Motif ID: AGCACCA

Z-value: 1.110


Mature miRNA associated with seed AGCACCA:

NamemiRBase Accession
hsa-miR-29a MIMAT0000086
hsa-miR-29b MIMAT0000100
hsa-miR-29c MIMAT0000681



Activity profile for motif AGCACCA.

activity profile for motif AGCACCA


Sorted Z-values histogram for motif AGCACCA

Sorted Z-values for motif AGCACCA



Network of associatons between targets according to the STRING database.



First level regulatory network of AGCACCA

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr7_+_94023872 3.310 NM_000089
COL1A2
collagen, type I, alpha 2
chr16_+_57406398 2.728 NM_002996
CX3CL1
chemokine (C-X3-C motif) ligand 1
chr2_-_27485774 1.776 NM_003459
SLC30A3
solute carrier family 30 (zinc transporter), member 3
chr5_-_141704575 1.661 NM_001127496
NM_030964
SPRY4

sprouty homolog 4 (Drosophila)

chr4_+_144257982 1.591 NM_002039
NM_207123
GAB1

GRB2-associated binding protein 1

chr14_+_104605059 1.518 NM_015656
KIF26A
kinesin family member 26A
chr1_-_33336289 1.442 NM_001171940
NM_153756
FNDC5

fibronectin type III domain containing 5

chr20_-_62436855 1.440 NM_025224
ZBTB46
zinc finger and BTB domain containing 46
chr1_-_33338081 1.303 NM_001171941
FNDC5
fibronectin type III domain containing 5
chr17_+_57408907 1.254 NM_001005404
YPEL2
yippee-like 2 (Drosophila)
chr19_+_39897457 1.248 NM_003407
ZFP36
zinc finger protein 36, C3H type, homolog (mouse)
chr16_-_23160509 1.240 NM_020718
USP31
ubiquitin specific peptidase 31
chr14_+_55034329 1.232 NM_001161576
NM_015589
SAMD4A

sterile alpha motif domain containing 4A

chr6_-_56112315 1.231 NM_030820
COL21A1
collagen, type XXI, alpha 1
chr2_+_234296799 1.228 NM_003648
DGKD
diacylglycerol kinase, delta 130kDa
chr5_-_43313581 1.227 NM_001098272
NM_002130
HMGCS1

3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)

chr2_+_12856813 1.198 NM_021643
TRIB2
tribbles homolog 2 (Drosophila)
chr8_-_101315457 1.181 NM_015435
RNF19A
ring finger protein 19A
chr8_-_101322245 1.175 NM_183419
RNF19A
ring finger protein 19A
chr14_+_55221505 1.175 NM_001161577
SAMD4A
sterile alpha motif domain containing 4A
chr6_-_91006580 1.160 NM_001170794
BACH2
BTB and CNC homology 1, basic leucine zipper transcription factor 2
chr2_+_234263141 1.144 NM_152879
DGKD
diacylglycerol kinase, delta 130kDa
chr9_-_10612722 1.139 NM_002839
PTPRD
protein tyrosine phosphatase, receptor type, D
chr6_-_91006460 1.081 NM_021813
BACH2
BTB and CNC homology 1, basic leucine zipper transcription factor 2
chr9_-_8733893 1.053 NM_001040712
NM_001171025
NM_130391
NM_130392
NM_130393
PTPRD




protein tyrosine phosphatase, receptor type, D




chr1_+_218518675 1.042 NM_001135599
NM_003238
TGFB2

transforming growth factor, beta 2

chr4_+_108814419 1.033 NM_001136257
NM_152621
SGMS2

sphingomyelin synthase 2

chr8_+_38585703 0.995 NM_001146216
TACC1
transforming, acidic coiled-coil containing protein 1
chr4_+_108745718 0.994 NM_001136258
SGMS2
sphingomyelin synthase 2
chr2_-_180129245 0.978 NM_178123
SESTD1
SEC14 and spectrin domains 1
chr1_-_46598250 0.951 NM_003629
NM_001114172
PIK3R3

phosphoinositide-3-kinase, regulatory subunit 3 (gamma)

chr15_-_74988342 0.925 NM_001142443
NM_001142444
NM_025083
EDC3


enhancer of mRNA decapping 3 homolog (S. cerevisiae)


chr1_-_22263676 0.916 NM_005529
HSPG2
heparan sulfate proteoglycan 2
chr1_+_185703470 0.906 NM_031935
HMCN1
hemicentin 1
chr8_+_38644721 0.895 NM_001122824
NM_006283
TACC1

transforming, acidic coiled-coil containing protein 1

chr7_+_6144504 0.884 NM_032172
USP42
ubiquitin specific peptidase 42
chr14_-_104313730 0.871 NM_015316
PPP1R13B
protein phosphatase 1, regulatory subunit 13B
chr8_+_75896707 0.853 NM_031461
CRISPLD1
cysteine-rich secretory protein LCCL domain containing 1
chr10_+_115439425 0.849 NM_001227
NM_033338
NM_033339
CASP7


caspase 7, apoptosis-related cysteine peptidase


chr1_-_17307107 0.844 NM_001135248
NM_002403
MFAP2

microfibrillar-associated protein 2

chr15_-_82338348 0.829 NM_032246
MEX3B
mex-3 homolog B (C. elegans)
chr14_+_103243813 0.812 NM_001199427
NM_003300
NM_145725
NM_145726
TRAF3



TNF receptor-associated factor 3



chr1_-_17308072 0.801 NM_001135247
NM_017459
MFAP2

microfibrillar-associated protein 2

chr2_+_42396392 0.798 NM_001145076
NM_019063
EML4

echinoderm microtubule associated protein like 4

chrX_-_112066353 0.789 NM_001113490
AMOT
angiomotin
chr7_+_155089483 0.780 NM_005542
NM_198336
NM_198337
INSIG1


insulin induced gene 1


chr2_+_189839078 0.777 NM_000090
COL3A1
collagen, type III, alpha 1
chr6_-_161694992 0.762 NM_020133
AGPAT4
1-acylglycerol-3-phosphate O-acyltransferase 4 (lysophosphatidic acid acyltransferase, delta)
chr11_+_125034558 0.755 NM_022062
PKNOX2
PBX/knotted 1 homeobox 2
chr1_-_236228476 0.750 NM_002508
NID1
nidogen 1
chr16_-_71748697 0.745 NM_015020
PHLPP2
PH domain and leucine rich repeat protein phosphatase 2
chr5_-_78282356 0.737 NM_000046
ARSB
arylsulfatase B
chr10_+_115438934 0.730 NM_033340
CASP7
caspase 7, apoptosis-related cysteine peptidase
chr1_+_211519705 0.685 NM_145759
TRAF5
TNF receptor-associated factor 5
chr6_-_110501164 0.677 NM_001024934
NM_001024935
NM_001024936
NM_003931
WASF1



WAS protein family, member 1



chr7_+_116140097 0.673 NM_001206748
CAV2
caveolin 2
chr20_+_33292117 0.671 NM_021202
TP53INP2
tumor protein p53 inducible nuclear protein 2
chr12_-_121734543 0.670 NM_172226
CAMKK2
calcium/calmodulin-dependent protein kinase kinase 2, beta
chr5_+_74632992 0.667 NM_000859
NM_001130996
HMGCR

3-hydroxy-3-methylglutaryl-CoA reductase

chr11_-_118781612 0.666 NM_182557
BCL9L
B-cell CLL/lymphoma 9-like
chr1_+_211500147 0.663 NM_001033910
TRAF5
TNF receptor-associated factor 5
chr15_-_71055745 0.660 NM_018003
UACA
uveal autoantigen with coiled-coil domains and ankyrin repeats
chr1_-_161102457 0.658 NM_001039711
NM_032998
DEDD

death effector domain containing

chr5_+_66124603 0.648 NM_015183
MAST4
microtubule associated serine/threonine kinase family member 4
chr1_-_161102210 0.646 NM_001039712
DEDD
death effector domain containing
chr17_+_26662547 0.645 NM_021137
TNFAIP1
tumor necrosis factor, alpha-induced protein 1 (endothelial)
chr14_-_65438794 0.644 NM_198686
RAB15
RAB15, member RAS onocogene family
chr12_+_3186520 0.640 NM_001168320
NM_006675
TSPAN9

tetraspanin 9

chr6_+_106959729 0.629 NM_001624
AIM1
absent in melanoma 1
chr2_-_25474948 0.626 NM_153759
DNMT3A
DNA (cytosine-5-)-methyltransferase 3 alpha
chr11_+_33563772 0.625 NM_012194
C11orf41
chromosome 11 open reading frame 41
chr7_+_28475233 0.623 NM_004904
CREB5
cAMP responsive element binding protein 5
chr1_-_3528058 0.605 NM_001409
MEGF6
multiple EGF-like-domains 6
chr7_+_28452143 0.605 NM_182898
CREB5
cAMP responsive element binding protein 5
chr14_-_76448091 0.604 NM_003239
TGFB3
transforming growth factor, beta 3
chr2_-_208634051 0.604 NM_003468
FZD5
frizzled family receptor 5
chr7_+_116139619 0.596 NM_001206747
NM_001233
NM_198212
CAV2


caveolin 2


chr1_-_32860014 0.587 NM_001143888
NM_001143889
NM_001143890
NM_018045
BSDC1



BSD domain containing 1



chr15_-_40398573 0.587 NM_033503
BMF
Bcl2 modifying factor
chr16_+_2732475 0.585 NM_018992
KCTD5
potassium channel tetramerisation domain containing 5
chr4_-_76944585 0.585 NM_001565
CXCL10
chemokine (C-X-C motif) ligand 10
chr1_-_249120063 0.580 NM_030645
SH3BP5L
SH3-binding domain protein 5-like
chr14_+_23067128 0.579 NM_022060
ABHD4
abhydrolase domain containing 4
chr16_+_4382224 0.575 NM_032575
GLIS2
GLIS family zinc finger 2
chr1_+_32666201 0.575 NM_024296
CCDC28B
coiled-coil domain containing 28B
chr1_+_110009099 0.572 NM_001040709
SYPL2
synaptophysin-like 2
chrX_+_107683015 0.558 NM_000495
NM_033380
COL4A5

collagen, type IV, alpha 5

chr21_-_19191643 0.558 NM_001100420
NM_001100421
NM_017447
C21orf91


chromosome 21 open reading frame 91


chr9_-_37465384 0.556 NM_014872
ZBTB5
zinc finger and BTB domain containing 5
chr7_+_28725597 0.555 NM_001011666
CREB5
cAMP responsive element binding protein 5
chr1_-_86622107 0.543 NM_152890
COL24A1
collagen, type XXIV, alpha 1
chr7_+_28338939 0.539 NM_182899
CREB5
cAMP responsive element binding protein 5
chr9_+_129622935 0.533 NM_001099270
ZBTB34
zinc finger and BTB domain containing 34
chr13_-_110959441 0.532 NM_001845
COL4A1
collagen, type IV, alpha 1
chr15_-_40398286 0.532 NM_001003942
NM_001003943
BMF

Bcl2 modifying factor

chr8_-_81787015 0.529 NM_001033723
ZNF704
zinc finger protein 704
chr1_-_41628688 0.528 NM_001172221
SCMH1
sex comb on midleg homolog 1 (Drosophila)
chr14_+_77228132 0.525 NM_014909
VASH1
vasohibin 1
chr2_-_164592512 0.524 NM_018086
FIGN
fidgetin
chr2_-_25564745 0.524 NM_022552
DNMT3A
DNA (cytosine-5-)-methyltransferase 3 alpha
chr10_-_29923900 0.523 NM_021738
SVIL
supervillin
chr15_-_70994608 0.519 NM_001008224
UACA
uveal autoantigen with coiled-coil domains and ankyrin repeats
chr3_+_182970853 0.515 NM_032047
B3GNT5
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5
chr7_-_75368276 0.514 NM_001243198
NM_005338
HIP1

huntingtin interacting protein 1

chr1_+_203595897 0.514 NM_001001396
NM_001684
ATP2B4

ATPase, Ca++ transporting, plasma membrane 4

chr5_-_111093030 0.512 NM_001142482
NM_001142481
C5orf13

chromosome 5 open reading frame 13

chr1_-_202777545 0.508 NM_006618
KDM5B
lysine (K)-specific demethylase 5B
chr7_-_25164902 0.506 NM_018947
CYCS
cytochrome c, somatic
chr19_-_1021122 0.503 NM_001033026
NM_033420
C19orf6

chromosome 19 open reading frame 6

chr12_-_51477299 0.497 NM_030809
CSRNP2
cysteine-serine-rich nuclear protein 2
chr3_+_72937168 0.494 NM_001080393
GXYLT2
glucoside xylosyltransferase 2
chr17_-_55980749 0.494 NM_017949
CUEDC1
CUE domain containing 1
chr11_+_66188474 0.492 NM_178864
NPAS4
neuronal PAS domain protein 4
chr15_-_77712436 0.491 NM_024776
PEAK1
NKF3 kinase family member
chr5_-_121412805 0.488 NM_001178102
LOX
lysyl oxidase
chr15_-_40401041 0.487 NM_001003940
BMF
Bcl2 modifying factor
chr14_-_45431121 0.485 NM_017658
KLHL28
kelch-like 28 (Drosophila)
chr16_-_1429612 0.484 NM_001193389
NM_023076
UNKL

unkempt homolog (Drosophila)-like

chr5_-_121414011 0.483 NM_002317
LOX
lysyl oxidase
chr4_+_52709165 0.483 NM_001040402
NM_015115
DCUN1D4

DCN1, defective in cullin neddylation 1, domain containing 4 (S. cerevisiae)

chr7_-_25019625 0.481 NM_015550
NM_145320
NM_145321
NM_145322
OSBPL3



oxysterol binding protein-like 3



chr20_+_35201854 0.480 NM_001199513
NM_001199514
TGIF2

TGFB-induced factor homeobox 2

chr1_-_9970265 0.480 NM_001012329
NM_020248
CTNNBIP1

catenin, beta interacting protein 1

chr1_-_41707792 0.476 NM_001172218
NM_001172219
NM_001172220
NM_012236
SCMH1



sex comb on midleg homolog 1 (Drosophila)



chr5_-_111093251 0.471 NM_001142479
NM_001142480
NM_001142478
C5orf13


chromosome 5 open reading frame 13


chr2_-_220083699 0.470 NM_005689
ABCB6
ATP-binding cassette, sub-family B (MDR/TAP), member 6
chr5_-_111092918 0.468 NM_004772
C5orf13
chromosome 5 open reading frame 13
chr12_-_121736110 0.467 NM_006549
NM_153499
NM_153500
NM_172214
NM_172215
NM_172216
CAMKK2





calcium/calmodulin-dependent protein kinase kinase 2, beta





chr1_+_203274646 0.467 NM_006763
BTG2
BTG family, member 2
chr5_-_111091947 0.466 NM_001142483
C5orf13
chromosome 5 open reading frame 13
chr7_+_130126035 0.465 NM_177524
MEST
mesoderm specific transcript homolog (mouse)
chr7_-_28220342 0.463 NM_175061
JAZF1
JAZF zinc finger 1
chr13_+_110959592 0.462 NM_001846
COL4A2
collagen, type IV, alpha 2
chr1_-_41625539 0.457 NM_001172222
SCMH1
sex comb on midleg homolog 1 (Drosophila)
chr12_+_104359557 0.452 NM_003211
TDG
thymine-DNA glycosylase
chr20_+_35201948 0.447 NM_021809
TGIF2
TGFB-induced factor homeobox 2
chr10_-_105614952 0.446 NM_014631
SH3PXD2A
SH3 and PX domains 2A
chr1_+_46049659 0.442 NM_001195193
NM_002482
NM_152298
NASP


nuclear autoantigenic sperm protein (histone-binding)


chr15_-_48937795 0.441 NM_000138
FBN1
fibrillin 1
chr3_-_149421059 0.441 NM_001168278
WWTR1
WW domain containing transcription regulator 1
chr5_-_122372413 0.438 NM_000943
PPIC
peptidylprolyl isomerase C (cyclophilin C)
chrX_-_112084006 0.434 NM_133265
AMOT
angiomotin
chr1_+_61542928 0.432 NM_001145511
NFIA
nuclear factor I/A
chr2_+_74273449 0.431 NM_144993
TET3
tet methylcytosine dioxygenase 3
chr17_-_35656691 0.427 NM_198837
NM_198838
ACACA

acetyl-CoA carboxylase alpha

chr1_-_41627045 0.427 NM_001031694
SCMH1
sex comb on midleg homolog 1 (Drosophila)
chr17_-_27621163 0.425 NM_020772
NUFIP2
nuclear fragile X mental retardation protein interacting protein 2
chr17_-_35766762 0.424 NM_198834
NM_198839
ACACA

acetyl-CoA carboxylase alpha

chr5_-_111093792 0.420 NM_001142477
NM_001142476
C5orf13

chromosome 5 open reading frame 13

chr3_-_149375584 0.419 NM_001168280
NM_015472
WWTR1

WW domain containing transcription regulator 1

chr5_-_137368778 0.419 NM_001101800
NM_001101801
NM_016603
FAM13B


family with sequence similarity 13, member B


chr10_-_30024594 0.416 NM_003174
SVIL
supervillin
chr5_+_112312392 0.411 NM_001242377
NM_152624
DCP2

DCP2 decapping enzyme homolog (S. cerevisiae)

chr7_+_130131921 0.404 NM_002402
MEST
mesoderm specific transcript homolog (mouse)
chr3_+_186288445 0.402 NM_016306
DNAJB11
DnaJ (Hsp40) homolog, subfamily B, member 11
chr7_+_130131172 0.400 NM_177525
MEST
mesoderm specific transcript homolog (mouse)
chr5_-_111312522 0.398 NM_001142474
NM_001142475
C5orf13

chromosome 5 open reading frame 13

chr2_+_159825083 0.395 NM_001145909
NM_033394
TANC1

tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1

chr6_+_138188352 0.394 NM_006290
TNFAIP3
tumor necrosis factor, alpha-induced protein 3
chr11_-_60928878 0.394 NM_017966
VPS37C
vacuolar protein sorting 37 homolog C (S. cerevisiae)
chr19_-_44100127 0.392 NM_001007561
IRGQ
immunity-related GTPase family, Q
chr11_+_842821 0.392 NM_001025238
NM_001025239
NM_003271
NM_001025235
NM_001025236
TSPAN4




tetraspanin 4




chr8_-_37756971 0.388 NM_001002814
NM_025151
RAB11FIP1

RAB11 family interacting protein 1 (class I)

chr2_-_204399906 0.387 NM_203365
NM_213589
RAPH1

Ras association (RalGDS/AF-6) and pleckstrin homology domains 1

chr8_-_33424642 0.385 NM_024787
RNF122
ring finger protein 122
chr15_+_42066631 0.385 NM_001128608
NM_014994
MAPKBP1

mitogen-activated protein kinase binding protein 1

chr17_-_35716024 0.384 NM_198836
ACACA
acetyl-CoA carboxylase alpha
chr16_+_3493605 0.383 NM_001083601
NAA60
N(alpha)-acetyltransferase 60, NatF catalytic subunit
chr10_-_43904306 0.381 NM_001098205
HNRNPF
heterogeneous nuclear ribonucleoprotein F
chr19_-_913224 0.381 NM_138774
R3HDM4
R3H domain containing 4
chr11_-_18655962 0.380 NM_194285
SPTY2D1
SPT2, Suppressor of Ty, domain containing 1 (S. cerevisiae)
chr5_-_151066492 0.379 NM_003118
SPARC
secreted protein, acidic, cysteine-rich (osteonectin)
chr16_+_75032874 0.375 NM_032268
ZNRF1
zinc and ring finger 1
chr10_-_735522 0.374 NM_014974
DIP2C
DIP2 disco-interacting protein 2 homolog C (Drosophila)
chr10_-_43904598 0.374 NM_004966
NM_001098204
HNRNPF

heterogeneous nuclear ribonucleoprotein F

chr10_+_104503724 0.372 NM_001083913
C10orf26
chromosome 10 open reading frame 26
chr11_+_844445 0.372 NM_001025237
TSPAN4
tetraspanin 4
chr5_-_174871162 0.371 NM_000794
DRD1
dopamine receptor D1
chr11_+_75273100 0.369 NM_001207014
NM_001235
SERPINH1

serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)

chr16_-_10674443 0.368 NM_001424
EMP2
epithelial membrane protein 2
chr10_+_124145584 0.368 NM_001195608
PLEKHA1
pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1
chr6_-_52860076 0.366 NM_001512
GSTA4
glutathione S-transferase alpha 4
chr3_-_125239049 0.362 NM_003794
SNX4
sorting nexin 4
chr2_-_197791339 0.360 NM_024989
PGAP1
post-GPI attachment to proteins 1
chr2_-_228029274 0.356 NM_000092
COL4A4
collagen, type IV, alpha 4
chr22_-_44893903 0.356 NM_032287
LDOC1L
leucine zipper, down-regulated in cancer 1-like
chr1_+_61547388 0.355 NM_001145512
NFIA
nuclear factor I/A
chr2_+_220144024 0.355 NM_001039550
NM_006736
DNAJB2

DnaJ (Hsp40) homolog, subfamily B, member 2

chr17_-_63052884 0.354 NM_006572
GNA13
guanine nucleotide binding protein (G protein), alpha 13
chr2_-_1748285 0.354 NM_012293
PXDN
peroxidasin homolog (Drosophila)
chr11_+_844062 0.352 NM_001025234
TSPAN4
tetraspanin 4
chr6_+_108882068 0.351 NM_001455
FOXO3
forkhead box O3
chr15_-_64648359 0.349 NM_022048
CSNK1G1
casein kinase 1, gamma 1
chr16_+_69220940 0.349 NM_006750
SNTB2
syntrophin, beta 2 (dystrophin-associated protein A1, 59kDa, basic component 2)
chr3_-_120169493 0.349 NM_007085
FSTL1
follistatin-like 1
chr6_-_16761600 0.348 NM_000332
NM_001128164
ATXN1

ataxin 1

chr6_-_88854989 0.347 NM_033181
CNR1
cannabinoid receptor 1 (brain)
chr16_+_3507956 0.347 NM_001083600
NM_024845
NAA60

N(alpha)-acetyltransferase 60, NatF catalytic subunit

chr16_+_71879893 0.346 NM_001137675
ATXN1L
ataxin 1-like
chr8_+_11141983 0.345 NM_015458
MTMR9
myotubularin related protein 9

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
9.95 2.59e-04 GO:0030199 collagen fibril organization
4.76 9.82e-04 GO:0030198 extracellular matrix organization
1.40 3.90e-03 GO:0032502 developmental process
1.43 4.55e-03 GO:0007275 multicellular organismal development
1.44 2.61e-02 GO:0048731 system development
19.89 3.29e-02 GO:0034391 regulation of smooth muscle cell apoptosis

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
12.43 5.38e-11 GO:0005581 collagen
6.34 1.02e-10 GO:0044420 extracellular matrix part
3.32 2.83e-07 GO:0005578 proteinaceous extracellular matrix
2.98 1.71e-06 GO:0031012 extracellular matrix
6.40 2.42e-06 GO:0005604 basement membrane
24.86 6.79e-05 GO:0005587 collagen type IV
4.97 2.04e-04 GO:0030027 lamellipodium
21.31 2.31e-04 GO:0030935 sheet-forming collagen
3.34 7.37e-04 GO:0031252 cell leading edge
13.56 4.54e-03 GO:0005583 fibrillar collagen

Gene overrepresentation in function category:

enrichment   p-value GO term description
5.97 2.90e-06 GO:0005201 extracellular matrix structural constituent
18.99 4.95e-06 GO:0048407 platelet-derived growth factor binding
1.27 4.37e-05 GO:0005515 protein binding
1.11 3.79e-02 GO:0005488 binding