Motif ID: FOSL2.p2

Z-value: 1.440


Transcription factors associated with FOSL2.p2:

Gene SymbolEntrez IDGene Name
FOSL2 2355 FOS-like antigen 2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.p-valuePlot
FOSL2chr2_+_28616360-0.321.2e-01Click!


Activity profile for motif FOSL2.p2.

activity profile for motif FOSL2.p2


Sorted Z-values histogram for motif FOSL2.p2

Sorted Z-values for motif FOSL2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of FOSL2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr9_-_123688352 9.272 TRAF1
TNF receptor-associated factor 1
chr2_+_152214105 8.123 NM_007115
TNFAIP6
tumor necrosis factor, alpha-induced protein 6
chr15_+_67458492 7.900 NM_001145104
SMAD3
SMAD family member 3
chr4_+_74606222 6.375 NM_000584
IL8
interleukin 8
chr11_-_8739398 5.557 ST5
suppression of tumorigenicity 5
chr12_+_78225068 5.355 NM_014903
NAV3
neuron navigator 3
chr11_-_102668892 5.338 NM_001145938
NM_002421
MMP1

matrix metallopeptidase 1 (interstitial collagenase)

chr11_-_102668822 5.306 MMP1
matrix metallopeptidase 1 (interstitial collagenase)
chr21_+_43619798 5.271 NM_207627
NM_207628
ABCG1

ATP-binding cassette, sub-family G (WHITE), member 1

chr4_-_76957139 5.245 NM_005409
CXCL11
chemokine (C-X-C motif) ligand 11
chr15_+_89182038 5.046 NM_002201
ISG20
interferon stimulated exonuclease gene 20kDa
chr1_-_153521717 4.693 NM_002960
S100A3
S100 calcium binding protein A3
chr15_+_67418053 4.289 NM_001145102
SMAD3
SMAD family member 3
chr6_-_44233244 4.087 NFKBIE
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon
chr6_-_44233499 3.714 NM_004556
NFKBIE
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon
chr10_-_6019454 3.682 NM_002189
NM_172200
IL15RA

interleukin 15 receptor, alpha

chr16_+_57662301 3.671 NM_001145771
NM_001145772
NM_001145773
NM_201524
NM_201525
GPR56




G protein-coupled receptor 56




chrX_-_154563735 3.637 NM_001289
CLIC2
chloride intracellular channel 2
chr9_+_5510544 3.458 NM_025239
PDCD1LG2
programmed cell death 1 ligand 2
chr15_-_80263460 3.281 NM_001114735
NM_004049
BCL2A1

BCL2-related protein A1

chr11_-_72380107 3.191 NM_001146209
PDE2A
phosphodiesterase 2A, cGMP-stimulated
chr12_-_49259549 3.101 NM_014470
RND1
Rho family GTPase 1
chr10_+_104155431 2.999 NM_002502
NFKB2
nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
chr19_-_44174497 2.920 NM_001005376
NM_001005377
NM_002659
PLAUR


plasminogen activator, urokinase receptor


chr1_+_101185195 2.879 NM_001078
NM_001199834
NM_080682
VCAM1


vascular cell adhesion molecule 1


chr14_+_55221505 2.579 NM_001161577
SAMD4A
sterile alpha motif domain containing 4A
chr20_+_43343523 2.562 WISP2
WNT1 inducible signaling pathway protein 2
chr19_+_4229494 2.554 NM_005755
EBI3
Epstein-Barr virus induced 3
chr19_-_44174271 2.506 PLAUR
plasminogen activator, urokinase receptor
chr12_-_105322056 2.450 NM_032148
SLC41A2
solute carrier family 41, member 2
chr11_-_65430214 2.323 RELA
v-rel reticuloendotheliosis viral oncogene homolog A (avian)
chr6_+_83072922 2.252 NM_006670
TPBG
trophoblast glycoprotein
chr14_-_91710851 2.247 NM_001177676
GPR68
G protein-coupled receptor 68
chr9_+_103191795 2.191 NM_001198806
C9orf30
chromosome 9 open reading frame 30
chr1_-_6662681 2.161 KLHL21
kelch-like 21 (Drosophila)
chr1_-_1149495 2.101 NM_003327
TNFRSF4
tumor necrosis factor receptor superfamily, member 4
chr12_-_51403028 2.079 NM_001174130
SLC11A2
solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2
chr9_+_74920329 2.062


chr6_+_37252166 1.991 TBC1D22B
TBC1 domain family, member 22B
chr4_+_169013687 1.990 NM_007193
ANXA10
annexin A10
chr1_-_6662898 1.984 NM_014851
KLHL21
kelch-like 21 (Drosophila)
chr17_+_74381419 1.979 SPHK1
sphingosine kinase 1
chr10_-_6019880 1.928 NM_001243539
IL15RA
interleukin 15 receptor, alpha
chr17_+_74381186 1.896 NM_001142602
SPHK1
sphingosine kinase 1
chr17_+_79651035 1.890 HGS
hepatocyte growth factor-regulated tyrosine kinase substrate
chr2_+_102770401 1.881 NM_000877
IL1R1
interleukin 1 receptor, type I
chr18_+_55888838 1.839 NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like
chr18_+_55888799 1.828 NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like
chr5_+_35856990 1.819 NM_002185
IL7R
interleukin 7 receptor
chr1_+_205198058 1.810 NM_001242925
TMCC2
transmembrane and coiled-coil domain family 2
chr1_+_65613971 1.780 AK4
adenylate kinase 4
chr17_+_79650961 1.778 NM_004712
HGS
hepatocyte growth factor-regulated tyrosine kinase substrate
chr7_+_28448970 1.759 LOC401317
uncharacterized LOC401317
chr4_+_77953942 1.756 SEPT11
septin 11
chr1_-_209824641 1.717 NM_001017402
LAMB3
laminin, beta 3
chr21_-_35986744 1.688 NM_203417
RCAN1
regulator of calcineurin 1
chr2_+_69201704 1.684 NM_019617
GKN1
gastrokine 1
chr11_-_65430427 1.651 NM_001145138
NM_001243984
NM_001243985
NM_021975
RELA



v-rel reticuloendotheliosis viral oncogene homolog A (avian)



chr17_+_74380943 1.649 SPHK1
sphingosine kinase 1
chr3_+_11178778 1.638 NM_001098213
HRH1
histamine receptor H1
chr5_-_121413906 1.601 LOX
lysyl oxidase
chr18_+_61637262 1.594 NM_001031848
NM_002640
NM_198833
SERPINB8


serpin peptidase inhibitor, clade B (ovalbumin), member 8


chr7_-_98467615 1.575 TMEM130
transmembrane protein 130
chr7_-_98467483 1.575 TMEM130
transmembrane protein 130
chr5_-_121413967 1.537 LOX
lysyl oxidase
chr7_-_98467663 1.532 NM_001134450
NM_001134451
NM_152913
TMEM130


transmembrane protein 130


chr2_+_90077732 1.511


chr17_+_77030471 1.478 NM_198593
C1QTNF1
C1q and tumor necrosis factor related protein 1
chr9_-_69202203 1.469 NM_001085476
FOXD4L6
forkhead box D4-like 6
chr22_+_37309618 1.456 NM_000395
CSF2RB
colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)
chr1_+_156084458 1.436 NM_005572
NM_170707
NM_170708
LMNA


lamin A/C


chr7_-_1498961 1.425 MICALL2
MICAL-like 2
chr6_+_138188352 1.408 NM_006290
TNFAIP3
tumor necrosis factor, alpha-induced protein 3
chr4_-_122085475 1.408 NM_024873
TNIP3
TNFAIP3 interacting protein 3
chr1_+_183155393 1.389 LAMC2
laminin, gamma 2
chr18_+_55888750 1.352 NM_001144966
NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like
chr6_-_159239254 1.346 EZR
ezrin
chr16_-_11680146 1.339 NM_004862
LITAF
lipopolysaccharide-induced TNF factor
chr1_-_153935190 1.319 SLC39A1
solute carrier family 39 (zinc transporter), member 1
chr3_-_150480917 1.317 SIAH2
seven in absentia homolog 2 (Drosophila)
chr7_-_75623961 1.316 NM_031925
TMEM120A
transmembrane protein 120A
chr22_-_43343046 1.310 NM_007229
PACSIN2
protein kinase C and casein kinase substrate in neurons 2
chr16_-_1429612 1.302 NM_001193389
NM_023076
UNKL

unkempt homolog (Drosophila)-like

chr11_+_66742747 1.300 NM_001136485
C11orf86
chromosome 11 open reading frame 86
chr7_-_75623932 1.298 TMEM120A
transmembrane protein 120A
chr13_+_97794050 1.284 MBNL2
muscleblind-like 2 (Drosophila)
chr19_-_3969734 1.283 NM_001348
DAPK3
death-associated protein kinase 3
chr6_-_35888937 1.280 NM_003137
SRPK1
SRSF protein kinase 1
chr3_+_119187782 1.280 NM_152305
POGLUT1
protein O-glucosyltransferase 1
chr12_-_51402988 1.277 SLC11A2
solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2
chr7_+_150065330 1.273 REPIN1
replication initiator 1
chrX_-_110513750 1.262 NM_014289
CAPN6
calpain 6
chr21_-_37838724 1.259 NM_012130
CLDN14
claudin 14
chr3_-_150480963 1.254 NM_005067
SIAH2
seven in absentia homolog 2 (Drosophila)
chr17_+_7255427 1.250 KCTD11
potassium channel tetramerisation domain containing 11
chr12_+_100661158 1.243 SCYL2
SCY1-like 2 (S. cerevisiae)
chr6_-_84140854 1.242 NM_002395
ME1
malic enzyme 1, NADP(+)-dependent, cytosolic
chr2_-_219134795 1.238 AAMP
angio-associated, migratory cell protein
chr8_+_126442557 1.212 NM_025195
TRIB1
tribbles homolog 1 (Drosophila)
chr6_-_159239269 1.207 NM_003379
EZR
ezrin
chr1_+_183155361 1.207 LAMC2
laminin, gamma 2
chr6_+_106546736 1.203 NM_182907
PRDM1
PR domain containing 1, with ZNF domain
chr7_-_75623888 1.196 TMEM120A
transmembrane protein 120A
chr1_-_27816667 1.191 WASF2
WAS protein family, member 2
chr1_-_57045214 1.189 PPAP2B
phosphatidic acid phosphatase type 2B
chr2_-_219134865 1.171 NM_001087
AAMP
angio-associated, migratory cell protein
chr1_+_172389827 1.170 NM_139240
C1orf105
chromosome 1 open reading frame 105
chr16_+_83986826 1.157 NM_182981
OSGIN1
oxidative stress induced growth inhibitor 1
chr3_-_191048324 1.153 NM_198152
UTS2D
urotensin 2 domain containing
chr17_+_7255207 1.141 NM_001002914
KCTD11
potassium channel tetramerisation domain containing 11
chr6_-_159239198 1.110 EZR
ezrin
chr17_+_79651072 1.109 HGS
hepatocyte growth factor-regulated tyrosine kinase substrate
chr16_+_31044849 1.108 STX4
syntaxin 4
chr17_+_30771520 1.100 PSMD11
proteasome (prosome, macropain) 26S subunit, non-ATPase, 11
chr1_+_65613771 1.099 NM_013410
AK4
adenylate kinase 4
chr6_-_84140758 1.098 ME1
malic enzyme 1, NADP(+)-dependent, cytosolic
chr19_+_41949062 1.096 NM_001130514
C19orf69
chromosome 19 open reading frame 69
chr6_-_84140744 1.095 ME1
malic enzyme 1, NADP(+)-dependent, cytosolic
chr5_-_121414011 1.093 NM_002317
LOX
lysyl oxidase
chr6_-_134496833 1.079 SGK1
serum/glucocorticoid regulated kinase 1
chr3_-_150480887 1.077 SIAH2
seven in absentia homolog 2 (Drosophila)
chr1_+_150122415 1.076 PLEKHO1
pleckstrin homology domain containing, family O member 1
chr22_+_39916563 1.066 NM_001675
NM_182810
ATF4

activating transcription factor 4 (tax-responsive enhancer element B67)

chr9_+_42717233 1.054 NM_001099279
NM_199244
FOXD4L2
FOXD4L4
forkhead box D4-like 2
forkhead box D4-like 4
chr7_+_129932973 1.053 NM_001163446
NM_016352
CPA4

carboxypeptidase A4

chr11_+_12308446 1.049 NM_032867
MICALCL
MICAL C-terminal like
chr1_-_27816542 1.043 WASF2
WAS protein family, member 2
chr1_+_150122246 1.042 PLEKHO1
pleckstrin homology domain containing, family O member 1
chr1_+_183155173 1.042 NM_005562
NM_018891
LAMC2

laminin, gamma 2

chr17_+_21191347 1.026 NM_002756
MAP2K3
mitogen-activated protein kinase kinase 3
chr1_+_150122095 1.023 NM_016274
PLEKHO1
pleckstrin homology domain containing, family O member 1
chr10_+_81107259 1.023 PPIF
peptidylprolyl isomerase F
chr15_-_77712436 1.022 NM_024776
PEAK1
NKF3 kinase family member
chr1_-_57045129 1.021 PPAP2B
phosphatidic acid phosphatase type 2B
chr20_+_43343884 1.019 NM_003881
WISP2
WNT1 inducible signaling pathway protein 2
chr14_-_24777064 1.013


chr7_+_48128225 1.005 NM_181597
UPP1
uridine phosphorylase 1
chr20_-_1309809 0.993 NM_080489
SDCBP2
syndecan binding protein (syntenin) 2
chr16_+_31044881 0.991 NM_004604
STX4
syntaxin 4
chr14_-_61190458 0.983 NM_017420
SIX4
SIX homeobox 4
chr2_+_36923832 0.983 NM_001177969
NM_001177970
NM_001177971
NM_001177972
NM_053276
VIT




vitrin




chr1_-_57045235 0.981 NM_003713
PPAP2B
phosphatidic acid phosphatase type 2B
chr6_-_46293404 0.980 RCAN2
regulator of calcineurin 2
chr7_-_100487273 0.977 NM_001015072
UFSP1
UFM1-specific peptidase 1 (non-functional)
chr9_-_70178814 0.976 NM_001126334
FOXD4L5
forkhead box D4-like 5
chr17_-_34207308 0.964 NM_002985
CCL5
chemokine (C-C motif) ligand 5
chr7_-_1199785 0.959 ZFAND2A
zinc finger, AN1-type domain 2A
chr7_-_1199813 0.952 ZFAND2A
zinc finger, AN1-type domain 2A
chr1_-_244006471 0.934 NM_005465
NM_181690
AKT3

v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma)

chr6_-_35888816 0.934 SRPK1
SRSF protein kinase 1
chr17_-_41622727 0.933 ETV4
ets variant 4
chr16_+_31366519 0.932 ITGAX
integrin, alpha X (complement component 3 receptor 4 subunit)
chr1_-_27816676 0.930 NM_001201404
NM_006990
WASF2

WAS protein family, member 2

chr2_+_68872953 0.918 NM_138964
PROKR1
prokineticin receptor 1
chr17_+_21188021 0.913 MAP2K3
mitogen-activated protein kinase kinase 3
chr21_-_36421586 0.911 NM_001754
RUNX1
runt-related transcription factor 1
chrX_+_52112077 0.908 NM_130777
XAGE2
X antigen family, member 2
chr5_-_94417185 0.906 MCTP1
multiple C2 domains, transmembrane 1
chr1_+_156084541 0.905 LMNA
lamin A/C
chrX_-_52386995 0.897 NM_130777
XAGE2
X antigen family, member 2
chr17_+_41363845 0.887 NM_145041
TMEM106A
transmembrane protein 106A
chr16_+_89988416 0.877 NM_001197181
TUBB3
tubulin, beta 3 class III
chr6_-_84140651 0.870 ME1
malic enzyme 1, NADP(+)-dependent, cytosolic
chr1_+_155006281 0.867 NM_001143687
NM_152494
DCST1

DC-STAMP domain containing 1

chr17_-_33390676 0.854 NM_001017368
RFFL
ring finger and FYVE-like domain containing 1
chr5_-_149466173 0.854 CSF1R
colony stimulating factor 1 receptor
chr10_+_111765725 0.848 NM_019903
ADD3
adducin 3 (gamma)
chr6_+_29794743 0.843 NM_002127
HLA-G
major histocompatibility complex, class I, G
chr1_+_205473683 0.835 NM_002596
NM_212502
NM_212503
CDK18


cyclin-dependent kinase 18


chr7_+_143078457 0.827 ZYX
zyxin
chr2_-_152830448 0.827 NM_001005747
CACNB4
calcium channel, voltage-dependent, beta 4 subunit
chr10_-_81708860 0.827 NM_003019
SFTPD
surfactant protein D
chr17_+_79651042 0.825 HGS
hepatocyte growth factor-regulated tyrosine kinase substrate
chr2_+_201997687 0.823 NM_001202518
CFLAR
CASP8 and FADD-like apoptosis regulator
chr11_+_35639734 0.822 NM_014344
FJX1
four jointed box 1 (Drosophila)
chr12_+_100660846 0.819 SCYL2
SCY1-like 2 (S. cerevisiae)
chr2_-_219134846 0.813 AAMP
angio-associated, migratory cell protein
chr2_-_145275086 0.809 ZEB2
zinc finger E-box binding homeobox 2
chr6_-_35696359 0.808 NM_001145775
FKBP5
FK506 binding protein 5
chr6_-_138428477 0.803 NM_022121
PERP
PERP, TP53 apoptosis effector
chr12_+_69202796 0.801 MDM2
Mdm2 p53 binding protein homolog (mouse)
chr5_+_72143929 0.800 NM_153188
TNPO1
transportin 1
chr4_-_5828587 0.800 CRMP1
collapsin response mediator protein 1
chr14_+_58711599 0.798 PSMA3
proteasome (prosome, macropain) subunit, alpha type, 3
chr6_-_24877453 0.797 NM_015864
FAM65B
family with sequence similarity 65, member B
chr16_+_67022487 0.796 NM_173815
CES4A
carboxylesterase 4A
chr2_-_11484699 0.787 NM_004850
ROCK2
Rho-associated, coiled-coil containing protein kinase 2
chr16_+_57392694 0.784 NM_002990
CCL22
chemokine (C-C motif) ligand 22
chr1_-_935352 0.776 HES4
hairy and enhancer of split 4 (Drosophila)
chr4_-_170924911 0.775 NM_001009554
MFAP3L
microfibrillar-associated protein 3-like
chr2_+_127413739 0.772 GYPC
glycophorin C (Gerbich blood group)
chr12_+_56075329 0.766 NM_152637
METTL7B
methyltransferase like 7B
chr7_+_143078444 0.764 ZYX
zyxin
chr7_+_128095881 0.763 NM_001098786
NM_013332
HILPDA

hypoxia inducible lipid droplet-associated

chr17_-_38721701 0.761 NM_001838
CCR7
chemokine (C-C motif) receptor 7
chr16_+_67563539 0.760 NM_001193523
FAM65A
family with sequence similarity 65, member A
chr20_-_633808 0.759 SRXN1
sulfiredoxin 1
chr19_-_47735858 0.758 NM_001127240
NM_001127241
NM_001127242
BBC3


BCL2 binding component 3


chr20_+_43030005 0.756 HNF4A
hepatocyte nuclear factor 4, alpha
chr6_+_31553955 0.752 NM_205838
NM_205839
LST1

leukocyte specific transcript 1


Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.61 7.14e-05 GO:0002376 immune system process
1.71 2.06e-03 GO:0006955 immune response
2.65 1.63e-02 GO:0032496 response to lipopolysaccharide
1.62 1.76e-02 GO:0048584 positive regulation of response to stimulus
1.14 3.71e-02 GO:0065007 biological regulation
1.53 4.00e-02 GO:0042127 regulation of cell proliferation

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.20 3.81e-02 GO:0005886 plasma membrane

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.15 4.54e-03 GO:0005515 protein binding
2.33 3.84e-02 GO:0046873 metal ion transmembrane transporter activity