Motif ID: CDC5L.p2

Z-value: 0.900


Transcription factors associated with CDC5L.p2:

Gene SymbolEntrez IDGene Name
CDC5L 988 CDC5 cell division cycle 5-like (S. pombe)

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.p-valuePlot
CDC5Lchr6_+_44355250-0.395.5e-02Click!


Activity profile for motif CDC5L.p2.

activity profile for motif CDC5L.p2


Sorted Z-values histogram for motif CDC5L.p2

Sorted Z-values for motif CDC5L.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of CDC5L.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr2_+_228678556 5.749 NM_001130046
NM_004591
CCL20

chemokine (C-C motif) ligand 20

chr4_+_74606222 5.494 NM_000584
IL8
interleukin 8
chr4_-_76957139 4.916 NM_005409
CXCL11
chemokine (C-X-C motif) ligand 11
chr21_+_43619798 3.918 NM_207627
NM_207628
ABCG1

ATP-binding cassette, sub-family G (WHITE), member 1

chr1_-_89488412 2.957 NM_018284
GBP3
guanylate binding protein 3
chr18_+_61554938 2.699 NM_001143818
NM_002575
SERPINB2

serpin peptidase inhibitor, clade B (ovalbumin), member 2

chr6_+_127898318 2.541 NM_001010905
C6orf58
chromosome 6 open reading frame 58
chr10_+_111765725 2.308 NM_019903
ADD3
adducin 3 (gamma)
chr1_-_150738292 2.280 NM_001199739
NM_004079
CTSS

cathepsin S

chr1_-_150738255 2.047 CTSS
cathepsin S
chr1_-_150738232 1.965 CTSS
cathepsin S
chr8_+_104310660 1.747 NM_001164615
FZD6
frizzled family receptor 6
chrX_-_83757398 1.743 NM_001177478
NM_001177479
NM_144657
HDX


highly divergent homeobox


chr7_+_28452143 1.626 NM_182898
CREB5
cAMP responsive element binding protein 5
chr15_-_55562483 1.623 NM_183234
NM_004580
RAB27A

RAB27A, member RAS oncogene family

chr11_+_19372270 1.587 NM_001111018
NAV2
neuron navigator 2
chr3_-_71542628 1.484 FOXP1
forkhead box P1
chr8_+_104311058 1.340 NM_001164616
NM_003506
FZD6

frizzled family receptor 6

chr1_-_89530890 1.313 NM_002053
GBP1
guanylate binding protein 1, interferon-inducible
chr12_-_91398757 1.304 NM_004950
EPYC
epiphycan
chr1_-_89591685 1.284 NM_004120
GBP2
guanylate binding protein 2, interferon-inducible
chr20_-_34243118 1.225 RBM12
RNA binding motif protein 12
chr6_+_14117486 1.181 NM_001251901
CD83
CD83 molecule
chr6_-_32812711 1.179 NM_004159
PSMB8
proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional peptidase 7)
chr6_+_4890225 1.115 NM_001143971
CDYL
chromodomain protein, Y-like
chr4_-_122148620 1.082 NM_001244764
TNIP3
TNFAIP3 interacting protein 3
chr15_+_62359175 1.072 NM_207322
C2CD4A
C2 calcium-dependent domain containing 4A
chr17_-_7493389 1.072 NM_006942
SOX15
SRY (sex determining region Y)-box 15
chr10_+_126630691 1.053 NM_017580
ZRANB1
zinc finger, RAN-binding domain containing 1
chr11_-_102651321 1.019 NM_002425
MMP10
matrix metallopeptidase 10 (stromelysin 2)
chr6_+_55039070 1.000 NM_001526
HCRTR2
hypocretin (orexin) receptor 2
chr18_+_55888838 0.949 NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like
chr2_+_102508333 0.910 MAP4K4
mitogen-activated protein kinase kinase kinase kinase 4
chr7_+_18535351 0.879 NM_001204145
NM_001204146
NM_014707
NM_178423
HDAC9



histone deacetylase 9



chr2_+_102508377 0.859 MAP4K4
mitogen-activated protein kinase kinase kinase kinase 4
chr1_-_86043932 0.851 NM_001134445
DDAH1
dimethylarginine dimethylaminohydrolase 1
chr3_-_78666943 0.832 ROBO1
roundabout, axon guidance receptor, homolog 1 (Drosophila)
chr10_-_70066594 0.819 PBLD
phenazine biosynthesis-like protein domain containing
chr19_-_10426673 0.819 NM_001031734
FDX1L
ferredoxin 1-like
chr21_+_33784751 0.814 NM_058187
C21orf63
chromosome 21 open reading frame 63
chr14_-_61748510 0.814 NM_001017970
TMEM30B
transmembrane protein 30B
chr18_-_40857245 0.808 NM_020783
SYT4
synaptotagmin IV
chr17_-_2966900 0.802 NM_014566
OR1D5
olfactory receptor, family 1, subfamily D, member 5
chr9_+_100263461 0.788 NM_001166116
TMOD1
tropomodulin 1
chr6_-_49604524 0.779 NM_000324
RHAG
Rh-associated glycoprotein
chr13_+_32313678 0.778 NM_001166058
NM_130806
RXFP2

relaxin/insulin-like family peptide receptor 2

chr5_+_54320083 0.772 NM_002104
GZMK
granzyme K (granzyme 3; tryptase II)
chr6_+_7402879 0.769 NM_153005
RIOK1
RIO kinase 1 (yeast)
chr10_-_21186530 0.766 NM_006393
NEBL
nebulette
chr1_+_50571963 0.760 NM_001144775
ELAVL4
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)
chr1_-_182357757 0.758 GLUL
glutamate-ammonia ligase
chr1_-_226926875 0.755 NM_002221
ITPKB
inositol-trisphosphate 3-kinase B
chr12_-_58165877 0.743 NM_005371
NM_023033
METTL1

methyltransferase like 1

chr16_+_1728290 0.730 HN1L
hematological and neurological expressed 1-like
chr17_-_2996289 0.715 NM_002548
OR1D2
olfactory receptor, family 1, subfamily D, member 2
chr10_+_91061705 0.713 NM_001547
IFIT2
interferon-induced protein with tetratricopeptide repeats 2
chr6_-_136847609 0.711 MAP7
microtubule-associated protein 7
chr20_-_45061554 0.710 ELMO2
engulfment and cell motility 2
chr7_-_122339186 0.700 NM_139175
RNF133
ring finger protein 133
chr12_-_105322056 0.698 NM_032148
SLC41A2
solute carrier family 41, member 2
chr12_+_10331556 0.643 NM_153022
C12orf59
chromosome 12 open reading frame 59
chr4_+_119948554 0.631 SYNPO2
synaptopodin 2
chr8_+_32504250 0.626 NM_013959
NRG1
neuregulin 1
chr5_-_150467220 0.626 NM_001252390
TNIP1
TNFAIP3 interacting protein 1
chr20_-_18477811 0.624 NM_006606
RBBP9
retinoblastoma binding protein 9
chr4_+_169013687 0.609 NM_007193
ANXA10
annexin A10
chr3_-_138478184 0.602 NM_006219
PIK3CB
phosphoinositide-3-kinase, catalytic, beta polypeptide
chr18_-_31628557 0.597 NM_001198549
NOL4
nucleolar protein 4
chr6_-_90024936 0.588 NM_002043
GABRR2
gamma-aminobutyric acid (GABA) receptor, rho 2
chr7_-_108142934 0.579 PNPLA8
patatin-like phospholipase domain containing 8
chr8_+_1952875 0.574 KBTBD11
kelch repeat and BTB (POZ) domain containing 11
chr4_+_70796798 0.573 NM_001025104
NM_001890
CSN1S1

casein alpha s1

chr12_+_93096618 0.561 NM_001037671
NM_001178097
C12orf74

chromosome 12 open reading frame 74

chr1_-_231005334 0.560 NM_001136494
C1orf198
chromosome 1 open reading frame 198
chr5_+_140739589 0.556 NM_018923
NM_032096
PCDHGB2

protocadherin gamma subfamily B, 2

chr18_+_616671 0.553 NM_199167
CLUL1
clusterin-like 1 (retinal)
chr5_+_140792507 0.542 NM_018913
NM_032090
PCDHGA10

protocadherin gamma subfamily A, 10

chr5_-_94417185 0.530 MCTP1
multiple C2 domains, transmembrane 1
chr13_-_41556188 0.527 ELF1
E74-like factor 1 (ets domain transcription factor)
chr17_-_19290471 0.524 NM_001198695
NM_002404
MFAP4

microfibrillar-associated protein 4

chr1_-_204135420 0.519 NM_000537
REN
renin
chr11_+_111126706 0.509 NM_198498
C11orf53
chromosome 11 open reading frame 53
chr2_-_163099877 0.509 NM_004460
FAP
fibroblast activation protein, alpha
chr16_+_69680959 0.507 NFAT5
nuclear factor of activated T-cells 5, tonicity-responsive
chr6_-_114384008 0.502 NM_153612
HS3ST5
heparan sulfate (glucosamine) 3-O-sulfotransferase 5
chr21_+_27011588 0.499 NM_021219
JAM2
junctional adhesion molecule 2
chr12_-_9913415 0.498 NM_001781
CD69
CD69 molecule
chrX_+_103031797 0.491 PLP1
proteolipid protein 1
chr20_-_30539725 0.491 PDRG1
p53 and DNA-damage regulated 1
chr2_+_166095911 0.480 NM_001040142
SCN2A
sodium channel, voltage-gated, type II, alpha subunit
chr9_+_105757592 0.480 NM_001340
CYLC2
cylicin, basic protein of sperm head cytoskeleton 2
chr18_+_63417487 0.476 NM_033646
CDH7
cadherin 7, type 2
chr16_+_57673206 0.470 NM_001145774
GPR56
G protein-coupled receptor 56
chr21_-_36421586 0.468 NM_001754
RUNX1
runt-related transcription factor 1
chr13_+_97928414 0.459 MBNL2
muscleblind-like 2 (Drosophila)
chr4_+_95376396 0.459 PDLIM5
PDZ and LIM domain 5
chr10_+_225932 0.444 NM_001202467
NM_001202468
ZMYND11

zinc finger, MYND-type containing 11

chr5_-_137848517 0.442 ETF1
eukaryotic translation termination factor 1
chr7_+_28338939 0.441 NM_182899
CREB5
cAMP responsive element binding protein 5
chrM_+_12283 0.440


chrX_+_99839789 0.435 NM_022144
TNMD
tenomodulin
chr15_+_42066690 0.433 MAPKBP1
mitogen-activated protein kinase binding protein 1
chr5_-_98262217 0.432 NM_001270
CHD1
chromodomain helicase DNA binding protein 1
chr3_+_63884074 0.432 NM_001177387
ATXN7
ataxin 7
chr10_+_49609641 0.429 NM_002750
NM_139046
NM_139047
NM_139049
MAPK8



mitogen-activated protein kinase 8



chr13_-_41556360 0.428 NM_001145353
ELF1
E74-like factor 1 (ets domain transcription factor)
chr5_+_149887673 0.423 NM_001543
NDST1
N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1
chrX_+_83116153 0.421 NM_021118
CYLC1
cylicin, basic protein of sperm head cytoskeleton 1
chr1_-_205325915 0.421 NM_018203
KLHDC8A
kelch domain containing 8A
chr6_-_55740387 0.420 BMP5
bone morphogenetic protein 5
chr3_-_93747453 0.417 NM_001001850
STX19
syntaxin 19
chr12_-_53600999 0.413 NM_000889
ITGB7
integrin, beta 7
chr17_+_56315786 0.411 NM_001160102
NM_006151
LPO

lactoperoxidase

chrX_-_48056198 0.411 NM_021015
NM_175723
SSX5

synovial sarcoma, X breakpoint 5

chr2_+_183608329 0.409 DNAJC10
DnaJ (Hsp40) homolog, subfamily C, member 10
chr17_+_32582295 0.409 NM_002982
CCL2
chemokine (C-C motif) ligand 2
chr11_+_33363104 0.409 HIPK3
homeodomain interacting protein kinase 3
chr16_+_1728256 0.404 NM_144570
HN1L
hematological and neurological expressed 1-like
chr1_-_182357871 0.403 GLUL
glutamate-ammonia ligase
chr3_+_97158453 0.398 NM_173655
EPHA6
EPH receptor A6
chr5_-_160279045 0.397 NM_025153
ATP10B
ATPase, class V, type 10B
chr19_-_44174497 0.396 NM_001005376
NM_001005377
NM_002659
PLAUR


plasminogen activator, urokinase receptor


chr4_+_62362838 0.393 NM_015236
LPHN3
latrophilin 3
chrX_+_103031753 0.392 NM_000533
NM_199478
PLP1

proteolipid protein 1

chr4_-_153273683 0.387 NM_018315
FBXW7
F-box and WD repeat domain containing 7
chr11_-_57335756 0.384 NM_198183
UBE2L6
ubiquitin-conjugating enzyme E2L 6
chr15_+_49715374 0.382 NM_002009
FGF7
fibroblast growth factor 7
chr4_+_39063851 0.381 NM_015990
NM_199039
KLHL5

kelch-like 5 (Drosophila)

chr10_-_69455926 0.378 NM_013266
CTNNA3
catenin (cadherin-associated protein), alpha 3
chr11_-_13517525 0.377 NM_000315
PTH
parathyroid hormone
chr3_+_178276487 0.375 NM_005832
KCNMB2
potassium large conductance calcium-activated channel, subfamily M, beta member 2
chr12_-_46633551 0.373 SLC38A1
solute carrier family 38, member 1
chr5_-_132200476 0.372 NM_005260
GDF9
growth differentiation factor 9
chr13_-_38172862 0.370 NM_001135934
NM_001135935
NM_001135936
NM_006475
POSTN



periostin, osteoblast specific factor



chr6_-_13295817 0.368 NM_001242698
LOC100130357
uncharacterized LOC100130357
chr6_-_136847078 0.368 NM_001198608
NM_001198609
NM_001198611
MAP7


microtubule-associated protein 7


chr4_+_155484131 0.367 NM_001184741
NM_005141
FGB

fibrinogen beta chain

chr10_+_91152321 0.365 NM_001548
IFIT1
interferon-induced protein with tetratricopeptide repeats 1
chr5_-_95748688 0.365 NM_001177876
PCSK1
proprotein convertase subtilisin/kexin type 1
chr5_+_143191725 0.362 NM_021182
HMHB1
histocompatibility (minor) HB-1
chr3_+_171561138 0.360 NM_001164436
TMEM212
transmembrane protein 212
chr3_+_42190736 0.357 TRAK1
trafficking protein, kinesin binding 1
chr11_+_55650772 0.356 NM_032681
SPRYD5
SPRY domain containing 5
chr11_+_113845796 0.353 NM_000869
NM_213621
HTR3A

5-hydroxytryptamine (serotonin) receptor 3A

chr7_+_28475233 0.351 NM_004904
CREB5
cAMP responsive element binding protein 5
chr3_+_35721115 0.351 NM_001025068
NM_001025069
ARPP21

cAMP-regulated phosphoprotein, 21kDa

chr16_-_47005339 0.349 DNAJA2
DnaJ (Hsp40) homolog, subfamily A, member 2
chr7_+_29519485 0.349 NM_001039936
CHN2
chimerin (chimaerin) 2
chr5_-_27038650 0.342 NM_016279
CDH9
cadherin 9, type 2 (T1-cadherin)
chr11_-_85430117 0.341 NM_206929
SYTL2
synaptotagmin-like 2
chr10_-_74114865 0.340 NM_001002762
NM_017626
DNAJB12

DnaJ (Hsp40) homolog, subfamily B, member 12

chr2_+_108994366 0.336 NM_006588
SULT1C4
sulfotransferase family, cytosolic, 1C, member 4
chr3_-_123339423 0.335 NM_053031
NM_053032
MYLK

myosin light chain kinase

chr8_-_26724748 0.334 ADRA1A
adrenergic, alpha-1A-, receptor
chr1_+_86934525 0.331 NM_001285
CLCA1
chloride channel accessory 1
chr12_+_18414473 0.327 NM_004570
PIK3C2G
phosphoinositide-3-kinase, class 2, gamma polypeptide
chr5_+_140800536 0.325 NM_018914
NM_032091
NM_032092
PCDHGA11


protocadherin gamma subfamily A, 11


chr4_+_100432160 0.324 NM_032149
C4orf17
chromosome 4 open reading frame 17
chrX_+_78003205 0.323 NM_005296
LPAR4
lysophosphatidic acid receptor 4
chr2_+_27799388 0.323 NM_032266
C2orf16
chromosome 2 open reading frame 16
chr13_+_97794050 0.321 MBNL2
muscleblind-like 2 (Drosophila)
chr20_-_1974393 0.318 NM_001190900
PDYN
prodynorphin
chr11_+_27062508 0.317 NM_003986
BBOX1
butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1
chr13_-_110802708 0.316 COL4A1
collagen, type IV, alpha 1
chr14_-_101036130 0.310 NM_020836
BEGAIN
brain-enriched guanylate kinase-associated homolog (rat)
chr5_+_94727047 0.309 NM_152548
FAM81B
family with sequence similarity 81, member B
chrX_+_85517970 0.309 NM_001139515
DACH2
dachshund homolog 2 (Drosophila)
chr12_-_21487831 0.308 NM_021094
SLCO1A2
solute carrier organic anion transporter family, member 1A2
chr21_+_25801042 0.306 FLJ42200
FLJ42200 protein
chr4_+_108814419 0.306 NM_001136257
NM_152621
SGMS2

sphingomyelin synthase 2

chr1_+_171481164 0.306 PRRC2C
proline-rich coiled-coil 2C
chr1_-_32281577 0.305 NM_144569
SPOCD1
SPOC domain containing 1
chr15_+_54305100 0.305 NM_001080534
UNC13C
unc-13 homolog C (C. elegans)
chr12_-_45307710 0.305 NM_001145110
NELL2
NEL-like 2 (chicken)
chr4_+_15341559 0.302 NM_001135170
C1QTNF7
C1q and tumor necrosis factor related protein 7
chr7_+_18535817 0.301 NM_058176
NM_178425
HDAC9

histone deacetylase 9

chr5_+_140771482 0.301 NM_014004
NM_032088
PCDHGA8

protocadherin gamma subfamily A, 8

chr2_+_183989082 0.299 NM_138285
NUP35
nucleoporin 35kDa
chrX_-_15683153 0.299 NM_020665
TMEM27
transmembrane protein 27
chr22_-_36236421 0.297 NM_001031695
NM_001082576
NM_001082577
NM_014309
RBFOX2



RNA binding protein, fox-1 homolog (C. elegans) 2



chr7_+_142880511 0.296 NM_176881
TAS2R39
taste receptor, type 2, member 39
chr2_+_169757749 0.294 NM_001081686
NM_021176
G6PC2

glucose-6-phosphatase, catalytic, 2

chr11_-_101000457 0.293 NM_000926
PGR
progesterone receptor
chr14_+_70236266 0.290 SRSF5
serine/arginine-rich splicing factor 5
chr5_+_126859157 0.289 PRRC1
proline-rich coiled-coil 1
chr19_-_4540035 0.289 NM_052972
LRG1
leucine-rich alpha-2-glycoprotein 1
chr2_-_27632522 0.286 PPM1G
protein phosphatase, Mg2+/Mn2+ dependent, 1G
chr3_-_57234279 0.285 NM_003865
HESX1
HESX homeobox 1
chr3_-_167371288 0.284 NM_178824
WDR49
WD repeat domain 49
chr15_+_42066631 0.281 NM_001128608
NM_014994
MAPKBP1

mitogen-activated protein kinase binding protein 1

chr6_-_55740358 0.280 NM_021073
BMP5
bone morphogenetic protein 5
chr16_+_1728283 0.279 HN1L
hematological and neurological expressed 1-like
chr2_-_180610768 0.276 NM_001113397
ZNF385B
zinc finger protein 385B
chrX_+_144908927 0.274 NM_004709
CXorf1
chromosome X open reading frame 1
chr5_+_141346401 0.272 NM_001201365
NM_183399
RNF14

ring finger protein 14

chr6_+_29274402 0.272 NM_030946
OR14J1
olfactory receptor, family 14, subfamily J, member 1
chr12_-_56236614 0.270 NM_002429
MMP19
matrix metallopeptidase 19
chr12_-_87232635 0.269 NM_013244
MGAT4C
mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme C (putative)
chr6_-_10415438 0.269 NM_003220
TFAP2A
transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
chr9_-_112191105 0.269 NM_001145371
NM_001145372
PTPN3

protein tyrosine phosphatase, non-receptor type 3


Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.27 4.07e-04 GO:0050896 response to stimulus
1.35 6.12e-03 GO:0023052 signaling
1.33 7.21e-03 GO:0051716 cellular response to stimulus
1.36 1.28e-02 GO:0007165 signal transduction
1.26 1.42e-02 GO:0032501 multicellular organismal process
1.18 1.85e-02 GO:0065007 biological regulation

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.66 1.06e-06 GO:0005576 extracellular region
1.92 1.26e-05 GO:0044421 extracellular region part
1.83 3.52e-03 GO:0005615 extracellular space
2.23 2.56e-02 GO:0005578 proteinaceous extracellular matrix
1.26 2.98e-02 GO:0071944 cell periphery
1.39 3.49e-02 GO:0044459 plasma membrane part

Gene overrepresentation in function category:

enrichment   p-value GO term description
5.25 4.42e-02 GO:0003823 antigen binding