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Motif ID: IRF1,2,7.p3

Z-value: 10.966

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Top targets:

Promoter	Score	Refseq	Gene Symbol	Gene Name
chr1_+_79086087	162.424	NM_006820	IFI44L	interferon-induced protein 44-like
chr10_+_91087601	119.038	NM_001549	IFIT3	interferon-induced protein with tetratricopeptide repeats 3
chr12_+_113376001	118.809		OAS3	2'-5'-oligoadenylate synthetase 3, 100kDa
chr10_+_91152321	118.540	NM_001548	IFIT1	interferon-induced protein with tetratricopeptide repeats 1
chr10_+_91092238	117.946	NM_001031683	IFIT3	interferon-induced protein with tetratricopeptide repeats 3
chr6_-_29527701	115.439	NM_006398	UBD	ubiquitin D
chr2_-_7005764	113.141	NM_207315	CMPK2	cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial
chr6_-_29527477	111.327		UBD	ubiquitin D
chr4_-_76944585	106.843	NM_001565	CXCL10	chemokine (C-X-C motif) ligand 10
chr21_+_42792441	101.777	NM_001144925	MX1	myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)
chr12_+_113376301	95.813		OAS3	2'-5'-oligoadenylate synthetase 3, 100kDa
chr16_-_67970651	92.098		PSMB10	proteasome (prosome, macropain) subunit, beta type, 10
chr17_-_40264687	88.325	NM_024119	DHX58	DEXH (Asp-Glu-X-His) box polypeptide 58
chr16_-_67970734	80.337	NM_002801	PSMB10	proteasome (prosome, macropain) subunit, beta type, 10
chr12_+_113416267	78.756	NM_001032731 NM_002535 NM_016817	OAS2	2'-5'-oligoadenylate synthetase 2, 69/71kDa
chr22_+_18632841	78.101		USP18	ubiquitin specific peptidase 18
chr22_+_18632704	76.713	NM_017414	USP18	ubiquitin specific peptidase 18
chr6_+_32821924	73.342	NM_002800	PSMB9	proteasome (prosome, macropain) subunit, beta type, 9 (large multifunctional peptidase 2)
chr13_-_43566301	70.549	NM_001002264 NM_033255	EPSTI1	epithelial stromal interaction 1 (breast)
chr12_+_113376226	67.224	NM_006187	OAS3	2'-5'-oligoadenylate synthetase 3, 100kDa
chr6_-_32821412	63.788		TAP1	transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
chr6_-_32821592	63.172		TAP1	transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
chr4_+_89300110	61.857		HERC6	hect domain and RLD 6
chr6_-_32821743	61.490	NM_000593	TAP1	transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
chr9_+_5510544	61.065	NM_025239	PDCD1LG2	programmed cell death 1 ligand 2
chr6_+_26440699	60.676	NM_001242803 NM_006994 NM_197974	BTN3A3	butyrophilin, subfamily 3, member A3
chr4_-_169239816	59.432	NM_017631	DDX60	DEAD (Asp-Glu-Ala-Asp) box polypeptide 60
chr3_+_122399665	57.309	NM_017554	PARP14	poly (ADP-ribose) polymerase family, member 14
chr1_-_149908759	55.487	NM_001145862	MTMR11	myotubularin related protein 11
chr11_-_615920	55.231		IRF7	interferon regulatory factor 7
chr4_+_142557722	55.100	NM_000585 NM_172175	IL15	interleukin 15
chr17_+_6659155	54.646	NM_017523 NM_199139	XAF1	XIAP associated factor 1
chr11_-_615998	53.548	NM_001572 NM_004029	IRF7	interferon regulatory factor 7
chr1_+_948846	52.589	NM_005101	ISG15	ISG15 ubiquitin-like modifier
chr19_+_18284578	49.119	NM_006332	IFI30	interferon, gamma-inducible protein 30
chr1_-_149908721	48.858		MTMR11	myotubularin related protein 11
chr11_-_60719116	48.651	NM_016582	SLC15A3	solute carrier family 15, member 3
chr15_+_89182038	48.409	NM_002201	ISG20	interferon stimulated exonuclease gene 20kDa
chr21_+_42733916	47.296	NM_002463	LOC100131190 MX2	uncharacterized LOC100131190 myxovirus (influenza virus) resistance 2 (mouse)
chr22_+_36044412	46.461	NM_030641	APOL6	apolipoprotein L, 6
chr11_-_4414887	46.083	NM_003141	TRIM21	tripartite motif containing 21
chr2_+_7017795	45.874	NM_080657	RSAD2	radical S-adenosyl methionine domain containing 2
chr7_-_92777657	45.528	NM_152703	SAMD9L	sterile alpha motif domain containing 9-like
chr1_-_89488412	44.971	NM_018284	GBP3	guanylate binding protein 3
chr5_+_131746579	44.343		C5orf56	chromosome 5 open reading frame 56
chr1_+_79115476	42.731	NM_006417	IFI44	interferon-induced protein 44
chr19_+_18284619	41.913		IFI30	interferon, gamma-inducible protein 30
chr6_+_26402464	41.219	NM_001145008 NM_001145009 NM_007048 NM_194441	BTN3A1	butyrophilin, subfamily 3, member A1
chr1_-_89530890	40.675	NM_002053	GBP1	guanylate binding protein 1, interferon-inducible
chr3_-_122283423	40.633	NM_001146103 NM_031458	PARP9	poly (ADP-ribose) polymerase family, member 9
chr17_+_25958257	40.424		LGALS9	lectin, galactoside-binding, soluble, 9
chr17_+_25958245	40.307		LGALS9	lectin, galactoside-binding, soluble, 9
chr11_+_71710662	39.547	NM_001145057	IL18BP	interleukin 18 binding protein
chr17_+_6659356	39.176		XAF1	XIAP associated factor 1
chr9_-_32526164	39.144	NM_014314	DDX58	DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
chr21_+_42797977	39.040	NM_002462 NM_001178046	MX1	myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)
chr17_-_20370819	38.965	NM_001042685	LGALS9B	lectin, galactoside-binding, soluble, 9B
chr11_+_69455837	38.058	NM_053056	CCND1	cyclin D1
chr3_+_122283139	37.160	NM_138287	DTX3L	deltex 3-like (Drosophila)
chr19_-_50400131	36.550	NM_152899	IL4I1	interleukin 4 induced 1
chr22_-_36556781	36.192	NM_145640	APOL3	apolipoprotein L, 3
chr11_-_57335080	35.719	NM_004223	UBE2L6	ubiquitin-conjugating enzyme E2L 6
chr6_-_32806545	35.517	NM_000544 NM_018833	TAP2	transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)
chr3_-_123339178	35.495		MYLK	myosin light chain kinase
chr3_-_122283077	34.917	NM_001146102 NM_001146105 NM_001146104 NM_001146106	PARP9	poly (ADP-ribose) polymerase family, member 9
chr11_-_615649	33.770	NM_004031	IRF7	interferon regulatory factor 7
chr19_+_10196757	33.260	NM_018381	C19orf66	chromosome 19 open reading frame 66
chr19_+_18284631	33.251		IFI30	interferon, gamma-inducible protein 30
chr19_+_10196972	32.402		C19orf66	chromosome 19 open reading frame 66
chr22_-_36635552	32.380		APOL2	apolipoprotein L, 2
chr17_+_25958217	31.226		LGALS9	lectin, galactoside-binding, soluble, 9
chr12_+_113344811	31.182		OAS1	2'-5'-oligoadenylate synthetase 1, 40/46kDa
chr13_+_50070096	31.055		PHF11	PHD finger protein 11
chr6_-_32806452	30.926		TAP2	transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)
chr17_+_25958151	30.638	NM_002308 NM_009587	LGALS9	lectin, galactoside-binding, soluble, 9
chr3_-_123339423	30.490	NM_053031 NM_053032	MYLK	myosin light chain kinase
chr17_+_25958192	30.384		LGALS9	lectin, galactoside-binding, soluble, 9
chr13_+_50070527	30.331	NM_001040444	PHF11	PHD finger protein 11
chr17_+_18380097	30.065	NM_001040078	LGALS9B LGALS9C	lectin, galactoside-binding, soluble, 9B lectin, galactoside-binding, soluble, 9C
chr15_+_74287132	29.195		PML	promyelocytic leukemia
chr2_-_231084600	29.076	NM_004509 NM_004510 NM_080424	SP110	SP110 nuclear body protein
chr9_-_100881462	28.630	NM_014788 NM_033219 NM_033220	TRIM14	tripartite motif containing 14
chr12_+_102271082	27.383	NM_018370	DRAM1	DNA-damage regulated autophagy modulator 1
chr7_-_139762339	27.351		PARP12	poly (ADP-ribose) polymerase family, member 12
chr3_+_187086167	27.194	NM_022147	RTP4	receptor (chemosensory) transporter protein 4
chr14_+_94577078	27.180	NM_001130080 NM_005532	IFI27	interferon, alpha-inducible protein 27
chr11_+_71710971	27.008	NM_001145055	IL18BP	interleukin 18 binding protein
chr22_+_36649116	26.865	NM_001136540 NM_001136541 NM_003661 NM_145343	APOL1	apolipoprotein L, 1
chr4_+_186990308	26.712	NM_003265	TLR3	toll-like receptor 3
chr11_+_5710816	26.216	NM_001199573 NM_006074	TRIM22	tripartite motif containing 22
chr2_-_152146133	26.051		NMI	N-myc (and STAT) interactor
chr4_-_122148620	25.973	NM_001244764	TNIP3	TNFAIP3 interacting protein 3
chr13_+_50069745	25.917	NM_001040443	PHF11	PHD finger protein 11
chr1_-_27998700	25.777		IFI6	interferon, alpha-inducible protein 6
chr6_+_26365397	25.422	NM_001197247 NM_001197249 NM_007047 NM_001197248	BTN3A2	butyrophilin, subfamily 3, member A2
chr2_-_220252627	25.364	NM_012100	DNPEP	aspartyl aminopeptidase
chr15_+_74287148	25.348		PML	promyelocytic leukemia
chr8_+_54764367	25.163	NM_170587	RGS20	regulator of G-protein signaling 20
chr6_-_32812189	24.678		PSMB8	proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional peptidase 7)
chr2_-_37384026	24.225		EIF2AK2	eukaryotic translation initiation factor 2-alpha kinase 2
chr11_-_104972147	23.276	NM_001007232 NM_001223 NM_033292 NM_033293 NM_033294 NM_033295	CARD17 CASP1	caspase recruitment domain family, member 17 caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)
chr15_+_74287107	22.945		PML	promyelocytic leukemia
chr19_+_10197023	22.704		C19orf66	chromosome 19 open reading frame 66
chr2_-_220252569	22.672		DNPEP	aspartyl aminopeptidase
chr7_+_100728719	22.611	NM_030961	TRIM56	tripartite motif containing 56
chr19_-_47735858	21.913	NM_001127240 NM_001127241 NM_001127242	BBC3	BCL2 binding component 3
chr2_-_152146373	21.876	NM_004688	NMI	N-myc (and STAT) interactor
chr10_+_115439632	21.850		CASP7	caspase 7, apoptosis-related cysteine peptidase
chr10_+_115439425	21.683	NM_001227 NM_033338 NM_033339	CASP7	caspase 7, apoptosis-related cysteine peptidase
chr6_+_116782555	21.374	NM_001010919	FAM26F	family with sequence similarity 26, member F
chr22_+_36649172	21.163		APOL1	apolipoprotein L, 1
chr6_-_32811773	20.779	NM_148919	PSMB8	proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional peptidase 7)
chr6_+_126240369	20.703	NM_001199622	NCOA7	nuclear receptor coactivator 7
chr10_-_6019454	20.583	NM_002189 NM_172200	IL15RA	interleukin 15 receptor, alpha
chr5_+_96212167	20.135		ERAP2	endoplasmic reticulum aminopeptidase 2
chr8_-_23540401	20.034	NM_006167	NKX3-1	NK3 homeobox 1
chr2_-_231989755	20.030	NM_000867	HTR2B	5-hydroxytryptamine (serotonin) receptor 2B
chr10_+_91174303	19.442	NM_012420	IFIT5	interferon-induced protein with tetratricopeptide repeats 5
chr22_+_39473009	19.399	NM_021822	APOBEC3G	apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G
chr1_+_110453232	19.146	NM_000757 NM_172210 NM_172212	CSF1	colony stimulating factor 1 (macrophage)
chr7_-_92747317	19.126	NM_001193307 NM_017654	SAMD9	sterile alpha motif domain containing 9
chr10_+_91061705	18.997	NM_001547	IFIT2	interferon-induced protein with tetratricopeptide repeats 2
chr12_+_78225068	18.672	NM_014903	NAV3	neuron navigator 3
chr9_+_100174179	18.500	NM_014290	TDRD7	tudor domain containing 7
chr1_+_110453456	18.037		CSF1	colony stimulating factor 1 (macrophage)
chr1_-_27998719	17.865	NM_002038 NM_022872 NM_022873	IFI6	interferon, alpha-inducible protein 6
chr2_+_231280906	17.662		SP100	SP100 nuclear antigen
chr2_-_220252513	17.385		DNPEP	aspartyl aminopeptidase
chr7_-_77045706	17.325	NM_017439	PION	pigeon homolog (Drosophila)
chr15_+_74286999	17.008	NM_002675 NM_033238 NM_033239 NM_033240 NM_033244 NM_033246 NM_033247 NM_033249 NM_033250	PML	promyelocytic leukemia
chr7_-_92747269	16.749		SAMD9	sterile alpha motif domain containing 9
chr1_-_154580481	15.985		ADAR	adenosine deaminase, RNA-specific
chr11_-_102668822	15.843		MMP1	matrix metallopeptidase 1 (interstitial collagenase)
chr13_-_44203608	15.829	NM_001127615	ENOX1	ecto-NOX disulfide-thiol exchanger 1
chr20_+_61436160	15.826	NM_007346	OGFR	opioid growth factor receptor
chr10_-_6019880	15.726	NM_001243539	IL15RA	interleukin 15 receptor, alpha
chr1_-_154580632	15.655		ADAR	adenosine deaminase, RNA-specific
chr2_+_75061234	15.541		HK2	hexokinase 2
chr17_+_78237389	15.423
chr20_+_388941	15.353		RBCK1	RanBP-type and C3HC4-type zinc finger containing 1
chr22_-_36635666	15.189	NM_030882	APOL2	apolipoprotein L, 2
chr20_+_388717	15.030		RBCK1	RanBP-type and C3HC4-type zinc finger containing 1
chr6_-_101329006	15.027		ASCC3	activating signal cointegrator 1 complex subunit 3
chr1_-_27998658	15.018		IFI6	interferon, alpha-inducible protein 6
chr2_-_163174816	14.759	NM_022168	IFIH1	interferon induced with helicase C domain 1
chr1_-_154580677	14.713	NM_001111 NM_015840 NM_015841	ADAR	adenosine deaminase, RNA-specific
chr17_+_41363845	14.663	NM_145041	TMEM106A	transmembrane protein 106A
chr22_-_36562224	14.647	NM_145641 NM_145642	APOL3	apolipoprotein L, 3
chr11_+_93862143	14.634		PANX1	pannexin 1
chr2_+_231280933	14.388		SP100	SP100 nuclear antigen
chr16_+_56659584	14.314	NM_175617	MT1E	metallothionein 1E
chr11_+_93862060	14.228	NM_015368	PANX1	pannexin 1
chr16_+_56659679	14.122		MT1E	metallothionein 1E
chr15_+_71184781	14.001	NM_001199017 NM_017691 NM_001199018	LRRC49	leucine rich repeat containing 49
chrX_+_38211735	13.830	NM_000531	OTC	ornithine carbamoyltransferase
chr2_+_231280870	13.700	NM_001080391 NM_001206701 NM_001206702 NM_001206703 NM_003113	SP100	SP100 nuclear antigen
chr6_+_31913852	13.591		CFB	complement factor B
chr12_+_6561176	13.579	NM_018009	TAPBPL	TAP binding protein-like
chr6_-_33282006	13.571	NM_003190 NM_172208 NM_172209	TAPBP	TAP binding protein (tapasin)
chr6_-_31239489	13.471		HLA-B HLA-C	major histocompatibility complex, class I, B major histocompatibility complex, class I, C
chr2_+_231191877	13.466	NM_138402	SP140L	SP140 nuclear body protein-like
chr17_-_34207308	13.455	NM_002985	CCL5	chemokine (C-C motif) ligand 5
chr21_+_43933983	13.454		SLC37A1	solute carrier family 37 (glycerol-3-phosphate transporter), member 1
chr6_-_30655671	13.451	NM_133471	PPP1R18	protein phosphatase 1, regulatory subunit 18
chr1_+_120254418	13.333	NM_006623	PHGDH	phosphoglycerate dehydrogenase
chr21_+_45139169	13.210		PDXK	pyridoxal (pyridoxine, vitamin B6) kinase
chr5_-_96143689	13.166	NM_001040458 NM_016442	ERAP1	endoplasmic reticulum aminopeptidase 1
chr4_-_169401603	13.120	NM_001012967	DDX60L	DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like
chr21_+_43619798	12.903	NM_207627 NM_207628	ABCG1	ATP-binding cassette, sub-family G (WHITE), member 1
chr8_-_145060594	12.889	NM_032789	PARP10	poly (ADP-ribose) polymerase family, member 10
chr1_-_203055376	12.696	NM_002479	MYOG	myogenin (myogenic factor 4)
chr9_+_100174369	12.499		TDRD7	tudor domain containing 7
chr21_+_45138987	12.455		PDXK	pyridoxal (pyridoxine, vitamin B6) kinase
chr18_-_6414900	12.296	NM_173464	L3MBTL4	l(3)mbt-like 4 (Drosophila)
chr17_+_41158741	12.259	NM_005533	IFI35	interferon-induced protein 35
chr6_-_30181197	12.257	NM_001242783 NM_003449	TRIM26	tripartite motif containing 26
chr6_-_30181113	12.061		TRIM26	tripartite motif containing 26
chr11_-_57335756	12.060	NM_198183	UBE2L6	ubiquitin-conjugating enzyme E2L 6
chr11_-_64764388	12.048	NM_138456	BATF2	basic leucine zipper transcription factor, ATF-like 2
chr1_-_170038055	11.791	NM_001204517	KIFAP3	kinesin-associated protein 3
chr20_+_44746948	11.652		CD40	CD40 molecule, TNF receptor superfamily member 5
chr6_+_31913763	11.543		CFB	complement factor B
chr21_+_45139018	11.421
chr17_+_78234626	11.372	NM_020914 NM_020954	RNF213	ring finger protein 213
chr3_+_48507621	11.188		TREX1	three prime repair exonuclease 1
chr16_+_29831714	11.183	NM_005115 NM_017458	MVP	major vault protein
chr14_+_58711457	11.171	NM_002788 NM_152132	PSMA3	proteasome (prosome, macropain) subunit, alpha type, 3
chr22_-_36635999	11.091	NM_145637	APOL2	apolipoprotein L, 2
chr6_-_33281847	11.052		TAPBP	TAP binding protein (tapasin)
chr6_+_31913708	10.920	NM_001710	CFB	complement factor B
chr20_+_825284	10.911	NM_031424	FAM110A	family with sequence similarity 110, member A
chr19_-_49371710	10.820	NM_001161354 NM_020904	PLEKHA4	pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4
chr14_+_32798478	10.520	NM_004274	AKAP6	A kinase (PRKA) anchor protein 6
chr3_+_48507209	10.489	NM_016381 NM_033629	TREX1	three prime repair exonuclease 1
chr3_+_11178778	10.477	NM_001098213	HRH1	histamine receptor H1
chr14_+_58711555	10.406		PSMA3	proteasome (prosome, macropain) subunit, alpha type, 3
chr2_-_224810041	10.372	NM_020830	WDFY1	WD repeat and FYVE domain containing 1
chr14_+_58711599	10.285		PSMA3	proteasome (prosome, macropain) subunit, alpha type, 3
chr20_-_47894570	10.147		ZNFX1	zinc finger, NFX1-type containing 1
chr6_-_154831652	10.133		CNKSR3	CNKSR family member 3

Gene overrepresentation in process category:

enrichment	p-value	GO term	description
2.64	3.80e-16	GO:0006955	immune response
2.18	3.82e-15	GO:0002376	immune system process
3.30	5.51e-14	GO:0045087	innate immune response
2.43	1.22e-13	GO:0006952	defense response
7.41	1.84e-13	GO:0034340	response to type I interferon
7.24	1.40e-12	GO:0060337	type I interferon-mediated signaling pathway
7.24	1.40e-12	GO:0071357	cellular response to type I interferon
2.22	4.97e-11	GO:0051704	multi-organism process
3.00	2.26e-10	GO:0044419	interspecies interaction between organisms
4.11	1.06e-09	GO:0009615	response to virus
3.61	1.46e-08	GO:0019221	cytokine-mediated signaling pathway
3.43	2.04e-08	GO:0071345	cellular response to cytokine stimulus
2.98	2.88e-08	GO:0034097	response to cytokine stimulus
2.37	2.47e-05	GO:0051707	response to other organism
2.18	6.30e-05	GO:0009607	response to biotic stimulus
11.04	2.01e-04	GO:0002474	antigen processing and presentation of peptide antigen via MHC class I
1.45	2.03e-04	GO:0006950	response to stress
2.45	2.16e-04	GO:0031347	regulation of defense response
15.38	4.41e-04	GO:0019883	antigen processing and presentation of endogenous antigen
2.06	7.51e-04	GO:0080134	regulation of response to stress
8.08	1.06e-03	GO:0048002	antigen processing and presentation of peptide antigen
1.19	1.08e-03	GO:0050789	regulation of biological process
17.95	1.20e-03	GO:0002483	antigen processing and presentation of endogenous peptide antigen
17.95	1.20e-03	GO:0019885	antigen processing and presentation of endogenous peptide antigen via MHC class I
1.85	2.37e-03	GO:0002682	regulation of immune system process
1.88	3.07e-03	GO:0071310	cellular response to organic substance
1.19	3.38e-03	GO:0050794	regulation of cellular process
1.56	6.56e-03	GO:0033036	macromolecule localization
1.16	9.35e-03	GO:0065007	biological regulation
1.20	1.01e-02	GO:0050896	response to stimulus
3.64	1.30e-02	GO:0043900	regulation of multi-organism process
4.49	1.99e-02	GO:0032479	regulation of type I interferon production
2.69	4.63e-02	GO:0002697	regulation of immune effector process
1.61	4.81e-02	GO:0070887	cellular response to chemical stimulus

Gene overrepresentation in compartment category:

enrichment	p-value	GO term	description
6.28	2.09e-02	GO:0005839	proteasome core complex

Gene overrepresentation in function category:

enrichment	p-value	GO term	description
1.11	8.43e-05	GO:0005488	binding
1.19	1.76e-04	GO:0005515	protein binding
1.64	1.31e-02	GO:0003723	RNA binding
4.38	3.26e-02	GO:0043021	ribonucleoprotein binding
5.98	4.93e-02	GO:0004298	threonine-type endopeptidase activity
5.98	4.93e-02	GO:0070003	threonine-type peptidase activity