Motif ID: ADNP_IRX_SIX_ZHX.p2

Z-value: 0.999


Transcription factors associated with ADNP_IRX_SIX_ZHX.p2:

Gene SymbolEntrez IDGene Name
ADNP 23394 activity-dependent neuroprotector homeobox
IRX4 50805 iroquois homeobox 4
IRX5 10265 iroquois homeobox 5
SIX2 10736 SIX homeobox 2
SIX5 147912 SIX homeobox 5
ZHX1 11244 zinc fingers and homeoboxes 1
ZHX2 22882 zinc fingers and homeoboxes 2
ZHX3 23051 zinc fingers and homeoboxes 3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.p-valuePlot
ZHX1chr8_-_1242864890.572.7e-03Click!
ZHX3chr20_-_399287080.501.0e-02Click!
ADNPchr20_-_495474510.481.6e-02Click!
IRX5chr16_+_54965110-0.376.9e-02Click!
ZHX2chr8_+_123793988,
chr8_+_123794043
-0.262.2e-01Click!
SIX2chr2_-_45236521-0.125.6e-01Click!
IRX4chr5_-_1882764-0.096.6e-01Click!
SIX5chr19_-_46272496-0.019.5e-01Click!


Activity profile for motif ADNP_IRX_SIX_ZHX.p2.

activity profile for motif ADNP_IRX_SIX_ZHX.p2


Sorted Z-values histogram for motif ADNP_IRX_SIX_ZHX.p2

Sorted Z-values for motif ADNP_IRX_SIX_ZHX.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of ADNP_IRX_SIX_ZHX.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr4_+_41614911 7.333 NM_001112719
NM_001112720
LIMCH1

LIM and calponin homology domains 1

chr4_+_41700736 6.490 LIMCH1
LIM and calponin homology domains 1
chr1_+_61869699 5.930 NFIA
nuclear factor I/A
chr9_-_14086901 5.890 NFIB
nuclear factor I/B
chr4_+_41614725 5.672 LIMCH1
LIM and calponin homology domains 1
chr1_+_84630014 4.834 NM_001242857
NM_001242858
NM_001242859
PRKACB


protein kinase, cAMP-dependent, catalytic, beta


chr4_+_41614933 4.377 LIMCH1
LIM and calponin homology domains 1
chr1_+_84630575 3.297 NM_001242860
NM_001242861
PRKACB

protein kinase, cAMP-dependent, catalytic, beta

chr1_+_84630374 2.739 PRKACB
protein kinase, cAMP-dependent, catalytic, beta
chr3_+_132316080 2.324 NM_016557
CCRL1
chemokine (C-C motif) receptor-like 1
chr10_+_5136556 2.272 NM_003739
AKR1C3
aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II)
chr15_+_25281105 2.200 SNRPN
small nuclear ribonucleoprotein polypeptide N
chr10_+_5136613 2.172 AKR1C3
aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II)
chr6_-_76203256 2.163 NM_015687
FILIP1
filamin A interacting protein 1
chr1_+_78470593 2.156 NM_007034
DNAJB4
DnaJ (Hsp40) homolog, subfamily B, member 4
chr9_+_2015218 2.142 NM_003070
NM_139045
SMARCA2

SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2

chr10_+_5136589 2.081 AKR1C3
aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II)
chr11_-_33913835 2.044 NM_005574
LMO2
LIM domain only 2 (rhombotin-like 1)
chr12_+_20963637 2.022 NM_019844
SLCO1B3
solute carrier organic anion transporter family, member 1B3
chr5_-_111312522 1.931 NM_001142474
NM_001142475
C5orf13

chromosome 5 open reading frame 13

chrX_+_28605558 1.920 NM_014271
IL1RAPL1
interleukin 1 receptor accessory protein-like 1
chr4_+_140587086 1.878 MGST2
microsomal glutathione S-transferase 2
chr19_+_39899749 1.874


chr11_-_71746966 1.864


chr1_+_61547388 1.843 NM_001145512
NFIA
nuclear factor I/A
chr4_-_101439071 1.839 NM_001159694
NM_016242
EMCN

endomucin

chr9_-_75567915 1.774 ALDH1A1
aldehyde dehydrogenase 1 family, member A1
chr7_+_115863004 1.666 NM_152829
TES
testis derived transcript (3 LIM domains)
chr2_+_173686314 1.657 NM_001100397
RAPGEF4
Rap guanine nucleotide exchange factor (GEF) 4
chr3_-_18480203 1.634 NM_001131010
SATB1
SATB homeobox 1
chr4_-_16900028 1.588 LDB2
LIM domain binding 2
chr11_+_125034558 1.552 NM_022062
PKNOX2
PBX/knotted 1 homeobox 2
chr3_-_64211111 1.534 NM_198859
PRICKLE2
prickle homolog 2 (Drosophila)
chr4_-_70626429 1.455 NM_014465
SULT1B1
sulfotransferase family, cytosolic, 1B, member 1
chr11_+_87032428 1.411 TMEM135
transmembrane protein 135
chr3_-_114478117 1.377 NM_001164344
NM_001164345
ZBTB20

zinc finger and BTB domain containing 20

chr4_-_16900348 1.348 NM_001130834
NM_001290
LDB2

LIM domain binding 2

chr4_-_70725792 1.335 NM_005420
SULT1E1
sulfotransferase family 1E, estrogen-preferring, member 1
chr8_-_93075190 1.328 NM_004349
RUNX1T1
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
chr7_-_27183225 1.295 NM_019102
HOXA5
homeobox A5
chr2_-_183387063 1.270 NM_005019
NM_001003683
PDE1A

phosphodiesterase 1A, calmodulin-dependent

chr18_-_53089722 1.261 NM_001243233
TCF4
transcription factor 4
chr1_+_84647342 1.244 NM_001242862
PRKACB
protein kinase, cAMP-dependent, catalytic, beta
chr4_-_186577858 1.244 SORBS2
sorbin and SH3 domain containing 2
chrX_-_119709618 1.240 NM_003588
CUL4B
cullin 4B
chr7_+_89843133 1.229 NM_001040666
STEAP2
STEAP family member 2, metalloreductase
chr8_-_17752847 1.228 NM_147203
NM_201553
NM_004467
NM_201552
FGL1



fibrinogen-like 1



chr1_+_84768333 1.212 NM_001134664
SAMD13
sterile alpha motif domain containing 13
chr14_+_100563817 1.190 EVL
Enah/Vasp-like
chr1_+_76540374 1.188 NM_001160011
NM_152996
ST6GALNAC3

ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3

chr18_-_46469118 1.183 NM_001190823
SMAD7
SMAD family member 7
chr17_-_67138013 1.179 NM_080284
ABCA6
ATP-binding cassette, sub-family A (ABC1), member 6
chrX_-_19817854 1.172 SH3KBP1
SH3-domain kinase binding protein 1
chr1_+_212475147 1.130 NM_001199756
PPP2R5A
protein phosphatase 2, regulatory subunit B', alpha
chr5_-_88199868 1.117 NM_001131005
NM_001193347
MEF2C

myocyte enhancer factor 2C

chr4_-_186732208 1.095 NM_001145671
SORBS2
sorbin and SH3 domain containing 2
chr1_+_84767288 1.077 NM_001134663
SAMD13
sterile alpha motif domain containing 13
chrX_-_135863104 1.071 ARHGEF6
Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
chr4_-_163085117 1.056 NM_001128427
NM_001128428
NM_020116
FSTL5


follistatin-like 5


chrX_-_117119282 1.047 NM_001168299
KLHL13
kelch-like 13 (Drosophila)
chr9_-_8733893 1.012 NM_001040712
NM_001171025
NM_130391
NM_130392
NM_130393
PTPRD




protein tyrosine phosphatase, receptor type, D




chr10_+_83637442 1.011 NM_001165973
NRG3
neuregulin 3
chr8_-_93107442 0.992 NM_001198629
NM_001198630
NM_001198632
NM_175635
RUNX1T1



runt-related transcription factor 1; translocated to, 1 (cyclin D-related)



chr7_-_11871735 0.979 NM_015204
THSD7A
thrombospondin, type I, domain containing 7A
chrX_-_135863033 0.977 ARHGEF6
Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
chr8_-_93111915 0.976 NM_001198628
RUNX1T1
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
chr4_+_140586921 0.966 NM_001204366
NM_001204367
NM_001204368
NM_002413
MGST2



microsomal glutathione S-transferase 2



chr2_-_87248942 0.952 NM_002665
NM_001032392
PLGLB2
PLGLB1
plasminogen-like B2
plasminogen-like B1
chr6_+_155538096 0.941 NM_001010927
TIAM2
T-cell lymphoma invasion and metastasis 2
chr5_+_68800003 0.930 NM_001205255
OCLN
occludin
chr6_+_136172802 0.928 NM_018945
PDE7B
phosphodiesterase 7B
chr11_-_27742224 0.926 NM_001143805
NM_001143806
NM_170732
BDNF


brain-derived neurotrophic factor


chr5_+_61874561 0.924 NM_181506
LRRC70
leucine rich repeat containing 70
chr9_-_14398981 0.922 NM_001190738
NFIB
nuclear factor I/B
chr1_+_153747767 0.895 NM_024330
SLC27A3
solute carrier family 27 (fatty acid transporter), member 3
chr6_+_144612872 0.895 NM_007124
UTRN
utrophin
chr3_+_132318980 0.882 NM_178445
CCRL1
chemokine (C-C motif) receptor-like 1
chr1_+_164818083 0.879 PBX1
pre-B-cell leukemia homeobox 1
chr3_-_141747434 0.878 NM_001178141
NM_001178142
NM_006286
TFDP2


transcription factor Dp-2 (E2F dimerization partner 2)


chr16_+_20775311 0.870 NM_005622
NM_202000
ACSM3

acyl-CoA synthetase medium-chain family member 3

chr5_-_111091947 0.868 NM_001142483
C5orf13
chromosome 5 open reading frame 13
chr2_+_179184970 0.868 NM_145739
OSBPL6
oxysterol binding protein-like 6
chr2_+_200323088 0.837


chr2_-_133429069 0.835 NM_001077427
LYPD1
LY6/PLAUR domain containing 1
chr7_-_100425035 0.831 NM_004444
EPHB4
EPH receptor B4
chr13_+_103459495 0.825 NM_001204425
BIVM-ERCC5
BIVM
BIVM-ERCC5 readthrough
basic, immunoglobulin-like variable motif containing
chr10_-_17171789 0.824 NM_001081
CUBN
cubilin (intrinsic factor-cobalamin receptor)
chr6_-_79675672 0.815 PHIP
pleckstrin homology domain interacting protein
chr12_-_7848324 0.814 NM_020634
GDF3
growth differentiation factor 3
chr1_+_52082545 0.806 NM_024586
NM_148906
NM_148908
NM_148909
OSBPL9



oxysterol binding protein-like 9



chr17_-_66951381 0.802 NM_007168
ABCA8
ATP-binding cassette, sub-family A (ABC1), member 8
chr8_-_93029864 0.802 NM_175636
RUNX1T1
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
chr14_+_68168602 0.796 NM_152443
RDH12
retinol dehydrogenase 12 (all-trans/9-cis/11-cis)
chr3_-_18466759 0.795 NM_001195470
NM_002971
SATB1

SATB homeobox 1

chr3_-_165555167 0.791 BCHE
butyrylcholinesterase
chr9_+_130860816 0.781 NM_052901
NM_001006643
SLC25A25

solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 25

chr19_-_48752921 0.781 NM_001184901
NM_001184903
NM_014959
CARD8


caspase recruitment domain family, member 8


chr9_+_130860769 0.778 SLC25A25
solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 25
chr7_-_27166638 0.762 NM_153631
HOXA3
homeobox A3
chr13_+_36050885 0.755 NM_001204197
NBEA
neurobeachin
chr18_-_45663667 0.751 NM_001039360
ZBTB7C
zinc finger and BTB domain containing 7C
chr17_-_67057046 0.750 NM_080283
ABCA9
ATP-binding cassette, sub-family A (ABC1), member 9
chr8_-_93115453 0.749 NM_001198633
NM_175634
RUNX1T1

runt-related transcription factor 1; translocated to, 1 (cyclin D-related)

chr12_+_29376596 0.747 NM_018099
FAR2
fatty acyl CoA reductase 2
chr2_-_10942642 0.739 PDIA6
protein disulfide isomerase family A, member 6
chr11_+_101983170 0.736 NM_001195045
YAP1
Yes-associated protein 1
chr10_-_116392099 0.728 ABLIM1
actin binding LIM protein 1
chr1_+_64088886 0.726 NM_001172818
PGM1
phosphoglucomutase 1
chr2_+_33738941 0.724 NM_015376
RASGRP3
RAS guanyl releasing protein 3 (calcium and DAG-regulated)
chr5_-_95158465 0.717 NM_001118890
NM_001243658
NM_001243659
NM_002064
GLRX



glutaredoxin (thioltransferase)



chr5_-_168271852 0.711


chr2_+_88047603 0.702 NM_002665
NM_001032392
PLGLB2
PLGLB1
plasminogen-like B2
plasminogen-like B1
chr4_-_46996423 0.694 NM_000809
GABRA4
gamma-aminobutyric acid (GABA) A receptor, alpha 4
chr12_-_11150473 0.692 NM_176889
TAS2R20
taste receptor, type 2, member 20
chr3_+_25470067 0.687 RARB
retinoic acid receptor, beta
chr7_+_80275634 0.684 NM_001127443
NM_001127444
CD36

CD36 molecule (thrombospondin receptor)

chr21_-_39870303 0.676 NM_001136155
NM_182918
ERG

v-ets erythroblastosis virus E26 oncogene homolog (avian)

chr13_+_53035227 0.675 CKAP2
cytoskeleton associated protein 2
chr7_-_86595203 0.673 NM_152748
KIAA1324L
KIAA1324-like
chr3_-_69037498 0.672 C3orf64
chromosome 3 open reading frame 64
chr16_+_82068830 0.666 NM_002153
HSD17B2
hydroxysteroid (17-beta) dehydrogenase 2
chr11_+_92085261 0.663 NM_001008781
FAT3
FAT tumor suppressor homolog 3 (Drosophila)
chr8_-_6420454 0.660 NM_001118887
NM_001118888
NM_001147
ANGPT2


angiopoietin 2


chr5_-_39394423 0.658 DAB2
disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)
chr9_+_120466607 0.655 TLR4
toll-like receptor 4
chr5_-_95158365 0.652 GLRX
glutaredoxin (thioltransferase)
chr6_+_132873829 0.650 NM_053278
TAAR8
trace amine associated receptor 8
chr16_+_82068958 0.647 HSD17B2
hydroxysteroid (17-beta) dehydrogenase 2
chr11_-_27722599 0.645 NM_001143808
NM_001143809
NM_001143810
NM_001143811
BDNF



brain-derived neurotrophic factor



chr16_+_82068910 0.641 HSD17B2
hydroxysteroid (17-beta) dehydrogenase 2
chrX_-_19817907 0.641 NM_001024666
SH3KBP1
SH3-domain kinase binding protein 1
chr15_+_57511616 0.639 NM_207040
TCF12
transcription factor 12
chr12_-_10021932 0.638 CLEC2B
C-type lectin domain family 2, member B
chr17_+_3377346 0.635 NM_001128085
ASPA
aspartoacylase
chr12_+_14538232 0.632 ATF7IP
activating transcription factor 7 interacting protein
chr2_-_44586854 0.626 NM_001042385
NM_001042386
PREPL

prolyl endopeptidase-like

chr9_-_124989755 0.622 NM_001242334
LHX6
LIM homeobox 6
chr3_-_128294928 0.619 NM_007354
C3orf27
chromosome 3 open reading frame 27
chr4_-_186733372 0.614 NM_003603
NM_001145670
SORBS2

sorbin and SH3 domain containing 2

chr17_-_46651809 0.614 NM_002146
HOXB3
homeobox B3
chr18_-_53303129 0.607 NM_001243226
TCF4
transcription factor 4
chr10_+_5005685 0.604 AKR1C1
aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase)
chr14_-_38725253 0.601 CLEC14A
C-type lectin domain family 14, member A
chr12_+_93963597 0.596 NM_003877
SOCS2
suppressor of cytokine signaling 2
chr2_-_211018294 0.595 C2orf67
chromosome 2 open reading frame 67
chr1_-_197552304 0.592 DENND1B
DENN/MADD domain containing 1B
chr16_+_8806825 0.590 NM_000663
ABAT
4-aminobutyrate aminotransferase
chr7_-_26232148 0.590 HNRNPA2B1
heterogeneous nuclear ribonucleoprotein A2/B1
chr20_-_34117447 0.583 NM_001145350
C20orf173
chromosome 20 open reading frame 173
chr5_+_73109342 0.577 NM_001244364
RGNEF
190 kDa guanine nucleotide exchange factor
chr1_-_110933635 0.572 SLC16A4
solute carrier family 16, member 4 (monocarboxylic acid transporter 5)
chr10_+_35426709 0.571 NM_183011
NM_183012
CREM

cAMP responsive element modulator

chrX_+_85517970 0.571 NM_001139515
DACH2
dachshund homolog 2 (Drosophila)
chr8_-_74659942 0.569 NM_001164384
STAU2
staufen, RNA binding protein, homolog 2 (Drosophila)
chr3_-_165555252 0.569 NM_000055
BCHE
butyrylcholinesterase
chr10_-_126716452 0.562 NM_022802
CTBP2
C-terminal binding protein 2
chr2_+_189839132 0.562 COL3A1
collagen, type III, alpha 1
chr1_-_110933683 0.561 NM_001201546
NM_001201547
NM_001201548
NM_001201549
NM_004696
SLC16A4




solute carrier family 16, member 4 (monocarboxylic acid transporter 5)




chrX_+_79675945 0.561 NM_152630
FAM46D
family with sequence similarity 46, member D
chr5_+_140602914 0.553 NM_018934
PCDHB14
protocadherin beta 14
chr12_-_14132920 0.551 NM_000834
GRIN2B
glutamate receptor, ionotropic, N-methyl D-aspartate 2B
chr6_-_89927495 0.544 NM_002042
GABRR1
gamma-aminobutyric acid (GABA) receptor, rho 1
chr10_-_116286570 0.542 ABLIM1
actin binding LIM protein 1
chr8_-_6837568 0.540 NM_004084
NM_001042500
DEFA1
DEFA1B
defensin, alpha 1
defensin, alpha 1B
chr21_-_40033617 0.540 NM_001243432
NM_001136154
NM_004449
ERG


v-ets erythroblastosis virus E26 oncogene homolog (avian)


chr8_-_93107643 0.539 RUNX1T1
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
chr21_+_38791206 0.536 NM_130436
DYRK1A
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A
chrX_-_117107700 0.533 NM_033495
NM_001168300
KLHL13

kelch-like 13 (Drosophila)

chrX_+_135230736 0.532 NM_001159700
FHL1
four and a half LIM domains 1
chr15_-_37391893 0.530 MEIS2
Meis homeobox 2
chr3_-_137851123 0.529 NM_016161
A4GNT
alpha-1,4-N-acetylglucosaminyltransferase
chr4_-_138453628 0.525 NM_019035
PCDH18
protocadherin 18
chr18_+_29769986 0.521 NM_005925
MEP1B
meprin A, beta
chr10_+_102123420 0.521


chr7_-_138458781 0.520 NM_130841
ATP6V0A4
ATPase, H+ transporting, lysosomal V0 subunit a4
chr8_-_6875777 0.520 NM_004084
NM_005217
NM_001042500
DEFA1
DEFA3
DEFA1B
defensin, alpha 1
defensin, alpha 3, neutrophil-specific
defensin, alpha 1B
chr5_+_95066628 0.520 NM_014899
RHOBTB3
Rho-related BTB domain containing 3
chr8_-_72268720 0.518 NM_172058
NM_172059
NM_172060
EYA1


eyes absent homolog 1 (Drosophila)


chr3_-_168864066 0.513 NM_001105077
NM_001163999
NM_005241
MECOM


MDS1 and EVI1 complex locus


chrX_+_66788682 0.513 NM_001011645
AR
androgen receptor
chr5_-_42811959 0.512 NM_001085486
NM_001093726
NM_005410
SEPP1


selenoprotein P, plasma, 1


chrX_+_56755666 0.512 LOC550643
uncharacterized LOC550643
chr10_-_116286661 0.500 NM_006720
ABLIM1
actin binding LIM protein 1
chr12_+_101988746 0.500 NM_002465
NM_206819
NM_206820
NM_206821
MYBPC1



myosin binding protein C, slow type



chr11_+_114167197 0.499 NNMT
nicotinamide N-methyltransferase
chr11_+_114167168 0.499 NNMT
nicotinamide N-methyltransferase
chr1_-_242612757 0.495 NM_001195811
NM_001195812
PLD5

phospholipase D family, member 5

chr18_-_53177999 0.495 NM_001243231
TCF4
transcription factor 4
chr14_-_90085325 0.495 NM_001085471
FOXN3
forkhead box N3
chr3_-_112359251 0.490 CCDC80
coiled-coil domain containing 80
chr7_-_27205123 0.487 HOXA9
homeobox A9
chr1_+_228645807 0.487 NM_175055
HIST3H2BB
histone cluster 3, H2bb
chr1_+_32043745 0.487 NM_001204415
TINAGL1
tubulointerstitial nephritis antigen-like 1
chr10_-_50732142 0.484 NM_170753
PGBD3
piggyBac transposable element derived 3
chr10_+_124320180 0.481 NM_004406
NM_007329
NM_017579
DMBT1


deleted in malignant brain tumors 1


chr10_+_5005601 0.480 AKR1C1
AKR1C3
aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase)
aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II)
chrX_-_18690187 0.478 NM_000330
RS1
retinoschisin 1
chr13_-_45010937 0.477 TSC22D1
TSC22 domain family, member 1
chr13_-_45048436 0.476 NM_001243798
TSC22D1
TSC22 domain family, member 1
chr4_-_79103271 0.473



Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.24 2.21e-04 GO:0032501 multicellular organismal process
1.31 2.90e-04 GO:0007275 multicellular organismal development
1.80 4.18e-04 GO:0009790 embryo development
1.28 6.75e-04 GO:0032502 developmental process
1.15 3.66e-03 GO:0065007 biological regulation
6.53 2.65e-02 GO:0042573 retinoic acid metabolic process
9.24 2.66e-02 GO:0009812 flavonoid metabolic process
1.37 3.02e-02 GO:0048513 organ development
4.62 3.16e-02 GO:0001523 retinoid metabolic process
4.62 3.16e-02 GO:0016101 diterpenoid metabolic process
4.95 3.96e-02 GO:0006776 vitamin A metabolic process

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
2.23 2.53e-02 GO:0016324 apical plasma membrane

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.73 4.45e-02 GO:0008289 lipid binding