Motif ID: ATF6.p2

Z-value: 1.479


Transcription factors associated with ATF6.p2:

Gene SymbolEntrez IDGene Name
ATF6 22926 activating transcription factor 6

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.p-valuePlot
ATF6chr1_+_1617361090.164.3e-01Click!


Activity profile for motif ATF6.p2.

activity profile for motif ATF6.p2


Sorted Z-values histogram for motif ATF6.p2

Sorted Z-values for motif ATF6.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of ATF6.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr8_-_22550708 5.729 NM_004430
EGR3
early growth response 3
chr12_-_124068864 4.410


chr7_+_94024201 3.255 COL1A2
collagen, type I, alpha 2
chr5_-_172198160 3.249 NM_004417
DUSP1
dual specificity phosphatase 1
chr2_+_28615771 3.113 NM_005253
FOSL2
FOS-like antigen 2
chr10_-_64576074 2.853 EGR2
early growth response 2
chr10_-_64576123 2.827 NM_000399
NM_001136177
NM_001136179
EGR2


early growth response 2


chr9_-_84304378 2.782 TLE1
transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
chr2_+_28615668 2.773 FOSL2
FOS-like antigen 2
chr16_-_88772732 2.671 NM_001171815
RNF166
ring finger protein 166
chr1_+_84767288 2.644 NM_001134663
SAMD13
sterile alpha motif domain containing 13
chr16_-_88772807 2.635 NM_178841
RNF166
ring finger protein 166
chr12_+_27397077 2.589 NM_015000
STK38L
serine/threonine kinase 38 like
chr8_-_9009050 2.565 NM_001201329
PPP1R3B
protein phosphatase 1, regulatory subunit 3B
chr3_+_8543508 2.549 NM_014583
LMCD1
LIM and cysteine-rich domains 1
chr9_+_79074067 2.469 NM_001097633
NM_001490
GCNT1

glucosaminyl (N-acetyl) transferase 1, core 2

chr2_+_28615695 2.447 FOSL2
FOS-like antigen 2
chr5_+_137801166 2.431 EGR1
early growth response 1
chr7_+_94023872 2.413 NM_000089
COL1A2
collagen, type I, alpha 2
chr11_+_7535000 2.276 NM_003621
PPFIBP2
PTPRF interacting protein, binding protein 2 (liprin beta 2)
chr7_-_27224762 2.248 NM_005523
HOXA11
homeobox A11
chr18_+_72922725 2.096 NM_005786
TSHZ1
teashirt zinc finger homeobox 1
chr8_+_120220554 2.016 NM_052886
MAL2
mal, T-cell differentiation protein 2 (gene/pseudogene)
chr11_+_7535213 2.011 PPFIBP2
PTPRF interacting protein, binding protein 2 (liprin beta 2)
chr17_-_46688279 1.980 HOXB7
homeobox B7
chr3_+_193853937 1.969 HES1
hairy and enhancer of split 1, (Drosophila)
chr5_+_137801178 1.885 NM_001964
EGR1
early growth response 1
chr17_-_46688362 1.838 NM_004502
HOXB7
homeobox B7
chr3_+_193853930 1.837 NM_005524
HES1
hairy and enhancer of split 1, (Drosophila)
chr17_-_46687925 1.782 HOXB7
homeobox B7
chr8_+_27491384 1.779 SCARA3
scavenger receptor class A, member 3
chr7_+_27225009 1.739 HOXA11-AS1
HOXA11 antisense RNA 1 (non-protein coding)
chr16_+_53164784 1.732 CHD9
chromodomain helicase DNA binding protein 9
chr11_-_119234628 1.720 USP2
ubiquitin specific peptidase 2
chr19_+_6772801 1.695


chr3_+_170075449 1.686 NM_001145098
NM_005414
SKIL

SKI-like oncogene

chr3_-_33759540 1.660 CLASP2
cytoplasmic linker associated protein 2
chr10_+_112257624 1.655 NM_004419
DUSP5
dual specificity phosphatase 5
chrX_+_118108575 1.654 LONRF3
LON peptidase N-terminal domain and ring finger 3
chr3_+_8543539 1.637 LMCD1
LIM and cysteine-rich domains 1
chr9_-_125027080 1.630 NM_033117
RBM18
RNA binding motif protein 18
chr3_-_187463227 1.563 BCL6
B-cell CLL/lymphoma 6
chr11_-_66445218 1.561 NM_031492
RBM4B
RNA binding motif protein 4B
chr9_-_131709783 1.440 NM_014908
DOLK
dolichol kinase
chr5_+_112849352 1.413 NM_022828
YTHDC2
YTH domain containing 2
chr6_-_84418705 1.411 NM_001242792
SNAP91
synaptosomal-associated protein, 91kDa homolog (mouse)
chr19_-_47617008 1.396 NM_015168
ZC3H4
zinc finger CCCH-type containing 4
chr10_-_32217687 1.384 ARHGAP12
Rho GTPase activating protein 12
chr20_-_25038501 1.379 NM_001252675
NM_001252677
NM_032501
ACSS1


acyl-CoA synthetase short-chain family member 1


chr2_-_157189040 1.372 NM_006186
NR4A2
nuclear receptor subfamily 4, group A, member 2
chr12_+_56660724 1.370 COQ10A
coenzyme Q10 homolog A (S. cerevisiae)
chr21_+_38445562 1.367 NM_001001894
TTC3
tetratricopeptide repeat domain 3
chr13_-_49107250 1.359 NM_001268
RCBTB2
regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
chr4_+_100871625 1.357 LOC256880
uncharacterized LOC256880
chr12_+_56660913 1.348 COQ10A
coenzyme Q10 homolog A (S. cerevisiae)
chr2_-_28113954 1.343 LOC100302650
uncharacterized LOC100302650
chr12_+_56660548 1.321 NM_144576
COQ10A
coenzyme Q10 homolog A (S. cerevisiae)
chr8_-_95274540 1.317 NM_005261
NM_181702
GEM

GTP binding protein overexpressed in skeletal muscle

chr12_+_56661026 1.309 NM_001099337
COQ10A
coenzyme Q10 homolog A (S. cerevisiae)
chr7_+_44646168 1.303 OGDH
oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide)
chr4_-_18023358 1.286 NM_001166139
NM_153686
LCORL

ligand dependent nuclear receptor corepressor-like

chr1_-_47184790 1.283


chr13_-_101327027 1.283 TMTC4
transmembrane and tetratricopeptide repeat containing 4
chr4_+_170541690 1.275 CLCN3
chloride channel 3
chr21_-_44846927 1.272 NM_173354
SIK1
salt-inducible kinase 1
chr15_-_101792125 1.271 NM_014918
CHSY1
chondroitin sulfate synthase 1
chr2_-_198540583 1.263 NM_144629
RFTN2
raftlin family member 2
chr7_-_129592794 1.250 NM_003344
NM_182697
UBE2H

ubiquitin-conjugating enzyme E2H

chr14_+_68086633 1.250 ARG2
arginase, type II
chr3_-_33759684 1.250 NM_015097
CLASP2
cytoplasmic linker associated protein 2
chr13_-_49107357 1.244 RCBTB2
regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
chr7_+_44646189 1.237 OGDH
oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide)
chr7_-_129592711 1.234 NM_001202498
UBE2H
ubiquitin-conjugating enzyme E2H
chr13_-_101327102 1.225 NM_001079669
NM_032813
TMTC4

transmembrane and tetratricopeptide repeat containing 4

chrX_+_118108595 1.216 NM_001031855
NM_024778
LONRF3

LON peptidase N-terminal domain and ring finger 3

chr2_+_11052062 1.199 NM_002236
KCNF1
potassium voltage-gated channel, subfamily F, member 1
chr1_+_222791151 1.178 NM_198551
MIA3
melanoma inhibitory activity family, member 3
chr12_+_20522178 1.166 NM_000921
PDE3A
phosphodiesterase 3A, cGMP-inhibited
chr3_+_100211554 1.160 TMEM45A
transmembrane protein 45A
chr8_-_81083660 1.148 NM_001025253
NM_005079
TPD52

tumor protein D52

chr1_+_15250578 1.145 NM_001018000
KAZN
kazrin, periplakin interacting protein
chr12_-_124018066 1.144 NM_178314
RILPL1
Rab interacting lysosomal protein-like 1
chr3_-_122512526 1.141 NM_024610
HSPBAP1
HSPB (heat shock 27kDa) associated protein 1
chr11_-_67888670 1.138 CHKA
choline kinase alpha
chr7_+_44646197 1.128 OGDH
oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide)
chr3_-_18480203 1.120 NM_001131010
SATB1
SATB homeobox 1
chr8_-_93115453 1.113 NM_001198633
NM_175634
RUNX1T1

runt-related transcription factor 1; translocated to, 1 (cyclin D-related)

chr10_+_94833646 1.111 NM_000783
CYP26A1
cytochrome P450, family 26, subfamily A, polypeptide 1
chr14_-_23822025 1.110 NM_016609
SLC22A17
solute carrier family 22, member 17
chr3_+_100211408 1.098 NM_018004
TMEM45A
transmembrane protein 45A
chr8_+_29952971 1.096 LEPROTL1
leptin receptor overlapping transcript-like 1
chr11_+_9595451 1.087 WEE1
WEE1 homolog (S. pombe)
chr1_+_87794576 1.083 LMO4
LIM domain only 4
chr5_+_172483285 1.081 NM_001168393
NM_001168394
NM_153607
C5orf41


chromosome 5 open reading frame 41


chr13_-_49107185 1.080 RCBTB2
regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
chr8_-_95274520 1.077 GEM
GTP binding protein overexpressed in skeletal muscle
chr3_-_187463474 1.075 NM_001706
BCL6
B-cell CLL/lymphoma 6
chr2_+_219745243 1.075 NM_025216
WNT10A
wingless-type MMTV integration site family, member 10A
chr17_-_49337370 1.069 NM_017643
MBTD1
mbt domain containing 1
chr5_-_132299248 1.055 AFF4
AF4/FMR2 family, member 4
chr19_-_42759279 1.050 NM_006494
ERF
Ets2 repressor factor
chr2_-_225266710 1.047 NM_001122779
NM_024785
FAM124B

family with sequence similarity 124B

chr15_-_82338348 1.042 NM_032246
MEX3B
mex-3 homolog B (C. elegans)
chr9_+_35906188 1.034 NM_001039792
HRCT1
histidine rich carboxyl terminus 1
chr7_+_12726413 1.029 NM_001037164
NM_212460
ARL4A

ADP-ribosylation factor-like 4A

chr6_-_6007632 1.020 NM_016588
NRN1
neuritin 1
chr4_+_170541728 1.019 CLCN3
chloride channel 3
chr1_+_221052735 1.017 NM_021958
HLX
H2.0-like homeobox
chr10_+_35416089 1.014 CREM
cAMP responsive element modulator
chr3_+_158519888 1.013 MFSD1
major facilitator superfamily domain containing 1
chr12_+_107168336 1.001 NM_018157
RIC8B
resistance to inhibitors of cholinesterase 8 homolog B (C. elegans)
chr1_+_33004969 1.000 ZBTB8A
zinc finger and BTB domain containing 8A
chr14_-_77494974 0.998 NM_024496
IRF2BPL
interferon regulatory factor 2 binding protein-like
chr8_-_17658385 0.995 NM_001001924
NM_001001925
MTUS1

microtubule associated tumor suppressor 1

chr10_+_99079017 0.995 NM_005479
FRAT1
frequently rearranged in advanced T-cell lymphomas
chr6_+_122720685 0.974 NM_001135564
NM_001243094
NM_004506
HSF2


heat shock transcription factor 2


chr9_-_125027017 0.972 RBM18
RNA binding motif protein 18
chr12_+_93964801 0.970 SOCS2
suppressor of cytokine signaling 2
chr2_+_176987412 0.968 NM_014213
HOXD9
homeobox D9
chr17_-_35716024 0.961 NM_198836
ACACA
acetyl-CoA carboxylase alpha
chr2_+_191745568 0.953 GLS
glutaminase
chr11_+_9595183 0.952 NM_003390
WEE1
WEE1 homolog (S. pombe)
chr15_-_52030162 0.951 NM_153374
LYSMD2
LysM, putative peptidoglycan-binding, domain containing 2
chr15_-_82338459 0.950 MEX3B
mex-3 homolog B (C. elegans)
chr7_+_16793320 0.947 NM_014399
TSPAN13
tetraspanin 13
chr12_+_9067130 0.940 NM_004426
PHC1
polyhomeotic homolog 1 (Drosophila)
chr5_+_53813494 0.938 NM_001145427
NM_001102575
NM_052870
SNX18


sorting nexin 18


chr19_-_42759151 0.937 ERF
Ets2 repressor factor
chr7_+_65338343 0.932 VKORC1L1
vitamin K epoxide reductase complex, subunit 1-like 1
chr2_+_207139413 0.932 NM_020923
ZDBF2
zinc finger, DBF-type containing 2
chr2_-_21022812 0.919 NM_021925
C2orf43
chromosome 2 open reading frame 43
chr14_+_74551655 0.916 NM_001024674
LIN52
lin-52 homolog (C. elegans)
chr7_+_65338349 0.914 VKORC1L1
vitamin K epoxide reductase complex, subunit 1-like 1
chr6_-_6007097 0.905 NRN1
neuritin 1
chr11_+_9595309 0.900 WEE1
WEE1 homolog (S. pombe)
chr1_+_37940180 0.899 ZC3H12A
zinc finger CCCH-type containing 12A
chr1_-_91487543 0.896 ZNF644
zinc finger protein 644
chr18_-_12702631 0.896 NM_024899
CEP76
centrosomal protein 76kDa
chr12_-_76425375 0.888 NM_007350
PHLDA1
pleckstrin homology-like domain, family A, member 1
chr4_-_57253588 0.880 NM_181806
AASDH
aminoadipate-semialdehyde dehydrogenase
chr1_+_37940074 0.879 NM_025079
ZC3H12A
zinc finger CCCH-type containing 12A
chr17_+_7761310 0.876 CYB5D1
cytochrome b5 domain containing 1
chr6_-_7910278 0.875 NM_001145549
TXNDC5
thioredoxin domain containing 5 (endoplasmic reticulum)
chr10_+_35416384 0.874 NM_181571
NM_183060
CREM

cAMP responsive element modulator

chr1_+_52082755 0.869 OSBPL9
oxysterol binding protein-like 9
chr2_+_191208326 0.867 INPP1
inositol polyphosphate-1-phosphatase
chr5_+_74632992 0.865 NM_000859
NM_001130996
HMGCR

3-hydroxy-3-methylglutaryl-CoA reductase

chr4_-_39640461 0.864 NM_174921
C4orf34
chromosome 4 open reading frame 34
chr7_-_100808832 0.860 NM_003378
VGF
VGF nerve growth factor inducible
chr16_+_81812899 0.859 PLCG2
phospholipase C, gamma 2 (phosphatidylinositol-specific)
chr9_+_131644427 0.858 LRRC8A
leucine rich repeat containing 8 family, member A
chr6_+_127587984 0.853 RNF146
ring finger protein 146
chr16_+_81812897 0.851 NM_002661
PLCG2
phospholipase C, gamma 2 (phosphatidylinositol-specific)
chr17_-_57184116 0.847 TRIM37
tripartite motif containing 37
chr21_-_38445389 0.845 NM_153682
PIGP
phosphatidylinositol glycan anchor biosynthesis, class P
chr3_+_184529871 0.842 NM_001009921
NM_015303
VPS8

vacuolar protein sorting 8 homolog (S. cerevisiae)

chr4_-_114682340 0.838 CAMK2D
calcium/calmodulin-dependent protein kinase II delta
chr11_-_66445318 0.837 RBM4B
RNA binding motif protein 4B
chr17_+_25621105 0.834 NM_015626
NM_134265
WSB1

WD repeat and SOCS box containing 1

chr13_+_114238978 0.832 TFDP1
transcription factor Dp-1
chr16_+_29827489 0.813 NM_024516
C16orf53
chromosome 16 open reading frame 53
chr2_-_105946104 0.805 NM_001142621
NM_004257
TGFBRAP1

transforming growth factor, beta receptor associated protein 1

chr4_+_76649806 0.803 USO1
USO1 vesicle docking protein homolog (yeast)
chr4_+_75310852 0.803 NM_001657
AREG
amphiregulin
chr8_+_29952921 0.797 NM_001128208
NM_015344
LEPROTL1

leptin receptor overlapping transcript-like 1

chr16_+_81812925 0.796 PLCG2
phospholipase C, gamma 2 (phosphatidylinositol-specific)
chr12_-_122751044 0.795 NM_022916
VPS33A
vacuolar protein sorting 33 homolog A (S. cerevisiae)
chr17_-_66951381 0.792 NM_007168
ABCA8
ATP-binding cassette, sub-family A (ABC1), member 8
chr1_+_37940129 0.788 ZC3H12A
zinc finger CCCH-type containing 12A
chr3_+_23987514 0.783 NM_001145425
NR1D2
nuclear receptor subfamily 1, group D, member 2
chr1_-_47184730 0.777 NM_014774
KIAA0494
KIAA0494
chr10_+_23728197 0.777 NM_001145373
OTUD1
OTU domain containing 1
chr2_+_113403433 0.775 NM_005415
SLC20A1
solute carrier family 20 (phosphate transporter), member 1
chr1_+_66999805 0.774 NM_032291
SGIP1
SH3-domain GRB2-like (endophilin) interacting protein 1
chr21_-_38444814 0.773 NM_153681
PIGP
phosphatidylinositol glycan anchor biosynthesis, class P
chr2_-_172016904 0.764 TLK1
tousled-like kinase 1
chrX_-_62974341 0.760 ARHGEF9
Cdc42 guanine nucleotide exchange factor (GEF) 9
chr12_-_57824787 0.752 R3HDM2
R3H domain containing 2
chr12_+_124069080 0.750 TMED2
transmembrane emp24 domain trafficking protein 2
chr2_+_191745547 0.748 GLS
glutaminase
chr12_-_122750954 0.747 VPS33A
vacuolar protein sorting 33 homolog A (S. cerevisiae)
chr11_+_9595429 0.747 WEE1
WEE1 homolog (S. pombe)
chr14_-_64970319 0.738 NM_006977
ZBTB25
zinc finger and BTB domain containing 25
chr9_+_102584136 0.737 NM_006981
NM_173199
NM_173200
NR4A3


nuclear receptor subfamily 4, group A, member 3


chr10_+_119301955 0.736 NM_001165924
NM_004098
EMX2

empty spiracles homeobox 2

chr6_-_111927059 0.727 TRAF3IP2
TRAF3 interacting protein 2
chr8_+_42195972 0.726 NM_002690
POLB
polymerase (DNA directed), beta
chr20_-_23066828 0.723 NM_012072
CD93
CD93 molecule
chr3_+_37903643 0.720 NM_001008392
NM_005808
CTDSPL

CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like

chr15_-_73076025 0.714 ADPGK
ADP-dependent glucokinase
chr13_-_36920491 0.713 SPG20
spastic paraplegia 20 (Troyer syndrome)
chr9_-_79520878 0.712 NM_015225
PRUNE2
prune homolog 2 (Drosophila)
chr3_+_170075494 0.710 SKIL
SKI-like oncogene
chr6_-_80656870 0.706 NM_022726
ELOVL4
ELOVL fatty acid elongase 4
chr16_-_3627353 0.704 NM_178844
NLRC3
NLR family, CARD domain containing 3
chr14_-_74226890 0.701 NM_194278
C14orf43
chromosome 14 open reading frame 43
chr4_-_146019296 0.699 NM_014885
ANAPC10
anaphase promoting complex subunit 10
chr9_-_86432546 0.697 NM_001135953
NM_025211
GKAP1

G kinase anchoring protein 1

chr16_-_67184822 0.696 NM_033309
B3GNT9
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 9
chr8_+_68864341 0.693 PREX2
phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.78 3.85e-06 GO:0008104 protein localization
2.13 1.39e-05 GO:0070727 cellular macromolecule localization
1.84 1.89e-05 GO:0015031 protein transport
2.11 2.61e-05 GO:0034613 cellular protein localization
1.81 4.55e-05 GO:0045184 establishment of protein localization
1.63 6.27e-05 GO:0033036 macromolecule localization
1.63 1.51e-04 GO:0051641 cellular localization
7.73 2.83e-04 GO:0048199 vesicle targeting, to, from or within Golgi
1.28 5.98e-04 GO:0044260 cellular macromolecule metabolic process
2.14 7.21e-04 GO:0006886 intracellular protein transport
1.24 2.46e-03 GO:0043170 macromolecule metabolic process
1.20 2.49e-03 GO:0044237 cellular metabolic process
1.72 4.02e-03 GO:0046907 intracellular transport
1.11 5.61e-03 GO:0009987 cellular process
2.81 8.39e-03 GO:0048193 Golgi vesicle transport
1.17 9.62e-03 GO:0008152 metabolic process
10.31 1.14e-02 GO:0048194 Golgi vesicle budding
10.31 1.14e-02 GO:0048200 Golgi transport vesicle coating
10.31 1.14e-02 GO:0048205 COPI coating of Golgi vesicle
1.55 1.95e-02 GO:0051649 establishment of localization in cell
5.80 2.32e-02 GO:0006901 vesicle coating
5.16 2.52e-02 GO:0006903 vesicle targeting
1.18 2.96e-02 GO:0044238 primary metabolic process
5.57 3.42e-02 GO:0006900 membrane budding

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.23 1.68e-11 GO:0043231 intracellular membrane-bounded organelle
1.23 2.22e-11 GO:0043227 membrane-bounded organelle
1.16 4.59e-11 GO:0044424 intracellular part
1.14 2.00e-09 GO:0005622 intracellular
1.18 1.08e-08 GO:0043229 intracellular organelle
1.18 1.67e-08 GO:0043226 organelle
1.27 1.01e-06 GO:0044446 intracellular organelle part
1.59 1.51e-06 GO:0012505 endomembrane system
1.19 1.83e-06 GO:0005737 cytoplasm
1.25 2.88e-06 GO:0044444 cytoplasmic part
1.25 4.98e-06 GO:0044422 organelle part
2.11 7.28e-06 GO:0000139 Golgi membrane
1.95 2.15e-05 GO:0044431 Golgi apparatus part
1.42 1.83e-04 GO:0031090 organelle membrane
1.21 5.96e-04 GO:0005634 nucleus
1.58 8.31e-04 GO:0005783 endoplasmic reticulum
1.37 2.74e-03 GO:0044428 nuclear part
1.57 3.12e-03 GO:0005794 Golgi apparatus
7.73 4.03e-03 GO:0030663 COPI coated vesicle membrane
1.61 1.46e-02 GO:0044432 endoplasmic reticulum part
1.37 1.58e-02 GO:0031981 nuclear lumen
6.37 1.92e-02 GO:0030137 COPI-coated vesicle
1.44 2.04e-02 GO:0005654 nucleoplasm

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.09 2.79e-03 GO:0005488 binding
1.55 9.18e-03 GO:0001071 nucleic acid binding transcription factor activity
1.55 9.18e-03 GO:0003700 sequence-specific DNA binding transcription factor activity
15.47 9.43e-03 GO:0046923 ER retention sequence binding
1.14 3.13e-02 GO:0005515 protein binding