Motif ID: AHR_ARNT_ARNT2.p2

Z-value: 1.012


Transcription factors associated with AHR_ARNT_ARNT2.p2:

Gene SymbolEntrez IDGene Name
AHR 196 aryl hydrocarbon receptor
ARNT 405 aryl hydrocarbon receptor nuclear translocator
ARNT2 9915 aryl-hydrocarbon receptor nuclear translocator 2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.p-valuePlot
ARNTchr1_-_1508490620.395.3e-02Click!
AHRchr7_+_17338182-0.096.7e-01Click!
ARNT2chr15_+_80696569-0.086.9e-01Click!


Activity profile for motif AHR_ARNT_ARNT2.p2.

activity profile for motif AHR_ARNT_ARNT2.p2


Sorted Z-values histogram for motif AHR_ARNT_ARNT2.p2

Sorted Z-values for motif AHR_ARNT_ARNT2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of AHR_ARNT_ARNT2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr5_+_151151483 1.362 G3BP1
GTPase activating protein (SH3 domain) binding protein 1
chr19_+_17666381 0.990 GLT25D1
glycosyltransferase 25 domain containing 1
chr4_+_94750041 0.956 NM_005172
ATOH1
atonal homolog 1 (Drosophila)
chr5_+_151151516 0.955 G3BP1
GTPase activating protein (SH3 domain) binding protein 1
chr12_-_88974094 0.920 NM_000899
NM_003994
KITLG

KIT ligand

chr1_-_205290756 0.895 NM_030952
NUAK2
NUAK family, SNF1-like kinase, 2
chr5_+_151151511 0.865 G3BP1
GTPase activating protein (SH3 domain) binding protein 1
chr15_+_84115979 0.815 NM_003027
SH3GL3
SH3-domain GRB2-like 3
chr5_+_151151514 0.800 G3BP1
GTPase activating protein (SH3 domain) binding protein 1
chr6_+_43738757 0.798 VEGFA
vascular endothelial growth factor A
chr5_+_151151462 0.751 NM_005754
NM_198395
G3BP1

GTPase activating protein (SH3 domain) binding protein 1

chr20_-_10654429 0.734 NM_000214
JAG1
jagged 1
chr20_-_10654139 0.710 JAG1
jagged 1
chr8_-_80679897 0.709 NM_001040708
NM_012258
HEY1

hairy/enhancer-of-split related with YRPW motif 1

chr1_+_221053000 0.678 HLX
H2.0-like homeobox
chr2_+_219433517 0.626 NM_005444
RQCD1
RCD1 required for cell differentiation1 homolog (S. pombe)
chr9_-_34590137 0.603 NM_001207011
CNTFR
ciliary neurotrophic factor receptor
chr15_-_79382839 0.575 RASGRF1
Ras protein-specific guanine nucleotide-releasing factor 1
chr16_+_30709913 0.552


chr10_-_105452878 0.548 SH3PXD2A
SH3 and PX domains 2A
chr9_-_34589679 0.538 NM_001842
NM_147164
CNTFR

ciliary neurotrophic factor receptor

chr5_-_172755418 0.529 STC2
stanniocalcin 2
chr2_+_219433302 0.528 RQCD1
RCD1 required for cell differentiation1 homolog (S. pombe)
chr4_+_38665587 0.527 NM_016531
KLF3
Kruppel-like factor 3 (basic)
chr4_-_76598558 0.512 G3BP2
GTPase activating protein (SH3 domain) binding protein 2
chr15_+_84116172 0.502 SH3GL3
SH3-domain GRB2-like 3
chr6_+_138188352 0.490 NM_006290
TNFAIP3
tumor necrosis factor, alpha-induced protein 3
chr5_-_172755195 0.489 STC2
stanniocalcin 2
chr4_-_25032306 0.465 NM_018176
LGI2
leucine-rich repeat LGI family, member 2
chr14_-_21852085 0.462 SUPT16H
suppressor of Ty 16 homolog (S. cerevisiae)
chr19_-_14201230 0.460 NM_138352
SAMD1
sterile alpha motif domain containing 1
chr22_+_20105068 0.443 RANBP1
RAN binding protein 1
chr14_+_60975937 0.439 NM_007374
SIX6
SIX homeobox 6
chr12_+_103351451 0.431 NM_004316
ASCL1
achaete-scute complex homolog 1 (Drosophila)
chr15_+_52311432 0.423 MAPK6
mitogen-activated protein kinase 6
chr5_+_56111379 0.420 MAP3K1
mitogen-activated protein kinase kinase kinase 1
chr15_+_67358194 0.414 NM_005902
SMAD3
SMAD family member 3
chr16_+_27214806 0.412 NM_024773
JMJD5
jumonji domain containing 5
chr5_+_151151660 0.405 G3BP1
GTPase activating protein (SH3 domain) binding protein 1
chr3_-_160822625 0.404 NM_033169
NM_001038628
NM_003781
NM_033167
NM_033168
B3GALNT1




beta-1,3-N-acetylgalactosaminyltransferase 1 (globoside blood group)




chr6_-_38607589 0.395 BTBD9
BTB (POZ) domain containing 9
chr19_+_17666502 0.385 NM_024656
GLT25D1
glycosyltransferase 25 domain containing 1
chr22_+_20105076 0.380 RANBP1
RAN binding protein 1
chr7_+_28448970 0.377 LOC401317
uncharacterized LOC401317
chr20_-_1373702 0.370 FKBP1A-SDCBP2
FKBP1A
FKBP1A-SDCBP2 readthrough (non-protein coding)
FK506 binding protein 1A, 12kDa
chr14_-_21852161 0.362 SUPT16H
suppressor of Ty 16 homolog (S. cerevisiae)
chr4_-_185747051 0.358 ACSL1
acyl-CoA synthetase long-chain family member 1
chr8_+_126442557 0.357 NM_025195
TRIB1
tribbles homolog 1 (Drosophila)
chr21_-_35987144 0.355 NM_004414
RCAN1
regulator of calcineurin 1
chr3_+_105085740 0.354 ALCAM
activated leukocyte cell adhesion molecule
chr19_+_45971249 0.350 NM_001114171
NM_006732
FOSB

FBJ murine osteosarcoma viral oncogene homolog B

chr16_-_86542463 0.349 LOC400550
uncharacterized LOC400550
chr4_+_81118639 0.344 NM_001099403
PRDM8
PR domain containing 8
chr15_+_67358161 0.344 SMAD3
SMAD family member 3
chr20_-_1373744 0.340 NM_000801
NM_001199786
NM_054014
FKBP1A


FK506 binding protein 1A, 12kDa


chr15_+_52311408 0.338 NM_002748
MAPK6
mitogen-activated protein kinase 6
chr5_-_141704575 0.337 NM_001127496
NM_030964
SPRY4

sprouty homolog 4 (Drosophila)

chr2_+_203500211 0.333 FAM117B
family with sequence similarity 117, member B
chr7_-_91763677 0.333 CYP51A1
cytochrome P450, family 51, subfamily A, polypeptide 1
chr4_-_76598563 0.332 G3BP2
GTPase activating protein (SH3 domain) binding protein 2
chr19_-_46088074 0.331 OPA3
optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia)
chr17_-_40075153 0.329 ACLY
ATP citrate lyase
chr11_-_615649 0.325 NM_004031
IRF7
interferon regulatory factor 7
chr6_-_6007632 0.322 NM_016588
NRN1
neuritin 1
chr6_-_30585024 0.322 PPP1R10
protein phosphatase 1, regulatory subunit 10
chr19_+_1753661 0.321 NM_001080488
ONECUT3
one cut homeobox 3
chr22_+_20105145 0.321 RANBP1
RAN binding protein 1
chr17_-_56084611 0.320 SRSF1
serine/arginine-rich splicing factor 1
chr22_+_20105095 0.320 RANBP1
RAN binding protein 1
chr12_-_111021026 0.316 NM_139283
PPTC7
PTC7 protein phosphatase homolog (S. cerevisiae)
chr8_+_90770201 0.316 RIPK2
receptor-interacting serine-threonine kinase 2
chr19_+_10381516 0.316 NM_000201
ICAM1
intercellular adhesion molecule 1
chr4_-_90032548 0.316 FAM13A
family with sequence similarity 13, member A
chr3_-_127541975 0.316 NM_001003794
MGLL
monoglyceride lipase
chr15_+_52311438 0.313 MAPK6
mitogen-activated protein kinase 6
chr11_-_18813127 0.313 NM_001039970
NM_006906
NM_032781
PTPN5


protein tyrosine phosphatase, non-receptor type 5 (striatum-enriched)


chr2_+_106682111 0.311 NM_032411
C2orf40
chromosome 2 open reading frame 40
chrX_+_129305553 0.307 NM_004794
RAB33A
RAB33A, member RAS oncogene family
chr11_+_369723 0.306 NM_178537
B4GALNT4
beta-1,4-N-acetyl-galactosaminyl transferase 4
chr17_-_8059637 0.305 PER1
period homolog 1 (Drosophila)
chr17_-_40075229 0.303 ACLY
ATP citrate lyase
chr20_-_1373571 0.303 FKBP1A
FK506 binding protein 1A, 12kDa
chr22_-_19511777 0.302 CLDN5
claudin 5
chr11_-_441956 0.301 ANO9
anoctamin 9
chr6_-_154831652 0.300 CNKSR3
CNKSR family member 3
chr5_-_88179278 0.299 NM_001193350
NM_002397
MEF2C

myocyte enhancer factor 2C

chr19_+_17666457 0.297 GLT25D1
glycosyltransferase 25 domain containing 1
chr8_-_48650683 0.297 CEBPD
CCAAT/enhancer binding protein (C/EBP), delta
chr6_-_154831704 0.296 NM_173515
CNKSR3
CNKSR family member 3
chr3_+_151986731 0.296 MBNL1
muscleblind-like (Drosophila)
chr17_+_7210841 0.291 NM_001970
EIF5A
eukaryotic translation initiation factor 5A
chr2_+_85766291 0.290 MAT2A
methionine adenosyltransferase II, alpha
chr3_-_49449400 0.290 RHOA
ras homolog gene family, member A
chr6_-_154831788 0.286 CNKSR3
CNKSR family member 3
chr18_+_55102777 0.285 NM_004852
ONECUT2
one cut homeobox 2
chr3_-_49449393 0.285 RHOA
ras homolog gene family, member A
chr6_-_48036385 0.283 NM_001013732
NM_207499
C6orf138

chromosome 6 open reading frame 138

chr8_+_90769974 0.282 NM_003821
RIPK2
receptor-interacting serine-threonine kinase 2
chr21_-_38639593 0.282 DSCR3
Down syndrome critical region gene 3
chr13_-_44361032 0.282 NM_001242863
NM_017993
ENOX1

ecto-NOX disulfide-thiol exchanger 1

chr2_+_135676409 0.281 CCNT2
cyclin T2
chr6_-_136610894 0.280 BCLAF1
BCL2-associated transcription factor 1
chrX_-_128788913 0.278 NM_017413
APLN
apelin
chr11_-_441995 0.278 NM_001012302
ANO9
anoctamin 9
chr9_+_127020586 0.278


chr15_-_79383080 0.278 NM_001145648
NM_002891
RASGRF1

Ras protein-specific guanine nucleotide-releasing factor 1

chr19_+_47524142 0.278 NM_002517
NPAS1
neuronal PAS domain protein 1
chr1_+_218519576 0.278 TGFB2
transforming growth factor, beta 2
chr3_-_49449525 0.277 NM_001664
RHOA
ras homolog gene family, member A
chr5_-_88178964 0.275 MEF2C
myocyte enhancer factor 2C
chr7_-_91763775 0.275 CYP51A1
cytochrome P450, family 51, subfamily A, polypeptide 1
chr13_-_38443859 0.274 NM_001135955
NM_001135956
NM_001135957
NM_001135958
NM_003306
NM_016179
TRPC4





transient receptor potential cation channel, subfamily C, member 4





chr10_+_12391708 0.274 CAMK1D
calcium/calmodulin-dependent protein kinase ID
chr19_-_39340362 0.274 HNRNPL
heterogeneous nuclear ribonucleoprotein L
chr3_-_49449357 0.273 RHOA
ras homolog gene family, member A
chr2_+_61108724 0.272 NM_002908
REL
v-rel reticuloendotheliosis viral oncogene homolog (avian)
chr2_+_61108702 0.271 REL
v-rel reticuloendotheliosis viral oncogene homolog (avian)
chr17_+_79679399 0.269 SLC25A10
solute carrier family 25 (mitochondrial carrier; dicarboxylate transporter), member 10
chr22_-_19512001 0.266 CLDN5
claudin 5
chr11_+_61447816 0.266 NM_006133
DAGLA
diacylglycerol lipase, alpha
chr17_-_62658311 0.266 NM_022739
SMURF2
SMAD specific E3 ubiquitin protein ligase 2
chr3_-_49449423 0.266 RHOA
ras homolog gene family, member A
chr6_-_43543767 0.264 NM_020750
XPO5
exportin 5
chr3_-_49449409 0.263 RHOA
ras homolog gene family, member A
chr22_+_42229105 0.262 NM_004599
SREBF2
sterol regulatory element binding transcription factor 2
chr8_+_42752142 0.262 HOOK3
hook homolog 3 (Drosophila)
chr15_-_72410108 0.261 MYO9A
myosin IXA
chr6_-_30585016 0.260 NM_002714
PPP1R10
protein phosphatase 1, regulatory subunit 10
chr9_+_4985082 0.260 JAK2
Janus kinase 2
chr2_+_61108775 0.258 REL
v-rel reticuloendotheliosis viral oncogene homolog (avian)
chr14_-_24780570 0.258 NM_014430
CIDEB
cell death-inducing DFFA-like effector b
chr14_-_74226890 0.256 NM_194278
C14orf43
chromosome 14 open reading frame 43
chr22_-_42017032 0.256 NM_015704
PPPDE2
PPPDE peptidase domain containing 2
chr14_-_24780626 0.256


chr14_-_65569056 0.256 MAX
MYC associated factor X
chr5_-_172756505 0.255 NM_003714
STC2
stanniocalcin 2
chr11_+_112832281 0.255 NCAM1
neural cell adhesion molecule 1
chr16_+_28834372 0.254 ATXN2L
ataxin 2-like
chr5_-_88199868 0.254 NM_001131005
NM_001193347
MEF2C

myocyte enhancer factor 2C

chr6_+_14117857 0.253 NM_001040280
NM_004233
CD83

CD83 molecule

chr14_-_24780641 0.251 CIDEB
cell death-inducing DFFA-like effector b
chr2_+_73441344 0.247 NM_006062
SMYD5
SMYD family member 5
chr17_+_7210929 0.245 EIF5A
eukaryotic translation initiation factor 5A
chr17_+_72667255 0.245 NM_175738
RAB37
RAB37, member RAS oncogene family
chr12_+_57482886 0.244 NAB2
NGFI-A binding protein 2 (EGR1 binding protein 2)
chr16_+_28834407 0.242 NM_007245
NM_145714
NM_148414
NM_148415
NM_148416
ATXN2L




ataxin 2-like




chr17_-_40075238 0.241 NM_001096
NM_198830
ACLY

ATP citrate lyase

chrX_-_9733916 0.241 NM_000273
GPR143
G protein-coupled receptor 143
chr22_+_42229137 0.240 SREBF2
sterol regulatory element binding transcription factor 2
chr5_+_176560882 0.240 NSD1
nuclear receptor binding SET domain protein 1
chr14_-_94254765 0.238 NM_178013
PRIMA1
proline rich membrane anchor 1
chr6_-_43543600 0.238 XPO5
exportin 5
chr12_-_46662533 0.237 SLC38A1
solute carrier family 38, member 1
chr1_+_2518071 0.237 NM_001195736
NM_001195737
NM_001195738
NM_001195740
NM_001195741
NM_152371
FAM213B





family with sequence similarity 213, member B





chr11_-_207324 0.237 BET1L
blocked early in transport 1 homolog (S. cerevisiae)-like
chr7_-_156802553 0.237 MNX1
motor neuron and pancreas homeobox 1
chr3_+_73046081 0.237 NM_174907
PPP4R2
protein phosphatase 4, regulatory subunit 2
chr16_+_31191461 0.236 FUS
fused in sarcoma
chr12_+_64798050 0.236 NM_007235
XPOT
exportin, tRNA (nuclear export receptor for tRNAs)
chr3_+_73045939 0.236 PPP4R2
protein phosphatase 4, regulatory subunit 2
chr15_-_72410226 0.233 NM_006901
MYO9A
myosin IXA
chr22_-_42016842 0.233 PPPDE2
PPPDE peptidase domain containing 2
chrX_-_18372777 0.232 NM_006089
SCML2
sex comb on midleg-like 2 (Drosophila)
chr3_+_14444083 0.232 NM_001134367
NM_001134368
NM_003043
SLC6A6


solute carrier family 6 (neurotransmitter transporter, taurine), member 6


chr15_-_40213087 0.229 NM_007223
GPR176
G protein-coupled receptor 176
chr8_+_126010719 0.228 NM_003129
SQLE
squalene epoxidase
chr17_-_40075190 0.226 ACLY
ATP citrate lyase
chr1_-_47184790 0.225


chr20_-_20693122 0.225 NM_020343
RALGAPA2
Ral GTPase activating protein, alpha subunit 2 (catalytic)
chr19_-_56632644 0.224 NM_001002836
ZNF787
zinc finger protein 787
chr1_+_2518464 0.224 FAM213B
family with sequence similarity 213, member B
chr2_+_10183630 0.224 NM_003597
NM_001177716
KLF11

Kruppel-like factor 11

chr11_-_59436366 0.221 PATL1
protein associated with topoisomerase II homolog 1 (yeast)
chr4_-_54930771 0.220 NM_012110
CHIC2
cysteine-rich hydrophobic domain 2
chr22_+_20104810 0.219 NM_002882
RANBP1
RAN binding protein 1
chr4_-_103748649 0.219 NM_181887
NM_181891
UBE2D3

ubiquitin-conjugating enzyme E2D 3

chr8_+_126010748 0.218 SQLE
squalene epoxidase
chr5_-_179050635 0.218 HNRNPH1
heterogeneous nuclear ribonucleoprotein H1 (H)
chr12_-_111021122 0.218 PPTC7
PTC7 protein phosphatase homolog (S. cerevisiae)
chr17_+_18087091 0.218 ALKBH5
alkB, alkylation repair homolog 5 (E. coli)
chr3_+_67048726 0.217 NM_032505
KBTBD8
kelch repeat and BTB (POZ) domain containing 8
chr4_-_149363498 0.217 NM_000901
NM_001166104
NR3C2

nuclear receptor subfamily 3, group C, member 2

chr7_+_98246595 0.217 NM_002523
NPTX2
neuronal pentraxin II
chr10_+_99258615 0.216 NM_024954
UBTD1
ubiquitin domain containing 1
chr7_-_92462637 0.216 CDK6
cyclin-dependent kinase 6
chr1_-_16482426 0.215 NM_004431
EPHA2
EPH receptor A2
chr19_-_39340609 0.214 NM_001533
HNRNPL
heterogeneous nuclear ribonucleoprotein L
chr5_+_127419407 0.213 NM_001046
SLC12A2
solute carrier family 12 (sodium/potassium/chloride transporters), member 2
chr6_-_10412606 0.212 NM_001032280
TFAP2A
transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
chr10_+_94449678 0.212 NM_002729
HHEX
hematopoietically expressed homeobox
chr3_-_160283071 0.211 KPNA4
karyopherin alpha 4 (importin alpha 3)
chr15_-_75743776 0.211 NM_015477
SIN3A
SIN3 transcription regulator homolog A (yeast)
chr16_+_30710461 0.211 NM_006662
SRCAP
Snf2-related CREBBP activator protein
chr14_+_74035865 0.210 ACOT2
acyl-CoA thioesterase 2
chr8_-_26371387 0.210 NM_007257
PNMA2
paraneoplastic antigen MA2
chr3_-_75834661 0.209 ZNF717
zinc finger protein 717
chr12_+_4382882 0.208 NM_001759
CCND2
cyclin D2
chr12_+_83080621 0.208 TMTC2
transmembrane and tetratricopeptide repeat containing 2
chr7_-_105925410 0.207 NM_005746
NAMPT
nicotinamide phosphoribosyltransferase
chr19_+_12902295 0.207 NM_002229
JUNB
jun B proto-oncogene

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.16 5.94e-23 GO:0009987 cellular process
1.25 2.77e-15 GO:0044237 cellular metabolic process
1.32 4.83e-15 GO:0044260 cellular macromolecule metabolic process
1.23 5.00e-13 GO:0044238 primary metabolic process
1.41 9.80e-13 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.35 7.30e-12 GO:0016043 cellular component organization
1.34 1.57e-11 GO:0071840 cellular component organization or biogenesis
1.48 9.25e-11 GO:0010467 gene expression
1.19 9.44e-11 GO:0008152 metabolic process
1.39 1.67e-10 GO:0071842 cellular component organization at cellular level
1.25 1.69e-10 GO:0043170 macromolecule metabolic process
1.34 1.79e-10 GO:0034641 cellular nitrogen compound metabolic process
1.37 2.74e-10 GO:0071841 cellular component organization or biogenesis at cellular level
1.18 2.95e-10 GO:0065007 biological regulation
1.19 2.31e-09 GO:0050794 regulation of cellular process
1.48 3.76e-09 GO:0006996 organelle organization
1.17 7.90e-09 GO:0050789 regulation of biological process
1.31 8.84e-09 GO:0006807 nitrogen compound metabolic process
1.62 1.55e-08 GO:0006357 regulation of transcription from RNA polymerase II promoter
1.45 2.46e-08 GO:0016070 RNA metabolic process
1.27 3.86e-08 GO:0019222 regulation of metabolic process
1.64 9.04e-08 GO:0006351 transcription, DNA-dependent
1.28 9.09e-08 GO:0031323 regulation of cellular metabolic process
1.36 1.08e-07 GO:0048519 negative regulation of biological process
1.29 1.25e-07 GO:0060255 regulation of macromolecule metabolic process
1.51 2.37e-07 GO:0009893 positive regulation of metabolic process
1.66 2.75e-07 GO:0046907 intracellular transport
2.63 3.49e-07 GO:0006184 GTP catabolic process
1.42 6.33e-07 GO:0009059 macromolecule biosynthetic process
1.42 6.92e-07 GO:0034645 cellular macromolecule biosynthetic process
1.36 9.12e-07 GO:0090304 nucleic acid metabolic process
1.69 1.02e-06 GO:0045595 regulation of cell differentiation
1.50 1.07e-06 GO:0031325 positive regulation of cellular metabolic process
1.58 1.20e-06 GO:0010605 negative regulation of macromolecule metabolic process
1.58 1.20e-06 GO:0050793 regulation of developmental process
1.36 1.23e-06 GO:0048523 negative regulation of cellular process
1.44 1.51e-06 GO:0007399 nervous system development
1.25 1.74e-06 GO:0023052 signaling
1.50 3.36e-06 GO:0010604 positive regulation of macromolecule metabolic process
1.26 3.91e-06 GO:0080090 regulation of primary metabolic process
1.63 3.99e-06 GO:0010557 positive regulation of macromolecule biosynthetic process
2.47 4.06e-06 GO:0046039 GTP metabolic process
1.58 4.78e-06 GO:0009891 positive regulation of biosynthetic process
1.32 4.87e-06 GO:0044267 cellular protein metabolic process
1.56 5.18e-06 GO:0031324 negative regulation of cellular metabolic process
1.46 6.14e-06 GO:0051641 cellular localization
1.53 6.26e-06 GO:0009892 negative regulation of metabolic process
1.58 7.81e-06 GO:0031328 positive regulation of cellular biosynthetic process
1.25 9.20e-06 GO:0051179 localization
1.37 9.98e-06 GO:0006464 protein modification process
1.64 1.37e-05 GO:0009719 response to endogenous stimulus
1.31 1.83e-05 GO:0048522 positive regulation of cellular process
1.55 2.42e-05 GO:0045184 establishment of protein localization
1.49 2.58e-05 GO:0008104 protein localization
1.23 2.82e-05 GO:0032502 developmental process
1.29 3.09e-05 GO:0048518 positive regulation of biological process
1.55 3.58e-05 GO:0015031 protein transport
1.47 3.83e-05 GO:0051649 establishment of localization in cell
1.27 4.07e-05 GO:0051234 establishment of localization
1.65 4.27e-05 GO:0009725 response to hormone stimulus
1.34 4.33e-05 GO:0043412 macromolecule modification
2.13 4.36e-05 GO:0009203 ribonucleoside triphosphate catabolic process
2.13 4.36e-05 GO:0009207 purine ribonucleoside triphosphate catabolic process
2.12 5.28e-05 GO:0009146 purine nucleoside triphosphate catabolic process
1.50 6.05e-05 GO:0032774 RNA biosynthetic process
1.42 6.14e-05 GO:0033036 macromolecule localization
1.89 6.68e-05 GO:0071495 cellular response to endogenous stimulus
1.51 6.77e-05 GO:0048468 cell development
1.62 7.01e-05 GO:0007167 enzyme linked receptor protein signaling pathway
2.09 9.29e-05 GO:0009143 nucleoside triphosphate catabolic process
2.09 9.29e-05 GO:0009154 purine ribonucleotide catabolic process
1.26 1.17e-04 GO:0006810 transport
1.64 1.21e-04 GO:0010629 negative regulation of gene expression
1.32 1.31e-04 GO:0048869 cellular developmental process
2.07 1.34e-04 GO:0009261 ribonucleotide catabolic process
1.56 1.45e-04 GO:0045935 positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.24 1.52e-04 GO:0007165 signal transduction
1.82 1.62e-04 GO:0010551 regulation of gene-specific transcription from RNA polymerase II promoter
1.90 1.65e-04 GO:0032870 cellular response to hormone stimulus
1.75 1.73e-04 GO:0032583 regulation of gene-specific transcription
1.54 1.88e-04 GO:0051173 positive regulation of nitrogen compound metabolic process
1.67 1.93e-04 GO:0045892 negative regulation of transcription, DNA-dependent
1.59 1.96e-04 GO:0010628 positive regulation of gene expression
1.32 2.18e-04 GO:0030154 cell differentiation
1.61 2.56e-04 GO:2000113 negative regulation of cellular macromolecule biosynthetic process
1.55 2.56e-04 GO:2000026 regulation of multicellular organismal development
2.00 3.04e-04 GO:0006195 purine nucleotide catabolic process
1.59 3.19e-04 GO:0010558 negative regulation of macromolecule biosynthetic process
1.98 3.45e-04 GO:0072523 purine-containing compound catabolic process
1.57 3.53e-04 GO:0031327 negative regulation of cellular biosynthetic process
1.24 3.66e-04 GO:0048856 anatomical structure development
1.60 3.82e-04 GO:0045893 positive regulation of transcription, DNA-dependent
1.27 4.17e-04 GO:0009058 biosynthetic process
1.46 4.34e-04 GO:0032268 regulation of cellular protein metabolic process
1.51 5.24e-04 GO:0051128 regulation of cellular component organization
1.82 5.74e-04 GO:0043434 response to peptide hormone stimulus
1.63 5.76e-04 GO:0051253 negative regulation of RNA metabolic process
1.70 6.59e-04 GO:0051094 positive regulation of developmental process
1.65 6.63e-04 GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
1.35 6.78e-04 GO:0023051 regulation of signaling
1.55 6.82e-04 GO:0009890 negative regulation of biosynthetic process
1.81 7.09e-04 GO:0009259 ribonucleotide metabolic process
1.36 7.87e-04 GO:0009653 anatomical structure morphogenesis
1.47 8.39e-04 GO:0022008 neurogenesis
1.22 8.71e-04 GO:0007275 multicellular organismal development
1.58 9.26e-04 GO:0045934 negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.82 1.01e-03 GO:0060284 regulation of cell development
2.11 1.03e-03 GO:0051169 nuclear transport
1.78 1.05e-03 GO:0018193 peptidyl-amino acid modification
1.25 1.05e-03 GO:0031326 regulation of cellular biosynthetic process
1.27 1.09e-03 GO:0044249 cellular biosynthetic process
1.55 1.11e-03 GO:0051254 positive regulation of RNA metabolic process
1.67 1.13e-03 GO:0045944 positive regulation of transcription from RNA polymerase II promoter
1.28 1.15e-03 GO:0042221 response to chemical stimulus
1.42 1.21e-03 GO:0051246 regulation of protein metabolic process
1.72 1.43e-03 GO:0000122 negative regulation of transcription from RNA polymerase II promoter
1.26 1.49e-03 GO:0010468 regulation of gene expression
1.79 1.50e-03 GO:0045597 positive regulation of cell differentiation
1.87 1.63e-03 GO:0010608 posttranscriptional regulation of gene expression
1.47 1.74e-03 GO:0048699 generation of neurons
1.38 1.80e-03 GO:0051239 regulation of multicellular organismal process
1.56 1.82e-03 GO:0051172 negative regulation of nitrogen compound metabolic process
2.09 1.84e-03 GO:0006913 nucleocytoplasmic transport
1.25 1.94e-03 GO:0009889 regulation of biosynthetic process
1.89 1.97e-03 GO:0009166 nucleotide catabolic process
1.83 2.04e-03 GO:0009144 purine nucleoside triphosphate metabolic process
1.38 2.24e-03 GO:0010033 response to organic substance
1.36 2.26e-03 GO:0035556 intracellular signal transduction
1.81 2.50e-03 GO:0009141 nucleoside triphosphate metabolic process
2.88 2.51e-03 GO:0031124 mRNA 3'-end processing
1.68 2.59e-03 GO:0072521 purine-containing compound metabolic process
1.71 2.75e-03 GO:0006397 mRNA processing
1.59 3.22e-03 GO:0016071 mRNA metabolic process
1.78 3.22e-03 GO:0009150 purine ribonucleotide metabolic process
1.81 3.32e-03 GO:0009199 ribonucleoside triphosphate metabolic process
1.19 3.47e-03 GO:0051716 cellular response to stimulus
1.95 4.40e-03 GO:0043193 positive regulation of gene-specific transcription
1.91 4.41e-03 GO:0051129 negative regulation of cellular component organization
1.34 4.94e-03 GO:0009966 regulation of signal transduction
1.24 4.99e-03 GO:0019219 regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.82 5.44e-03 GO:0034655 nucleobase, nucleoside, nucleotide and nucleic acid catabolic process
1.82 5.44e-03 GO:0034656 nucleobase, nucleoside and nucleotide catabolic process
1.78 6.03e-03 GO:0022603 regulation of anatomical structure morphogenesis
1.68 6.07e-03 GO:0006163 purine nucleotide metabolic process
1.79 6.16e-03 GO:0009205 purine ribonucleoside triphosphate metabolic process
2.23 7.42e-03 GO:0010769 regulation of cell morphogenesis involved in differentiation
3.38 7.79e-03 GO:0060349 bone morphogenesis
1.37 8.73e-03 GO:0044085 cellular component biogenesis
2.21 9.16e-03 GO:0022604 regulation of cell morphogenesis
1.39 1.01e-02 GO:0022607 cellular component assembly
1.24 1.04e-02 GO:0010556 regulation of macromolecule biosynthetic process
2.06 1.07e-02 GO:0010552 positive regulation of gene-specific transcription from RNA polymerase II promoter
1.82 1.10e-02 GO:0045596 negative regulation of cell differentiation
1.22 1.11e-02 GO:0048731 system development
1.22 1.11e-02 GO:0019538 protein metabolic process
1.81 1.56e-02 GO:0030334 regulation of cell migration
1.48 1.64e-02 GO:0065003 macromolecular complex assembly
2.67 1.87e-02 GO:0051147 regulation of muscle cell differentiation
1.50 1.93e-02 GO:0032989 cellular component morphogenesis
1.61 1.96e-02 GO:0007268 synaptic transmission
1.44 2.17e-02 GO:0031399 regulation of protein modification process
1.57 2.23e-02 GO:0019226 transmission of nerve impulse
1.57 2.23e-02 GO:0035637 multicellular organismal signaling
1.24 2.24e-02 GO:2000112 regulation of cellular macromolecule biosynthetic process
1.79 2.34e-02 GO:2000145 regulation of cell motility
1.28 2.35e-02 GO:0044281 small molecule metabolic process
1.85 2.38e-02 GO:0071375 cellular response to peptide hormone stimulus
2.52 2.52e-02 GO:0031123 RNA 3'-end processing
1.22 2.52e-02 GO:0051171 regulation of nitrogen compound metabolic process
1.39 2.65e-02 GO:0032879 regulation of localization
1.74 2.85e-02 GO:0051270 regulation of cellular component movement
1.97 2.92e-02 GO:0030900 forebrain development
1.73 2.97e-02 GO:0006366 transcription from RNA polymerase II promoter
1.55 3.58e-02 GO:0007010 cytoskeleton organization
1.83 3.64e-02 GO:0032868 response to insulin stimulus
1.52 3.66e-02 GO:0055086 nucleobase, nucleoside and nucleotide metabolic process
1.50 3.76e-02 GO:0000902 cell morphogenesis
1.54 3.85e-02 GO:0070727 cellular macromolecule localization
1.48 3.99e-02 GO:0071310 cellular response to organic substance
1.54 4.26e-02 GO:0006753 nucleoside phosphate metabolic process
1.54 4.26e-02 GO:0009117 nucleotide metabolic process
1.70 4.42e-02 GO:0046700 heterocycle catabolic process
1.67 4.51e-02 GO:0003006 developmental process involved in reproduction
1.37 4.95e-02 GO:0007154 cell communication

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.16 1.58e-28 GO:0005622 intracellular
1.16 1.90e-25 GO:0044424 intracellular part
1.20 2.80e-19 GO:0043231 intracellular membrane-bounded organelle
1.20 4.73e-19 GO:0043227 membrane-bounded organelle
1.17 1.44e-18 GO:0043229 intracellular organelle
1.17 1.48e-18 GO:0043226 organelle
1.20 5.04e-17 GO:0005737 cytoplasm
1.25 5.07e-14 GO:0005634 nucleus
1.24 1.17e-12 GO:0044446 intracellular organelle part
1.23 9.30e-12 GO:0044422 organelle part
1.41 1.11e-11 GO:0031974 membrane-enclosed lumen
1.42 1.16e-11 GO:0070013 intracellular organelle lumen
1.41 3.85e-11 GO:0043233 organelle lumen
1.21 4.06e-11 GO:0044444 cytoplasmic part
1.45 2.59e-10 GO:0031981 nuclear lumen
1.40 4.80e-10 GO:0044428 nuclear part
1.05 1.19e-08 GO:0044464 cell part
1.05 1.25e-08 GO:0005623 cell
1.49 1.35e-08 GO:0005654 nucleoplasm
1.38 2.39e-08 GO:0005829 cytosol
1.27 1.44e-05 GO:0043228 non-membrane-bounded organelle
1.27 1.44e-05 GO:0043232 intracellular non-membrane-bounded organelle
1.20 5.67e-04 GO:0032991 macromolecular complex
1.50 7.08e-03 GO:0005694 chromosome
1.20 7.66e-03 GO:0043234 protein complex
1.27 1.64e-02 GO:0012505 endomembrane system
1.23 1.76e-02 GO:0031090 organelle membrane
1.40 2.38e-02 GO:0044451 nucleoplasm part

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.27 4.32e-25 GO:0005515 protein binding
1.13 2.68e-18 GO:0005488 binding
1.47 2.69e-15 GO:0000166 nucleotide binding
1.48 5.88e-12 GO:0035639 purine ribonucleoside triphosphate binding
1.46 2.28e-11 GO:0032553 ribonucleotide binding
1.46 2.28e-11 GO:0032555 purine ribonucleotide binding
1.46 3.06e-11 GO:0017076 purine nucleotide binding
1.98 4.80e-08 GO:0005525 GTP binding
1.92 2.83e-07 GO:0019001 guanyl nucleotide binding
1.92 2.83e-07 GO:0032561 guanyl ribonucleotide binding
2.24 5.38e-07 GO:0003924 GTPase activity
1.66 5.59e-07 GO:0043565 sequence-specific DNA binding
1.51 2.19e-06 GO:0030528 transcription regulator activity
1.49 1.22e-05 GO:0001071 nucleic acid binding transcription factor activity
1.49 1.22e-05 GO:0003700 sequence-specific DNA binding transcription factor activity
1.55 3.61e-05 GO:0019899 enzyme binding
1.22 1.23e-04 GO:0003676 nucleic acid binding
1.49 1.45e-04 GO:0003723 RNA binding
1.35 1.82e-04 GO:0005524 ATP binding
1.46 2.22e-04 GO:0016772 transferase activity, transferring phosphorus-containing groups
1.34 3.08e-04 GO:0032559 adenyl ribonucleotide binding
1.34 3.35e-04 GO:0030554 adenyl nucleotide binding
1.49 1.01e-03 GO:0016773 phosphotransferase activity, alcohol group as acceptor
1.94 1.32e-03 GO:0000975 regulatory region DNA binding
1.94 1.32e-03 GO:0001067 regulatory region nucleic acid binding
1.94 1.32e-03 GO:0044212 transcription regulatory region DNA binding
1.77 1.75e-03 GO:0008134 transcription factor binding
1.46 1.82e-03 GO:0016301 kinase activity
1.95 2.01e-03 GO:0010843 promoter binding
1.29 2.97e-03 GO:0016740 transferase activity
1.72 3.28e-03 GO:0016563 transcription activator activity
1.55 1.96e-02 GO:0004674 protein serine/threonine kinase activity
1.22 2.59e-02 GO:0003677 DNA binding
1.44 3.74e-02 GO:0004672 protein kinase activity