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• Activity deltas table
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Motif ID: EOMES.p2

Z-value: 0.897

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Top targets:

Promoter	Score	Refseq	Gene Symbol	Gene Name
chr2_+_228678556	5.893	NM_001130046 NM_004591	CCL20	chemokine (C-C motif) ligand 20
chr1_-_205290756	4.631	NM_030952	NUAK2	NUAK family, SNF1-like kinase, 2
chr5_+_113698304	4.546		KCNN2	potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2
chr5_+_113698015	3.458	NM_021614	KCNN2	potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2
chr17_+_25958257	3.301		LGALS9	lectin, galactoside-binding, soluble, 9
chr17_+_25958245	3.269		LGALS9	lectin, galactoside-binding, soluble, 9
chr20_-_62199106	3.234	NM_033405	PRIC285	peroxisomal proliferator-activated receptor A interacting complex 285
chr19_+_10381763	3.215		ICAM1	intercellular adhesion molecule 1
chr17_-_20370819	3.214	NM_001042685	LGALS9B	lectin, galactoside-binding, soluble, 9B
chr12_+_124773709	3.151	NM_181709	FAM101A	family with sequence similarity 101, member A
chr1_+_212782103	2.690		ATF3	activating transcription factor 3
chr4_-_76957139	2.527	NM_005409	CXCL11	chemokine (C-X-C motif) ligand 11
chr14_+_55034633	2.454		SAMD4A	sterile alpha motif domain containing 4A
chr17_+_25958217	2.386		LGALS9	lectin, galactoside-binding, soluble, 9
chr17_+_25958192	2.292		LGALS9	lectin, galactoside-binding, soluble, 9
chr17_+_25958151	2.273	NM_002308 NM_009587	LGALS9	lectin, galactoside-binding, soluble, 9
chr5_+_35856990	2.254	NM_002185	IL7R	interleukin 7 receptor
chr1_+_212781969	2.199	NM_001040619 NM_001206484 NM_001206488 NM_001674	ATF3	activating transcription factor 3
chr19_-_17958773	2.122		JAK3	Janus kinase 3
chr5_+_125800786	2.114	NM_001146322	GRAMD3	GRAM domain containing 3
chr5_+_54320083	2.028	NM_002104	GZMK	granzyme K (granzyme 3; tryptase II)
chr15_-_72501017	1.717		PKM2	pyruvate kinase, muscle
chr10_+_114135965	1.684		ACSL5	acyl-CoA synthetase long-chain family member 5
chr5_-_35938736	1.630	NM_001042625 NM_144647	CAPSL	calcyphosine-like
chr6_+_36646455	1.391	NM_000389 NM_001220778	CDKN1A	cyclin-dependent kinase inhibitor 1A (p21, Cip1)
chr15_+_60296506	1.369		FOXB1	forkhead box B1
chr9_-_123676849	1.366	NM_001190947	TRAF1	TNF receptor-associated factor 1
chr15_+_60296420	1.362	NM_012182	FOXB1	forkhead box B1
chr4_+_8582216	1.334	NM_080819	GPR78	G protein-coupled receptor 78
chr1_+_28585959	1.275	NM_031459	SESN2	sestrin 2
chr2_+_171571800	1.273	NM_001003845	SP5	Sp5 transcription factor
chr12_-_322612	1.273	NM_003044 NM_001122847	SLC6A12	solute carrier family 6 (neurotransmitter transporter, betaine/GABA), member 12
chr17_+_18380097	1.193	NM_001040078	LGALS9B LGALS9C	lectin, galactoside-binding, soluble, 9B lectin, galactoside-binding, soluble, 9C
chr2_-_100758970	1.179	NM_002285	AFF3	AF4/FMR2 family, member 3
chr21_-_36421586	1.173	NM_001754	RUNX1	runt-related transcription factor 1
chr21_-_36421630	1.164		RUNX1	runt-related transcription factor 1
chr2_+_171572698	1.138		SP5	Sp5 transcription factor
chr14_+_55034329	1.124	NM_001161576 NM_015589	SAMD4A	sterile alpha motif domain containing 4A
chr12_-_49259549	1.111	NM_014470	RND1	Rho family GTPase 1
chr3_-_71542628	1.072		FOXP1	forkhead box P1
chrX_+_48336379	1.053	NM_177434	FTSJ1	FtsJ homolog 1 (E. coli)
chr2_-_225907312	1.050	NM_014689	DOCK10	dedicator of cytokinesis 10
chr10_+_114135937	1.046	NM_016234	ACSL5	acyl-CoA synthetase long-chain family member 5
chr17_+_42925278	1.046	NM_016438	HIGD1B	HIG1 hypoxia inducible domain family, member 1B
chr4_-_7436614	1.036	NM_001085382	PSAPL1	prosaposin-like 1 (gene/pseudogene)
chr11_-_111636995	1.035		PPP2R1B	protein phosphatase 2, regulatory subunit A, beta
chr2_-_113542970	1.034	NM_000575	IL1A	interleukin 1, alpha
chr4_-_170924911	1.003	NM_001009554	MFAP3L	microfibrillar-associated protein 3-like
chr2_+_102770401	0.997	NM_000877	IL1R1	interleukin 1 receptor, type I
chr5_-_16742336	0.966		MYO10	myosin X
chr5_+_96211643	0.962	NM_001130140 NM_022350	ERAP2	endoplasmic reticulum aminopeptidase 2
chr11_-_9225780	0.948		DENND5A	DENN/MADD domain containing 5A
chr15_+_66694216	0.927		MAP2K1	mitogen-activated protein kinase kinase 1
chr9_+_34990715	0.921		DNAJB5	DnaJ (Hsp40) homolog, subfamily B, member 5
chr10_+_114136014	0.920		ACSL5	acyl-CoA synthetase long-chain family member 5
chr9_+_34990266	0.896	NM_001135005	DNAJB5	DnaJ (Hsp40) homolog, subfamily B, member 5
chr1_-_26633110	0.890	NM_001077262 NM_183008	UBXN11	UBX domain protein 11
chr2_-_74753311	0.881	NM_133637	DQX1	DEAQ box RNA-dependent ATPase 1
chr10_-_92680784	0.875		ANKRD1	ankyrin repeat domain 1 (cardiac muscle)
chr6_-_13295817	0.872	NM_001242698	LOC100130357	uncharacterized LOC100130357
chr10_+_24498088	0.850		KIAA1217	KIAA1217
chr10_+_114154522	0.846		ACSL5	acyl-CoA synthetase long-chain family member 5
chr11_+_19734821	0.845	NM_001244963 NM_145117 NM_182964	NAV2	neuron navigator 2
chr14_+_95078713	0.812	NM_001085	SERPINA3	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
chr15_-_58306185	0.812	NM_170697	ALDH1A2	aldehyde dehydrogenase 1 family, member A2
chr20_+_55904814	0.811	NM_012444 NM_198265	SPO11	SPO11 meiotic protein covalently bound to DSB homolog (S. cerevisiae)
chr2_-_161130151	0.768		RBMS1	RNA binding motif, single stranded interacting protein 1
chr19_-_7990974	0.766	NM_206833	CTXN1	cortexin 1
chr17_+_8213555	0.754	NM_173728	ARHGEF15	Rho guanine nucleotide exchange factor (GEF) 15
chr6_-_46459710	0.743	NM_001251973	RCAN2	regulator of calcineurin 2
chrX_+_70443055	0.735	NM_000166	GJB1	gap junction protein, beta 1, 32kDa
chr2_-_26101091	0.705
chr15_-_58358120	0.697	NM_001206897 NM_003888 NM_170696	ALDH1A2	aldehyde dehydrogenase 1 family, member A2
chr17_+_46185125	0.695		SNX11	sorting nexin 11
chr10_+_24497719	0.695	NM_001098501 NM_019590	KIAA1217	KIAA1217
chr6_-_130536417	0.693	NM_152552	SAMD3	sterile alpha motif domain containing 3
chr3_-_66551341	0.691		LRIG1	leucine-rich repeats and immunoglobulin-like domains 1
chr10_+_114135013	0.686	NM_203380	ACSL5	acyl-CoA synthetase long-chain family member 5
chr14_+_51026742	0.672	NM_015915 NM_181598	ATL1	atlastin GTPase 1
chr10_+_70847817	0.662	NM_002727	SRGN	serglycin
chr5_+_150040402	0.659	NM_001122853 NM_133371	MYOZ3	myozenin 3
chr5_+_14664803	0.652		FAM105B	family with sequence similarity 105, member B
chr7_-_139763520	0.650	NM_022750	PARP12	poly (ADP-ribose) polymerase family, member 12
chr5_+_140749830	0.649	NM_018924 NM_032097	PCDHGB3	protocadherin gamma subfamily B, 3
chr3_-_133748727	0.646		SLCO2A1	solute carrier organic anion transporter family, member 2A1
chr6_-_46293628	0.645	NM_005822	RCAN2	regulator of calcineurin 2
chr21_+_27011766	0.642		JAM2	junctional adhesion molecule 2
chr2_-_152146373	0.641	NM_004688	NMI	N-myc (and STAT) interactor
chr21_+_27011588	0.639	NM_021219	JAM2	junctional adhesion molecule 2
chr6_-_90062439	0.638		UBE2J1	ubiquitin-conjugating enzyme E2, J1, U
chr17_-_10452939	0.631	NM_001100112 NM_017534	MYH2	myosin, heavy chain 2, skeletal muscle, adult
chr6_+_83073954	0.627	NM_001166392	TPBG	trophoblast glycoprotein
chr15_-_58357848	0.624		ALDH1A2	aldehyde dehydrogenase 1 family, member A2
chr6_-_90062289	0.615		UBE2J1	ubiquitin-conjugating enzyme E2, J1, U
chr1_+_184356364	0.610		C1orf21	chromosome 1 open reading frame 21
chr6_+_64281910	0.609	NM_003463	PTP4A1	protein tyrosine phosphatase type IVA, member 1
chr18_+_32073343	0.605		DTNA	dystrobrevin, alpha
chr11_-_7847518	0.605	NM_153445	OR5P3	olfactory receptor, family 5, subfamily P, member 3
chr2_-_16081703	0.604		MYCNOS	MYCN opposite strand/antisense RNA (non-protein coding)
chr6_+_30294620	0.599	NM_021253	TRIM39	tripartite motif containing 39
chr3_-_187463474	0.599	NM_001706	BCL6	B-cell CLL/lymphoma 6
chr13_-_30169795	0.594	NM_003045	SLC7A1	solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
chr10_-_75335415	0.594	NM_152586	USP54	ubiquitin specific peptidase 54
chr15_-_80263460	0.590	NM_001114735 NM_004049	BCL2A1	BCL2-related protein A1
chr6_-_90062349	0.587		UBE2J1	ubiquitin-conjugating enzyme E2, J1, U
chr13_+_109248499	0.587	NM_015011	MYO16	myosin XVI
chr1_+_46379258	0.581		MAST2	microtubule associated serine/threonine kinase 2
chrX_+_102862833	0.577	NM_001006933 NM_032926	TCEAL3	transcription elongation factor A (SII)-like 3
chr10_+_118305427	0.577	NM_000936	PNLIP	pancreatic lipase
chr2_+_69201704	0.576	NM_019617	GKN1	gastrokine 1
chr17_+_8214139	0.575	NM_025014	ARHGEF15	Rho guanine nucleotide exchange factor (GEF) 15
chr13_+_97928196	0.571		MBNL2	muscleblind-like 2 (Drosophila)
chr20_+_825284	0.567	NM_031424	FAM110A	family with sequence similarity 110, member A
chr21_+_25801042	0.560		FLJ42200	FLJ42200 protein
chr3_+_38347426	0.557	NM_004803	SLC22A14	solute carrier family 22, member 14
chr11_-_64703334	0.556	NM_130769	GPHA2	glycoprotein hormone alpha 2
chr14_+_51026853	0.554		ATL1	atlastin GTPase 1
chr11_-_111637085	0.550	NM_001177562 NM_001177563 NM_002716 NM_181699 NM_181700	PPP2R1B	protein phosphatase 2, regulatory subunit A, beta
chr2_+_16082148	0.548		MYCN	v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)
chr6_+_84562984	0.544	NM_001009994	RIPPLY2	ripply2 homolog (zebrafish)
chr6_-_29012951	0.538	NM_030903	OR2W1	olfactory receptor, family 2, subfamily W, member 1
chr3_-_133748828	0.536	NM_005630	SLCO2A1	solute carrier organic anion transporter family, member 2A1
chr19_+_36236460	0.535	NM_172341	PSENEN	presenilin enhancer 2 homolog (C. elegans)
chrX_-_154563735	0.534	NM_001289	CLIC2	chloride intracellular channel 2
chrX_+_16804531	0.531	NM_001168683 NM_018360	TXLNG	taxilin gamma
chr1_-_153521717	0.531	NM_002960	S100A3	S100 calcium binding protein A3
chr5_+_96212167	0.530		ERAP2	endoplasmic reticulum aminopeptidase 2
chr2_+_71295685	0.529		NAGK	N-acetylglucosamine kinase
chr6_+_30295007	0.526	NM_172016	TRIM39	tripartite motif containing 39
chr1_-_32281577	0.512	NM_144569	SPOCD1	SPOC domain containing 1
chr11_-_117698727	0.506	NM_021603	FXYD2	FXYD domain containing ion transport regulator 2
chr6_+_36922208	0.506	NM_153370	PI16	peptidase inhibitor 16
chr15_+_52311438	0.502		MAPK6	mitogen-activated protein kinase 6
chrM_+_9217	0.501
chr17_+_46184910	0.494	NM_152244 NM_013323	SNX11	sorting nexin 11
chr4_+_25235651	0.494	NM_018323	PI4K2B	phosphatidylinositol 4-kinase type 2 beta
chr15_+_73344824	0.487	NM_001172623 NM_001172624 NM_002499	NEO1	neogenin 1
chr22_-_43042976	0.487	NM_001129819 NM_001171661 NM_007326	CYB5R3	cytochrome b5 reductase 3
chr13_+_109281569	0.482	NM_001198950	MYO16	myosin XVI
chr5_+_14664764	0.478	NM_138348	FAM105B	family with sequence similarity 105, member B
chr5_+_132009372	0.477	NM_000589 NM_172348	IL4	interleukin 4
chr15_+_52311408	0.476	NM_002748	MAPK6	mitogen-activated protein kinase 6
chr17_+_56232493	0.476	NM_012374	OR4D1	olfactory receptor, family 4, subfamily D, member 1
chr1_-_85930610	0.472		DDAH1	dimethylarginine dimethylaminohydrolase 1
chr16_-_75590107	0.470	NM_001077416 NM_001077418 NM_001077419	TMEM231	transmembrane protein 231
chr15_+_52311432	0.469		MAPK6	mitogen-activated protein kinase 6
chr6_+_64282449	0.467		PTP4A1	protein tyrosine phosphatase type IVA, member 1
chr5_+_94727047	0.465	NM_152548	FAM81B	family with sequence similarity 81, member B
chr14_-_76447445	0.460		TGFB3	transforming growth factor, beta 3
chr7_+_134576187	0.459		CALD1	caldesmon 1
chr2_+_27719702	0.459	NM_001486	GCKR	glucokinase (hexokinase 4) regulator
chr4_-_177116713	0.458	NM_144644	SPATA4	spermatogenesis associated 4
chr15_-_40857229	0.455	NM_001080791 NM_001080792 NM_052849	C15orf57	chromosome 15 open reading frame 57
chr1_-_12677347	0.454	NM_004753	DHRS3	dehydrogenase/reductase (SDR family) member 3
chr14_+_67827087	0.453		EIF2S1	eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa
chr12_-_89746238	0.452		DUSP6	dual specificity phosphatase 6
chr1_-_240775448	0.451	NM_022469	GREM2	gremlin 2
chr19_-_44174497	0.450	NM_001005376 NM_001005377 NM_002659	PLAUR	plasminogen activator, urokinase receptor
chr5_+_140734767	0.449	NM_018917 NM_032053	PCDHGA4	protocadherin gamma subfamily A, 4
chr8_-_119123804	0.449	NM_000127	EXT1	exostosin 1
chr5_-_138718941	0.447		SLC23A1	solute carrier family 23 (nucleobase transporters), member 1
chr17_-_7590731	0.447	NM_000546 NM_001126112 NM_001126113 NM_001126114	TP53	tumor protein p53
chr17_-_39306053	0.446	NM_033188	KRTAP4-5	keratin associated protein 4-5
chr17_+_32612686	0.444	NM_002986	CCL11	chemokine (C-C motif) ligand 11
chr9_-_38069082	0.443		SHB	Src homology 2 domain containing adaptor protein B
chr17_+_25799024	0.442	NM_014238	KSR1	kinase suppressor of ras 1
chr11_+_61957687	0.440	NM_006552	SCGB1D1	secretoglobin, family 1D, member 1
chr13_+_97928414	0.439		MBNL2	muscleblind-like 2 (Drosophila)
chr10_-_92681025	0.437	NM_014391	ANKRD1	ankyrin repeat domain 1 (cardiac muscle)
chr9_+_109686436	0.437		ZNF462	zinc finger protein 462
chr10_+_70847857	0.436		SRGN	serglycin
chr20_+_43343523	0.433		WISP2	WNT1 inducible signaling pathway protein 2
chr2_-_128100673	0.432	NM_006609	MAP3K2	mitogen-activated protein kinase kinase kinase 2
chr11_-_30601919	0.428	NM_001584	MPPED2	metallophosphoesterase domain containing 2
chr3_-_93747453	0.428	NM_001001850	STX19	syntaxin 19
chr4_-_82126200	0.428	NM_006259	PRKG2	protein kinase, cGMP-dependent, type II
chr17_+_7533452	0.427	NM_001040 NM_001146279 NM_001146280 NM_001146281	SHBG	sex hormone-binding globulin
chr17_+_21191347	0.426	NM_002756	MAP2K3	mitogen-activated protein kinase kinase 3
chr12_-_49351297	0.424		ARF3	ADP-ribosylation factor 3
chr12_+_26348488	0.424	NM_005086	SSPN	sarcospan (Kras oncogene-associated gene)
chr2_+_154728424	0.423	NM_052917	GALNT13	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 13 (GalNAc-T13)
chr15_-_50405512	0.421		ATP8B4	ATPase, class I, type 8B, member 4
chr5_+_156820161	0.414		CYFIP2	cytoplasmic FMR1 interacting protein 2
chr1_-_173174611	0.411		TNFSF4	tumor necrosis factor (ligand) superfamily, member 4
chr17_-_39216343	0.409	NM_001165252	LOC730755	keratin associated protein 2-4-like
chrX_+_69642880	0.409	NM_001171191 NM_001171192 NM_001171193 NM_017711	GDPD2	glycerophosphodiester phosphodiesterase domain containing 2
chr17_-_76836852	0.407	NM_025090	USP36	ubiquitin specific peptidase 36
chr1_-_161102210	0.406	NM_001039712	DEDD	death effector domain containing
chr1_+_165796652	0.405	NM_012474	UCK2	uridine-cytidine kinase 2
chrX_+_38211735	0.403	NM_000531	OTC	ornithine carbamoyltransferase
chr12_-_89745997	0.403		DUSP6	dual specificity phosphatase 6
chr20_+_138121	0.402	NM_139074	DEFB127	defensin, beta 127
chr21_-_36421578	0.402		RUNX1	runt-related transcription factor 1
chr7_-_50772997	0.400	NM_001001550	GRB10	growth factor receptor-bound protein 10
chr16_-_81110803	0.397	NM_001100873 NM_152337	C16orf46	chromosome 16 open reading frame 46
chr18_+_42792946	0.396	NM_001242692	SLC14A2	solute carrier family 14 (urea transporter), member 2
chr17_-_74497406	0.391	NM_024599	RHBDF2	rhomboid 5 homolog 2 (Drosophila)
chr1_-_205912546	0.388	NM_052934 NM_134325	SLC26A9	solute carrier family 26, member 9
chr14_-_24047428	0.386		JPH4	junctophilin 4
chr12_-_26277807	0.386	NM_030762	BHLHE41	basic helix-loop-helix family, member e41

Gene overrepresentation in process category:

enrichment	p-value	GO term	description
1.93	1.35e-08	GO:0007154	cell communication
1.42	1.35e-08	GO:0023052	signaling
1.94	5.31e-06	GO:0007267	cell-cell signaling
1.37	1.34e-05	GO:0007165	signal transduction
1.32	1.93e-05	GO:0051716	cellular response to stimulus
1.26	7.20e-05	GO:0032501	multicellular organismal process
1.19	1.37e-04	GO:0065007	biological regulation
2.01	6.27e-04	GO:0019226	transmission of nerve impulse
2.01	6.27e-04	GO:0035637	multicellular organismal signaling
1.43	8.79e-04	GO:0065008	regulation of biological quality
2.22	1.05e-03	GO:0044057	regulation of system process
1.17	3.31e-03	GO:0050789	regulation of biological process
1.99	4.46e-03	GO:0007268	synaptic transmission
1.18	5.17e-03	GO:0050794	regulation of cellular process
1.28	5.64e-03	GO:0032502	developmental process
1.63	1.16e-02	GO:0006811	ion transport
1.75	1.37e-02	GO:0071310	cellular response to organic substance
2.08	1.41e-02	GO:0071495	cellular response to endogenous stimulus
1.30	1.59e-02	GO:0048856	anatomical structure development
1.19	1.64e-02	GO:0050896	response to stimulus
1.63	1.79e-02	GO:0040011	locomotion
1.38	2.00e-02	GO:0030154	cell differentiation
1.28	2.30e-02	GO:0007275	multicellular organismal development
1.43	2.58e-02	GO:0023051	regulation of signaling
2.07	3.30e-02	GO:0032870	cellular response to hormone stimulus
1.27	3.50e-02	GO:0051179	localization
1.30	4.60e-02	GO:0048731	system development
1.57	4.90e-02	GO:0070887	cellular response to chemical stimulus

Gene overrepresentation in compartment category:

enrichment	p-value	GO term	description
1.47	2.85e-06	GO:0044459	plasma membrane part
1.58	1.11e-04	GO:0005887	integral to plasma membrane
1.57	1.72e-04	GO:0031226	intrinsic to plasma membrane
1.41	4.87e-04	GO:0005576	extracellular region
2.51	1.51e-03	GO:0030424	axon
1.95	2.13e-03	GO:0043005	neuron projection
1.24	2.99e-03	GO:0071944	cell periphery
1.24	4.17e-03	GO:0005886	plasma membrane
2.47	1.31e-02	GO:0045211	postsynaptic membrane
1.85	1.36e-02	GO:0045202	synapse
1.96	2.66e-02	GO:0044456	synapse part
2.19	3.88e-02	GO:0030425	dendrite

Gene overrepresentation in function category:

enrichment	p-value	GO term	description
1.74	5.46e-05	GO:0022891	substrate-specific transmembrane transporter activity
1.19	6.38e-05	GO:0005515	protein binding
2.07	1.98e-04	GO:0015267	channel activity
1.65	1.98e-04	GO:0005102	receptor binding
2.06	2.14e-04	GO:0022803	passive transmembrane transporter activity
1.67	2.76e-04	GO:0022857	transmembrane transporter activity
2.05	4.09e-04	GO:0022838	substrate-specific channel activity
1.73	6.79e-04	GO:0015075	ion transmembrane transporter activity
1.61	8.19e-04	GO:0022892	substrate-specific transporter activity
1.96	2.99e-03	GO:0005216	ion channel activity
1.77	5.86e-03	GO:0008324	cation transmembrane transporter activity
1.49	8.07e-03	GO:0005215	transporter activity
2.03	1.02e-02	GO:0022836	gated channel activity