Motif ID: LHX3,4.p2

Z-value: 1.308


Transcription factors associated with LHX3,4.p2:

Gene SymbolEntrez IDGene Name
LHX3 8022 LIM homeobox 3
LHX4 89884 LIM homeobox 4

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.p-valuePlot
LHX3chr9_-_1390948860.582.2e-03Click!
LHX4chr1_+_180199432-0.359.0e-02Click!


Activity profile for motif LHX3,4.p2.

activity profile for motif LHX3,4.p2


Sorted Z-values histogram for motif LHX3,4.p2

Sorted Z-values for motif LHX3,4.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of LHX3,4.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr8_+_17396285 13.687 NM_001164771
NM_003046
SLC7A2

solute carrier family 7 (cationic amino acid transporter, y+ system), member 2

chr6_-_29527701 10.573 NM_006398
UBD
ubiquitin D
chr7_-_92777657 10.459 NM_152703
SAMD9L
sterile alpha motif domain containing 9-like
chr4_-_76957139 8.727 NM_005409
CXCL11
chemokine (C-X-C motif) ligand 11
chr10_+_91152321 7.343 NM_001548
IFIT1
interferon-induced protein with tetratricopeptide repeats 1
chr4_-_76944585 5.263 NM_001565
CXCL10
chemokine (C-X-C motif) ligand 10
chr1_-_150738292 4.452 NM_001199739
NM_004079
CTSS

cathepsin S

chr9_+_118916069 4.319 NM_002581
PAPPA
pregnancy-associated plasma protein A, pappalysin 1
chr1_-_150738232 4.301 CTSS
cathepsin S
chr21_+_43619798 4.175 NM_207627
NM_207628
ABCG1

ATP-binding cassette, sub-family G (WHITE), member 1

chr7_-_139763520 4.044 NM_022750
PARP12
poly (ADP-ribose) polymerase family, member 12
chr3_-_79817058 3.923 NM_002941
ROBO1
roundabout, axon guidance receptor, homolog 1 (Drosophila)
chr6_+_26440699 3.675 NM_001242803
NM_006994
NM_197974
BTN3A3


butyrophilin, subfamily 3, member A3


chr1_-_150738255 3.630 CTSS
cathepsin S
chr12_-_16760935 3.461 NM_001001395
NM_001243609
LMO3

LIM domain only 3 (rhombotin-like 2)

chr3_-_157221362 3.284 NM_001167915
NM_001167916
VEPH1

ventricular zone expressed PH domain homolog 1 (zebrafish)

chr5_-_150467220 3.205 NM_001252390
TNIP1
TNFAIP3 interacting protein 1
chr15_+_67418053 3.181 NM_001145102
SMAD3
SMAD family member 3
chr4_-_122148620 3.126 NM_001244764
TNIP3
TNFAIP3 interacting protein 3
chr2_+_162272892 3.110 TBR1
T-box, brain, 1
chr7_-_107880492 3.066 NM_001037132
NRCAM
neuronal cell adhesion molecule
chr5_-_59783885 2.951 NM_001165899
PDE4D
phosphodiesterase 4D, cAMP-specific
chr11_-_117748200 2.865 NM_001164831
FXYD6
FXYD domain containing ion transport regulator 6
chr6_+_114178516 2.839 NM_002356
MARCKS
myristoylated alanine-rich protein kinase C substrate
chr3_-_78666943 2.764 ROBO1
roundabout, axon guidance receptor, homolog 1 (Drosophila)
chr15_+_34261088 2.696 NM_012125
CHRM5
cholinergic receptor, muscarinic 5
chrX_+_144908927 2.686 NM_004709
CXorf1
chromosome X open reading frame 1
chr8_+_54764367 2.655 NM_170587
RGS20
regulator of G-protein signaling 20
chr2_+_102979096 2.557 NM_003855
IL18R1
interleukin 18 receptor 1
chr4_+_186990308 2.479 NM_003265
TLR3
toll-like receptor 3
chr5_-_58882274 2.210 NM_006203
PDE4D
phosphodiesterase 4D, cAMP-specific
chr7_-_25268057 2.200 NM_022150
NPVF
neuropeptide VF precursor
chr6_+_26402464 2.196 NM_001145008
NM_001145009
NM_007048
NM_194441
BTN3A1



butyrophilin, subfamily 3, member A1



chr12_+_54410893 2.100 HOXC5
HOXC6
homeobox C5
homeobox C6
chr4_+_74606222 2.075 NM_000584
IL8
interleukin 8
chr5_-_13944588 2.000 NM_001369
DNAH5
dynein, axonemal, heavy chain 5
chr9_-_85882093 1.999 NM_001244962
FRMD3
FERM domain containing 3
chr5_-_160279045 1.930 NM_025153
ATP10B
ATPase, class V, type 10B
chr3_-_57234279 1.914 NM_003865
HESX1
HESX homeobox 1
chr8_+_104310660 1.852 NM_001164615
FZD6
frizzled family receptor 6
chr3_-_112564789 1.834 NM_001008784
NM_001199215
CD200R1L

CD200 receptor 1-like

chr5_+_67586466 1.778 NM_181504
PIK3R1
phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
chr20_+_5987897 1.746 NM_001127458
CRLS1
cardiolipin synthase 1
chr4_+_77953942 1.714 SEPT11
septin 11
chr5_-_58295758 1.693 NM_001197223
PDE4D
phosphodiesterase 4D, cAMP-specific
chr2_-_175712276 1.656 NM_001206602
CHN1
chimerin (chimaerin) 1
chr1_-_89664510 1.649 NM_052941
GBP4
guanylate binding protein 4
chr5_-_58571916 1.604 NM_001197220
PDE4D
phosphodiesterase 4D, cAMP-specific
chr2_+_168043792 1.568 NM_001199144
NM_001199145
XIRP2

xin actin-binding repeat containing 2

chr10_+_91087601 1.552 NM_001549
IFIT3
interferon-induced protein with tetratricopeptide repeats 3
chr12_+_113376001 1.544 OAS3
2'-5'-oligoadenylate synthetase 3, 100kDa
chr5_+_96212167 1.533 ERAP2
endoplasmic reticulum aminopeptidase 2
chr7_+_28452143 1.469 NM_182898
CREB5
cAMP responsive element binding protein 5
chrX_+_50027539 1.454 NM_033031
NM_033670
CCNB3

cyclin B3

chr1_+_206643830 1.448 IKBKE
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
chr6_+_31913852 1.446 CFB
complement factor B
chr11_-_102651321 1.425 NM_002425
MMP10
matrix metallopeptidase 10 (stromelysin 2)
chr16_+_70657894 1.423 NM_001172772
IL34
interleukin 34
chr1_+_79115476 1.404 NM_006417
IFI44
interferon-induced protein 44
chr2_-_31352489 1.403 NM_001253827
GALNT14
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 14 (GalNAc-T14)
chr6_+_12717036 1.399 NM_001242648
NM_030948
PHACTR1

phosphatase and actin regulator 1

chr1_-_231005334 1.392 NM_001136494
C1orf198
chromosome 1 open reading frame 198
chr5_+_67588395 1.389 NM_001242466
PIK3R1
phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
chr19_+_7504573 1.366 NM_001130955
ARHGEF18
Rho/Rac guanine nucleotide exchange factor (GEF) 18
chr3_+_11294384 1.359 NM_000861
HRH1
histamine receptor H1
chr6_+_31913708 1.353 NM_001710
CFB
complement factor B
chrX_-_132162297 1.342 NM_031907
USP26
ubiquitin specific peptidase 26
chr17_-_39165343 1.338 NM_031958
KRTAP3-1
keratin associated protein 3-1
chr12_+_9980076 1.334 NM_016523
KLRF1
killer cell lectin-like receptor subfamily F, member 1
chr6_+_55039070 1.333 NM_001526
HCRTR2
hypocretin (orexin) receptor 2
chr20_-_18477811 1.310 NM_006606
RBBP9
retinoblastoma binding protein 9
chr4_-_120243257 1.301 NM_000134
FABP2
fatty acid binding protein 2, intestinal
chr6_+_31553955 1.284 NM_205838
NM_205839
LST1

leukocyte specific transcript 1

chr1_+_206643786 1.282 IKBKE
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
chr4_-_122137781 1.281 NM_001128843
TNIP3
TNFAIP3 interacting protein 3
chr1_-_154578775 1.271 NM_001193495
ADAR
adenosine deaminase, RNA-specific
chr6_+_31913763 1.243 CFB
complement factor B
chr7_-_139762339 1.230 PARP12
poly (ADP-ribose) polymerase family, member 12
chr5_-_1882764 1.228 NM_016358
IRX4
iroquois homeobox 4
chr8_+_132991171 1.215 EFR3A
EFR3 homolog A (S. cerevisiae)
chr7_-_122339186 1.211 NM_139175
RNF133
ring finger protein 133
chr5_-_16742336 1.208 MYO10
myosin X
chr2_+_152214105 1.205 NM_007115
TNFAIP6
tumor necrosis factor, alpha-induced protein 6
chr11_-_71524890 1.199 LOC285407
asparagine-linked glycosylation 1 homolog pseudogene
chr17_-_49124128 1.198 NM_001251971
SPAG9
sperm associated antigen 9
chr3_+_149192367 1.191 NM_004617
TM4SF4
transmembrane 4 L six family member 4
chr19_-_3557566 1.182 NM_001042680
NM_021731
NM_174983
MFSD12


major facilitator superfamily domain containing 12


chr11_-_5345530 1.180 NM_033180
OR51B2
olfactory receptor, family 51, subfamily B, member 2
chr7_+_18548899 1.153 NM_001204147
NM_001204148
HDAC9

histone deacetylase 9

chr2_-_99871569 1.144 NM_175735
LYG2
lysozyme G-like 2
chrX_+_140982451 1.143 NM_177456
MAGEC3
melanoma antigen family C, 3
chr6_+_123317377 1.138 CLVS2
clavesin 2
chrX_-_110655384 1.137 NM_178151
NM_001195553
NM_178152
NM_178153
DCX



doublecortin



chr3_-_11623829 1.127 NM_001128220
VGLL4
vestigial like 4 (Drosophila)
chr9_+_111624545 1.120 NM_006687
ACTL7A
actin-like 7A
chr1_+_155853546 1.119 SYT11
synaptotagmin XI
chr15_+_100173182 1.113 NM_001130928
MEF2A
myocyte enhancer factor 2A
chr12_-_89920038 1.105 NM_001199781
NM_001199782
NM_172240
POC1B-GALNT4

POC1B
POC1B-GALNT4 readthrough

POC1 centriolar protein homolog B (Chlamydomonas)
chr1_+_50574601 1.100 ELAVL4
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)
chr5_-_156485969 1.088 NM_001173393
HAVCR1
hepatitis A virus cellular receptor 1
chr5_-_156486128 1.087 HAVCR1
hepatitis A virus cellular receptor 1
chr5_+_6746100 1.066 NM_001171806
PAPD7
PAP associated domain containing 7
chr8_-_57026540 1.036 NM_005372
MOS
v-mos Moloney murine sarcoma viral oncogene homolog
chr2_+_102508333 1.035 MAP4K4
mitogen-activated protein kinase kinase kinase kinase 4
chr2_+_27719702 1.026 NM_001486
GCKR
glucokinase (hexokinase 4) regulator
chr6_-_169654047 1.021 NM_003247
THBS2
thrombospondin 2
chr21_-_32185560 1.000 NM_175857
KRTAP8-1
keratin associated protein 8-1
chr17_-_39093671 0.994 NM_015515
KRT23
keratin 23 (histone deacetylase inducible)
chr1_-_153321021 0.993 NM_020393
PGLYRP4
peptidoglycan recognition protein 4
chr3_+_130569368 0.986 NM_001199180
NM_001199181
NM_001199182
ATP2C1


ATPase, Ca++ transporting, type 2C, member 1


chrX_+_70765479 0.982 OGT
O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase)
chrX_-_15332680 0.980 NM_001012428
ASB11
ankyrin repeat and SOCS box containing 11
chr9_+_12693385 0.959 NM_000550
TYRP1
tyrosinase-related protein 1
chr3_-_119582422 0.957 GSK3B
glycogen synthase kinase 3 beta
chr14_+_29236171 0.945 NM_005249
FOXG1
forkhead box G1
chr17_-_39254374 0.936 NM_031960
KRTAP4-8
keratin associated protein 4-8
chrX_+_99839789 0.929 NM_022144
TNMD
tenomodulin
chr10_-_75335415 0.920 NM_152586
USP54
ubiquitin specific peptidase 54
chr16_-_72128214 0.918 NM_001142318
TXNL4B
thioredoxin-like 4B
chr10_+_18549583 0.911 NM_000724
CACNB2
calcium channel, voltage-dependent, beta 2 subunit
chr1_-_205325915 0.897 NM_018203
KLHDC8A
kelch domain containing 8A
chr21_+_25801042 0.896 FLJ42200
FLJ42200 protein
chr3_+_101546833 0.894 NM_001005474
NFKBIZ
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta
chr1_-_149900143 0.891 NM_005850
SF3B4
splicing factor 3b, subunit 4, 49kDa
chr3_-_167191808 0.885 NM_006217
SERPINI2
serpin peptidase inhibitor, clade I (pancpin), member 2
chr1_+_174417211 0.885 NM_005684
GPR52
G protein-coupled receptor 52
chr12_-_46633551 0.883 SLC38A1
solute carrier family 38, member 1
chr1_+_179560747 0.867 NM_001199091
NM_001199085
NM_173533
TDRD5


tudor domain containing 5


chr18_+_61582744 0.857 NM_005024
SERPINB10
serpin peptidase inhibitor, clade B (ovalbumin), member 10
chr10_+_24755459 0.855 KIAA1217
KIAA1217
chr13_+_109248499 0.852 NM_015011
MYO16
myosin XVI
chr3_-_71294229 0.851 NM_001244814
FOXP1
forkhead box P1
chr3_-_157213138 0.845 NM_001167917
VEPH1
ventricular zone expressed PH domain homolog 1 (zebrafish)
chr5_+_60933635 0.841 NM_173667
C5orf64
chromosome 5 open reading frame 64
chr21_-_31538970 0.833 NM_012131
CLDN17
claudin 17
chr6_-_87804773 0.828 NM_000735
NM_001252383
CGA

glycoprotein hormones, alpha polypeptide

chr10_-_61900659 0.828 NM_001149
ANK3
ankyrin 3, node of Ranvier (ankyrin G)
chr1_+_50574589 0.827 NM_001144774
NM_021952
ELAVL4

ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)

chr4_+_175839508 0.823 NM_001130703
NM_001130704
NM_001130705
NM_014269
ADAM29



ADAM metallopeptidase domain 29



chr5_+_147691988 0.814 NM_032566
SPINK7
serine peptidase inhibitor, Kazal type 7 (putative)
chr16_+_2732526 0.810 KCTD5
potassium channel tetramerisation domain containing 5
chr9_-_15250113 0.806 NM_001168342
TTC39B
tetratricopeptide repeat domain 39B
chr3_-_108672547 0.805 NM_005459
GUCA1C
guanylate cyclase activator 1C
chr20_+_31805118 0.803 NM_001042439
NM_178466
BPIFA3

BPI fold containing family A, member 3

chr3_-_150920946 0.800 NM_013308
GPR171
G protein-coupled receptor 171
chr10_+_102732285 0.795 NM_001203244
NM_017893
SEMA4G

sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4G

chr11_-_126870654 0.792 KIRREL3
kin of IRRE like 3 (Drosophila)
chrX_-_102531673 0.789 NM_001012979
TCEAL5
transcription elongation factor A (SII)-like 5
chr20_-_7921068 0.788 NM_017545
HAO1
hydroxyacid oxidase (glycolate oxidase) 1
chr11_-_117698727 0.788 NM_021603
FXYD2
FXYD domain containing ion transport regulator 2
chr14_+_67831484 0.786 EIF2S1
eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa
chr3_+_171561138 0.783 NM_001164436
TMEM212
transmembrane protein 212
chr16_+_2732475 0.779 NM_018992
KCTD5
potassium channel tetramerisation domain containing 5
chr13_-_70682458 0.768 NM_020866
KLHL1
kelch-like 1 (Drosophila)
chrX_-_77225134 0.763 NM_001029891
PGAM4
phosphoglycerate mutase family member 4
chr16_-_12010518 0.763 NM_001130007
GSPT1
G1 to S phase transition 1
chr12_-_52761254 0.759 NM_002283
KRT85
keratin 85
chr12_-_53994783 0.757 NM_001130059
ATF7
activating transcription factor 7
chr6_+_26365397 0.755 NM_001197247
NM_001197249
NM_007047
NM_001197248
BTN3A2



butyrophilin, subfamily 3, member A2



chr1_-_57045235 0.753 NM_003713
PPAP2B
phosphatidic acid phosphatase type 2B
chr14_+_75898836 0.745 NM_001135049
JDP2
Jun dimerization protein 2
chr6_-_134639195 0.742 NM_001143676
SGK1
serum/glucocorticoid regulated kinase 1
chr3_+_132036276 0.737 ACPP
acid phosphatase, prostate
chr11_+_124095343 0.729 NM_001007249
OR8G2
olfactory receptor, family 8, subfamily G, member 2
chrX_-_13835012 0.728 GPM6B
glycoprotein M6B
chr11_+_5710816 0.725 NM_001199573
NM_006074
TRIM22

tripartite motif containing 22

chr6_-_27835308 0.725 NM_005322
HIST1H1B
histone cluster 1, H1b
chr22_-_22863504 0.718 NM_080764
ZNF280B
zinc finger protein 280B
chr17_+_51900238 0.713 NM_032559
KIF2B
kinesin family member 2B
chr10_+_102222797 0.712 NM_003393
WNT8B
wingless-type MMTV integration site family, member 8B
chr17_-_64225496 0.708 NM_000042
APOH
apolipoprotein H (beta-2-glycoprotein I)
chr8_-_90996785 0.698 NBN
nibrin
chr1_+_206643585 0.696 NM_001193321
NM_001193322
NM_014002
IKBKE


inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon


chr5_+_166711842 0.695 NM_001122679
ODZ2
odz, odd Oz/ten-m homolog 2 (Drosophila)
chr11_+_55594694 0.692 NM_001004739
OR5L2
olfactory receptor, family 5, subfamily L, member 2
chr14_+_95027760 0.686 NM_006215
SERPINA4
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 4
chr13_-_36050758 0.682 NM_005584
MAB21L1
mab-21-like 1 (C. elegans)
chr1_-_33430285 0.679 NM_001127361
NM_153341
RNF19B

ring finger protein 19B

chr2_-_231989755 0.672 NM_000867
HTR2B
5-hydroxytryptamine (serotonin) receptor 2B
chr11_-_126870685 0.672 NM_001161707
NM_032531
KIRREL3

kin of IRRE like 3 (Drosophila)

chr6_+_64231626 0.671 PTP4A1
protein tyrosine phosphatase type IVA, member 1
chr4_+_169418167 0.671 NM_001166108
NM_016081
PALLD

palladin, cytoskeletal associated protein

chr5_-_124080773 0.669 NM_020747
ZNF608
zinc finger protein 608
chr2_+_68961912 0.668 NM_001007231
NM_001166277
ARHGAP25

Rho GTPase activating protein 25

chr22_-_50971007 0.663 NM_001014440
ODF3B
outer dense fiber of sperm tails 3B
chr11_+_71900958 0.661 NM_000802
FOLR1
folate receptor 1 (adult)
chr18_-_3845295 0.661 NM_001003809
NM_001242765
NM_001242766
DLGAP1


discs, large (Drosophila) homolog-associated protein 1


chr10_+_118083939 0.659 NM_198515
C10orf96
chromosome 10 open reading frame 96
chr12_-_15091441 0.654 NM_152321
ERP27
endoplasmic reticulum protein 27
chr21_-_27423423 0.654


chr18_-_13915534 0.650 NM_000529
MC2R
melanocortin 2 receptor (adrenocorticotropic hormone)
chr22_+_23487512 0.648 NM_004914
RAB36
RAB36, member RAS oncogene family
chr7_-_126883568 0.642 NM_000845
GRM8
glutamate receptor, metabotropic 8
chr4_+_71263598 0.636 NM_021225
PROL1
proline rich, lacrimal 1
chr3_+_63953419 0.636 NM_001128149
ATXN7
ataxin 7
chr8_+_104311058 0.636 NM_001164616
NM_003506
FZD6

frizzled family receptor 6

chr12_-_26277807 0.635 NM_030762
BHLHE41
basic helix-loop-helix family, member e41
chr8_+_123794043 0.631 ZHX2
zinc fingers and homeoboxes 2
chr3_+_46411632 0.631 NM_000579
NM_001100168
CCR5

chemokine (C-C motif) receptor 5

chr7_+_141695678 0.629 NM_004668
MGAM
maltase-glucoamylase (alpha-glucosidase)

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.27 4.17e-03 GO:0032501 multicellular organismal process
1.22 1.11e-02 GO:0050896 response to stimulus

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.36 1.23e-05 GO:0005886 plasma membrane
1.35 1.81e-05 GO:0071944 cell periphery
1.53 1.96e-05 GO:0044459 plasma membrane part
1.54 1.75e-02 GO:0005887 integral to plasma membrane
2.13 2.46e-02 GO:0005578 proteinaceous extracellular matrix
1.51 3.30e-02 GO:0031226 intrinsic to plasma membrane
2.73 4.67e-02 GO:0034703 cation channel complex

Gene overrepresentation in function category:

enrichment   p-value GO term description
2.08 1.06e-02 GO:0022838 substrate-specific channel activity
2.05 1.76e-02 GO:0005216 ion channel activity
2.01 2.06e-02 GO:0015267 channel activity
2.01 2.17e-02 GO:0022803 passive transmembrane transporter activity
1.61 3.96e-02 GO:0022857 transmembrane transporter activity
2.75 4.47e-02 GO:0022843 voltage-gated cation channel activity
1.69 4.57e-02 GO:0015075 ion transmembrane transporter activity
21.71 4.69e-02 GO:0034056 estrogen response element binding