Motif ID: HMX1.p2

Z-value: 1.422


Transcription factors associated with HMX1.p2:

Gene SymbolEntrez IDGene Name
HMX1 3166 H6 family homeobox 1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.p-valuePlot
HMX1chr4_-_8873453-0.367.3e-02Click!


Activity profile for motif HMX1.p2.

activity profile for motif HMX1.p2


Sorted Z-values histogram for motif HMX1.p2

Sorted Z-values for motif HMX1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of HMX1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr14_-_105634708 6.500 JAG2
jagged 2
chr5_-_81046858 4.264 SSBP2
single-stranded DNA binding protein 2
chr1_+_25943958 4.209 NM_020379
MAN1C1
mannosidase, alpha, class 1C, member 1
chr5_+_68788387 4.100 NM_001205254
OCLN
occludin
chr12_+_53440809 3.653 NM_198316
TENC1
tensin like C1 domain containing phosphatase (tensin 2)
chr3_-_18466759 3.425 NM_001195470
NM_002971
SATB1

SATB homeobox 1

chr1_+_221053000 3.396 HLX
H2.0-like homeobox
chr1_-_59042827 3.332 TACSTD2
tumor-associated calcium signal transducer 2
chr5_-_81046943 3.305 NM_012446
SSBP2
single-stranded DNA binding protein 2
chr6_-_13486986 3.110 GFOD1
glucose-fructose oxidoreductase domain containing 1
chr14_-_105635114 3.079 NM_002226
NM_145159
JAG2

jagged 2

chr11_-_33890931 2.971 LMO2
LIM domain only 2 (rhombotin-like 1)
chr1_+_221052845 2.930 HLX
H2.0-like homeobox
chr2_-_220436267 2.856 NM_001173408
NM_001173431
NM_015311
OBSL1


obscurin-like 1


chr11_-_33891258 2.854 LMO2
LIM domain only 2 (rhombotin-like 1)
chr2_+_203499819 2.691 NM_173511
FAM117B
family with sequence similarity 117, member B
chr13_+_58207858 2.473 PCDH17
protocadherin 17
chr4_-_186733372 2.302 NM_003603
NM_001145670
SORBS2

sorbin and SH3 domain containing 2

chr6_-_130031278 2.283 NM_033515
ARHGAP18
Rho GTPase activating protein 18
chr8_-_24772229 2.282 NEFM
neurofilament, medium polypeptide
chr3_-_15900928 2.265 NM_015199
ANKRD28
ankyrin repeat domain 28
chr18_+_72998258 2.243 TSHZ1
teashirt zinc finger homeobox 1
chr8_+_37654833 2.243 GPR124
G protein-coupled receptor 124
chr6_-_41909386 2.234 NM_001136125
NM_001760
CCND3

cyclin D3

chr11_-_19262424 2.122 NM_024680
E2F8
E2F transcription factor 8
chr1_-_92351613 2.120 NM_001195683
NM_003243
TGFBR3

transforming growth factor, beta receptor III

chr1_+_82266081 2.112 NM_012302
LPHN2
latrophilin 2
chr2_+_112656200 2.040 MERTK
c-mer proto-oncogene tyrosine kinase
chr2_+_112656180 1.973 NM_006343
MERTK
c-mer proto-oncogene tyrosine kinase
chr18_-_45935627 1.970 ZBTB7C
zinc finger and BTB domain containing 7C
chr1_-_27286875 1.960 NM_152365
C1orf172
chromosome 1 open reading frame 172
chr1_-_33168356 1.947 NM_001161708
NM_030786
SYNC

syncoilin, intermediate filament protein

chr12_+_57482674 1.938 NM_005967
NAB2
NGFI-A binding protein 2 (EGR1 binding protein 2)
chr6_+_16238780 1.928 NM_006877
GMPR
guanosine monophosphate reductase
chr7_-_132261268 1.893 NM_001105543
NM_020911
PLXNA4

plexin A4

chr7_+_22766765 1.847 NM_000600
IL6
interleukin 6 (interferon, beta 2)
chr11_+_59522905 1.824 STX3
syntaxin 3
chr8_+_120220554 1.772 NM_052886
MAL2
mal, T-cell differentiation protein 2 (gene/pseudogene)
chr2_-_220436010 1.749 OBSL1
obscurin-like 1
chr18_+_11981421 1.734 NM_014214
IMPA2
inositol(myo)-1(or 4)-monophosphatase 2
chr14_+_63671101 1.699 NM_020663
RHOJ
ras homolog gene family, member J
chr4_+_156587861 1.691 NM_000856
NM_001130682
NM_001130686
NM_001130687
NM_001130683
NM_001130685
GUCY1A3





guanylate cyclase 1, soluble, alpha 3





chr8_-_93115453 1.681 NM_001198633
NM_175634
RUNX1T1

runt-related transcription factor 1; translocated to, 1 (cyclin D-related)

chr12_+_82752275 1.678 NM_032230
C12orf26
chromosome 12 open reading frame 26
chr12_+_57482922 1.664 NAB2
NGFI-A binding protein 2 (EGR1 binding protein 2)
chr8_+_144816287 1.664 LOC100128338
uncharacterized LOC100128338
chr9_-_130616592 1.664 ENG
endoglin
chr12_-_96184346 1.661 NTN4
netrin 4
chr1_+_25944610 1.650 MAN1C1
mannosidase, alpha, class 1C, member 1
chr12_-_59313304 1.628 NM_001136051
LRIG3
leucine-rich repeats and immunoglobulin-like domains 3
chr2_-_165478357 1.605 NM_004490
GRB14
growth factor receptor-bound protein 14
chr19_+_1026608 1.586 CNN2
calponin 2
chr21_-_40032563 1.583 NM_001243428
ERG
v-ets erythroblastosis virus E26 oncogene homolog (avian)
chr18_-_500583 1.561 NM_130386
COLEC12
collectin sub-family member 12
chr12_+_57482886 1.537 NAB2
NGFI-A binding protein 2 (EGR1 binding protein 2)
chr5_+_139027907 1.536 CXXC5
CXXC finger protein 5
chr7_-_21985421 1.533 NM_001127370
NM_001127371
NM_018719
CDCA7L


cell division cycle associated 7-like


chr10_+_99258615 1.531 NM_024954
UBTD1
ubiquitin domain containing 1
chr20_-_33735060 1.526 NM_001145025
NM_018217
EDEM2

ER degradation enhancer, mannosidase alpha-like 2

chr6_-_2245655 1.524 NM_001500
GMDS
GDP-mannose 4,6-dehydratase
chr9_-_130616760 1.521 ENG
endoglin
chr18_+_11981552 1.508 IMPA2
inositol(myo)-1(or 4)-monophosphatase 2
chr20_-_33734894 1.507 EDEM2
ER degradation enhancer, mannosidase alpha-like 2
chr12_-_29936685 1.482 NM_001193451
TMTC1
transmembrane and tetratricopeptide repeat containing 1
chr5_+_68710938 1.474 NM_001038603
NM_001244734
MARVELD2

MARVEL domain containing 2

chr9_-_130617009 1.465 NM_000118
NM_001114753
ENG

endoglin

chr6_-_13486382 1.451 NM_001242628
GFOD1
glucose-fructose oxidoreductase domain containing 1
chr2_-_191878883 1.442 STAT1
signal transducer and activator of transcription 1, 91kDa
chr19_+_38755097 1.409 NM_001166103
NM_021102
SPINT2

serine peptidase inhibitor, Kunitz type, 2

chr17_+_5973640 1.409 NM_015253
WSCD1
WSC domain containing 1
chr1_+_156863522 1.396 NM_001080471
PEAR1
platelet endothelial aggregation receptor 1
chr15_+_75639330 1.394 NM_024608
NEIL1
nei endonuclease VIII-like 1 (E. coli)
chr9_-_130616957 1.389 ENG
endoglin
chr21_-_44845920 1.385 SIK1
salt-inducible kinase 1
chr11_+_7535000 1.380 NM_003621
PPFIBP2
PTPRF interacting protein, binding protein 2 (liprin beta 2)
chr17_-_7166263 1.378 NM_001185023
NM_001307
CLDN7

claudin 7

chr11_+_59522801 1.377 STX3
syntaxin 3
chr9_+_22447064 1.375


chr2_-_191878908 1.366 STAT1
signal transducer and activator of transcription 1, 91kDa
chr2_-_191878882 1.359 STAT1
signal transducer and activator of transcription 1, 91kDa
chr6_+_86159738 1.359 NT5E
5'-nucleotidase, ecto (CD73)
chr7_+_22767101 1.356 IL6
interleukin 6 (interferon, beta 2)
chr4_+_42399855 1.345 NM_001080505
SHISA3
shisa homolog 3 (Xenopus laevis)
chr9_+_115513050 1.345 NM_001012994
SNX30
sorting nexin family member 30
chr7_-_752742 1.335 NM_001164761
PRKAR1B
protein kinase, cAMP-dependent, regulatory, type I, beta
chr19_-_14316980 1.333 NM_001008701
NM_014921
LPHN1

latrophilin 1

chr2_+_61293038 1.332 KIAA1841
KIAA1841
chr19_+_38755238 1.330 SPINT2
serine peptidase inhibitor, Kunitz type, 2
chr2_-_191878924 1.329 NM_007315
NM_139266
STAT1

signal transducer and activator of transcription 1, 91kDa

chr5_+_139027868 1.326 CXXC5
CXXC finger protein 5
chr22_+_50781717 1.318 NM_001242898
NM_001242899
NM_001242900
NM_014678
PPP6R2



protein phosphatase 6, regulatory subunit 2



chr2_-_69870705 1.317 AAK1
AP2 associated kinase 1
chr5_-_88179278 1.305 NM_001193350
NM_002397
MEF2C

myocyte enhancer factor 2C

chr7_+_12726413 1.303 NM_001037164
NM_212460
ARL4A

ADP-ribosylation factor-like 4A

chr2_-_129076045 1.296 NM_004807
HS6ST1
heparan sulfate 6-O-sulfotransferase 1
chr2_+_61292999 1.296 NM_001129993
KIAA1841
KIAA1841
chr9_+_137967401 1.289 OLFM1
olfactomedin 1
chr7_+_12726910 1.280 NM_001195396
NM_005738
ARL4A

ADP-ribosylation factor-like 4A

chr6_+_2765561 1.279 WRNIP1
Werner helicase interacting protein 1
chr17_-_62097937 1.276 NM_001099786
NM_001099787
NM_001099788
NM_001099789
ICAM2



intercellular adhesion molecule 2



chr19_+_38755422 1.275 SPINT2
serine peptidase inhibitor, Kunitz type, 2
chr6_+_34857021 1.274 NM_015245
ANKS1A
ankyrin repeat and sterile alpha motif domain containing 1A
chr5_-_88119604 1.273 NM_001193348
NM_001193349
MEF2C

myocyte enhancer factor 2C

chr4_-_90758126 1.271 NM_001146054
NM_007308
NM_000345
SNCA


synuclein, alpha (non A4 component of amyloid precursor)


chr9_-_10612722 1.259 NM_002839
PTPRD
protein tyrosine phosphatase, receptor type, D
chr9_-_125941304 1.248 STRBP
spermatid perinuclear RNA binding protein
chr22_+_51113069 1.239 NM_001080420
SHANK3
SH3 and multiple ankyrin repeat domains 3
chr12_-_96184510 1.233 NM_021229
NTN4
netrin 4
chr2_-_165477818 1.219 GRB14
growth factor receptor-bound protein 14
chrX_-_70473941 1.219 ZMYM3
zinc finger, MYM-type 3
chr3_+_49711751 1.218 APEH
N-acylaminoacyl-peptide hydrolase
chr1_+_150337145 1.215 RPRD2
regulation of nuclear pre-mRNA domain containing 2
chr12_+_51318743 1.212 METTL7A
methyltransferase like 7A
chr12_+_27397077 1.203 NM_015000
STK38L
serine/threonine kinase 38 like
chr10_+_8097350 1.203 GATA3
GATA binding protein 3
chr13_+_42031679 1.198 C13orf15
chromosome 13 open reading frame 15
chr13_+_42031690 1.197 C13orf15
chromosome 13 open reading frame 15
chr1_+_78511588 1.184 NM_017655
GIPC2
GIPC PDZ domain containing family, member 2
chr13_+_42031525 1.170 NM_014059
C13orf15
chromosome 13 open reading frame 15
chr2_-_27712520 1.162 NM_015662
IFT172
intraflagellar transport 172 homolog (Chlamydomonas)
chr8_-_28243941 1.161 NM_018660
ZNF395
zinc finger protein 395
chr1_-_35920081 1.154 KIAA0319L
KIAA0319-like
chr16_-_86542463 1.141 LOC400550
uncharacterized LOC400550
chr8_-_29120571 1.140 NM_015254
KIF13B
kinesin family member 13B
chr19_+_1026627 1.134 CNN2
calponin 2
chr11_-_61129462 1.134 NM_001161454
NM_153611
CYBASC3

cytochrome b, ascorbate dependent 3

chr7_+_30951414 1.131 NM_198098
AQP1
aquaporin 1 (Colton blood group)
chr1_+_150336584 1.120 RPRD2
regulation of nuclear pre-mRNA domain containing 2
chr5_+_139027955 1.117 CXXC5
CXXC finger protein 5
chr22_+_29702950 1.089 NM_006478
NM_152236
NM_152237
GAS2L1


growth arrest-specific 2 like 1


chr2_-_165477986 1.088 GRB14
growth factor receptor-bound protein 14
chr4_-_102267952 1.085 PPP3CA
protein phosphatase 3, catalytic subunit, alpha isozyme
chr19_+_50796820 1.084 MYH14
myosin, heavy chain 14, non-muscle
chr6_-_7910716 1.078 NM_030810
TXNDC5
thioredoxin domain containing 5 (endoplasmic reticulum)
chrX_+_101967290 1.077 GPRASP2
G protein-coupled receptor associated sorting protein 2
chr17_-_8534008 1.077 NM_005964
MYH10
myosin, heavy chain 10, non-muscle
chr3_-_125775609 1.072 NM_001008487
SLC41A3
solute carrier family 41, member 3
chr12_+_3068442 1.061 NM_003213
NM_201441
NM_201443
TEAD4


TEA domain family member 4


chr11_-_116968986 1.052 NM_025164
SIK3
SIK family kinase 3
chr11_+_7618416 1.049 PPFIBP2
PTPRF interacting protein, binding protein 2 (liprin beta 2)
chr17_-_34313685 1.046 NM_032962
NM_032963
CCL14

chemokine (C-C motif) ligand 14

chr11_+_68079999 1.045 NM_002335
LRP5
low density lipoprotein receptor-related protein 5
chr4_-_114682836 1.042 NM_001221
NM_172114
NM_172115
NM_172127
NM_172128
NM_172129
CAMK2D





calcium/calmodulin-dependent protein kinase II delta





chr19_+_1026271 1.039 NM_004368
NM_201277
CNN2

calponin 2

chr20_-_62601140 1.028 NM_020713
ZNF512B
zinc finger protein 512B
chr6_+_84743250 1.025 NM_138409
MRAP2
melanocortin 2 receptor accessory protein 2
chr17_+_19551835 1.018 NM_000382
NM_001031806
ALDH3A2

aldehyde dehydrogenase 3 family, member A2

chr15_-_90198524 1.007 NM_198525
KIF7
kinesin family member 7
chr4_-_107237794 1.005 NM_001163436
TBCK
TBC1 domain containing kinase
chr20_-_35374530 0.995 NM_022477
NM_032013
NDRG3

NDRG family member 3

chr10_-_33623771 0.991 NM_001024628
NM_001024629
NM_001244972
NM_001244973
NM_003873
NRP1




neuropilin 1




chr19_-_36545119 0.988 THAP8
THAP domain containing 8
chr11_+_66624501 0.987 LRFN4
leucine rich repeat and fibronectin type III domain containing 4
chr6_+_7727010 0.978 NM_001718
BMP6
bone morphogenetic protein 6
chr15_-_82336880 0.976 MEX3B
mex-3 homolog B (C. elegans)
chr22_+_50781773 0.975 PPP6R2
protein phosphatase 6, regulatory subunit 2
chr3_+_57994087 0.972 NM_001164317
NM_001164318
NM_001164319
NM_001457
FLNB



filamin B, beta



chr1_+_145524989 0.971 NM_003637
ITGA10
integrin, alpha 10
chr7_+_130131921 0.963 NM_002402
MEST
mesoderm specific transcript homolog (mouse)
chr20_-_35374468 0.963 NDRG3
NDRG family member 3
chr2_-_192015733 0.960 STAT4
signal transducer and activator of transcription 4
chr3_-_183735617 0.958 NM_001023587
NM_005688
ABCC5

ATP-binding cassette, sub-family C (CFTR/MRP), member 5

chr1_-_24194760 0.956 NM_000147
FUCA1
fucosidase, alpha-L- 1, tissue
chr8_+_143808593 0.955 NM_016647
C8orf55
chromosome 8 open reading frame 55
chr7_-_37488408 0.948 ELMO1
engulfment and cell motility 1
chr7_+_12727204 0.944 ARL4A
ADP-ribosylation factor-like 4A
chr19_-_19006868 0.934 NM_021267
NM_198207
NM_001492
CERS1

GDF1
ceramide synthase 1

growth differentiation factor 1
chr12_-_42877785 0.932 NM_001144882
NM_001144883
PRICKLE1

prickle homolog 1 (Drosophila)

chr16_+_68119211 0.925 NM_004555
NM_173163
NM_173165
NFATC3


nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3


chr1_+_64058891 0.915 NM_002633
PGM1
phosphoglucomutase 1
chr4_-_110650965 0.911 NM_030821
PLA2G12A
phospholipase A2, group XIIA
chr15_+_83776323 0.902 NM_001144903
NM_023003
TM6SF1

transmembrane 6 superfamily member 1

chr2_-_192015751 0.897 STAT4
signal transducer and activator of transcription 4
chr9_+_131644427 0.893 LRRC8A
leucine rich repeat containing 8 family, member A
chr7_-_37488554 0.886 NM_014800
ELMO1
engulfment and cell motility 1
chr19_+_18530087 0.880 NM_001009998
NM_032627
SSBP4

single stranded DNA binding protein 4

chr17_-_7165788 0.876 CLDN7
claudin 7
chr3_+_50192420 0.876 SEMA3F
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F
chr22_+_19744225 0.872 NM_005992
NM_080646
NM_080647
TBX1


T-box 1


chr4_+_156588811 0.868 NM_001130684
GUCY1A3
guanylate cyclase 1, soluble, alpha 3
chr1_-_225615701 0.867 LBR
lamin B receptor
chrX_-_153718937 0.850 SLC10A3
solute carrier family 10 (sodium/bile acid cotransporter family), member 3
chr9_+_131644368 0.843 NM_001127245
NM_019594
LRRC8A

leucine rich repeat containing 8 family, member A

chrX_-_70473979 0.842 NM_201599
ZMYM3
zinc finger, MYM-type 3
chr2_-_192015706 0.841 STAT4
signal transducer and activator of transcription 4
chr2_-_192015934 0.835 NM_003151
STAT4
signal transducer and activator of transcription 4
chr9_-_85677784 0.829 RASEF
RAS and EF-hand domain containing
chr8_-_28347733 0.829 NM_172366
FBXO16
ZNF395
F-box protein 16
zinc finger protein 395
chr11_+_66624875 0.822 NM_024036
LRFN4
leucine rich repeat and fibronectin type III domain containing 4
chr15_-_102029872 0.819 PCSK6
proprotein convertase subtilisin/kexin type 6
chr10_-_52383611 0.818 NM_147156
SGMS1
sphingomyelin synthase 1
chrX_+_150863729 0.816 NM_024082
PRRG3
proline rich Gla (G-carboxyglutamic acid) 3 (transmembrane)
chr15_-_56035176 0.813 NM_173814
PRTG
protogenin
chrX_-_70474402 0.810 NM_001171163
NM_005096
ZMYM3

zinc finger, MYM-type 3

chr1_+_92495484 0.810 NM_173567
EPHX4
epoxide hydrolase 4
chr1_+_26856259 0.810 RPS6KA1
ribosomal protein S6 kinase, 90kDa, polypeptide 1
chr8_-_28243589 0.802 ZNF395
zinc finger protein 395
chr6_-_8102753 0.801 NM_001135650
NM_004280
EEF1E1

eukaryotic translation elongation factor 1 epsilon 1

chrX_-_153718984 0.799 NM_001142391
NM_001142392
NM_019848
SLC10A3


solute carrier family 10 (sodium/bile acid cotransporter family), member 3


chr11_-_119252267 0.799 USP2
ubiquitin specific peptidase 2

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.09 3.49e-03 GO:0009987 cellular process
1.41 1.36e-02 GO:0009966 regulation of signal transduction
1.37 2.04e-02 GO:0023051 regulation of signaling
1.34 2.13e-02 GO:0048583 regulation of response to stimulus
1.15 3.22e-02 GO:0044237 cellular metabolic process
2.05 3.65e-02 GO:0048011 nerve growth factor receptor signaling pathway

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.29 1.72e-02 GO:0005829 cytosol
1.07 3.69e-02 GO:0005622 intracellular
1.10 4.10e-02 GO:0005737 cytoplasm

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.08 2.17e-03 GO:0005488 binding
1.13 1.40e-02 GO:0005515 protein binding
1.51 2.59e-02 GO:0016773 phosphotransferase activity, alcohol group as acceptor