39.7 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.7 2.2 GO:0052596 tryptamine:oxygen oxidoreductase (deaminating) activity(GO:0052593) aminoacetone:oxygen oxidoreductase(deaminating) activity(GO:0052594) aliphatic-amine oxidase activity(GO:0052595) phenethylamine:oxygen oxidoreductase (deaminating) activity(GO:0052596)
0.7 2.7 GO:0050309 glucose-6-phosphatase activity(GO:0004346) sugar-terminal-phosphatase activity(GO:0050309)
0.7 12.8 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.6 2.6 GO:0016160 amylase activity(GO:0016160)
0.5 7.2 GO:0015280 ligand-gated sodium channel activity(GO:0015280)
0.5 13.5 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.5 6.6 GO:0042975 peroxisome proliferator activated receptor binding(GO:0042975)
0.5 60.3 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
0.5 3.7 GO:0004550 nucleoside diphosphate kinase activity(GO:0004550)
0.4 8.3 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)
0.4 1.3 GO:0030158 protein xylosyltransferase activity(GO:0030158)
0.3 3.6 GO:0045294 alpha-catenin binding(GO:0045294)
0.3 40.1 GO:0003697 single-stranded DNA binding(GO:0003697)
0.3 8.7 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.3 6.2 GO:0016832 aldehyde-lyase activity(GO:0016832)
0.3 7.2 GO:0003746 translation elongation factor activity(GO:0003746)
0.3 19.5 GO:0019213 deacetylase activity(GO:0019213)
0.2 2.4 GO:0070324 thyroid hormone binding(GO:0070324)
0.2 19.0 GO:0097110 scaffold protein binding(GO:0097110)
0.2 1.1 GO:0070576 vitamin D 24-hydroxylase activity(GO:0070576)
0.2 11.1 GO:0019212 phosphatase inhibitor activity(GO:0019212)
0.2 4.3 GO:0044769 ATPase activity, coupled to transmembrane movement of ions, rotational mechanism(GO:0044769) proton-transporting ATPase activity, rotational mechanism(GO:0046961)
0.2 9.2 GO:0035255 ionotropic glutamate receptor binding(GO:0035255)
0.2 22.3 GO:0008565 protein transporter activity(GO:0008565)
0.2 0.5 GO:0031685 adenosine receptor binding(GO:0031685)
0.2 2.1 GO:0003993 acid phosphatase activity(GO:0003993)
0.2 2.9 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
0.1 15.2 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.1 1.2 GO:0004972 NMDA glutamate receptor activity(GO:0004972)
0.1 0.4 GO:0004449 isocitrate dehydrogenase (NAD+) activity(GO:0004449)
0.1 1.4 GO:0004993 G-protein coupled serotonin receptor activity(GO:0004993)
0.1 10.8 GO:0051082 unfolded protein binding(GO:0051082)
0.1 6.7 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.1 1.4 GO:0031434 mitogen-activated protein kinase kinase binding(GO:0031434)
0.1 0.2 GO:0050613 delta14-sterol reductase activity(GO:0050613)
0.1 1.7 GO:0015002 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.1 3.3 GO:0043425 bHLH transcription factor binding(GO:0043425)
0.1 13.1 GO:0061630 ubiquitin protein ligase activity(GO:0061630)
0.1 0.9 GO:0019992 diacylglycerol binding(GO:0019992)
0.0 3.0 GO:0015459 potassium channel regulator activity(GO:0015459)
0.0 3.7 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.0 32.9 GO:0008270 zinc ion binding(GO:0008270)
0.0 1.5 GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding(GO:0000980)
0.0 0.2 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
0.0 0.9 GO:0004383 guanylate cyclase activity(GO:0004383)
0.0 2.1 GO:0046983 protein dimerization activity(GO:0046983)
0.0 0.5 GO:0015377 cation:chloride symporter activity(GO:0015377)
0.0 7.2 GO:0003735 structural constituent of ribosome(GO:0003735)
0.0 4.0 GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
0.0 0.2 GO:0008526 phosphatidylinositol transporter activity(GO:0008526)
0.0 0.5 GO:0043531 ADP binding(GO:0043531)
0.0 5.4 GO:0046982 protein heterodimerization activity(GO:0046982)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
4.3 60.0 SA G2 AND M PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.6 17.6 PID ARF6 DOWNSTREAM PATHWAY Arf6 downstream pathway
0.5 7.3 PID INTEGRIN4 PATHWAY Alpha6 beta4 integrin-ligand interactions
0.4 13.9 PID ERBB NETWORK PATHWAY ErbB receptor signaling network
0.4 9.2 PID PRL SIGNALING EVENTS PATHWAY Signaling events mediated by PRL
0.4 27.7 PID P38 ALPHA BETA DOWNSTREAM PATHWAY Signaling mediated by p38-alpha and p38-beta
0.4 27.1 PID RAC1 PATHWAY RAC1 signaling pathway
0.4 26.9 PID CERAMIDE PATHWAY Ceramide signaling pathway
0.3 33.1 PID PTP1B PATHWAY Signaling events mediated by PTP1B
0.3 14.0 PID INTEGRIN CS PATHWAY Integrin family cell surface interactions
0.3 9.5 PID SMAD2 3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.2 6.2 PID S1P META PATHWAY Sphingosine 1-phosphate (S1P) pathway
0.2 6.6 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling
0.2 1.7 PID NFKAPPAB ATYPICAL PATHWAY Atypical NF-kappaB pathway
0.1 3.6 PID RHOA PATHWAY RhoA signaling pathway
0.1 5.7 PID ATF2 PATHWAY ATF-2 transcription factor network
0.1 6.7 PID ILK PATHWAY Integrin-linked kinase signaling
0.1 10.1 PID E2F PATHWAY E2F transcription factor network
0.1 8.7 PID REG GR PATHWAY Glucocorticoid receptor regulatory network
0.1 2.4 PID RXR VDR PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.1 1.4 PID P38 MKK3 6PATHWAY p38 MAPK signaling pathway
0.0 14.7 NABA SECRETED FACTORS Genes encoding secreted soluble factors
0.0 0.9 PID CONE PATHWAY Visual signal transduction: Cones
0.0 0.9 PID RAS PATHWAY Regulation of Ras family activation
0.0 3.0 PID PDGFRB PATHWAY PDGFR-beta signaling pathway

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
2.2 60.0 REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION Genes involved in Cyclin A/B1 associated events during G2/M transition
1.1 35.7 REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.8 70.1 REACTOME RESPIRATORY ELECTRON TRANSPORT Genes involved in Respiratory electron transport
0.8 12.8 REACTOME ZINC TRANSPORTERS Genes involved in Zinc transporters
0.7 31.3 REACTOME LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis
0.7 13.9 REACTOME TETRAHYDROBIOPTERIN BH4 SYNTHESIS RECYCLING SALVAGE AND REGULATION Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
0.6 13.5 REACTOME FORMATION OF ATP BY CHEMIOSMOTIC COUPLING Genes involved in Formation of ATP by chemiosmotic coupling
0.6 6.6 REACTOME IRAK1 RECRUITS IKK COMPLEX Genes involved in IRAK1 recruits IKK complex
0.5 8.3 REACTOME DESTABILIZATION OF MRNA BY BRF1 Genes involved in Destabilization of mRNA by Butyrate Response Factor 1 (BRF1)
0.5 27.7 REACTOME MITOCHONDRIAL PROTEIN IMPORT Genes involved in Mitochondrial Protein Import
0.3 2.8 REACTOME DIGESTION OF DIETARY CARBOHYDRATE Genes involved in Digestion of dietary carbohydrate
0.3 9.5 REACTOME NEP NS2 INTERACTS WITH THE CELLULAR EXPORT MACHINERY Genes involved in NEP/NS2 Interacts with the Cellular Export Machinery
0.2 6.7 REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.2 10.4 REACTOME PYRUVATE METABOLISM AND CITRIC ACID TCA CYCLE Genes involved in Pyruvate metabolism and Citric Acid (TCA) cycle
0.2 5.2 REACTOME BIOSYNTHESIS OF THE N GLYCAN PRECURSOR DOLICHOL LIPID LINKED OLIGOSACCHARIDE LLO AND TRANSFER TO A NASCENT PROTEIN Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
0.2 28.7 REACTOME MRNA SPLICING Genes involved in mRNA Splicing
0.2 23.9 REACTOME INTEGRIN CELL SURFACE INTERACTIONS Genes involved in Integrin cell surface interactions
0.2 2.7 REACTOME GLUCOSE TRANSPORT Genes involved in Glucose transport
0.1 3.2 REACTOME ACTIVATION OF GENES BY ATF4 Genes involved in Activation of Genes by ATF4
0.1 5.0 REACTOME GLYCOLYSIS Genes involved in Glycolysis
0.1 18.8 REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.1 14.4 REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 Genes involved in Response to elevated platelet cytosolic Ca2+
0.1 7.2 REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.1 1.2 REACTOME RAS ACTIVATION UOPN CA2 INFUX THROUGH NMDA RECEPTOR Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor
0.1 1.1 REACTOME XENOBIOTICS Genes involved in Xenobiotics
0.0 13.6 REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.0 7.2 REACTOME TRANSLATION Genes involved in Translation
0.0 2.1 REACTOME METABOLISM OF VITAMINS AND COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.0 1.4 REACTOME OLFACTORY SIGNALING PATHWAY Genes involved in Olfactory Signaling Pathway
0.0 2.9 REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.0 0.5 REACTOME SIGNALING BY FGFR1 FUSION MUTANTS Genes involved in Signaling by FGFR1 fusion mutants