Motif ID: GCAGCAU

Z-value: 0.863


Mature miRNA associated with seed GCAGCAU:

NamemiRBase Accession
hsa-miR-103a MIMAT0000101
hsa-miR-107 MIMAT0000104



Activity profile for motif GCAGCAU.

activity profile for motif GCAGCAU


Sorted Z-values histogram for motif GCAGCAU

Sorted Z-values for motif GCAGCAU



Network of associatons between targets according to the STRING database.



First level regulatory network of GCAGCAU

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr11_+_19372270 1.963 NM_001111018
NAV2
neuron navigator 2
chr11_+_19734821 1.954 NM_001244963
NM_145117
NM_182964
NAV2


neuron navigator 2


chr8_+_106331146 1.283 NM_012082
ZFPM2
zinc finger protein, multitype 2
chr5_-_59189620 1.192 NM_001104631
PDE4D
phosphodiesterase 4D, cAMP-specific
chr22_+_41697452 1.122 NM_017590
ZC3H7B
zinc finger CCCH-type containing 7B
chr7_-_139477437 1.073 NM_001113239
NM_022740
HIPK2

homeodomain interacting protein kinase 2

chr5_-_59783885 1.063 NM_001165899
PDE4D
phosphodiesterase 4D, cAMP-specific
chr5_-_58571916 1.055 NM_001197220
PDE4D
phosphodiesterase 4D, cAMP-specific
chr5_-_58882274 1.037 NM_006203
PDE4D
phosphodiesterase 4D, cAMP-specific
chr5_-_58334936 1.036 NM_001197221
NM_001197222
PDE4D

phosphodiesterase 4D, cAMP-specific

chr5_-_58295758 1.014 NM_001197223
PDE4D
phosphodiesterase 4D, cAMP-specific
chr12_+_64238511 1.009 NM_020762
SRGAP1
SLIT-ROBO Rho GTPase activating protein 1
chr5_-_58652671 0.986 NM_001197219
PDE4D
phosphodiesterase 4D, cAMP-specific
chr5_-_126366439 0.967 NM_178450
MARCH3
membrane-associated ring finger (C3HC4) 3
chr5_-_59064437 0.965 NM_001197218
PDE4D
phosphodiesterase 4D, cAMP-specific
chr8_+_17396285 0.920 NM_001164771
NM_003046
SLC7A2

solute carrier family 7 (cationic amino acid transporter, y+ system), member 2

chr3_+_88188261 0.919 NM_018293
ZNF654
zinc finger protein 654
chr8_+_17354562 0.905 NM_001008539
SLC7A2
solute carrier family 7 (cationic amino acid transporter, y+ system), member 2
chr3_-_98620452 0.892 NM_080927
DCBLD2
discoidin, CUB and LCCL domain containing 2
chr20_-_3996035 0.870 NM_007219
NM_001134337
NM_001134338
RNF24


ring finger protein 24


chr1_+_90286469 0.845 NM_001134479
LRRC8D
leucine rich repeat containing 8 family, member D
chr22_-_42017032 0.843 NM_015704
PPPDE2
PPPDE peptidase domain containing 2
chr13_-_80915041 0.811 NM_005842
SPRY2
sprouty homolog 2 (Drosophila)
chr3_-_194188967 0.779 NM_024524
ATP13A3
ATPase type 13A3
chr10_-_62149487 0.759 NM_020987
ANK3
ankyrin 3, node of Ranvier (ankyrin G)
chr4_-_153273683 0.756 NM_018315
FBXW7
F-box and WD repeat domain containing 7
chr21_-_16437125 0.746 NM_003489
NRIP1
nuclear receptor interacting protein 1
chr2_+_210636700 0.725 NM_032504
NM_182587
UNC80

unc-80 homolog (C. elegans)

chr1_+_90287404 0.703 NM_018103
LRRC8D
leucine rich repeat containing 8 family, member D
chr12_+_26205490 0.691 NM_001164746
RASSF8
Ras association (RalGDS/AF-6) domain family (N-terminal) member 8
chr3_-_164914448 0.663 NM_014926
SLITRK3
SLIT and NTRK-like family, member 3
chr5_+_67586466 0.662 NM_181504
PIK3R1
phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
chr4_-_153456152 0.652 NM_033632
FBXW7
F-box and WD repeat domain containing 7
chr5_-_146833150 0.652 NM_001387
DPYSL3
dihydropyrimidinase-like 3
chr7_-_92463211 0.652 NM_001259
CDK6
cyclin-dependent kinase 6
chr7_-_92465929 0.651 NM_001145306
CDK6
cyclin-dependent kinase 6
chr10_+_98592658 0.634 NM_032440
LCOR
ligand dependent nuclear receptor corepressor
chr2_-_46384 0.632 NM_001077710
FAM110C
family with sequence similarity 110, member C
chr1_-_120612301 0.623 NM_001200001
NM_024408
NOTCH2

notch 2

chr5_+_34656367 0.622 NM_001145522
NM_015577
RAI14

retinoic acid induced 14

chr10_+_98592015 0.619 NM_001170765
NM_001170766
LCOR

ligand dependent nuclear receptor corepressor

chr10_-_62493282 0.618 NM_001204403
ANK3
ankyrin 3, node of Ranvier (ankyrin G)
chr5_+_34656595 0.605 NM_001145520
RAI14
retinoic acid induced 14
chr14_+_32546445 0.598 NM_001030055
NM_001173
ARHGAP5

Rho GTPase activating protein 5

chr5_+_34687663 0.596 NM_001145523
RAI14
retinoic acid induced 14
chr12_+_26126687 0.596 NM_001164747
RASSF8
Ras association (RalGDS/AF-6) domain family (N-terminal) member 8
chr10_-_61900659 0.595 NM_001149
ANK3
ankyrin 3, node of Ranvier (ankyrin G)
chr4_+_140222668 0.584 NM_057175
NAA15
N(alpha)-acetyltransferase 15, NatA auxiliary subunit
chr14_-_53258329 0.584 NM_198066
GNPNAT1
glucosamine-phosphate N-acetyltransferase 1
chr5_+_67584251 0.562 NM_181524
PIK3R1
phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
chr17_+_40834571 0.556 NM_003632
CNTNAP1
contactin associated protein 1
chr12_+_8185241 0.548 NM_018416
FOXJ2
forkhead box J2
chr14_+_33408458 0.541 NM_001164749
NM_001165893
NM_022123
NM_173159
NPAS3



neuronal PAS domain protein 3



chr8_-_74791098 0.535 NM_001001481
NM_018299
UBE2W

ubiquitin-conjugating enzyme E2W (putative)

chr5_+_67588395 0.529 NM_001242466
PIK3R1
phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
chr5_+_161494647 0.528 NM_000816
NM_198903
NM_198904
GABRG2


gamma-aminobutyric acid (GABA) A receptor, gamma 2


chr5_-_146889618 0.521 NM_001197294
DPYSL3
dihydropyrimidinase-like 3
chr8_+_125985538 0.509 NM_152412
ZNF572
zinc finger protein 572
chr10_-_62332666 0.509 NM_001204404
ANK3
ankyrin 3, node of Ranvier (ankyrin G)
chr5_+_34684611 0.506 NM_001145521
NM_001145525
RAI14

retinoic acid induced 14

chr3_-_189840225 0.504 NM_001134418
LEPREL1
leprecan-like 1
chr10_+_124134093 0.501 NM_001001974
PLEKHA1
pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1
chr5_+_67511578 0.501 NM_181523
PIK3R1
phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
chr10_-_14372807 0.497 NM_018027
FRMD4A
FERM domain containing 4A
chr2_+_201170603 0.496 NM_015535
SPATS2L
spermatogenesis associated, serine-rich 2-like
chr22_+_45560529 0.494 NM_153645
NUP50
nucleoporin 50kDa
chr8_+_31497267 0.494 NM_013962
NRG1
neuregulin 1
chr6_+_34204576 0.493 NM_002131
NM_145899
NM_145903
HMGA1


high mobility group AT-hook 1


chr17_-_56595192 0.492 NM_004687
MTMR4
myotubularin related protein 4
chr1_-_156785938 0.490 NM_001161443
SH2D2A
SH2 domain containing 2A
chr11_-_16424391 0.488 NM_001145819
NM_017508
SOX6

SRY (sex determining region Y)-box 6

chr6_-_119031230 0.486 NM_001178035
CEP85L
centrosomal protein 85kDa-like
chr14_-_95599794 0.479 NM_001195573
DICER1
dicer 1, ribonuclease type III
chr1_+_206680863 0.470 NM_182663
NM_182664
RASSF5

Ras association (RalGDS/AF-6) domain family member 5

chr7_-_139876718 0.468 NM_030647
JHDM1D
jumonji C domain containing histone demethylase 1 homolog D (S. cerevisiae)
chr1_-_52831817 0.463 NM_032449
CC2D1B
coiled-coil and C2 domain containing 1B
chr8_+_32504250 0.459 NM_013959
NRG1
neuregulin 1
chr10_+_101419169 0.456 NM_020354
ENTPD7
ectonucleoside triphosphate diphosphohydrolase 7
chr2_+_201170795 0.453 NM_001100422
NM_001100424
NM_001100423
SPATS2L


spermatogenesis associated, serine-rich 2-like


chr12_-_57030083 0.448 NM_013449
BAZ2A
bromodomain adjacent to zinc finger domain, 2A
chr15_+_84322809 0.445 NM_207517
ADAMTSL3
ADAMTS-like 3
chr6_+_34206567 0.445 NM_145905
HMGA1
high mobility group AT-hook 1
chr10_+_124145584 0.443 NM_001195608
PLEKHA1
pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1
chr6_+_127440047 0.441 NM_032784
RSPO3
R-spondin 3
chr17_+_27717942 0.437 NM_020791
NM_025142
TAOK1

TAO kinase 1

chr3_+_140770742 0.434 NM_080862
SPSB4
splA/ryanodine receptor domain and SOCS box containing 4
chr17_-_71228482 0.431 NM_001098832
NM_032837
FAM104A

family with sequence similarity 104, member A

chr1_+_206730456 0.431 NM_182665
RASSF5
Ras association (RalGDS/AF-6) domain family member 5
chr4_+_48343502 0.431 NM_020846
SLAIN2
SLAIN motif family, member 2
chr1_+_26737232 0.421 NM_024674
LIN28A
lin-28 homolog A (C. elegans)
chr16_+_50186809 0.421 NM_001040284
NM_001040285
PAPD5

PAP associated domain containing 5

chr10_+_124151818 0.418 NM_021622
PLEKHA1
pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1
chr22_+_45559725 0.416 NM_007172
NUP50
nucleoporin 50kDa
chr4_+_2061238 0.408 NM_178557
NAT8L
N-acetyltransferase 8-like (GCN5-related, putative)
chr6_+_34204647 0.406 NM_145901
NM_145902
HMGA1

high mobility group AT-hook 1

chr14_-_95623665 0.406 NM_177438
DICER1
dicer 1, ribonuclease type III
chr22_-_32146119 0.395 NM_173566
PRR14L
proline rich 14-like
chr16_-_48644087 0.393 NM_153029
N4BP1
NEDD4 binding protein 1
chr9_-_37576248 0.388 NM_012166
FBXO10
F-box protein 10
chr3_-_142682177 0.388 NM_198504
PAQR9
progestin and adipoQ receptor family member IX
chr10_+_92980322 0.387 NM_032373
PCGF5
polycomb group ring finger 5
chr1_+_26438267 0.382 NM_001243533
NM_152835
PDIK1L

PDLIM1 interacting kinase 1 like

chrX_+_68048792 0.379 NM_004429
EFNB1
ephrin-B1
chr17_-_4167028 0.378 NM_016376
NM_020740
ANKFY1

ankyrin repeat and FYVE domain containing 1

chr8_+_59465727 0.377 NM_001007067
NM_001007068
NM_001007069
NM_001007070
NM_005625
SDCBP




syndecan binding protein (syntenin)




chr14_-_65438794 0.370 NM_198686
RAB15
RAB15, member RAS onocogene family
chrX_+_30671456 0.368 NM_000167
NM_001128127
NM_001205019
NM_203391
GK



glycerol kinase



chr7_-_47621741 0.368 NM_022748
TNS3
tensin 3
chr14_-_27066959 0.368 NM_002515
NM_006489
NM_006491
NOVA1


neuro-oncological ventral antigen 1


chr3_-_122233781 0.360 NM_002264
KPNA1
karyopherin alpha 1 (importin alpha 5)
chr3_-_160283361 0.348 NM_002268
KPNA4
karyopherin alpha 4 (importin alpha 3)
chrX_+_49832214 0.348 NM_000084
CLCN5
chloride channel 5
chr4_-_153303663 0.347 NM_001013415
FBXW7
F-box and WD repeat domain containing 7
chrX_+_64708614 0.345 NM_001010888
ZC3H12B
zinc finger CCCH-type containing 12B
chr12_-_123834984 0.339 NM_001167856
NM_018183
SBNO1

strawberry notch homolog 1 (Drosophila)

chr2_+_26256728 0.337 NM_016131
RAB10
RAB10, member RAS oncogene family
chrX_-_19988381 0.334 NM_198279
CXorf23
chromosome X open reading frame 23
chr4_+_57774035 0.333 NM_005612
REST
RE1-silencing transcription factor
chr3_-_113415313 0.333 NM_001009899
KIAA2018
KIAA2018
chr9_-_127905715 0.331 NM_001144877
NM_173690
SCAI

suppressor of cancer cell invasion

chr1_+_100435539 0.331 NM_012243
SLC35A3
solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3
chr10_-_105614952 0.329 NM_014631
SH3PXD2A
SH3 and PX domains 2A
chr4_-_56412968 0.328 NM_004898
CLOCK
clock homolog (mouse)
chr11_-_119294242 0.321 NM_006288
THY1
Thy-1 cell surface antigen
chr1_-_156786500 0.320 NM_001161441
NM_001161442
NM_001161444
NM_003975
SH2D2A



SH2 domain containing 2A



chr10_-_94003002 0.318 NM_001178137
CPEB3
cytoplasmic polyadenylation element binding protein 3
chr1_-_65431826 0.316 NM_002227
JAK1
Janus kinase 1
chr5_-_115910406 0.315 NM_020796
SEMA6A
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A
chr14_+_70078309 0.315 NM_014734
KIAA0247
KIAA0247
chr20_-_31071187 0.315 NM_080616
C20orf112
chromosome 20 open reading frame 112
chr3_-_24536176 0.314 NM_000461
NM_001128176
NM_001128177
NM_001252634
THRB



thyroid hormone receptor, beta



chr15_+_89631380 0.313 NM_007011
NM_152924
ABHD2

abhydrolase domain containing 2

chr12_+_26111951 0.313 NM_001164748
NM_007211
RASSF8

Ras association (RalGDS/AF-6) domain family (N-terminal) member 8

chr2_+_110371887 0.312 NM_023016
ANKRD57
ankyrin repeat domain 57
chr1_-_202679415 0.310 NM_177402
SYT2
synaptotagmin II
chr4_+_57775064 0.310 NM_001193508
REST
RE1-silencing transcription factor
chr22_-_38668966 0.306 NM_001195072
NM_012264
TMEM184B

transmembrane protein 184B

chr2_-_29297126 0.306 NM_001029883
C2orf71
chromosome 2 open reading frame 71
chr22_-_38668669 0.306 NM_001195071
TMEM184B
transmembrane protein 184B
chr1_-_41131323 0.305 NM_014747
RIMS3
regulating synaptic membrane exocytosis 3
chr6_-_30181197 0.304 NM_001242783
NM_003449
TRIM26

tripartite motif containing 26

chr17_-_28257017 0.304 NM_033389
SSH2
slingshot homolog 2 (Drosophila)
chr3_-_189838907 0.303 NM_018192
LEPREL1
leprecan-like 1
chr6_+_158733691 0.299 NM_001007466
NM_020245
TULP4

tubby like protein 4

chr12_+_54378929 0.294 NM_017409
HOXC10
homeobox C10
chr3_+_133292404 0.292 NM_001134422
NM_017548
CDV3

CDV3 homolog (mouse)

chr1_-_151300132 0.291 NM_001198773
NM_001198775
NM_002651
PI4KB


phosphatidylinositol 4-kinase, catalytic, beta


chr5_+_82767492 0.290 NM_001126336
NM_001164097
NM_001164098
NM_004385
VCAN



versican



chr20_+_24449834 0.286 NM_024893
SYNDIG1
synapse differentiation inducing 1
chr1_+_162466963 0.286 NM_001184763
UHMK1
U2AF homology motif (UHM) kinase 1
chr8_-_12612968 0.280 NM_152271
LONRF1
LON peptidase N-terminal domain and ring finger 1
chr15_+_69706619 0.278 NM_004856
NM_138555
KIF23

kinesin family member 23

chr2_+_208576239 0.277 NM_001142300
NM_152523
CCNYL1

cyclin Y-like 1

chr3_-_167452593 0.276 NM_007217
NM_145860
NM_145859
PDCD10


programmed cell death 10


chr1_+_110577219 0.275 NM_033088
FAM40A
family with sequence similarity 40, member A
chr11_-_9025531 0.275 NM_020645
NRIP3
nuclear receptor interacting protein 3
chr1_-_117210301 0.273 NM_001007237
NM_001542
IGSF3

immunoglobulin superfamily, member 3

chr10_+_54074037 0.272 NM_012242
DKK1
dickkopf 1 homolog (Xenopus laevis)
chr18_-_65183922 0.272 NM_032160
DSEL
dermatan sulfate epimerase-like
chr1_-_202612580 0.271 NM_001136504
SYT2
synaptotagmin II
chr16_+_57406398 0.270 NM_002996
CX3CL1
chemokine (C-X3-C motif) ligand 1
chr14_-_61190458 0.269 NM_017420
SIX4
SIX homeobox 4
chr6_+_69344939 0.269 NM_001704
BAI3
brain-specific angiogenesis inhibitor 3
chr1_-_220101925 0.266 NM_018713
SLC30A10
solute carrier family 30, member 10
chr8_-_57123858 0.261 NM_001114634
NM_001114635
NM_002655
PLAG1


pleiomorphic adenoma gene 1


chr12_+_122242580 0.260 NM_015048
SETD1B
SET domain containing 1B
chr1_-_151300168 0.260 NM_001198774
PI4KB
phosphatidylinositol 4-kinase, catalytic, beta
chr3_+_119187782 0.259 NM_152305
POGLUT1
protein O-glucosyltransferase 1
chr1_-_155532322 0.258 NM_018489
ASH1L
ash1 (absent, small, or homeotic)-like (Drosophila)
chr22_-_41864656 0.258 NM_032758
PHF5A
PHD finger protein 5A
chr19_+_1941157 0.257 NM_001319
CSNK1G2
casein kinase 1, gamma 2
chr22_-_28197469 0.256 NM_002430
MN1
meningioma (disrupted in balanced translocation) 1
chr1_+_78245306 0.256 NM_198549
FAM73A
family with sequence similarity 73, member A
chr8_+_124780742 0.253 NM_144963
FAM91A1
family with sequence similarity 91, member A1
chr5_+_175875355 0.249 NM_014613
FAF2
Fas associated factor family member 2
chr1_-_42801529 0.249 NM_001198850
FOXJ3
forkhead box J3
chr2_-_39347562 0.248 NM_005633
SOS1
son of sevenless homolog 1 (Drosophila)
chr9_+_97136817 0.247 NM_032558
HIATL1
hippocampus abundant transcript-like 1
chr5_-_160279045 0.245 NM_025153
ATP10B
ATPase, class V, type 10B
chr6_-_118973019 0.244 NM_001042475
NM_206921
CEP85L

centrosomal protein 85kDa-like

chr17_-_39316982 0.244 NM_032524
KRTAP4-4
keratin associated protein 4-4
chr19_+_30302861 0.244 NM_001238
CCNE1
cyclin E1
chr2_-_219925237 0.242 NM_002181
IHH
Indian hedgehog
chr1_-_42800623 0.242 NM_001198851
FOXJ3
forkhead box J3
chr17_-_3794036 0.241 NM_172206
CAMKK1
calcium/calmodulin-dependent protein kinase kinase 1, alpha
chr1_+_162467594 0.241 NM_144624
NM_175866
UHMK1

U2AF homology motif (UHM) kinase 1

chr1_+_955468 0.240 NM_198576
AGRN
agrin
chr3_+_42642105 0.240 NM_005385
NKTR
natural killer-tumor recognition sequence
chr10_+_86088156 0.240 NM_018999
FAM190B
family with sequence similarity 190, member B
chr17_+_8339135 0.240 NM_001025579
NM_030808
NDEL1

nudE nuclear distribution gene E homolog (A. nidulans)-like 1

chr15_+_41952572 0.240 NM_001080541
NM_001164273
MGA

MAX gene associated

chrX_-_103087106 0.238 NM_016370
RAB9B
RAB9B, member RAS oncogene family
chr3_-_107809754 0.238 NM_001777
NM_198793
CD47

CD47 molecule

chr10_-_100995558 0.233 NM_001166244
NM_001166245
NM_001166246
NM_021828
HPSE2



heparanase 2



chr1_-_38325224 0.230 NM_005955
MTF1
metal-regulatory transcription factor 1
chr12_-_39836760 0.228 NM_001173463
NM_001173464
NM_001173465
NM_017641
KIF21A



kinesin family member 21A



chr2_+_154728424 0.228 NM_052917
GALNT13
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 13 (GalNAc-T13)
chr16_-_90039239 0.228 NM_145039
CENPBD1
CENPB DNA-binding domains containing 1
chr6_-_108145507 0.228 NM_198081
SCML4
sex comb on midleg-like 4 (Drosophila)
chr16_-_74700775 0.227 NM_018124
RFWD3
ring finger and WD repeat domain 3

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.96 1.78e-06 GO:0007399 nervous system development
1.63 8.60e-05 GO:0048519 negative regulation of biological process
1.67 9.85e-05 GO:0048523 negative regulation of cellular process
1.29 1.69e-04 GO:0050794 regulation of cellular process
1.45 3.55e-04 GO:0023052 signaling
1.52 6.72e-04 GO:0048731 system development
1.76 1.03e-03 GO:0009653 anatomical structure morphogenesis
1.63 1.08e-03 GO:0030154 cell differentiation
1.25 1.71e-03 GO:0050789 regulation of biological process
1.24 2.16e-03 GO:0065007 biological regulation
1.46 2.36e-03 GO:0048856 anatomical structure development
1.58 3.75e-03 GO:0048869 cellular developmental process
1.42 6.93e-03 GO:0007275 multicellular organismal development
1.61 7.95e-03 GO:0006464 protein modification process
1.38 9.30e-03 GO:0032502 developmental process
1.47 1.08e-02 GO:0048518 positive regulation of biological process
1.50 1.40e-02 GO:0048522 positive regulation of cellular process
2.06 1.57e-02 GO:0010628 positive regulation of gene expression
1.83 1.61e-02 GO:0007154 cell communication
1.75 2.76e-02 GO:0010604 positive regulation of macromolecule metabolic process
1.39 2.79e-02 GO:0016043 cellular component organization
1.54 3.56e-02 GO:0043412 macromolecule modification
6.44 4.40e-02 GO:0002064 epithelial cell development

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.12 8.51e-03 GO:0005622 intracellular
8.94 1.13e-02 GO:0044304 main axon
1.39 1.57e-02 GO:0043234 protein complex
1.12 2.04e-02 GO:0044424 intracellular part
22.34 4.54e-02 GO:0033268 node of Ranvier
1.53 4.70e-02 GO:0005856 cytoskeleton

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.28 1.14e-05 GO:0005515 protein binding
1.12 5.38e-03 GO:0005488 binding
2.25 6.87e-03 GO:0019904 protein domain specific binding
3.52 3.16e-02 GO:0017124 SH3 domain binding
5.30 4.28e-02 GO:0008013 beta-catenin binding