Motif ID: HLF.p2

Z-value: 0.735


Transcription factors associated with HLF.p2:

Gene SymbolEntrez IDGene Name
HLF 3131 hepatic leukemia factor

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.p-valuePlot
HLFchr17_+_533423560.154.9e-01Click!


Activity profile for motif HLF.p2.

activity profile for motif HLF.p2


Sorted Z-values histogram for motif HLF.p2

Sorted Z-values for motif HLF.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of HLF.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr16_+_57406398 4.602 NM_002996
CX3CL1
chemokine (C-X3-C motif) ligand 1
chr12_-_105322056 3.476 NM_032148
SLC41A2
solute carrier family 41, member 2
chr2_+_152214105 2.226 NM_007115
TNFAIP6
tumor necrosis factor, alpha-induced protein 6
chr19_+_45504686 2.007 NM_006509
RELB
v-rel reticuloendotheliosis viral oncogene homolog B
chr1_-_173174611 1.903 TNFSF4
tumor necrosis factor (ligand) superfamily, member 4
chr9_+_111624545 1.741 NM_006687
ACTL7A
actin-like 7A
chr4_+_74702272 1.609 NM_002993
CXCL6
chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2)
chr12_+_124773709 1.545 NM_181709
FAM101A
family with sequence similarity 101, member A
chr11_-_64647136 1.491 EHD1
EH-domain containing 1
chr12_-_117319231 1.235 NM_003806
HRK
harakiri, BCL2 interacting protein (contains only BH3 domain)
chr15_-_80263460 1.176 NM_001114735
NM_004049
BCL2A1

BCL2-related protein A1

chr6_-_169654047 1.158 NM_003247
THBS2
thrombospondin 2
chr5_-_58882274 1.148 NM_006203
PDE4D
phosphodiesterase 4D, cAMP-specific
chr18_+_61554938 1.129 NM_001143818
NM_002575
SERPINB2

serpin peptidase inhibitor, clade B (ovalbumin), member 2

chr6_-_169653922 1.092 THBS2
thrombospondin 2
chr1_-_8003224 1.088 NM_001561
TNFRSF9
tumor necrosis factor receptor superfamily, member 9
chr10_-_14372807 1.006 NM_018027
FRMD4A
FERM domain containing 4A
chr7_-_83824216 0.977 NM_006080
SEMA3A
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A
chr17_+_34431219 0.971 NM_002984
CCL4
chemokine (C-C motif) ligand 4
chr13_+_97928414 0.963 MBNL2
muscleblind-like 2 (Drosophila)
chr2_+_68694669 0.928 NM_173545
APLF
aprataxin and PNKP like factor
chr10_+_123923104 0.905 NM_006997
NM_206860
TACC2

transforming, acidic coiled-coil containing protein 2

chr1_-_154600383 0.846 ADAR
adenosine deaminase, RNA-specific
chr4_-_76928601 0.821 NM_002416
CXCL9
chemokine (C-X-C motif) ligand 9
chr4_-_76944585 0.820 NM_001565
CXCL10
chemokine (C-X-C motif) ligand 10
chr18_+_77866914 0.805 NM_014913
ADNP2
ADNP homeobox 2
chr1_-_154600446 0.734 NM_001025107
ADAR
adenosine deaminase, RNA-specific
chr19_+_41594367 0.719 NM_000766
CYP2A13
cytochrome P450, family 2, subfamily A, polypeptide 13
chr2_-_175712276 0.718 NM_001206602
CHN1
chimerin (chimaerin) 1
chr19_+_35849487 0.716 NM_005304
FFAR3
free fatty acid receptor 3
chr9_+_5510544 0.708 NM_025239
PDCD1LG2
programmed cell death 1 ligand 2
chr5_-_147162251 0.703 NM_014790
JAKMIP2
janus kinase and microtubule interacting protein 2
chr17_-_41623246 0.701 NM_001986
ETV4
ets variant 4
chr21_+_27011588 0.694 NM_021219
JAM2
junctional adhesion molecule 2
chr10_+_124151818 0.684 NM_021622
PLEKHA1
pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1
chr1_+_212738675 0.671 NM_001030287
ATF3
activating transcription factor 3
chr2_+_113885137 0.663 NM_173842
IL1RN
interleukin 1 receptor antagonist
chr19_+_10362886 0.659 MRPL4
mitochondrial ribosomal protein L4
chr6_+_7402879 0.654 NM_153005
RIOK1
RIO kinase 1 (yeast)
chr13_+_23755059 0.649 NM_000231
SGCG
sarcoglycan, gamma (35kDa dystrophin-associated glycoprotein)
chr2_+_108994366 0.646 NM_006588
SULT1C4
sulfotransferase family, cytosolic, 1C, member 4
chr10_+_70847817 0.631 NM_002727
SRGN
serglycin
chr1_+_168148082 0.622 NM_001031800
NM_152902
TIPRL

TIP41, TOR signaling pathway regulator-like (S. cerevisiae)

chr8_+_17396285 0.618 NM_001164771
NM_003046
SLC7A2

solute carrier family 7 (cationic amino acid transporter, y+ system), member 2

chr2_-_214015053 0.617 NM_016260
IKZF2
IKAROS family zinc finger 2 (Helios)
chr4_-_185747183 0.617 NM_001995
ACSL1
acyl-CoA synthetase long-chain family member 1
chr18_+_55888799 0.606 NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like
chrX_+_9431314 0.584 NM_001139466
NM_001139467
NM_001139468
TBL1X


transducin (beta)-like 1X-linked


chr10_+_103911932 0.577 NM_004741
NOLC1
nucleolar and coiled-body phosphoprotein 1
chr7_+_45933096 0.571


chr6_+_31940098 0.568 STK19
serine/threonine kinase 19
chr7_+_128349111 0.565 FAM71F1
family with sequence similarity 71, member F1
chr18_+_55888750 0.564 NM_001144966
NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like
chr4_-_153273683 0.560 NM_018315
FBXW7
F-box and WD repeat domain containing 7
chr5_-_121413906 0.547 LOX
lysyl oxidase
chr1_-_178840079 0.537 NM_004673
ANGPTL1
angiopoietin-like 1
chr12_-_4754275 0.537 NM_006422
AKAP3
A kinase (PRKA) anchor protein 3
chr2_+_113885145 0.530 IL1RN
interleukin 1 receptor antagonist
chr11_+_113775517 0.514 NM_006028
HTR3B
5-hydroxytryptamine (serotonin) receptor 3B
chr19_+_10362912 0.510 MRPL4
mitochondrial ribosomal protein L4
chr9_-_19786886 0.506 NM_001193288
NM_020344
SLC24A2

solute carrier family 24 (sodium/potassium/calcium exchanger), member 2

chr12_-_53074172 0.504 NM_006121
KRT1
keratin 1
chr5_-_121413967 0.490 LOX
lysyl oxidase
chr13_-_20110884 0.484 NM_001141968
NM_130785
NM_199254
TPTE2


transmembrane phosphoinositide 3-phosphatase and tensin homolog 2


chr2_+_228678556 0.482 NM_001130046
NM_004591
CCL20

chemokine (C-C motif) ligand 20

chr4_+_100485239 0.480 NM_000253
MTTP
microsomal triglyceride transfer protein
chr1_-_173176314 0.471 NM_003326
TNFSF4
tumor necrosis factor (ligand) superfamily, member 4
chr10_+_70847857 0.471 SRGN
serglycin
chr18_+_55816546 0.468 NM_001144965
NM_001144968
NM_001144969
NM_001144971
NEDD4L



neural precursor cell expressed, developmentally down-regulated 4-like



chr19_-_54604070 0.468 NM_130771
NM_133168
NM_133169
NM_206818
OSCAR



osteoclast associated, immunoglobulin-like receptor



chr21_+_19617145 0.464 NM_024944
CHODL
chondrolectin
chr10_-_45474210 0.462 NM_007021
C10orf10
chromosome 10 open reading frame 10
chr1_+_11249344 0.460 NM_021146
ANGPTL7
angiopoietin-like 7
chr4_-_185747051 0.457 ACSL1
acyl-CoA synthetase long-chain family member 1
chr14_+_96671015 0.451 NM_000623
BDKRB2
bradykinin receptor B2
chr9_-_2844098 0.448 NM_014878
KIAA0020
KIAA0020
chrX_+_15518899 0.442 NM_203281
BMX
BMX non-receptor tyrosine kinase
chr16_-_75657153 0.439 NM_012091
ADAT1
adenosine deaminase, tRNA-specific 1
chr2_+_30454396 0.434 NM_030915
LBH
limb bud and heart development homolog (mouse)
chr9_-_2844083 0.433 KIAA0020
KIAA0020
chr7_-_45026204 0.430 SNHG15
small nucleolar RNA host gene 15 (non-protein coding)
chr2_-_31637553 0.426 XDH
xanthine dehydrogenase
chr5_-_160279045 0.419 NM_025153
ATP10B
ATPase, class V, type 10B
chr10_+_64893003 0.418 NM_030759
NRBF2
nuclear receptor binding factor 2
chr21_+_45138987 0.417 PDXK
pyridoxal (pyridoxine, vitamin B6) kinase
chr2_+_219745243 0.416 NM_025216
WNT10A
wingless-type MMTV integration site family, member 10A
chr5_-_94417544 0.410 NM_001002796
MCTP1
multiple C2 domains, transmembrane 1
chr12_-_88423145 0.410 NM_152589
C12orf50
chromosome 12 open reading frame 50
chr15_+_42840991 0.404 NM_001130447
NM_018097
HAUS2

HAUS augmin-like complex, subunit 2

chr8_+_120079423 0.401 NM_006438
COLEC10
collectin sub-family member 10 (C-type lectin)
chr19_+_49259343 0.401 NM_019113
FGF21
fibroblast growth factor 21
chrX_-_40506666 0.398 CXorf38
chromosome X open reading frame 38
chr20_+_62496634 0.376 TPD52L2
tumor protein D52-like 2
chr20_+_62496650 0.375 TPD52L2
tumor protein D52-like 2
chr6_-_13295817 0.372 NM_001242698
LOC100130357
uncharacterized LOC100130357
chr20_+_36011936 0.359 SRC
v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)
chr21_+_45138973 0.354 NM_003681
PDXK
pyridoxal (pyridoxine, vitamin B6) kinase
chrX_+_110339374 0.349 NM_002578
PAK3
p21 protein (Cdc42/Rac)-activated kinase 3
chr5_-_147162264 0.345 JAKMIP2
janus kinase and microtubule interacting protein 2
chr20_+_62496678 0.343 TPD52L2
tumor protein D52-like 2
chr12_+_112856756 0.342 PTPN11
protein tyrosine phosphatase, non-receptor type 11
chr18_+_55888838 0.340 NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like
chr1_+_168148215 0.339 TIPRL
TIP41, TOR signaling pathway regulator-like (S. cerevisiae)
chr8_+_124194873 0.337 FAM83A
family with sequence similarity 83, member A
chrX_+_65235279 0.337


chr3_-_99594915 0.333 NM_014890
FILIP1L
filamin A interacting protein 1-like
chr7_+_28725597 0.333 NM_001011666
CREB5
cAMP responsive element binding protein 5
chr10_+_114043413 0.332 NM_058222
TECTB
tectorin beta
chr17_-_55980749 0.327 NM_017949
CUEDC1
CUE domain containing 1
chr9_-_73029539 0.326 NM_001206
KLF9
Kruppel-like factor 9
chr9_-_95055966 0.325 NM_013417
IARS
isoleucyl-tRNA synthetase
chr14_-_77889231 0.324 NM_001113475
NOXRED1
NADP-dependent oxidoreductase domain containing 1
chr7_-_31380507 0.320 NM_022728
NEUROD6
neurogenic differentiation 6
chr5_-_138718941 0.318 SLC23A1
solute carrier family 23 (nucleobase transporters), member 1
chr11_-_14993790 0.316 NM_001033952
NM_001033953
NM_001741
CALCA


calcitonin-related polypeptide alpha


chr3_-_15382874 0.312 NM_001018009
SH3BP5
SH3-domain binding protein 5 (BTK-associated)
chr7_-_112727832 0.312 NM_001146265
NM_018970
GPR85

G protein-coupled receptor 85

chr12_-_123380608 0.310


chr10_+_91152321 0.310 NM_001548
IFIT1
interferon-induced protein with tetratricopeptide repeats 1
chr1_-_21501229 0.308 NM_001198803
EIF4G3
eukaryotic translation initiation factor 4 gamma, 3
chr2_-_113594325 0.307 NM_000576
IL1B
interleukin 1, beta
chr6_-_90024936 0.307 NM_002043
GABRR2
gamma-aminobutyric acid (GABA) receptor, rho 2
chr3_-_185655776 0.289 TRA2B
transformer 2 beta homolog (Drosophila)
chr20_+_58296264 0.283 NM_183244
NM_183246
PHACTR3

phosphatase and actin regulator 3

chr15_-_83621350 0.279 NM_004839
NM_199330
HOMER2

homer homolog 2 (Drosophila)

chr9_-_35958095 0.278 NM_019897
OR2S2
olfactory receptor, family 2, subfamily S, member 2
chr21_-_30365111 0.277 NM_015565
LTN1
listerin E3 ubiquitin protein ligase 1
chr9_-_95055986 0.277 IARS
isoleucyl-tRNA synthetase
chr8_+_38585703 0.276 NM_001146216
TACC1
transforming, acidic coiled-coil containing protein 1
chr11_+_5372737 0.276 NM_001004750
OR51B6
olfactory receptor, family 51, subfamily B, member 6
chr19_+_49109999 0.276 NM_133498
SPACA4
sperm acrosome associated 4
chr2_+_191002485 0.276 NM_001042521
C2orf88
chromosome 2 open reading frame 88
chr20_+_55099784 0.273 NM_001012971
FAM209A
FAM209B
family with sequence similarity 209, member A
family with sequence similarity 209, member B
chr1_-_32264271 0.272 SPOCD1
SPOC domain containing 1
chr5_-_94417185 0.271 MCTP1
multiple C2 domains, transmembrane 1
chr1_-_213020947 0.271 NM_001024601
C1orf227
chromosome 1 open reading frame 227
chr8_-_145115565 0.267 NM_017570
OPLAH
5-oxoprolinase (ATP-hydrolysing)
chr11_+_5710926 0.266 TRIM22
tripartite motif containing 22
chr13_-_25746304 0.266 FAM123A
family with sequence similarity 123A
chr7_+_90032647 0.264 NM_001185072
NM_001185073
NM_012129
CLDN12


claudin 12


chr6_-_43595079 0.263 GTPBP2
GTP binding protein 2
chr5_-_138719018 0.262 NM_005847
NM_152685
SLC23A1

solute carrier family 23 (nucleobase transporters), member 1

chr3_-_138478184 0.262 NM_006219
PIK3CB
phosphoinositide-3-kinase, catalytic, beta polypeptide
chr10_+_86004808 0.261 NM_001012720
NM_001012722
NM_002921
RGR


retinal G protein coupled receptor


chr3_-_16306283 0.261 NM_001047434
NM_206831
DPH3

DPH3, KTI11 homolog (S. cerevisiae)

chr8_+_24298442 0.260 NM_003817
ADAM7
ADAM metallopeptidase domain 7
chr17_-_49124128 0.257 NM_001251971
SPAG9
sperm associated antigen 9
chr17_-_34329083 0.256 NM_032965
CCL15
chemokine (C-C motif) ligand 15
chr5_-_32388595 0.255 ZFR
zinc finger RNA binding protein
chr17_+_51900238 0.255 NM_032559
KIF2B
kinesin family member 2B
chr12_-_54758228 0.254 NM_020370
GPR84
G protein-coupled receptor 84
chr16_+_20911987 0.250 NM_001128301
NM_001128302
LYRM1

LYR motif containing 1

chr18_+_77867145 0.249 ADNP2
ADNP homeobox 2
chr22_-_43355886 0.249 NM_001184971
PACSIN2
protein kinase C and casein kinase substrate in neurons 2
chr17_+_74536114 0.249 NM_001077620
PRCD
progressive rod-cone degeneration
chr5_+_95998170 0.248 CAST
calpastatin
chr19_+_36119958 0.247 NM_024321
RBM42
RNA binding motif protein 42
chr7_-_115670774 0.246 TFEC
transcription factor EC
chr12_+_57623355 0.240 NM_001166356
NM_005412
SHMT2

serine hydroxymethyltransferase 2 (mitochondrial)

chr14_+_21249209 0.240 NM_005615
RNASE6
ribonuclease, RNase A family, k6
chr14_-_63785592 0.240 NM_145171
GPHB5
glycoprotein hormone beta 5
chr10_+_118305427 0.239 NM_000936
PNLIP
pancreatic lipase
chr6_-_114384008 0.236 NM_153612
HS3ST5
heparan sulfate (glucosamine) 3-O-sulfotransferase 5
chr17_-_17485691 0.235 PEMT
phosphatidylethanolamine N-methyltransferase
chr19_+_49622480 0.233 NM_003660
PPFIA3
protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 3
chr10_+_114133775 0.232 ACSL5
acyl-CoA synthetase long-chain family member 5
chr5_-_39364562 0.232 NM_001737
C9
complement component 9
chr9_+_36169384 0.230 NM_005893
CCIN
calicin
chr7_-_112727778 0.229 GPR85
G protein-coupled receptor 85
chr12_-_16757944 0.229 LMO3
LIM domain only 3 (rhombotin-like 2)
chr22_-_30867944 0.228 NM_174975
SEC14L3
SEC14-like 3 (S. cerevisiae)
chr20_-_44420538 0.228 NM_080614
WFDC3
WAP four-disulfide core domain 3
chr12_-_75603510 0.227 NM_139136
NM_139137
NM_153748
KCNC2


potassium voltage-gated channel, Shaw-related subfamily, member 2


chr21_+_45209398 0.226 NM_003683
RRP1
ribosomal RNA processing 1 homolog (S. cerevisiae)
chr8_-_101315457 0.226 NM_015435
RNF19A
ring finger protein 19A
chrX_-_40506800 0.225 NM_144970
CXorf38
chromosome X open reading frame 38
chr13_-_25745620 0.225 FAM123A
family with sequence similarity 123A
chr2_-_73869493 0.224 NM_003960
NAT8
N-acetyltransferase 8 (GCN5-related, putative)
chr20_+_44420606 0.223 DNTTIP1
deoxynucleotidyltransferase, terminal, interacting protein 1
chr17_+_685512 0.220 NM_018146
RNMTL1
RNA methyltransferase like 1
chr3_-_195306274 0.219 APOD
apolipoprotein D
chr7_-_112727799 0.218 GPR85
G protein-coupled receptor 85
chr11_-_77184549 0.218 NM_001128620
NM_002576
PAK1

p21 protein (Cdc42/Rac)-activated kinase 1

chr1_-_93342706 0.216 NM_001252271
FAM69A
family with sequence similarity 69, member A
chr9_-_114247024 0.215 NM_001080398
KIAA0368
KIAA0368
chr11_+_69061599 0.215 NM_138768
MYEOV
myeloma overexpressed (in a subset of t(11;14) positive multiple myelomas)
chr1_+_209878135 0.215 NM_005525
HSD11B1
hydroxysteroid (11-beta) dehydrogenase 1
chr17_-_39324423 0.213 NM_033187
KRTAP4-3
keratin associated protein 4-3
chr1_-_102462789 0.213 NM_058170
OLFM3
olfactomedin 3
chr2_-_114514196 0.213 NM_025181
SLC35F5
solute carrier family 35, member F5
chr1_-_100643770 0.213 NM_144620
LRRC39
leucine rich repeat containing 39
chr19_+_55014012 0.212 NM_002288
NM_021270
LAIR2

leukocyte-associated immunoglobulin-like receptor 2

chr9_-_94186140 0.208 NM_005384
NFIL3
nuclear factor, interleukin 3 regulated
chr21_+_35736322 0.208 NM_172201
KCNE2
potassium voltage-gated channel, Isk-related family, member 2
chr2_+_162272892 0.207 TBR1
T-box, brain, 1
chr6_+_131894343 0.205 NM_000045
NM_001244438
ARG1

arginase, liver

chr19_-_35992798 0.205 NM_001035516
DMKN
dermokine
chr12_+_57623827 0.205 NM_001166358
NM_001166359
NM_001166357
SHMT2


serine hydroxymethyltransferase 2 (mitochondrial)


chr13_-_25745778 0.202 NM_152704
NM_199138
FAM123A

family with sequence similarity 123A

chr5_+_6746100 0.200 NM_001171806
PAPD7
PAP associated domain containing 7

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
16.87 5.35e-05 GO:0060600 dichotomous subdivision of an epithelial terminal unit
19.88 1.30e-04 GO:0060678 dichotomous subdivision of terminal units involved in ureteric bud branching
17.68 3.79e-04 GO:0048880 sensory system development
17.68 3.79e-04 GO:0048892 lateral line nerve development
17.68 3.79e-04 GO:0048895 lateral line nerve glial cell differentiation
17.68 3.79e-04 GO:0048925 lateral line system development
17.68 3.79e-04 GO:0048937 lateral line nerve glial cell development
17.68 3.79e-04 GO:0050935 iridophore differentiation
12.37 9.15e-04 GO:0048485 sympathetic nervous system development
13.26 3.78e-03 GO:0048846 axon extension involved in axon guidance
13.26 3.78e-03 GO:0090184 positive regulation of kidney development
8.84 1.36e-02 GO:0030318 melanocyte differentiation
8.84 1.36e-02 GO:0050931 pigment cell differentiation
10.61 1.86e-02 GO:0030513 positive regulation of BMP signaling pathway
10.61 1.86e-02 GO:0048484 enteric nervous system development
7.07 1.93e-02 GO:0048066 developmental pigmentation
1.76 3.11e-02 GO:0009605 response to external stimulus
1.79 3.35e-02 GO:0009611 response to wounding

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.96 3.87e-04 GO:0005615 extracellular space
1.73 4.11e-03 GO:0044421 extracellular region part
1.46 1.00e-02 GO:0005576 extracellular region

Gene overrepresentation in function category:

enrichment   p-value GO term description
5.76 2.80e-03 GO:0008009 chemokine activity
5.20 7.41e-03 GO:0042379 chemokine receptor binding