Motif ID: NKX2-1,4.p2

Z-value: 0.436


Transcription factors associated with NKX2-1,4.p2:

Gene SymbolEntrez IDGene Name
NKX2-1 7080 NK2 homeobox 1
NKX2-4 644524 NK2 homeobox 4

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.p-valuePlot
NKX2-1chr14_-_369893330.213.2e-01Click!


Activity profile for motif NKX2-1,4.p2.

activity profile for motif NKX2-1,4.p2


Sorted Z-values histogram for motif NKX2-1,4.p2

Sorted Z-values for motif NKX2-1,4.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NKX2-1,4.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr2_+_28616346 1.036 FOSL2
FOS-like antigen 2
chr1_+_84609941 1.004 NM_182948
PRKACB
protein kinase, cAMP-dependent, catalytic, beta
chr2_+_28615695 0.939 FOSL2
FOS-like antigen 2
chr5_-_88119604 0.935 NM_001193348
NM_001193349
MEF2C

myocyte enhancer factor 2C

chr19_+_39155209 0.928


chr2_+_28616360 0.870 FOSL2
FOS-like antigen 2
chr2_+_28615771 0.803 NM_005253
FOSL2
FOS-like antigen 2
chr1_+_61869699 0.797 NFIA
nuclear factor I/A
chr2_+_28615668 0.765 FOSL2
FOS-like antigen 2
chr12_-_7848324 0.733 NM_020634
GDF3
growth differentiation factor 3
chr1_+_212475147 0.692 NM_001199756
PPP2R5A
protein phosphatase 2, regulatory subunit B', alpha
chr8_-_93115453 0.608 NM_001198633
NM_175634
RUNX1T1

runt-related transcription factor 1; translocated to, 1 (cyclin D-related)

chr14_+_64682671 0.577 NM_182910
SYNE2
spectrin repeat containing, nuclear envelope 2
chr5_-_111091947 0.543 NM_001142483
C5orf13
chromosome 5 open reading frame 13
chr9_+_115631814 0.426 SNX30
sorting nexin family member 30
chr10_-_116392099 0.383 ABLIM1
actin binding LIM protein 1
chr1_+_228395740 0.338 NM_001098623
NM_052843
OBSCN

obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF

chr12_+_53442732 0.324 NM_015319
TENC1
tensin like C1 domain containing phosphatase (tensin 2)
chr5_+_32173481 0.304 LOC153546
uncharacterized LOC153546
chr3_+_190105660 0.294 NM_006580
CLDN16
claudin 16
chr2_+_161993465 0.285 NM_004180
NM_133484
TANK

TRAF family member-associated NFKB activator

chrX_+_54947228 0.276 NM_001039705
NM_016157
NM_177556
TRO


trophinin


chr1_+_84764048 0.252 NM_001010971
SAMD13
sterile alpha motif domain containing 13
chr12_-_9268513 0.247 A2M
alpha-2-macroglobulin
chr9_+_127119114 0.245


chr3_-_18480203 0.243 NM_001131010
SATB1
SATB homeobox 1
chr2_+_33701320 0.240 NM_001139488
RASGRP3
RAS guanyl releasing protein 3 (calcium and DAG-regulated)
chr8_+_7705401 0.235 NM_058203
NM_001081552
SPAG11B
SPAG11A
sperm associated antigen 11B
sperm associated antigen 11A
chr19_-_40440532 0.230 NM_003890
FCGBP
Fc fragment of IgG binding protein
chrX_-_117251302 0.225 NM_001168301
KLHL13
kelch-like 13 (Drosophila)
chr12_+_79258588 0.222 SYT1
synaptotagmin I
chr3_-_47621729 0.216 NM_001206942
NM_001206945
CSPG5

chondroitin sulfate proteoglycan 5 (neuroglycan C)

chr5_-_88199868 0.216 NM_001131005
NM_001193347
MEF2C

myocyte enhancer factor 2C

chr19_-_6670598 0.215 NM_003807
NM_172014
TNFSF14

tumor necrosis factor (ligand) superfamily, member 14

chr4_+_86749045 0.200 ARHGAP24
Rho GTPase activating protein 24
chr2_+_38155901 0.199 NM_001170792
FAM82A1
family with sequence similarity 82, member A1
chr9_-_124984018 0.193 NM_001242335
LHX6
LIM homeobox 6
chr4_+_74606222 0.191 NM_000584
IL8
interleukin 8
chr12_+_79258448 0.188 NM_005639
SYT1
synaptotagmin I
chr2_+_179184970 0.184 NM_145739
OSBPL6
oxysterol binding protein-like 6
chr18_+_6834431 0.183 NM_001010000
ARHGAP28
Rho GTPase activating protein 28
chr4_-_186732208 0.183 NM_001145671
SORBS2
sorbin and SH3 domain containing 2
chr12_-_12503135 0.181 NM_018050
MANSC1
MANSC domain containing 1
chr11_-_102826433 0.180 NM_002427
MMP13
matrix metallopeptidase 13 (collagenase 3)
chr3_-_141747434 0.179 NM_001178141
NM_001178142
NM_006286
TFDP2


transcription factor Dp-2 (E2F dimerization partner 2)


chr17_-_66951381 0.176 NM_007168
ABCA8
ATP-binding cassette, sub-family A (ABC1), member 8
chr3_-_126327397 0.176 NM_001039783
TXNRD3NB
thioredoxin reductase 3 neighbor
chr15_-_31947541 0.172 NM_130901
OTUD7A
OTU domain containing 7A
chr2_-_188419185 0.171 NM_001032281
NM_006287
TFPI

tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)

chr17_+_67498391 0.169 MAP2K6
mitogen-activated protein kinase kinase 6
chr4_-_104020964 0.165 NM_020139
BDH2
3-hydroxybutyrate dehydrogenase, type 2
chr17_-_7493389 0.165 NM_006942
SOX15
SRY (sex determining region Y)-box 15
chr20_+_33462765 0.163 NM_001242393
ACSS2
acyl-CoA synthetase short-chain family member 2
chrX_+_69454504 0.157 NM_001013579
AWAT1
acyl-CoA wax alcohol acyltransferase 1
chr9_+_124048869 0.155 GSN
gelsolin
chr10_+_35484054 0.152 NM_182717
NM_182718
NM_182719
NM_182720
CREM



cAMP responsive element modulator



chr17_+_7905911 0.150 NM_000180
GUCY2D
guanylate cyclase 2D, membrane (retina-specific)
chr10_+_94594469 0.150 NM_001013848
EXOC6
exocyst complex component 6
chr17_-_35656691 0.146 NM_198837
NM_198838
ACACA

acetyl-CoA carboxylase alpha

chr1_-_45477016 0.145 NM_024602
HECTD3
HECT domain containing 3
chr8_-_93107442 0.143 NM_001198629
NM_001198630
NM_001198632
NM_175635
RUNX1T1



runt-related transcription factor 1; translocated to, 1 (cyclin D-related)



chr11_+_6897855 0.141 NM_207186
OR10A4
olfactory receptor, family 10, subfamily A, member 4
chrX_-_33229428 0.132 NM_004006
DMD
dystrophin
chr11_-_6643809 0.130 DCHS1
dachsous 1 (Drosophila)
chr17_+_61086897 0.130 NM_025185
TANC2
tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2
chr1_-_21377452 0.130 EIF4G3
eukaryotic translation initiation factor 4 gamma, 3
chr12_+_15699277 0.128 NM_030668
NM_030669
NM_030670
NM_030671
PTPRO



protein tyrosine phosphatase, receptor type, O



chr1_+_41204509 0.128 NFYC
nuclear transcription factor Y, gamma
chr6_+_30951484 0.127 NM_001010909
MUC21
mucin 21, cell surface associated
chrX_+_49593905 0.126 NM_007003
PAGE4
P antigen family, member 4 (prostate associated)
chr9_-_33395265 0.120 AQP7
aquaporin 7
chr16_-_49860917 0.117 NM_015069
ZNF423
zinc finger protein 423
chr2_+_46524448 0.117 NM_001430
EPAS1
endothelial PAS domain protein 1
chr12_-_9268475 0.116 A2M
alpha-2-macroglobulin
chr2_-_133539627 0.116 NCKAP5
NCK-associated protein 5
chr3_-_185270258 0.116 NM_139248
LIPH
lipase, member H
chr2_-_191184770 0.112 NM_014362
NM_198047
HIBCH

3-hydroxyisobutyryl-CoA hydrolase

chr17_-_5138049 0.112 NM_207103
SCIMP
SLP adaptor and CSK interacting membrane protein
chr1_+_153232178 0.111 NM_000427
LOR
loricrin
chrX_+_78200828 0.111 NM_014499
NM_198333
P2RY10

purinergic receptor P2Y, G-protein coupled, 10

chr2_-_192015751 0.110 STAT4
signal transducer and activator of transcription 4
chr1_-_110155672 0.109 NM_005272
GNAT2
guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2
chr4_+_130017281 0.107 NM_001099783
C4orf33
chromosome 4 open reading frame 33
chr1_-_21437875 0.107 NM_003760
EIF4G3
eukaryotic translation initiation factor 4 gamma, 3
chr2_-_192015733 0.103 STAT4
signal transducer and activator of transcription 4
chr11_+_56949220 0.100 NM_001005210
LRRC55
leucine rich repeat containing 55
chr16_+_3062456 0.099 NM_020982
CLDN9
claudin 9
chr11_+_58390145 0.098 NM_000614
CNTF
ciliary neurotrophic factor
chr12_+_12878718 0.097 NM_001130415
APOLD1
apolipoprotein L domain containing 1
chr22_-_36019363 0.093 NM_203377
MB
myoglobin
chr13_+_111839172 0.092 NM_001113513
ARHGEF7
Rho guanine nucleotide exchange factor (GEF) 7
chr18_-_53068755 0.088 TCF4
transcription factor 4
chr12_-_75603510 0.087 NM_139136
NM_139137
NM_153748
KCNC2


potassium voltage-gated channel, Shaw-related subfamily, member 2


chr15_+_40650411 0.086 NM_033510
DISP2
dispatched homolog 2 (Drosophila)
chr20_+_31823801 0.086 NM_001243193
NM_016583
NM_130852
BPIFA1


BPI fold containing family A, member 1


chr12_+_50451486 0.085 NM_001095
NM_020039
ACCN2

amiloride-sensitive cation channel 2, neuronal

chr3_-_17782398 0.085 NM_014744
TBC1D5
TBC1 domain family, member 5
chr19_-_10291056 0.084


chr2_-_242556883 0.084 NM_001164356
THAP4
THAP domain containing 4
chr13_-_75901897 0.084 TBC1D4
TBC1 domain family, member 4
chr13_-_48987652 0.082 NM_001162498
LPAR6
lysophosphatidic acid receptor 6
chr11_+_844445 0.081 NM_001025237
TSPAN4
tetraspanin 4
chr3_+_46919235 0.080 NM_000316
PTH1R
parathyroid hormone 1 receptor
chr1_-_62191094 0.080 NM_032027
TM2D1
TM2 domain containing 1
chr22_+_33196801 0.078 NM_000362
TIMP3
TIMP metallopeptidase inhibitor 3
chr5_+_175298604 0.077 CPLX2
complexin 2
chr16_+_570731 0.077


chr3_+_158991035 0.076 NM_001197107
NM_001197108
NM_014575
SCHIP1


schwannomin interacting protein 1


chr2_-_50574891 0.076 NM_138735
NRXN1
neurexin 1
chr19_+_36726883 0.076 ZNF146
zinc finger protein 146
chr3_-_114102488 0.076 NM_001164342
ZBTB20
zinc finger and BTB domain containing 20
chr2_-_192015934 0.075 NM_003151
STAT4
signal transducer and activator of transcription 4
chr1_+_196788860 0.074 NM_002113
CFHR1
complement factor H-related 1
chr7_-_7758237 0.073 NM_002947
RPA3
replication protein A3, 14kDa
chr2_-_192016293 0.073 NM_001243835
STAT4
signal transducer and activator of transcription 4
chr9_+_116207010 0.073 NM_144488
RGS3
regulator of G-protein signaling 3
chr17_-_63822660 0.072 NM_001037325
CEP112
centrosomal protein 112kDa
chr3_+_16216155 0.072 NM_054110
GALNTL2
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase-like 2
chr11_-_66675334 0.070 NM_022172
PC
pyruvate carboxylase
chr5_+_140800613 0.070 PCDHGA11
protocadherin gamma subfamily A, 11
chr1_+_45478420 0.070 UROD
uroporphyrinogen decarboxylase
chr2_+_1418179 0.070 NM_175721
NM_175722
TPO

thyroid peroxidase

chrX_-_117119282 0.069 NM_001168299
KLHL13
kelch-like 13 (Drosophila)
chr1_-_226926875 0.068 NM_002221
ITPKB
inositol-trisphosphate 3-kinase B
chr3_-_112359863 0.068 CCDC80
coiled-coil domain containing 80
chr5_-_35118223 0.067 NM_001204314
NM_001204315
NM_001204316
NM_001204317
NM_001204318
PRLR




prolactin receptor




chr1_-_33813261 0.067


chr15_-_83474805 0.066 NM_001007122
FSD2
fibronectin type III and SPRY domain containing 2
chr11_+_64018991 0.066 NM_000932
NM_001184883
PLCB3

phospholipase C, beta 3 (phosphatidylinositol-specific)

chr5_-_134782797 0.066 NM_130848
C5orf20
chromosome 5 open reading frame 20
chr2_-_188419049 0.066 TFPI
tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
chr19_-_16045669 0.065 NM_001128932
NM_021187
CYP4F11

cytochrome P450, family 4, subfamily F, polypeptide 11

chr6_+_153019029 0.063 NM_025107
MYCT1
myc target 1
chrX_+_70765479 0.063 OGT
O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase)
chr17_+_35849997 0.062 DUSP14
dual specificity phosphatase 14
chr12_+_25205488 0.062 LRMP
lymphoid-restricted membrane protein
chr6_+_5261212 0.062 FARS2
phenylalanyl-tRNA synthetase 2, mitochondrial
chr9_+_131446105 0.061 SET
SET nuclear oncogene
chr12_+_29376596 0.061 NM_018099
FAR2
fatty acyl CoA reductase 2
chr9_+_124048396 0.060 GSN
gelsolin
chr2_+_169929009 0.060 NM_001142270
DHRS9
dehydrogenase/reductase (SDR family) member 9
chr6_+_31674639 0.059 NM_001003693
LY6G6F
lymphocyte antigen 6 complex, locus G6F
chr7_-_37024664 0.058 NM_001039459
ELMO1
engulfment and cell motility 1
chr6_+_108616059 0.058 NM_145315
LACE1
lactation elevated 1
chrX_-_109561427 0.058 AMMECR1
Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1
chr2_+_1417232 0.057 NM_000547
NM_001206744
NM_001206745
NM_175719
TPO



thyroid peroxidase



chr7_+_94297448 0.056 PEG10
paternally expressed 10
chr3_+_113616317 0.056 NM_001172105
GRAMD1C
GRAM domain containing 1C
chr2_-_192015706 0.056 STAT4
signal transducer and activator of transcription 4
chr3_-_48671278 0.055 NM_001040454
SLC26A6
solute carrier family 26, member 6
chr6_-_11111955 0.055 NM_207582
ERVFRD-1
endogenous retrovirus group FRD, member 1
chr12_-_49177876 0.054 NM_015270
ADCY6
adenylate cyclase 6
chr1_+_226012974 0.054 NM_000120
EPHX1
epoxide hydrolase 1, microsomal (xenobiotic)
chr19_-_11688508 0.053 NM_001611
ACP5
acid phosphatase 5, tartrate resistant
chr6_+_43266008 0.052 SLC22A7
solute carrier family 22 (organic anion transporter), member 7
chr18_+_3447607 0.052 NM_173207
TGIF1
TGFB-induced factor homeobox 1
chr3_-_51996855 0.050 NM_033010
PCBP4
poly(rC) binding protein 4
chr15_+_77287428 0.050 NM_003978
PSTPIP1
proline-serine-threonine phosphatase interacting protein 1
chr11_+_65266642 0.049


chr15_+_80364902 0.049 NM_001242915
NM_001242916
ZFAND6

zinc finger, AN1-type domain 6

chr14_+_39703119 0.049 NM_054024
MIA2
melanoma inhibitory activity 2
chr8_-_7321028 0.049 NM_016512
NM_058200
NM_058201
NM_058202
NM_058203
SPAG11B




sperm associated antigen 11B




chr6_-_3272349 0.048 SLC22A23
solute carrier family 22, member 23
chr1_-_231560789 0.047 NM_022051
EGLN1
egl nine homolog 1 (C. elegans)
chr12_-_102591547 0.047 NM_002674
PMCH
pro-melanin-concentrating hormone
chr11_+_118754474 0.046 NM_001716
CXCR5
chemokine (C-X-C motif) receptor 5
chr17_-_53800074 0.046 NM_018286
TMEM100
transmembrane protein 100
chr11_+_1213469 0.045 MUC5AC
mucin 5AC, oligomeric mucus/gel-forming
chr22_-_38881529 0.045 DDX17
DEAD (Asp-Glu-Ala-Asp) box polypeptide 17
chr7_+_129847699 0.045 NM_145268
C7orf45
chromosome 7 open reading frame 45
chr2_-_209054772 0.044 NM_001099334
C2orf80
chromosome 2 open reading frame 80
chr1_-_45476967 0.044 HECTD3
HECT domain containing 3
chr1_-_179112178 0.044 NM_001136000
NM_001168239
NM_005158
ABL2


v-abl Abelson murine leukemia viral oncogene homolog 2


chr2_-_166650770 0.044 NM_004482
GALNT3
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 3 (GalNAc-T3)
chr14_+_24782312 0.043 NM_181657
LTB4R
leukotriene B4 receptor
chr3_-_112359660 0.043 CCDC80
coiled-coil domain containing 80
chr1_+_212797788 0.042 NM_153606
FAM71A
family with sequence similarity 71, member A
chr1_-_9129620 0.042 SLC2A5
solute carrier family 2 (facilitated glucose/fructose transporter), member 5
chr19_+_34663311 0.041 NM_001114093
NM_015578
LSM14A

LSM14A, SCD6 homolog A (S. cerevisiae)

chr3_-_74570262 0.041 NM_020872
CNTN3
contactin 3 (plasmacytoma associated)
chr20_-_34243118 0.041 RBM12
RNA binding motif protein 12
chr10_-_65225605 0.041 NM_032776
JMJD1C
jumonji domain containing 1C
chr19_-_45996470 0.041 NM_206901
RTN2
reticulon 2
chr1_+_101003692 0.041 NM_022049
GPR88
G protein-coupled receptor 88
chr9_+_90341123 0.040 CTSL1
cathepsin L1
chr1_-_156460390 0.040 MEF2D
myocyte enhancer factor 2D
chr5_+_140800536 0.039 NM_018914
NM_032091
NM_032092
PCDHGA11


protocadherin gamma subfamily A, 11


chr4_-_69111333 0.039 NM_182502
TMPRSS11B
transmembrane protease, serine 11B
chr1_-_203320287 0.039 NM_002023
FMOD
fibromodulin
chr10_-_11574273 0.039 NM_001080491
USP6NL
USP6 N-terminal like
chr22_-_29457793 0.038 NM_015370
C22orf31
chromosome 22 open reading frame 31
chr4_+_70861647 0.038 NM_001009181
NM_003154
STATH

statherin

chr20_-_17539480 0.038 NM_001161705
BFSP1
beaded filament structural protein 1, filensin
chr12_-_113658826 0.038 NM_138451
IQCD
IQ motif containing D
chr1_-_33841142 0.038 NM_198040
PHC2
polyhomeotic homolog 2 (Drosophila)
chr1_-_21377387 0.038 EIF4G3
eukaryotic translation initiation factor 4 gamma, 3
chr16_+_76343734 0.038 NM_138994
CNTNAP4
contactin associated protein-like 4
chr7_+_94539209 0.038 NM_001166161
NM_001166162
NM_001166163
PPP1R9A


protein phosphatase 1, regulatory subunit 9A


chr7_-_104909442 0.037 NM_182691
SRPK2
SRSF protein kinase 2
chr3_+_119501556 0.037 NM_022002
NR1I2
nuclear receptor subfamily 1, group I, member 2

Gene Ontology Analysis

Nothing significant found in process category.

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
3.15 2.12e-02 GO:0005792 microsome
3.05 3.08e-02 GO:0042598 vesicular fraction
1.60 3.09e-02 GO:0005576 extracellular region

Nothing significant found in function category.