Motif ID: FOXN1.p2

Z-value: 0.979


Transcription factors associated with FOXN1.p2:

Gene SymbolEntrez IDGene Name
FOXN1 8456 forkhead box N1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.p-valuePlot
FOXN1chr17_+_26850958-0.232.7e-01Click!


Activity profile for motif FOXN1.p2.

activity profile for motif FOXN1.p2


Sorted Z-values histogram for motif FOXN1.p2

Sorted Z-values for motif FOXN1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of FOXN1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr1_+_101361649 2.175 SLC30A7
solute carrier family 30 (zinc transporter), member 7
chr1_+_101361688 1.531 SLC30A7
solute carrier family 30 (zinc transporter), member 7
chr8_+_86089618 1.530 NM_001083588
NM_001951
E2F5

E2F transcription factor 5, p130-binding

chr6_-_137113166 1.380


chr3_-_120461350 1.228


chr2_-_54198055 1.197


chr8_-_8750739 1.145 NM_004225
MFHAS1
malignant fibrous histiocytoma amplified sequence 1
chr9_-_99775855 1.089 HIATL2
hippocampus abundant transcript-like 2
chr13_+_24734788 1.045 NM_001166271
NM_153023
SPATA13

spermatogenesis associated 13

chr1_+_12040475 1.033 MFN2
mitofusin 2
chr3_-_120461362 1.023 NM_173825
RABL3
RAB, member of RAS oncogene family-like 3
chr1_+_178063302 1.013 RASAL2
RAS protein activator like 2
chr2_+_68694669 0.987 NM_173545
APLF
aprataxin and PNKP like factor
chr7_-_22396511 0.976 NM_012294
RAPGEF5
Rap guanine nucleotide exchange factor (GEF) 5
chr1_-_184943532 0.966 FAM129A
family with sequence similarity 129, member A
chr16_-_75498231 0.960 TMEM170A
transmembrane protein 170A
chr16_+_50776012 0.909 NM_001042412
CYLD
cylindromatosis (turban tumor syndrome)
chr6_-_137113529 0.891 MAP3K5
mitogen-activated protein kinase kinase kinase 5
chr1_+_227058241 0.882 NM_000447
NM_012486
PSEN2

presenilin 2 (Alzheimer disease 4)

chr16_-_75498497 0.871 TMEM170A
transmembrane protein 170A
chrX_+_68048792 0.850 NM_004429
EFNB1
ephrin-B1
chr9_+_82187469 0.847 TLE4
transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)
chr1_-_184943673 0.844 NM_052966
FAM129A
family with sequence similarity 129, member A
chr1_+_178063237 0.838 RASAL2
RAS protein activator like 2
chr5_+_179247841 0.837 NM_003900
SQSTM1
sequestosome 1
chr1_+_28995214 0.824 NM_006582
NM_024482
GMEB1

glucocorticoid modulatory element binding protein 1

chr12_-_6716475 0.787 CHD4
chromodomain helicase DNA binding protein 4
chr5_+_179248089 0.779 SQSTM1
sequestosome 1
chr6_-_137113602 0.762 MAP3K5
mitogen-activated protein kinase kinase kinase 5
chr14_+_70078313 0.748 KIAA0247
KIAA0247
chr16_+_50775960 0.740 NM_001042355
NM_015247
CYLD

cylindromatosis (turban tumor syndrome)

chr2_-_165697927 0.731 NM_014900
COBLL1
COBL-like 1
chr5_+_179247903 0.729 SQSTM1
sequestosome 1
chr16_+_31044849 0.725 STX4
syntaxin 4
chr1_+_101361671 0.723 SLC30A7
solute carrier family 30 (zinc transporter), member 7
chr16_-_75498582 0.722 NM_145254
TMEM170A
transmembrane protein 170A
chr6_-_137113721 0.716 MAP3K5
mitogen-activated protein kinase kinase kinase 5
chr15_-_101835404 0.712 NM_003090
SNRPA1
small nuclear ribonucleoprotein polypeptide A'
chr12_-_12715244 0.692 NM_030640
DUSP16
dual specificity phosphatase 16
chr9_+_33025270 0.691 DNAJA1
DnaJ (Hsp40) homolog, subfamily A, member 1
chr15_-_40213087 0.688 NM_007223
GPR176
G protein-coupled receptor 176
chr14_-_51134862 0.679 SAV1
salvador homolog 1 (Drosophila)
chr9_+_33025207 0.675 NM_001539
DNAJA1
DnaJ (Hsp40) homolog, subfamily A, member 1
chr5_+_179247911 0.665 SQSTM1
sequestosome 1
chr9_+_33025302 0.664 DNAJA1
DnaJ (Hsp40) homolog, subfamily A, member 1
chr15_+_71184781 0.662 NM_001199017
NM_017691
NM_001199018
LRRC49


leucine rich repeat containing 49


chr1_-_235491448 0.655 ARID4B
AT rich interactive domain 4B (RBP1-like)
chr5_+_179233351 0.650 NM_001142298
SQSTM1
sequestosome 1
chr15_-_59665053 0.641 MYO1E
myosin IE
chr6_-_31324898 0.640 HLA-B
major histocompatibility complex, class I, B
chr9_-_115095786 0.634 PTBP3
polypyrimidine tract binding protein 3
chr20_-_47894591 0.630 NM_021035
ZNFX1
zinc finger, NFX1-type containing 1
chr8_-_22926490 0.618 NM_003842
NM_147187
TNFRSF10B

tumor necrosis factor receptor superfamily, member 10b

chr16_-_57318452 0.617 PLLP
plasmolipin
chr15_-_59665069 0.607 NM_004998
MYO1E
myosin IE
chr16_-_57318574 0.606 NM_015993
PLLP
plasmolipin
chr1_-_236445084 0.603 ERO1LB
ERO1-like beta (S. cerevisiae)
chr16_+_31044881 0.603 NM_004604
STX4
syntaxin 4
chr14_+_70078309 0.602 NM_014734
KIAA0247
KIAA0247
chr5_+_99871234 0.593 FAM174A
family with sequence similarity 174, member A
chr4_+_103422553 0.593 NFKB1
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
chr1_+_101361589 0.592 NM_001144884
NM_133496
SLC30A7

solute carrier family 30 (zinc transporter), member 7

chr15_+_52311438 0.591 MAPK6
mitogen-activated protein kinase 6
chr8_+_17104384 0.582 NM_001145152
NM_152415
VPS37A

vacuolar protein sorting 37 homolog A (S. cerevisiae)

chr6_-_31324955 0.579 HLA-B
major histocompatibility complex, class I, B
chr9_-_115095933 0.575 NM_001163788
NM_001163790
NM_001244896
NM_001244897
NM_005156
PTBP3




polypyrimidine tract binding protein 3




chr14_-_53417272 0.575 FERMT2
fermitin family member 2
chrX_-_48815582 0.571 OTUD5
OTU domain containing 5
chr10_+_103911932 0.563 NM_004741
NOLC1
nucleolar and coiled-body phosphoprotein 1
chr15_+_76135992 0.557 UBE2Q2
ubiquitin-conjugating enzyme E2Q family member 2
chr17_+_28705960 0.554 CPD
carboxypeptidase D
chr17_-_49198084 0.553 NM_001130527
NM_001130528
NM_003971
SPAG9


sperm associated antigen 9


chr1_-_47082529 0.552 NM_201403
MOB3C
MOB kinase activator 3C
chr5_-_95297597 0.541 NM_012081
ELL2
elongation factor, RNA polymerase II, 2
chrX_-_40506666 0.538 CXorf38
chromosome X open reading frame 38
chr4_-_2757750 0.529 NM_001161527
TNIP2
TNFAIP3 interacting protein 2
chr14_-_51135021 0.523 NM_021818
SAV1
salvador homolog 1 (Drosophila)
chr15_+_52311408 0.521 NM_002748
MAPK6
mitogen-activated protein kinase 6
chr6_-_137113624 0.520 NM_005923
MAP3K5
mitogen-activated protein kinase kinase kinase 5
chr9_+_97136817 0.515 NM_032558
HIATL1
hippocampus abundant transcript-like 1
chr15_+_93447702 0.514 CHD2
chromodomain helicase DNA binding protein 2
chr12_+_32259655 0.512 BICD1
bicaudal D homolog 1 (Drosophila)
chr9_+_82187599 0.508 TLE4
transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)
chr1_-_12677347 0.507 NM_004753
DHRS3
dehydrogenase/reductase (SDR family) member 3
chr4_+_103422479 0.504 NM_001165412
NM_003998
NFKB1

nuclear factor of kappa light polypeptide gene enhancer in B-cells 1

chr3_-_195808980 0.503 TFRC
transferrin receptor (p90, CD71)
chr8_+_86089641 0.502


chr16_-_31085073 0.496 ZNF668
zinc finger protein 668
chr14_-_50999178 0.490 NM_006575
NM_198794
MAP4K5

mitogen-activated protein kinase kinase kinase kinase 5

chr10_+_70715883 0.488 NM_004728
DDX21
DEAD (Asp-Glu-Ala-Asp) box polypeptide 21
chr5_+_151151483 0.485 G3BP1
GTPase activating protein (SH3 domain) binding protein 1
chr6_+_29691203 0.484 HLA-F
major histocompatibility complex, class I, F
chr10_+_5726781 0.483 NM_017782
FAM208B
family with sequence similarity 208, member B
chr5_-_137090049 0.483


chr2_-_175869910 0.482 NM_001822
NM_001025201
CHN1

chimerin (chimaerin) 1

chr10_+_91174438 0.482 IFIT5
interferon-induced protein with tetratricopeptide repeats 5
chr20_-_47894570 0.481 ZNFX1
zinc finger, NFX1-type containing 1
chr10_-_6019454 0.475 NM_002189
NM_172200
IL15RA

interleukin 15 receptor, alpha

chr20_-_3996035 0.471 NM_007219
NM_001134337
NM_001134338
RNF24


ring finger protein 24


chr7_+_6144504 0.470 NM_032172
USP42
ubiquitin specific peptidase 42
chr13_-_73356058 0.465 DIS3
DIS3 mitotic control homolog (S. cerevisiae)
chr16_+_31191461 0.462 FUS
fused in sarcoma
chr11_-_65430214 0.451 RELA
v-rel reticuloendotheliosis viral oncogene homolog A (avian)
chr2_-_202507348 0.450 NM_152388
TMEM237
transmembrane protein 237
chr1_+_178062955 0.444 RASAL2
RAS protein activator like 2
chr12_-_6716550 0.438 NM_001273
CHD4
chromodomain helicase DNA binding protein 4
chr10_+_21823573 0.438 NM_001195626
MLLT10
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10
chr8_-_48650683 0.436 CEBPD
CCAAT/enhancer binding protein (C/EBP), delta
chr11_-_65430427 0.435 NM_001145138
NM_001243984
NM_001243985
NM_021975
RELA



v-rel reticuloendotheliosis viral oncogene homolog A (avian)



chr3_+_53195214 0.435 NM_006254
NM_212539
PRKCD

protein kinase C, delta

chr13_-_73356070 0.434 NM_001128226
NM_014953
DIS3

DIS3 mitotic control homolog (S. cerevisiae)

chr8_-_22926406 0.433 TNFRSF10B
tumor necrosis factor receptor superfamily, member 10b
chr2_-_202508223 0.432 NM_001044385
TMEM237
transmembrane protein 237
chr16_+_31191470 0.429 FUS
fused in sarcoma
chr12_+_124069080 0.425 TMED2
transmembrane emp24 domain trafficking protein 2
chr3_-_189838673 0.421 LEPREL1
leprecan-like 1
chr9_-_131533850 0.421 ZER1
zer-1 homolog (C. elegans)
chr4_+_103422730 0.413 NFKB1
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
chr15_-_40212425 0.413 GPR176
G protein-coupled receptor 176
chr13_+_113656076 0.411 MCF2L
MCF.2 cell line derived transforming sequence-like
chr6_+_29910308 0.407 HLA-A
major histocompatibility complex, class I, A
chr4_-_2758018 0.406 NM_024309
TNIP2
TNFAIP3 interacting protein 2
chr11_+_82612736 0.405 NM_145018
C11orf82
chromosome 11 open reading frame 82
chr6_-_31324975 0.404 NM_005514
HLA-B
major histocompatibility complex, class I, B
chr13_+_49550949 0.404 FNDC3A
fibronectin type III domain containing 3A
chr16_+_31191462 0.402 FUS
fused in sarcoma
chr6_-_13711952 0.402 RANBP9
RAN binding protein 9
chr11_+_125774271 0.399 NM_013264
DDX25
DEAD (Asp-Glu-Ala-Asp) box polypeptide 25
chr16_-_31085503 0.397 NM_024706
ZNF668
zinc finger protein 668
chr14_-_100842637 0.396 WARS
tryptophanyl-tRNA synthetase
chr4_+_48343502 0.393 NM_020846
SLAIN2
SLAIN motif family, member 2
chr12_-_58165877 0.392 NM_005371
NM_023033
METTL1

methyltransferase like 1

chr14_-_51135041 0.386 SAV1
salvador homolog 1 (Drosophila)
chr10_-_119134737 0.386 NM_173791
PDZD8
PDZ domain containing 8
chr11_+_122526339 0.384 NM_032873
UBASH3B
ubiquitin associated and SH3 domain containing B
chr8_-_37756971 0.383 NM_001002814
NM_025151
RAB11FIP1

RAB11 family interacting protein 1 (class I)

chr17_-_45266627 0.381 CDC27
cell division cycle 27 homolog (S. cerevisiae)
chr13_-_73355969 0.380 DIS3
DIS3 mitotic control homolog (S. cerevisiae)
chr19_-_11039086 0.379 NM_024029
YIPF2
Yip1 domain family, member 2
chr14_+_32546445 0.377 NM_001030055
NM_001173
ARHGAP5

Rho GTPase activating protein 5

chr13_-_26795927 0.376 NM_183043
RNF6
ring finger protein (C3H2C3 type) 6
chr8_+_59465783 0.373 SDCBP
syndecan binding protein (syntenin)
chr15_+_72766689 0.373 ARIH1
ariadne homolog, ubiquitin-conjugating enzyme E2 binding protein, 1 (Drosophila)
chr12_+_58120029 0.370 LOC100130776
uncharacterized LOC100130776
chr3_+_112052020 0.369 CD200
CD200 molecule
chr21_-_40685545 0.367 BRWD1
bromodomain and WD repeat domain containing 1
chr16_+_19125243 0.363 NM_001034841
ITPRIPL2
inositol 1,4,5-trisphosphate receptor interacting protein-like 2
chr10_+_21823266 0.360 MLLT10
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10
chr3_-_150480963 0.355 NM_005067
SIAH2
seven in absentia homolog 2 (Drosophila)
chr1_-_235491494 0.353 NM_016374
NM_031371
ARID4B

AT rich interactive domain 4B (RBP1-like)

chr13_-_26795821 0.352 NM_183044
RNF6
ring finger protein (C3H2C3 type) 6
chr16_-_84651639 0.350 NM_021149
COTL1
coactosin-like 1 (Dictyostelium)
chr16_+_31044414 0.348 STX4
syntaxin 4
chr6_-_119670897 0.340 NM_005907
MAN1A1
mannosidase, alpha, class 1A, member 1
chr20_+_825284 0.339 NM_031424
FAM110A
family with sequence similarity 110, member A
chr16_+_87425998 0.336 MAP1LC3B
microtubule-associated protein 1 light chain 3 beta
chr6_-_75994496 0.335 TMEM30A
transmembrane protein 30A
chr21_+_30396911 0.334 NM_001001992
NM_001032410
NM_006447
USP16


ubiquitin specific peptidase 16


chr5_-_95297424 0.332 ELL2
elongation factor, RNA polymerase II, 2
chr17_-_38020421 0.331 NM_012481
NM_183228
NM_183229
NM_183230
NM_183231
NM_183232
IKZF3





IKAROS family zinc finger 3 (Aiolos)





chr5_-_115910406 0.330 NM_020796
SEMA6A
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A
chr12_-_6715524 0.330 CHD4
chromodomain helicase DNA binding protein 4
chr4_+_38869346 0.329 NM_138389
FAM114A1
family with sequence similarity 114, member A1
chr5_-_137090033 0.329 HNRNPA0
heterogeneous nuclear ribonucleoprotein A0
chr16_+_25703346 0.329 NM_006040
HS3ST4
heparan sulfate (glucosamine) 3-O-sulfotransferase 4
chr8_+_59465818 0.328 SDCBP
syndecan binding protein (syntenin)
chr7_+_6144589 0.326 USP42
ubiquitin specific peptidase 42
chr6_+_29910246 0.326 NM_001242758
NM_002116
HLA-A

major histocompatibility complex, class I, A

chr20_+_37590969 0.323 NM_001190809
NM_021931
DHX35

DEAH (Asp-Glu-Ala-His) box polypeptide 35

chr5_+_113698304 0.322 KCNN2
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2
chr19_+_57702833 0.320 NM_003417
ZNF264
zinc finger protein 264
chr4_+_48343338 0.320 SLAIN2
SLAIN motif family, member 2
chr13_-_20357125 0.314 NM_001042414
PSPC1
paraspeckle component 1
chrX_-_21676416 0.314 NM_153270
KLHL34
kelch-like 34 (Drosophila)
chr6_+_135502521 0.313 MYB
v-myb myeloblastosis viral oncogene homolog (avian)
chr6_+_108487214 0.313 NM_003269
NR2E1
nuclear receptor subfamily 2, group E, member 1
chr2_+_208394756 0.311 CREB1
cAMP responsive element binding protein 1
chr13_-_21635629 0.307 LATS2
LATS, large tumor suppressor, homolog 2 (Drosophila)
chr2_+_223725675 0.306 NM_004457
NM_203372
ACSL3

acyl-CoA synthetase long-chain family member 3

chr16_+_56965747 0.305 NM_001010989
NM_001010990
NM_014685
HERPUD1


homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1


chr3_-_189838907 0.304 NM_018192
LEPREL1
leprecan-like 1
chr1_-_8939150 0.304 NM_001428
ENO1
enolase 1, (alpha)
chr3_-_98620452 0.303 NM_080927
DCBLD2
discoidin, CUB and LCCL domain containing 2
chr14_+_50087400 0.301 NM_002408
MGAT2
mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase
chr13_-_20357043 0.300 PSPC1
paraspeckle component 1
chr22_-_30685485 0.298 NM_001037666
GATSL3
GATS protein-like 3
chr5_+_141348731 0.297 RNF14
ring finger protein 14
chr9_+_130186714 0.297 ZNF79
zinc finger protein 79
chr19_-_10491212 0.296 NM_003331
TYK2
tyrosine kinase 2
chr5_+_76114881 0.296 F2RL1
coagulation factor II (thrombin) receptor-like 1
chr18_+_9136742 0.295 NM_001083625
NM_015208
ANKRD12

ankyrin repeat domain 12

chr15_-_50978726 0.293 TRPM7
transient receptor potential cation channel, subfamily M, member 7
chr12_+_124069099 0.293 TMED2
transmembrane emp24 domain trafficking protein 2
chr6_-_75915566 0.292 NM_004370
NM_080645
COL12A1

collagen, type XII, alpha 1

chr1_+_156339002 0.290 NM_020407
RHBG
Rh family, B glycoprotein (gene/pseudogene)
chrX_+_40440261 0.289 ATP6AP2
ATPase, H+ transporting, lysosomal accessory protein 2
chr17_-_26972165 0.289 KIAA0100
KIAA0100
chr7_-_105925329 0.287 NAMPT
nicotinamide phosphoribosyltransferase
chr6_-_13711643 0.286 NM_005493
RANBP9
RAN binding protein 9
chr15_+_81293286 0.286 NM_022566
MESDC1
mesoderm development candidate 1

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.39 1.57e-09 GO:0044260 cellular macromolecule metabolic process
1.25 6.22e-06 GO:0044237 cellular metabolic process
1.29 1.59e-05 GO:0043170 macromolecule metabolic process
1.44 3.29e-05 GO:0044267 cellular protein metabolic process
1.12 9.33e-05 GO:0009987 cellular process
1.21 3.71e-04 GO:0044238 primary metabolic process
1.37 6.66e-04 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.49 9.40e-04 GO:0016070 RNA metabolic process
1.19 1.06e-03 GO:0008152 metabolic process
1.46 1.20e-03 GO:0006464 protein modification process
1.44 1.76e-03 GO:0043412 macromolecule modification
3.04 1.92e-03 GO:0006403 RNA localization
1.44 3.69e-03 GO:0010467 gene expression
1.52 8.27e-03 GO:0033036 macromolecule localization
3.01 1.11e-02 GO:0051028 mRNA transport
1.84 1.19e-02 GO:0016071 mRNA metabolic process
2.88 1.37e-02 GO:0050657 nucleic acid transport
2.88 1.37e-02 GO:0050658 RNA transport
2.88 1.37e-02 GO:0051236 establishment of RNA localization
1.63 1.74e-02 GO:0006351 transcription, DNA-dependent
1.35 3.68e-02 GO:0090304 nucleic acid metabolic process
1.28 3.74e-02 GO:0034641 cellular nitrogen compound metabolic process
15.47 3.96e-02 GO:0046796 viral genome transport in host cell
1.60 4.19e-02 GO:0015031 protein transport
1.29 4.30e-02 GO:0019538 protein metabolic process
1.59 4.53e-02 GO:0045184 establishment of protein localization

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.15 3.20e-11 GO:0005622 intracellular
1.16 4.35e-11 GO:0044424 intracellular part
1.30 6.35e-09 GO:0005634 nucleus
1.19 4.84e-08 GO:0043227 membrane-bounded organelle
1.19 5.75e-08 GO:0043231 intracellular membrane-bounded organelle
1.59 9.56e-08 GO:0031981 nuclear lumen
1.16 7.05e-07 GO:0043229 intracellular organelle
1.16 7.07e-07 GO:0043226 organelle
1.50 8.16e-07 GO:0044428 nuclear part
1.48 1.43e-06 GO:0070013 intracellular organelle lumen
1.18 3.12e-06 GO:0005737 cytoplasm
1.45 7.08e-06 GO:0043233 organelle lumen
1.44 1.56e-05 GO:0031974 membrane-enclosed lumen
1.22 1.63e-04 GO:0044446 intracellular organelle part
1.54 3.59e-04 GO:0005654 nucleoplasm
1.21 4.54e-04 GO:0044422 organelle part
1.61 9.01e-04 GO:0005794 Golgi apparatus
1.65 1.08e-02 GO:0015630 microtubule cytoskeleton
1.70 1.18e-02 GO:0044431 Golgi apparatus part
1.29 1.65e-02 GO:0043228 non-membrane-bounded organelle
1.29 1.65e-02 GO:0043232 intracellular non-membrane-bounded organelle
1.17 2.20e-02 GO:0044444 cytoplasmic part

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.23 1.00e-07 GO:0005515 protein binding
1.11 8.34e-06 GO:0005488 binding
1.28 3.03e-03 GO:0003676 nucleic acid binding
1.35 4.81e-03 GO:0000166 nucleotide binding
1.59 1.41e-02 GO:0003723 RNA binding