Motif ID: MTF1.p2

Z-value: 1.028


Transcription factors associated with MTF1.p2:

Gene SymbolEntrez IDGene Name
MTF1 4520 metal-regulatory transcription factor 1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.p-valuePlot
MTF1chr1_-_383252240.331.1e-01Click!


Activity profile for motif MTF1.p2.

activity profile for motif MTF1.p2


Sorted Z-values histogram for motif MTF1.p2

Sorted Z-values for motif MTF1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of MTF1.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr9_-_95896498 2.516 NM_004148
 NINJ1
ninjurin 1
chr3_-_39195034 1.676 CSRNP1
cysteine-serine-rich nuclear protein 1
chr3_-_39195101 1.662 NM_033027
 CSRNP1
cysteine-serine-rich nuclear protein 1
chr7_+_86273867 1.160 GRM3
glutamate receptor, metabotropic 3
chr16_-_89007605 1.127 NM_175931
 CBFA2T3
core-binding factor, runt domain, alpha subunit 2; translocated to, 3
chr11_+_369723 1.122 NM_178537
 B4GALNT4
beta-1,4-N-acetyl-galactosaminyl transferase 4
chr9_+_137218324 1.118 RXRA
retinoid X receptor, alpha
chr16_+_56703725 1.109 NM_005951
 MT1H
metallothionein 1H
chr7_-_139477437 1.096 NM_001113239
NM_022740
 HIPK2

homeodomain interacting protein kinase 2

chr16_+_56642477 1.088 NM_005953
 MT2A
metallothionein 2A
chr21_+_42797977 1.074 NM_002462
NM_001178046
 MX1

myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)

chr9_+_116918230 1.074 NM_032888
 COL27A1
collagen, type XXVII, alpha 1
chr3_-_45267804 1.044 NM_015444
 TMEM158
transmembrane protein 158 (gene/pseudogene)
chr6_-_143266283 1.007 NM_006734
 HIVEP2
human immunodeficiency virus type I enhancer binding protein 2
chr17_-_37307888 0.997 NM_020405
 PLXDC1
plexin domain containing 1
chr15_+_90544608 0.997 NM_198526
 ZNF710
zinc finger protein 710
chr8_-_145515014 0.923 BOP1
block of proliferation 1
chr21_+_45285026 0.887 AGPAT3
1-acylglycerol-3-phosphate O-acyltransferase 3
chr20_+_6748744 0.828 NM_001200
 BMP2
bone morphogenetic protein 2
chr16_+_56716378 0.822 NM_005952
 MT1X
metallothionein 1X

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 147 entries
enrichment   p-value GO term description
2.43 4.47e-02 GO:0007266 Rho protein signal transduction
2.03 2.72e-04 GO:0007265 Ras protein signal transduction
2.00 2.64e-02 GO:0060828 regulation of canonical Wnt receptor signaling pathway
1.98 5.25e-03 GO:0010720 positive regulation of cell development
1.91 1.75e-03 GO:0030111 regulation of Wnt receptor signaling pathway
1.82 2.29e-02 GO:0010769 regulation of cell morphogenesis involved in differentiation
1.81 3.00e-02 GO:0022604 regulation of cell morphogenesis
1.76 3.63e-05 GO:0050767 regulation of neurogenesis
1.76 1.10e-04 GO:0048011 nerve growth factor receptor signaling pathway
1.74 1.07e-03 GO:0045664 regulation of neuron differentiation
1.72 3.15e-02 GO:0010553 negative regulation of gene-specific transcription from RNA polymerase II promoter
1.70 5.61e-05 GO:0051960 regulation of nervous system development
1.68 5.50e-06 GO:0007411 axon guidance
1.68 1.40e-05 GO:0060284 regulation of cell development
1.68 4.24e-02 GO:0030900 forebrain development
1.66 8.38e-05 GO:0022603 regulation of anatomical structure morphogenesis
1.65 4.05e-07 GO:0007409 axonogenesis
1.64 4.83e-02 GO:0032582 negative regulation of gene-specific transcription
1.63 8.28e-07 GO:0048667 cell morphogenesis involved in neuron differentiation
1.63 1.48e-05 GO:0010551 regulation of gene-specific transcription from RNA polymerase II promoter

Gene overrepresentation in compartment category:

Showing 1 to 20 of 23 entries
enrichment   p-value GO term description
1.40 1.89e-02 GO:0045202 synapse
1.33 2.03e-02 GO:0030054 cell junction
1.30 2.06e-02 GO:0044451 nucleoplasm part
1.27 2.01e-02 GO:0042995 cell projection
1.24 2.71e-03 GO:0005654 nucleoplasm
1.24 4.41e-02 GO:0005794 Golgi apparatus
1.23 2.16e-04 GO:0031981 nuclear lumen
1.21 8.12e-05 GO:0044459 plasma membrane part
1.18 4.18e-03 GO:0070013 intracellular organelle lumen
1.18 4.46e-03 GO:0044428 nuclear part
1.18 6.38e-03 GO:0005829 cytosol
1.17 1.09e-02 GO:0043233 organelle lumen
1.16 1.46e-02 GO:0031974 membrane-enclosed lumen
1.14 1.99e-07 GO:0005634 nucleus
1.11 1.54e-08 GO:0005737 cytoplasm
1.09 3.35e-07 GO:0043227 membrane-bounded organelle
1.09 4.24e-07 GO:0043231 intracellular membrane-bounded organelle
1.08 1.53e-11 GO:0044424 intracellular part
1.08 2.05e-11 GO:0005622 intracellular
1.07 2.60e-05 GO:0043226 organelle

Gene overrepresentation in function category:

Showing 1 to 20 of 27 entries
enrichment   p-value GO term description
2.89 3.94e-02 GO:0005326 neurotransmitter transporter activity
1.83 6.70e-03 GO:0030674 protein binding, bridging
1.79 9.71e-03 GO:0060090 binding, bridging
1.62 5.68e-05 GO:0016564 transcription repressor activity
1.61 6.83e-05 GO:0016563 transcription activator activity
1.59 1.71e-02 GO:0000975 regulatory region DNA binding
1.59 1.71e-02 GO:0001067 regulatory region nucleic acid binding
1.59 1.71e-02 GO:0044212 transcription regulatory region DNA binding
1.59 2.85e-02 GO:0010843 promoter binding
1.51 6.39e-05 GO:0019904 protein domain specific binding
1.44 7.96e-10 GO:0030528 transcription regulator activity
1.43 2.05e-05 GO:0043565 sequence-specific DNA binding
1.38 9.24e-07 GO:0001071 nucleic acid binding transcription factor activity
1.38 9.24e-07 GO:0003700 sequence-specific DNA binding transcription factor activity
1.38 1.49e-03 GO:0004672 protein kinase activity
1.37 1.29e-04 GO:0016301 kinase activity
1.37 2.96e-04 GO:0016773 phosphotransferase activity, alcohol group as acceptor
1.33 4.50e-04 GO:0016772 transferase activity, transferring phosphorus-containing groups
1.33 3.04e-03 GO:0019899 enzyme binding
1.22 1.53e-03 GO:0016740 transferase activity