Motif ID: CEBPA,B_DDIT3.p2

Z-value: 1.060


Transcription factors associated with CEBPA,B_DDIT3.p2:

Gene SymbolEntrez IDGene Name
CEBPA 1050 CCAAT/enhancer binding protein (C/EBP), alpha
CEBPB 1051 CCAAT/enhancer binding protein (C/EBP), beta
DDIT3 1649 DNA-damage-inducible transcript 3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.p-valuePlot
CEBPBchr20_+_488073650.433.1e-02Click!
DDIT3chr12_-_579142870.331.1e-01Click!
CEBPAchr19_-_33793429-0.183.9e-01Click!


Activity profile for motif CEBPA,B_DDIT3.p2.

activity profile for motif CEBPA,B_DDIT3.p2


Sorted Z-values histogram for motif CEBPA,B_DDIT3.p2

Sorted Z-values for motif CEBPA,B_DDIT3.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of CEBPA,B_DDIT3.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr11_-_8739398 4.953 ST5
suppression of tumorigenicity 5
chr21_+_43619798 3.541 NM_207627
NM_207628
ABCG1

ATP-binding cassette, sub-family G (WHITE), member 1

chrX_+_9431314 2.679 NM_001139466
NM_001139467
NM_001139468
TBL1X


transducin (beta)-like 1X-linked


chr15_+_89182038 2.115 NM_002201
ISG20
interferon stimulated exonuclease gene 20kDa
chr6_+_80340971 1.934 NM_031469
SH3BGRL2
SH3 domain binding glutamic acid-rich protein like 2
chr3_-_79817058 1.849 NM_002941
ROBO1
roundabout, axon guidance receptor, homolog 1 (Drosophila)
chr6_-_29527477 1.654 UBD
ubiquitin D
chr16_+_56966025 1.519 HERPUD1
homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
chr11_-_104972147 1.499 NM_001007232
NM_001223
NM_033292
NM_033293
NM_033294
NM_033295
CARD17
CASP1




caspase recruitment domain family, member 17
caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)




chr11_-_102668892 1.494 NM_001145938
NM_002421
MMP1

matrix metallopeptidase 1 (interstitial collagenase)

chr5_+_125758818 1.486 NM_001146320
NM_001146321
NM_023927
GRAMD3


GRAM domain containing 3


chr2_+_234296799 1.394 NM_003648
DGKD
diacylglycerol kinase, delta 130kDa
chr18_+_61637262 1.393 NM_001031848
NM_002640
NM_198833
SERPINB8


serpin peptidase inhibitor, clade B (ovalbumin), member 8


chr1_-_173020011 1.361 NM_005092
TNFSF18
tumor necrosis factor (ligand) superfamily, member 18
chr17_-_55980749 1.277 NM_017949
CUEDC1
CUE domain containing 1
chr15_-_55563091 1.269 NM_183236
RAB27A
RAB27A, member RAS oncogene family
chr19_+_1450208 1.208 APC2
adenomatosis polyposis coli 2
chrX_+_144908927 1.198 NM_004709
CXorf1
chromosome X open reading frame 1
chr12_-_53074172 1.195 NM_006121
KRT1
keratin 1
chr5_+_154135029 1.185 LARP1
La ribonucleoprotein domain family, member 1
chr12_-_121736110 1.145 NM_006549
NM_153499
NM_153500
NM_172214
NM_172215
NM_172216
CAMKK2





calcium/calmodulin-dependent protein kinase kinase 2, beta





chrX_-_40506666 1.114 CXorf38
chromosome X open reading frame 38
chr6_+_12717036 1.002 NM_001242648
NM_030948
PHACTR1

phosphatase and actin regulator 1

chr19_-_44174497 0.998 NM_001005376
NM_001005377
NM_002659
PLAUR


plasminogen activator, urokinase receptor


chr17_-_34207308 0.969 NM_002985
CCL5
chemokine (C-C motif) ligand 5
chr5_-_24645084 0.931 NM_006727
CDH10
cadherin 10, type 2 (T2-cadherin)
chrX_-_40506800 0.905 NM_144970
CXorf38
chromosome X open reading frame 38
chr15_+_67430358 0.902 NM_001145103
SMAD3
SMAD family member 3
chr13_-_30169584 0.900 SLC7A1
solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
chr1_-_153521717 0.891 NM_002960
S100A3
S100 calcium binding protein A3
chr5_-_16738346 0.869 MYO10
myosin X
chr3_+_130569368 0.815 NM_001199180
NM_001199181
NM_001199182
ATP2C1


ATPase, Ca++ transporting, type 2C, member 1


chr5_-_94224601 0.806 MCTP1
multiple C2 domains, transmembrane 1
chr10_-_92680784 0.804 ANKRD1
ankyrin repeat domain 1 (cardiac muscle)
chr7_-_83824216 0.799 NM_006080
SEMA3A
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A
chr9_-_77503009 0.766 NM_017662
TRPM6
transient receptor potential cation channel, subfamily M, member 6
chr15_+_41245635 0.744 NM_001142776
NM_024111
CHAC1

ChaC, cation transport regulator homolog 1 (E. coli)

chr9_+_80911990 0.721 NM_021154
NM_058179
PSAT1

phosphoserine aminotransferase 1

chr1_-_23342342 0.720 NM_001242521
LOC729059
uncharacterized LOC729059
chr19_-_35992798 0.697 NM_001035516
DMKN
dermokine
chr3_-_42843217 0.689


chr2_-_29297126 0.683 NM_001029883
C2orf71
chromosome 2 open reading frame 71
chr11_-_102668822 0.679 MMP1
matrix metallopeptidase 1 (interstitial collagenase)
chr1_-_20250051 0.656 NM_014589
PLA2G2E
phospholipase A2, group IIE
chr19_-_47735858 0.653 NM_001127240
NM_001127241
NM_001127242
BBC3


BCL2 binding component 3


chr17_+_56315786 0.648 NM_001160102
NM_006151
LPO

lactoperoxidase

chr7_+_28338939 0.626 NM_182899
CREB5
cAMP responsive element binding protein 5
chr4_+_108814419 0.608 NM_001136257
NM_152621
SGMS2

sphingomyelin synthase 2

chr10_-_92681025 0.606 NM_014391
ANKRD1
ankyrin repeat domain 1 (cardiac muscle)
chr9_-_77502262 0.605 NM_001177311
TRPM6
transient receptor potential cation channel, subfamily M, member 6
chr5_-_131630939 0.601


chr5_+_131409484 0.580 NM_000758
CSF2
colony stimulating factor 2 (granulocyte-macrophage)
chr11_-_8832881 0.573 NM_139157
ST5
suppression of tumorigenicity 5
chr6_+_167704802 0.564 NM_001143947
NM_018974
UNC93A

unc-93 homolog A (C. elegans)

chr12_-_63328857 0.562 PPM1H
protein phosphatase, Mg2+/Mn2+ dependent, 1H
chr5_-_16742336 0.552 MYO10
myosin X
chr2_-_74542149 0.549 NM_021196
SLC4A5
solute carrier family 4, sodium bicarbonate cotransporter, member 5
chr14_+_103592663 0.536 NM_006291
TNFAIP2
tumor necrosis factor, alpha-induced protein 2
chr9_-_95055913 0.535 IARS
isoleucyl-tRNA synthetase
chr19_+_44084695 0.533 NM_001193622
LOC390940
uncharacterized protein ENSP00000244321
chr7_-_104567089 0.532 LOC723809
uncharacterized LOC723809
chr20_+_68312 0.531 NM_153325
DEFB125
defensin, beta 125
chr10_+_91087601 0.523 NM_001549
IFIT3
interferon-induced protein with tetratricopeptide repeats 3
chr3_+_1134619 0.512 NM_014461
CNTN6
contactin 6
chr15_-_64126081 0.511 HERC1
hect (homologous to the E6-AP (UBE3A) carboxyl terminus) domain and RCC1 (CHC1)-like domain (RLD) 1
chr15_-_72598655 0.511 NM_001172685
CELF6
CUGBP, Elav-like family member 6
chr12_+_54426831 0.502 NM_018953
HOXC5
homeobox C5
chr9_+_5510544 0.500 NM_025239
PDCD1LG2
programmed cell death 1 ligand 2
chr9_-_95055966 0.492 NM_013417
IARS
isoleucyl-tRNA synthetase
chr9_-_95055989 0.479 NM_002161
IARS
isoleucyl-tRNA synthetase
chr14_+_32798478 0.478 NM_004274
AKAP6
A kinase (PRKA) anchor protein 6
chr12_-_49259549 0.476 NM_014470
RND1
Rho family GTPase 1
chr9_-_95055986 0.469 IARS
isoleucyl-tRNA synthetase
chr17_+_41158741 0.468 NM_005533
IFI35
interferon-induced protein 35
chr8_+_118147336 0.467 NM_001172814
NM_173851
SLC30A8

solute carrier family 30 (zinc transporter), member 8

chr6_+_158734902 0.465


chr17_-_64225496 0.454 NM_000042
APOH
apolipoprotein H (beta-2-glycoprotein I)
chr3_+_136676706 0.453 NM_144717
IL20RB
interleukin 20 receptor beta
chr2_+_169757749 0.443 NM_001081686
NM_021176
G6PC2

glucose-6-phosphatase, catalytic, 2

chr9_-_114247024 0.443 NM_001080398
KIAA0368
KIAA0368
chr12_-_52867521 0.435 NM_173086
KRT6C
keratin 6C
chr12_-_53045947 0.429 NM_000423
KRT2
keratin 2
chr8_+_24151579 0.423 NM_014265
NM_021777
ADAM28

ADAM metallopeptidase domain 28

chr1_+_212782103 0.423 ATF3
activating transcription factor 3
chr9_-_77502635 0.411 NM_001177310
TRPM6
transient receptor potential cation channel, subfamily M, member 6
chr12_+_109967734 0.409 UBE3B
ubiquitin protein ligase E3B
chr16_+_3405888 0.408 NM_012368
OR2C1
olfactory receptor, family 2, subfamily C, member 1
chr3_+_186739643 0.403 NM_003032
ST6GAL1
ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
chr15_-_64126133 0.403 NM_003922
HERC1
hect (homologous to the E6-AP (UBE3A) carboxyl terminus) domain and RCC1 (CHC1)-like domain (RLD) 1
chr6_-_37225360 0.399 NM_145316
TMEM217
transmembrane protein 217
chr5_-_66492574 0.397 NM_005582
CD180
CD180 molecule
chr11_-_104905849 0.396 CASP1
caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)
chr16_-_70323407 0.394 NM_001605
AARS
alanyl-tRNA synthetase
chr2_+_237478379 0.392 NM_020311
CXCR7
chemokine (C-X-C motif) receptor 7
chr16_-_70323343 0.388 AARS
alanyl-tRNA synthetase
chr22_+_23054862 0.387 IGLV3-21
IGLJ3
IGLC1
immunoglobulin lambda variable 3-21
immunoglobulin lambda joining 3
immunoglobulin lambda constant 1 (Mcg marker)
chr19_+_49078992 0.386 NM_004605
SULT2B1
sulfotransferase family, cytosolic, 2B, member 1
chr12_-_122296619 0.385 NM_002150
HPD
4-hydroxyphenylpyruvate dioxygenase
chr20_+_361938 0.383 TRIB3
tribbles homolog 3 (Drosophila)
chr17_-_39092714 0.377 KRT23
keratin 23 (histone deacetylase inducible)
chr2_+_108994366 0.377 NM_006588
SULT1C4
sulfotransferase family, cytosolic, 1C, member 4
chr20_+_57766074 0.375 NM_178457
ZNF831
zinc finger protein 831
chr17_-_38978824 0.371 NM_000421
KRT10
keratin 10
chr5_+_125759076 0.362 GRAMD3
GRAM domain containing 3
chr11_-_69519105 0.356 NM_005117
FGF19
fibroblast growth factor 19
chr9_+_137004913 0.340 NM_052821
WDR5
WD repeat domain 5
chr19_+_6887576 0.340 NM_001974
EMR1
egf-like module containing, mucin-like, hormone receptor-like 1
chr6_+_126240369 0.337 NM_001199622
NCOA7
nuclear receptor coactivator 7
chr7_-_138363789 0.334 NM_001139456
SVOPL
SVOP-like
chr2_+_68872953 0.334 NM_138964
PROKR1
prokineticin receptor 1
chr1_+_20396652 0.331 NM_000929
PLA2G5
phospholipase A2, group V
chr17_-_32690180 0.330 NM_002981
CCL1
chemokine (C-C motif) ligand 1
chr19_+_33864574 0.329 NM_001806
CEBPG
CCAAT/enhancer binding protein (C/EBP), gamma
chr8_+_123793988 0.326 ZHX2
zinc fingers and homeoboxes 2
chr11_+_71846755 0.325 NM_000804
FOLR3
folate receptor 3 (gamma)
chr8_+_32504250 0.318 NM_013959
NRG1
neuregulin 1
chr18_-_40857245 0.314 NM_020783
SYT4
synaptotagmin IV
chr18_+_72167021 0.311 CNDP2
CNDP dipeptidase 2 (metallopeptidase M20 family)
chr1_-_1711453 0.309 NM_001198994
NADK
NAD kinase
chr17_-_56492938 0.308 RNF43
ring finger protein 43
chr14_+_74083547 0.306 NM_001037162
ACOT6
acyl-CoA thioesterase 6
chr14_-_89016806 0.306 PTPN21
protein tyrosine phosphatase, non-receptor type 21
chr22_-_36635999 0.305 NM_145637
APOL2
apolipoprotein L, 2
chr1_-_230513390 0.300 NM_024554
PGBD5
piggyBac transposable element derived 5
chr1_-_21501229 0.299 NM_001198803
EIF4G3
eukaryotic translation initiation factor 4 gamma, 3
chr12_-_10151689 0.299 NM_001099431
NM_016509
CLEC1B

C-type lectin domain family 1, member B

chr16_-_84651519 0.297 COTL1
coactosin-like 1 (Dictyostelium)
chr16_-_84651639 0.295 NM_021149
COTL1
coactosin-like 1 (Dictyostelium)
chr17_-_7578810 0.292 NM_001126115
NM_001126116
NM_001126117
TP53


tumor protein p53


chr11_+_67777788 0.289 NM_000694
NM_001030010
ALDH3B1

aldehyde dehydrogenase 3 family, member B1

chr3_+_132036276 0.286 ACPP
acid phosphatase, prostate
chr5_-_138862224 0.283 TMEM173
transmembrane protein 173
chr15_+_85923739 0.281 NM_006738
NM_007200
AKAP13

A kinase (PRKA) anchor protein 13

chr19_+_44084758 0.281 LOC390940
uncharacterized protein ENSP00000244321
chr2_+_113825546 0.279 NM_173161
IL1F10
interleukin 1 family, member 10 (theta)
chr14_+_35514112 0.276 NM_001079519
FAM177A1
family with sequence similarity 177, member A1
chr16_+_24266873 0.276 NM_006539
CACNG3
calcium channel, voltage-dependent, gamma subunit 3
chr1_+_212781969 0.276 NM_001040619
NM_001206484
NM_001206488
NM_001674
ATF3



activating transcription factor 3



chr7_+_28725597 0.274 NM_001011666
CREB5
cAMP responsive element binding protein 5
chr10_+_86004808 0.272 NM_001012720
NM_001012722
NM_002921
RGR


retinal G protein coupled receptor


chr8_-_27115935 0.270 STMN4
stathmin-like 4
chr21_+_30400229 0.265 USP16
ubiquitin specific peptidase 16
chr8_+_124194873 0.263 FAM83A
family with sequence similarity 83, member A
chr16_+_56815703 0.263 NM_001242795
NUP93
nucleoporin 93kDa
chr18_+_72166568 0.262 CNDP2
CNDP dipeptidase 2 (metallopeptidase M20 family)
chr3_+_157154579 0.261 NM_002852
PTX3
pentraxin 3, long
chr9_+_116342939 0.259 NM_021106
RGS3
regulator of G-protein signaling 3
chr9_+_110045516 0.256 NM_002874
RAD23B
RAD23 homolog B (S. cerevisiae)
chr4_+_77870864 0.256 NM_018243
SEPT11
septin 11
chr3_-_150920946 0.254 NM_013308
GPR171
G protein-coupled receptor 171
chr14_+_62462540 0.254 NM_031914
SYT16
synaptotagmin XVI
chr3_+_32993065 0.251 NM_005508
CCR4
chemokine (C-C motif) receptor 4
chr17_+_1665306 0.250 SERPINF1
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
chr20_+_34995443 0.249 NM_014902
DLGAP4
discs, large (Drosophila) homolog-associated protein 4
chr5_-_138862342 0.247 NM_198282
TMEM173
transmembrane protein 173
chr11_+_55650772 0.247 NM_032681
SPRYD5
SPRY domain containing 5
chr4_-_70826712 0.246 NM_001891
CSN2
casein beta
chr9_-_95186559 0.246 NM_005014
OMD
osteomodulin
chr10_-_79789290 0.245 NM_007055
POLR3A
polymerase (RNA) III (DNA directed) polypeptide A, 155kDa
chr6_+_36644236 0.235 NM_001220777
NM_078467
CDKN1A

cyclin-dependent kinase inhibitor 1A (p21, Cip1)

chr3_+_9476506 0.234


chr5_+_140734767 0.233 NM_018917
NM_032053
PCDHGA4

protocadherin gamma subfamily A, 4

chr6_+_31913852 0.233 CFB
complement factor B
chr17_-_49124128 0.231 NM_001251971
SPAG9
sperm associated antigen 9
chr19_-_4302381 0.227 NM_001169126
NM_144615
TMIGD2

transmembrane and immunoglobulin domain containing 2

chr17_-_30228715 0.226 NM_018428
UTP6
UTP6, small subunit (SSU) processome component, homolog (yeast)
chr7_-_47988036 0.225 NM_138295
PKD1L1
polycystic kidney disease 1 like 1
chr3_+_127641901 0.224 NM_207335
KBTBD12
kelch repeat and BTB (POZ) domain containing 12
chr8_+_26435590 0.221 DPYSL2
dihydropyrimidinase-like 2
chr17_-_10633645 0.219 NM_001004313
TMEM220
transmembrane protein 220
chr12_-_54758228 0.218 NM_020370
GPR84
G protein-coupled receptor 84
chr19_+_44220213 0.217 NM_019612
IRGC
immunity-related GTPase family, cinema
chr17_+_33448597 0.217 NM_017559
FNDC8
fibronectin type III domain containing 8
chr19_-_49258646 0.213 NM_000148
FUT1
fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group)
chr5_+_140743755 0.212 NM_018918
NM_032054
PCDHGA5

protocadherin gamma subfamily A, 5

chr5_-_178017555 0.211 NM_173465
COL23A1
collagen, type XXIII, alpha 1
chr19_+_33865429 0.210 NM_001252296
CEBPG
CCAAT/enhancer binding protein (C/EBP), gamma
chr14_+_21359542 0.199 NM_002935
RNASE3
ribonuclease, RNase A family, 3
chr1_+_11249344 0.199 NM_021146
ANGPTL7
angiopoietin-like 7
chrX_+_96138906 0.197 NM_013347
RPA4
replication protein A4, 30kDa
chr6_+_31895201 0.197 NM_000063
NM_001145903
C2

complement component 2

chr13_+_27844463 0.197 NM_206827
RASL11A
RAS-like, family 11, member A
chr4_-_153273683 0.194 NM_018315
FBXW7
F-box and WD repeat domain containing 7
chr11_+_27015627 0.193 NM_203371
FIBIN
fin bud initiation factor homolog (zebrafish)
chr17_+_51900238 0.191 NM_032559
KIF2B
kinesin family member 2B
chr12_-_57914287 0.190 NM_001195053
NM_001195054
NM_001195055
NM_001195056
NM_001195057
NM_004083
DDIT3





DNA-damage-inducible transcript 3





chrX_+_15518899 0.189 NM_203281
BMX
BMX non-receptor tyrosine kinase
chr11_+_75428864 0.188 NM_025098
MOGAT2
monoacylglycerol O-acyltransferase 2
chr5_+_145583112 0.188 RBM27
RNA binding motif protein 27
chr16_+_56817367 0.183 NM_001242796
NUP93
nucleoporin 93kDa
chr17_-_30228633 0.181 UTP6
UTP6, small subunit (SSU) processome component, homolog (yeast)
chr22_-_43355886 0.180 NM_001184971
PACSIN2
protein kinase C and casein kinase substrate in neurons 2
chr3_-_112359962 0.180 NM_199511
NM_199512
CCDC80

coiled-coil domain containing 80

chr12_+_10331556 0.179 NM_153022
C12orf59
chromosome 12 open reading frame 59
chr4_+_184020343 0.178 NM_024949
WWC2
WW and C2 domain containing 2
chr4_-_71532341 0.176 NM_144646
IGJ
immunoglobulin J polypeptide, linker protein for immunoglobulin alpha and mu polypeptides
chr9_-_71590754 0.175


chr3_+_12392993 0.174 NM_015869
PPARG
peroxisome proliferator-activated receptor gamma
chr20_+_5987897 0.173 NM_001127458
CRLS1
cardiolipin synthase 1
chr4_-_69536314 0.172 NM_001076
UGT2B15
UDP glucuronosyltransferase 2 family, polypeptide B15

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
2.57 6.67e-06 GO:0006955 immune response
2.05 1.28e-04 GO:0002376 immune system process
2.47 7.68e-03 GO:0009607 response to biotic stimulus
3.31 7.75e-03 GO:0032101 regulation of response to external stimulus
2.00 4.35e-02 GO:0006952 defense response

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.87 2.13e-07 GO:0005576 extracellular region

Nothing significant found in function category.