Motif ID: HMGA1,2.p2

Z-value: 1.325


Transcription factors associated with HMGA1,2.p2:

Gene SymbolEntrez IDGene Name
HMGA1 3159 high mobility group AT-hook 1
HMGA2 8091 high mobility group AT-hook 2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.p-valuePlot
HMGA2chr12_+_662181410.645.5e-04Click!
HMGA1chr6_+_342046900.491.3e-02Click!


Activity profile for motif HMGA1,2.p2.

activity profile for motif HMGA1,2.p2


Sorted Z-values histogram for motif HMGA1,2.p2

Sorted Z-values for motif HMGA1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of HMGA1,2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr1_+_79115476 5.958 NM_006417
IFI44
interferon-induced protein 44
chr1_+_79086087 4.821 NM_006820
IFI44L
interferon-induced protein 44-like
chr11_-_102651321 4.781 NM_002425
MMP10
matrix metallopeptidase 10 (stromelysin 2)
chr17_-_34207308 3.448 NM_002985
CCL5
chemokine (C-C motif) ligand 5
chr3_-_78666943 3.434 ROBO1
roundabout, axon guidance receptor, homolog 1 (Drosophila)
chr5_-_58571916 3.371 NM_001197220
PDE4D
phosphodiesterase 4D, cAMP-specific
chr9_+_127420690 3.285 MIR181A2HG
MIR181A2 host gene (non-protein coding)
chr3_-_79817058 3.161 NM_002941
ROBO1
roundabout, axon guidance receptor, homolog 1 (Drosophila)
chr7_-_115670774 3.034 TFEC
transcription factor EC
chr1_-_150738292 2.807 NM_001199739
NM_004079
CTSS

cathepsin S

chr2_+_152214105 2.778 NM_007115
TNFAIP6
tumor necrosis factor, alpha-induced protein 6
chr4_+_74347461 2.718 NM_001133
AFM
afamin
chr17_+_41158741 2.692 NM_005533
IFI35
interferon-induced protein 35
chr5_+_35856990 2.689 NM_002185
IL7R
interleukin 7 receptor
chr1_-_150738232 2.545 CTSS
cathepsin S
chr7_-_92777657 2.513 NM_152703
SAMD9L
sterile alpha motif domain containing 9-like
chr1_-_150738255 2.501 CTSS
cathepsin S
chr7_-_115670828 2.226 NM_001018058
NM_012252
TFEC

transcription factor EC

chr12_-_10151689 2.120 NM_001099431
NM_016509
CLEC1B

C-type lectin domain family 1, member B

chr19_-_49220213 2.082 NM_182574
MAMSTR
MEF2 activating motif and SAP domain containing transcriptional regulator
chr1_-_89488412 2.018 NM_018284
GBP3
guanylate binding protein 3
chr13_-_33780142 1.973 NM_001243474
NM_052851
STARD13

StAR-related lipid transfer (START) domain containing 13

chr6_+_127898318 1.964 NM_001010905
C6orf58
chromosome 6 open reading frame 58
chr2_+_103035148 1.924 NM_003853
IL18RAP
interleukin 18 receptor accessory protein
chr12_+_78225068 1.905 NM_014903
NAV3
neuron navigator 3
chr11_-_104972147 1.816 NM_001007232
NM_001223
NM_033292
NM_033293
NM_033294
NM_033295
CARD17
CASP1




caspase recruitment domain family, member 17
caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)




chr5_-_160279045 1.799 NM_025153
ATP10B
ATPase, class V, type 10B
chr5_+_161494647 1.782 NM_000816
NM_198903
NM_198904
GABRG2


gamma-aminobutyric acid (GABA) A receptor, gamma 2


chr4_-_76957139 1.738 NM_005409
CXCL11
chemokine (C-X-C motif) ligand 11
chr5_+_96211643 1.691 NM_001130140
NM_022350
ERAP2

endoplasmic reticulum aminopeptidase 2

chr4_+_186990308 1.654 NM_003265
TLR3
toll-like receptor 3
chr6_+_132891460 1.653 NM_175067
TAAR6
trace amine associated receptor 6
chr11_+_69455837 1.604 NM_053056
CCND1
cyclin D1
chr19_-_17958773 1.597 JAK3
Janus kinase 3
chr1_-_209825797 1.584 NM_000228
LAMB3
laminin, beta 3
chr12_+_113344738 1.531 NM_001032409
NM_002534
NM_016816
OAS1


2'-5'-oligoadenylate synthetase 1, 40/46kDa


chr17_-_48945338 1.500 NM_001243877
TOB1
transducer of ERBB2, 1
chr1_-_149908759 1.489 NM_001145862
MTMR11
myotubularin related protein 11
chr10_+_91087601 1.479 NM_001549
IFIT3
interferon-induced protein with tetratricopeptide repeats 3
chr11_+_131240370 1.478 NM_001048209
NTM
neurotrimin
chr2_+_169757749 1.459 NM_001081686
NM_021176
G6PC2

glucose-6-phosphatase, catalytic, 2

chr1_+_15986363 1.430 NM_006511
RSC1A1
regulatory solute carrier protein, family 1, member 1
chr11_-_5173598 1.395 NM_012375
OR52A1
olfactory receptor, family 52, subfamily A, member 1
chr10_+_91092238 1.387 NM_001031683
IFIT3
interferon-induced protein with tetratricopeptide repeats 3
chr3_-_79068542 1.383 NM_001145845
NM_133631
ROBO1

roundabout, axon guidance receptor, homolog 1 (Drosophila)

chr11_-_114466471 1.364 NM_001077639
NM_017678
FAM55D

family with sequence similarity 55, member D

chr1_-_163113938 1.355 RGS5
regulator of G-protein signaling 5
chr7_-_41742666 1.326 NM_002192
INHBA
inhibin, beta A
chr1_-_173176314 1.321 NM_003326
TNFSF4
tumor necrosis factor (ligand) superfamily, member 4
chr13_+_108955763 1.297


chr1_-_149908721 1.271 MTMR11
myotubularin related protein 11
chr19_-_4338750 1.251 NM_001013841
NM_017720
STAP2

signal transducing adaptor family member 2

chr4_+_169013687 1.248 NM_007193
ANXA10
annexin A10
chr17_-_67240955 1.243 NM_080282
ABCA10
ATP-binding cassette, sub-family A (ABC1), member 10
chr2_-_100046262 1.229 REV1
REV1 homolog (S. cerevisiae)
chr9_+_74920329 1.206


chr6_-_134639195 1.200 NM_001143676
SGK1
serum/glucocorticoid regulated kinase 1
chr11_+_5710926 1.199 TRIM22
tripartite motif containing 22
chr5_+_304290 1.195 NM_001242412
NM_020731
AHRR

aryl-hydrocarbon receptor repressor

chr10_-_62332666 1.188 NM_001204404
ANK3
ankyrin 3, node of Ranvier (ankyrin G)
chr7_+_18548899 1.186 NM_001204147
NM_001204148
HDAC9

histone deacetylase 9

chr2_-_231084600 1.182 NM_004509
NM_004510
NM_080424
SP110


SP110 nuclear body protein


chr10_+_91152321 1.140 NM_001548
IFIT1
interferon-induced protein with tetratricopeptide repeats 1
chr2_+_29038862 1.127 NM_001008779
SPDYA
speedy homolog A (Xenopus laevis)
chr2_+_36923902 1.121 VIT
vitrin
chr4_+_100495972 1.113 MTTP
microsomal triglyceride transfer protein
chr4_-_169401603 1.110 NM_001012967
DDX60L
DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like
chr3_+_107096187 1.103 NM_032600
CCDC54
coiled-coil domain containing 54
chr4_-_70826712 1.066 NM_001891
CSN2
casein beta
chr3_+_171561138 1.062 NM_001164436
TMEM212
transmembrane protein 212
chr1_-_173174611 1.050 TNFSF4
tumor necrosis factor (ligand) superfamily, member 4
chr10_-_118680978 1.038 KIAA1598
KIAA1598
chr1_+_116654375 1.035 NM_152367
MAB21L3
mab-21-like 3 (C. elegans)
chr3_-_123339178 1.028 MYLK
myosin light chain kinase
chr3_+_122399665 1.028 NM_017554
PARP14
poly (ADP-ribose) polymerase family, member 14
chr5_-_58652671 1.023 NM_001197219
PDE4D
phosphodiesterase 4D, cAMP-specific
chr6_-_43595046 1.020 GTPBP2
GTP binding protein 2
chr2_+_102953716 1.020 NM_003856
IL1RL1
interleukin 1 receptor-like 1
chr1_-_89664510 1.014 NM_052941
GBP4
guanylate binding protein 4
chr5_-_58295758 1.014 NM_001197223
PDE4D
phosphodiesterase 4D, cAMP-specific
chr2_-_37374948 1.009 NM_001135652
EIF2AK2
eukaryotic translation initiation factor 2-alpha kinase 2
chr11_-_102496049 1.005 NM_004771
MMP20
matrix metallopeptidase 20
chr10_+_70847857 0.992 SRGN
serglycin
chr11_-_67450536 0.984 RPL37
ribosomal protein L37
chr15_+_71839540 0.983 THSD4
thrombospondin, type I, domain containing 4
chr9_+_5510544 0.981 NM_025239
PDCD1LG2
programmed cell death 1 ligand 2
chr11_-_6817013 0.981 NM_003696
OR6A2
olfactory receptor, family 6, subfamily A, member 2
chr22_+_18632704 0.963 NM_017414
USP18
ubiquitin specific peptidase 18
chr3_+_97158453 0.959 NM_173655
EPHA6
EPH receptor A6
chr1_-_32281577 0.956 NM_144569
SPOCD1
SPOC domain containing 1
chr11_-_85430117 0.953 NM_206929
SYTL2
synaptotagmin-like 2
chrX_+_91089658 0.947 NM_014522
NM_032968
NM_032969
PCDH11X


protocadherin 11 X-linked


chr2_-_175712276 0.935 NM_001206602
CHN1
chimerin (chimaerin) 1
chr1_+_50571963 0.925 NM_001144775
ELAVL4
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)
chr4_-_76928601 0.913 NM_002416
CXCL9
chemokine (C-X-C motif) ligand 9
chr1_-_161337663 0.911 NM_001013625
C1orf192
chromosome 1 open reading frame 192
chr3_-_112693711 0.907 NM_138806
NM_138939
NM_138940
NM_170780
CD200R1



CD200 receptor 1



chr3_+_151531860 0.895 NM_001086
AADAC
arylacetamide deacetylase (esterase)
chr15_+_71433787 0.886 NM_024817
THSD4
thrombospondin, type I, domain containing 4
chr14_-_91710851 0.873 NM_001177676
GPR68
G protein-coupled receptor 68
chr19_-_43690558 0.863 NM_001130014
NM_002781
PSG5

pregnancy specific beta-1-glycoprotein 5

chr2_+_102508377 0.858 MAP4K4
mitogen-activated protein kinase kinase kinase kinase 4
chr12_+_9980076 0.855 NM_016523
KLRF1
killer cell lectin-like receptor subfamily F, member 1
chr13_+_98605928 0.846 NM_002271
IPO5
importin 5
chr6_-_53013581 0.838 NM_003643
GCM1
glial cells missing homolog 1 (Drosophila)
chr5_-_150603615 0.836 CCDC69
coiled-coil domain containing 69
chr2_+_168043792 0.833 NM_001199144
NM_001199145
XIRP2

xin actin-binding repeat containing 2

chr10_+_70847817 0.833 NM_002727
SRGN
serglycin
chr5_-_150603649 0.826 NM_015621
CCDC69
coiled-coil domain containing 69
chr12_+_9822205 0.824 NM_001197318
NM_013269
NM_001004419
NM_001197317
NM_001197319
CLEC2D




C-type lectin domain family 2, member D




chr5_-_35938736 0.823 NM_001042625
NM_144647
CAPSL

calcyphosine-like

chr15_-_80263460 0.818 NM_001114735
NM_004049
BCL2A1

BCL2-related protein A1

chr4_-_80994309 0.816 NM_001145794
NM_058172
ANTXR2

anthrax toxin receptor 2

chrX_+_52928408 0.810 NM_001099684
FAM156A
FAM156B
family with sequence similarity 156, member A
family with sequence similarity 156, member B
chr1_-_154578775 0.807 NM_001193495
ADAR
adenosine deaminase, RNA-specific
chr16_+_56817367 0.798 NM_001242796
NUP93
nucleoporin 93kDa
chr5_+_40909558 0.789 NM_000587
C7
complement component 7
chrX_-_52985628 0.787 NM_001099684
FAM156A
FAM156B
family with sequence similarity 156, member A
family with sequence similarity 156, member B
chr18_+_72167021 0.785 CNDP2
CNDP dipeptidase 2 (metallopeptidase M20 family)
chr1_+_84864214 0.782 NM_021233
DNASE2B
deoxyribonuclease II beta
chr1_+_198608244 0.779 PTPRC
protein tyrosine phosphatase, receptor type, C
chr4_+_15429628 0.774 NM_031911
C1QTNF7
C1q and tumor necrosis factor related protein 7
chr20_+_53092131 0.769 NM_018431
DOK5
docking protein 5
chr20_+_9494995 0.767 NM_001199897
NM_012261
LAMP5

lysosomal-associated membrane protein family, member 5

chr2_+_231281470 0.759 NM_001206704
SP100
SP100 nuclear antigen
chr12_+_56075329 0.758 NM_152637
METTL7B
methyltransferase like 7B
chr5_+_156696351 0.747 NM_014376
CYFIP2
cytoplasmic FMR1 interacting protein 2
chr20_+_58251715 0.745 NM_001199506
PHACTR3
phosphatase and actin regulator 3
chr20_-_8000446 0.738 TMX4
thioredoxin-related transmembrane protein 4
chr2_+_102508333 0.734 MAP4K4
mitogen-activated protein kinase kinase kinase kinase 4
chr12_+_64803741 0.730 XPOT
exportin, tRNA (nuclear export receptor for tRNAs)
chr5_+_40909617 0.730 C7
complement component 7
chr1_-_8003224 0.729 NM_001561
TNFRSF9
tumor necrosis factor receptor superfamily, member 9
chr1_-_247921707 0.727 NM_012353
OR1C1
olfactory receptor, family 1, subfamily C, member 1
chr3_+_132036276 0.724 ACPP
acid phosphatase, prostate
chr6_+_29274402 0.724 NM_030946
OR14J1
olfactory receptor, family 14, subfamily J, member 1
chr2_-_174767282 0.723


chr21_+_43619798 0.723 NM_207627
NM_207628
ABCG1

ATP-binding cassette, sub-family G (WHITE), member 1

chrX_-_11284094 0.723 NM_013423
ARHGAP6
Rho GTPase activating protein 6
chr8_+_144731829 0.720 NM_014789
ZNF623
zinc finger protein 623
chr5_-_24645084 0.720 NM_006727
CDH10
cadherin 10, type 2 (T2-cadherin)
chr3_+_98072697 0.718 NM_001005517
OR5K4
olfactory receptor, family 5, subfamily K, member 4
chr12_+_21168629 0.718 NM_001009562
SLCO1B7
solute carrier organic anion transporter family, member 1B7 (non-functional)
chr1_+_244216506 0.718 NM_006352
ZNF238
zinc finger protein 238
chr3_+_151488214 0.716 LOC201651
arylacetamide deacetylase (esterase) pseudogene
chr4_-_153273683 0.713 NM_018315
FBXW7
F-box and WD repeat domain containing 7
chr6_+_64286348 0.709 PTP4A1
protein tyrosine phosphatase type IVA, member 1
chr1_+_167599329 0.702 NM_052862
RCSD1
RCSD domain containing 1
chr14_+_21525980 0.700 NM_138331
RNASE8
ribonuclease, RNase A family, 8
chr1_-_7913094 0.698 NM_006786
UTS2
urotensin 2
chr12_-_95945226 0.692 NM_032147
USP44
ubiquitin specific peptidase 44
chr11_-_8832881 0.680 NM_139157
ST5
suppression of tumorigenicity 5
chr7_-_92747317 0.680 NM_001193307
NM_017654
SAMD9

sterile alpha motif domain containing 9

chr21_+_27011766 0.676 JAM2
junctional adhesion molecule 2
chr1_-_157811491 0.676 NM_005894
CD5L
CD5 molecule-like
chr8_+_36641841 0.671 NM_001031836
KCNU1
potassium channel, subfamily U, member 1
chrX_+_38211735 0.668 NM_000531
OTC
ornithine carbamoyltransferase
chr4_+_86851425 0.667 NM_031305
ARHGAP24
Rho GTPase activating protein 24
chr12_-_102872329 0.663 NM_001111284
IGF1
insulin-like growth factor 1 (somatomedin C)
chr1_+_10490158 0.660 NM_198544
NM_199006
NM_199294
APITD1-CORT

APITD1
APITD1-CORT readthrough

apoptosis-inducing, TAF9-like domain 1
chr6_-_64029847 0.660 NM_001143940
NM_016571
LGSN

lengsin, lens protein with glutamine synthetase domain

chr3_-_71294229 0.660 NM_001244814
FOXP1
forkhead box P1
chr12_+_62954275 0.659 MON2
MON2 homolog (S. cerevisiae)
chr14_+_94577078 0.659 NM_001130080
NM_005532
IFI27

interferon, alpha-inducible protein 27

chr6_+_26365397 0.659 NM_001197247
NM_001197249
NM_007047
NM_001197248
BTN3A2



butyrophilin, subfamily 3, member A2



chr6_+_26440699 0.658 NM_001242803
NM_006994
NM_197974
BTN3A3


butyrophilin, subfamily 3, member A3


chr3_+_155838336 0.656 NM_172160
KCNAB1
potassium voltage-gated channel, shaker-related subfamily, beta member 1
chr4_+_72102249 0.654 SLC4A4
solute carrier family 4, sodium bicarbonate cotransporter, member 4
chrX_+_50027539 0.654 NM_033031
NM_033670
CCNB3

cyclin B3

chr5_-_131879172 0.651 NM_000879
IL5
interleukin 5 (colony-stimulating factor, eosinophil)
chr3_-_167191808 0.650 NM_006217
SERPINI2
serpin peptidase inhibitor, clade I (pancpin), member 2
chr3_-_42843217 0.649


chr18_+_32290195 0.648 NM_001198941
NM_032978
DTNA

dystrobrevin, alpha

chr16_-_54962707 0.644 CRNDE
colorectal neoplasia differentially expressed (non-protein coding)
chrX_+_65384078 0.644 NM_001130860
NM_014799
HEPH

hephaestin

chr18_+_32397925 0.634 NM_001198943
DTNA
dystrobrevin, alpha
chr16_+_72042486 0.632 NM_001361
DHODH
dihydroorotate dehydrogenase (quinone)
chr1_+_50569581 0.629 NM_001144776
ELAVL4
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)
chr13_-_46679143 0.626 NM_001872
NM_016413
CPB2

carboxypeptidase B2 (plasma)

chr18_+_616671 0.625 NM_199167
CLUL1
clusterin-like 1 (retinal)
chr11_-_104905849 0.621 CASP1
caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)
chr1_+_202431870 0.618 NM_032103
NM_032104
PPP1R12B

protein phosphatase 1, regulatory subunit 12B

chr2_-_224467049 0.617 SCG2
secretogranin II
chr19_+_41725277 0.615 AXL
AXL receptor tyrosine kinase
chr5_-_150467220 0.613 NM_001252390
TNIP1
TNFAIP3 interacting protein 1
chr17_-_38978824 0.609 NM_000421
KRT10
keratin 10
chr1_+_209878135 0.608 NM_005525
HSD11B1
hydroxysteroid (11-beta) dehydrogenase 1
chr7_+_90032771 0.607 CLDN12
claudin 12
chr4_-_99851785 0.606 NM_001130679
NM_001968
EIF4E

eukaryotic translation initiation factor 4E

chr2_-_135782246 0.606 NM_001018046
NM_025052
YSK4

YSK4 Sps1/Ste20-related kinase homolog (S. cerevisiae)

chr13_+_109281569 0.606 NM_001198950
MYO16
myosin XVI
chr8_+_57358361 0.605


chr9_-_19786886 0.604 NM_001193288
NM_020344
SLC24A2

solute carrier family 24 (sodium/potassium/calcium exchanger), member 2

chr19_+_41725259 0.603 AXL
AXL receptor tyrosine kinase
chr13_-_43566301 0.601 NM_001002264
NM_033255
EPSTI1

epithelial stromal interaction 1 (breast)

chr15_-_99789585 0.594 NM_001040655
NM_001040656
NM_001040657
NM_001040658
NM_001040659
NM_001040660
NM_022905
TTC23






tetratricopeptide repeat domain 23






chr3_+_130569368 0.592 NM_001199180
NM_001199181
NM_001199182
ATP2C1


ATPase, Ca++ transporting, type 2C, member 1


chr13_+_52436116 0.592 NM_031290
CCDC70
coiled-coil domain containing 70
chr2_+_67624431 0.591 NM_019002
ETAA1
Ewing tumor-associated antigen 1
chr18_+_61554938 0.591 NM_001143818
NM_002575
SERPINB2

serpin peptidase inhibitor, clade B (ovalbumin), member 2


Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.45 1.22e-02 GO:0006955 immune response

Nothing significant found in compartment category.

Nothing significant found in function category.