Motif ID: NKX2-2,8.p2

Z-value: 0.897


Transcription factors associated with NKX2-2,8.p2:

Gene SymbolEntrez IDGene Name
NKX2-2 4821 NK2 homeobox 2
NKX2-8 26257 NK2 homeobox 8

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.p-valuePlot
NKX2-8chr14_-_370517850.096.8e-01Click!
NKX2-2chr20_-_21494663-0.009.9e-01Click!


Activity profile for motif NKX2-2,8.p2.

activity profile for motif NKX2-2,8.p2


Sorted Z-values histogram for motif NKX2-2,8.p2

Sorted Z-values for motif NKX2-2,8.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NKX2-2,8.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr12_+_20724797 1.969 NM_001244683
PDE3A
phosphodiesterase 3A, cGMP-inhibited
chr1_+_84630014 1.892 NM_001242857
NM_001242858
NM_001242859
PRKACB


protein kinase, cAMP-dependent, catalytic, beta


chr9_-_14086901 1.703 NFIB
nuclear factor I/B
chr17_-_67138013 1.642 NM_080284
ABCA6
ATP-binding cassette, sub-family A (ABC1), member 6
chr4_+_41614933 1.633 LIMCH1
LIM and calponin homology domains 1
chr4_+_41614911 1.621 NM_001112719
NM_001112720
LIMCH1

LIM and calponin homology domains 1

chr11_+_65271145 1.350


chr1_+_84630374 1.331 PRKACB
protein kinase, cAMP-dependent, catalytic, beta
chr11_+_65266642 1.243


chr1_+_61869699 1.199 NFIA
nuclear factor I/A
chr4_+_41700736 1.180 LIMCH1
LIM and calponin homology domains 1
chr3_+_132316080 1.180 NM_016557
CCRL1
chemokine (C-C motif) receptor-like 1
chr13_-_41556188 1.168 ELF1
E74-like factor 1 (ets domain transcription factor)
chr2_+_173686314 1.097 NM_001100397
RAPGEF4
Rap guanine nucleotide exchange factor (GEF) 4
chr11_+_12960793 1.086 TEAD1
TEA domain family member 1 (SV40 transcriptional enhancer factor)
chr1_+_203596222 1.011 ATP2B4
ATPase, Ca++ transporting, plasma membrane 4
chr3_-_15839674 1.010 NM_001195098
ANKRD28
ankyrin repeat domain 28
chr10_+_35456443 0.933 NM_182771
NM_182772
CREM

cAMP responsive element modulator

chr4_+_41614725 0.924 LIMCH1
LIM and calponin homology domains 1
chr14_-_100841656 0.916 WARS
tryptophanyl-tRNA synthetase
chr12_-_10021932 0.901 CLEC2B
C-type lectin domain family 2, member B
chr7_+_37723378 0.865


chr14_+_65877309 0.855 NM_004480
NM_178155
NM_178156
FUT8


fucosyltransferase 8 (alpha (1,6) fucosyltransferase)


chr4_-_110723334 0.840 NM_000204
CFI
complement factor I
chr17_-_66951381 0.804 NM_007168
ABCA8
ATP-binding cassette, sub-family A (ABC1), member 8
chr13_+_111855406 0.767 ARHGEF7
Rho guanine nucleotide exchange factor (GEF) 7
chr11_+_118175294 0.767 NM_000733
CD3E
CD3e molecule, epsilon (CD3-TCR complex)
chr2_-_191872322 0.759 STAT1
signal transducer and activator of transcription 1, 91kDa
chr10_+_63808968 0.748 NM_001244638
ARID5B
AT rich interactive domain 5B (MRF1-like)
chr4_+_95376396 0.717 PDLIM5
PDZ and LIM domain 5
chr12_-_102591547 0.706 NM_002674
PMCH
pro-melanin-concentrating hormone
chr10_+_35484054 0.687 NM_182717
NM_182718
NM_182719
NM_182720
CREM



cAMP responsive element modulator



chr9_-_10612722 0.671 NM_002839
PTPRD
protein tyrosine phosphatase, receptor type, D
chr3_-_18480203 0.670 NM_001131010
SATB1
SATB homeobox 1
chr19_+_39155209 0.653


chr8_-_80993009 0.651 NM_001025252
TPD52
tumor protein D52
chr9_+_115631814 0.649 SNX30
sorting nexin family member 30
chr11_+_33563772 0.646 NM_012194
C11orf41
chromosome 11 open reading frame 41
chr1_-_244006885 0.632 NM_001206729
AKT3
v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma)
chr16_-_31228394 0.631 NM_152901
PYDC1
PYD (pyrin domain) containing 1
chr8_-_17555158 0.626 NM_020749
MTUS1
microtubule associated tumor suppressor 1
chr17_+_3377346 0.622 NM_001128085
ASPA
aspartoacylase
chr4_+_87928083 0.612 NM_005935
AFF1
AF4/FMR2 family, member 1
chr7_+_104681378 0.609 MLL5
myeloid/lymphoid or mixed-lineage leukemia 5 (trithorax homolog, Drosophila)
chr2_-_216300444 0.600 FN1
fibronectin 1
chr6_+_155411422 0.600 NM_012454
TIAM2
T-cell lymphoma invasion and metastasis 2
chrX_+_66788682 0.596 NM_001011645
AR
androgen receptor
chr3_+_158991035 0.594 NM_001197107
NM_001197108
NM_014575
SCHIP1


schwannomin interacting protein 1


chr15_+_25281105 0.583 SNRPN
small nuclear ribonucleoprotein polypeptide N
chr2_-_183387063 0.582 NM_005019
NM_001003683
PDE1A

phosphodiesterase 1A, calmodulin-dependent

chr7_+_115863004 0.580 NM_152829
TES
testis derived transcript (3 LIM domains)
chr10_+_5136613 0.580 AKR1C3
aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II)
chr4_-_186697065 0.578 NM_001145673
SORBS2
sorbin and SH3 domain containing 2
chr13_-_20357125 0.549 NM_001042414
PSPC1
paraspeckle component 1
chr9_+_79056581 0.543 NM_001097634
GCNT1
glucosaminyl (N-acetyl) transferase 1, core 2
chr4_-_110723127 0.539 CFI
complement factor I
chr12_-_56563964 0.531 SMARCC2
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2
chr13_-_78493902 0.518 NM_001201397
EDNRB
endothelin receptor type B
chr3_-_150966901 0.508 NM_001081455
P2RY14
purinergic receptor P2Y, G-protein coupled, 14
chr1_-_110155672 0.501 NM_005272
GNAT2
guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2
chr3_-_112359251 0.495 CCDC80
coiled-coil domain containing 80
chr2_+_33661392 0.495 NM_170672
RASGRP3
RAS guanyl releasing protein 3 (calcium and DAG-regulated)
chr5_+_159656436 0.491 NM_001445
FABP6
fatty acid binding protein 6, ileal
chr1_+_100111430 0.490 NM_017734
PALMD
palmdelphin
chr1_+_84609941 0.487 NM_182948
PRKACB
protein kinase, cAMP-dependent, catalytic, beta
chr13_-_45048436 0.473 NM_001243798
TSC22D1
TSC22 domain family, member 1
chr9_+_66553254 0.467 MGC21881
uncharacterized locus MGC21881
chr1_+_212475147 0.461 NM_001199756
PPP2R5A
protein phosphatase 2, regulatory subunit B', alpha
chr7_-_120498128 0.455 NM_012338
TSPAN12
tetraspanin 12
chr6_+_28249313 0.453 NM_001184743
NM_032507
PGBD1

piggyBac transposable element derived 1

chr12_-_71551564 0.443 TSPAN8
tetraspanin 8
chr1_-_21377452 0.439 EIF4G3
eukaryotic translation initiation factor 4 gamma, 3
chr13_-_48987017 0.433 LPAR6
lysophosphatidic acid receptor 6
chr10_-_116444374 0.425 NM_001003407
NM_001003408
ABLIM1

actin binding LIM protein 1

chr17_+_61086897 0.424 NM_025185
TANC2
tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2
chr1_-_21377387 0.422 EIF4G3
eukaryotic translation initiation factor 4 gamma, 3
chr4_+_114214102 0.411 ANK2
ankyrin 2, neuronal
chr5_-_160112266 0.408 ATP10B
ATPase, class V, type 10B
chr20_-_34117447 0.404 NM_001145350
C20orf173
chromosome 20 open reading frame 173
chr12_+_80603232 0.401 NM_173591
OTOGL
otogelin-like
chrX_+_105066531 0.398 NM_198465
NRK
Nik related kinase
chr17_-_3496122 0.397 NM_080706
TRPV1
transient receptor potential cation channel, subfamily V, member 1
chr4_+_134073180 0.394 PCDH10
protocadherin 10
chr6_+_143929316 0.394 NM_001100166
NM_014721
PHACTR2

phosphatase and actin regulator 2

chr8_+_76452202 0.394 NM_004133
HNF4G
hepatocyte nuclear factor 4, gamma
chr9_-_13250313 0.393 NM_003829
MPDZ
multiple PDZ domain protein
chr1_-_246670518 0.388 SMYD3
SET and MYND domain containing 3
chr3_-_112359277 0.387 CCDC80
coiled-coil domain containing 80
chrX_+_123095598 0.380 STAG2
stromal antigen 2
chr9_-_20622476 0.376 NM_004529
MLLT3
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3
chr1_-_67266930 0.367 NM_005478
INSL5
insulin-like 5
chr6_-_73935174 0.363 NM_001126063
KHDC1L
KH homology domain containing 1-like
chr14_-_23284565 0.363 SLC7A7
solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
chr4_-_88450243 0.358 SPARCL1
SPARC-like 1 (hevin)
chr9_-_125941304 0.353 STRBP
spermatid perinuclear RNA binding protein
chr17_-_72357957 0.349 NM_001080466
BTBD17
BTB (POZ) domain containing 17
chr7_+_16793320 0.349 NM_014399
TSPAN13
tetraspanin 13
chr2_-_192711651 0.346 SDPR
serum deprivation response
chr14_-_23284617 0.346 SLC7A7
solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
chr10_-_21786186 0.345 C10orf114
chromosome 10 open reading frame 114
chr5_+_68800003 0.345 NM_001205255
OCLN
occludin
chr4_-_186733372 0.340 NM_003603
NM_001145670
SORBS2

sorbin and SH3 domain containing 2

chr21_-_31864274 0.339 NM_181609
KRTAP19-3
keratin associated protein 19-3
chr7_-_92848837 0.334 NM_198151
HEPACAM2
HEPACAM family member 2
chr6_-_46922533 0.332 NM_015234
GPR116
G protein-coupled receptor 116
chr1_+_84764048 0.332 NM_001010971
SAMD13
sterile alpha motif domain containing 13
chrX_-_55057408 0.330 NM_000032
NM_001037967
NM_001037968
ALAS2


aminolevulinate, delta-, synthase 2


chr5_-_78281556 0.328 ARSB
arylsulfatase B
chr10_+_124670216 0.328 NM_001029888
FAM24A
family with sequence similarity 24, member A
chr16_+_55600583 0.327 NM_032330
CAPNS2
calpain, small subunit 2
chr6_+_35995583 0.324 MAPK14
mitogen-activated protein kinase 14
chr11_+_22689653 0.323 NM_177553
GAS2
growth arrest-specific 2
chr12_+_9142136 0.322 NM_005810
KLRG1
killer cell lectin-like receptor subfamily G, member 1
chr1_+_53480616 0.321 SCP2
sterol carrier protein 2
chr18_+_19353635 0.321 MIB1
mindbomb homolog 1 (Drosophila)
chr1_+_53480573 0.319 NM_001007099
NM_001007100
NM_001007250
SCP2


sterol carrier protein 2


chr7_-_92855780 0.317 NM_001039372
HEPACAM2
HEPACAM family member 2
chrX_-_100914816 0.314 NM_014782
NM_177949
ARMCX2

armadillo repeat containing, X-linked 2

chr12_-_50616425 0.312 NM_001113547
LIMA1
LIM domain and actin binding 1
chr13_-_20357043 0.311 PSPC1
paraspeckle component 1
chr19_-_2427530 0.308 TIMM13
translocase of inner mitochondrial membrane 13 homolog (yeast)
chr8_+_68864589 0.308 NM_024870
NM_025170
PREX2

phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2

chr2_-_220436267 0.308 NM_001173408
NM_001173431
NM_015311
OBSL1


obscurin-like 1


chr10_-_21786205 0.303 NM_001010911
C10orf114
chromosome 10 open reading frame 114
chr21_+_35190586 0.302 ITSN1
intersectin 1 (SH3 domain protein)
chr1_-_75199091 0.299 NM_001130042
NM_001130043
NM_001134759
NM_001889
CRYZ



crystallin, zeta (quinone reductase)



chr6_+_144612872 0.297 NM_007124
UTRN
utrophin
chrX_+_107683015 0.295 NM_000495
NM_033380
COL4A5

collagen, type IV, alpha 5

chr4_+_155484131 0.294 NM_001184741
NM_005141
FGB

fibrinogen beta chain

chr3_-_151058439 0.294 NM_176876
P2RY12
purinergic receptor P2Y, G-protein coupled, 12
chr7_-_108142934 0.290 PNPLA8
patatin-like phospholipase domain containing 8
chr3_+_152017193 0.289 NM_207293
NM_207294
NM_207295
NM_207296
NM_207297
MBNL1




muscleblind-like (Drosophila)




chr14_+_39649711 0.286 PNN
pinin, desmosome associated protein
chr13_-_99630243 0.284 NM_001130048
NM_001130050
DOCK9

dedicator of cytokinesis 9

chrX_-_19817854 0.282 SH3KBP1
SH3-domain kinase binding protein 1
chr22_-_24092951 0.281 NM_021916
ZNF70
zinc finger protein 70
chr3_-_71179736 0.277 FOXP1
forkhead box P1
chr14_-_100841793 0.274 WARS
tryptophanyl-tRNA synthetase
chr19_-_18433933 0.272 NM_001252129
NM_012321
LSM4

LSM4 homolog, U6 small nuclear RNA associated (S. cerevisiae)

chr3_-_149421059 0.269 NM_001168278
WWTR1
WW domain containing transcription regulator 1
chr9_+_12774988 0.265 NM_203403
C9orf150
chromosome 9 open reading frame 150
chr5_-_78281076 0.264 ARSB
arylsulfatase B
chr5_-_16742336 0.264 MYO10
myosin X
chr1_-_244006471 0.262 NM_005465
NM_181690
AKT3

v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma)

chr19_+_41430123 0.260 CYP2B7P1
cytochrome P450, family 2, subfamily B, polypeptide 7 pseudogene 1
chr10_-_116444112 0.259 ABLIM1
actin binding LIM protein 1
chr12_-_10978867 0.259 NM_023921
TAS2R10
taste receptor, type 2, member 10
chr14_+_63671101 0.258 NM_020663
RHOJ
ras homolog gene family, member J
chr3_-_112358510 0.257 CCDC80
coiled-coil domain containing 80
chr13_-_20357081 0.257 PSPC1
paraspeckle component 1
chr5_+_140602914 0.257 NM_018934
PCDHB14
protocadherin beta 14
chr4_-_170533536 0.252 NEK1
NIMA (never in mitosis gene a)-related kinase 1
chr15_+_80390757 0.251 NM_001242919
ZFAND6
zinc finger, AN1-type domain 6
chr14_-_95608054 0.249 NM_030621
DICER1
dicer 1, ribonuclease type III
chr13_-_61989654 0.249 NM_022843
PCDH20
protocadherin 20
chr5_+_140552201 0.247 NM_018940
PCDHB7
protocadherin beta 7
chrX_+_47092264 0.247 NM_004651
USP11
ubiquitin specific peptidase 11
chr4_-_70725792 0.245 NM_005420
SULT1E1
sulfotransferase family 1E, estrogen-preferring, member 1
chr18_+_6834431 0.244 NM_001010000
ARHGAP28
Rho GTPase activating protein 28
chr1_+_180601121 0.243 NM_001135669
NM_004736
XPR1

xenotropic and polytropic retrovirus receptor 1

chr10_-_65028825 0.243 NM_004241
JMJD1C
jumonji domain containing 1C
chr1_-_45253376 0.242 NM_153274
BEST4
bestrophin 4
chrX_+_14903412 0.242 NM_001177475
MOSPD2
motile sperm domain containing 2
chr5_+_108083522 0.240 NM_005246
FER
fer (fps/fes related) tyrosine kinase
chr3_-_112359547 0.239 CCDC80
coiled-coil domain containing 80
chr8_+_144451014 0.238 NM_052924
RHPN1
rhophilin, Rho GTPase binding protein 1
chr14_+_31494682 0.236 NM_001128126
NM_007077
AP4S1

adaptor-related protein complex 4, sigma 1 subunit

chr10_+_5488521 0.235 NM_005863
NET1
neuroepithelial cell transforming 1
chr17_+_20108298 0.231 SPECC1
sperm antigen with calponin homology and coiled-coil domains 1
chr5_-_88119604 0.231 NM_001193348
NM_001193349
MEF2C

myocyte enhancer factor 2C

chr13_-_41556360 0.230 NM_001145353
ELF1
E74-like factor 1 (ets domain transcription factor)
chrX_-_70473979 0.228 NM_201599
ZMYM3
zinc finger, MYM-type 3
chr13_+_58205788 0.228 NM_001040429
PCDH17
protocadherin 17
chr10_+_94594469 0.227 NM_001013848
EXOC6
exocyst complex component 6
chr12_-_58240493 0.225 CTDSP2
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 2
chr7_-_122342965 0.225 NM_198085
RNF148
ring finger protein 148
chrM_+_4465 0.223


chr5_+_76382458 0.223 LOC728723
uncharacterized LOC728723
chr3_+_148583042 0.223 NM_001870
CPA3
carboxypeptidase A3 (mast cell)
chr2_-_234474197 0.220 NM_018218
USP40
ubiquitin specific peptidase 40
chr6_-_75970566 0.220 TMEM30A
transmembrane protein 30A
chr3_-_114790221 0.220 NM_001164343
ZBTB20
zinc finger and BTB domain containing 20
chr10_+_101542460 0.219 NM_000392
ABCC2
ATP-binding cassette, sub-family C (CFTR/MRP), member 2
chr12_-_58240746 0.219 NM_005730
CTDSP2
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 2
chr8_-_66701175 0.216 NM_002603
PDE7A
phosphodiesterase 7A
chrX_-_71792897 0.216 NM_001166418
NM_001166419
NM_001166420
NM_001166422
NM_001166448
NM_018486
HDAC8





histone deacetylase 8





chr1_+_66458389 0.215 NM_001037340
PDE4B
phosphodiesterase 4B, cAMP-specific
chr12_-_71031174 0.214 NM_001109754
PTPRB
protein tyrosine phosphatase, receptor type, B
chr9_+_97521930 0.214 NM_001193329
C9orf3
chromosome 9 open reading frame 3
chr17_-_15523017 0.214 NM_006382
CDRT1
CMT1A duplicated region transcript 1
chr17_+_7743233 0.213 NM_001080424
KDM6B
lysine (K)-specific demethylase 6B
chr7_+_80267782 0.213 NM_000072
NM_001001548
CD36

CD36 molecule (thrombospondin receptor)

chr10_+_112344076 0.213 SMC3
structural maintenance of chromosomes 3
chr7_+_150065330 0.212 REPIN1
replication initiator 1
chr17_-_38721701 0.211 NM_001838
CCR7
chemokine (C-C motif) receptor 7
chr11_-_128894008 0.209 NM_014715
ARHGAP32
Rho GTPase activating protein 32
chr3_-_112359863 0.209 CCDC80
coiled-coil domain containing 80
chr9_-_15510209 0.209 NM_021144
PSIP1
PC4 and SFRS1 interacting protein 1
chr9_+_116263706 0.206 NM_130795
RGS3
regulator of G-protein signaling 3
chr12_-_10959578 0.206 NM_023918
TAS2R8
taste receptor, type 2, member 8

Gene Ontology Analysis

Nothing significant found in process category.

Nothing significant found in compartment category.

Gene overrepresentation in function category:

enrichment   p-value GO term description
9.51 4.53e-02 GO:0070064 proline-rich region binding