Motif ID: GUCAGUU

Z-value: 0.632


Mature miRNA associated with seed GUCAGUU:

NamemiRBase Accession
hsa-miR-223 MIMAT0000280



Activity profile for motif GUCAGUU.

activity profile for motif GUCAGUU


Sorted Z-values histogram for motif GUCAGUU

Sorted Z-values for motif GUCAGUU



Network of associatons between targets according to the STRING database.



First level regulatory network of GUCAGUU

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr1_+_61542928 1.316 NM_001145511
NFIA
nuclear factor I/A
chr1_+_61547625 1.249 NM_001134673
NM_005595
NFIA

nuclear factor I/A

chr1_-_92371558 1.166 NM_001195684
TGFBR3
transforming growth factor, beta receptor III
chr1_+_61547388 1.147 NM_001145512
NFIA
nuclear factor I/A
chr18_+_42260774 1.072 NM_015559
SETBP1
SET binding protein 1
chr1_-_92351613 1.044 NM_001195683
NM_003243
TGFBR3

transforming growth factor, beta receptor III

chr11_-_33913835 0.997 NM_005574
LMO2
LIM domain only 2 (rhombotin-like 1)
chr11_-_33891485 0.956 NM_001142315
LMO2
LIM domain only 2 (rhombotin-like 1)
chr11_-_33891361 0.940 NM_001142316
LMO2
LIM domain only 2 (rhombotin-like 1)
chr5_-_88179278 0.880 NM_001193350
NM_002397
MEF2C

myocyte enhancer factor 2C

chr5_-_88199868 0.840 NM_001131005
NM_001193347
MEF2C

myocyte enhancer factor 2C

chr13_-_77460432 0.834 NM_138444
KCTD12
potassium channel tetramerisation domain containing 12
chr20_-_39317875 0.831 NM_005461
MAFB
v-maf musculoaponeurotic fibrosarcoma oncogene homolog B (avian)
chr1_+_84630575 0.808 NM_001242860
NM_001242861
PRKACB

protein kinase, cAMP-dependent, catalytic, beta

chr1_+_84630014 0.756 NM_001242857
NM_001242858
NM_001242859
PRKACB


protein kinase, cAMP-dependent, catalytic, beta


chr1_+_84609941 0.750 NM_182948
PRKACB
protein kinase, cAMP-dependent, catalytic, beta
chr10_-_131762017 0.729 NM_001005463
EBF3
early B-cell factor 3
chr4_-_90758126 0.721 NM_001146054
NM_007308
NM_000345
SNCA


synuclein, alpha (non A4 component of amyloid precursor)


chr5_-_88119604 0.718 NM_001193348
NM_001193349
MEF2C

myocyte enhancer factor 2C

chr4_-_90759446 0.711 NM_001146055
SNCA
synuclein, alpha (non A4 component of amyloid precursor)
chr1_+_84647342 0.706 NM_001242862
PRKACB
protein kinase, cAMP-dependent, catalytic, beta
chrX_+_77166178 0.679 NM_000052
ATP7A
ATPase, Cu++ transporting, alpha polypeptide
chr17_-_8534008 0.661 NM_005964
MYH10
myosin, heavy chain 10, non-muscle
chr10_-_81205091 0.623 NM_153367
ZCCHC24
zinc finger, CCHC domain containing 24
chrX_+_135278912 0.609 NM_001159701
NM_001159699
FHL1

four and a half LIM domains 1

chr9_-_14398981 0.607 NM_001190738
NFIB
nuclear factor I/B
chrX_+_135230736 0.599 NM_001159700
FHL1
four and a half LIM domains 1
chr1_-_95007139 0.583 NM_001178096
NM_001993
F3

coagulation factor III (thromboplastin, tissue factor)

chr4_-_99579540 0.569 NM_005723
TSPAN5
tetraspanin 5
chr9_-_14314036 0.556 NM_001190737
NM_005596
NFIB

nuclear factor I/B

chr1_+_178694273 0.546 NM_152663
RALGPS2
Ral GEF with PH domain and SH3 binding motif 2
chr5_-_55290601 0.522 NM_001190981
NM_002184
NM_175767
IL6ST


interleukin 6 signal transducer (gp130, oncostatin M receptor)


chr2_+_20646831 0.521 NM_004040
RHOB
ras homolog gene family, member B
chr12_-_31743822 0.519 NM_144973
DENND5B
DENN/MADD domain containing 5B
chrX_+_135251795 0.515 NM_001167819
FHL1
four and a half LIM domains 1
chr10_-_97321094 0.481 NM_015385
NM_024991
SORBS1

sorbin and SH3 domain containing 1

chrX_+_135229536 0.479 NM_001159702
NM_001159703
NM_001449
FHL1


four and a half LIM domains 1


chrX_+_135251454 0.476 NM_001159704
FHL1
four and a half LIM domains 1
chr2_+_12856813 0.470 NM_021643
TRIB2
tribbles homolog 2 (Drosophila)
chr14_-_78083109 0.453 NM_004863
SPTLC2
serine palmitoyltransferase, long chain base subunit 2
chr2_+_46524448 0.452 NM_001430
EPAS1
endothelial PAS domain protein 1
chr12_+_79257772 0.441 NM_001135805
SYT1
synaptotagmin I
chr12_+_79439432 0.439 NM_001135806
SYT1
synaptotagmin I
chr10_-_97200895 0.437 NM_001034954
NM_001034955
NM_001034956
NM_001034957
NM_006434
SORBS1




sorbin and SH3 domain containing 1




chr12_+_79258448 0.425 NM_005639
SYT1
synaptotagmin I
chr8_+_97505876 0.425 NM_002998
SDC2
syndecan 2
chr7_+_89840999 0.418 NM_001244944
NM_001244945
NM_152999
NM_001040665
NM_001244946
STEAP2




STEAP family member 2, metalloreductase




chr18_+_20715726 0.416 NM_001100619
CABLES1
Cdk5 and Abl enzyme substrate 1
chr18_+_20735788 0.414 NM_138375
CABLES1
Cdk5 and Abl enzyme substrate 1
chr3_+_39851028 0.412 NM_015460
MYRIP
myosin VIIA and Rab interacting protein
chr12_+_56915587 0.406 NM_002898
RBMS2
RNA binding motif, single stranded interacting protein 2
chr21_-_27945267 0.356 NM_052954
CYYR1
cysteine/tyrosine-rich 1
chr12_-_96794207 0.354 NM_001170464
NM_002595
CDK17

cyclin-dependent kinase 17

chr10_-_116286661 0.351 NM_006720
ABLIM1
actin binding LIM protein 1
chr2_-_110371669 0.349 NM_144710
NM_178584
SEPT10

septin 10

chr8_-_28243941 0.349 NM_018660
ZNF395
zinc finger protein 395
chr2_+_45878912 0.341 NM_005400
PRKCE
protein kinase C, epsilon
chr9_-_14693459 0.333 NM_178566
ZDHHC21
zinc finger, DHHC-type containing 21
chr10_-_116418056 0.331 NM_002313
ABLIM1
actin binding LIM protein 1
chr4_+_174089889 0.327 NM_017423
GALNT7
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 7 (GalNAc-T7)
chr20_+_30598244 0.325 NM_080625
C20orf160
chromosome 20 open reading frame 160
chr10_-_116444374 0.316 NM_001003407
NM_001003408
ABLIM1

actin binding LIM protein 1

chr2_-_240322620 0.314 NM_006037
HDAC4
histone deacetylase 4
chr20_-_33999780 0.314 NM_001184977
NM_018244
NM_199487
UQCC


ubiquinol-cytochrome c reductase complex chaperone


chr11_-_17191287 0.310 NM_002645
PIK3C2A
phosphoinositide-3-kinase, class 2, alpha polypeptide
chr12_+_72233486 0.307 NM_001146213
NM_001146214
NM_022771
TBC1D15


TBC1 domain family, member 15


chr1_+_97187174 0.305 NM_021190
PTBP2
polypyrimidine tract binding protein 2
chr8_-_91657898 0.298 NM_001008495
NM_001146273
TMEM64

transmembrane protein 64

chr12_+_27397077 0.285 NM_015000
STK38L
serine/threonine kinase 38 like
chr3_+_151985828 0.282 NM_021038
NM_207292
MBNL1

muscleblind-like (Drosophila)

chr22_+_47022657 0.282 NM_015124
GRAMD4
GRAM domain containing 4
chr7_-_129592711 0.277 NM_001202498
UBE2H
ubiquitin-conjugating enzyme E2H
chr1_+_164528586 0.268 NM_001204961
NM_001204963
NM_002585
PBX1


pre-B-cell leukemia homeobox 1


chr1_-_77685076 0.267 NM_005482
PIGK
phosphatidylinositol glycan anchor biosynthesis, class K
chr1_-_46598250 0.266 NM_003629
NM_001114172
PIK3R3

phosphoinositide-3-kinase, regulatory subunit 3 (gamma)

chr1_+_90098643 0.263 NM_032270
LRRC8C
leucine rich repeat containing 8 family, member C
chr20_-_4990913 0.260 NM_203327
SLC23A2
solute carrier family 23 (nucleobase transporters), member 2
chr8_-_67579446 0.257 NM_025054
VCPIP1
valosin containing protein (p97)/p47 complex interacting protein 1
chr1_-_173962050 0.256 NM_172071
RC3H1
ring finger and CCCH-type domains 1
chrX_-_34675366 0.256 NM_031442
TMEM47
transmembrane protein 47
chr8_-_81787015 0.254 NM_001033723
ZNF704
zinc finger protein 704
chr3_+_152017193 0.253 NM_207293
NM_207294
NM_207295
NM_207296
NM_207297
MBNL1




muscleblind-like (Drosophila)




chr5_-_90679115 0.250 NM_020801
ARRDC3
arrestin domain containing 3
chr17_+_25621105 0.249 NM_015626
NM_134265
WSB1

WD repeat and SOCS box containing 1

chr11_+_3876919 0.248 NM_003156
STIM1
stromal interaction molecule 1
chr20_-_4982133 0.246 NM_005116
SLC23A2
solute carrier family 23 (nucleobase transporters), member 2
chr12_-_54653369 0.245 NM_001127321
CBX5
chromobox homolog 5
chr7_-_129592794 0.245 NM_003344
NM_182697
UBE2H

ubiquitin-conjugating enzyme E2H

chr16_+_14164879 0.243 NM_014048
MKL2
MKL/myocardin-like 2
chr5_-_112630557 0.240 NM_002387
MCC
mutated in colorectal cancers
chr5_-_112824526 0.236 NM_001085377
MCC
mutated in colorectal cancers
chr4_+_123747815 0.233 NM_002006
FGF2
fibroblast growth factor 2 (basic)
chr3_+_37903643 0.232 NM_001008392
NM_005808
CTDSPL

CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like

chr13_-_41240607 0.229 NM_002015
FOXO1
forkhead box O1
chr12_+_3186520 0.229 NM_001168320
NM_006675
TSPAN9

tetraspanin 9

chr11_+_86748870 0.223 NM_001168724
NM_022918
TMEM135

transmembrane protein 135

chr3_+_194406614 0.222 NM_153690
FAM43A
family with sequence similarity 43, member A
chr1_-_161279724 0.215 NM_000530
MPZ
myelin protein zero
chr9_-_13250313 0.210 NM_003829
MPDZ
multiple PDZ domain protein
chr11_+_74459900 0.210 NM_001098638
RNF169
ring finger protein 169
chr3_-_93692898 0.206 NM_000313
PROS1
protein S (alpha)
chr15_+_77223942 0.205 NM_002902
RCN2
reticulocalbin 2, EF-hand calcium binding domain
chr7_-_132261268 0.204 NM_001105543
NM_020911
PLXNA4

plexin A4

chr12_-_54653317 0.200 NM_001127322
CBX5
chromobox homolog 5
chr1_+_65210724 0.200 NM_018211
RAVER2
ribonucleoprotein, PTB-binding 2
chr9_+_91003238 0.200 NM_006717
SPIN1
spindlin 1
chr12_+_53774422 0.199 NM_003109
SP1
Sp1 transcription factor
chr8_-_89339716 0.194 NM_005941
MMP16
matrix metallopeptidase 16 (membrane-inserted)
chr12_+_1100352 0.193 NM_178039
NM_178040
ERC1

ELKS/RAB6-interacting/CAST family member 1

chr6_-_16761600 0.193 NM_000332
NM_001128164
ATXN1

ataxin 1

chr10_+_82168206 0.192 NM_001243780
NM_001243781
NM_032333
C10orf58


chromosome 10 open reading frame 58


chr3_-_185270258 0.190 NM_139248
LIPH
lipase, member H
chr2_-_191878924 0.190 NM_007315
NM_139266
STAT1

signal transducer and activator of transcription 1, 91kDa

chr7_-_123388711 0.190 NM_003941
WASL
Wiskott-Aldrich syndrome-like
chrX_-_134049248 0.190 NM_019556
MOSPD1
motile sperm domain containing 1
chr3_-_124774735 0.190 NM_020733
HEG1
HEG homolog 1 (zebrafish)
chr3_-_13461802 0.188 NM_024923
NUP210
nucleoporin 210kDa
chr1_+_33004771 0.183 NM_001040441
ZBTB8A
zinc finger and BTB domain containing 8A
chr16_-_15982446 0.183 NM_144600
FOPNL
FGFR1OP N-terminal like
chr3_+_52828783 0.181 NM_002217
ITIH3
inter-alpha-trypsin inhibitor heavy chain 3
chr6_+_74405505 0.180 NM_001159587
NM_001159588
NM_133493
CD109


CD109 molecule


chr14_-_20020271 0.179 NM_001145442
POTEG
POTEM
POTE ankyrin domain family, member G
POTE ankyrin domain family, member M
chr1_+_163041694 0.179 NM_001113380
RGS4
regulator of G-protein signaling 4
chr10_-_33224485 0.179 NM_033668
ITGB1
integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
chr3_-_149375584 0.179 NM_001168280
NM_015472
WWTR1

WW domain containing transcription regulator 1

chr2_+_203499819 0.179 NM_173511
FAM117B
family with sequence similarity 117, member B
chr3_-_149421059 0.178 NM_001168278
WWTR1
WW domain containing transcription regulator 1
chr12_+_53773924 0.176 NM_001251825
NM_138473
SP1

Sp1 transcription factor

chr1_+_247579457 0.174 NM_001079821
NM_001127461
NLRP3

NLR family, pyrin domain containing 3

chr17_+_73629513 0.174 NM_001162995
C17orf109
chromosome 17 open reading frame 109
chr1_-_225616556 0.173 NM_194442
LBR
lamin B receptor
chr14_+_38677186 0.173 NM_001049
SSTR1
somatostatin receptor 1
chr11_+_94822937 0.172 NM_015036
ENDOD1
endonuclease domain containing 1
chr10_-_65225605 0.169 NM_032776
JMJD1C
jumonji domain containing 1C
chr9_-_125693778 0.168 NM_020924
ZBTB26
zinc finger and BTB domain containing 26
chr12_-_118541655 0.168 NM_019086
VSIG10
V-set and immunoglobulin domain containing 10
chr22_-_39548448 0.168 NM_175709
CBX7
chromobox homolog 7
chr7_-_106301329 0.166 NM_175884
C7orf74
chromosome 7 open reading frame 74
chr2_+_237993954 0.165 NM_006710
NM_198189
COPS8

COP9 constitutive photomorphogenic homolog subunit 8 (Arabidopsis)

chr1_+_163038395 0.165 NM_001102445
RGS4
regulator of G-protein signaling 4
chr9_-_99801365 0.164 NM_001333
CTSL2
cathepsin L2
chr17_-_73975507 0.164 NM_001185039
NM_004035
NM_007292
ACOX1


acyl-CoA oxidase 1, palmitoyl


chr4_-_77134987 0.162 NM_001204255
NM_005506
SCARB2

scavenger receptor class B, member 2

chr5_+_96294154 0.161 NM_175920
LNPEP
leucyl/cystinyl aminopeptidase
chr2_+_42396392 0.159 NM_001145076
NM_019063
EML4

echinoderm microtubule associated protein like 4

chr13_-_99738639 0.158 NM_001130049
NM_015296
DOCK9

dedicator of cytokinesis 9

chr3_-_71774407 0.158 NM_001134651
EIF4E3
eukaryotic translation initiation factor 4E family member 3
chr10_-_33246786 0.158 NM_133376
ITGB1
integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
chr1_+_93913566 0.157 NM_001024948
NM_001164473
NM_017737
FNBP1L


formin binding protein 1-like


chr5_+_96271345 0.156 NM_005575
LNPEP
leucyl/cystinyl aminopeptidase
chr1_-_182361311 0.155 NM_001033044
NM_002065
GLUL

glutamate-ammonia ligase

chr3_-_149688638 0.155 NM_002628
NM_053024
PFN2

profilin 2

chr11_-_85376159 0.154 NM_001039618
CREBZF
CREB/ATF bZIP transcription factor
chr10_-_65028825 0.152 NM_004241
JMJD1C
jumonji domain containing 1C
chr10_-_33247178 0.152 NM_002211
ITGB1
integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
chr1_+_163038934 0.151 NM_001113381
RGS4
regulator of G-protein signaling 4
chr1_+_163038564 0.151 NM_005613
RGS4
regulator of G-protein signaling 4
chr17_-_39183453 0.149 NM_031957
KRTAP1-5
keratin associated protein 1-5
chr14_+_53196852 0.149 NM_001130701
NM_145251
STYX

serine/threonine/tyrosine interacting protein

chr11_-_10315680 0.149 NM_030962
SBF2
SET binding factor 2
chr13_-_74707913 0.145 NM_007249
KLF12
Kruppel-like factor 12
chr13_-_76055872 0.144 NM_014832
TBC1D4
TBC1 domain family, member 4
chr2_-_99224868 0.144 NM_001008215
COA5
cytochrome C oxidase assembly factor 5
chr2_-_264037 0.144 NM_001159597
NM_015677
SH3YL1

SH3 domain containing, Ysc84-like 1 (S. cerevisiae)

chr12_+_25348138 0.142 NM_001001660
LYRM5
LYR motif containing 5
chr5_+_86564727 0.141 NM_022650
RASA1
RAS p21 protein activator (GTPase activating protein) 1
chr1_+_84543629 0.141 NM_002731
NM_207578
PRKACB

protein kinase, cAMP-dependent, catalytic, beta

chr17_-_46178559 0.138 NM_006807
CBX1
chromobox homolog 1
chr3_+_182511284 0.137 NM_014616
ATP11B
ATPase, class VI, type 11B
chr15_-_34828112 0.137 NM_001023567
GOLGA8A
GOLGA8B
golgin A8 family, member A
golgin A8 family, member B
chr5_+_140220811 0.137 NM_018911
NM_031856
PCDHA8

protocadherin alpha 8

chr1_+_25870043 0.134 NM_015627
LDLRAP1
low density lipoprotein receptor adaptor protein 1
chr17_-_46178761 0.133 NM_001127228
CBX1
chromobox homolog 1
chr9_-_72287097 0.132 NM_001163
APBA1
amyloid beta (A4) precursor protein-binding, family A, member 1
chr4_+_153700932 0.131 NM_001025593
NM_001025595
NM_014447
ARFIP1


ADP-ribosylation factor interacting protein 1


chr6_-_79787939 0.131 NM_017934
PHIP
pleckstrin homology domain interacting protein
chr16_+_8768403 0.130 NM_020686
ABAT
4-aminobutyrate aminotransferase
chr13_-_110438896 0.130 NM_003749
IRS2
insulin receptor substrate 2
chr4_-_42658883 0.129 NM_001105529
NM_006095
ATP8A1

ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1

chr8_+_81398416 0.129 NM_001105539
NM_023929
ZBTB10

zinc finger and BTB domain containing 10

chr12_+_104324186 0.129 NM_003299
HSP90B1
heat shock protein 90kDa beta (Grp94), member 1
chr17_-_76921453 0.129 NM_003255
TIMP2
TIMP metallopeptidase inhibitor 2
chr12_+_13197284 0.128 NM_020853
KIAA1467
KIAA1467
chr15_+_62359175 0.128 NM_207322
C2CD4A
C2 calcium-dependent domain containing 4A
chr8_-_27630096 0.128 NM_018246
CCDC25
coiled-coil domain containing 25
chr15_-_49338496 0.128 NM_001193489
NM_014701
SECISBP2L

SECIS binding protein 2-like

chr16_+_8814567 0.128 NM_001127448
ABAT
4-aminobutyrate aminotransferase
chr10_+_94449678 0.127 NM_002729
HHEX
hematopoietically expressed homeobox
chr7_-_4901437 0.126 NM_020144
PAPOLB
poly(A) polymerase beta (testis specific)
chr17_-_35969401 0.126 NM_001163544
NM_001163545
NM_001163546
NM_001163547
NM_007247
NM_080550
NM_198882
SYNRG






synergin, gamma






chr8_-_6420454 0.125 NM_001118887
NM_001118888
NM_001147
ANGPT2


angiopoietin 2


chr2_+_109335906 0.125 NM_006267
RANBP2
RAN binding protein 2
chr12_+_50794591 0.125 NM_001170803
NM_001170804
NM_001170808
NM_052879
NM_199188
NM_199190
LARP4





La ribonucleoprotein domain family, member 4





chr22_+_45704821 0.123 NM_001104595
FAM118A
family with sequence similarity 118, member A
chr2_-_99347588 0.123 NM_012214
MGAT4A
mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A
chr3_+_172472246 0.123 NM_018098
ECT2
epithelial cell transforming sequence 2 oncogene
chr15_-_52861177 0.123 NM_006628
ARPP19
cAMP-regulated phosphoprotein, 19kDa
chr3_+_130279177 0.122 NM_001102608
COL6A6
collagen, type VI, alpha 6
chr22_+_45705766 0.122 NM_017911
FAM118A
family with sequence similarity 118, member A
chr1_+_180601121 0.121 NM_001135669
NM_004736
XPR1

xenotropic and polytropic retrovirus receptor 1


Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
5.59 4.81e-10 GO:0007156 homophilic cell adhesion
2.82 1.04e-03 GO:0016337 cell-cell adhesion

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.06 1.71e-02 GO:0044464 cell part
1.06 1.73e-02 GO:0005623 cell
3.03 2.57e-02 GO:0005769 early endosome
7.07 4.74e-02 GO:0030140 trans-Golgi network transport vesicle

Gene overrepresentation in function category:

enrichment   p-value GO term description
2.16 1.19e-04 GO:0005509 calcium ion binding
1.12 6.41e-03 GO:0005488 binding
1.32 1.35e-02 GO:0046872 metal ion binding
1.30 2.57e-02 GO:0043169 cation binding
1.30 2.95e-02 GO:0043167 ion binding
1.19 3.97e-02 GO:0005515 protein binding