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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for BACH1_NFE2_NFE2L2

Z-value: 2.07

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Transcription factors associated with BACH1_NFE2_NFE2L2

Gene Symbol Gene ID Gene Info
ENSG00000156273.11 BTB domain and CNC homolog 1
ENSG00000123405.9 nuclear factor, erythroid 2
ENSG00000116044.11 nuclear factor, erythroid 2 like 2

Activity profile of BACH1_NFE2_NFE2L2 motif

Sorted Z-values of BACH1_NFE2_NFE2L2 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr14_+_58711539 119.09 ENST00000216455.4
ENST00000412908.2
ENST00000557508.1
proteasome (prosome, macropain) subunit, alpha type, 3
chr9_-_113018835 88.19 ENST00000374517.5
thioredoxin
chr16_-_69760409 78.18 ENST00000561500.1
ENST00000439109.2
ENST00000564043.1
ENST00000379046.2
ENST00000379047.3
NAD(P)H dehydrogenase, quinone 1
chr17_-_73150629 72.97 ENST00000356033.4
ENST00000405458.3
ENST00000409753.3
hematological and neurological expressed 1
chr1_-_45987526 67.45 ENST00000372079.1
ENST00000262746.1
ENST00000447184.1
ENST00000319248.8
peroxiredoxin 1
chr16_+_89988259 63.39 ENST00000554444.1
ENST00000556565.1
Tubulin beta-3 chain
chr9_-_113018746 62.94 ENST00000374515.5
thioredoxin
chr1_-_109968973 53.77 ENST00000271308.4
ENST00000538610.1
proteasome (prosome, macropain) subunit, alpha type, 5
chr12_+_104680659 49.52 ENST00000526691.1
ENST00000531691.1
ENST00000388854.3
ENST00000354940.6
ENST00000526390.1
ENST00000531689.1
thioredoxin reductase 1
chrX_-_15511438 49.42 ENST00000380420.5
pirin (iron-binding nuclear protein)
chr16_+_30077055 48.88 ENST00000564595.2
ENST00000569798.1
aldolase A, fructose-bisphosphate
chr18_+_158513 47.71 ENST00000400266.3
ENST00000580410.1
ENST00000383589.2
ENST00000261601.7
ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase)
chr1_-_225616515 46.80 ENST00000338179.2
ENST00000425080.1
lamin B receptor
chr7_+_112063192 46.41 ENST00000005558.4
interferon-related developmental regulator 1
chr10_-_127505167 44.36 ENST00000368786.1
uroporphyrinogen III synthase
chr1_-_94374946 43.71 ENST00000370238.3
glutamate-cysteine ligase, modifier subunit
chr16_+_74330673 40.40 ENST00000219313.4
ENST00000540379.1
ENST00000567958.1
ENST00000568615.2
proteasome (prosome, macropain) 26S subunit, non-ATPase, 7
chr11_-_14541872 39.82 ENST00000419365.2
ENST00000530457.1
ENST00000532256.1
ENST00000533068.1
proteasome (prosome, macropain) subunit, alpha type, 1
chr14_+_35761580 38.58 ENST00000553809.1
ENST00000555764.1
ENST00000556506.1
proteasome (prosome, macropain) subunit, alpha type, 6
chr10_+_85899196 37.76 ENST00000372134.3
growth hormone inducible transmembrane protein
chr6_+_44214824 37.66 ENST00000371646.5
ENST00000353801.3
heat shock protein 90kDa alpha (cytosolic), class B member 1
chrX_+_153770421 37.51 ENST00000369609.5
ENST00000369607.1
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma
chr6_-_3157760 36.90 ENST00000333628.3
tubulin, beta 2A class IIa
chr21_+_33031935 34.19 ENST00000270142.6
ENST00000389995.4
superoxide dismutase 1, soluble
chr14_+_35761540 34.18 ENST00000261479.4
proteasome (prosome, macropain) subunit, alpha type, 6
chr16_+_30077098 32.02 ENST00000395240.3
ENST00000566846.1
aldolase A, fructose-bisphosphate
chr1_+_165796753 31.59 ENST00000367879.4
uridine-cytidine kinase 2
chr11_+_67351019 30.96 ENST00000398606.3
glutathione S-transferase pi 1
chr5_-_137911049 30.59 ENST00000297185.3
heat shock 70kDa protein 9 (mortalin)
chr17_+_30771279 30.47 ENST00000261712.3
ENST00000578213.1
ENST00000457654.2
ENST00000579451.1
proteasome (prosome, macropain) 26S subunit, non-ATPase, 11
chr10_+_106013923 29.58 ENST00000539281.1
glutathione S-transferase omega 1
chr6_-_84140757 29.19 ENST00000541327.1
ENST00000369705.3
ENST00000543031.1
malic enzyme 1, NADP(+)-dependent, cytosolic
chr6_-_35888905 28.01 ENST00000510290.1
ENST00000423325.2
ENST00000373822.1
SRSF protein kinase 1
chr8_-_30585439 27.08 ENST00000221130.5
glutathione reductase
chr22_-_19466683 26.14 ENST00000399523.1
ENST00000421968.2
ENST00000447868.1
ubiquitin fusion degradation 1 like (yeast)
chr3_+_100053625 26.12 ENST00000497785.1
nitrilase family, member 2
chr8_-_30585294 24.86 ENST00000546342.1
ENST00000541648.1
ENST00000537535.1
glutathione reductase
chr18_-_54305658 24.83 ENST00000586262.1
ENST00000217515.6
thioredoxin-like 1
chr2_+_231921574 23.99 ENST00000308696.6
ENST00000373635.4
ENST00000440838.1
ENST00000409643.1
proteasome (prosome, macropain) 26S subunit, non-ATPase, 1
chr22_-_19466732 23.86 ENST00000263202.10
ENST00000360834.4
ubiquitin fusion degradation 1 like (yeast)
chr14_+_103801140 23.52 ENST00000561325.1
ENST00000392715.2
ENST00000559130.1
ENST00000559532.1
ENST00000558506.1
eukaryotic translation initiation factor 5
chr15_+_78833071 22.87 ENST00000559365.1
proteasome (prosome, macropain) subunit, alpha type, 4
chr3_+_184038073 22.77 ENST00000428387.1
ENST00000434061.2
eukaryotic translation initiation factor 4 gamma, 1
chr10_+_106014468 22.72 ENST00000369710.4
ENST00000369713.5
ENST00000445155.1
glutathione S-transferase omega 1
chr3_+_100053542 22.53 ENST00000394140.4
nitrilase family, member 2
chr16_-_28222797 22.00 ENST00000569951.1
ENST00000565698.1
exportin 6
chr11_+_118958689 21.33 ENST00000535253.1
ENST00000392841.1
hydroxymethylbilane synthase
chr15_+_78833105 20.69 ENST00000558341.1
ENST00000559437.1
proteasome (prosome, macropain) subunit, alpha type, 4
chr15_+_78832747 20.59 ENST00000560217.1
ENST00000044462.7
ENST00000559082.1
ENST00000559948.1
ENST00000413382.2
ENST00000559146.1
ENST00000558281.1
proteasome (prosome, macropain) subunit, alpha type, 4
chr6_+_37012607 19.91 ENST00000423336.1
cytochrome c oxidase subunit VIa polypeptide 1 pseudogene 2
chr1_-_150208498 19.17 ENST00000314136.8
acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
chr10_-_75173785 19.04 ENST00000535178.1
ENST00000372921.5
ENST00000372919.4
annexin A7
chr22_+_45072958 18.93 ENST00000403581.1
proline rich 5 (renal)
chr14_-_23504087 18.92 ENST00000493471.2
ENST00000460922.2
proteasome (prosome, macropain) subunit, beta type, 5
chr22_+_45072925 18.85 ENST00000006251.7
proline rich 5 (renal)
chr20_+_60878005 18.32 ENST00000253003.2
adhesion regulating molecule 1
chr1_-_150208412 18.13 ENST00000532744.1
ENST00000369114.5
ENST00000369115.2
ENST00000369116.4
acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
chr12_-_57081940 18.08 ENST00000436399.2
prostaglandin E synthase 3 (cytosolic)
chr11_-_47447767 17.77 ENST00000530651.1
ENST00000524447.2
ENST00000531051.2
ENST00000526993.1
ENST00000602866.1
proteasome (prosome, macropain) 26S subunit, ATPase, 3
chr17_-_65362678 17.55 ENST00000357146.4
ENST00000356126.3
proteasome (prosome, macropain) 26S subunit, non-ATPase, 12
chr17_+_61905058 17.29 ENST00000375812.4
ENST00000581882.1
proteasome (prosome, macropain) 26S subunit, ATPase, 5
chr2_-_10588630 17.15 ENST00000234111.4
ornithine decarboxylase 1
chr1_+_76251879 17.13 ENST00000535300.1
ENST00000319942.3
Rab geranylgeranyltransferase, beta subunit
chr8_-_30585217 16.99 ENST00000520888.1
ENST00000414019.1
glutathione reductase
chr17_+_18625336 16.44 ENST00000395671.4
ENST00000571542.1
ENST00000395672.2
ENST00000414850.2
ENST00000424146.2
tripartite motif containing 16-like
chr1_-_150208363 16.43 ENST00000436748.2
acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
chr6_-_31704282 16.40 ENST00000375784.3
ENST00000375779.2
chloride intracellular channel 1
chrX_+_56590002 16.03 ENST00000338222.5
ubiquilin 2
chr19_+_18699535 15.62 ENST00000358607.6
chromosome 19 open reading frame 60
chr7_+_102988082 15.60 ENST00000292644.3
ENST00000544811.1
proteasome (prosome, macropain) 26S subunit, ATPase, 2
chr1_+_26605618 15.49 ENST00000270792.5
SH3 domain binding glutamic acid-rich protein like 3
chrX_-_109683446 15.47 ENST00000372057.1
Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1
chr11_-_47447970 15.23 ENST00000298852.3
ENST00000530912.1
proteasome (prosome, macropain) 26S subunit, ATPase, 3
chr7_-_42971759 15.10 ENST00000538645.1
ENST00000445517.1
ENST00000223321.4
proteasome (prosome, macropain) subunit, alpha type, 2
chr5_+_68530668 14.77 ENST00000506563.1
cyclin-dependent kinase 7
chr22_+_19466980 14.70 ENST00000407835.1
ENST00000438587.1
cell division cycle 45
chr19_-_10613421 14.45 ENST00000393623.2
kelch-like ECH-associated protein 1
chr3_+_184037466 14.45 ENST00000441154.1
eukaryotic translation initiation factor 4 gamma, 1
chr11_-_2924720 14.34 ENST00000455942.2
solute carrier family 22 (organic cation transporter), member 18 antisense
chr2_-_209118974 14.20 ENST00000415913.1
ENST00000415282.1
ENST00000446179.1
isocitrate dehydrogenase 1 (NADP+), soluble
chr17_+_61904766 14.02 ENST00000581842.1
ENST00000582130.1
ENST00000584320.1
ENST00000585123.1
ENST00000580864.1
proteasome (prosome, macropain) 26S subunit, ATPase, 5
chr18_-_55253989 13.63 ENST00000262093.5
ferrochelatase
chr11_-_62474803 13.48 ENST00000533982.1
ENST00000360796.5
Berardinelli-Seip congenital lipodystrophy 2 (seipin)
chr11_+_67351213 13.38 ENST00000398603.1
glutathione S-transferase pi 1
chr17_-_79881408 13.31 ENST00000392366.3
v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog G
chr5_+_179247759 12.92 ENST00000389805.4
ENST00000504627.1
ENST00000402874.3
ENST00000510187.1
sequestosome 1
chr7_+_134212312 12.86 ENST00000359579.4
aldo-keto reductase family 1, member B10 (aldose reductase)
chr1_+_156756667 12.56 ENST00000526188.1
ENST00000454659.1
papillary renal cell carcinoma (translocation-associated)
chr6_-_35888824 12.44 ENST00000361690.3
ENST00000512445.1
SRSF protein kinase 1
chr1_+_26869597 12.35 ENST00000530003.1
ribosomal protein S6 kinase, 90kDa, polypeptide 1
chr12_-_53343602 12.28 ENST00000546897.1
ENST00000552551.1
keratin 8
chr1_-_150208291 12.18 ENST00000533654.1
acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
chr4_+_17616253 12.14 ENST00000237380.7
mediator complex subunit 28
chr6_+_44215603 11.91 ENST00000371554.1
heat shock protein 90kDa alpha (cytosolic), class B member 1
chr17_+_30677136 11.67 ENST00000394670.4
ENST00000321233.6
ENST00000394673.2
ENST00000341711.6
ENST00000579634.1
ENST00000580759.1
ENST00000342555.6
ENST00000577908.1
ENST00000394679.5
ENST00000582165.1
zinc finger protein 207
chr3_+_120315160 11.56 ENST00000485064.1
ENST00000492739.1
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 4, 15kDa
chr3_+_120315149 11.32 ENST00000184266.2
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 4, 15kDa
chr2_-_220119280 11.23 ENST00000392088.2
tubulin, alpha 4a
chr19_+_38865398 11.15 ENST00000585598.1
ENST00000602911.1
ENST00000592561.1
proteasome (prosome, macropain) 26S subunit, non-ATPase, 8
chr5_+_68530697 10.97 ENST00000256443.3
ENST00000514676.1
cyclin-dependent kinase 7
chr17_-_61905005 10.86 ENST00000584574.1
ENST00000585145.1
ENST00000427159.2
FtsJ homolog 3 (E. coli)
chr12_-_57082060 10.68 ENST00000448157.2
ENST00000414274.3
ENST00000262033.6
ENST00000456859.2
prostaglandin E synthase 3 (cytosolic)
chr18_+_3252265 10.47 ENST00000580887.1
ENST00000536605.1
myosin, light chain 12A, regulatory, non-sarcomeric
chr19_-_59023348 10.22 ENST00000601355.1
ENST00000263093.2
solute carrier family 27 (fatty acid transporter), member 5
chr19_+_38865176 10.00 ENST00000215071.4
proteasome (prosome, macropain) 26S subunit, non-ATPase, 8
chr3_+_69134080 9.73 ENST00000273258.3
ADP-ribosylation-like factor 6 interacting protein 5
chr3_-_81792780 9.50 ENST00000489715.1
glucan (1,4-alpha-), branching enzyme 1
chr22_-_45608324 9.46 ENST00000496226.1
ENST00000251993.7
KIAA0930
chr16_+_57662419 9.43 ENST00000388812.4
ENST00000538815.1
ENST00000456916.1
ENST00000567154.1
ENST00000388813.5
ENST00000562558.1
ENST00000566271.2
G protein-coupled receptor 56
chr18_-_55253871 9.42 ENST00000382873.3
ferrochelatase
chr12_+_75874460 9.41 ENST00000266659.3
GLI pathogenesis-related 1
chr19_+_18699599 9.20 ENST00000450195.2
chromosome 19 open reading frame 60
chr5_+_179125368 9.05 ENST00000502296.1
ENST00000504734.1
ENST00000415618.2
calnexin
chr17_-_28618948 8.99 ENST00000261714.6
bleomycin hydrolase
chr16_+_22308717 8.98 ENST00000299853.5
ENST00000564209.1
ENST00000565358.1
ENST00000418581.2
ENST00000564883.1
ENST00000359210.4
ENST00000563024.1
polymerase (RNA) III (DNA directed) polypeptide E (80kD)
chr2_+_122513109 8.82 ENST00000389682.3
ENST00000536142.1
translin
chr3_+_140660634 8.82 ENST00000446041.2
ENST00000507429.1
ENST00000324194.6
solute carrier family 25 (pyrimidine nucleotide carrier ), member 36
chr19_+_18496957 8.74 ENST00000252809.3
growth differentiation factor 15
chr14_-_65409502 8.55 ENST00000389614.5
glutathione peroxidase 2 (gastrointestinal)
chr17_+_18759612 8.54 ENST00000432893.2
ENST00000414602.1
ENST00000574522.1
ENST00000570450.1
ENST00000419071.2
phosphoribosyl pyrophosphate synthetase-associated protein 2
chr16_+_67261008 8.34 ENST00000304800.9
ENST00000563953.1
ENST00000565201.1
transmembrane protein 208
chr17_+_75372165 8.17 ENST00000427674.2
septin 9
chr3_+_140660743 8.01 ENST00000453248.2
solute carrier family 25 (pyrimidine nucleotide carrier ), member 36
chr11_-_2924970 7.94 ENST00000533594.1
solute carrier family 22 (organic cation transporter), member 18 antisense
chr11_+_35160709 7.94 ENST00000415148.2
ENST00000433354.2
ENST00000449691.2
ENST00000437706.2
ENST00000360158.4
ENST00000428726.2
ENST00000526669.2
ENST00000433892.2
ENST00000278386.6
ENST00000434472.2
ENST00000352818.4
ENST00000442151.2
CD44 molecule (Indian blood group)
chr16_+_57662138 7.86 ENST00000562414.1
ENST00000561969.1
ENST00000562631.1
ENST00000563445.1
ENST00000565338.1
ENST00000567702.1
G protein-coupled receptor 56
chr9_+_71819927 7.70 ENST00000535702.1
tight junction protein 2
chr3_-_98241358 7.68 ENST00000503004.1
ENST00000506575.1
ENST00000513452.1
ENST00000515620.1
claudin domain containing 1
chrX_+_51636629 7.48 ENST00000375722.1
ENST00000326587.7
ENST00000375695.2
melanoma antigen family D, 1
chr11_-_66103867 7.42 ENST00000424433.2
Ras and Rab interactor 1
chr9_+_71820057 7.41 ENST00000539225.1
tight junction protein 2
chr11_+_63448918 7.34 ENST00000341307.2
ENST00000356000.3
ENST00000542238.1
reticulon 3
chr7_+_101460882 7.32 ENST00000292535.7
ENST00000549414.2
ENST00000550008.2
ENST00000546411.2
ENST00000556210.1
cut-like homeobox 1
chr14_+_52456193 7.29 ENST00000261700.3
chromosome 14 open reading frame 166
chr1_+_45241109 7.21 ENST00000396651.3
ribosomal protein S8
chrX_-_153718953 7.17 ENST00000369649.4
ENST00000393586.1
solute carrier family 10, member 3
chr5_+_135385202 6.99 ENST00000514554.1
transforming growth factor, beta-induced, 68kDa
chr11_-_102668879 6.98 ENST00000315274.6
matrix metallopeptidase 1 (interstitial collagenase)
chr7_+_22766766 6.98 ENST00000426291.1
ENST00000401651.1
ENST00000258743.5
ENST00000420258.2
ENST00000407492.1
ENST00000401630.3
ENST00000406575.1
interleukin 6 (interferon, beta 2)
chr11_+_62649158 6.97 ENST00000539891.1
ENST00000536981.1
solute carrier family 3 (amino acid transporter heavy chain), member 2
chr6_-_24721054 6.90 ENST00000378119.4
chromosome 6 open reading frame 62
chr7_+_130794846 6.89 ENST00000421797.2
muskelin 1, intracellular mediator containing kelch motifs
chr7_-_102985035 6.76 ENST00000426036.2
ENST00000249270.7
ENST00000454277.1
ENST00000412522.1
DnaJ (Hsp40) homolog, subfamily C, member 2
chr14_-_75536182 6.72 ENST00000555463.1
acylphosphatase 1, erythrocyte (common) type
chr6_-_170862322 6.71 ENST00000262193.6
proteasome (prosome, macropain) subunit, beta type, 1
chr7_-_86849883 6.69 ENST00000433078.1
transmembrane protein 243, mitochondrial
chr3_+_69134124 6.68 ENST00000478935.1
ADP-ribosylation-like factor 6 interacting protein 5
chr1_+_84609944 6.61 ENST00000370685.3
protein kinase, cAMP-dependent, catalytic, beta
chr10_+_45495898 6.57 ENST00000298299.3
zinc finger protein 22
chr8_-_145013711 6.52 ENST00000345136.3
plectin
chr2_-_190044480 6.44 ENST00000374866.3
collagen, type V, alpha 2
chr22_-_32058166 6.40 ENST00000435900.1
ENST00000336566.4
phosphatidylserine decarboxylase
chr20_-_34330129 6.39 ENST00000397370.3
ENST00000528062.3
ENST00000407261.4
ENST00000374038.3
ENST00000361162.6
RNA binding motif protein 39
chr1_-_150208320 6.25 ENST00000534220.1
acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
chr22_-_39268192 6.03 ENST00000216083.6
chromobox homolog 6
chr19_+_17865011 6.01 ENST00000596462.1
ENST00000596865.1
ENST00000598960.1
ENST00000539407.1
FCH domain only 1
chr6_+_84569359 6.01 ENST00000369681.5
ENST00000369679.4
cytochrome b5 reductase 4
chr16_+_29819446 5.99 ENST00000568282.1
MYC-associated zinc finger protein (purine-binding transcription factor)
chr8_-_59572301 5.95 ENST00000038176.3
neutral sphingomyelinase (N-SMase) activation associated factor
chr3_-_149293990 5.95 ENST00000472417.1
WW domain containing transcription regulator 1
chr17_-_74733404 5.87 ENST00000508921.3
ENST00000583836.1
ENST00000358156.6
ENST00000392485.2
ENST00000359995.5
serine/arginine-rich splicing factor 2
chr15_-_59225844 5.81 ENST00000380516.2
SAFB-like, transcription modulator
chr18_+_11857439 5.58 ENST00000602628.1
guanine nucleotide binding protein (G protein), alpha activating activity polypeptide, olfactory type
chr16_+_30211181 5.56 ENST00000395138.2
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 3
chr17_+_21191341 5.51 ENST00000526076.2
ENST00000361818.5
ENST00000316920.6
mitogen-activated protein kinase kinase 3
chr19_+_6531010 5.51 ENST00000245817.3
tumor necrosis factor (ligand) superfamily, member 9
chr3_-_98241760 5.49 ENST00000507874.1
ENST00000502299.1
ENST00000508659.1
ENST00000510545.1
ENST00000511667.1
ENST00000394185.2
ENST00000394181.2
ENST00000508902.1
ENST00000341181.6
ENST00000437922.1
ENST00000394180.2
claudin domain containing 1
chr1_+_45241186 5.44 ENST00000372209.3
ribosomal protein S8
chr4_-_987217 5.37 ENST00000361661.2
ENST00000398516.2
solute carrier family 26 (anion exchanger), member 1
chr18_+_3252206 5.18 ENST00000578562.2
myosin, light chain 12A, regulatory, non-sarcomeric
chr12_+_75874580 5.16 ENST00000456650.3
GLI pathogenesis-related 1
chr16_-_11036300 4.94 ENST00000331808.4
Dexi homolog (mouse)
chr1_-_39339777 4.88 ENST00000397572.2
MYC binding protein
chr2_+_109237717 4.87 ENST00000409441.1
LIM and senescent cell antigen-like domains 1
chr9_+_140083099 4.53 ENST00000322310.5
Sjogren syndrome nuclear autoantigen 1
chr12_-_120687948 4.44 ENST00000458477.2
paxillin
chr1_+_81771806 4.24 ENST00000370721.1
ENST00000370727.1
ENST00000370725.1
ENST00000370723.1
ENST00000370728.1
ENST00000370730.1
latrophilin 2
chr17_-_76899275 4.11 ENST00000322630.2
ENST00000586713.1
Protein DDC8 homolog
chr20_-_43280361 4.10 ENST00000372874.4
adenosine deaminase
chr6_-_138428613 4.03 ENST00000421351.3
PERP, TP53 apoptosis effector
chr6_+_30034966 3.96 ENST00000376769.2
protein phosphatase 1, regulatory (inhibitor) subunit 11
chrX_-_72434628 3.86 ENST00000536638.1
ENST00000373517.3
nucleosome assembly protein 1-like 2
chr7_-_104909435 3.77 ENST00000357311.3
SRSF protein kinase 2
chr20_-_43280325 3.76 ENST00000537820.1
adenosine deaminase
chr22_+_22730353 3.73 ENST00000390296.2
immunoglobulin lambda variable 5-45
chr19_+_926000 3.67 ENST00000263620.3
AT rich interactive domain 3A (BRIGHT-like)
chr12_-_125401885 3.67 ENST00000542416.1
ubiquitin C
chr6_+_30034865 3.62 ENST00000376772.3
protein phosphatase 1, regulatory (inhibitor) subunit 11
chrX_-_119445263 3.50 ENST00000309720.5
transmembrane protein 255A
chrX_-_119445306 3.44 ENST00000371369.4
ENST00000440464.1
ENST00000519908.1
transmembrane protein 255A
chr4_+_183164574 3.39 ENST00000511685.1
teneurin transmembrane protein 3
chr18_-_12377283 3.35 ENST00000269143.3
AFG3-like AAA ATPase 2
chr11_+_65339820 3.31 ENST00000316409.2
ENST00000449319.2
ENST00000530349.1
family with sequence similarity 89, member B
chr16_+_12059091 3.01 ENST00000562385.1
tumor necrosis factor receptor superfamily, member 17
chr15_+_40531621 2.98 ENST00000560346.1
p21 protein (Cdc42/Rac)-activated kinase 6
chr17_+_74372662 2.94 ENST00000591651.1
ENST00000545180.1
sphingosine kinase 1
chr17_-_79604075 2.90 ENST00000374747.5
ENST00000539314.1
ENST00000331134.6
nuclear protein localization 4 homolog (S. cerevisiae)
chr9_-_74383799 2.84 ENST00000377044.4
transmembrane protein 2
chr16_-_73093597 2.83 ENST00000397992.5
zinc finger homeobox 3
chr11_+_46402297 2.75 ENST00000405308.2
midkine (neurite growth-promoting factor 2)

Network of associatons between targets according to the STRING database.

First level regulatory network of BACH1_NFE2_NFE2L2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
16.8 151.1 GO:0030091 protein repair(GO:0030091)
15.9 47.7 GO:1903070 negative regulation of ER-associated ubiquitin-dependent protein catabolic process(GO:1903070)
15.5 46.4 GO:0007518 myoblast fate determination(GO:0007518)
12.4 49.6 GO:1903660 negative regulation of complement-dependent cytotoxicity(GO:1903660)
11.1 44.4 GO:0006780 uroporphyrinogen III biosynthetic process(GO:0006780) uroporphyrinogen III metabolic process(GO:0046502)
11.1 44.3 GO:0051771 negative regulation of nitric-oxide synthase biosynthetic process(GO:0051771)
10.9 43.7 GO:1904386 response to thyroxine(GO:0097068) response to L-phenylalanine derivative(GO:1904386)
8.7 52.3 GO:0060316 positive regulation of ryanodine-sensitive calcium-release channel activity(GO:0060316)
7.9 31.6 GO:0009224 CMP salvage(GO:0006238) CMP biosynthetic process(GO:0009224) CMP metabolic process(GO:0046035)
7.7 23.1 GO:0070541 response to platinum ion(GO:0070541)
7.1 14.2 GO:0006097 glyoxylate cycle(GO:0006097)
6.8 34.2 GO:0045541 negative regulation of cholesterol biosynthetic process(GO:0045541) negative regulation of cholesterol metabolic process(GO:0090206)
6.7 699.1 GO:0006521 regulation of cellular amino acid metabolic process(GO:0006521)
6.1 48.7 GO:0006528 asparagine metabolic process(GO:0006528)
5.6 16.8 GO:1990519 pyrimidine nucleotide transport(GO:0006864) mitochondrial pyrimidine nucleotide import(GO:1990519)
5.5 49.5 GO:0001887 selenium compound metabolic process(GO:0001887)
4.9 14.7 GO:0031938 pre-replicative complex assembly involved in nuclear cell cycle DNA replication(GO:0006267) regulation of chromatin silencing at telomere(GO:0031938) pre-replicative complex assembly(GO:0036388) pre-replicative complex assembly involved in cell cycle DNA replication(GO:1902299)
4.9 29.2 GO:0006741 NADP biosynthetic process(GO:0006741)
4.6 18.3 GO:0043248 proteasome assembly(GO:0043248)
4.5 80.9 GO:0030388 fructose 1,6-bisphosphate metabolic process(GO:0030388)
4.5 40.4 GO:0035092 sperm chromatin condensation(GO:0035092)
4.3 12.9 GO:0016095 polyprenol catabolic process(GO:0016095)
4.1 37.2 GO:2000507 positive regulation of energy homeostasis(GO:2000507)
4.0 16.0 GO:1900186 negative regulation of clathrin-mediated endocytosis(GO:1900186)
3.8 30.6 GO:1902037 negative regulation of hematopoietic stem cell differentiation(GO:1902037)
3.6 14.4 GO:0010499 proteasomal ubiquitin-independent protein catabolic process(GO:0010499)
3.4 37.8 GO:0038203 TORC2 signaling(GO:0038203)
2.8 8.3 GO:0006624 vacuolar protein processing(GO:0006624)
2.6 7.9 GO:0046102 hypoxanthine salvage(GO:0043103) inosine metabolic process(GO:0046102)
2.3 7.0 GO:0002384 hepatic immune response(GO:0002384) response to prolactin(GO:1990637) regulation of STAT protein import into nucleus(GO:2000364) positive regulation of STAT protein import into nucleus(GO:2000366)
2.3 176.8 GO:0045454 cell redox homeostasis(GO:0045454)
2.3 6.8 GO:0051083 'de novo' cotranslational protein folding(GO:0051083)
2.1 17.1 GO:0018344 protein geranylgeranylation(GO:0018344)
2.1 21.3 GO:0006782 protoporphyrinogen IX biosynthetic process(GO:0006782)
2.1 28.8 GO:0070389 chaperone cofactor-dependent protein refolding(GO:0070389)
2.1 16.4 GO:0002036 regulation of L-glutamate transport(GO:0002036)
1.8 19.3 GO:0001731 formation of translation preinitiation complex(GO:0001731)
1.6 6.4 GO:1903224 regulation of endodermal cell differentiation(GO:1903224)
1.6 9.6 GO:0043418 homocysteine catabolic process(GO:0043418)
1.5 15.1 GO:0071847 TNFSF11-mediated signaling pathway(GO:0071847)
1.5 10.2 GO:0006642 triglyceride mobilization(GO:0006642)
1.4 7.0 GO:0060356 leucine import(GO:0060356)
1.4 5.5 GO:0045065 cytotoxic T cell differentiation(GO:0045065)
1.4 59.9 GO:0043486 histone exchange(GO:0043486)
1.3 6.6 GO:0097338 response to clozapine(GO:0097338)
1.2 7.3 GO:0031914 negative regulation of synaptic plasticity(GO:0031914)
1.1 37.5 GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent(GO:0002479)
1.1 4.5 GO:0060830 ciliary receptor clustering involved in smoothened signaling pathway(GO:0060830)
1.1 12.3 GO:0051599 response to hydrostatic pressure(GO:0051599)
1.1 12.9 GO:0061635 regulation of protein complex stability(GO:0061635)
1.1 5.4 GO:0050428 purine ribonucleoside bisphosphate biosynthetic process(GO:0034036) 3'-phosphoadenosine 5'-phosphosulfate biosynthetic process(GO:0050428)
1.0 7.9 GO:1900623 regulation of monocyte aggregation(GO:1900623) positive regulation of monocyte aggregation(GO:1900625)
1.0 2.9 GO:0046521 sphingoid catabolic process(GO:0046521)
0.9 7.3 GO:0071787 endoplasmic reticulum tubular network assembly(GO:0071787)
0.9 10.9 GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000463)
0.9 9.1 GO:0034975 protein folding in endoplasmic reticulum(GO:0034975)
0.9 2.7 GO:0071051 polyadenylation-dependent snoRNA 3'-end processing(GO:0071051)
0.8 49.4 GO:0030224 monocyte differentiation(GO:0030224)
0.8 3.3 GO:0060392 negative regulation of SMAD protein import into nucleus(GO:0060392)
0.8 2.4 GO:0002296 T-helper 1 cell lineage commitment(GO:0002296)
0.8 5.6 GO:0098989 NMDA selective glutamate receptor signaling pathway(GO:0098989)
0.8 3.9 GO:0071442 positive regulation of histone H3-K14 acetylation(GO:0071442) regulation of stem cell division(GO:2000035)
0.8 21.2 GO:0006884 cell volume homeostasis(GO:0006884)
0.8 4.5 GO:0070966 nuclear-transcribed mRNA catabolic process, no-go decay(GO:0070966)
0.8 3.8 GO:0035063 nuclear speck organization(GO:0035063)
0.7 2.8 GO:1904059 regulation of locomotor rhythm(GO:1904059)
0.7 2.1 GO:1901143 insulin catabolic process(GO:1901143)
0.7 5.5 GO:0035897 proteolysis in other organism(GO:0035897)
0.7 8.8 GO:0030422 production of siRNA involved in RNA interference(GO:0030422)
0.7 5.9 GO:0033197 response to vitamin E(GO:0033197)
0.6 7.3 GO:0006388 tRNA splicing, via endonucleolytic cleavage and ligation(GO:0006388)
0.6 6.6 GO:0072257 metanephric nephron tubule epithelial cell differentiation(GO:0072257) regulation of metanephric nephron tubule epithelial cell differentiation(GO:0072307)
0.6 13.5 GO:0034389 lipid particle organization(GO:0034389)
0.6 25.7 GO:0006363 termination of RNA polymerase I transcription(GO:0006363)
0.6 3.4 GO:0036444 calcium ion transmembrane import into mitochondrion(GO:0036444)
0.5 2.5 GO:1904977 lymphatic endothelial cell migration(GO:1904977)
0.5 10.2 GO:1901741 positive regulation of myoblast fusion(GO:1901741)
0.5 43.8 GO:0006695 cholesterol biosynthetic process(GO:0006695)
0.5 2.7 GO:0030421 defecation(GO:0030421)
0.4 12.3 GO:0072575 hepatocyte proliferation(GO:0072574) epithelial cell proliferation involved in liver morphogenesis(GO:0072575)
0.4 11.9 GO:0031581 hemidesmosome assembly(GO:0031581)
0.4 1.6 GO:0070494 regulation of thrombin receptor signaling pathway(GO:0070494) negative regulation of thrombin receptor signaling pathway(GO:0070495)
0.4 1.2 GO:0001180 transcription initiation from RNA polymerase I promoter for nuclear large rRNA transcript(GO:0001180)
0.4 1.6 GO:1901628 positive regulation of postsynaptic membrane organization(GO:1901628)
0.4 7.6 GO:0032515 negative regulation of phosphoprotein phosphatase activity(GO:0032515)
0.4 8.2 GO:1902857 positive regulation of nonmotile primary cilium assembly(GO:1902857)
0.4 4.0 GO:0002934 desmosome organization(GO:0002934)
0.4 2.2 GO:0046322 negative regulation of fatty acid oxidation(GO:0046322)
0.4 22.9 GO:0006120 mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
0.3 7.5 GO:0090190 positive regulation of branching involved in ureteric bud morphogenesis(GO:0090190)
0.3 30.4 GO:0070527 platelet aggregation(GO:0070527)
0.3 12.7 GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000462)
0.3 11.7 GO:0007094 mitotic spindle assembly checkpoint(GO:0007094) spindle assembly checkpoint(GO:0071173)
0.3 4.2 GO:0007191 adenylate cyclase-activating dopamine receptor signaling pathway(GO:0007191)
0.3 0.8 GO:0035606 peptidyl-cysteine S-trans-nitrosylation(GO:0035606)
0.3 2.9 GO:0039536 negative regulation of RIG-I signaling pathway(GO:0039536)
0.3 18.3 GO:0006611 protein export from nucleus(GO:0006611)
0.3 3.6 GO:0051151 negative regulation of smooth muscle cell differentiation(GO:0051151)
0.2 3.4 GO:0097264 self proteolysis(GO:0097264)
0.2 7.0 GO:0032461 positive regulation of protein oligomerization(GO:0032461)
0.2 1.7 GO:2000580 positive regulation of microtubule motor activity(GO:2000576) regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000580) positive regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000582)
0.2 2.5 GO:0015671 oxygen transport(GO:0015671)
0.2 2.8 GO:0030214 hyaluronan catabolic process(GO:0030214)
0.2 7.3 GO:0000301 retrograde transport, vesicle recycling within Golgi(GO:0000301)
0.2 4.4 GO:0007172 signal complex assembly(GO:0007172)
0.2 13.3 GO:0045604 regulation of epidermal cell differentiation(GO:0045604)
0.2 0.4 GO:0071109 superior temporal gyrus development(GO:0071109)
0.2 9.0 GO:0006383 transcription from RNA polymerase III promoter(GO:0006383)
0.2 4.9 GO:0009165 nucleotide biosynthetic process(GO:0009165)
0.2 47.9 GO:0007411 axon guidance(GO:0007411)
0.1 4.2 GO:0048268 clathrin coat assembly(GO:0048268)
0.1 6.0 GO:0015701 bicarbonate transport(GO:0015701)
0.1 4.9 GO:1900026 positive regulation of focal adhesion assembly(GO:0051894) positive regulation of substrate adhesion-dependent cell spreading(GO:1900026) positive regulation of adherens junction organization(GO:1903393)
0.1 0.4 GO:0038188 cholecystokinin signaling pathway(GO:0038188)
0.1 1.9 GO:0050855 regulation of B cell receptor signaling pathway(GO:0050855)
0.1 0.4 GO:0061086 negative regulation of histone H3-K27 methylation(GO:0061086)
0.1 0.6 GO:0090050 positive regulation of cell migration involved in sprouting angiogenesis(GO:0090050)
0.1 5.2 GO:0002260 lymphocyte homeostasis(GO:0002260)
0.1 1.1 GO:0006657 CDP-choline pathway(GO:0006657)
0.1 0.9 GO:0045329 carnitine biosynthetic process(GO:0045329)
0.1 2.9 GO:0015721 bile acid and bile salt transport(GO:0015721)
0.1 6.0 GO:0006369 termination of RNA polymerase II transcription(GO:0006369)
0.1 6.5 GO:0002062 chondrocyte differentiation(GO:0002062)
0.1 1.4 GO:0003417 growth plate cartilage development(GO:0003417)
0.1 0.7 GO:0051601 exocyst localization(GO:0051601)
0.1 1.1 GO:0043065 positive regulation of apoptotic process(GO:0043065)
0.1 6.6 GO:0042476 odontogenesis(GO:0042476)
0.1 1.7 GO:1900027 regulation of ruffle assembly(GO:1900027)
0.1 1.9 GO:0010738 regulation of protein kinase A signaling(GO:0010738)
0.1 8.2 GO:0007093 mitotic cell cycle checkpoint(GO:0007093)
0.1 0.2 GO:0045425 regulation of granulocyte macrophage colony-stimulating factor biosynthetic process(GO:0045423) positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process(GO:0045425)
0.1 0.5 GO:2000304 positive regulation of sphingolipid biosynthetic process(GO:0090154) positive regulation of ceramide biosynthetic process(GO:2000304)
0.1 1.3 GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580)
0.0 0.6 GO:0051823 regulation of synapse structural plasticity(GO:0051823)
0.0 5.8 GO:0050684 regulation of mRNA processing(GO:0050684)
0.0 6.3 GO:0010389 regulation of G2/M transition of mitotic cell cycle(GO:0010389)
0.0 2.4 GO:0005978 glycogen biosynthetic process(GO:0005978) glucan biosynthetic process(GO:0009250)
0.0 1.2 GO:2000144 positive regulation of DNA-templated transcription, initiation(GO:2000144)
0.0 0.2 GO:0070857 regulation of bile acid biosynthetic process(GO:0070857)
0.0 2.2 GO:0022900 electron transport chain(GO:0022900)
0.0 0.8 GO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0000083)
0.0 6.4 GO:0008380 RNA splicing(GO:0008380)
0.0 0.1 GO:0009642 response to light intensity(GO:0009642)
0.0 1.5 GO:0010977 negative regulation of neuron projection development(GO:0010977)
0.0 2.0 GO:0006805 xenobiotic metabolic process(GO:0006805)
0.0 1.2 GO:0031532 actin cytoskeleton reorganization(GO:0031532)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
30.4 364.7 GO:0019773 proteasome core complex, alpha-subunit complex(GO:0019773)
14.8 44.3 GO:0097057 TRAF2-GSTP1 complex(GO:0097057)
12.4 49.6 GO:0034751 aryl hydrocarbon receptor complex(GO:0034751)
8.7 87.5 GO:0008541 proteasome regulatory particle, lid subcomplex(GO:0008541)
7.3 79.9 GO:0031595 nuclear proteasome complex(GO:0031595)
6.4 25.7 GO:0070985 TFIIK complex(GO:0070985)
5.9 64.4 GO:0005838 proteasome regulatory particle(GO:0005838)
4.9 14.7 GO:0036387 nuclear pre-replicative complex(GO:0005656) pre-replicative complex(GO:0036387)
4.3 17.1 GO:0005968 Rab-protein geranylgeranyltransferase complex(GO:0005968)
3.4 72.2 GO:0000812 Swr1 complex(GO:0000812)
2.9 37.5 GO:0008385 IkappaB kinase complex(GO:0008385)
2.1 6.4 GO:0005588 collagen type V trimer(GO:0005588)
2.1 34.2 GO:0031045 dense core granule(GO:0031045)
2.1 8.5 GO:0002189 ribose phosphate diphosphokinase complex(GO:0002189)
2.1 37.8 GO:0031932 TORC2 complex(GO:0031932)
2.0 41.9 GO:0031229 integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229) nuclear membrane part(GO:0044453)
1.9 19.0 GO:0042584 chromaffin granule membrane(GO:0042584)
1.8 100.2 GO:0000502 proteasome complex(GO:0000502)
1.7 7.0 GO:0005896 interleukin-6 receptor complex(GO:0005896)
1.7 37.2 GO:0016281 eukaryotic translation initiation factor 4F complex(GO:0016281)
1.6 137.7 GO:1904724 tertiary granule lumen(GO:1904724)
1.2 5.9 GO:0035061 interchromatin granule(GO:0035061)
1.1 7.9 GO:0035692 macrophage migration inhibitory factor receptor complex(GO:0035692)
1.1 12.9 GO:0044754 autolysosome(GO:0044754)
1.0 7.3 GO:0072669 tRNA-splicing ligase complex(GO:0072669)
0.8 9.1 GO:0044233 ER-mitochondrion membrane contact site(GO:0044233)
0.8 28.8 GO:0005697 telomerase holoenzyme complex(GO:0005697)
0.6 4.5 GO:0070937 CRD-mediated mRNA stability complex(GO:0070937)
0.5 28.4 GO:0009295 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.4 7.6 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.4 21.4 GO:0043034 costamere(GO:0043034)
0.4 74.5 GO:0048770 melanosome(GO:0042470) pigment granule(GO:0048770)
0.4 9.0 GO:0005666 DNA-directed RNA polymerase III complex(GO:0005666)
0.4 10.9 GO:0030687 preribosome, large subunit precursor(GO:0030687)
0.3 22.9 GO:0005747 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.3 2.7 GO:0005610 laminin-5 complex(GO:0005610)
0.3 6.6 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.3 12.1 GO:0016592 mediator complex(GO:0016592)
0.3 47.5 GO:0001650 fibrillar center(GO:0001650)
0.3 40.4 GO:0016363 nuclear matrix(GO:0016363)
0.3 15.0 GO:0009986 cell surface(GO:0009986)
0.3 5.9 GO:0031105 septin complex(GO:0031105)
0.2 2.7 GO:0000176 nuclear exosome (RNase complex)(GO:0000176)
0.2 2.9 GO:0034098 VCP-NPL4-UFD1 AAA ATPase complex(GO:0034098)
0.2 14.4 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.2 87.1 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.2 12.7 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.2 64.3 GO:0009897 external side of plasma membrane(GO:0009897)
0.2 13.6 GO:0005903 brush border(GO:0005903)
0.2 23.7 GO:0030176 integral component of endoplasmic reticulum membrane(GO:0030176)
0.2 0.8 GO:0097452 GAIT complex(GO:0097452)
0.1 4.0 GO:0030057 desmosome(GO:0030057)
0.1 0.4 GO:0044224 juxtaparanode region of axon(GO:0044224)
0.1 13.3 GO:0000777 condensed chromosome kinetochore(GO:0000777)
0.1 32.6 GO:0030425 dendrite(GO:0030425)
0.1 6.5 GO:0031519 PcG protein complex(GO:0031519)
0.1 19.0 GO:0016607 nuclear speck(GO:0016607)
0.1 3.9 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.1 9.0 GO:0005923 bicellular tight junction(GO:0005923)
0.1 15.1 GO:0030027 lamellipodium(GO:0030027)
0.1 4.5 GO:0036064 ciliary basal body(GO:0036064)
0.1 4.2 GO:0005913 cell-cell adherens junction(GO:0005913)
0.1 4.1 GO:0005667 transcription factor complex(GO:0005667)
0.1 0.7 GO:0000145 exocyst(GO:0000145)
0.0 273.0 GO:0005829 cytosol(GO:0005829)
0.0 2.9 GO:0005604 basement membrane(GO:0005604)
0.0 1.0 GO:0035577 azurophil granule membrane(GO:0035577)
0.0 5.5 GO:0016604 nuclear body(GO:0016604)
0.0 0.3 GO:0071565 npBAF complex(GO:0071564) nBAF complex(GO:0071565)
0.0 3.3 GO:0005578 proteinaceous extracellular matrix(GO:0005578)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
25.1 176.0 GO:0047134 protein-disulfide reductase activity(GO:0047134)
23.0 68.9 GO:0004362 glutathione-disulfide reductase activity(GO:0004362)
17.4 52.3 GO:0050610 oxidoreductase activity, acting on a sulfur group of donors, quinone or similar compound as acceptor(GO:0016672) glutathione dehydrogenase (ascorbate) activity(GO:0045174) methylarsonate reductase activity(GO:0050610)
16.5 49.6 GO:0032551 pyrimidine nucleoside binding(GO:0001884) UTP binding(GO:0002134) sulfonylurea receptor binding(GO:0017098) pyrimidine ribonucleoside binding(GO:0032551)
16.5 49.5 GO:0098625 methylselenol reductase activity(GO:0098625) methylseleninic acid reductase activity(GO:0098626)
15.9 47.7 GO:0008192 RNA guanylyltransferase activity(GO:0008192)
15.6 46.8 GO:0050613 delta14-sterol reductase activity(GO:0050613)
13.0 390.3 GO:0070003 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
12.5 112.4 GO:0016721 superoxide dismutase activity(GO:0004784) oxidoreductase activity, acting on superoxide radicals as acceptor(GO:0016721)
8.9 44.3 GO:0070026 nitric oxide binding(GO:0070026)
8.4 67.5 GO:0008379 thioredoxin peroxidase activity(GO:0008379)
7.4 80.9 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
7.3 79.9 GO:0036402 proteasome-activating ATPase activity(GO:0036402)
7.2 28.8 GO:0050220 prostaglandin-E synthase activity(GO:0050220)
5.6 16.8 GO:0015218 pyrimidine nucleotide transmembrane transporter activity(GO:0015218)
4.9 29.2 GO:0008948 malate dehydrogenase (decarboxylating) (NAD+) activity(GO:0004471) malate dehydrogenase (decarboxylating) (NADP+) activity(GO:0004473) oxaloacetate decarboxylase activity(GO:0008948)
4.7 14.2 GO:0004450 isocitrate dehydrogenase (NADP+) activity(GO:0004450)
4.5 31.6 GO:0004849 uridine kinase activity(GO:0004849)
3.9 19.3 GO:0071074 eukaryotic initiation factor eIF2 binding(GO:0071074)
3.6 10.9 GO:0016435 rRNA (guanine) methyltransferase activity(GO:0016435)
3.4 17.1 GO:0004663 Rab geranylgeranyltransferase activity(GO:0004663)
3.4 6.7 GO:0003998 acylphosphatase activity(GO:0003998)
3.2 12.9 GO:0047718 indanol dehydrogenase activity(GO:0047718)
2.7 37.5 GO:0042975 peroxisome proliferator activated receptor binding(GO:0042975)
2.6 18.3 GO:0061133 endopeptidase activator activity(GO:0061133)
2.5 37.2 GO:0008190 eukaryotic initiation factor 4E binding(GO:0008190)
2.1 6.4 GO:0004609 phosphatidylserine decarboxylase activity(GO:0004609)
1.9 49.0 GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen(GO:0016702)
1.8 7.2 GO:0008508 bile acid:sodium symporter activity(GO:0008508)
1.5 35.4 GO:0016881 acid-amino acid ligase activity(GO:0016881)
1.5 79.7 GO:0019212 phosphatase inhibitor activity(GO:0019212)
1.4 8.5 GO:0004749 ribose phosphate diphosphokinase activity(GO:0004749)
1.1 6.8 GO:0061649 ubiquitinated histone binding(GO:0061649)
1.1 15.5 GO:0030215 semaphorin receptor binding(GO:0030215)
1.1 23.1 GO:0051537 2 iron, 2 sulfur cluster binding(GO:0051537)
1.1 25.7 GO:0008353 RNA polymerase II carboxy-terminal domain kinase activity(GO:0008353)
1.0 14.7 GO:0043138 3'-5' DNA helicase activity(GO:0043138)
1.0 7.9 GO:0004000 adenosine deaminase activity(GO:0004000)
0.9 5.6 GO:0047685 amine sulfotransferase activity(GO:0047685)
0.9 5.4 GO:0019531 oxalate transmembrane transporter activity(GO:0019531)
0.8 7.0 GO:0005138 interleukin-6 receptor binding(GO:0005138)
0.7 10.2 GO:0031957 very long-chain fatty acid-CoA ligase activity(GO:0031957)
0.7 12.9 GO:0070530 K63-linked polyubiquitin binding(GO:0070530)
0.7 7.0 GO:0005432 calcium:sodium antiporter activity(GO:0005432)
0.7 44.4 GO:0016836 hydro-lyase activity(GO:0016836)
0.6 9.4 GO:0004602 glutathione peroxidase activity(GO:0004602)
0.5 2.2 GO:0022865 transmembrane electron transfer carrier(GO:0022865)
0.5 6.0 GO:0004128 cytochrome-b5 reductase activity, acting on NAD(P)H(GO:0004128)
0.5 2.2 GO:0004466 long-chain-acyl-CoA dehydrogenase activity(GO:0004466)
0.5 89.1 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.5 2.9 GO:0017050 sphinganine kinase activity(GO:0008481) D-erythro-sphingosine kinase activity(GO:0017050)
0.5 22.9 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.5 22.0 GO:0008536 Ran GTPase binding(GO:0008536)
0.4 4.4 GO:0017166 vinculin binding(GO:0017166)
0.4 9.2 GO:0030506 ankyrin binding(GO:0030506)
0.4 9.1 GO:0034185 apolipoprotein binding(GO:0034185)
0.4 6.0 GO:0035612 AP-2 adaptor complex binding(GO:0035612)
0.4 6.6 GO:0004691 cAMP-dependent protein kinase activity(GO:0004691)
0.4 17.1 GO:0016831 carboxy-lyase activity(GO:0016831)
0.4 1.2 GO:0001181 transcription factor activity, core RNA polymerase I binding(GO:0001181)
0.4 9.0 GO:0001056 RNA polymerase III activity(GO:0001056)
0.4 2.1 GO:0072320 volume-sensitive chloride channel activity(GO:0072320)
0.4 14.9 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.3 4.1 GO:0008140 cAMP response element binding protein binding(GO:0008140)
0.3 10.4 GO:0004385 guanylate kinase activity(GO:0004385)
0.3 7.3 GO:0000993 RNA polymerase II core binding(GO:0000993)
0.3 2.1 GO:0043559 insulin binding(GO:0043559)
0.3 2.8 GO:0004415 hyalurononglucosaminidase activity(GO:0004415)
0.2 20.1 GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups(GO:0016765)
0.2 12.9 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.2 0.9 GO:0008336 gamma-butyrobetaine dioxygenase activity(GO:0008336)
0.2 1.1 GO:0004105 choline-phosphate cytidylyltransferase activity(GO:0004105)
0.2 3.3 GO:0001222 transcription corepressor binding(GO:0001222)
0.2 0.8 GO:0004365 glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity(GO:0004365) aspartic-type endopeptidase inhibitor activity(GO:0019828) glyceraldehyde-3-phosphate dehydrogenase (NAD(P)+) (phosphorylating) activity(GO:0043891)
0.2 21.8 GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides(GO:0016811)
0.2 2.5 GO:0005344 oxygen transporter activity(GO:0005344)
0.2 9.6 GO:0004180 carboxypeptidase activity(GO:0004180)
0.2 5.6 GO:0031683 G-protein beta/gamma-subunit complex binding(GO:0031683)
0.2 36.9 GO:0000287 magnesium ion binding(GO:0000287)
0.2 11.6 GO:0097110 scaffold protein binding(GO:0097110)
0.2 2.0 GO:0000774 adenyl-nucleotide exchange factor activity(GO:0000774)
0.1 5.9 GO:0005080 protein kinase C binding(GO:0005080)
0.1 6.1 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.1 2.0 GO:0017162 aryl hydrocarbon receptor binding(GO:0017162)
0.1 7.3 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.1 8.7 GO:0005160 transforming growth factor beta receptor binding(GO:0005160)
0.1 2.4 GO:0001046 core promoter sequence-specific DNA binding(GO:0001046)
0.1 0.4 GO:0004951 cholecystokinin receptor activity(GO:0004951)
0.1 1.3 GO:0033038 bitter taste receptor activity(GO:0033038)
0.1 0.5 GO:0016230 sphingomyelin phosphodiesterase activator activity(GO:0016230)
0.1 1.9 GO:0034237 protein kinase A regulatory subunit binding(GO:0034237)
0.1 7.0 GO:0050840 extracellular matrix binding(GO:0050840)
0.1 3.9 GO:0048365 Rac GTPase binding(GO:0048365)
0.1 1.2 GO:0097109 neuroligin family protein binding(GO:0097109)
0.1 8.4 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979)
0.1 2.7 GO:0000175 3'-5'-exoribonuclease activity(GO:0000175)
0.1 8.8 GO:0004519 endonuclease activity(GO:0004519)
0.1 6.2 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.1 6.0 GO:0003727 single-stranded RNA binding(GO:0003727)
0.1 2.6 GO:0030971 receptor tyrosine kinase binding(GO:0030971)
0.1 12.7 GO:0003735 structural constituent of ribosome(GO:0003735)
0.0 9.5 GO:0016758 transferase activity, transferring hexosyl groups(GO:0016758)
0.0 0.9 GO:0004708 MAP kinase kinase activity(GO:0004708)
0.0 1.2 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.0 0.1 GO:0004656 procollagen-proline 4-dioxygenase activity(GO:0004656) procollagen-proline dioxygenase activity(GO:0019798)
0.0 4.5 GO:0030674 protein binding, bridging(GO:0030674)
0.0 0.1 GO:0008273 calcium, potassium:sodium antiporter activity(GO:0008273)
0.0 7.8 GO:0003682 chromatin binding(GO:0003682)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
3.6 145.8 PID P38 MKK3 6PATHWAY p38 MAPK signaling pathway
1.8 25.7 SA G2 AND M PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
1.8 119.1 PID AURORA B PATHWAY Aurora B signaling
1.2 34.5 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling
1.1 97.0 PID TAP63 PATHWAY Validated transcriptional targets of TAp63 isoforms
0.9 104.0 PID HIF1 TFPATHWAY HIF-1-alpha transcription factor network
0.9 59.3 ST B CELL ANTIGEN RECEPTOR B Cell Antigen Receptor
0.9 12.3 SA B CELL RECEPTOR COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
0.7 36.9 PID HDAC CLASSII PATHWAY Signaling events mediated by HDAC Class II
0.6 17.1 PID PRL SIGNALING EVENTS PATHWAY Signaling events mediated by PRL
0.6 2.5 SA PTEN PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.6 40.6 PID HNF3A PATHWAY FOXA1 transcription factor network
0.6 55.9 PID VEGFR1 2 PATHWAY Signaling events mediated by VEGFR1 and VEGFR2
0.6 39.0 PID MTOR 4PATHWAY mTOR signaling pathway
0.5 49.1 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation
0.4 7.0 ST STAT3 PATHWAY STAT3 Pathway
0.4 7.9 PID AVB3 OPN PATHWAY Osteopontin-mediated events
0.4 28.8 PID TELOMERASE PATHWAY Regulation of Telomerase
0.4 12.4 PID IL1 PATHWAY IL1-mediated signaling events
0.3 7.2 PID GMCSF PATHWAY GMCSF-mediated signaling events
0.3 13.5 PID P38 ALPHA BETA DOWNSTREAM PATHWAY Signaling mediated by p38-alpha and p38-beta
0.2 14.4 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.2 14.8 PID SYNDECAN 1 PATHWAY Syndecan-1-mediated signaling events
0.2 2.8 PID LPA4 PATHWAY LPA4-mediated signaling events
0.2 2.4 ST INTERLEUKIN 4 PATHWAY Interleukin 4 (IL-4) Pathway
0.2 2.7 PID INTEGRIN4 PATHWAY Alpha6 beta4 integrin-ligand interactions
0.2 9.8 PID NFAT TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.1 2.9 PID S1P META PATHWAY Sphingosine 1-phosphate (S1P) pathway
0.1 5.0 PID ILK PATHWAY Integrin-linked kinase signaling
0.1 4.4 PID INTEGRIN1 PATHWAY Beta1 integrin cell surface interactions
0.1 2.0 PID RET PATHWAY Signaling events regulated by Ret tyrosine kinase
0.1 3.9 SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES Genes related to regulation of the actin cytoskeleton
0.1 1.9 PID IL2 STAT5 PATHWAY IL2 signaling events mediated by STAT5
0.1 14.0 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1 4.9 PID NOTCH PATHWAY Notch signaling pathway
0.1 5.3 PID ERBB1 DOWNSTREAM PATHWAY ErbB1 downstream signaling
0.0 2.2 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 2.9 PID P75 NTR PATHWAY p75(NTR)-mediated signaling
0.0 1.6 PID CXCR4 PATHWAY CXCR4-mediated signaling events
0.0 3.7 PID P53 DOWNSTREAM PATHWAY Direct p53 effectors
0.0 1.1 PID E2F PATHWAY E2F transcription factor network
0.0 0.5 PID TNF PATHWAY TNF receptor signaling pathway

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
10.6 200.7 REACTOME THE NLRP3 INFLAMMASOME Genes involved in The NLRP3 inflammasome
9.0 699.1 REACTOME REGULATION OF ORNITHINE DECARBOXYLASE ODC Genes involved in Regulation of ornithine decarboxylase (ODC)
4.1 111.5 REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY Genes involved in Post-chaperonin tubulin folding pathway
4.0 140.4 REACTOME GLUTATHIONE CONJUGATION Genes involved in Glutathione conjugation
3.6 116.1 REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
3.3 88.7 REACTOME METABOLISM OF PORPHYRINS Genes involved in Metabolism of porphyrins
3.1 37.5 REACTOME IKK COMPLEX RECRUITMENT MEDIATED BY RIP1 Genes involved in IKK complex recruitment mediated by RIP1
1.8 37.2 REACTOME MTORC1 MEDIATED SIGNALLING Genes involved in mTORC1-mediated signalling
1.6 81.7 REACTOME GLYCOLYSIS Genes involved in Glycolysis
1.5 46.8 REACTOME CHOLESTEROL BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
1.1 12.4 REACTOME NFKB IS ACTIVATED AND SIGNALS SURVIVAL Genes involved in NF-kB is activated and signals survival
1.0 10.2 REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24 HYDROXYCHOLESTEROL Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol
1.0 25.7 REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION Genes involved in Cyclin A/B1 associated events during G2/M transition
0.9 14.7 REACTOME UNWINDING OF DNA Genes involved in Unwinding of DNA
0.9 31.6 REACTOME PYRIMIDINE METABOLISM Genes involved in Pyrimidine metabolism
0.8 15.1 REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS Genes involved in Apoptotic cleavage of cell adhesion proteins
0.6 7.5 REACTOME ROLE OF DCC IN REGULATING APOPTOSIS Genes involved in Role of DCC in regulating apoptosis
0.5 9.1 REACTOME CALNEXIN CALRETICULIN CYCLE Genes involved in Calnexin/calreticulin cycle
0.5 30.6 REACTOME MITOCHONDRIAL PROTEIN IMPORT Genes involved in Mitochondrial Protein Import
0.5 14.2 REACTOME PEROXISOMAL LIPID METABOLISM Genes involved in Peroxisomal lipid metabolism
0.5 5.6 REACTOME ADENYLATE CYCLASE ACTIVATING PATHWAY Genes involved in Adenylate cyclase activating pathway
0.4 7.6 REACTOME IL 6 SIGNALING Genes involved in Interleukin-6 signaling
0.4 7.9 REACTOME HYALURONAN UPTAKE AND DEGRADATION Genes involved in Hyaluronan uptake and degradation
0.4 12.3 REACTOME ERK MAPK TARGETS Genes involved in ERK/MAPK targets
0.4 9.0 REACTOME RNA POL III CHAIN ELONGATION Genes involved in RNA Polymerase III Chain Elongation
0.4 49.9 REACTOME PPARA ACTIVATES GENE EXPRESSION Genes involved in PPARA Activates Gene Expression
0.3 5.5 REACTOME ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION Genes involved in activated TAK1 mediates p38 MAPK activation
0.3 2.7 REACTOME MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE Genes involved in mRNA Decay by 3' to 5' Exoribonuclease
0.3 9.2 REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.3 22.9 REACTOME RESPIRATORY ELECTRON TRANSPORT Genes involved in Respiratory electron transport
0.3 7.0 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.3 6.6 REACTOME PKA MEDIATED PHOSPHORYLATION OF CREB Genes involved in PKA-mediated phosphorylation of CREB
0.2 7.3 REACTOME SIGNALING BY FGFR1 FUSION MUTANTS Genes involved in Signaling by FGFR1 fusion mutants
0.2 1.5 REACTOME RAP1 SIGNALLING Genes involved in Rap1 signalling
0.2 5.6 REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES Genes involved in Cytosolic sulfonation of small molecules
0.2 4.9 REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.2 12.7 REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.2 3.9 REACTOME ACTIVATION OF RAC Genes involved in Activation of Rac
0.1 5.9 REACTOME MRNA 3 END PROCESSING Genes involved in mRNA 3'-end processing
0.1 2.2 REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.1 19.3 REACTOME TRANSLATION Genes involved in Translation
0.1 14.0 REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 Genes involved in Response to elevated platelet cytosolic Ca2+
0.1 7.0 REACTOME AMYLOIDS Genes involved in Amyloids
0.1 6.2 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation
0.1 13.6 REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.1 2.9 REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.1 3.1 REACTOME BASIGIN INTERACTIONS Genes involved in Basigin interactions
0.1 5.5 REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.0 8.7 REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.0 1.2 REACTOME RNA POL I TRANSCRIPTION INITIATION Genes involved in RNA Polymerase I Transcription Initiation
0.0 1.1 REACTOME SYNTHESIS OF PC Genes involved in Synthesis of PC
0.0 2.7 REACTOME CELL JUNCTION ORGANIZATION Genes involved in Cell junction organization
0.0 0.2 REACTOME NOTCH HLH TRANSCRIPTION PATHWAY Genes involved in Notch-HLH transcription pathway
0.0 1.7 REACTOME MHC CLASS II ANTIGEN PRESENTATION Genes involved in MHC class II antigen presentation
0.0 0.2 REACTOME CD28 DEPENDENT VAV1 PATHWAY Genes involved in CD28 dependent Vav1 pathway