Motif ID: NFE2L1.p2

Z-value: 1.196


Transcription factors associated with NFE2L1.p2:

Gene SymbolEntrez IDGene Name
NFE2L1 4779 nuclear factor (erythroid-derived 2)-like 1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.p-valuePlot
NFE2L1chr17_+_461257250.262.1e-01Click!


Activity profile for motif NFE2L1.p2.

activity profile for motif NFE2L1.p2


Sorted Z-values histogram for motif NFE2L1.p2

Sorted Z-values for motif NFE2L1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NFE2L1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr4_+_74606222 4.041 NM_000584
IL8
interleukin 8
chr1_+_212738675 2.315 NM_001030287
ATF3
activating transcription factor 3
chr5_-_94417544 1.688 NM_001002796
MCTP1
multiple C2 domains, transmembrane 1
chr13_+_97874704 1.672 MBNL2
muscleblind-like 2 (Drosophila)
chr7_+_65419441 1.662 VKORC1L1
vitamin K epoxide reductase complex, subunit 1-like 1
chr15_+_67418053 1.558 NM_001145102
SMAD3
SMAD family member 3
chr21_+_47545896 1.552 COL6A2
collagen, type VI, alpha 2
chr1_-_173020011 1.510 NM_005092
TNFSF18
tumor necrosis factor (ligand) superfamily, member 18
chr4_-_139163222 1.501 NM_014331
SLC7A11
solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
chr9_-_123688352 1.423 TRAF1
TNF receptor-associated factor 1
chr10_+_35464514 1.362 NM_182769
NM_182770
CREM

cAMP responsive element modulator

chr1_-_169703178 1.353 NM_000450
SELE
selectin E
chr2_+_108994366 1.334 NM_006588
SULT1C4
sulfotransferase family, cytosolic, 1C, member 4
chr2_-_28113954 1.305 LOC100302650
uncharacterized LOC100302650
chr2_-_136873740 1.287 NM_001008540
CXCR4
chemokine (C-X-C motif) receptor 4
chr6_-_10419786 1.248 NM_001042425
TFAP2A
transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
chrX_+_78426468 1.246 NM_032553
GPR174
G protein-coupled receptor 174
chr11_+_6897855 1.214 NM_207186
OR10A4
olfactory receptor, family 10, subfamily A, member 4
chr2_+_46524901 1.211 EPAS1
endothelial PAS domain protein 1
chr2_-_165551178 1.161 COBLL1
COBL-like 1
chr11_+_66384052 1.111 NM_001198845
NM_001198846
NM_001198836
NM_001198837
NM_006328
RBM14-RBM4

RBM14


RBM14-RBM4 readthrough

RNA binding motif protein 14


chr11_-_46717657 1.107 ARHGAP1
Rho GTPase activating protein 1
chr10_+_75673346 1.014 PLAU
plasminogen activator, urokinase
chr11_-_5537815 1.014 NM_145053
UBQLNL
ubiquilin-like
chr13_+_97928196 1.005 MBNL2
muscleblind-like 2 (Drosophila)
chr21_-_35899046 1.005 NM_203418
RCAN1
regulator of calcineurin 1
chr18_-_65182507 0.985 DSEL
dermatan sulfate epimerase-like
chr5_+_139060295 0.973 CXXC5
CXXC finger protein 5
chr12_+_100660846 0.972 SCYL2
SCY1-like 2 (S. cerevisiae)
chr13_+_97928414 0.966 MBNL2
muscleblind-like 2 (Drosophila)
chr1_+_212781969 0.907 NM_001040619
NM_001206484
NM_001206488
NM_001674
ATF3



activating transcription factor 3



chr21_+_34922923 0.902 SON
SON DNA binding protein
chr4_-_159092509 0.873 FAM198B
family with sequence similarity 198, member B
chr11_-_6640645 0.861 TPP1
tripeptidyl peptidase I
chr12_+_50024326 0.847 NM_001031698
PRPF40B
PRP40 pre-mRNA processing factor 40 homolog B (S. cerevisiae)
chr7_-_129592711 0.839 NM_001202498
UBE2H
ubiquitin-conjugating enzyme E2H
chr21_+_47545189 0.828 COL6A2
collagen, type VI, alpha 2
chr12_+_100661158 0.827 SCYL2
SCY1-like 2 (S. cerevisiae)
chr6_-_29395489 0.825 NM_013937
OR11A1
olfactory receptor, family 11, subfamily A, member 1
chr9_-_16727887 0.824 BNC2
basonuclin 2
chr19_+_8455265 0.811 RAB11B
RAB11B, member RAS oncogene family
chr1_-_155939051 0.805 ARHGEF2
Rho/Rac guanine nucleotide exchange factor (GEF) 2
chr1_+_66798095 0.799 PDE4B
phosphodiesterase 4B, cAMP-specific
chr5_-_32388595 0.793 ZFR
zinc finger RNA binding protein
chr14_+_70236266 0.787 SRSF5
serine/arginine-rich splicing factor 5
chr4_-_74964996 0.775 NM_002089
CXCL2
chemokine (C-X-C motif) ligand 2
chr10_-_116444374 0.768 NM_001003407
NM_001003408
ABLIM1

actin binding LIM protein 1

chr6_+_55039070 0.765 NM_001526
HCRTR2
hypocretin (orexin) receptor 2
chr10_+_35484829 0.762 NM_182721
NM_182722
NM_182723
NM_182724
NM_182725
CREM




cAMP responsive element modulator




chr19_+_8455243 0.744 RAB11B
RAB11B, member RAS oncogene family
chr17_-_38938785 0.731 NM_181537
KRT27
keratin 27
chr19_-_55677919 0.730 NM_178837
C19orf51
chromosome 19 open reading frame 51
chr13_+_97874540 0.716 NM_144778
NM_207304
MBNL2

muscleblind-like 2 (Drosophila)

chr11_-_124190092 0.708 NM_001002918
OR8D2
olfactory receptor, family 8, subfamily D, member 2
chr17_-_17399494 0.707 NM_001199989
NM_016084
RASD1

RAS, dexamethasone-induced 1

chr5_+_140753480 0.693 NM_018919
NM_032086
PCDHGA6

protocadherin gamma subfamily A, 6

chr2_+_228336809 0.693 AGFG1
ArfGAP with FG repeats 1
chr5_+_125800786 0.690 NM_001146322
GRAMD3
GRAM domain containing 3
chr10_-_116392099 0.689 ABLIM1
actin binding LIM protein 1
chr5_+_113698304 0.680 KCNN2
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2
chr1_+_114472438 0.668 HIPK1
homeodomain interacting protein kinase 1
chr7_-_129592794 0.656 NM_003344
NM_182697
UBE2H

ubiquitin-conjugating enzyme E2H

chr5_-_95297424 0.655 ELL2
elongation factor, RNA polymerase II, 2
chr1_-_229643996 0.644 NUP133
nucleoporin 133kDa
chr14_-_76447445 0.633 TGFB3
transforming growth factor, beta 3
chr19_+_11200124 0.632 LDLR
low density lipoprotein receptor
chr11_-_8832189 0.630 NM_213618
ST5
suppression of tumorigenicity 5
chr10_+_35456443 0.628 NM_182771
NM_182772
CREM

cAMP responsive element modulator

chr1_+_12040475 0.621 MFN2
mitofusin 2
chr4_+_74735107 0.621 NM_001511
CXCL1
chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
chr2_+_169926084 0.616 DHRS9
dehydrogenase/reductase (SDR family) member 9
chr11_-_7961066 0.615 NM_001003745
OR10A3
olfactory receptor, family 10, subfamily A, member 3
chr5_+_140810181 0.613 PCDHGA12
protocadherin gamma subfamily A, 12
chr15_+_91478498 0.606 UNC45A
unc-45 homolog A (C. elegans)
chr14_+_65007418 0.605 HSPA2
heat shock 70kDa protein 2
chr3_-_50374795 0.601 RASSF1
Ras association (RalGDS/AF-6) domain family member 1
chr14_+_55034329 0.596 NM_001161576
NM_015589
SAMD4A

sterile alpha motif domain containing 4A

chr18_+_580356 0.595 NM_004066
CETN1
centrin, EF-hand protein, 1
chr6_+_142623364 0.592 GPR126
G protein-coupled receptor 126
chr3_+_127771342 0.590


chr19_-_15083729 0.584 NM_005071
SLC1A6
solute carrier family 1 (high affinity aspartate/glutamate transporter), member 6
chr3_-_50374749 0.583 RASSF1
Ras association (RalGDS/AF-6) domain family member 1
chr5_-_115910406 0.581 NM_020796
SEMA6A
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A
chr4_+_41700736 0.581 LIMCH1
LIM and calponin homology domains 1
chr5_+_140810126 0.581 NM_003735
NM_032094
PCDHGA12

protocadherin gamma subfamily A, 12

chr12_+_54891539 0.571 NCKAP1L
NCK-associated protein 1-like
chr7_+_143701021 0.570 NM_001005281
OR6B1
olfactory receptor, family 6, subfamily B, member 1
chr17_-_36981552 0.570 NM_017748
CWC25
CWC25 spliceosome-associated protein homolog (S. cerevisiae)
chr13_+_49684388 0.564 NM_014923
FNDC3A
fibronectin type III domain containing 3A
chr1_-_150241409 0.562 NM_001077628
NM_001243771
NM_001243772
NM_016022
APH1A



anterior pharynx defective 1 homolog A (C. elegans)



chr3_+_127771307 0.560 SEC61A1
Sec61 alpha 1 subunit (S. cerevisiae)
chr7_+_150811719 0.559 AGAP3
ArfGAP with GTPase domain, ankyrin repeat and PH domain 3
chr2_+_239756672 0.558 NM_057179
TWIST2
twist homolog 2 (Drosophila)
chr14_-_55369163 0.553 NM_000161
NM_001024024
NM_001024070
NM_001024071
GCH1



GTP cyclohydrolase 1



chr12_+_100661203 0.553 NM_017988
SCYL2
SCY1-like 2 (S. cerevisiae)
chr10_+_104155431 0.548 NM_002502
NFKB2
nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
chr1_-_935352 0.542 HES4
hairy and enhancer of split 4 (Drosophila)
chr5_+_125758818 0.542 NM_001146320
NM_001146321
NM_023927
GRAMD3


GRAM domain containing 3


chr11_+_43963809 0.541 NM_001145033
C11orf96
chromosome 11 open reading frame 96
chr2_+_220309373 0.538 SPEG
SPEG complex locus
chr9_+_74920329 0.538


chr6_+_89790464 0.537 PNRC1
proline-rich nuclear receptor coactivator 1
chr1_+_110453456 0.536 CSF1
colony stimulating factor 1 (macrophage)
chr15_+_67430358 0.536 NM_001145103
SMAD3
SMAD family member 3
chrX_-_136113832 0.535 NM_054021
GPR101
G protein-coupled receptor 101
chr6_+_89790412 0.533 NM_006813
PNRC1
proline-rich nuclear receptor coactivator 1
chr19_+_13135745 0.531 NFIX
nuclear factor I/X (CCAAT-binding transcription factor)
chr7_-_99527242 0.531 NM_181538
GJC3
gap junction protein, gamma 3, 30.2kDa
chr1_+_212782103 0.524 ATF3
activating transcription factor 3
chr7_-_5568823 0.524 ACTB
actin, beta
chr5_-_32174397 0.521 NM_022130
GOLPH3
golgi phosphoprotein 3 (coat-protein)
chr2_+_16081945 0.520 MYCN
v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)
chr12_+_54891522 0.518 NCKAP1L
NCK-associated protein 1-like
chr11_-_126138789 0.511 SRPR
signal recognition particle receptor (docking protein)
chr14_-_76448091 0.509 NM_003239
TGFB3
transforming growth factor, beta 3
chr1_+_203596222 0.509 ATP2B4
ATPase, Ca++ transporting, plasma membrane 4
chr13_+_48877950 0.509 RB1
retinoblastoma 1
chr5_-_32174385 0.508 GOLPH3
golgi phosphoprotein 3 (coat-protein)
chr12_+_12764844 0.508 CREBL2
cAMP responsive element binding protein-like 2
chr20_+_2944918 0.508 PTPRA
protein tyrosine phosphatase, receptor type, A
chr8_+_23386386 0.508 SLC25A37
solute carrier family 25, member 37
chr17_-_8424217 0.507 MYH10
myosin, heavy chain 10, non-muscle
chr5_+_125759076 0.505 GRAMD3
GRAM domain containing 3
chr12_+_54891491 0.504 NM_005337
NCKAP1L
NCK-associated protein 1-like
chr11_-_6640578 0.504 TPP1
tripeptidyl peptidase I
chr14_+_64682671 0.500 NM_182910
SYNE2
spectrin repeat containing, nuclear envelope 2
chr12_+_104850762 0.499 CHST11
carbohydrate (chondroitin 4) sulfotransferase 11
chr6_-_10412606 0.499 NM_001032280
TFAP2A
transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
chrX_+_152770083 0.495 BGN
biglycan
chr14_+_21945358 0.494 TOX4
TOX high mobility group box family member 4
chr5_+_179132676 0.492 CANX
calnexin
chr10_-_46030798 0.491 NM_001002266
MARCH8
membrane-associated ring finger (C3HC4) 8
chr21_-_43430448 0.491 NM_001098402
NM_001098403
NM_020727
ZNF295


zinc finger protein 295


chr5_-_32174355 0.490 GOLPH3
golgi phosphoprotein 3 (coat-protein)
chr22_-_43089856 0.486 A4GALT
alpha 1,4-galactosyltransferase
chr5_-_32174327 0.485 GOLPH3
golgi phosphoprotein 3 (coat-protein)
chr4_+_38665587 0.484 NM_016531
KLF3
Kruppel-like factor 3 (basic)
chr1_+_155099935 0.480 EFNA1
ephrin-A1
chr22_-_50523780 0.480 NM_139202
MLC1
megalencephalic leukoencephalopathy with subcortical cysts 1
chr5_-_32174242 0.480 GOLPH3
golgi phosphoprotein 3 (coat-protein)
chr10_-_3827205 0.478 KLF6
Kruppel-like factor 6
chr9_-_123689172 0.478 NM_005658
TRAF1
TNF receptor-associated factor 1
chr5_+_140810326 0.477 PCDHGA12
protocadherin gamma subfamily A, 12
chr8_-_37727937 0.473 RAB11FIP1
RAB11 family interacting protein 1 (class I)
chr12_+_104850784 0.472 CHST11
carbohydrate (chondroitin 4) sulfotransferase 11
chr12_+_104850986 0.470 CHST11
carbohydrate (chondroitin 4) sulfotransferase 11
chr19_+_11200146 0.465 LDLR
low density lipoprotein receptor
chr15_+_89182038 0.464 NM_002201
ISG20
interferon stimulated exonuclease gene 20kDa
chr2_-_192711651 0.462 SDPR
serum deprivation response
chr12_-_9268513 0.461 A2M
alpha-2-macroglobulin
chr4_+_153457407 0.458 DKFZP434I0714
uncharacterized protein DKFZP434I0714
chr8_+_42995628 0.458 HGSNAT
heparan-alpha-glucosaminide N-acetyltransferase
chr5_-_16742336 0.457 MYO10
myosin X
chr22_-_50523737 0.457 MLC1
megalencephalic leukoencephalopathy with subcortical cysts 1
chrX_-_48900752 0.454 TFE3
transcription factor binding to IGHM enhancer 3
chr3_-_50374875 0.452 NM_170713
RASSF1
Ras association (RalGDS/AF-6) domain family member 1
chr5_-_54281345 0.452 NM_001135604
NM_007036
ESM1

endothelial cell-specific molecule 1

chr1_+_110453232 0.452 NM_000757
NM_172210
NM_172212
CSF1


colony stimulating factor 1 (macrophage)


chr2_+_202004997 0.452 NM_001202515
CFLAR
CASP8 and FADD-like apoptosis regulator
chr2_+_135676409 0.451 CCNT2
cyclin T2
chr4_-_74904329 0.447 NM_002090
CXCL3
chemokine (C-X-C motif) ligand 3
chr5_-_94417185 0.447 MCTP1
multiple C2 domains, transmembrane 1
chr9_-_73736513 0.445 NM_001007471
TRPM3
transient receptor potential cation channel, subfamily M, member 3
chr6_-_110501164 0.444 NM_001024934
NM_001024935
NM_001024936
NM_003931
WASF1



WAS protein family, member 1



chr2_-_25536762 0.442 DNMT3A
DNA (cytosine-5-)-methyltransferase 3 alpha
chr1_-_182354649 0.442 GLUL
glutamate-ammonia ligase
chr4_-_159094163 0.441 NM_001031700
NM_001128424
FAM198B

family with sequence similarity 198, member B

chr8_+_17104384 0.440 NM_001145152
NM_152415
VPS37A

vacuolar protein sorting 37 homolog A (S. cerevisiae)

chr17_+_57642885 0.439 NM_001166301
NM_024612
DHX40

DEAH (Asp-Glu-Ala-His) box polypeptide 40

chr10_-_116444112 0.437 ABLIM1
actin binding LIM protein 1
chr5_+_140729723 0.436 NM_018922
NM_032095
PCDHGB1

protocadherin gamma subfamily B, 1

chr1_+_84630575 0.436 NM_001242860
NM_001242861
PRKACB

protein kinase, cAMP-dependent, catalytic, beta

chr8_-_145018904 0.435 NM_201381
PLEC
plectin
chr2_+_210444154 0.434 MAP2
microtubule-associated protein 2
chr19_-_1020995 0.433 C19orf6
chromosome 19 open reading frame 6
chr10_-_75335415 0.432 NM_152586
USP54
ubiquitin specific peptidase 54
chr5_+_132209354 0.432 NM_052971
LEAP2
liver expressed antimicrobial peptide 2
chr11_-_64646053 0.431 NM_006795
EHD1
EH-domain containing 1
chr6_+_160183510 0.431 ACAT2
acetyl-CoA acetyltransferase 2
chr1_-_173176314 0.429 NM_003326
TNFSF4
tumor necrosis factor (ligand) superfamily, member 4
chr14_-_35344852 0.428 NM_013448
NM_182648
BAZ1A

bromodomain adjacent to zinc finger domain, 1A

chr2_-_27579626 0.425 GTF3C2
general transcription factor IIIC, polypeptide 2, beta 110kDa
chr22_+_42229105 0.425 NM_004599
SREBF2
sterol regulatory element binding transcription factor 2
chr8_-_104427319 0.424 SLC25A32
solute carrier family 25, member 32
chr14_-_103988829 0.423 CKB
creatine kinase, brain
chr1_-_27240430 0.421 NM_021969
NR0B2
nuclear receptor subfamily 0, group B, member 2
chr6_+_44195008 0.420 SLC29A1
solute carrier family 29 (nucleoside transporters), member 1
chrX_-_62974341 0.420 ARHGEF9
Cdc42 guanine nucleotide exchange factor (GEF) 9
chr14_-_88459459 0.419 GALC
galactosylceramidase
chr4_-_111563278 0.419 NM_001204397
NM_001204398
NM_001204399
NM_153426
NM_153427
PITX2




paired-like homeodomain 2




chr17_-_39623476 0.417 NM_002278
KRT32
keratin 32
chr12_-_9268440 0.417 A2M
alpha-2-macroglobulin
chr12_-_9268522 0.416 NM_000014
A2M
alpha-2-macroglobulin
chr10_+_104154228 0.415 NM_001077493
NM_001077494
NFKB2

nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)

chr5_+_139060058 0.413 CXXC5
CXXC finger protein 5
chr1_+_50574601 0.413 ELAVL4
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)
chr6_+_43445304 0.411 TJAP1
tight junction associated protein 1 (peripheral)
chr2_-_64881040 0.411 NM_014755
SERTAD2
SERTA domain containing 2
chr17_+_38119225 0.410 NM_178171
GSDMA
gasdermin A
chr4_-_16900028 0.410 LDB2
LIM domain binding 2

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.10 1.08e-10 GO:0009987 cellular process
1.12 1.78e-06 GO:0065007 biological regulation
1.49 3.10e-06 GO:0009611 response to wounding
1.17 3.61e-06 GO:0032501 multicellular organismal process
1.61 5.13e-06 GO:0042060 wound healing
1.29 1.05e-05 GO:0065008 regulation of biological quality
1.12 1.61e-05 GO:0050789 regulation of biological process
1.20 2.80e-05 GO:0023052 signaling
1.14 5.66e-05 GO:0050896 response to stimulus
1.12 9.68e-05 GO:0050794 regulation of cellular process
1.20 1.04e-04 GO:0007165 signal transduction
1.59 2.30e-04 GO:0007596 blood coagulation
1.59 2.30e-04 GO:0050817 coagulation
1.58 3.40e-04 GO:0007599 hemostasis
1.17 4.61e-04 GO:0051716 cellular response to stimulus
1.22 1.21e-03 GO:0048518 positive regulation of biological process
1.19 1.34e-03 GO:0048856 anatomical structure development
1.22 2.19e-03 GO:0006950 response to stress
1.22 2.30e-03 GO:0048522 positive regulation of cellular process
1.17 2.78e-03 GO:0032502 developmental process
1.22 3.16e-03 GO:0048519 negative regulation of biological process
1.18 4.21e-03 GO:0007275 multicellular organismal development
1.20 5.24e-03 GO:0048731 system development
1.48 6.26e-03 GO:0050878 regulation of body fluid levels
1.51 9.13e-03 GO:0001775 cell activation
1.65 1.22e-02 GO:0016337 cell-cell adhesion

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.16 8.36e-05 GO:0071944 cell periphery
1.16 1.16e-04 GO:0005886 plasma membrane
1.23 2.62e-04 GO:0044459 plasma membrane part
1.42 3.04e-04 GO:0031410 cytoplasmic vesicle
1.41 4.20e-04 GO:0031982 vesicle
1.38 6.53e-04 GO:0042995 cell projection
1.41 1.03e-03 GO:0016023 cytoplasmic membrane-bounded vesicle
1.40 1.32e-03 GO:0031988 membrane-bounded vesicle
1.08 1.47e-03 GO:0005737 cytoplasm
1.08 1.25e-02 GO:0016020 membrane
1.57 1.67e-02 GO:0015629 actin cytoskeleton
1.46 4.30e-02 GO:0043005 neuron projection

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.13 4.97e-07 GO:0005515 protein binding
1.41 3.03e-02 GO:0008092 cytoskeletal protein binding
1.34 4.31e-02 GO:0015075 ion transmembrane transporter activity
1.53 4.77e-02 GO:0003779 actin binding
1.55 4.98e-02 GO:0016879 ligase activity, forming carbon-nitrogen bonds