Motif ID: HAND1,2.p2

Z-value: 1.101


Transcription factors associated with HAND1,2.p2:

Gene SymbolEntrez IDGene Name
HAND1 9421 heart and neural crest derivatives expressed 1
HAND2 9464 heart and neural crest derivatives expressed 2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.p-valuePlot
HAND2chr4_-_1744513560.481.6e-02Click!
HAND1chr5_-_153857820-0.001.0e+00Click!


Activity profile for motif HAND1,2.p2.

activity profile for motif HAND1,2.p2


Sorted Z-values histogram for motif HAND1,2.p2

Sorted Z-values for motif HAND1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of HAND1,2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr2_+_228678556 3.203 NM_001130046
NM_004591
CCL20

chemokine (C-C motif) ligand 20

chr19_-_17958773 3.106 JAK3
Janus kinase 3
chr1_-_120612019 3.047 NOTCH2
notch 2
chr5_-_150467220 3.028 NM_001252390
TNIP1
TNFAIP3 interacting protein 1
chr22_-_36556781 2.958 NM_145640
APOL3
apolipoprotein L, 3
chr5_-_150466696 2.710 NM_001252391
NM_001252392
TNIP1

TNFAIP3 interacting protein 1

chr9_+_72658496 2.365 NM_153267
MAMDC2
MAM domain containing 2
chr1_-_149908759 2.326 NM_001145862
MTMR11
myotubularin related protein 11
chr1_-_149908721 1.964 MTMR11
myotubularin related protein 11
chr6_-_30652434 1.789 PPP1R18
protein phosphatase 1, regulatory subunit 18
chr9_+_72658735 1.715 MAMDC2
MAM domain containing 2
chr21_+_27012045 1.581 JAM2
junctional adhesion molecule 2
chr1_-_156722023 1.500 NM_001126051
NM_001126050
HDGF

hepatoma-derived growth factor

chr2_-_113542970 1.483 NM_000575
IL1A
interleukin 1, alpha
chr17_+_77020278 1.360 C1QTNF1
C1q and tumor necrosis factor related protein 1
chr3_-_123411185 1.301 MYLK
myosin light chain kinase
chrX_+_1455508 1.290 NM_002183
IL3RA
interleukin 3 receptor, alpha (low affinity)
chrY_+_1405508 1.245 NM_002183
IL3RA
interleukin 3 receptor, alpha (low affinity)
chr17_+_32582295 1.145 NM_002982
CCL2
chemokine (C-C motif) ligand 2
chr12_+_27485767 1.101 NM_001248002
NM_001248003
NM_001248004
NM_001248005
NM_020183
ARNTL2




aryl hydrocarbon receptor nuclear translocator-like 2




chr11_+_118827007 1.028 NM_006760
UPK2
uroplakin 2
chr6_+_134210247 1.022 NM_198392
NM_003206
TCF21

transcription factor 21

chr6_+_26440699 1.016 NM_001242803
NM_006994
NM_197974
BTN3A3


butyrophilin, subfamily 3, member A3


chr19_+_17186569 1.014 NM_001130065
NM_004145
MYO9B

myosin IXB

chr2_-_27718098 0.996 NM_022823
FNDC4
fibronectin type III domain containing 4
chr12_+_54891539 0.969 NCKAP1L
NCK-associated protein 1-like
chr18_+_21572736 0.963 NM_153211
TTC39C
tetratricopeptide repeat domain 39C
chr2_-_27718059 0.916 FNDC4
fibronectin type III domain containing 4
chr11_-_9225780 0.912 DENND5A
DENN/MADD domain containing 5A
chr9_-_123688352 0.906 TRAF1
TNF receptor-associated factor 1
chrX_+_128913881 0.896 NM_018990
SASH3
SAM and SH3 domain containing 3
chrX_+_128913897 0.894 SASH3
SAM and SH3 domain containing 3
chr14_-_61748510 0.885 NM_001017970
TMEM30B
transmembrane protein 30B
chr20_+_816710 0.874 NM_207121
FAM110A
family with sequence similarity 110, member A
chr11_+_369723 0.868 NM_178537
B4GALNT4
beta-1,4-N-acetyl-galactosaminyl transferase 4
chr12_+_113416267 0.862 NM_001032731
NM_002535
NM_016817
OAS2


2'-5'-oligoadenylate synthetase 2, 69/71kDa


chr2_+_97202463 0.856 NM_212481
ARID5A
AT rich interactive domain 5A (MRF1-like)
chr5_+_113769226 0.849 NM_170775
KCNN2
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2
chr6_+_26402464 0.845 NM_001145008
NM_001145009
NM_007048
NM_194441
BTN3A1



butyrophilin, subfamily 3, member A1



chr22_+_37309618 0.838 NM_000395
CSF2RB
colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)
chr17_-_40337384 0.836 NM_001524
HCRT
hypocretin (orexin) neuropeptide precursor
chr10_-_90712510 0.831 NM_001613
ACTA2
actin, alpha 2, smooth muscle, aorta
chr16_-_28608367 0.817 NM_001054
SULT1A2
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 2
chrX_+_70364680 0.809 NM_001166660
NM_018977
NM_181303
NLGN3


neuroligin 3


chrX_+_70364707 0.793 NLGN3
neuroligin 3
chr17_-_40264687 0.784 NM_024119
DHX58
DEXH (Asp-Glu-X-His) box polypeptide 58
chr10_-_121296044 0.774 NM_002925
RGS10
regulator of G-protein signaling 10
chr2_-_69098502 0.762 NM_014482
BMP10
bone morphogenetic protein 10
chr7_+_143079925 0.752 ZYX
zyxin
chr19_-_51893791 0.751 NM_001193623
LOC147646
uncharacterized LOC147646
chr1_-_209825797 0.742 NM_000228
LAMB3
laminin, beta 3
chrX_+_70364728 0.739 NLGN3
neuroligin 3
chr2_+_75059781 0.733 NM_000189
HK2
hexokinase 2
chr1_+_159409511 0.730 NM_012351
OR10J1
olfactory receptor, family 10, subfamily J, member 1
chr16_+_78056411 0.715 NM_005752
CLEC3A
C-type lectin domain family 3, member A
chrX_+_50027539 0.710 NM_033031
NM_033670
CCNB3

cyclin B3

chr19_+_44080951 0.709 NM_001193621
LOC390940
uncharacterized protein ENSP00000244321
chr14_-_24777064 0.706


chr3_-_123339423 0.706 NM_053031
NM_053032
MYLK

myosin light chain kinase

chr4_-_38666429 0.682 FLJ13197
uncharacterized FLJ13197
chr10_+_82297657 0.678 NM_207372
SH2D4B
SH2 domain containing 4B
chr11_+_2323356 0.669 TSPAN32
tetraspanin 32
chr1_-_209825673 0.648 NM_001127641
LAMB3
laminin, beta 3
chr15_+_69606741 0.643 NM_001104554
PAQR5
progestin and adipoQ receptor family member V
chr20_+_9288446 0.642 NM_000933
PLCB4
phospholipase C, beta 4
chr16_-_69385656 0.640 NM_144676
TMED6
transmembrane emp24 protein transport domain containing 6
chr12_+_49716970 0.632 NM_001100620
NM_005480
TROAP

trophinin associated protein (tastin)

chr20_-_1306512 0.630 NM_001199784
SDCBP2
syndecan binding protein (syntenin) 2
chr15_-_90222572 0.626 NM_001145311
NM_002666
PLIN1

perilipin 1

chr5_-_172756505 0.623 NM_003714
STC2
stanniocalcin 2
chr11_-_113577023 0.614 NM_030770
TMPRSS5
transmembrane protease, serine 5
chr10_-_75401492 0.606 NM_021245
MYOZ1
myozenin 1
chr12_-_53730003 0.606 NM_001173467
SP7
Sp7 transcription factor
chr19_+_18045904 0.601 NM_138442
CCDC124
coiled-coil domain containing 124
chr12_-_49259549 0.600 NM_014470
RND1
Rho family GTPase 1
chr5_+_34656482 0.590 RAI14
retinoic acid induced 14
chr9_+_35829375 0.586 NM_001042590
TMEM8B
transmembrane protein 8B
chr7_-_2883649 0.585 NM_007353
GNA12
guanine nucleotide binding protein (G protein) alpha 12
chr11_-_89650877 0.585 NM_001206627
LOC399939
ring finger protein 18-like
chr6_+_80340971 0.582 NM_031469
SH3BGRL2
SH3 domain binding glutamic acid-rich protein like 2
chr15_+_63889551 0.560 NM_203373
FBXL22
F-box and leucine-rich repeat protein 22
chr16_+_29674564 0.560 SPN
sialophorin
chr5_-_41261539 0.554 NM_001115131
C6
complement component 6
chr5_-_59783885 0.552 NM_001165899
PDE4D
phosphodiesterase 4D, cAMP-specific
chr17_-_39324423 0.543 NM_033187
KRTAP4-3
keratin associated protein 4-3
chr6_+_36922208 0.542 NM_153370
PI16
peptidase inhibitor 16
chr3_+_133494275 0.542 TF
transferrin
chr5_+_167913445 0.540 NM_002887
RARS
arginyl-tRNA synthetase
chr19_+_3708358 0.538 TJP3
tight junction protein 3 (zona occludens 3)
chr2_+_32853086 0.537 NM_001193509
NM_017735
TTC27

tetratricopeptide repeat domain 27

chr12_-_9913415 0.530 NM_001781
CD69
CD69 molecule
chr11_+_2323236 0.525 NM_139022
TSPAN32
tetraspanin 32
chr16_+_21245015 0.525 NM_145865
ANKS4B
ankyrin repeat and sterile alpha motif domain containing 4B
chr19_+_49259343 0.519 NM_019113
FGF21
fibroblast growth factor 21
chr2_-_31637553 0.515 XDH
xanthine dehydrogenase
chr12_+_49688908 0.515 NM_006262
PRPH
peripherin
chrX_+_69672356 0.514 DLG3
discs, large homolog 3 (Drosophila)
chr11_+_89659929 0.511 NM_001206627
LOC399939
ring finger protein 18-like
chr7_+_99816870 0.506 NM_024070
PVRIG
poliovirus receptor related immunoglobulin domain containing
chr12_+_54891522 0.502 NCKAP1L
NCK-associated protein 1-like
chrX_+_49832214 0.501 NM_000084
CLCN5
chloride channel 5
chr10_+_124145584 0.500 NM_001195608
PLEKHA1
pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1
chr12_+_75874512 0.499 NM_006851
GLIPR1
GLI pathogenesis-related 1
chr17_-_39646115 0.494 NM_003771
KRT36
keratin 36
chr1_-_173174611 0.483 TNFSF4
tumor necrosis factor (ligand) superfamily, member 4
chr6_-_39282095 0.482 NM_031460
NM_001135111
KCNK17

potassium channel, subfamily K, member 17

chr6_+_11094265 0.479 NM_001135575
C6orf228
chromosome 6 open reading frame 228
chr1_-_26644755 0.478 NM_145345
UBXN11
UBX domain protein 11
chr3_-_123339178 0.477 MYLK
myosin light chain kinase
chr7_-_76038894 0.475 NM_080744
SRCRB4D
scavenger receptor cysteine rich domain containing, group B (4 domains)
chr22_+_31478845 0.475 NM_001207017
SMTN
smoothelin
chr3_+_148415657 0.474 NM_000685
NM_004835
NM_009585
NM_031850
AGTR1



angiotensin II receptor, type 1



chr1_-_54199876 0.474 NM_147193
GLIS1
GLIS family zinc finger 1
chr7_-_141957846 0.473 NM_001001317
PRSS58
protease, serine, 58
chr5_-_138862342 0.470 NM_198282
TMEM173
transmembrane protein 173
chr21_+_37507209 0.469 NM_001236
CBR3
carbonyl reductase 3
chr11_-_117800067 0.467 NM_001077263
NM_001206789
NM_001206790
NM_001244995
TMPRSS13



transmembrane protease, serine 13



chr7_-_75419063 0.461 NM_006072
CCL26
chemokine (C-C motif) ligand 26
chr4_-_40631846 0.459 NM_001098634
RBM47
RNA binding motif protein 47
chr1_+_202091971 0.458 NM_004767
GPR37L1
G protein-coupled receptor 37 like 1
chr12_+_26205490 0.457 NM_001164746
RASSF8
Ras association (RalGDS/AF-6) domain family (N-terminal) member 8
chr1_-_173446273 0.453 LOC100506023
uncharacterized LOC100506023
chr6_+_134210264 0.453 TCF21
transcription factor 21
chr19_-_42931500 0.452 NM_005357
LIPE
lipase, hormone-sensitive
chr11_-_64703334 0.449 NM_130769
GPHA2
glycoprotein hormone alpha 2
chr5_-_138862224 0.440 TMEM173
transmembrane protein 173
chr1_+_11249344 0.436 NM_021146
ANGPTL7
angiopoietin-like 7
chr3_-_195310985 0.433 NM_001647
APOD
apolipoprotein D
chr20_+_58296264 0.431 NM_183244
NM_183246
PHACTR3

phosphatase and actin regulator 3

chr4_-_40632639 0.430 RBM47
RNA binding motif protein 47
chr3_-_190167597 0.429 NM_207316
TMEM207
transmembrane protein 207
chr14_+_74083547 0.427 NM_001037162
ACOT6
acyl-CoA thioesterase 6
chr10_-_99531712 0.427 NM_003015
SFRP5
secreted frizzled-related protein 5
chr3_+_149192367 0.426 NM_004617
TM4SF4
transmembrane 4 L six family member 4
chr5_-_146460991 0.426 NM_181677
NM_181678
PPP2R2B

protein phosphatase 2, regulatory subunit B, beta

chr10_-_104211244 0.422 NM_024886
C10orf95
chromosome 10 open reading frame 95
chr2_-_128100673 0.420 NM_006609
MAP3K2
mitogen-activated protein kinase kinase kinase 2
chr16_+_57438678 0.420 NM_002987
CCL17
chemokine (C-C motif) ligand 17
chr10_+_71812356 0.420 NM_018649
H2AFY2
H2A histone family, member Y2
chr17_+_3118911 0.419 NM_014565
OR1A1
olfactory receptor, family 1, subfamily A, member 1
chr9_+_35829208 0.419 NM_016446
NM_001042589
TMEM8B

transmembrane protein 8B

chr12_-_91505541 0.416 NM_002345
LUM
lumican
chr12_+_41086189 0.415 NM_001843
NM_175038
CNTN1

contactin 1

chr3_-_195310770 0.415 APOD
apolipoprotein D
chr1_+_36636690 0.415 MAP7D1
MAP7 domain containing 1
chr17_+_73720775 0.411 NM_001005619
ITGB4
integrin, beta 4
chr2_+_102803432 0.410 NM_003854
IL1RL2
interleukin 1 receptor-like 2
chr6_-_114384008 0.409 NM_153612
HS3ST5
heparan sulfate (glucosamine) 3-O-sulfotransferase 5
chr11_-_57004674 0.409 NM_005161
APLNR
apelin receptor
chr6_-_161087406 0.407 NM_005577
LPA
lipoprotein, Lp(a)
chr11_-_64764388 0.406 NM_138456
BATF2
basic leucine zipper transcription factor, ATF-like 2
chr17_-_39306053 0.405 NM_033188
KRTAP4-5
keratin associated protein 4-5
chr1_+_32661018 0.403 TXLNA
taxilin alpha
chr2_-_100939194 0.403 NM_198461
LONRF2
LON peptidase N-terminal domain and ring finger 2
chrX_-_69479516 0.402 NM_002565
P2RY4
pyrimidinergic receptor P2Y, G-protein coupled, 4
chr7_-_20256942 0.401 NM_182762
MACC1
metastasis associated in colon cancer 1
chr2_-_85637486 0.400 NM_001747
CAPG
capping protein (actin filament), gelsolin-like
chr1_-_209824641 0.400 NM_001017402
LAMB3
laminin, beta 3
chr14_-_69259654 0.400 ZFP36L1
zinc finger protein 36, C3H type-like 1
chr20_+_123230 0.394 NM_030931
DEFB126
defensin, beta 126
chr5_+_34687663 0.393 NM_001145523
RAI14
retinoic acid induced 14
chr9_-_25678855 0.391 NM_001004125
TUSC1
tumor suppressor candidate 1
chr20_-_42355566 0.388 NM_001008901
NM_176791
GTSF1L

gametocyte specific factor 1-like

chr19_+_47840370 0.379 NM_018485
GPR77
G protein-coupled receptor 77
chr7_-_84751246 0.378 NM_152754
SEMA3D
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D
chr6_+_167525294 0.373 NM_004367
CCR6
chemokine (C-C motif) receptor 6
chr3_+_149192479 0.372 TM4SF4
transmembrane 4 L six family member 4
chr11_+_71903172 0.362 NM_016729
FOLR1
folate receptor 1 (adult)
chr4_+_103422479 0.362 NM_001165412
NM_003998
NFKB1

nuclear factor of kappa light polypeptide gene enhancer in B-cells 1

chr21_+_34602205 0.362 NM_000874
NM_207584
NM_207585
IFNAR2


interferon (alpha, beta and omega) receptor 2


chr17_+_16319087 0.361 TRPV2
transient receptor potential cation channel, subfamily V, member 2
chr18_+_43405544 0.360 NM_213602
SIGLEC15
sialic acid binding Ig-like lectin 15
chr16_-_4854748 0.360 GLYR1
glyoxylate reductase 1 homolog (Arabidopsis)
chr11_-_119999516 0.358 TRIM29
tripartite motif containing 29
chr8_-_125580745 0.358 MTSS1
metastasis suppressor 1
chr21_-_43771069 0.357 NM_005423
TFF2
trefoil factor 2
chr1_+_44444848 0.356 NM_003780
B4GALT2
UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 2
chr17_-_8770976 0.354 NM_001010855
PIK3R6
phosphoinositide-3-kinase, regulatory subunit 6
chr1_-_183274008 0.353 NM_170706
NMNAT2
nicotinamide nucleotide adenylyltransferase 2
chr19_+_55587220 0.352 NM_133180
EPS8L1
EPS8-like 1
chr5_-_160279045 0.351 NM_025153
ATP10B
ATPase, class V, type 10B
chr5_-_149792370 0.347 NM_001025158
NM_001025159
NM_004355
CD74


CD74 molecule, major histocompatibility complex, class II invariant chain


chr22_+_41957011 0.347 NM_014460
CSDC2
cold shock domain containing C2, RNA binding
chr11_-_117698727 0.346 NM_021603
FXYD2
FXYD domain containing ion transport regulator 2
chr4_-_95263986 0.345 NM_014485
HPGDS
hematopoietic prostaglandin D synthase
chr11_-_10673832 0.345 NM_001098579
MRVI1
murine retrovirus integration site 1 homolog
chrX_+_47050208 0.341 UBA1
ubiquitin-like modifier activating enzyme 1
chr11_+_60869929 0.340 NM_014207
CD5
CD5 molecule
chr9_-_72873739 0.339 LOC100507299
uncharacterized LOC100507299
chr14_+_70078313 0.339 KIAA0247
KIAA0247
chr5_+_149887673 0.338 NM_001543
NDST1
N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1
chr11_-_64527369 0.338 PYGM
phosphorylase, glycogen, muscle
chr17_+_18380097 0.337 NM_001040078
LGALS9B
LGALS9C
lectin, galactoside-binding, soluble, 9B
lectin, galactoside-binding, soluble, 9C
chr2_-_228497801 0.337 NM_001162483
NM_020161
C2orf83

chromosome 2 open reading frame 83

chr16_-_20338808 0.336 NM_001007240
NM_001007241
NM_001007242
NM_001502
GP2



glycoprotein 2 (zymogen granule membrane)



chr12_-_53600999 0.336 NM_000889
ITGB7
integrin, beta 7
chr4_+_47033294 0.336 NM_000812
GABRB1
gamma-aminobutyric acid (GABA) A receptor, beta 1
chr10_-_101380160 0.335 SLC25A28
solute carrier family 25, member 28
chr11_-_65667809 0.335 FOSL1
FOS-like antigen 1
chr3_-_71542628 0.335 FOXP1
forkhead box P1

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.67 6.05e-03 GO:0007154 cell communication
2.73 6.93e-03 GO:0003012 muscle system process
2.74 1.51e-02 GO:0006936 muscle contraction
2.21 3.96e-02 GO:0030029 actin filament-based process
9.03 4.54e-02 GO:0001516 prostaglandin biosynthetic process
9.03 4.54e-02 GO:0046457 prostanoid biosynthetic process

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.60 7.70e-08 GO:0005576 extracellular region
1.49 1.75e-05 GO:0044459 plasma membrane part
1.31 5.66e-05 GO:0071944 cell periphery
1.31 1.06e-04 GO:0005886 plasma membrane
1.67 1.38e-04 GO:0000267 cell fraction
1.62 1.89e-04 GO:0005887 integral to plasma membrane
1.59 4.55e-04 GO:0031226 intrinsic to plasma membrane
1.69 2.07e-03 GO:0005626 insoluble fraction
1.70 2.35e-03 GO:0005624 membrane fraction
1.63 2.03e-02 GO:0005615 extracellular space
1.15 2.87e-02 GO:0016020 membrane

Gene overrepresentation in function category:

enrichment   p-value GO term description
2.13 6.59e-03 GO:0003779 actin binding
1.59 8.40e-03 GO:0005102 receptor binding
2.63 2.39e-02 GO:0004252 serine-type endopeptidase activity
2.38 2.76e-02 GO:0005529 sugar binding