Motif ID: EWSR1-FLI1.p2

Z-value: 0.626


Transcription factors associated with EWSR1-FLI1.p2:

fusion protein between EWSR1 and FLI1 in an oncogenic event

Gene SymbolEntrez IDGene Name
EWSR1 2130 Ewing sarcoma breakpoint region 1
FLI1 2313 Friend leukemia virus integration 1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.p-valuePlot
FLI1chr11_+_128563772-0.164.5e-01Click!
EWSR1chr22_+_296639970.029.3e-01Click!


Activity profile for motif EWSR1-FLI1.p2.

activity profile for motif EWSR1-FLI1.p2


Sorted Z-values histogram for motif EWSR1-FLI1.p2

Sorted Z-values for motif EWSR1-FLI1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of EWSR1-FLI1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr20_+_43374487 2.222 NM_022358
KCNK15
potassium channel, subfamily K, member 15
chr3_-_164914448 0.878 NM_014926
SLITRK3
SLIT and NTRK-like family, member 3
chrX_+_1401570 0.665 NM_001161530
NM_172247
CSF2RA

colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage)

chr13_-_33780142 0.663 NM_001243474
NM_052851
STARD13

StAR-related lipid transfer (START) domain containing 13

chrY_+_1351570 0.659 NM_001161530
NM_172247
CSF2RA

colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage)

chr1_+_167599329 0.657 NM_052862
RCSD1
RCSD domain containing 1
chr6_+_36916038 0.591 NM_001199159
PI16
peptidase inhibitor 16
chr6_-_134496833 0.557 SGK1
serum/glucocorticoid regulated kinase 1
chr6_-_134497069 0.557 NM_001143678
SGK1
serum/glucocorticoid regulated kinase 1
chr2_+_167744996 0.550 NM_001079810
NM_001199143
NM_152381
XIRP2


xin actin-binding repeat containing 2


chr18_+_43405544 0.541 NM_213602
SIGLEC15
sialic acid binding Ig-like lectin 15
chr2_+_113816214 0.486 NM_173170
IL36RN
interleukin 36 receptor antagonist
chr5_-_137089434 0.482 HNRNPA0
heterogeneous nuclear ribonucleoprotein A0
chr19_-_17958773 0.423 JAK3
Janus kinase 3
chr5_+_35856990 0.357 NM_002185
IL7R
interleukin 7 receptor
chr19_-_6591012 0.341 CD70
CD70 molecule
chr1_-_31230594 0.339 LAPTM5
lysosomal protein transmembrane 5
chr2_-_99917638 0.324 NM_174898
LYG1
lysozyme G-like 1
chr1_-_31230673 0.318 NM_006762
LAPTM5
lysosomal protein transmembrane 5
chr12_-_117175634 0.316 NM_024738
C12orf49
chromosome 12 open reading frame 49
chr11_+_63974190 0.310 FERMT3
fermitin family member 3
chr2_+_113816684 0.309 NM_012275
IL36RN
interleukin 36 receptor antagonist
chr6_+_26383323 0.296 NM_001197238
NM_001197239
NM_001197240
NM_006995
NM_181531
NM_001197237
BTN2A2





butyrophilin, subfamily 2, member A2





chr3_-_42307661 0.294 NM_000729
CCK
cholecystokinin
chr12_+_46123476 0.293 ARID2
AT rich interactive domain 2 (ARID, RFX-like)
chr8_-_38008332 0.279 NM_000349
STAR
steroidogenic acute regulatory protein
chr16_+_69140121 0.278 NM_138612
HAS3
hyaluronan synthase 3
chr5_-_137090033 0.275 HNRNPA0
heterogeneous nuclear ribonucleoprotein A0
chr12_+_90103470 0.266 LOC338758
uncharacterized LOC338758
chr8_+_133879202 0.260 NM_003235
TG
thyroglobulin
chr21_+_40177754 0.254 ETS2
v-ets erythroblastosis virus E26 oncogene homolog 2 (avian)
chr5_-_142000899 0.252 NM_001144892
FGF1
fibroblast growth factor 1 (acidic)
chr5_-_137089990 0.249 HNRNPA0
heterogeneous nuclear ribonucleoprotein A0
chr5_-_137089754 0.237 HNRNPA0
heterogeneous nuclear ribonucleoprotein A0
chr12_-_117175844 0.236 C12orf49
chromosome 12 open reading frame 49
chr3_-_50378238 0.231 NM_001206957
NM_007182
NM_170714
RASSF1


Ras association (RalGDS/AF-6) domain family member 1


chr2_+_65215577 0.230 NM_001193493
SLC1A4
solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
chr5_-_59189620 0.228 NM_001104631
PDE4D
phosphodiesterase 4D, cAMP-specific
chr12_+_56075329 0.215 NM_152637
METTL7B
methyltransferase like 7B
chr11_-_77122877 0.215 PAK1
p21 protein (Cdc42/Rac)-activated kinase 1
chr10_+_88718287 0.211 NM_003087
SNCG
synuclein, gamma (breast cancer-specific protein 1)
chr1_+_248020607 0.209 TRIM58
tripartite motif containing 58
chr6_+_31638727 0.208 NM_021221
LY6G5B
lymphocyte antigen 6 complex, locus G5B
chr3_-_107809754 0.203 NM_001777
NM_198793
CD47

CD47 molecule

chr2_+_37571752 0.203 NM_012413
QPCT
glutaminyl-peptide cyclotransferase
chr2_+_79740059 0.202 NM_001164883
NM_004389
CTNNA2

catenin (cadherin-associated protein), alpha 2

chr4_+_110736636 0.198 NM_018983
NM_032993
GAR1

GAR1 ribonucleoprotein homolog (yeast)

chr18_+_9136742 0.198 NM_001083625
NM_015208
ANKRD12

ankyrin repeat domain 12

chr21_+_40177847 0.198 NM_005239
ETS2
v-ets erythroblastosis virus E26 oncogene homolog 2 (avian)
chr10_-_14372807 0.196 NM_018027
FRMD4A
FERM domain containing 4A
chr14_-_76448091 0.193 NM_003239
TGFB3
transforming growth factor, beta 3
chr5_+_150040402 0.193 NM_001122853
NM_133371
MYOZ3

myozenin 3

chr2_+_79740171 0.192 CTNNA2
catenin (cadherin-associated protein), alpha 2
chr12_-_9760481 0.188 NM_002258
KLRB1
killer cell lectin-like receptor subfamily B, member 1
chr19_-_6591082 0.187 CD70
CD70 molecule
chr1_+_248020481 0.183 NM_015431
TRIM58
tripartite motif containing 58
chr2_+_182756468 0.183 NM_001130445
NM_006751
SSFA2

sperm specific antigen 2

chr19_-_6591136 0.182 NM_001252
CD70
CD70 molecule
chr9_+_35538890 0.181 RUSC2
RUN and SH3 domain containing 2
chr11_+_60970983 0.170 NM_001079807
PGA3
PGA4
pepsinogen 3, group I (pepsinogen A)
pepsinogen 4, group I (pepsinogen A)
chr11_-_74442429 0.167 CHRDL2
chordin-like 2
chr18_-_45935627 0.167 ZBTB7C
zinc finger and BTB domain containing 7C
chr4_+_150999412 0.166 NM_001040260
NM_001040261
DCLK2

doublecortin-like kinase 2

chr5_+_156887026 0.160 NM_001099287
NM_001172292
NIPAL4

NIPA-like domain containing 4

chr17_-_73389708 0.158 GRB2
growth factor receptor-bound protein 2
chr12_-_1703330 0.157 NM_152441
FBXL14
F-box and leucine-rich repeat protein 14
chr11_+_71927818 0.157 NM_000803
NM_001113534
NM_001113535
NM_001113536
FOLR2



folate receptor 2 (fetal)



chr21_+_45719921 0.153 NM_002626
PFKL
phosphofructokinase, liver
chr6_+_31590468 0.148


chr15_+_90544608 0.141 NM_198526
ZNF710
zinc finger protein 710
chr2_+_106361404 0.141 NM_001004722
NM_003581
NCK2

NCK adaptor protein 2

chr21_+_45719964 0.141 PFKL
phosphofructokinase, liver
chr20_+_6748744 0.139 NM_001200
BMP2
bone morphogenetic protein 2
chr1_-_173176314 0.138 NM_003326
TNFSF4
tumor necrosis factor (ligand) superfamily, member 4
chr17_-_63052884 0.137 NM_006572
GNA13
guanine nucleotide binding protein (G protein), alpha 13
chr19_-_39368889 0.136 NM_001195833
NM_198445
RINL

Ras and Rab interactor-like

chr8_-_145701139 0.135 FOXH1
forkhead box H1
chr1_-_152009467 0.134 S100A11
S100 calcium binding protein A11
chr1_-_152009440 0.133 S100A11
S100 calcium binding protein A11
chr19_-_17958814 0.132 NM_000215
JAK3
Janus kinase 3
chr18_-_5630629 0.132 EPB41L3
erythrocyte membrane protein band 4.1-like 3
chr8_-_145701717 0.131 NM_003923
FOXH1
forkhead box H1
chr5_-_101631965 0.130 NM_180991
SLCO4C1
solute carrier organic anion transporter family, member 4C1
chr11_+_63974144 0.130 NM_031471
NM_178443
FERMT3

fermitin family member 3

chr1_-_152009406 0.128 S100A11
S100 calcium binding protein A11
chr7_-_75419063 0.127 NM_006072
CCL26
chemokine (C-C motif) ligand 26
chrX_+_56589961 0.125 NM_013444
UBQLN2
ubiquilin 2
chr2_-_105467912 0.125 LOC100506421
uncharacterized LOC100506421
chr14_-_21566728 0.124 NM_016423
ZNF219
zinc finger protein 219
chr9_+_35538628 0.122 NM_001135999
RUSC2
RUN and SH3 domain containing 2
chr1_-_6546013 0.122 NM_001042665
PLEKHG5
pleckstrin homology domain containing, family G (with RhoGef domain) member 5
chr1_-_157670280 0.121 NM_052939
FCRL3
Fc receptor-like 3
chr5_-_148442606 0.120 NM_024577
SH3TC2
SH3 domain and tetratricopeptide repeats 2
chr9_-_126692184 0.119 NM_020946
NM_024820
DENND1A

DENN/MADD domain containing 1A

chr11_-_74442185 0.119 NM_015424
CHRDL2
chordin-like 2
chr17_-_56591900 0.117 MTMR4
myotubularin related protein 4
chr4_+_119809978 0.117 NM_001128933
NM_001128934
NM_133477
SYNPO2


synaptopodin 2


chr15_+_41523465 0.116 CHP
calcium binding protein P22
chrX_+_152599544 0.115 NM_001080485
ZNF275
zinc finger protein 275
chr12_-_81331449 0.115 LIN7A
lin-7 homolog A (C. elegans)
chr17_-_10741398 0.114 NM_001101387
PIRT
phosphoinositide-interacting regulator of transient receptor potential channels
chr7_+_143412938 0.112 NM_001130026
FAM115C
family with sequence similarity 115, member C
chr11_+_1074869 0.108 NM_002457
MUC2
mucin 2, oligomeric mucus/gel-forming
chr8_-_29206321 0.106 NM_057158
DUSP4
dual specificity phosphatase 4
chr9_+_34179036 0.106 UBAP1
ubiquitin associated protein 1
chr16_+_67022487 0.105 NM_173815
CES4A
carboxylesterase 4A
chr12_+_109273856 0.105 NM_001917
DAO
D-amino-acid oxidase
chr9_+_34179023 0.104 UBAP1
ubiquitin associated protein 1
chr2_+_242127923 0.104 NM_001001666
NM_001001891
ANO7

anoctamin 7

chr11_-_8832881 0.103 NM_139157
ST5
suppression of tumorigenicity 5
chr10_+_106014467 0.097 NM_001191002
NM_004832
GSTO1

glutathione S-transferase omega 1

chr17_-_56595192 0.097 NM_004687
MTMR4
myotubularin related protein 4
chr17_+_38137081 0.096 PSMD3
proteasome (prosome, macropain) 26S subunit, non-ATPase, 3
chr12_+_10331556 0.095 NM_153022
C12orf59
chromosome 12 open reading frame 59
chr17_-_40833840 0.094 NM_016602
CCR10
chemokine (C-C motif) receptor 10
chr20_+_42187705 0.094 SGK2
serum/glucocorticoid regulated kinase 2
chr4_+_166299942 0.093 NM_001873
CPE
carboxypeptidase E
chr19_-_56092184 0.093 NM_152600
ZNF579
zinc finger protein 579
chr16_-_75569067 0.092 NM_024533
CHST5
carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 5
chr11_+_10477480 0.092 NM_001025390
AMPD3
adenosine monophosphate deaminase 3
chr12_-_49365545 0.091 NM_003394
WNT10B
wingless-type MMTV integration site family, member 10B
chr7_+_8474016 0.090 NXPH1
neurexophilin 1
chr14_-_94595925 0.090 NM_032036
IFI27L2
interferon, alpha-inducible protein 27-like 2
chr13_+_47127295 0.088 NM_001164211
NM_001164213
NM_015116
LRCH1


leucine-rich repeats and calponin homology (CH) domain containing 1


chr17_+_29058653 0.088 SUZ12P
suppressor of zeste 12 homolog pseudogene
chr17_-_63052816 0.087


chrX_+_154997396 0.086 NM_005840
SPRY3
sprouty homolog 3 (Drosophila)
chr17_+_38137106 0.084 PSMD3
proteasome (prosome, macropain) 26S subunit, non-ATPase, 3
chr1_-_11042093 0.084 NM_001170754
C1orf127
chromosome 1 open reading frame 127
chr1_+_186798031 0.083 NM_024420
PLA2G4A
phospholipase A2, group IVA (cytosolic, calcium-dependent)
chr16_-_70719693 0.081 MTSS1L
metastasis suppressor 1-like
chr4_+_77172852 0.080 NM_001136570
NM_001242939
FAM47E
FAM47E-STBD1
family with sequence similarity 47, member E
FAM47E-STBD1 readthrough
chr5_-_137090049 0.079


chrX_+_198060 0.079 NM_018390
PLCXD1
phosphatidylinositol-specific phospholipase C, X domain containing 1
chr9_+_135854097 0.078 NM_001135031
NM_004188
GFI1B

growth factor independent 1B transcription repressor

chr9_-_125675571 0.077 NM_006626
ZBTB6
zinc finger and BTB domain containing 6
chr14_+_32546445 0.077 NM_001030055
NM_001173
ARHGAP5

Rho GTPase activating protein 5

chr12_+_107168336 0.077 NM_018157
RIC8B
resistance to inhibitors of cholinesterase 8 homolog B (C. elegans)
chr6_+_116937641 0.076 NM_001010892
NM_001161664
RSPH4A

radial spoke head 4 homolog A (Chlamydomonas)

chr16_+_2083264 0.076 NM_001252073
NM_001252075
NM_001252076
SLC9A3R2


solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 2


chrX_-_132091223 0.076 HS6ST2
heparan sulfate 6-O-sulfotransferase 2
chr16_+_57220238 0.076 NM_133368
RSPRY1
ring finger and SPRY domain containing 1
chr15_-_40398286 0.076 NM_001003942
NM_001003943
BMF

Bcl2 modifying factor

chr22_+_31644314 0.076 NM_001031801
NM_016733
LIMK2

LIM domain kinase 2

chr1_-_152009490 0.075 NM_005620
S100A11
S100 calcium binding protein A11
chr10_+_75541804 0.075 NM_203298
CHCHD1
coiled-coil-helix-coiled-coil-helix domain containing 1
chr3_-_48471401 0.075 NM_001130082
PLXNB1
plexin B1
chr9_+_34179002 0.075 NM_001171201
NM_001171202
NM_001171203
NM_001171204
NM_016525
UBAP1




ubiquitin associated protein 1




chr20_+_2844688 0.075 NM_002836
PTPRA
VPS16
protein tyrosine phosphatase, receptor type, A
vacuolar protein sorting 16 homolog (S. cerevisiae)
chr19_+_57106622 0.075 NM_021216
ZNF71
zinc finger protein 71
chrY_+_148060 0.073 NM_018390
PLCXD1
phosphatidylinositol-specific phospholipase C, X domain containing 1
chr3_-_157221362 0.073 NM_001167915
NM_001167916
VEPH1

ventricular zone expressed PH domain homolog 1 (zebrafish)

chr10_+_104221158 0.071 NM_024789
TMEM180
transmembrane protein 180
chr3_-_56502364 0.071 NM_015576
ERC2
ELKS/RAB6-interacting/CAST family member 2
chr20_+_62526453 0.071 NM_025219
DNAJC5
DnaJ (Hsp40) homolog, subfamily C, member 5
chr1_+_203444955 0.071 PRELP
proline/arginine-rich end leucine-rich repeat protein
chr17_+_38137115 0.070 PSMD3
proteasome (prosome, macropain) 26S subunit, non-ATPase, 3
chr6_-_160679789 0.070 NM_003058
SLC22A2
solute carrier family 22 (organic cation transporter), member 2
chr17_-_63052707 0.070 GNA13
guanine nucleotide binding protein (G protein), alpha 13
chr3_+_33155559 0.069 CRTAP
cartilage associated protein
chr16_-_73092533 0.069 NM_001164766
ZFHX3
zinc finger homeobox 3
chr1_-_93257950 0.068 NM_005665
EVI5
ecotropic viral integration site 5
chr10_+_70883930 0.068 VPS26A
vacuolar protein sorting 26 homolog A (S. pombe)
chr3_+_115342302 0.068 GAP43
growth associated protein 43
chrX_-_107682600 0.067 NM_001847
COL4A6
collagen, type IV, alpha 6
chr14_-_21566497 0.066 ZNF219
zinc finger protein 219
chr15_-_40398573 0.066 NM_033503
BMF
Bcl2 modifying factor
chr20_-_44485953 0.065 NM_005469
ACOT8
acyl-CoA thioesterase 8
chr1_-_156470506 0.065 NM_005920
MEF2D
myocyte enhancer factor 2D
chr11_+_60989820 0.065 NM_001079808
PGA3
PGA4
pepsinogen 3, group I (pepsinogen A)
pepsinogen 4, group I (pepsinogen A)
chr2_-_113542970 0.064 NM_000575
IL1A
interleukin 1, alpha
chr1_+_157963062 0.064 NM_018240
KIRREL
kin of IRRE like (Drosophila)
chr19_-_48823331 0.064 NM_144577
CCDC114
coiled-coil domain containing 114
chr3_-_192445344 0.063 NM_004113
FGF12
fibroblast growth factor 12
chr17_+_38137053 0.062 NM_002809
PSMD3
proteasome (prosome, macropain) 26S subunit, non-ATPase, 3
chr17_-_63052744 0.061 GNA13
guanine nucleotide binding protein (G protein), alpha 13
chr14_+_60712469 0.061 NM_177952
PPM1A
protein phosphatase, Mg2+/Mn2+ dependent, 1A
chr14_-_64010063 0.060 NM_006246
PPP2R5E
protein phosphatase 2, regulatory subunit B', epsilon isoform
chr10_+_70883943 0.060 VPS26A
vacuolar protein sorting 26 homolog A (S. pombe)
chr17_+_38137088 0.060 PSMD3
proteasome (prosome, macropain) 26S subunit, non-ATPase, 3
chr2_-_25564745 0.060 NM_022552
DNMT3A
DNA (cytosine-5-)-methyltransferase 3 alpha
chr17_+_2497233 0.058 PAFAH1B1
platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)
chr10_+_70883987 0.058 VPS26A
vacuolar protein sorting 26 homolog A (S. pombe)
chr7_+_8473584 0.058 NM_152745
NXPH1
neurexophilin 1
chr3_-_131753757 0.058 NM_130808
CPNE4
copine IV
chr11_-_67407024 0.058 NM_005995
TBX10
T-box 10
chr20_+_36531498 0.057 NM_080607
VSTM2L
V-set and transmembrane domain containing 2 like
chr2_-_128439359 0.057 NM_001161404
LIMS2
LIM and senescent cell antigen-like domains 2
chr3_-_192126837 0.057 NM_021032
FGF12
fibroblast growth factor 12
chr18_+_63417487 0.056 NM_033646
CDH7
cadherin 7, type 2
chr11_+_10476665 0.056 NM_001025389
AMPD3
adenosine monophosphate deaminase 3
chr10_+_70883977 0.056 VPS26A
vacuolar protein sorting 26 homolog A (S. pombe)
chr5_+_152870083 0.056 NM_000827
NM_001114183
GRIA1

glutamate receptor, ionotropic, AMPA 1

chr13_-_28543290 0.054 NM_001265
CDX2
caudal type homeobox 2
chr2_-_25565352 0.054 DNMT3A
DNA (cytosine-5-)-methyltransferase 3 alpha
chr17_+_27573874 0.054 NM_005208
CRYBA1
crystallin, beta A1
chr19_+_13205956 0.054 NFIX
nuclear factor I/X (CCAAT-binding transcription factor)
chr12_+_46123495 0.054 NM_152641
ARID2
AT rich interactive domain 2 (ARID, RFX-like)
chr1_+_110168048 0.053 NM_203404
AMPD2
adenosine monophosphate deaminase 2
chr10_+_70883856 0.051 NM_001035260
NM_004896
VPS26A

vacuolar protein sorting 26 homolog A (S. pombe)


Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
3.05 2.79e-03 GO:0051094 positive regulation of developmental process
1.68 3.58e-03 GO:0048518 positive regulation of biological process
1.71 5.05e-03 GO:0048522 positive regulation of cellular process
1.94 7.51e-03 GO:0009653 anatomical structure morphogenesis
1.80 1.09e-02 GO:0048583 regulation of response to stimulus
2.30 1.68e-02 GO:0048584 positive regulation of response to stimulus
2.71 1.91e-02 GO:0032990 cell part morphogenesis
3.17 2.15e-02 GO:0045597 positive regulation of cell differentiation
3.30 2.16e-02 GO:0051130 positive regulation of cellular component organization
2.48 2.49e-02 GO:0032989 cellular component morphogenesis
2.80 2.74e-02 GO:0048812 neuron projection morphogenesis
2.51 2.90e-02 GO:0000902 cell morphogenesis
1.49 3.01e-02 GO:0023052 signaling
2.66 3.86e-02 GO:0031175 neuron projection development
2.63 4.56e-02 GO:0000904 cell morphogenesis involved in differentiation

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
3.82 1.66e-02 GO:0043025 neuronal cell body
3.71 2.20e-02 GO:0044297 cell body
2.29 3.11e-02 GO:0030054 cell junction

Nothing significant found in function category.