Motif ID: ESRRA.p2

Z-value: 0.903


Transcription factors associated with ESRRA.p2:

Gene SymbolEntrez IDGene Name
ESRRA 2101 estrogen-related receptor alpha

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.p-valuePlot
ESRRAchr11_+_640730400.125.7e-01Click!


Activity profile for motif ESRRA.p2.

activity profile for motif ESRRA.p2


Sorted Z-values histogram for motif ESRRA.p2

Sorted Z-values for motif ESRRA.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of ESRRA.p2

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.


View svg image
View png image


Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr16_+_57050985 1.256 NM_032206
NLRC5
NLR family, CARD domain containing 5
chr20_+_39969420 1.224 NM_022896
LPIN3
lipin 3
chr12_+_78225068 1.037 NM_014903
NAV3
neuron navigator 3
chr6_+_43149925 0.996 CUL9
cullin 9
chr21_+_27011766 0.890 JAM2
junctional adhesion molecule 2
chr19_+_35629727 0.841 NM_021902
FXYD1
FXYD domain containing ion transport regulator 1
chr11_-_64528186 0.803 NM_001164716
NM_005609
PYGM

phosphorylase, glycogen, muscle

chr12_-_120554557 0.793 RAB35
RAB35, member RAS oncogene family
chr10_+_81107242 0.789 PPIF
peptidylprolyl isomerase F
chr1_-_144994839 0.710 PDE4DIP
phosphodiesterase 4D interacting protein
chr17_-_4167028 0.652 NM_016376
NM_020740
ANKFY1

ankyrin repeat and FYVE domain containing 1

chr1_-_8003224 0.652 NM_001561
TNFRSF9
tumor necrosis factor receptor superfamily, member 9
chr1_+_205236591 0.600 TMCC2
transmembrane and coiled-coil domain family 2
chr10_+_81107259 0.596 PPIF
peptidylprolyl isomerase F
chr22_+_32149936 0.595 NM_001242897
DEPDC5
DEP domain containing 5
chr4_-_76957139 0.593 NM_005409
CXCL11
chemokine (C-X-C motif) ligand 11
chr19_-_1513187 0.589 NM_213604
ADAMTSL5
ADAMTS-like 5
chr1_-_31712733 0.586 NM_024522
NKAIN1
Na+/K+ transporting ATPase interacting 1
chr1_+_209848659 0.581 NM_015714
G0S2
G0/G1switch 2
chr19_-_1512997 0.579 ADAMTSL5
ADAMTS-like 5
chr22_+_32150002 0.577 NM_001007188
NM_001242896
NM_014662
DEPDC5


DEP domain containing 5


chr20_+_58179601 0.567 NM_080672
PHACTR3
phosphatase and actin regulator 3
chr1_-_200992824 0.563 NM_001252100
NM_001252102
NM_001252103
NM_017596
KIF21B



kinesin family member 21B



chr19_+_19322763 0.557 NM_004386
NCAN
neurocan
chr11_-_132812870 0.556 NM_002545
OPCML
opioid binding protein/cell adhesion molecule-like
chr22_+_32149962 0.555 DEPDC5
DEP domain containing 5
chr4_-_25032306 0.552 NM_018176
LGI2
leucine-rich repeat LGI family, member 2
chr21_+_27012067 0.551 JAM2
junctional adhesion molecule 2
chr20_-_62130390 0.550 NM_001958
EEF1A2
eukaryotic translation elongation factor 1 alpha 2
chr22_+_30821610 0.542 NM_001003704
NM_016498
MTFP1

mitochondrial fission process 1

chr4_-_76944585 0.540 NM_001565
CXCL10
chemokine (C-X-C motif) ligand 10
chr17_-_49198084 0.523 NM_001130527
NM_001130528
NM_003971
SPAG9


sperm associated antigen 9


chr11_+_10472223 0.512 NM_000480
AMPD3
adenosine monophosphate deaminase 3
chr10_-_99790346 0.509 CRTAC1
cartilage acidic protein 1
chr4_+_24797203 0.497 SOD3
superoxide dismutase 3, extracellular
chr1_+_152881022 0.493 NM_005547
IVL
involucrin
chr8_+_145149985 0.492 CYC1
cytochrome c-1
chr5_+_218355 0.486 NM_004168
SDHA
succinate dehydrogenase complex, subunit A, flavoprotein (Fp)
chr5_+_218447 0.484 SDHA
succinate dehydrogenase complex, subunit A, flavoprotein (Fp)
chr1_-_144994908 0.479 PDE4DIP
phosphodiesterase 4D interacting protein
chr4_+_24797084 0.479 NM_003102
SOD3
superoxide dismutase 3, extracellular
chr12_-_120554612 0.472 NM_001167606
NM_006861
RAB35

RAB35, member RAS oncogene family

chr22_-_47134130 0.472 NM_022766
CERK
ceramide kinase
chr17_-_48264039 0.467 COL1A1
collagen, type I, alpha 1
chr12_+_6976583 0.460 NM_001159287
NM_000365
TPI1

triosephosphate isomerase 1

chr12_+_51818592 0.457 NM_001039960
NM_004858
SLC4A8

solute carrier family 4, sodium bicarbonate cotransporter, member 8

chr5_+_218441 0.452 SDHA
succinate dehydrogenase complex, subunit A, flavoprotein (Fp)
chr16_-_66952729 0.451 NM_001204744
NM_001204745
NM_001204746
NM_004062
CDH16



cadherin 16, KSP-cadherin



chr14_+_105452615 0.449 NM_174891
C14orf79
chromosome 14 open reading frame 79
chr10_+_99185977 0.447 PGAM1
phosphoglycerate mutase 1 (brain)
chr11_+_65190272 0.445


chr8_+_99129488 0.440 NM_001145860
NM_001145861
POP1

processing of precursor 1, ribonuclease P/MRP subunit (S. cerevisiae)

chr13_-_33859835 0.434 NM_178006
STARD13
StAR-related lipid transfer (START) domain containing 13
chr7_+_45614179 0.425 ADCY1
adenylate cyclase 1 (brain)
chr17_+_4981754 0.422 ZFP3
zinc finger protein 3 homolog (mouse)
chr21_+_27012045 0.419 JAM2
junctional adhesion molecule 2
chr14_-_58893867 0.417 TIMM9
translocase of inner mitochondrial membrane 9 homolog (yeast)
chr3_-_14166292 0.410 CHCHD4
coiled-coil-helix-coiled-coil-helix domain containing 4
chr10_+_81107228 0.409 PPIF
peptidylprolyl isomerase F
chr20_+_32077780 0.407 CBFA2T2
core-binding factor, runt domain, alpha subunit 2; translocated to, 2
chr6_+_31554475 0.407 NM_205837
LST1
leukocyte specific transcript 1
chr6_+_34206567 0.406 NM_145905
HMGA1
high mobility group AT-hook 1
chr3_-_14166370 0.405 NM_001098502
NM_144636
CHCHD4

coiled-coil-helix-coiled-coil-helix domain containing 4

chr3_-_113465101 0.402 NM_025146
NAA50
N(alpha)-acetyltransferase 50, NatE catalytic subunit
chr19_-_4535202 0.398 NM_001013706
PLIN5
perilipin 5
chr5_-_148034089 0.395 HTR4
5-hydroxytryptamine (serotonin) receptor 4
chr2_-_118771571 0.387 CCDC93
coiled-coil domain containing 93
chr10_+_81107219 0.385 NM_005729
PPIF
peptidylprolyl isomerase F
chr3_-_14166246 0.384 CHCHD4
coiled-coil-helix-coiled-coil-helix domain containing 4
chr3_-_14166228 0.382 CHCHD4
coiled-coil-helix-coiled-coil-helix domain containing 4
chr1_-_173886401 0.379 SERPINC1
serpin peptidase inhibitor, clade C (antithrombin), member 1
chr4_-_157892054 0.378 PDGFC
platelet derived growth factor C
chr16_+_2587951 0.377 NM_002613
NM_031268
PDPK1

3-phosphoinositide dependent protein kinase-1

chr10_+_99186004 0.368 PGAM1
phosphoglycerate mutase 1 (brain)
chr2_-_31440378 0.366 NM_001145122
CAPN14
calpain 14
chr3_-_50605062 0.366 NM_001171740
NM_001171743
NM_016210
C3orf18


chromosome 3 open reading frame 18


chr3_+_113666544 0.365 NM_173570
ZDHHC23
zinc finger, DHHC-type containing 23
chrX_+_37026431 0.361 NM_001013736
FAM47C
family with sequence similarity 47, member C
chr10_+_60028885 0.360 NM_018464
CISD1
CDGSH iron sulfur domain 1
chr15_-_41694619 0.360 NM_016013
NDUFAF1
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, assembly factor 1
chr16_+_30937206 0.357 FBXL19
F-box and leucine-rich repeat protein 19
chr12_-_120554558 0.357 RAB35
RAB35, member RAS oncogene family
chr17_+_79679399 0.356 SLC25A10
solute carrier family 25 (mitochondrial carrier; dicarboxylate transporter), member 10
chr10_+_99186017 0.356 NM_002629
PGAM1
phosphoglycerate mutase 1 (brain)
chr19_-_4517715 0.354 NM_001080400
PLIN4
perilipin 4
chr17_-_2614926 0.348 NM_015229
KIAA0664
KIAA0664
chr4_+_7045222 0.345 TADA2B
transcriptional adaptor 2B
chr10_-_118765087 0.344 NM_001127211
NM_018330
KIAA1598

KIAA1598

chr15_-_42783293 0.344 ZFP106
zinc finger protein 106 homolog (mouse)
chr3_-_50608421 0.342 NM_001171741
C3orf18
chromosome 3 open reading frame 18
chr20_-_13765509 0.334 NM_016649
ESF1
ESF1, nucleolar pre-rRNA processing protein, homolog (S. cerevisiae)
chr5_+_218428 0.331 SDHA
succinate dehydrogenase complex, subunit A, flavoprotein (Fp)
chr15_-_89010607 0.330 NM_022163
MRPL46
mitochondrial ribosomal protein L46
chr11_-_86666211 0.329 NM_012193
FZD4
frizzled family receptor 4
chr12_+_6976694 0.327 TPI1
triosephosphate isomerase 1
chr14_-_70546863 0.326 NM_182936
NM_001130417
SLC8A3

solute carrier family 8 (sodium/calcium exchanger), member 3

chr11_+_35198199 0.325 CD44
CD44 molecule (Indian blood group)
chr1_-_241520467 0.324 NM_002924
RGS7
regulator of G-protein signaling 7
chr10_+_99186040 0.322 PGAM1
phosphoglycerate mutase 1 (brain)
chr3_-_49158171 0.319 USP19
ubiquitin specific peptidase 19
chr3_-_49158256 0.319 USP19
ubiquitin specific peptidase 19
chr16_+_2587989 0.317 PDPK1
3-phosphoinositide dependent protein kinase-1
chr10_+_99186042 0.317 PGAM1
phosphoglycerate mutase 1 (brain)
chr3_-_42744318 0.316 NM_020707
HHATL
hedgehog acyltransferase-like
chr6_+_31554975 0.316 NM_001166538
NM_007161
NM_205840
LST1


leukocyte specific transcript 1


chr10_-_35363167 0.313 NM_001198778
NM_001198779
CUL2

cullin 2

chr7_+_39663257 0.313 RALA
v-ral simian leukemia viral oncogene homolog A (ras related)
chr11_-_65686439 0.312 NM_001135635
NM_031450
C11orf68

chromosome 11 open reading frame 68

chr1_-_72748147 0.310 NM_173808
NEGR1
neuronal growth regulator 1
chr18_-_5543967 0.309 NM_012307
EPB41L3
erythrocyte membrane protein band 4.1-like 3
chr7_-_1015144 0.308 NM_001031617
ADAP1
COX19
ArfGAP with dual PH domains 1
COX19 cytochrome c oxidase assembly homolog (S. cerevisiae)
chr1_+_46379258 0.308 MAST2
microtubule associated serine/threonine kinase 2
chr17_+_79679370 0.308 NM_012140
SLC25A10
solute carrier family 25 (mitochondrial carrier; dicarboxylate transporter), member 10
chr10_+_99186012 0.307 PGAM1
phosphoglycerate mutase 1 (brain)
chr19_-_55574434 0.307 NM_001145971
RDH13
retinol dehydrogenase 13 (all-trans/9-cis)
chr19_+_40194945 0.307 NM_020129
NM_203471
LGALS14

lectin, galactoside-binding, soluble, 14

chr3_-_167813058 0.297 GOLIM4
golgi integral membrane protein 4
chr5_-_45696219 0.296 NM_021072
HCN1
hyperpolarization activated cyclic nucleotide-gated potassium channel 1
chr3_-_49158357 0.296 NM_001199160
NM_001199161
NM_001199162
NM_006677
USP19



ubiquitin specific peptidase 19



chr11_-_65793849 0.295 NM_053054
CATSPER1
cation channel, sperm associated 1
chr9_-_100954883 0.295 NM_052820
CORO2A
coronin, actin binding protein, 2A
chr12_-_77272767 0.294 NM_001321
CSRP2
cysteine and glycine-rich protein 2
chr9_-_136344182 0.289 NM_001145099
NM_017585
SLC2A6

solute carrier family 2 (facilitated glucose transporter), member 6

chr3_-_49158239 0.289 USP19
ubiquitin specific peptidase 19
chr3_-_121379701 0.288 HCLS1
hematopoietic cell-specific Lyn substrate 1
chr1_+_20396652 0.286 NM_000929
PLA2G5
phospholipase A2, group V
chr22_-_32341298 0.283 NM_015372
C22orf24
chromosome 22 open reading frame 24
chr7_-_140624280 0.283 NM_004333
BRAF
v-raf murine sarcoma viral oncogene homolog B1
chr7_+_45614081 0.283 NM_021116
ADCY1
adenylate cyclase 1 (brain)
chr3_-_49158244 0.283 USP19
ubiquitin specific peptidase 19
chr18_-_74207145 0.282 NM_014643
ZNF516
zinc finger protein 516
chr11_-_84634219 0.282 DLG2
discs, large homolog 2 (Drosophila)
chr3_-_42845911 0.280 NM_001099668
HIGD1A
HIG1 hypoxia inducible domain family, member 1A
chr16_+_2588021 0.280 PDPK1
3-phosphoinositide dependent protein kinase-1
chr16_+_31366519 0.280 ITGAX
integrin, alpha X (complement component 3 receptor 4 subunit)
chr3_-_33260706 0.278 NM_015551
SUSD5
sushi domain containing 5
chr16_+_2588000 0.278 PDPK1
3-phosphoinositide dependent protein kinase-1
chr3_-_42845946 0.275 NM_001099669
NM_014056
HIGD1A

HIG1 hypoxia inducible domain family, member 1A

chrX_-_153744372 0.274 NM_001171132
NM_001171133
NM_001171134
NM_021806
FAM3A



family with sequence similarity 3, member A



chr19_-_58067724 0.273 NM_001039654
ZNF550
zinc finger protein 550
chr20_-_44333655 0.273 NM_172006
NM_172131
WFDC10B

WAP four-disulfide core domain 10B

chr22_-_44258210 0.273 NM_014351
SULT4A1
sulfotransferase family 4A, member 1
chr11_-_34379526 0.272 NM_145804
ABTB2
ankyrin repeat and BTB (POZ) domain containing 2
chr1_-_27481400 0.271 NM_003047
SLC9A1
solute carrier family 9 (sodium/hydrogen exchanger), member 1
chr11_-_57194591 0.270 NM_199329
SLC43A3
solute carrier family 43, member 3
chr22_+_24199058 0.270 NM_001024938
NM_030807
SLC2A11

solute carrier family 2 (facilitated glucose transporter), member 11

chr16_+_2588051 0.269 PDPK1
3-phosphoinositide dependent protein kinase-1
chr3_-_123339423 0.269 NM_053031
NM_053032
MYLK

myosin light chain kinase

chr13_-_44361032 0.269 NM_001242863
NM_017993
ENOX1

ecto-NOX disulfide-thiol exchanger 1

chr4_+_74301932 0.268 NM_001134
AFP
alpha-fetoprotein
chr5_+_34684611 0.268 NM_001145521
NM_001145525
RAI14

retinoic acid induced 14

chr12_-_133306531 0.267 ANKLE2
ankyrin repeat and LEM domain containing 2
chr1_+_171283372 0.264 NM_002022
FMO4
flavin containing monooxygenase 4
chr15_-_83621350 0.262 NM_004839
NM_199330
HOMER2

homer homolog 2 (Drosophila)

chr1_+_113236679 0.261 MOV10
Mov10, Moloney leukemia virus 10, homolog (mouse)
chr17_+_4981721 0.260 NM_153018
ZFP3
zinc finger protein 3 homolog (mouse)
chr5_-_137911317 0.260 NM_004134
HSPA9
heat shock 70kDa protein 9 (mortalin)
chr3_-_48130283 0.259 MAP4
microtubule-associated protein 4
chr1_-_156786500 0.259 NM_001161441
NM_001161442
NM_001161444
NM_003975
SH2D2A



SH2 domain containing 2A



chr17_-_34308455 0.258 NM_004590
CCL16
chemokine (C-C motif) ligand 16
chr20_-_31989303 0.258 CDK5RAP1
CDK5 regulatory subunit associated protein 1
chr6_-_33281790 0.258 TAPBP
TAP binding protein (tapasin)
chr15_+_78441737 0.257 IDH3A
isocitrate dehydrogenase 3 (NAD+) alpha
chr3_+_10290357 0.254 TATDN2
TatD DNase domain containing 2
chr20_+_32077904 0.254 NM_001032999
CBFA2T2
core-binding factor, runt domain, alpha subunit 2; translocated to, 2
chr1_-_241683011 0.254 FH
fumarate hydratase
chr3_+_10068139 0.253 FANCD2
Fanconi anemia, complementation group D2
chrX_+_103411235 0.253 FAM199X
family with sequence similarity 199, X-linked
chr8_+_145149978 0.251 CYC1
cytochrome c-1
chr16_+_56966025 0.250 HERPUD1
homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
chr20_+_44462788 0.250 SNX21
sorting nexin family member 21
chr2_+_182850550 0.247 NM_001080545
PPP1R1C
protein phosphatase 1, regulatory (inhibitor) subunit 1C
chr20_-_31989330 0.246 NM_016082
NM_016408
CDK5RAP1

CDK5 regulatory subunit associated protein 1

chr3_-_131221649 0.245 NM_007208
MRPL3
mitochondrial ribosomal protein L3
chr8_+_99439249 0.245 NM_020697
KCNS2
potassium voltage-gated channel, delayed-rectifier, subfamily S, member 2
chr11_-_57194556 0.244 SLC43A3
solute carrier family 43, member 3
chrX_-_132549421 0.242 GPC4
glypican 4
chr8_+_145149936 0.241 NM_001916
CYC1
cytochrome c-1
chr19_-_40931880 0.236 NM_013376
SERTAD1
SERTA domain containing 1
chr17_-_79792923 0.236 NM_001007533
PPP1R27
protein phosphatase 1, regulatory subunit 27
chr4_-_7069755 0.234 NM_025196
GRPEL1
GrpE-like 1, mitochondrial (E. coli)
chr2_-_44223131 0.233 NM_133259
LRPPRC
leucine-rich PPR-motif containing
chr8_-_131028833 0.233 FAM49B
family with sequence similarity 49, member B
chr22_+_32150847 0.230 NM_001136029
DEPDC5
DEP domain containing 5
chr1_+_152635871 0.230 NM_178430
LCE2D
late cornified envelope 2D
chr15_+_40453263 0.229 BUB1B
budding uninhibited by benzimidazoles 1 homolog beta (yeast)
chr15_+_75494235 0.225 C15orf39
chromosome 15 open reading frame 39
chr8_-_131028674 0.223 FAM49B
family with sequence similarity 49, member B
chr1_+_159557615 0.223 NM_001639
APCS
amyloid P component, serum
chr11_-_57194512 0.223 NM_014096
SLC43A3
solute carrier family 43, member 3
chr9_-_117150217 0.222 AKNA
AT-hook transcription factor
chr1_-_23504273 0.221 LUZP1
leucine zipper protein 1
chr15_+_75494233 0.221 C15orf39
chromosome 15 open reading frame 39
chr17_-_33416238 0.221 RFFL
ring finger and FYVE-like domain containing 1
chr9_+_130965668 0.220 DNM1
dynamin 1
chr19_+_58694444 0.218 ZNF274
zinc finger protein 274
chr15_-_90349819 0.217 ANPEP
alanyl (membrane) aminopeptidase
chr11_-_3862183 0.216 NM_001665
RHOG
ras homolog gene family, member G (rho G)
chr12_-_120554453 0.216 RAB35
RAB35, member RAS oncogene family
chr19_-_43031343 0.213 CEACAM1
carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.44 1.56e-05 GO:0006810 transport
1.42 3.41e-05 GO:0051234 establishment of localization
1.37 1.43e-04 GO:0051179 localization
3.48 1.61e-04 GO:0045333 cellular respiration
2.28 2.42e-04 GO:0006091 generation of precursor metabolites and energy
2.49 9.36e-04 GO:0015980 energy derivation by oxidation of organic compounds
3.90 2.31e-03 GO:0006839 mitochondrial transport
3.46 7.21e-03 GO:0022904 respiratory electron transport chain
5.35 1.90e-02 GO:0009060 aerobic respiration
5.35 1.90e-02 GO:0070585 protein localization in mitochondrion
7.27 4.47e-02 GO:0072384 organelle transport along microtubule

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
2.28 8.07e-10 GO:0044429 mitochondrial part
2.49 1.12e-08 GO:0005740 mitochondrial envelope
1.81 1.38e-08 GO:0005739 mitochondrion
2.52 1.47e-08 GO:0031966 mitochondrial membrane
2.79 6.56e-08 GO:0005743 mitochondrial inner membrane
2.66 1.33e-07 GO:0019866 organelle inner membrane
3.98 2.03e-07 GO:0044455 mitochondrial membrane part
2.00 1.80e-06 GO:0031975 envelope
2.01 1.84e-06 GO:0031967 organelle envelope
1.18 8.98e-05 GO:0005737 cytoplasm
1.23 2.39e-04 GO:0044444 cytoplasmic part
9.64 4.39e-03 GO:0005744 mitochondrial inner membrane presequence translocase complex
1.40 4.89e-03 GO:0005829 cytosol
2.19 1.36e-02 GO:0005759 mitochondrial matrix
3.48 2.69e-02 GO:0070469 respiratory chain
4.68 3.16e-02 GO:0042645 mitochondrial nucleoid
4.54 4.04e-02 GO:0009295 nucleoid

Gene overrepresentation in function category:

enrichment   p-value GO term description
14.13 2.70e-02 GO:0008048 calcium sensitive guanylate cyclase activator activity
2.33 4.27e-02 GO:0005529 sugar binding