Motif ID: NANOG.p2

Z-value: 0.847


Transcription factors associated with NANOG.p2:

Gene SymbolEntrez IDGene Name
NANOG 79923 Nanog homeobox

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.p-valuePlot
NANOGchr12_+_79420250.376.6e-02Click!


Activity profile for motif NANOG.p2.

activity profile for motif NANOG.p2


Sorted Z-values histogram for motif NANOG.p2

Sorted Z-values for motif NANOG.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NANOG.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr12_-_52779362 3.063 NM_033045
KRT84
keratin 84
chr5_-_35938736 1.565 NM_001042625
NM_144647
CAPSL

calcyphosine-like

chr12_-_16760935 1.391 NM_001001395
NM_001243609
LMO3

LIM domain only 3 (rhombotin-like 2)

chr17_-_39165343 1.363 NM_031958
KRTAP3-1
keratin associated protein 3-1
chr5_-_150467220 1.305 NM_001252390
TNIP1
TNFAIP3 interacting protein 1
chr12_-_105322056 1.256 NM_032148
SLC41A2
solute carrier family 41, member 2
chr2_+_152214105 1.246 NM_007115
TNFAIP6
tumor necrosis factor, alpha-induced protein 6
chr1_+_15990300 1.178


chr11_-_57195052 1.051 NM_017611
SLC43A3
solute carrier family 43, member 3
chr1_-_150738232 1.043 CTSS
cathepsin S
chr18_+_55888750 0.986 NM_001144966
NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like
chr9_+_109625347 0.971 NM_021224
ZNF462
zinc finger protein 462
chr9_+_12693385 0.970 NM_000550
TYRP1
tyrosinase-related protein 1
chr13_+_109281569 0.948 NM_001198950
MYO16
myosin XVI
chr16_+_57406398 0.934 NM_002996
CX3CL1
chemokine (C-X3-C motif) ligand 1
chr3_-_74570262 0.917 NM_020872
CNTN3
contactin 3 (plasmacytoma associated)
chr14_+_51955854 0.910 NM_001042481
FRMD6
FERM domain containing 6
chr18_+_55888799 0.894 NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like
chr15_-_55562483 0.893 NM_183234
NM_004580
RAB27A

RAB27A, member RAS oncogene family

chr18_-_51880942 0.885 NM_139171
STARD6
StAR-related lipid transfer (START) domain containing 6
chr18_+_55888838 0.869 NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like
chr9_+_118916069 0.849 NM_002581
PAPPA
pregnancy-associated plasma protein A, pappalysin 1
chr3_-_123339423 0.836 NM_053031
NM_053032
MYLK

myosin light chain kinase

chr10_-_13749622 0.830 FRMD4A
FERM domain containing 4A
chr1_-_150738292 0.813 NM_001199739
NM_004079
CTSS

cathepsin S

chr5_+_140809957 0.782 PCDHGA12
protocadherin gamma subfamily A, 12
chr2_+_162272892 0.778 TBR1
T-box, brain, 1
chr7_-_92777657 0.759 NM_152703
SAMD9L
sterile alpha motif domain containing 9-like
chr17_-_49124128 0.754 NM_001251971
SPAG9
sperm associated antigen 9
chr5_-_148758787 0.746 NM_014443
IL17B
interleukin 17B
chr6_+_34206567 0.741 NM_145905
HMGA1
high mobility group AT-hook 1
chr10_-_14372807 0.740 NM_018027
FRMD4A
FERM domain containing 4A
chr10_+_114133775 0.736 ACSL5
acyl-CoA synthetase long-chain family member 5
chr2_-_180427314 0.736 NM_001113398
ZNF385B
zinc finger protein 385B
chr15_-_55563091 0.732 NM_183236
RAB27A
RAB27A, member RAS oncogene family
chr5_+_169780880 0.731 NM_001034838
KCNIP1
Kv channel interacting protein 1
chr3_-_11623829 0.727 NM_001128220
VGLL4
vestigial like 4 (Drosophila)
chr6_+_131571298 0.707 NM_004842
NM_138633
AKAP7

A kinase (PRKA) anchor protein 7

chr1_+_50574601 0.705 ELAVL4
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)
chr2_-_69098502 0.704 NM_014482
BMP10
bone morphogenetic protein 10
chr5_-_36301999 0.702 NM_001161429
NM_145000
RANBP3L

RAN binding protein 3-like

chr12_-_16759939 0.698 NM_001243613
LMO3
LIM domain only 3 (rhombotin-like 2)
chr21_+_43710190 0.687 ABCG1
ATP-binding cassette, sub-family G (WHITE), member 1
chr7_+_28725597 0.680 NM_001011666
CREB5
cAMP responsive element binding protein 5
chr17_-_39150384 0.676 NM_033185
KRTAP3-3
keratin associated protein 3-3
chr3_-_123339178 0.674 MYLK
myosin light chain kinase
chr4_-_122137781 0.663 NM_001128843
TNIP3
TNFAIP3 interacting protein 3
chr12_-_16759733 0.661 NM_001243610
LMO3
LIM domain only 3 (rhombotin-like 2)
chr11_-_102496049 0.660 NM_004771
MMP20
matrix metallopeptidase 20
chr3_-_46068978 0.660 NM_001024644
NM_005283
XCR1

chemokine (C motif) receptor 1

chr18_+_21572736 0.658 NM_153211
TTC39C
tetratricopeptide repeat domain 39C
chr10_-_21435487 0.644 NM_001010896
NM_001177483
C10orf113

chromosome 10 open reading frame 113

chr14_+_23305816 0.640 MMP14
matrix metallopeptidase 14 (membrane-inserted)
chr5_+_125758818 0.628 NM_001146320
NM_001146321
NM_023927
GRAMD3


GRAM domain containing 3


chr7_+_18535351 0.617 NM_001204145
NM_001204146
NM_014707
NM_178423
HDAC9



histone deacetylase 9



chr7_-_107880492 0.609 NM_001037132
NRCAM
neuronal cell adhesion molecule
chr18_-_31803168 0.608 NOL4
nucleolar protein 4
chr1_+_167298382 0.601 POU2F1
POU class 2 homeobox 1
chr2_+_169757749 0.595 NM_001081686
NM_021176
G6PC2

glucose-6-phosphatase, catalytic, 2

chr14_-_57272344 0.589 NM_172337
OTX2
orthodenticle homeobox 2
chr21_-_36421586 0.579 NM_001754
RUNX1
runt-related transcription factor 1
chr21_-_36421630 0.578 RUNX1
runt-related transcription factor 1
chr17_-_39324423 0.577 NM_033187
KRTAP4-3
keratin associated protein 4-3
chr3_-_123411185 0.571 MYLK
myosin light chain kinase
chr3_+_129247481 0.570 NM_000539
RHO
rhodopsin
chr8_+_32504250 0.568 NM_013959
NRG1
neuregulin 1
chr17_-_40337384 0.563 NM_001524
HCRT
hypocretin (orexin) neuropeptide precursor
chr15_+_49715374 0.547 NM_002009
FGF7
fibroblast growth factor 7
chr6_+_50786438 0.542 NM_003221
TFAP2B
transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
chr18_-_31803514 0.532 NM_001198546
NM_001198548
NM_003787
NOL4


nucleolar protein 4


chr12_-_52828105 0.527 NM_004693
KRT75
keratin 75
chr13_-_95131718 0.512 NM_001129889
NM_001922
DCT

dopachrome tautomerase (dopachrome delta-isomerase, tyrosine-related protein 2)

chr1_-_152386727 0.511 NM_016190
CRNN
cornulin
chr1_+_167298280 0.510 NM_001198783
POU2F1
POU class 2 homeobox 1
chr8_-_7287651 0.508 NM_018661
DEFB103B
defensin, beta 103B
chr7_-_115670774 0.507 TFEC
transcription factor EC
chr3_+_63884074 0.502 NM_001177387
ATXN7
ataxin 7
chr7_+_114055171 0.499 FOXP2
forkhead box P2
chr14_+_23305792 0.498 NM_004995
MMP14
matrix metallopeptidase 14 (membrane-inserted)
chr2_+_210444154 0.494 MAP2
microtubule-associated protein 2
chr11_-_16424391 0.493 NM_001145819
NM_017508
SOX6

SRY (sex determining region Y)-box 6

chr10_+_114133838 0.489 NM_203379
ACSL5
acyl-CoA synthetase long-chain family member 5
chr5_+_147258273 0.488 NM_054023
SCGB3A2
secretoglobin, family 3A, member 2
chr1_-_116383692 0.486 NM_005599
NHLH2
nescient helix loop helix 2
chr12_-_52761254 0.481 NM_002283
KRT85
keratin 85
chr4_-_123542165 0.480 NM_001207006
NM_021803
IL21

interleukin 21

chr12_-_57328044 0.474 NM_148897
SDR9C7
short chain dehydrogenase/reductase family 9C, member 7
chr7_+_28452143 0.471 NM_182898
CREB5
cAMP responsive element binding protein 5
chr4_-_122148620 0.468 NM_001244764
TNIP3
TNFAIP3 interacting protein 3
chr1_+_90286469 0.465 NM_001134479
LRRC8D
leucine rich repeat containing 8 family, member D
chr6_-_31107110 0.465 NM_014069
PSORS1C2
psoriasis susceptibility 1 candidate 2
chr8_+_32579350 0.464 NM_001159996
NRG1
neuregulin 1
chr8_-_40755328 0.462 NM_001135731
NM_024645
ZMAT4

zinc finger, matrin-type 4

chr15_+_89631625 0.460 ABHD2
abhydrolase domain containing 2
chr6_+_34204928 0.452 HMGA1
high mobility group AT-hook 1
chr8_-_10512616 0.448 NM_178857
RP1L1
retinitis pigmentosa 1-like 1
chr11_-_5345530 0.446 NM_033180
OR51B2
olfactory receptor, family 51, subfamily B, member 2
chr2_+_171571800 0.441 NM_001003845
SP5
Sp5 transcription factor
chr4_+_15429628 0.439 NM_031911
C1QTNF7
C1q and tumor necrosis factor related protein 7
chr4_-_174451356 0.435 NM_021973
HAND2
heart and neural crest derivatives expressed 2
chr17_-_1248346 0.434 PAFAH1B1
platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)
chr22_-_30867944 0.430 NM_174975
SEC14L3
SEC14-like 3 (S. cerevisiae)
chr11_-_30601919 0.427 NM_001584
MPPED2
metallophosphoesterase domain containing 2
chr5_+_140810126 0.426 NM_003735
NM_032094
PCDHGA12

protocadherin gamma subfamily A, 12

chr7_+_28475233 0.422 NM_004904
CREB5
cAMP responsive element binding protein 5
chr12_-_16757944 0.418 LMO3
LIM domain only 3 (rhombotin-like 2)
chr6_-_114384008 0.409 NM_153612
HS3ST5
heparan sulfate (glucosamine) 3-O-sulfotransferase 5
chrX_+_50027539 0.404 NM_033031
NM_033670
CCNB3

cyclin B3

chr11_-_57089670 0.399 TNKS1BP1
tankyrase 1 binding protein 1, 182kDa
chr7_-_25268057 0.398 NM_022150
NPVF
neuropeptide VF precursor
chr12_-_57505176 0.397 NM_001178078
NM_001178080
NM_001178081
NM_003153
STAT6



signal transducer and activator of transcription 6, interleukin-4 induced



chr1_-_42384370 0.396 NM_001127714
NM_024503
HIVEP3

human immunodeficiency virus type I enhancer binding protein 3

chr7_+_114066554 0.394 NM_001172767
NM_148899
FOXP2

forkhead box P2

chr1_+_160160284 0.391 NM_001231
CASQ1
calsequestrin 1 (fast-twitch, skeletal muscle)
chr4_+_169013687 0.390 NM_007193
ANXA10
annexin A10
chr3_+_152880024 0.389 NM_002886
RAP2B
RAP2B, member of RAS oncogene family
chr7_+_114055048 0.387 NM_001172766
NM_014491
NM_148898
NM_148900
FOXP2



forkhead box P2



chr1_-_150738255 0.382 CTSS
cathepsin S
chr13_-_99910548 0.382 NM_001098200
NM_005292
GPR18

G protein-coupled receptor 18

chr6_+_34204690 0.378 HMGA1
high mobility group AT-hook 1
chr5_+_170736287 0.377 NM_021025
TLX3
T-cell leukemia homeobox 3
chr11_-_117747618 0.377 NM_001204268
NM_001243598
NM_001164832
NM_001164836
NM_001164837
NM_022003
FXYD6-FXYD2

FXYD6



FXYD6-FXYD2 readthrough

FXYD domain containing ion transport regulator 6



chr1_-_169703178 0.376 NM_000450
SELE
selectin E
chr2_-_55199894 0.375


chr5_+_140810181 0.374 PCDHGA12
protocadherin gamma subfamily A, 12
chr1_+_74701070 0.374 NM_015978
TNNI3K
TNNI3 interacting kinase
chr2_-_163008913 0.374 NM_002054
GCG
glucagon
chr11_+_75526211 0.362 NM_003369
UVRAG
UV radiation resistance associated gene
chr1_+_50569581 0.362 NM_001144776
ELAVL4
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)
chr16_+_56815703 0.360 NM_001242795
NUP93
nucleoporin 93kDa
chr14_-_95236351 0.359 NM_173849
GSC
goosecoid homeobox
chr8_+_24298442 0.356 NM_003817
ADAM7
ADAM metallopeptidase domain 7
chr6_-_42690308 0.355 NM_000322
PRPH2
peripherin 2 (retinal degeneration, slow)
chr10_-_52645384 0.353 A1CF
APOBEC1 complementation factor
chr11_-_117748200 0.352 NM_001164831
FXYD6
FXYD domain containing ion transport regulator 6
chr14_-_38064440 0.349 NM_004496
FOXA1
forkhead box A1
chr9_-_86584079 0.346 HNRNPK
heterogeneous nuclear ribonucleoprotein K
chr20_-_30539725 0.346 PDRG1
p53 and DNA-damage regulated 1
chr3_+_35721115 0.340 NM_001025068
NM_001025069
ARPP21

cAMP-regulated phosphoprotein, 21kDa

chr22_-_40859423 0.339 MKL1
megakaryoblastic leukemia (translocation) 1
chr2_-_180610768 0.338 NM_001113397
ZNF385B
zinc finger protein 385B
chr8_+_54764367 0.336 NM_170587
RGS20
regulator of G-protein signaling 20
chr5_-_169816637 0.335 NM_004137
KCNMB1
potassium large conductance calcium-activated channel, subfamily M, beta member 1
chr9_+_130026755 0.334 NM_032293
GARNL3
GTPase activating Rap/RanGAP domain-like 3
chr11_-_128712340 0.327 NM_000220
KCNJ1
potassium inwardly-rectifying channel, subfamily J, member 1
chr7_+_129906702 0.326 NM_001869
CPA2
carboxypeptidase A2 (pancreatic)
chr1_-_200377488 0.325 ZNF281
zinc finger protein 281
chr18_+_32173281 0.320 NM_001128175
NM_001198938
NM_001198939
NM_001198940
DTNA



dystrobrevin, alpha



chr12_-_16759531 0.318 NM_018640
LMO3
LIM domain only 3 (rhombotin-like 2)
chr8_+_86157693 0.316 NM_198584
CA13
carbonic anhydrase XIII
chr4_-_159956332 0.315 NM_152543
C4orf45
chromosome 4 open reading frame 45
chr12_-_57505121 0.315 STAT6
signal transducer and activator of transcription 6, interleukin-4 induced
chr11_-_85430117 0.314 NM_206929
SYTL2
synaptotagmin-like 2
chr7_+_129984629 0.313 NM_001127441
NM_001127442
NM_080385
CPA5


carboxypeptidase A5


chr3_-_101039403 0.313 NM_016247
IMPG2
interphotoreceptor matrix proteoglycan 2
chr1_+_209878135 0.313 NM_005525
HSD11B1
hydroxysteroid (11-beta) dehydrogenase 1
chr5_+_140810326 0.312 PCDHGA12
protocadherin gamma subfamily A, 12
chr1_-_178840079 0.312 NM_004673
ANGPTL1
angiopoietin-like 1
chr7_-_115670828 0.312 NM_001018058
NM_012252
TFEC

transcription factor EC

chr11_+_75526236 0.312 UVRAG
UV radiation resistance associated gene
chr2_-_209028288 0.310 NM_014617
CRYGA
crystallin, gamma A
chr1_-_200377262 0.310 ZNF281
zinc finger protein 281
chr3_+_115342150 0.309 NM_001130064
NM_002045
GAP43

growth associated protein 43

chr12_-_4488707 0.307 NM_020638
FGF23
fibroblast growth factor 23
chr20_+_43030005 0.306 HNF4A
hepatocyte nuclear factor 4, alpha
chr3_+_88188261 0.305 NM_018293
ZNF654
zinc finger protein 654
chr15_+_66694216 0.305 MAP2K1
mitogen-activated protein kinase kinase 1
chr11_-_58980321 0.303 NM_001039396
MPEG1
macrophage expressed 1
chr2_-_49381555 0.301 NM_000145
NM_181446
FSHR

follicle stimulating hormone receptor

chr9_+_109686436 0.299 ZNF462
zinc finger protein 462
chr2_+_36923902 0.299 VIT
vitrin
chr16_+_6823809 0.297 NM_001142334
RBFOX1
RNA binding protein, fox-1 homolog (C. elegans) 1
chr3_+_121796695 0.294 NM_006889
NM_176892
CD86

CD86 molecule

chr5_+_125759076 0.293 GRAMD3
GRAM domain containing 3
chr5_+_34687663 0.293 NM_001145523
RAI14
retinoic acid induced 14
chr16_-_73092533 0.293 NM_001164766
ZFHX3
zinc finger homeobox 3
chr15_+_89631731 0.292 ABHD2
abhydrolase domain containing 2
chr12_-_57504935 0.292 STAT6
signal transducer and activator of transcription 6, interleukin-4 induced
chr21_-_31538970 0.291 NM_012131
CLDN17
claudin 17
chr8_-_20040612 0.290 NM_001135691
NM_001142324
NM_001142325
NM_003053
SLC18A1



solute carrier family 18 (vesicular monoamine), member 1



chr2_+_171784947 0.285 NM_001201428
NM_015530
GORASP2

golgi reassembly stacking protein 2, 55kDa

chr17_+_39240412 0.283 NM_033061
KRTAP4-7
keratin associated protein 4-7
chr6_-_46293628 0.279 NM_005822
RCAN2
regulator of calcineurin 2
chr3_+_115342302 0.277 GAP43
growth associated protein 43
chr12_-_53045947 0.276 NM_000423
KRT2
keratin 2
chr1_+_50575465 0.276 ELAVL4
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)
chr22_-_17747520 0.276 CECR3
cat eye syndrome chromosome region, candidate 3 (non-protein coding)
chr11_+_124481451 0.275 NM_052959
PANX3
pannexin 3
chr5_+_155753755 0.273 NM_000337
NM_001128209
NM_172244
SGCD


sarcoglycan, delta (35kDa dystrophin-associated glycoprotein)


chr10_+_18549583 0.269 NM_000724
CACNB2
calcium channel, voltage-dependent, beta 2 subunit
chr19_-_39235113 0.268 NM_144691
CAPN12
calpain 12
chr18_+_76740274 0.267 NM_171999
SALL3
sal-like 3 (Drosophila)
chr6_-_46293404 0.266 RCAN2
regulator of calcineurin 2
chr7_+_129015483 0.265 NM_001130722
AHCYL2
adenosylhomocysteinase-like 2
chr2_-_37374948 0.261 NM_001135652
EIF2AK2
eukaryotic translation initiation factor 2-alpha kinase 2
chr14_+_32798478 0.260 NM_004274
AKAP6
A kinase (PRKA) anchor protein 6
chr8_-_12612968 0.260 NM_152271
LONRF1
LON peptidase N-terminal domain and ring finger 1
chr12_-_16759430 0.259 LMO3
LIM domain only 3 (rhombotin-like 2)
chr6_+_64231626 0.257 PTP4A1
protein tyrosine phosphatase type IVA, member 1
chr11_+_131240370 0.257 NM_001048209
NTM
neurotrimin

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.42 6.80e-08 GO:0032501 multicellular organismal process
2.14 7.17e-06 GO:0050793 regulation of developmental process
1.57 8.30e-06 GO:0048731 system development
2.30 2.45e-05 GO:0045595 regulation of cell differentiation
1.51 2.46e-05 GO:0048856 anatomical structure development
1.48 3.33e-05 GO:0007275 multicellular organismal development
1.45 3.72e-05 GO:0032502 developmental process
1.65 2.60e-04 GO:0048513 organ development
2.12 2.75e-04 GO:2000026 regulation of multicellular organismal development
3.18 2.94e-03 GO:0007517 muscle organ development
1.88 8.37e-03 GO:0009888 tissue development
2.28 9.48e-03 GO:0051094 positive regulation of developmental process
2.67 9.53e-03 GO:0061061 muscle structure development
1.58 1.05e-02 GO:0003008 system process
2.22 1.20e-02 GO:0045944 positive regulation of transcription from RNA polymerase II promoter
1.63 1.47e-02 GO:0007399 nervous system development
21.28 1.71e-02 GO:0060501 positive regulation of epithelial cell proliferation involved in lung morphogenesis
2.44 3.25e-02 GO:0060284 regulation of cell development
2.61 3.28e-02 GO:0045596 negative regulation of cell differentiation
1.75 3.88e-02 GO:0006357 regulation of transcription from RNA polymerase II promoter
1.63 4.81e-02 GO:0051239 regulation of multicellular organismal process

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
4.22 2.90e-03 GO:0045095 keratin filament
1.42 3.67e-02 GO:0005576 extracellular region

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.75 5.83e-03 GO:0001071 nucleic acid binding transcription factor activity
1.75 5.83e-03 GO:0003700 sequence-specific DNA binding transcription factor activity
3.01 1.20e-02 GO:0008083 growth factor activity
1.86 1.82e-02 GO:0043565 sequence-specific DNA binding