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Motif ID: HES1.p2

Z-value: 1.139

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Top targets:

Promoter	Score	Refseq	Gene Symbol	Gene Name
chr7_+_155089614	2.002		INSIG1	insulin induced gene 1
chr18_+_20715726	1.862	NM_001100619	CABLES1	Cdk5 and Abl enzyme substrate 1
chr2_-_86116016	1.291	NM_003896	ST3GAL5	ST3 beta-galactoside alpha-2,3-sialyltransferase 5
chr7_+_155089483	1.206	NM_005542 NM_198336 NM_198337	INSIG1	insulin induced gene 1
chr6_-_35109003	1.159	NM_001093728 NM_018679	TCP11	t-complex 11 homolog (mouse)
chr1_-_231175971	1.097	NM_198552	FAM89A	family with sequence similarity 89, member A
chr13_-_77460432	0.980	NM_138444	KCTD12	potassium channel tetramerisation domain containing 12
chr13_+_21277481	0.953	NM_138284	IL17D	interleukin 17D
chr8_+_38614756	0.831		TACC1	transforming, acidic coiled-coil containing protein 1
chr12_+_57482886	0.827		NAB2	NGFI-A binding protein 2 (EGR1 binding protein 2)
chr19_+_39833096	0.802		SAMD4B	sterile alpha motif domain containing 4B
chr15_+_67813466	0.757	NM_001143936	C15orf61	chromosome 15 open reading frame 61
chr13_+_42031679	0.755		C13orf15	chromosome 13 open reading frame 15
chr17_-_57184116	0.750		TRIM37	tripartite motif containing 37
chrX_+_150863729	0.743	NM_024082	PRRG3	proline rich Gla (G-carboxyglutamic acid) 3 (transmembrane)
chr17_+_35849950	0.736	NM_007026	DUSP14	dual specificity phosphatase 14
chr1_-_36184392	0.710		C1orf216	chromosome 1 open reading frame 216
chr18_-_500583	0.708	NM_130386	COLEC12	collectin sub-family member 12
chr12_+_8850479	0.705	NM_020734	RIMKLB	ribosomal modification protein rimK-like family member B
chr7_-_91763775	0.703		CYP51A1	cytochrome P450, family 51, subfamily A, polypeptide 1
chr1_-_33168356	0.698	NM_001161708 NM_030786	SYNC	syncoilin, intermediate filament protein
chr2_+_238536183	0.692	NM_001137550	LRRFIP1	leucine rich repeat (in FLII) interacting protein 1
chr13_+_42031690	0.690		C13orf15	chromosome 13 open reading frame 15
chr2_+_176994421	0.682	NM_001199747 NM_001199746 NM_019558	HOXD8	homeobox D8
chr17_-_57184114	0.679		TRIM37	tripartite motif containing 37
chr1_-_59042827	0.670		TACSTD2	tumor-associated calcium signal transducer 2
chr7_-_148581379	0.648		EZH2	enhancer of zeste homolog 2 (Drosophila)
chr21_-_40032563	0.647	NM_001243428	ERG	v-ets erythroblastosis virus E26 oncogene homolog (avian)
chr14_+_100438095	0.640		EVL	Enah/Vasp-like
chr1_+_61547625	0.627	NM_001134673 NM_005595	NFIA	nuclear factor I/A
chr13_+_42031525	0.620	NM_014059	C13orf15	chromosome 13 open reading frame 15
chr14_-_91526912	0.616	NM_004755 NM_182398	RPS6KA5	ribosomal protein S6 kinase, 90kDa, polypeptide 5
chr1_-_36184727	0.606	NM_152374	C1orf216	chromosome 1 open reading frame 216
chr8_-_93115453	0.599	NM_001198633 NM_175634	RUNX1T1	runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
chr20_+_11871364	0.589	NM_181443	BTBD3	BTB (POZ) domain containing 3
chr7_-_91763828	0.576	NM_000786	CYP51A1	cytochrome P450, family 51, subfamily A, polypeptide 1
chr5_+_95067511	0.571
chr1_+_236305831	0.564	NM_003272	GPR137B	G protein-coupled receptor 137B
chr2_-_152684689	0.563		ARL5A	ADP-ribosylation factor-like 5A
chr17_+_30813928	0.562	NM_003885	CDK5R1	cyclin-dependent kinase 5, regulatory subunit 1 (p35)
chr9_-_126030792	0.558	NM_018387	STRBP	spermatid perinuclear RNA binding protein
chr14_-_89883306	0.548	NM_005197	FOXN3	forkhead box N3
chr1_-_45672225	0.543	NM_020883	ZSWIM5	zinc finger, SWIM-type containing 5
chr1_+_25943958	0.537	NM_020379	MAN1C1	mannosidase, alpha, class 1C, member 1
chrX_-_50557019	0.531	NM_020717	SHROOM4	shroom family member 4
chr1_+_212458867	0.530	NM_006243	PPP2R5A	protein phosphatase 2, regulatory subunit B', alpha
chr20_-_50384899	0.527	NM_006045	ATP9A	ATPase, class II, type 9A
chr1_-_94374986	0.524	NM_002061	GCLM	glutamate-cysteine ligase, modifier subunit
chr6_+_160183510	0.521		ACAT2	acetyl-CoA acetyltransferase 2
chrX_-_9733916	0.515	NM_000273	GPR143	G protein-coupled receptor 143
chr12_-_124018428	0.512		RILPL1	Rab interacting lysosomal protein-like 1
chr20_-_50384861	0.502		ATP9A	ATPase, class II, type 9A
chr12_-_108954952	0.498		SART3	squamous cell carcinoma antigen recognized by T cells 3
chr17_+_35849997	0.493		DUSP14	dual specificity phosphatase 14
chr12_-_124018066	0.491	NM_178314	RILPL1	Rab interacting lysosomal protein-like 1
chr12_-_108954942	0.491		SART3	squamous cell carcinoma antigen recognized by T cells 3
chr5_-_31532164	0.487	NM_001100412 NM_013235	DROSHA	drosha, ribonuclease type III
chr1_+_178063237	0.478		RASAL2	RAS protein activator like 2
chr2_+_113403433	0.477	NM_005415	SLC20A1	solute carrier family 20 (phosphate transporter), member 1
chr14_+_53019865	0.476	NM_001099652	GPR137C	G protein-coupled receptor 137C
chr6_+_72892371	0.475		RIMS1	regulating synaptic membrane exocytosis 1
chr11_-_116968986	0.474	NM_025164	SIK3	SIK family kinase 3
chr1_+_92495484	0.471	NM_173567	EPHX4	epoxide hydrolase 4
chr9_+_133971862	0.465	NM_001185095 NM_001185096 NM_031426	AIF1L	allograft inflammatory factor 1-like
chr1_+_178062955	0.463		RASAL2	RAS protein activator like 2
chr8_+_42396716	0.460	NM_138436 NM_001135674 NM_001135675	C8orf40	chromosome 8 open reading frame 40
chr7_+_1097140	0.455	NM_138445	GPR146	G protein-coupled receptor 146
chr14_+_77228132	0.454	NM_014909	VASH1	vasohibin 1
chr15_+_67835002	0.453	NM_002757 NM_145160	MAP2K5	mitogen-activated protein kinase kinase 5
chr7_-_15726026	0.453		MEOX2	mesenchyme homeobox 2
chr1_+_178063302	0.453		RASAL2	RAS protein activator like 2
chrX_-_62570968	0.452	NM_001012968	SPIN4	spindlin family, member 4
chr16_-_88772732	0.452	NM_001171815	RNF166	ring finger protein 166
chr11_-_71159371	0.449		DHCR7	7-dehydrocholesterol reductase
chr7_+_89783789	0.449		STEAP1	six transmembrane epithelial antigen of the prostate 1
chr15_+_99645152	0.445	NM_015286 NM_145728	SYNM	synemin, intermediate filament protein
chr7_+_89783688	0.434	NM_012449	STEAP1	six transmembrane epithelial antigen of the prostate 1
chr19_+_18111923	0.433	NM_001025604	ARRDC2	arrestin domain containing 2
chrX_+_107069459	0.432		MID2	midline 2
chr1_+_43232928	0.431		C1orf50	chromosome 1 open reading frame 50
chr1_+_65991390	0.431		LEPR	leptin receptor
chr1_+_65991357	0.430	NM_001198687 NM_001198688 NM_001198689	LEPR	leptin receptor
chr9_-_13279562	0.426		MPDZ	multiple PDZ domain protein
chr13_-_29069215	0.425	NM_001159920 NM_001160030 NM_001160031 NM_002019	FLT1	fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)
chr7_+_106685007	0.424	NM_002736	PRKAR2B	protein kinase, cAMP-dependent, regulatory, type II, beta
chr15_-_75918028	0.421		SNUPN	snurportin 1
chr9_-_100459623	0.415	NM_000380	XPA	xeroderma pigmentosum, complementation group A
chr12_+_123319977	0.409	NM_003959	HIP1R	huntingtin interacting protein 1 related
chr12_+_13197284	0.406	NM_020853	KIAA1467	KIAA1467
chr16_-_1821503	0.406		NME3	non-metastatic cells 3, protein expressed in
chr6_+_52442104	0.404		FLJ37798	uncharacterized LOC401264
chr13_+_35516390	0.404	NM_015678	NBEA	neurobeachin
chr1_-_53793743	0.400	NM_001018054 NM_004631 NM_017522 NM_033300	LRP8	low density lipoprotein receptor-related protein 8, apolipoprotein e receptor
chr16_-_67217825	0.400	NM_001040715	KIAA0895L	KIAA0895-like
chr11_+_46299161	0.399	NM_052854	CREB3L1	cAMP responsive element binding protein 3-like 1
chr11_+_86748870	0.397	NM_001168724 NM_022918	TMEM135	transmembrane protein 135
chr11_-_119234628	0.397		USP2	ubiquitin specific peptidase 2
chr16_-_1821709	0.395	NM_002513	NME3	non-metastatic cells 3, protein expressed in
chr17_+_78075390	0.395		GAA	glucosidase, alpha; acid
chr17_+_4402128	0.395	NM_001124758	SPNS2	spinster homolog 2 (Drosophila)
chr9_-_100459556	0.395		XPA	xeroderma pigmentosum, complementation group A
chr5_+_149737296	0.395		TCOF1	Treacher Collins-Franceschetti syndrome 1
chr17_+_45727303	0.394		KPNB1	karyopherin (importin) beta 1
chr8_+_96037186	0.390	NM_152416	C8orf38	chromosome 8 open reading frame 38
chr6_+_137143748	0.388		PEX7	peroxisomal biogenesis factor 7
chr22_+_29279573	0.388	NM_001206998	ZNRF3	zinc and ring finger 3
chr20_+_42544781	0.386	NM_001098796 NM_032883	TOX2	TOX high mobility group box family member 2
chr4_+_108852671	0.383	NM_183075	CYP2U1	cytochrome P450, family 2, subfamily U, polypeptide 1
chr14_-_103995336	0.380
chr17_+_45726838	0.376		KPNB1	karyopherin (importin) beta 1
chr19_-_2308155	0.376	NM_001101391	LINGO3	leucine rich repeat and Ig domain containing 3
chr3_+_110790460	0.374	NM_001243286 NM_015480	PVRL3	poliovirus receptor-related 3
chr9_+_133971902	0.370		AIF1L	allograft inflammatory factor 1-like
chr7_-_148581377	0.369		EZH2	enhancer of zeste homolog 2 (Drosophila)
chr9_-_126030854	0.367	NM_001171137	STRBP	spermatid perinuclear RNA binding protein
chr13_-_21348081	0.367		N6AMT2	N-6 adenine-specific DNA methyltransferase 2 (putative)
chr10_-_105452878	0.366		SH3PXD2A	SH3 and PX domains 2A
chr17_+_75136985	0.365	NM_001039573 NM_001143998 NM_001143999 NM_003003	SEC14L1	SEC14-like 1 (S. cerevisiae)
chr6_+_86159738	0.363		NT5E	5'-nucleotidase, ecto (CD73)
chr17_+_78075299	0.363	NM_000152 NM_001079803 NM_001079804	GAA	glucosidase, alpha; acid
chr7_+_116312412	0.358	NM_000245 NM_001127500	MET	met proto-oncogene (hepatocyte growth factor receptor)
chr4_+_81952118	0.357	NM_001201	BMP3	bone morphogenetic protein 3
chr12_-_123920967	0.356		RILPL2	Rab interacting lysosomal protein-like 2
chr22_-_29075708	0.355	NM_001145418	TTC28	tetratricopeptide repeat domain 28
chr1_+_43232911	0.355	NM_024097	C1orf50	chromosome 1 open reading frame 50
chr12_+_68042493	0.354	NM_003583 NM_006482	DYRK2	dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2
chr7_-_91764036	0.354	NM_001146152	CYP51A1	cytochrome P450, family 51, subfamily A, polypeptide 1
chr2_+_10183630	0.353	NM_003597 NM_001177716	KLF11	Kruppel-like factor 11
chr1_+_78511588	0.351	NM_017655	GIPC2	GIPC PDZ domain containing family, member 2
chr6_+_57037333	0.350		BAG2	BCL2-associated athanogene 2
chr12_+_56661026	0.348	NM_001099337	COQ10A	coenzyme Q10 homolog A (S. cerevisiae)
chr8_-_48650683	0.347		CEBPD	CCAAT/enhancer binding protein (C/EBP), delta
chr19_+_1524072	0.345	NM_001243079	PLK5	polo-like kinase 5
chr7_-_148581297	0.344		EZH2	enhancer of zeste homolog 2 (Drosophila)
chr17_+_15848422	0.343		ADORA2B	adenosine A2b receptor
chr17_-_57184174	0.340	NM_001005207 NM_015294	TRIM37	tripartite motif containing 37
chr7_+_24612714	0.340	NM_016447	MPP6	membrane protein, palmitoylated 6 (MAGUK p55 subfamily member 6)
chr14_-_53019036	0.337	NM_001160047 NM_020784	TXNDC16	thioredoxin domain containing 16
chr7_+_94139331	0.337		CASD1	CAS1 domain containing 1
chr19_+_32896515	0.337	NM_001172774	DPY19L3	dpy-19-like 3 (C. elegans)
chr2_-_172750724	0.336	NM_003705	SLC25A12	solute carrier family 25 (mitochondrial carrier, Aralar), member 12
chr16_-_84178685	0.335	NM_001146051 NM_031463	HSDL1	hydroxysteroid dehydrogenase like 1
chr3_+_138327918	0.335	NM_018147	FAIM	Fas apoptotic inhibitory molecule
chr7_-_91763677	0.334		CYP51A1	cytochrome P450, family 51, subfamily A, polypeptide 1
chr3_-_187871816	0.334		LPP-AS2	LPP antisense RNA 2 (non-protein coding)
chr6_+_160183062	0.333		ACAT2	acetyl-CoA acetyltransferase 2
chr2_+_181845088	0.333	NM_182678 NM_006357	UBE2E3	ubiquitin-conjugating enzyme E2E 3
chrY_+_6114263	0.330	NM_022573	TSPY2 TSPY1	testis specific protein, Y-linked 2 testis specific protein, Y-linked 1
chr12_-_123921219	0.329	NM_145058	RILPL2	Rab interacting lysosomal protein-like 2
chr9_+_131451519	0.329		SET	SET nuclear oncogene
chr7_-_148581403	0.327	NM_001203247 NM_001203248 NM_004456 NM_152998	EZH2	enhancer of zeste homolog 2 (Drosophila)
chr1_+_63833324	0.324		ALG6	asparagine-linked glycosylation 6, alpha-1,3-glucosyltransferase homolog (S. cerevisiae)
chr2_-_62733475	0.322	NM_198276	TMEM17	transmembrane protein 17
chr1_+_210406194	0.322	NM_019605	SERTAD4	SERTA domain containing 4
chr1_-_45452266	0.321	NM_001166588 NM_020365	EIF2B3	eukaryotic translation initiation factor 2B, subunit 3 gamma, 58kDa
chr14_-_23821423	0.315	NM_020372	SLC22A17	solute carrier family 22, member 17
chr8_+_87354958	0.315	NM_007013	WWP1	WW domain containing E3 ubiquitin protein ligase 1
chr2_-_43453737	0.314	NM_006887	ZFP36L2	zinc finger protein 36, C3H type-like 2
chr1_-_55352818	0.313		DHCR24	24-dehydrocholesterol reductase
chr16_+_30406711	0.313	NM_152652	ZNF48	zinc finger protein 48
chr10_+_8096633	0.312	NM_001002295 NM_002051	GATA3	GATA binding protein 3
chr15_-_83680332	0.311		C15orf40	chromosome 15 open reading frame 40
chr12_+_3068442	0.311	NM_003213 NM_201441 NM_201443	TEAD4	TEA domain family member 4
chr12_+_3186520	0.309	NM_001168320 NM_006675	TSPAN9	tetraspanin 9
chr6_-_150346599	0.308	NM_130900	RAET1L	retinoic acid early transcript 1L
chrX_+_135067573	0.307	NM_001177651 NM_001042537 NM_006359	SLC9A6	solute carrier family 9 (sodium/hydrogen exchanger), member 6
chr16_+_2205809	0.307		TRAF7	TNF receptor-associated factor 7
chr14_-_30396811	0.307	NM_002742	PRKD1	protein kinase D1
chr9_+_134378335	0.306		POMT1	protein-O-mannosyltransferase 1
chr9_-_126692184	0.305	NM_020946 NM_024820	DENND1A	DENN/MADD domain containing 1A
chr1_+_227127937	0.304	NM_020247	ADCK3	aarF domain containing kinase 3
chr1_+_63833260	0.304	NM_013339	ALG6	asparagine-linked glycosylation 6, alpha-1,3-glucosyltransferase homolog (S. cerevisiae)
chr13_-_110438896	0.300	NM_003749	IRS2	insulin receptor substrate 2
chr2_+_10184371	0.300	NM_001177718	KLF11	Kruppel-like factor 11
chr15_-_83680369	0.299	NM_001160113 NM_001160114 NM_001160115 NM_001160116 NM_144597	C15orf40	chromosome 15 open reading frame 40
chr2_+_7057471	0.298	NM_014746	RNF144A	ring finger protein 144A
chr6_+_15245702	0.297		JARID2	jumonji, AT rich interactive domain 2
chr14_-_54421269	0.297	NM_130851	BMP4	bone morphogenetic protein 4
chr1_+_227127959	0.296		ADCK3	aarF domain containing kinase 3
chr9_+_134378353	0.296		POMT1	protein-O-mannosyltransferase 1
chr21_+_35445877	0.296		MRPS6	mitochondrial ribosomal protein S6
chr3_+_193853937	0.295		HES1	hairy and enhancer of split 1, (Drosophila)
chr21_+_35445808	0.295	NM_032476 NM_006933	MRPS6 SLC5A3	mitochondrial ribosomal protein S6 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
chr12_-_108954929	0.295		SART3	squamous cell carcinoma antigen recognized by T cells 3
chr14_+_77227783	0.295
chr10_-_94333847	0.295	NM_004969	IDE	insulin-degrading enzyme
chr6_+_160182988	0.294	NM_005891	ACAT2	acetyl-CoA acetyltransferase 2
chr2_+_181845803	0.293		UBE2E3	ubiquitin-conjugating enzyme E2E 3
chr7_+_64498643	0.293		CCT6P3	chaperonin containing TCP1, subunit 6 (zeta) pseudogene 3
chr2_+_29117503	0.293	NM_015131	WDR43	WD repeat domain 43
chr16_+_55542981	0.291		LPCAT2	lysophosphatidylcholine acyltransferase 2
chr19_+_35760002	0.291		USF2	upstream transcription factor 2, c-fos interacting
chr11_+_64001974	0.290	NM_001243733 NM_003377	VEGFB	vascular endothelial growth factor B
chr5_+_176237435	0.290	NM_133369	UNC5A	unc-5 homolog A (C. elegans)
chr5_+_139028483	0.289		CXXC5	CXXC finger protein 5
chr1_-_168105620	0.288	NM_153832	GPR161	G protein-coupled receptor 161
chrX_+_9754465	0.288	NM_001649	SHROOM2	shroom family member 2
chr17_-_882905	0.287	NM_022463	NXN	nucleoredoxin
chr1_-_45452215	0.287		EIF2B3	eukaryotic translation initiation factor 2B, subunit 3 gamma, 58kDa
chr1_+_227127999	0.286		ADCK3	aarF domain containing kinase 3

Gene overrepresentation in process category:

enrichment	p-value	GO term	description
1.24	9.17e-17	GO:0044237	cellular metabolic process
1.28	1.82e-13	GO:0044260	cellular macromolecule metabolic process
1.18	8.47e-12	GO:0008152	metabolic process
1.20	2.48e-11	GO:0044238	primary metabolic process
1.40	1.33e-08	GO:0006464	protein modification process
1.33	2.45e-08	GO:0044267	cellular protein metabolic process
1.38	4.65e-08	GO:0043412	macromolecule modification
1.20	3.30e-07	GO:0043170	macromolecule metabolic process
1.31	8.87e-07	GO:0044249	cellular biosynthetic process
1.30	1.04e-06	GO:0009058	biosynthetic process
1.09	8.19e-06	GO:0009987	cellular process
1.21	3.52e-04	GO:0006807	nitrogen compound metabolic process
1.21	1.12e-03	GO:0034641	cellular nitrogen compound metabolic process
1.23	1.24e-03	GO:0006139	nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.21	1.63e-03	GO:0019538	protein metabolic process
1.69	2.74e-02	GO:0032446	protein modification by small protein conjugation
1.26	4.20e-02	GO:0034645	cellular macromolecule biosynthetic process

Gene overrepresentation in compartment category:

enrichment	p-value	GO term	description
1.19	6.32e-21	GO:0043231	intracellular membrane-bounded organelle
1.19	7.41e-21	GO:0043227	membrane-bounded organelle
1.13	1.68e-20	GO:0044424	intracellular part
1.13	2.07e-20	GO:0005622	intracellular
1.15	2.21e-17	GO:0043226	organelle
1.15	2.83e-17	GO:0043229	intracellular organelle
1.21	2.14e-12	GO:0044444	cytoplasmic part
1.15	6.12e-12	GO:0005737	cytoplasm
1.19	1.47e-08	GO:0005634	nucleus
1.19	1.73e-08	GO:0044446	intracellular organelle part
1.17	1.81e-07	GO:0044422	organelle part
1.29	1.46e-05	GO:0031090	organelle membrane
1.32	5.53e-04	GO:0005739	mitochondrion
1.22	2.04e-03	GO:0031974	membrane-enclosed lumen
1.22	2.87e-03	GO:0070013	intracellular organelle lumen
1.22	6.46e-03	GO:0044428	nuclear part
1.21	6.60e-03	GO:0043233	organelle lumen
1.58	1.11e-02	GO:0019866	organelle inner membrane
1.21	1.80e-02	GO:0005829	cytosol
1.03	4.31e-02	GO:0044464	cell part
1.03	4.47e-02	GO:0005623	cell

Gene overrepresentation in function category:

enrichment	p-value	GO term	description
1.08	6.45e-08	GO:0005488	binding
1.36	3.84e-07	GO:0016740	transferase activity
1.14	1.48e-06	GO:0005515	protein binding
1.17	5.20e-06	GO:0003824	catalytic activity
1.25	2.17e-04	GO:0000166	nucleotide binding
1.39	1.21e-03	GO:0016772	transferase activity, transferring phosphorus-containing groups
1.41	2.91e-03	GO:0016301	kinase activity
1.55	2.98e-03	GO:0019904	protein domain specific binding
1.42	4.16e-03	GO:0016773	phosphotransferase activity, alcohol group as acceptor
1.45	6.57e-03	GO:0004672	protein kinase activity
1.27	8.45e-03	GO:0030554	adenyl nucleotide binding
1.17	1.79e-02	GO:0003676	nucleic acid binding
1.23	1.95e-02	GO:0017076	purine nucleotide binding
1.26	1.96e-02	GO:0032559	adenyl ribonucleotide binding
1.22	3.76e-02	GO:0032553	ribonucleotide binding
1.22	3.76e-02	GO:0032555	purine ribonucleotide binding
1.25	3.96e-02	GO:0005524	ATP binding
1.34	4.67e-02	GO:0003723	RNA binding