Motif ID: FOXD3.p2

Z-value: 0.826


Transcription factors associated with FOXD3.p2:

Gene SymbolEntrez IDGene Name
FOXD3 27022 forkhead box D3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.p-valuePlot
FOXD3chr1_+_637887290.145.2e-01Click!


Activity profile for motif FOXD3.p2.

activity profile for motif FOXD3.p2


Sorted Z-values histogram for motif FOXD3.p2

Sorted Z-values for motif FOXD3.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of FOXD3.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr4_+_41614725 2.954 LIMCH1
LIM and calponin homology domains 1
chr4_+_41614933 2.544 LIMCH1
LIM and calponin homology domains 1
chr1_+_84630575 2.452 NM_001242860
NM_001242861
PRKACB

protein kinase, cAMP-dependent, catalytic, beta

chr4_+_41614911 2.051 NM_001112719
NM_001112720
LIMCH1

LIM and calponin homology domains 1

chr9_-_74675498 1.415 NM_001128618
C9orf57
chromosome 9 open reading frame 57
chr1_+_84764048 1.280 NM_001010971
SAMD13
sterile alpha motif domain containing 13
chr1_-_57045235 1.275 NM_003713
PPAP2B
phosphatidic acid phosphatase type 2B
chr3_-_64211111 1.228 NM_198859
PRICKLE2
prickle homolog 2 (Drosophila)
chr21_-_27512668 1.216 NM_001136016
APP
amyloid beta (A4) precursor protein
chr3_+_46448678 1.173 NM_003965
NM_001130910
CCRL2

chemokine (C-C motif) receptor-like 2

chr21_-_31869427 1.146 NM_181610
KRTAP19-4
keratin associated protein 19-4
chr4_-_186577858 1.139 SORBS2
sorbin and SH3 domain containing 2
chr1_+_84630374 1.129 PRKACB
protein kinase, cAMP-dependent, catalytic, beta
chr1_+_84630014 1.128 NM_001242857
NM_001242858
NM_001242859
PRKACB


protein kinase, cAMP-dependent, catalytic, beta


chr4_-_90759446 1.090 NM_001146055
SNCA
synuclein, alpha (non A4 component of amyloid precursor)
chr5_-_111091947 1.057 NM_001142483
C5orf13
chromosome 5 open reading frame 13
chr2_+_109204777 1.048 LIMS1
LIM and senescent cell antigen-like domains 1
chr1_-_57045214 1.023 PPAP2B
phosphatidic acid phosphatase type 2B
chr4_-_186578122 0.935 NM_001145674
NM_001145675
SORBS2

sorbin and SH3 domain containing 2

chr5_-_10308167 0.899 NM_138809
CMBL
carboxymethylenebutenolidase homolog (Pseudomonas)
chr5_+_159614373 0.875 NM_001130958
FABP6
fatty acid binding protein 6, ileal
chr2_-_133429069 0.868 NM_001077427
LYPD1
LY6/PLAUR domain containing 1
chr1_-_57045129 0.837 PPAP2B
phosphatidic acid phosphatase type 2B
chr12_+_27175501 0.836 MED21
mediator complex subunit 21
chr6_+_26501448 0.833 NM_001732
BTN1A1
butyrophilin, subfamily 1, member A1
chr1_+_84609941 0.832 NM_182948
PRKACB
protein kinase, cAMP-dependent, catalytic, beta
chr18_-_22930826 0.815


chr16_+_81812897 0.807 NM_002661
PLCG2
phospholipase C, gamma 2 (phosphatidylinositol-specific)
chr20_+_19870209 0.801 NM_018993
RIN2
Ras and Rab interactor 2
chr9_-_14086901 0.777 NFIB
nuclear factor I/B
chr5_-_88179278 0.745 NM_001193350
NM_002397
MEF2C

myocyte enhancer factor 2C

chr5_-_997408 0.728 NM_001242737
LOC100506688
uncharacterized LOC100506688
chr2_+_12857885 0.724 TRIB2
tribbles homolog 2 (Drosophila)
chr9_+_79115548 0.718 NM_001097636
GCNT1
glucosaminyl (N-acetyl) transferase 1, core 2
chr16_+_81812899 0.717 PLCG2
phospholipase C, gamma 2 (phosphatidylinositol-specific)
chr4_-_187644983 0.701 NM_005245
FAT1
FAT tumor suppressor homolog 1 (Drosophila)
chr2_+_216176808 0.692 ATIC
5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase
chr8_+_74903563 0.692 NM_001195797
NM_015364
LY96

lymphocyte antigen 96

chr3_-_15839674 0.688 NM_001195098
ANKRD28
ankyrin repeat domain 28
chr8_-_80993009 0.672 NM_001025252
TPD52
tumor protein D52
chr1_-_77685076 0.645 NM_005482
PIGK
phosphatidylinositol glycan anchor biosynthesis, class K
chr17_-_34195745 0.640 NM_152781
C17orf66
chromosome 17 open reading frame 66
chr17_-_8424217 0.636 MYH10
myosin, heavy chain 10, non-muscle
chr2_-_32490688 0.636 NM_001199139
NM_021209
NLRC4

NLR family, CARD domain containing 4

chr9_-_75567915 0.632 ALDH1A1
aldehyde dehydrogenase 1 family, member A1
chr1_-_57044980 0.625 PPAP2B
phosphatidic acid phosphatase type 2B
chr2_-_80531486 0.624 NM_178839
LRRTM1
leucine rich repeat transmembrane neuronal 1
chr7_+_89783688 0.622 NM_012449
STEAP1
six transmembrane epithelial antigen of the prostate 1
chr12_+_48513012 0.610 NM_000289
PFKM
phosphofructokinase, muscle
chr15_-_55800431 0.609 NM_001033559
NM_001033560
NM_130810
DYX1C1


dyslexia susceptibility 1 candidate 1


chr1_+_164528586 0.603 NM_001204961
NM_001204963
NM_002585
PBX1


pre-B-cell leukemia homeobox 1


chr3_+_132036210 0.602 NM_001099
NM_001134194
ACPP

acid phosphatase, prostate

chr1_+_84768333 0.601 NM_001134664
SAMD13
sterile alpha motif domain containing 13
chr14_+_102276125 0.597 NM_002719
NM_178586
NM_178587
PPP2R5C


protein phosphatase 2, regulatory subunit B', gamma


chr6_+_142623364 0.596 GPR126
G protein-coupled receptor 126
chr7_-_120498128 0.591 NM_012338
TSPAN12
tetraspanin 12
chr2_+_216176818 0.591 ATIC
5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase
chrX_-_62570968 0.585 NM_001012968
SPIN4
spindlin family, member 4
chr2_+_216176678 0.581 NM_004044
ATIC
5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase
chr12_+_79258517 0.578 SYT1
synaptotagmin I
chr8_-_95274540 0.578 NM_005261
NM_181702
GEM

GTP binding protein overexpressed in skeletal muscle

chr9_+_127054246 0.572 NM_001166170
NM_001166171
NEK6

NIMA (never in mitosis gene a)-related kinase 6

chr20_+_19915716 0.567 RIN2
Ras and Rab interactor 2
chr19_-_39826676 0.566 NM_004877
GMFG
glia maturation factor, gamma
chr9_-_75568232 0.563 NM_000689
ALDH1A1
aldehyde dehydrogenase 1 family, member A1
chr12_+_56915587 0.562 NM_002898
RBMS2
RNA binding motif, single stranded interacting protein 2
chr12_+_79258448 0.560 NM_005639
SYT1
synaptotagmin I
chr2_+_109204745 0.551 NM_004987
LIMS1
LIM and senescent cell antigen-like domains 1
chr17_-_3182267 0.549 NM_002551
OR3A2
olfactory receptor, family 3, subfamily A, member 2
chr2_-_231989755 0.547 NM_000867
HTR2B
5-hydroxytryptamine (serotonin) receptor 2B
chr2_+_109204904 0.540 NM_001193488
LIMS1
LIM and senescent cell antigen-like domains 1
chr6_+_116832807 0.535 NM_153711
FAM26E
family with sequence similarity 26, member E
chr1_-_151345156 0.524 NM_003944
SELENBP1
selenium binding protein 1
chr7_+_6617035 0.514 NM_001134387
NM_001134388
NM_001134389
NM_018106
ZDHHC4



zinc finger, DHHC-type containing 4



chr10_+_71561687 0.512 COL13A1
collagen, type XIII, alpha 1
chr2_-_211341374 0.501 NM_001136574
NM_006055
NM_001136575
LANCL1


LanC lantibiotic synthetase component C-like 1 (bacterial)


chr8_-_27941387 0.492 NM_001010906
C8orf80
chromosome 8 open reading frame 80
chrX_-_24045302 0.485 NM_030624
KLHL15
kelch-like 15 (Drosophila)
chr15_+_96876568 0.481 NM_001145157
NR2F2
nuclear receptor subfamily 2, group F, member 2
chr13_-_78493902 0.479 NM_001201397
EDNRB
endothelin receptor type B
chr7_+_89783789 0.468 STEAP1
six transmembrane epithelial antigen of the prostate 1
chr8_+_86099909 0.463 NM_001083589
E2F5
E2F transcription factor 5, p130-binding
chr1_+_150480486 0.456 NM_001202858
NM_004425
NM_022664
ECM1


extracellular matrix protein 1


chr22_+_37678565 0.450 CYTH4
cytohesin 4
chr11_-_16996559 0.449 RPL36A
ribosomal protein L36a
chr5_-_88199868 0.440 NM_001131005
NM_001193347
MEF2C

myocyte enhancer factor 2C

chr4_-_186877869 0.439 NM_021069
SORBS2
sorbin and SH3 domain containing 2
chr6_-_159240398 0.436 EZR
ezrin
chr22_+_37678423 0.435 NM_013385
CYTH4
cytohesin 4
chrX_-_129272014 0.432 NM_001130846
AIFM1
apoptosis-inducing factor, mitochondrion-associated, 1
chr11_+_1718424 0.431 NM_001012416
KRTAP5-6
keratin associated protein 5-6
chr1_+_61547388 0.426 NM_001145512
NFIA
nuclear factor I/A
chr6_+_150263120 0.423 NM_025217
ULBP2
UL16 binding protein 2
chr9_+_75136716 0.423 NM_138691
TMC1
transmembrane channel-like 1
chr15_+_66585632 0.423 NM_133375
DIS3L
DIS3 mitotic control homolog (S. cerevisiae)-like
chr6_-_159240399 0.420 EZR
ezrin
chr3_+_132316080 0.420 NM_016557
CCRL1
chemokine (C-C motif) receptor-like 1
chr10_+_71561643 0.416 NM_001130103
NM_080798
NM_080800
NM_080801
NM_080802
NM_080805
COL13A1





collagen, type XIII, alpha 1





chr5_+_108083522 0.411 NM_005246
FER
fer (fps/fes related) tyrosine kinase
chr8_-_95274520 0.401 GEM
GTP binding protein overexpressed in skeletal muscle
chr12_+_27175482 0.396 NM_004264
MED21
mediator complex subunit 21
chr19_+_1026271 0.394 NM_004368
NM_201277
CNN2

calponin 2

chr14_-_21852085 0.393 SUPT16H
suppressor of Ty 16 homolog (S. cerevisiae)
chr2_+_233404436 0.393 NM_005199
CHRNG
cholinergic receptor, nicotinic, gamma
chr1_-_231560789 0.393 NM_022051
EGLN1
egl nine homolog 1 (C. elegans)
chr3_-_168864066 0.391 NM_001105077
NM_001163999
NM_005241
MECOM


MDS1 and EVI1 complex locus


chr19_-_49220213 0.389 NM_182574
MAMSTR
MEF2 activating motif and SAP domain containing transcriptional regulator
chr19_-_39322411 0.388 NM_001398
ECH1
enoyl CoA hydratase 1, peroxisomal
chr15_-_66648991 0.385 NM_017858
TIPIN
TIMELESS interacting protein
chr11_+_87032428 0.383 TMEM135
transmembrane protein 135
chr2_-_96150478 0.381 NM_001164464
TRIM43B
tripartite motif containing 43B
chr1_+_74701070 0.376 NM_015978
TNNI3K
TNNI3 interacting kinase
chr11_+_86085777 0.372 NM_001156474
NM_021827
CCDC81

coiled-coil domain containing 81

chr11_-_88070840 0.371 CTSC
cathepsin C
chr3_-_18480203 0.368 NM_001131010
SATB1
SATB homeobox 1
chr2_-_183387063 0.363 NM_005019
NM_001003683
PDE1A

phosphodiesterase 1A, calmodulin-dependent

chr4_-_186732208 0.363 NM_001145671
SORBS2
sorbin and SH3 domain containing 2
chr1_+_101185195 0.362 NM_001078
NM_001199834
NM_080682
VCAM1


vascular cell adhesion molecule 1


chr12_-_124068864 0.359


chr8_-_17579729 0.359 NM_001001931
MTUS1
microtubule associated tumor suppressor 1
chr2_-_158182154 0.358 NM_020711
ERMN
ermin, ERM-like protein
chr12_+_105153258 0.356 CHST11
carbohydrate (chondroitin 4) sulfotransferase 11
chr19_-_11689765 0.355 NM_001111035
NM_001111036
ACP5

acid phosphatase 5, tartrate resistant

chr14_+_102276279 0.355 PPP2R5C
protein phosphatase 2, regulatory subunit B', gamma
chr10_+_5238756 0.354 NM_001818
AKR1C4
aldo-keto reductase family 1, member C4 (chlordecone reductase; 3-alpha hydroxysteroid dehydrogenase, type I; dihydrodiol dehydrogenase 4)
chrX_-_2882288 0.350 NM_000047
ARSE
arylsulfatase E (chondrodysplasia punctata 1)
chr8_-_17658385 0.349 NM_001001924
NM_001001925
MTUS1

microtubule associated tumor suppressor 1

chr16_+_77756388 0.346 NM_001105663
NM_001243657
NM_001243660
NM_001243661
NUDT7



nudix (nucleoside diphosphate linked moiety X)-type motif 7



chr10_+_115310589 0.342 NM_001177660
HABP2
hyaluronan binding protein 2
chr4_-_102267952 0.342 PPP3CA
protein phosphatase 3, catalytic subunit, alpha isozyme
chr11_-_88070901 0.339 CTSC
cathepsin C
chr12_-_14996381 0.339 NM_021071
ART4
ADP-ribosyltransferase 4 (Dombrock blood group)
chrX_-_63005212 0.337 NM_001173479
ARHGEF9
Cdc42 guanine nucleotide exchange factor (GEF) 9
chr13_+_114239587 0.335 TFDP1
transcription factor Dp-1
chr14_-_61748193 0.334


chr2_-_119605758 0.332 NM_001426
EN1
engrailed homeobox 1
chr21_+_46293925 0.331


chr4_-_102268626 0.331 NM_000944
NM_001130691
NM_001130692
PPP3CA


protein phosphatase 3, catalytic subunit, alpha isozyme


chr12_-_8088629 0.329 NM_006931
SLC2A3
solute carrier family 2 (facilitated glucose transporter), member 3
chr12_+_20963637 0.329 NM_019844
SLCO1B3
solute carrier organic anion transporter family, member 1B3
chr2_-_80531716 0.326 LRRTM1
leucine rich repeat transmembrane neuronal 1
chr2_+_237478379 0.323 NM_020311
CXCR7
chemokine (C-X-C motif) receptor 7
chr16_-_28437663 0.323 NM_001199142
EIF3C
eukaryotic translation initiation factor 3, subunit C
chr12_+_54892567 0.323 NM_001184976
NCKAP1L
NCK-associated protein 1-like
chr15_+_42696957 0.319 NM_173089
NM_173090
CAPN3

calpain 3, (p94)

chr5_-_10307873 0.318 CMBL
carboxymethylenebutenolidase homolog (Pseudomonas)
chr3_-_151987332 0.318 LOC401093
uncharacterized LOC401093
chr1_+_84767288 0.314 NM_001134663
SAMD13
sterile alpha motif domain containing 13
chr5_+_139028483 0.313 CXXC5
CXXC finger protein 5
chr15_+_58430394 0.313 NM_020980
AQP9
aquaporin 9
chr16_+_28699878 0.313 NM_001199142
EIF3C
eukaryotic translation initiation factor 3, subunit C
chr2_-_165424993 0.313 GRB14
growth factor receptor-bound protein 14
chr20_-_5107185 0.312 NM_002592
PCNA
proliferating cell nuclear antigen
chrX_+_55744049 0.312 NM_006064
NM_016656
RRAGB

Ras-related GTP binding B

chr16_+_67381252 0.310 NM_001161575
LRRC36
leucine rich repeat containing 36
chr10_-_116286570 0.309 ABLIM1
actin binding LIM protein 1
chr13_+_97874704 0.308 MBNL2
muscleblind-like 2 (Drosophila)
chr1_-_114429996 0.306 BCL2L15
BCL2-like 15
chr13_+_103459495 0.305 NM_001204425
BIVM-ERCC5
BIVM
BIVM-ERCC5 readthrough
basic, immunoglobulin-like variable motif containing
chr1_+_164528914 0.305 PBX1
pre-B-cell leukemia homeobox 1
chr13_+_99058147 0.302


chr2_-_219031646 0.299 NM_000634
CXCR1
chemokine (C-X-C motif) receptor 1
chr3_-_149051258 0.298 NM_001184723
NM_138786
TM4SF18

transmembrane 4 L six family member 18

chr19_-_14785626 0.296 NM_032571
EMR3
egf-like module containing, mucin-like, hormone receptor-like 3
chr16_-_90076528 0.295 NM_024043
DBNDD1
dysbindin (dystrobrevin binding protein 1) domain containing 1
chr17_-_5138049 0.291 NM_207103
SCIMP
SLP adaptor and CSK interacting membrane protein
chr5_+_156696351 0.288 NM_014376
CYFIP2
cytoplasmic FMR1 interacting protein 2
chr2_-_113012601 0.287 NM_032494
ZC3H8
zinc finger CCCH-type containing 8
chr18_+_77160243 0.287 NM_172387
NM_172389
NFATC1

nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1

chr3_+_11267666 0.286 NM_001098211
HRH1
histamine receptor H1
chr9_-_14398981 0.286 NM_001190738
NFIB
nuclear factor I/B
chr10_+_225932 0.285 NM_001202467
NM_001202468
ZMYND11

zinc finger, MYND-type containing 11

chr2_+_96257765 0.285 NM_138800
TRIM43
tripartite motif containing 43
chr11_-_17191287 0.284 NM_002645
PIK3C2A
phosphoinositide-3-kinase, class 2, alpha polypeptide
chr19_+_36726883 0.283 ZNF146
zinc finger protein 146
chr22_+_25423940 0.283 NM_001145206
KIAA1671
KIAA1671
chr5_+_159436143 0.282 TTC1
tetratricopeptide repeat domain 1
chr9_+_27109138 0.282 NM_000459
TEK
TEK tyrosine kinase, endothelial
chr6_+_26104103 0.281 NM_003542
HIST2H4B
HIST1H4C
histone cluster 2, H4b
histone cluster 1, H4c
chr2_-_80531809 0.279 LRRTM1
leucine rich repeat transmembrane neuronal 1
chr17_+_67410825 0.278 NM_002758
MAP2K6
mitogen-activated protein kinase kinase 6
chr6_+_148664124 0.278 SASH1
SAM and SH3 domain containing 1
chr20_-_45985411 0.278 NM_012408
NM_183047
NM_183048
ZMYND8


zinc finger, MYND-type containing 8


chr15_+_49462408 0.276 NM_002044
GALK2
galactokinase 2
chr9_-_8733893 0.276 NM_001040712
NM_001171025
NM_130391
NM_130392
NM_130393
PTPRD




protein tyrosine phosphatase, receptor type, D




chr10_-_48390873 0.276 NM_002900
RBP3
retinol binding protein 3, interstitial
chr15_-_65321921 0.276 NM_139242
MTFMT
mitochondrial methionyl-tRNA formyltransferase
chr10_-_33623771 0.275 NM_001024628
NM_001024629
NM_001244972
NM_001244973
NM_003873
NRP1




neuropilin 1




chr1_+_36748164 0.274 THRAP3
thyroid hormone receptor associated protein 3
chr1_-_169703178 0.273 NM_000450
SELE
selectin E
chr14_-_81405883 0.273 NM_152446
CEP128
centrosomal protein 128kDa
chr9_-_116163578 0.271 NM_000031
ALAD
aminolevulinate dehydratase
chr17_+_61086897 0.269 NM_025185
TANC2
tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2
chr11_+_112047088 0.268 NM_001037290
BCO2
beta-carotene oxygenase 2
chr9_-_14314036 0.268 NM_001190737
NM_005596
NFIB

nuclear factor I/B

chr11_-_107582733 0.267 NM_003063
SLN
sarcolipin
chr1_+_109102970 0.266 NM_001010883
FAM102B
family with sequence similarity 102, member B
chr1_-_92371558 0.265 NM_001195684
TGFBR3
transforming growth factor, beta receptor III
chr16_+_11439279 0.262 NM_152308
RMI2
RMI2, RecQ mediated genome instability 2, homolog (S. cerevisiae)
chr16_+_4382224 0.262 NM_032575
GLIS2
GLIS family zinc finger 2

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.14 2.14e-02 GO:0043170 macromolecule metabolic process
1.11 5.00e-02 GO:0044238 primary metabolic process

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.10 2.33e-04 GO:0005737 cytoplasm
1.09 1.70e-03 GO:0043231 intracellular membrane-bounded organelle
1.09 2.20e-03 GO:0043227 membrane-bounded organelle
1.06 5.25e-03 GO:0005622 intracellular
1.06 6.16e-03 GO:0044424 intracellular part
1.07 7.19e-03 GO:0043229 intracellular organelle
1.07 1.10e-02 GO:0043226 organelle

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.06 8.93e-03 GO:0005488 binding
2.97 2.45e-02 GO:0003823 antigen binding