Motif ID: FOXL1.p2

Z-value: 0.808


Transcription factors associated with FOXL1.p2:

Gene SymbolEntrez IDGene Name
FOXL1 2300 forkhead box L1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.p-valuePlot
FOXL1chr16_+_86612114-0.232.7e-01Click!


Activity profile for motif FOXL1.p2.

activity profile for motif FOXL1.p2


Sorted Z-values histogram for motif FOXL1.p2

Sorted Z-values for motif FOXL1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of FOXL1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr19_+_39899749 6.010


chr4_-_16900028 3.519 LDB2
LIM domain binding 2
chr6_+_136172802 3.329 NM_018945
PDE7B
phosphodiesterase 7B
chr1_+_84630014 3.200 NM_001242857
NM_001242858
NM_001242859
PRKACB


protein kinase, cAMP-dependent, catalytic, beta


chr3_-_12941547 3.067 IQSEC1
IQ motif and Sec7 domain 1
chrX_-_117119282 2.823 NM_001168299
KLHL13
kelch-like 13 (Drosophila)
chr5_-_88119604 2.433 NM_001193348
NM_001193349
MEF2C

myocyte enhancer factor 2C

chrX_-_33229428 2.401 NM_004006
DMD
dystrophin
chr1_+_84768333 2.323 NM_001134664
SAMD13
sterile alpha motif domain containing 13
chr10_+_94594469 2.229 NM_001013848
EXOC6
exocyst complex component 6
chr9_-_74675498 2.218 NM_001128618
C9orf57
chromosome 9 open reading frame 57
chr2_+_132480063 2.040 NM_013310
C2orf27A
chromosome 2 open reading frame 27A
chr3_+_193853930 1.983 NM_005524
HES1
hairy and enhancer of split 1, (Drosophila)
chr1_+_78470593 1.868 NM_007034
DNAJB4
DnaJ (Hsp40) homolog, subfamily B, member 4
chr3_-_149051258 1.821 NM_001184723
NM_138786
TM4SF18

transmembrane 4 L six family member 18

chr7_+_89843133 1.768 NM_001040666
STEAP2
STEAP family member 2, metalloreductase
chr15_+_25281105 1.669 SNRPN
small nuclear ribonucleoprotein polypeptide N
chr3_+_193853937 1.644 HES1
hairy and enhancer of split 1, (Drosophila)
chr13_-_48987247 1.634 LPAR6
lysophosphatidic acid receptor 6
chr9_+_6215785 1.531 NM_001199640
NM_001199641
NM_033439
IL33


interleukin 33


chr13_-_48987017 1.510 LPAR6
lysophosphatidic acid receptor 6
chr4_+_41700736 1.395 LIMCH1
LIM and calponin homology domains 1
chr17_-_67138013 1.372 NM_080284
ABCA6
ATP-binding cassette, sub-family A (ABC1), member 6
chr4_+_88529680 1.352 NM_014208
DSPP
dentin sialophosphoprotein
chr4_-_138453628 1.322 NM_019035
PCDH18
protocadherin 18
chr10_-_116444112 1.271 ABLIM1
actin binding LIM protein 1
chr5_+_139505519 1.246 NM_001007189
IGIP
IgA-inducing protein homolog (Bos taurus)
chr10_-_116444374 1.205 NM_001003407
NM_001003408
ABLIM1

actin binding LIM protein 1

chr4_-_152149042 1.203 NM_001243349
SH3D19
SH3 domain containing 19
chr7_+_30951414 1.186 NM_198098
AQP1
aquaporin 1 (Colton blood group)
chrX_+_54947228 1.176 NM_001039705
NM_016157
NM_177556
TRO


trophinin


chr8_-_27941387 1.152 NM_001010906
C8orf80
chromosome 8 open reading frame 80
chr8_-_93029864 1.146 NM_175636
RUNX1T1
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
chr2_-_106055229 1.140 NM_201557
FHL2
four and a half LIM domains 2
chr10_+_35426709 1.138 NM_183011
NM_183012
CREM

cAMP responsive element modulator

chr13_-_48987652 1.135 NM_001162498
LPAR6
lysophosphatidic acid receptor 6
chr2_-_165424993 1.113 GRB14
growth factor receptor-bound protein 14
chr3_-_197300193 1.110 NM_203315
BDH1
3-hydroxybutyrate dehydrogenase, type 1
chr20_+_11898536 1.072 NM_014962
BTBD3
BTB (POZ) domain containing 3
chr11_+_7618416 1.070 PPFIBP2
PTPRF interacting protein, binding protein 2 (liprin beta 2)
chr15_-_77176191 1.060 NM_020843
SCAPER
S-phase cyclin A-associated protein in the ER
chr1_-_76076762 1.040 NM_001130058
NM_152697
SLC44A5

solute carrier family 44, member 5

chr15_-_70994608 1.030 NM_001008224
UACA
uveal autoantigen with coiled-coil domains and ankyrin repeats
chr11_-_71746966 1.018


chr9_-_13250313 1.008 NM_003829
MPDZ
multiple PDZ domain protein
chr1_+_212475147 1.005 NM_001199756
PPP2R5A
protein phosphatase 2, regulatory subunit B', alpha
chr5_-_111091947 0.995 NM_001142483
C5orf13
chromosome 5 open reading frame 13
chr13_+_50025687 0.980 NM_001160308
SETDB2
SET domain, bifurcated 2
chr10_+_102121371 0.971 SCD
stearoyl-CoA desaturase (delta-9-desaturase)
chr1_+_65730423 0.969 NM_014787
DNAJC6
DnaJ (Hsp40) homolog, subfamily C, member 6
chrX_+_102883647 0.959 NM_001006640
TCEAL1
transcription elongation factor A (SII)-like 1
chr9_-_75568232 0.914 NM_000689
ALDH1A1
aldehyde dehydrogenase 1 family, member A1
chr11_+_87032428 0.905 TMEM135
transmembrane protein 135
chr4_-_2230957 0.891 NM_181808
POLN
polymerase (DNA directed) nu
chr3_+_132318980 0.882 NM_178445
CCRL1
chemokine (C-C motif) receptor-like 1
chr8_-_8239188 0.881 NM_001080826
SGK223
homolog of rat pragma of Rnd2
chr2_+_33661392 0.871 NM_170672
RASGRP3
RAS guanyl releasing protein 3 (calcium and DAG-regulated)
chr10_-_116418056 0.858 NM_002313
ABLIM1
actin binding LIM protein 1
chrX_-_135863502 0.850 NM_004840
ARHGEF6
Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
chr5_-_9630462 0.841 NM_019599
TAS2R1
taste receptor, type 2, member 1
chr7_+_22767101 0.837 IL6
interleukin 6 (interferon, beta 2)
chr5_+_42548144 0.830 NM_001242402
GHR
growth hormone receptor
chr8_-_82395401 0.817 NM_001442
FABP4
fatty acid binding protein 4, adipocyte
chr13_+_111855406 0.806 ARHGEF7
Rho guanine nucleotide exchange factor (GEF) 7
chr1_+_164818083 0.790 PBX1
pre-B-cell leukemia homeobox 1
chr3_+_132316080 0.788 NM_016557
CCRL1
chemokine (C-C motif) receptor-like 1
chr3_-_112359863 0.782 CCDC80
coiled-coil domain containing 80
chr9_-_75567915 0.776 ALDH1A1
aldehyde dehydrogenase 1 family, member A1
chr6_-_76203256 0.773 NM_015687
FILIP1
filamin A interacting protein 1
chr14_+_21525980 0.768 NM_138331
RNASE8
ribonuclease, RNase A family, 8
chr1_+_84767288 0.762 NM_001134663
SAMD13
sterile alpha motif domain containing 13
chr3_+_113616317 0.748 NM_001172105
GRAMD1C
GRAM domain containing 1C
chr2_-_99279935 0.736 NM_001160154
MGAT4A
mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A
chr17_-_67240955 0.736 NM_080282
ABCA10
ATP-binding cassette, sub-family A (ABC1), member 10
chr2_+_189839078 0.721 NM_000090
COL3A1
collagen, type III, alpha 1
chr10_+_35484829 0.715 NM_182721
NM_182722
NM_182723
NM_182724
NM_182725
CREM




cAMP responsive element modulator




chr2_-_188312872 0.715 NM_005795
CALCRL
calcitonin receptor-like
chr12_-_9268513 0.711 A2M
alpha-2-macroglobulin
chr5_+_61874561 0.706 NM_181506
LRRC70
leucine rich repeat containing 70
chr15_+_41221530 0.703 NM_019074
DLL4
delta-like 4 (Drosophila)
chr10_-_97200895 0.692 NM_001034954
NM_001034955
NM_001034956
NM_001034957
NM_006434
SORBS1




sorbin and SH3 domain containing 1




chr2_+_33738941 0.688 NM_015376
RASGRP3
RAS guanyl releasing protein 3 (calcium and DAG-regulated)
chr14_-_22005035 0.684 NM_005407
SALL2
sal-like 2 (Drosophila)
chr17_+_38119225 0.680 NM_178171
GSDMA
gasdermin A
chr4_-_110723127 0.677 CFI
complement factor I
chr12_-_71031174 0.677 NM_001109754
PTPRB
protein tyrosine phosphatase, receptor type, B
chr12_-_53189780 0.676 NM_057088
KRT3
keratin 3
chr18_+_8717368 0.675 NM_015210
CCDC165
coiled-coil domain containing 165
chr8_+_1993157 0.671 NM_003970
MYOM2
myomesin (M-protein) 2, 165kDa
chr11_-_7818488 0.667 NM_153444
OR5P2
olfactory receptor, family 5, subfamily P, member 2
chr1_+_84630575 0.660 NM_001242860
NM_001242861
PRKACB

protein kinase, cAMP-dependent, catalytic, beta

chr11_+_99426872 0.656 NM_175566
CNTN5
contactin 5
chr5_+_42548314 0.653 NM_001242403
GHR
growth hormone receptor
chr13_+_103459495 0.650 NM_001204425
BIVM-ERCC5
BIVM
BIVM-ERCC5 readthrough
basic, immunoglobulin-like variable motif containing
chr5_-_88199868 0.640 NM_001131005
NM_001193347
MEF2C

myocyte enhancer factor 2C

chr1_+_196621007 0.638 NM_000186
NM_001014975
CFH

complement factor H

chr6_+_147527102 0.634 STXBP5
syntaxin binding protein 5 (tomosyn)
chr12_-_9268522 0.630 NM_000014
A2M
alpha-2-macroglobulin
chr7_+_22766765 0.621 NM_000600
IL6
interleukin 6 (interferon, beta 2)
chr14_+_21156922 0.603 NM_001097577
NM_194431
ANG
RNASE4
angiogenin, ribonuclease, RNase A family, 5
ribonuclease, RNase A family, 4
chr1_+_84609941 0.602 NM_182948
PRKACB
protein kinase, cAMP-dependent, catalytic, beta
chr11_+_65266642 0.601


chr1_+_367639 0.600 NM_001005224
NM_001005221
NM_001005277
OR4F3
OR4F29
OR4F16
olfactory receptor, family 4, subfamily F, member 3
olfactory receptor, family 4, subfamily F, member 29
olfactory receptor, family 4, subfamily F, member 16
chr18_+_29769986 0.597 NM_005925
MEP1B
meprin A, beta
chr2_-_198540583 0.595 NM_144629
RFTN2
raftlin family member 2
chrX_-_10535476 0.593 NM_001193278
NM_001193279
NM_001193280
NM_001193281
MID1



midline 1 (Opitz/BBB syndrome)



chr12_+_32654976 0.593 NM_139241
FGD4
FYVE, RhoGEF and PH domain containing 4
chr1_+_196788860 0.586 NM_002113
CFHR1
complement factor H-related 1
chr8_-_102803196 0.583 NCALD
neurocalcin delta
chr15_+_57511616 0.582 NM_207040
TCF12
transcription factor 12
chr14_+_100563817 0.581 EVL
Enah/Vasp-like
chr12_-_9268475 0.575 A2M
alpha-2-macroglobulin
chr3_-_112359962 0.575 NM_199511
NM_199512
CCDC80

coiled-coil domain containing 80

chr3_-_58200397 0.574 NM_004944
DNASE1L3
deoxyribonuclease I-like 3
chr1_+_97260515 0.565


chr2_-_170430312 0.561 NM_024622
FASTKD1
FAST kinase domains 1
chr9_+_127119114 0.550


chr10_+_57358749 0.545 NM_001190478
MTRNR2L5
MT-RNR2-like 5
chr5_+_140739589 0.544 NM_018923
NM_032096
PCDHGB2

protocadherin gamma subfamily B, 2

chr19_+_45971249 0.544 NM_001114171
NM_006732
FOSB

FBJ murine osteosarcoma viral oncogene homolog B

chr17_+_18647325 0.539 NM_031456
FBXW10
F-box and WD repeat domain containing 10
chr2_-_43453737 0.538 NM_006887
ZFP36L2
zinc finger protein 36, C3H type-like 2
chrX_-_57164057 0.530 NM_019003
SPIN2A
spindlin family, member 2A
chr16_-_31439650 0.525 NM_005205
COX6A2
cytochrome c oxidase subunit VIa polypeptide 2
chr7_+_80267782 0.524 NM_000072
NM_001001548
CD36

CD36 molecule (thrombospondin receptor)

chr9_+_71944240 0.523 NM_004816
FAM189A2
family with sequence similarity 189, member A2
chr11_-_17191287 0.520 NM_002645
PIK3C2A
phosphoinositide-3-kinase, class 2, alpha polypeptide
chr9_+_79093256 0.517 NM_001097635
GCNT1
glucosaminyl (N-acetyl) transferase 1, core 2
chr9_-_14398981 0.516 NM_001190738
NFIB
nuclear factor I/B
chr1_+_163038564 0.516 NM_005613
RGS4
regulator of G-protein signaling 4
chr12_-_9268440 0.515 A2M
alpha-2-macroglobulin
chr15_+_67841341 0.510 NM_001206804
MAP2K5
mitogen-activated protein kinase kinase 5
chr4_-_16900348 0.509 NM_001130834
NM_001290
LDB2

LIM domain binding 2

chr10_+_89267589 0.505 NM_001178118
MINPP1
multiple inositol-polyphosphate phosphatase 1
chrX_+_107683015 0.505 NM_000495
NM_033380
COL4A5

collagen, type IV, alpha 5

chrX_+_54834107 0.501 NM_177433
MAGED2
melanoma antigen family D, 2
chr10_-_116392099 0.497 ABLIM1
actin binding LIM protein 1
chr14_-_20774129 0.496 NM_138376
TTC5
tetratricopeptide repeat domain 5
chr16_-_49860917 0.494 NM_015069
ZNF423
zinc finger protein 423
chr1_+_41204509 0.493 NFYC
nuclear transcription factor Y, gamma
chr1_+_145524989 0.486 NM_003637
ITGA10
integrin, alpha 10
chr9_+_21409132 0.484 NM_002170
IFNA8
interferon, alpha 8
chr8_+_74903563 0.479 NM_001195797
NM_015364
LY96

lymphocyte antigen 96

chr4_-_16900256 0.473 LDB2
LIM domain binding 2
chr4_+_113739203 0.470 NM_001127493
ANK2
ankyrin 2, neuronal
chr4_-_159093717 0.468 NM_016613
FAM198B
family with sequence similarity 198, member B
chr18_+_33234532 0.467 NM_020474
GALNT1
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 1 (GalNAc-T1)
chr14_+_64680858 0.465 NM_182913
SYNE2
spectrin repeat containing, nuclear envelope 2
chr6_+_144612872 0.463 NM_007124
UTRN
utrophin
chr3_-_69037498 0.462 C3orf64
chromosome 3 open reading frame 64
chr7_+_150690838 0.460 NM_001160109
NM_001160110
NM_001160111
NOS3


nitric oxide synthase 3 (endothelial cell)


chr1_+_163038395 0.457 NM_001102445
RGS4
regulator of G-protein signaling 4
chr16_+_82068910 0.454 HSD17B2
hydroxysteroid (17-beta) dehydrogenase 2
chr5_+_68800003 0.450 NM_001205255
OCLN
occludin
chr14_-_23285011 0.450 NM_001126105
SLC7A7
solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
chr6_-_112575708 0.450 LAMA4
laminin, alpha 4
chr5_+_53751430 0.446 NM_006308
HSPB3
heat shock 27kDa protein 3
chr12_+_60083125 0.442 NM_004731
SLC16A7
solute carrier family 16, member 7 (monocarboxylic acid transporter 2)
chr1_-_622033 0.441 NM_001005224
NM_001005221
NM_001005277
OR4F3
OR4F29
OR4F16
olfactory receptor, family 4, subfamily F, member 3
olfactory receptor, family 4, subfamily F, member 29
olfactory receptor, family 4, subfamily F, member 16
chr7_+_142919129 0.436 NM_176882
TAS2R40
taste receptor, type 2, member 40
chr1_+_244214576 0.436 ZNF238
zinc finger protein 238
chr19_+_39155209 0.434


chr1_+_115572414 0.432 NM_000549
TSHB
thyroid stimulating hormone, beta
chr3_-_17782398 0.427 NM_014744
TBC1D5
TBC1 domain family, member 5
chr17_-_48945338 0.424 NM_001243877
TOB1
transducer of ERBB2, 1
chr10_-_91405320 0.424 NM_148977
PANK1
pantothenate kinase 1
chr7_+_116660291 0.417 ST7
suppression of tumorigenicity 7
chr3_-_74570262 0.413 NM_020872
CNTN3
contactin 3 (plasmacytoma associated)
chr13_-_49001042 0.412 NM_001162497
LPAR6
lysophosphatidic acid receptor 6
chr10_+_35464514 0.408 NM_182769
NM_182770
CREM

cAMP responsive element modulator

chr16_+_20775311 0.403 NM_005622
NM_202000
ACSM3

acyl-CoA synthetase medium-chain family member 3

chr11_+_20620945 0.400 NM_004211
SLC6A5
solute carrier family 6 (neurotransmitter transporter, glycine), member 5
chr6_-_22297729 0.396 NM_000948
PRL
prolactin
chr11_+_92085261 0.392 NM_001008781
FAT3
FAT tumor suppressor homolog 3 (Drosophila)
chr6_-_112575766 0.391 NM_001105206
NM_001105207
NM_001105208
NM_001105209
NM_002290
LAMA4




laminin, alpha 4




chr12_-_6055397 0.391 NM_020373
ANO2
anoctamin 2
chr15_-_77154284 0.389 NM_001145923
SCAPER
S-phase cyclin A-associated protein in the ER
chr18_+_6834431 0.387 NM_001010000
ARHGAP28
Rho GTPase activating protein 28
chr8_-_102803438 0.385 NM_032041
NCALD
neurocalcin delta
chr1_-_110933635 0.383 SLC16A4
solute carrier family 16, member 4 (monocarboxylic acid transporter 5)
chr17_-_54893249 0.381 NM_001085430
C17orf67
chromosome 17 open reading frame 67
chr9_-_3223007 0.377


chr4_-_138453564 0.377 PCDH18
protocadherin 18
chr17_-_8063946 0.374 VAMP2
vesicle-associated membrane protein 2 (synaptobrevin 2)
chr15_+_40509628 0.372 NM_001128628
NM_001128629
PAK6

p21 protein (Cdc42/Rac)-activated kinase 6

chr3_-_158390266 0.372 NM_020169
LXN
latexin
chr2_-_37297372 0.371 HEATR5B
HEAT repeat containing 5B
chr2_+_38155901 0.369 NM_001170792
FAM82A1
family with sequence similarity 82, member A1
chr10_+_5488521 0.369 NM_005863
NET1
neuroepithelial cell transforming 1
chr1_-_168513201 0.368 NM_003175
XCL1
XCL2
chemokine (C motif) ligand 1
chemokine (C motif) ligand 2
chr20_-_1472004 0.365 SIRPB2
signal-regulatory protein beta 2
chr9_-_14086901 0.364 NFIB
nuclear factor I/B
chr9_+_124048396 0.362 GSN
gelsolin
chr17_+_76000248 0.361 NM_001142640
NM_018996
TNRC6C

trinucleotide repeat containing 6C

chr12_-_15038724 0.360 NM_000900
NM_001190839
MGP

matrix Gla protein

chr18_-_53071225 0.359 NM_001243232
TCF4
transcription factor 4
chr8_+_98703361 0.354 MTDH
metadherin
chr19_-_38916801 0.353 NM_001146202
NM_001146203
NM_001146204
NM_001146205
NM_001146206
NM_001146207
NM_170604
RASGRP4






RAS guanyl releasing protein 4






chrX_-_31526414 0.351 NM_004014
DMD
dystrophin
chr10_+_35456443 0.350 NM_182771
NM_182772
CREM

cAMP responsive element modulator


Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.27 4.40e-04 GO:0032501 multicellular organismal process
3.28 1.59e-03 GO:0007156 homophilic cell adhesion
4.34 2.87e-02 GO:0002526 acute inflammatory response
1.74 3.26e-02 GO:0007155 cell adhesion
1.74 3.26e-02 GO:0022610 biological adhesion
2.28 3.34e-02 GO:0006954 inflammatory response
1.99 3.35e-02 GO:0050776 regulation of immune response
2.24 3.39e-02 GO:0016337 cell-cell adhesion
1.66 4.83e-02 GO:0009611 response to wounding

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.61 1.69e-07 GO:0005576 extracellular region
1.90 3.17e-07 GO:0044421 extracellular region part
1.86 8.34e-05 GO:0005615 extracellular space
1.27 1.99e-03 GO:0071944 cell periphery
1.26 3.91e-03 GO:0005886 plasma membrane
2.11 1.31e-02 GO:0005578 proteinaceous extracellular matrix
1.35 2.76e-02 GO:0044459 plasma membrane part
1.95 3.08e-02 GO:0031012 extracellular matrix

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.60 2.01e-02 GO:0030234 enzyme regulator activity