Motif ID: HIC1.p2

Z-value: 2.566


Transcription factors associated with HIC1.p2:

Gene SymbolEntrez IDGene Name
HIC1 3090 hypermethylated in cancer 1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.p-valuePlot
HIC1chr17_+_1958354,
chr17_+_1959512
-0.281.7e-01Click!


Activity profile for motif HIC1.p2.

activity profile for motif HIC1.p2


Sorted Z-values histogram for motif HIC1.p2

Sorted Z-values for motif HIC1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of HIC1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr11_-_33891485 9.766 NM_001142315
LMO2
LIM domain only 2 (rhombotin-like 1)
chr11_-_33891258 9.289 LMO2
LIM domain only 2 (rhombotin-like 1)
chr1_+_61547625 8.852 NM_001134673
NM_005595
NFIA

nuclear factor I/A

chr1_-_92351613 8.576 NM_001195683
NM_003243
TGFBR3

transforming growth factor, beta receptor III

chr2_+_7057471 7.971 NM_014746
RNF144A
ring finger protein 144A
chr20_-_62462568 7.937 ZBTB46
zinc finger and BTB domain containing 46
chr11_-_33891361 7.900 NM_001142316
LMO2
LIM domain only 2 (rhombotin-like 1)
chr1_-_92351476 7.809 TGFBR3
transforming growth factor, beta receptor III
chr11_-_33890931 7.705 LMO2
LIM domain only 2 (rhombotin-like 1)
chr2_-_99347430 6.555 MGAT4A
mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A
chr20_-_62680880 6.316 NM_018419
SOX18
SRY (sex determining region Y)-box 18
chr14_-_105635114 5.733 NM_002226
NM_145159
JAG2

jagged 2

chr9_-_111775721 5.639 NM_003798
CTNNAL1
catenin (cadherin-associated protein), alpha-like 1
chr7_-_132261268 5.570 NM_001105543
NM_020911
PLXNA4

plexin A4

chr7_-_11871735 5.570 NM_015204
THSD7A
thrombospondin, type I, domain containing 7A
chr14_-_105634708 5.363 JAG2
jagged 2
chr11_+_94822937 5.314 NM_015036
ENDOD1
endonuclease domain containing 1
chr8_+_27491384 5.094 SCARA3
scavenger receptor class A, member 3
chr20_-_23030141 5.034 NM_000361
THBD
thrombomodulin
chr8_-_48650683 4.986 CEBPD
CCAAT/enhancer binding protein (C/EBP), delta
chr13_-_72440143 4.960 DACH1
dachshund homolog 1 (Drosophila)
chr10_-_81205091 4.886 NM_153367
ZCCHC24
zinc finger, CCHC domain containing 24
chr3_+_20081853 4.856 KAT2B
K(lysine) acetyltransferase 2B
chr12_+_3186520 4.716 NM_001168320
NM_006675
TSPAN9

tetraspanin 9

chr22_-_19929447 4.676 TXNRD2
thioredoxin reductase 2
chr18_+_59992519 4.654 NM_003839
TNFRSF11A
tumor necrosis factor receptor superfamily, member 11a, NFKB activator
chr3_+_39851028 4.635 NM_015460
MYRIP
myosin VIIA and Rab interacting protein
chr9_+_79074067 4.563 NM_001097633
NM_001490
GCNT1

glucosaminyl (N-acetyl) transferase 1, core 2

chr9_+_139606916 4.511 NM_152421
FAM69B
family with sequence similarity 69, member B
chr11_+_101980736 4.480 NM_001130145
NM_001195044
NM_006106
YAP1


Yes-associated protein 1


chr3_+_32148136 4.471 GPD1L
glycerol-3-phosphate dehydrogenase 1-like
chr9_+_139972195 4.453 UAP1L1
UDP-N-acteylglucosamine pyrophosphorylase 1-like 1
chr3_+_32148000 4.386 NM_015141
GPD1L
glycerol-3-phosphate dehydrogenase 1-like
chr2_+_12856813 4.354 NM_021643
TRIB2
tribbles homolog 2 (Drosophila)
chr4_+_41362750 4.223 NM_001112717
NM_001112718
NM_014988
LIMCH1


LIM and calponin homology domains 1


chr1_-_236228374 4.206 NID1
nidogen 1
chr8_+_27491460 4.169 NM_016240
NM_182826
SCARA3

scavenger receptor class A, member 3

chr19_+_39897457 4.018 NM_003407
ZFP36
zinc finger protein 36, C3H type, homolog (mouse)
chr1_+_33207343 4.002 NM_020888
KIAA1522
KIAA1522
chr16_+_81478774 4.001 NM_198390
CMIP
c-Maf inducing protein
chr4_+_156588811 3.993 NM_001130684
GUCY1A3
guanylate cyclase 1, soluble, alpha 3
chr7_+_155089614 3.990 INSIG1
insulin induced gene 1
chr14_+_24867926 3.974 NM_025081
NYNRIN
NYN domain and retroviral integrase containing
chr3_+_49027281 3.939 NM_177938
NM_177939
P4HTM

prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)

chr12_-_96184510 3.914 NM_021229
NTN4
netrin 4
chr6_-_84419018 3.909 SNAP91
synaptosomal-associated protein, 91kDa homolog (mouse)
chr2_-_99347588 3.742 NM_012214
MGAT4A
mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A
chr3_+_37903643 3.727 NM_001008392
NM_005808
CTDSPL

CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like

chr3_+_49027770 3.680 P4HTM
prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
chr12_-_96184346 3.674 NTN4
netrin 4
chrX_+_9983793 3.573 NM_015691
WWC3
WWC family member 3
chr9_+_139971938 3.570 NM_207309
UAP1L1
UDP-N-acteylglucosamine pyrophosphorylase 1-like 1
chr17_+_15848230 3.539 NM_000676
ADORA2B
adenosine A2b receptor
chr12_+_20522178 3.514 NM_000921
PDE3A
phosphodiesterase 3A, cGMP-inhibited
chr16_+_55543044 3.454 LPCAT2
lysophosphatidylcholine acyltransferase 2
chr15_-_23378217 3.417 HERC2P2
hect domain and RLD 2 pseudogene 2
chr1_-_236228382 3.337 NID1
nidogen 1
chr19_-_41859519 3.278 TGFB1
transforming growth factor, beta 1
chrX_+_135229536 3.261 NM_001159702
NM_001159703
NM_001449
FHL1


four and a half LIM domains 1


chr7_+_155089483 3.238 NM_005542
NM_198336
NM_198337
INSIG1


insulin induced gene 1


chr16_+_81812925 3.214 PLCG2
phospholipase C, gamma 2 (phosphatidylinositol-specific)
chr15_-_69113213 3.189 ANP32A
acidic (leucine-rich) nuclear phosphoprotein 32 family, member A
chr4_+_156587861 3.187 NM_000856
NM_001130682
NM_001130686
NM_001130687
NM_001130683
NM_001130685
GUCY1A3





guanylate cyclase 1, soluble, alpha 3





chr16_+_81812899 3.183 PLCG2
phospholipase C, gamma 2 (phosphatidylinositol-specific)
chr10_+_102106958 3.158 SCD
stearoyl-CoA desaturase (delta-9-desaturase)
chr16_-_4166021 3.130 ADCY9
adenylate cyclase 9
chr8_+_98881277 3.103 NM_002380
NM_030583
MATN2

matrilin 2

chr18_+_20715726 3.054 NM_001100619
CABLES1
Cdk5 and Abl enzyme substrate 1
chr1_-_55352893 3.017 DHCR24
24-dehydrocholesterol reductase
chr8_-_48650703 3.017 NM_005195
CEBPD
CCAAT/enhancer binding protein (C/EBP), delta
chr10_+_112257624 3.007 NM_004419
DUSP5
dual specificity phosphatase 5
chr7_-_86688944 2.982 NM_001142749
KIAA1324L
KIAA1324-like
chr8_-_4852262 2.926 NM_033225
CSMD1
CUB and Sushi multiple domains 1
chr1_+_25943958 2.913 NM_020379
MAN1C1
mannosidase, alpha, class 1C, member 1
chr20_+_42543417 2.883 NM_001098797
TOX2
TOX high mobility group box family member 2
chr1_+_210406194 2.878 NM_019605
SERTAD4
SERTA domain containing 4
chr19_-_54693453 2.863 MBOAT7
membrane bound O-acyltransferase domain containing 7
chr21_+_46494433 2.857 NM_001112
NM_001160230
NM_015833
NM_015834
ADARB1



adenosine deaminase, RNA-specific, B1



chr5_+_139028483 2.854 CXXC5
CXXC finger protein 5
chr9_-_13279562 2.844 MPDZ
multiple PDZ domain protein
chr13_+_27131799 2.836 NM_006646
WASF3
WAS protein family, member 3
chr12_+_53440809 2.806 NM_198316
TENC1
tensin like C1 domain containing phosphatase (tensin 2)
chr1_-_55352818 2.792 DHCR24
24-dehydrocholesterol reductase
chr21_+_18885104 2.757 NM_001207063
NM_001207064
NM_001207065
NM_001207066
NM_001338
CXADR




coxsackie virus and adenovirus receptor




chr11_-_47207938 2.756 NM_001184974
NM_016223
PACSIN3

protein kinase C and casein kinase substrate in neurons 3

chr14_+_61788398 2.753 NM_006255
PRKCH
protein kinase C, eta
chr6_-_84419108 2.729 NM_001242793
NM_001242794
NM_014841
SNAP91


synaptosomal-associated protein, 91kDa homolog (mouse)


chr12_-_29936685 2.704 NM_001193451
TMTC1
transmembrane and tetratricopeptide repeat containing 1
chr20_-_47444404 2.704 NM_020820
PREX1
phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1
chr1_-_9970265 2.695 NM_001012329
NM_020248
CTNNBIP1

catenin, beta interacting protein 1

chr19_-_3700466 2.674 NM_001195733
NM_012398
PIP5K1C

phosphatidylinositol-4-phosphate 5-kinase, type I, gamma

chr19_-_41859830 2.631 NM_000660
TGFB1
transforming growth factor, beta 1
chr19_-_3700387 2.629 PIP5K1C
phosphatidylinositol-4-phosphate 5-kinase, type I, gamma
chr9_+_127020251 2.619 NEK6
NIMA (never in mitosis gene a)-related kinase 6
chr5_+_121647385 2.604 SNCAIP
synuclein, alpha interacting protein
chr6_-_84418705 2.579 NM_001242792
SNAP91
synaptosomal-associated protein, 91kDa homolog (mouse)
chr10_+_30723050 2.576 MAP3K8
mitogen-activated protein kinase kinase kinase 8
chr13_-_49107250 2.571 NM_001268
RCBTB2
regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
chr7_+_106685007 2.542 NM_002736
PRKAR2B
protein kinase, cAMP-dependent, regulatory, type II, beta
chr13_+_21277481 2.539 NM_138284
IL17D
interleukin 17D
chr4_-_114682836 2.531 NM_001221
NM_172114
NM_172115
NM_172127
NM_172128
NM_172129
CAMK2D





calcium/calmodulin-dependent protein kinase II delta





chr14_+_100438095 2.515 EVL
Enah/Vasp-like
chr10_+_102107001 2.502 SCD
stearoyl-CoA desaturase (delta-9-desaturase)
chr5_+_121647773 2.487 NM_001242935
NM_005460
SNCAIP

synuclein, alpha interacting protein

chr17_+_15848422 2.483 ADORA2B
adenosine A2b receptor
chr11_-_2162340 2.463 NM_001127598
IGF2
insulin-like growth factor 2 (somatomedin A)
chr2_-_190445612 2.462 SLC40A1
solute carrier family 40 (iron-regulated transporter), member 1
chr8_-_81083660 2.461 NM_001025253
NM_005079
TPD52

tumor protein D52

chr16_+_1359622 2.452 NM_003345
NM_194259
UBE2I

ubiquitin-conjugating enzyme E2I

chr5_+_153570270 2.449 NM_198321
GALNT10
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 10 (GalNAc-T10)
chr9_-_10612722 2.434 NM_002839
PTPRD
protein tyrosine phosphatase, receptor type, D
chr3_+_43328001 2.421 NM_001100594
NM_017719
SNRK

SNF related kinase

chr1_+_33004969 2.419 ZBTB8A
zinc finger and BTB domain containing 8A
chr1_-_55352881 2.400 DHCR24
24-dehydrocholesterol reductase
chr20_+_62887046 2.386 NM_001104925
NM_018257
PCMTD2

protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 2

chr10_+_35416089 2.386 CREM
cAMP responsive element modulator
chr2_+_173600634 2.373 RAPGEF4
Rap guanine nucleotide exchange factor (GEF) 4
chr10_-_131762017 2.372 NM_001005463
EBF3
early B-cell factor 3
chr2_-_190445521 2.368 NM_014585
SLC40A1
solute carrier family 40 (iron-regulated transporter), member 1
chr19_-_11373117 2.367 NM_020812
DOCK6
dedicator of cytokinesis 6
chr2_+_173600595 2.367 RAPGEF4
Rap guanine nucleotide exchange factor (GEF) 4
chr13_-_114566951 2.347 GAS6
growth arrest-specific 6
chr1_-_236228476 2.340 NM_002508
NID1
nidogen 1
chr21_-_35987144 2.329 NM_004414
RCAN1
regulator of calcineurin 1
chr16_+_81812897 2.323 NM_002661
PLCG2
phospholipase C, gamma 2 (phosphatidylinositol-specific)
chr3_+_141457110 2.317 RNF7
ring finger protein 7
chr1_+_77747602 2.315 NM_174858
AK5
adenylate kinase 5
chr12_+_96588000 2.300 NM_005230
ELK3
ELK3, ETS-domain protein (SRF accessory protein 2)
chr2_+_173600519 2.297 NM_007023
RAPGEF4
Rap guanine nucleotide exchange factor (GEF) 4
chr2_-_190445466 2.297 SLC40A1
solute carrier family 40 (iron-regulated transporter), member 1
chr1_+_221052845 2.289 HLX
H2.0-like homeobox
chr19_+_18530211 2.283 SSBP4
single stranded DNA binding protein 4
chr12_-_42983412 2.282 NM_153026
PRICKLE1
prickle homolog 1 (Drosophila)
chr17_+_5973640 2.280 NM_015253
WSCD1
WSC domain containing 1
chr11_-_124632050 2.276 NM_138961
ESAM
endothelial cell adhesion molecule
chr22_+_19705891 2.263 NM_001009939
SEPT5
septin 5
chr10_+_102106771 2.246 NM_005063
SCD
stearoyl-CoA desaturase (delta-9-desaturase)
chr8_-_28243589 2.241 ZNF395
zinc finger protein 395
chr11_+_926021 2.229 AP2A2
adaptor-related protein complex 2, alpha 2 subunit
chr15_-_102029872 2.228 PCSK6
proprotein convertase subtilisin/kexin type 6
chr2_+_238536183 2.227 NM_001137550
LRRFIP1
leucine rich repeat (in FLII) interacting protein 1
chr2_-_43453146 2.209 ZFP36L2
zinc finger protein 36, C3H type-like 2
chr14_+_105941061 2.204 NM_001312
CRIP2
cysteine-rich protein 2
chr22_-_19929250 2.196 TXNRD2
thioredoxin reductase 2
chr3_+_50192420 2.192 SEMA3F
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F
chr19_+_18530423 2.189


chr9_-_72287097 2.183 NM_001163
APBA1
amyloid beta (A4) precursor protein-binding, family A, member 1
chr11_+_68079999 2.183 NM_002335
LRP5
low density lipoprotein receptor-related protein 5
chr11_-_63536112 2.176 NM_001144936
C11orf95
chromosome 11 open reading frame 95
chr22_-_19929333 2.168 NM_006440
TXNRD2
thioredoxin reductase 2
chr17_+_40913233 2.161 RAMP2
receptor (G protein-coupled) activity modifying protein 2
chr17_-_76921205 2.145 TIMP2
TIMP metallopeptidase inhibitor 2
chr1_+_212459262 2.141 PPP2R5A
protein phosphatase 2, regulatory subunit B', alpha
chr17_+_78075299 2.135 NM_000152
NM_001079803
NM_001079804
GAA


glucosidase, alpha; acid


chr19_-_54693167 2.128 MBOAT7
membrane bound O-acyltransferase domain containing 7
chr19_-_19006868 2.127 NM_021267
NM_198207
NM_001492
CERS1

GDF1
ceramide synthase 1

growth differentiation factor 1
chr17_+_78075390 2.124 GAA
glucosidase, alpha; acid
chr5_-_179718963 2.079 MAPK9
mitogen-activated protein kinase 9
chr17_+_60705042 2.063 MRC2
mannose receptor, C type 2
chr18_+_9334820 2.054 TWSG1
twisted gastrulation homolog 1 (Drosophila)
chr19_-_54693414 2.054 MBOAT7
membrane bound O-acyltransferase domain containing 7
chr11_+_925899 2.053 AP2A2
adaptor-related protein complex 2, alpha 2 subunit
chr9_+_127020242 2.051 NEK6
NIMA (never in mitosis gene a)-related kinase 6
chr18_+_9334762 2.048 NM_020648
TWSG1
twisted gastrulation homolog 1 (Drosophila)
chr3_+_32280154 2.047 NM_178868
CMTM8
CKLF-like MARVEL transmembrane domain containing 8
chr21_+_18885296 2.044 CXADR
coxsackie virus and adenovirus receptor
chr7_-_752083 2.042 PRKAR1B
protein kinase, cAMP-dependent, regulatory, type I, beta
chr2_+_242498118 2.041 NM_032515
BOK
BCL2-related ovarian killer
chr9_-_80646150 2.035 NM_002072
GNAQ
guanine nucleotide binding protein (G protein), q polypeptide
chr13_-_114567040 2.034 NM_000820
GAS6
growth arrest-specific 6
chr1_+_65210724 2.030 NM_018211
RAVER2
ribonucleoprotein, PTB-binding 2
chr17_-_76921453 2.029 NM_003255
TIMP2
TIMP metallopeptidase inhibitor 2
chr6_+_11538486 2.020 NM_001100829
TMEM170B
transmembrane protein 170B
chr13_-_102068838 1.995 NALCN
sodium leak channel, non-selective
chr15_-_69113255 1.994 NM_006305
ANP32A
acidic (leucine-rich) nuclear phosphoprotein 32 family, member A
chr3_-_18466759 1.990 NM_001195470
NM_002971
SATB1

SATB homeobox 1

chr17_-_61523544 1.980 NM_001017916
NM_001915
CYB561

cytochrome b-561

chrX_+_152240726 1.971 NM_001170944
NM_001242319
NM_032882
PNMA6C
PNMA6D
PNMA6A
paraneoplastic antigen like 6C
paraneoplastic antigen like 6D
paraneoplastic antigen like 6A
chr3_-_15900928 1.970 NM_015199
ANKRD28
ankyrin repeat domain 28
chr17_-_76921076 1.965 TIMP2
TIMP metallopeptidase inhibitor 2
chr4_-_1722978 1.964 NM_001127266
NM_138385
TMEM129

transmembrane protein 129

chr1_-_205649537 1.964 SLC45A3
solute carrier family 45, member 3
chr7_+_130131921 1.963 NM_002402
MEST
mesoderm specific transcript homolog (mouse)
chr6_-_13486986 1.958 GFOD1
glucose-fructose oxidoreductase domain containing 1
chr14_-_30396811 1.952 NM_002742
PRKD1
protein kinase D1
chr17_+_60705051 1.948 MRC2
mannose receptor, C type 2
chr22_+_23522551 1.944 NM_004327
NM_021574
BCR

breakpoint cluster region

chr6_+_39760138 1.943


chr1_+_77747727 1.928 AK5
adenylate kinase 5
chr9_+_133971862 1.925 NM_001185095
NM_001185096
NM_031426
AIF1L


allograft inflammatory factor 1-like


chr12_+_96588254 1.924 ELK3
ELK3, ETS-domain protein (SRF accessory protein 2)
chr3_+_32280211 1.923 CMTM8
CKLF-like MARVEL transmembrane domain containing 8
chr12_+_2904289 1.921 FKBP4
FK506 binding protein 4, 59kDa
chr1_+_33722158 1.911 NM_152493
ZNF362
zinc finger protein 362
chr10_+_93170053 1.908


chr1_+_90098693 1.907 LRRC8C
leucine rich repeat containing 8 family, member C
chr3_+_50192847 1.899 NM_004186
SEMA3F
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F
chr9_-_140196702 1.899 NM_001004354
NRARP
NOTCH-regulated ankyrin repeat protein
chr19_-_41859332 1.890 TGFB1
transforming growth factor, beta 1
chr12_+_44229851 1.887 NM_032256
TMEM117
transmembrane protein 117

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.16 2.87e-12 GO:0044237 cellular metabolic process
1.08 3.96e-11 GO:0009987 cellular process
1.13 4.15e-10 GO:0008152 metabolic process
1.35 1.92e-09 GO:0007399 nervous system development
1.29 5.26e-09 GO:0043412 macromolecule modification
1.30 1.47e-08 GO:0006464 protein modification process
1.13 3.92e-08 GO:0044238 primary metabolic process
1.20 1.12e-06 GO:0048856 anatomical structure development
1.18 1.16e-06 GO:0032502 developmental process
1.20 2.96e-06 GO:0048731 system development
1.15 5.29e-06 GO:0044260 cellular macromolecule metabolic process
1.23 6.14e-06 GO:0048523 negative regulation of cellular process
1.17 1.30e-05 GO:0007275 multicellular organismal development
1.22 1.44e-05 GO:0048519 negative regulation of biological process
1.13 2.09e-04 GO:0043170 macromolecule metabolic process
1.27 2.41e-04 GO:0009966 regulation of signal transduction
1.24 2.89e-04 GO:0023051 regulation of signaling
1.31 7.52e-04 GO:0006793 phosphorus metabolic process
1.31 7.52e-04 GO:0006796 phosphate metabolic process
1.32 8.02e-04 GO:0048468 cell development
1.20 9.31e-04 GO:0048869 cellular developmental process
1.32 1.23e-03 GO:0022008 neurogenesis
1.30 1.43e-03 GO:0009892 negative regulation of metabolic process
1.18 1.89e-03 GO:0044267 cellular protein metabolic process
1.20 1.90e-03 GO:0030154 cell differentiation
1.18 2.07e-03 GO:0009058 biosynthetic process
1.59 2.27e-03 GO:0016567 protein ubiquitination
1.38 3.01e-03 GO:0010629 negative regulation of gene expression
1.56 3.33e-03 GO:0032446 protein modification by small protein conjugation
1.47 3.47e-03 GO:0000122 negative regulation of transcription from RNA polymerase II promoter
1.35 4.03e-03 GO:0009890 negative regulation of biosynthetic process
1.23 4.06e-03 GO:0009653 anatomical structure morphogenesis
1.30 4.11e-03 GO:0010605 negative regulation of macromolecule metabolic process
1.93 4.49e-03 GO:0040029 regulation of gene expression, epigenetic
1.31 5.52e-03 GO:0051128 regulation of cellular component organization
1.09 5.79e-03 GO:0050794 regulation of cellular process
1.17 7.28e-03 GO:0044249 cellular biosynthetic process
1.34 1.09e-02 GO:0010558 negative regulation of macromolecule biosynthetic process
1.15 1.15e-02 GO:0019538 protein metabolic process
1.34 1.16e-02 GO:0007167 enzyme linked receptor protein signaling pathway
1.31 1.54e-02 GO:0016192 vesicle-mediated transport
1.38 1.70e-02 GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
1.33 1.70e-02 GO:0031327 negative regulation of cellular biosynthetic process
1.37 1.71e-02 GO:0051253 negative regulation of RNA metabolic process
1.37 1.83e-02 GO:0045892 negative regulation of transcription, DNA-dependent
1.29 1.91e-02 GO:0048699 generation of neurons
1.08 1.94e-02 GO:0050789 regulation of biological process
1.22 2.44e-02 GO:0035556 intracellular signal transduction
1.07 2.88e-02 GO:0065007 biological regulation
1.34 3.26e-02 GO:0051172 negative regulation of nitrogen compound metabolic process
1.28 3.29e-02 GO:0031324 negative regulation of cellular metabolic process
1.34 3.30e-02 GO:0045934 negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.45 3.93e-02 GO:0070647 protein modification by small protein conjugation or removal
1.19 4.54e-02 GO:0044281 small molecule metabolic process
1.36 4.96e-02 GO:0007417 central nervous system development

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.11 1.83e-24 GO:0005622 intracellular
1.11 2.06e-23 GO:0044424 intracellular part
1.15 1.97e-21 GO:0005737 cytoplasm
1.11 9.06e-15 GO:0043229 intracellular organelle
1.11 1.18e-14 GO:0043226 organelle
1.12 1.36e-13 GO:0043231 intracellular membrane-bounded organelle
1.12 1.45e-13 GO:0043227 membrane-bounded organelle
1.16 7.79e-13 GO:0044444 cytoplasmic part
1.04 2.67e-06 GO:0044464 cell part
1.04 2.87e-06 GO:0005623 cell
1.29 3.77e-04 GO:0005794 Golgi apparatus
1.10 4.27e-04 GO:0005634 nucleus
1.19 5.50e-04 GO:0031090 organelle membrane
1.37 5.83e-04 GO:0044431 Golgi apparatus part
1.10 3.29e-03 GO:0044446 intracellular organelle part
1.68 4.03e-03 GO:0005912 adherens junction
1.64 4.36e-03 GO:0070161 anchoring junction
1.37 7.34e-03 GO:0000139 Golgi membrane
1.09 8.97e-03 GO:0044422 organelle part
1.19 1.04e-02 GO:0012505 endomembrane system
1.47 4.71e-02 GO:0016323 basolateral plasma membrane

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.08 1.25e-12 GO:0005488 binding
1.12 5.06e-10 GO:0005515 protein binding
1.52 1.40e-07 GO:0008092 cytoskeletal protein binding
1.14 4.15e-07 GO:0003824 catalytic activity
1.56 7.86e-05 GO:0003779 actin binding
1.14 2.00e-04 GO:0043167 ion binding
1.14 2.34e-04 GO:0043169 cation binding
1.14 3.29e-04 GO:0046872 metal ion binding
1.53 8.53e-04 GO:0016879 ligase activity, forming carbon-nitrogen bonds
1.51 2.61e-03 GO:0008134 transcription factor binding
1.53 3.42e-03 GO:0016881 acid-amino acid ligase activity
1.20 4.70e-03 GO:0016740 transferase activity
1.15 2.02e-02 GO:0000166 nucleotide binding
1.50 3.26e-02 GO:0019787 small conjugating protein ligase activity
1.51 3.43e-02 GO:0004842 ubiquitin-protein ligase activity