Motif ID: NKX6-1,2.p2

Z-value: 0.530


Transcription factors associated with NKX6-1,2.p2:

Gene SymbolEntrez IDGene Name
NKX6-1 4825 NK6 homeobox 1
NKX6-2 84504 NK6 homeobox 2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.p-valuePlot
NKX6-1chr4_-_854193860.135.4e-01Click!


Activity profile for motif NKX6-1,2.p2.

activity profile for motif NKX6-1,2.p2


Sorted Z-values histogram for motif NKX6-1,2.p2

Sorted Z-values for motif NKX6-1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NKX6-1,2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr4_-_186732047 0.828 NM_001145672
SORBS2
sorbin and SH3 domain containing 2
chr1_+_84647342 0.735 NM_001242862
PRKACB
protein kinase, cAMP-dependent, catalytic, beta
chr3_-_64211111 0.694 NM_198859
PRICKLE2
prickle homolog 2 (Drosophila)
chr1_+_61869699 0.651 NFIA
nuclear factor I/A
chr4_-_186733372 0.649 NM_003603
NM_001145670
SORBS2

sorbin and SH3 domain containing 2

chr4_-_16900028 0.642 LDB2
LIM domain binding 2
chr4_+_41700736 0.639 LIMCH1
LIM and calponin homology domains 1
chr4_-_16900256 0.619 LDB2
LIM domain binding 2
chr4_-_16900348 0.611 NM_001130834
NM_001290
LDB2

LIM domain binding 2

chr20_-_45927496 0.581 ZMYND8
zinc finger, MYND-type containing 8
chr5_-_88199868 0.481 NM_001131005
NM_001193347
MEF2C

myocyte enhancer factor 2C

chr12_+_32654976 0.479 NM_139241
FGD4
FYVE, RhoGEF and PH domain containing 4
chr21_-_31859666 0.468 NM_181608
KRTAP19-2
keratin associated protein 19-2
chr18_+_72922725 0.459 NM_005786
TSHZ1
teashirt zinc finger homeobox 1
chr6_+_136172802 0.451 NM_018945
PDE7B
phosphodiesterase 7B
chr1_+_210501595 0.450 NM_001122834
NM_001170564
HHAT

hedgehog acyltransferase

chr4_-_90759446 0.440 NM_001146055
SNCA
synuclein, alpha (non A4 component of amyloid precursor)
chr3_-_15839674 0.433 NM_001195098
ANKRD28
ankyrin repeat domain 28
chr3_-_168865521 0.404 NM_001164000
MECOM
MDS1 and EVI1 complex locus
chr13_+_103459495 0.374 NM_001204425
BIVM-ERCC5
BIVM
BIVM-ERCC5 readthrough
basic, immunoglobulin-like variable motif containing
chr12_+_27397077 0.369 NM_015000
STK38L
serine/threonine kinase 38 like
chr9_-_21385258 0.359 NM_000605
IFNA2
interferon, alpha 2
chr11_+_7618416 0.357 PPFIBP2
PTPRF interacting protein, binding protein 2 (liprin beta 2)
chr17_+_39382878 0.356 NM_031961
KRTAP9-2
keratin associated protein 9-2
chr16_+_25228282 0.355 NM_001169
AQP8
aquaporin 8
chr10_+_101542554 0.351 ABCC2
ATP-binding cassette, sub-family C (CFTR/MRP), member 2
chr10_+_101542460 0.339 NM_000392
ABCC2
ATP-binding cassette, sub-family C (CFTR/MRP), member 2
chr13_-_48987652 0.294 NM_001162498
LPAR6
lysophosphatidic acid receptor 6
chrX_+_36254050 0.293 NM_001098843
CXorf30
chromosome X open reading frame 30
chr12_-_52779362 0.286 NM_033045
KRT84
keratin 84
chrX_-_10535476 0.282 NM_001193278
NM_001193279
NM_001193280
NM_001193281
MID1



midline 1 (Opitz/BBB syndrome)



chr5_+_161275185 0.272 GABRA1
gamma-aminobutyric acid (GABA) A receptor, alpha 1
chr4_+_140587086 0.267 MGST2
microsomal glutathione S-transferase 2
chr19_-_10291056 0.262


chr5_+_161274939 0.259 NM_001127644
GABRA1
gamma-aminobutyric acid (GABA) A receptor, alpha 1
chr22_-_26961333 0.256 NM_001008566
TPST2
tyrosylprotein sulfotransferase 2
chr5_+_95066628 0.253 NM_014899
RHOBTB3
Rho-related BTB domain containing 3
chr17_-_67057046 0.251 NM_080283
ABCA9
ATP-binding cassette, sub-family A (ABC1), member 9
chr1_-_92351613 0.251 NM_001195683
NM_003243
TGFBR3

transforming growth factor, beta receptor III

chr12_+_111284763 0.247 NM_152591
CCDC63
coiled-coil domain containing 63
chr18_+_20735788 0.243 NM_138375
CABLES1
Cdk5 and Abl enzyme substrate 1
chr9_-_77643307 0.242 NM_152420
C9orf41
chromosome 9 open reading frame 41
chrX_-_33229428 0.237 NM_004006
DMD
dystrophin
chr15_+_36932805 0.236 NM_032499
C15orf41
chromosome 15 open reading frame 41
chr5_-_43040147 0.235 NM_001014279
C5orf39
chromosome 5 open reading frame 39
chr4_-_2230957 0.234 NM_181808
POLN
polymerase (DNA directed) nu
chr9_-_21202201 0.229 NM_021057
IFNA7
interferon, alpha 7
chr3_+_148583042 0.228 NM_001870
CPA3
carboxypeptidase A3 (mast cell)
chr19_-_48759141 0.227 NM_001184902
NM_001184904
CARD8

caspase recruitment domain family, member 8

chr13_-_48987247 0.225 LPAR6
lysophosphatidic acid receptor 6
chr17_-_39150384 0.224 NM_033185
KRTAP3-3
keratin associated protein 3-3
chr4_-_138453628 0.223 NM_019035
PCDH18
protocadherin 18
chr6_-_79675672 0.221 PHIP
pleckstrin homology domain interacting protein
chr3_+_16216155 0.221 NM_054110
GALNTL2
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase-like 2
chr1_-_197552304 0.220 DENND1B
DENN/MADD domain containing 1B
chrX_-_10544852 0.218 NM_001193277
MID1
midline 1 (Opitz/BBB syndrome)
chr5_-_111091947 0.214 NM_001142483
C5orf13
chromosome 5 open reading frame 13
chr4_-_186877869 0.213 NM_021069
SORBS2
sorbin and SH3 domain containing 2
chr1_+_100316530 0.211 NM_000646
AGL
amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase
chr2_-_73520448 0.211 NM_001965
EGR4
early growth response 4
chr20_+_16728997 0.209 NM_020157
OTOR
otoraplin
chr3_-_141747434 0.208 NM_001178141
NM_001178142
NM_006286
TFDP2


transcription factor Dp-2 (E2F dimerization partner 2)


chrX_+_66788682 0.204 NM_001011645
AR
androgen receptor
chr10_+_50887683 0.203 NM_001042427
NM_182554
C10orf53

chromosome 10 open reading frame 53

chr1_-_21377387 0.203 EIF4G3
eukaryotic translation initiation factor 4 gamma, 3
chr3_-_47957475 0.202


chr1_-_76397975 0.198 NM_080868
ASB17
ankyrin repeat and SOCS box containing 17
chr3_+_132036210 0.192 NM_001099
NM_001134194
ACPP

acid phosphatase, prostate

chr1_-_93342706 0.192 NM_001252271
FAM69A
family with sequence similarity 69, member A
chr15_-_65412175 0.191 PDCD7
programmed cell death 7
chr19_-_54876535 0.188 LAIR1
leukocyte-associated immunoglobulin-like receptor 1
chr19_-_46526555 0.187 NM_005091
PGLYRP1
peptidoglycan recognition protein 1
chr6_+_35226685 0.185 ZNF76
zinc finger protein 76
chr6_+_132859426 0.184 NM_175057
TAAR9
trace amine associated receptor 9 (gene/pseudogene)
chr8_-_28347733 0.181 NM_172366
FBXO16
ZNF395
F-box protein 16
zinc finger protein 395
chr2_-_238322840 0.180 NM_004369
NM_057164
NM_057165
NM_057166
NM_057167
COL6A3




collagen, type VI, alpha 3




chr2_-_238322815 0.180 COL6A3
collagen, type VI, alpha 3
chr1_+_84630575 0.178 NM_001242860
NM_001242861
PRKACB

protein kinase, cAMP-dependent, catalytic, beta

chr11_+_87032428 0.176 TMEM135
transmembrane protein 135
chr6_+_72922513 0.174 NM_001168407
NM_001168408
RIMS1

regulating synaptic membrane exocytosis 1

chr2_+_210444364 0.173 NM_002374
NM_031845
NM_031847
MAP2


microtubule-associated protein 2


chr22_-_29137776 0.172 NM_001005735
NM_007194
NM_145862
CHEK2


checkpoint kinase 2


chr2_+_109204904 0.169 NM_001193488
LIMS1
LIM and senescent cell antigen-like domains 1
chr7_+_94297448 0.168 PEG10
paternally expressed 10
chr18_-_3219986 0.166 NM_003803
NM_019856
MYOM1

myomesin 1, 185kDa

chr7_+_23286384 0.166 GPNMB
glycoprotein (transmembrane) nmb
chr1_+_244515936 0.164 NM_001012970
C1orf100
chromosome 1 open reading frame 100
chr1_+_15256295 0.164 NM_001018001
KAZN
kazrin, periplakin interacting protein
chrX_-_10851808 0.163 NM_033290
MID1
midline 1 (Opitz/BBB syndrome)
chr12_-_14849427 0.160 NM_004963
GUCY2C
guanylate cyclase 2C (heat stable enterotoxin receptor)
chr20_+_11898536 0.160 NM_014962
BTBD3
BTB (POZ) domain containing 3
chr7_+_77469446 0.159 NM_001127357
NM_001127359
NM_020432
PHTF2


putative homeodomain transcription factor 2


chr15_-_77154284 0.159 NM_001145923
SCAPER
S-phase cyclin A-associated protein in the ER
chr6_-_29323971 0.156 NM_030876
OR5V1
olfactory receptor, family 5, subfamily V, member 1
chr1_+_84630374 0.155 PRKACB
protein kinase, cAMP-dependent, catalytic, beta
chr12_+_25205488 0.154 LRMP
lymphoid-restricted membrane protein
chr10_+_35484054 0.152 NM_182717
NM_182718
NM_182719
NM_182720
CREM



cAMP responsive element modulator



chr1_+_145477018 0.151 NM_153713
LIX1L
Lix1 homolog (mouse)-like
chr8_+_79428335 0.151 NM_006823
NM_181839
PKIA

protein kinase (cAMP-dependent, catalytic) inhibitor alpha

chr1_+_104097321 0.150 NM_020978
AMY2B
amylase, alpha 2B (pancreatic)
chr13_-_45048436 0.150 NM_001243798
TSC22D1
TSC22 domain family, member 1
chr1_-_110155672 0.149 NM_005272
GNAT2
guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2
chr12_+_20963637 0.149 NM_019844
SLCO1B3
solute carrier organic anion transporter family, member 1B3
chr5_+_159614373 0.147 NM_001130958
FABP6
fatty acid binding protein 6, ileal
chr2_+_202047803 0.147 CASP10
caspase 10, apoptosis-related cysteine peptidase
chr9_-_75568232 0.146 NM_000689
ALDH1A1
aldehyde dehydrogenase 1 family, member A1
chr5_+_42565963 0.146 NM_001242460
NM_001242461
NM_001242462
GHR


growth hormone receptor


chr2_-_183387063 0.145 NM_005019
NM_001003683
PDE1A

phosphodiesterase 1A, calmodulin-dependent

chr14_-_78083109 0.145 NM_004863
SPTLC2
serine palmitoyltransferase, long chain base subunit 2
chr5_+_140613937 0.145 PCDHB18
protocadherin beta 18 pseudogene
chr12_+_107078476 0.144 NM_032491
RFX4
regulatory factor X, 4 (influences HLA class II expression)
chr7_+_23286386 0.143 GPNMB
glycoprotein (transmembrane) nmb
chr15_+_25281105 0.143 SNRPN
small nuclear ribonucleoprotein polypeptide N
chr17_+_74463629 0.142 NM_001088
AANAT
aralkylamine N-acetyltransferase
chr9_+_34652125 0.141 NM_001142784
IL11RA
interleukin 11 receptor, alpha
chr1_+_209878135 0.140 NM_005525
HSD11B1
hydroxysteroid (11-beta) dehydrogenase 1
chr1_+_114522029 0.139 NM_020190
OLFML3
olfactomedin-like 3
chr3_+_45927995 0.139 NM_006641
NM_031200
CCR9

chemokine (C-C motif) receptor 9

chr1_-_221915426 0.138 DUSP10
dual specificity phosphatase 10
chr14_-_75530716 0.137 NM_001107
NM_203488
ACYP1

acylphosphatase 1, erythrocyte (common) type

chr15_+_40643225 0.137 NM_001145643
PHGR1
proline/histidine/glycine-rich 1
chr4_-_140201339 0.137 NM_032623
C4orf49
chromosome 4 open reading frame 49
chr11_-_1629614 0.136 NM_001012708
KRTAP5-3
keratin associated protein 5-3
chr8_-_93111915 0.136 NM_001198628
RUNX1T1
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
chr6_+_147527102 0.136 STXBP5
syntaxin binding protein 5 (tomosyn)
chr3_-_126327397 0.136 NM_001039783
TXNRD3NB
thioredoxin reductase 3 neighbor
chr2_-_161056573 0.136 NM_000888
ITGB6
integrin, beta 6
chr1_-_21377452 0.135 EIF4G3
eukaryotic translation initiation factor 4 gamma, 3
chr1_+_20959946 0.135 NM_032409
PINK1
PTEN induced putative kinase 1
chr6_+_148663728 0.135 NM_015278
SASH1
SAM and SH3 domain containing 1
chr17_+_47866119 0.134 KAT7
K(lysine) acetyltransferase 7
chr19_-_49220213 0.132 NM_182574
MAMSTR
MEF2 activating motif and SAP domain containing transcriptional regulator
chr5_+_42565562 0.132 NM_001242406
GHR
growth hormone receptor
chr8_+_39771327 0.131 NM_002164
IDO1
indoleamine 2,3-dioxygenase 1
chr10_+_35426709 0.130 NM_183011
NM_183012
CREM

cAMP responsive element modulator

chr1_-_186417855 0.129 NM_022576
PDC
phosducin
chr7_-_14025826 0.128 NM_001163150
NM_001163151
NM_001163152
ETV1


ets variant 1


chr1_+_84609941 0.126 NM_182948
PRKACB
protein kinase, cAMP-dependent, catalytic, beta
chr5_-_179072004 0.125 NM_001142306
C5orf60
chromosome 5 open reading frame 60
chr7_-_92855780 0.125 NM_001039372
HEPACAM2
HEPACAM family member 2
chr1_+_196621007 0.124 NM_000186
NM_001014975
CFH

complement factor H

chr19_-_39368889 0.123 NM_001195833
NM_198445
RINL

Ras and Rab interactor-like

chr1_-_186430216 0.123 NM_002597
PDC
phosducin
chr17_+_68100994 0.123 NM_170742
KCNJ16
potassium inwardly-rectifying channel, subfamily J, member 16
chr19_+_2785464 0.123 NM_003249
THOP1
thimet oligopeptidase 1
chr1_+_182419255 0.123 NM_001137669
RGSL1
regulator of G-protein signaling like 1
chr6_+_96025343 0.123 NM_024641
MANEA
mannosidase, endo-alpha
chr17_-_57232524 0.122 SKA2
spindle and kinetochore associated complex subunit 2
chr1_+_12227050 0.122 NM_001066
TNFRSF1B
tumor necrosis factor receptor superfamily, member 1B
chr10_-_99052429 0.122 NM_001204300
NM_032900
ARHGAP19

Rho GTPase activating protein 19

chr21_-_31864274 0.121 NM_181609
KRTAP19-3
keratin associated protein 19-3
chr1_+_186798031 0.121 NM_024420
PLA2G4A
phospholipase A2, group IVA (cytosolic, calcium-dependent)
chr2_+_109204745 0.120 NM_004987
LIMS1
LIM and senescent cell antigen-like domains 1
chr1_+_15272414 0.120 NM_001017999
KAZN
kazrin, periplakin interacting protein
chr7_+_102553343 0.120 NM_001031692
NM_005824
LRRC17

leucine rich repeat containing 17

chr7_+_23286390 0.120 GPNMB
glycoprotein (transmembrane) nmb
chr19_+_15852200 0.119 NM_013938
OR10H3
olfactory receptor, family 10, subfamily H, member 3
chr16_+_31271277 0.119 NM_000632
NM_001145808
ITGAM

integrin, alpha M (complement component 3 receptor 3 subunit)

chr3_+_38347426 0.119 NM_004803
SLC22A14
solute carrier family 22, member 14
chr22_+_40573879 0.119 NM_001162501
NM_015088
TNRC6B

trinucleotide repeat containing 6B

chr2_-_165424993 0.117 GRB14
growth factor receptor-bound protein 14
chr14_+_60558628 0.117 NM_022495
C14orf135
chromosome 14 open reading frame 135
chr3_-_151102536 0.116 NM_022788
P2RY12
purinergic receptor P2Y, G-protein coupled, 12
chr20_-_25371435 0.116 NM_001042472
NM_015600
ABHD12

abhydrolase domain containing 12

chr5_-_88119604 0.116 NM_001193348
NM_001193349
MEF2C

myocyte enhancer factor 2C

chr4_-_70725792 0.114 NM_005420
SULT1E1
sulfotransferase family 1E, estrogen-preferring, member 1
chr16_+_31271311 0.114 ITGAM
integrin, alpha M (complement component 3 receptor 3 subunit)
chr2_-_192016293 0.113 NM_001243835
STAT4
signal transducer and activator of transcription 4
chr9_+_706744 0.113 NM_153186
KANK1
KN motif and ankyrin repeat domains 1
chr19_-_3029611 0.113 NM_001144762
TLE2
transducin-like enhancer of split 2 (E(sp1) homolog, Drosophila)
chr13_-_97646603 0.112 NM_080818
OXGR1
oxoglutarate (alpha-ketoglutarate) receptor 1
chr4_+_155484131 0.111 NM_001184741
NM_005141
FGB

fibrinogen beta chain

chr4_-_110723334 0.111 NM_000204
CFI
complement factor I
chr12_+_56324945 0.110 NM_001345
DGKA
diacylglycerol kinase, alpha 80kDa
chr14_+_101295409 0.109 MEG3
maternally expressed 3 (non-protein coding)
chr16_+_31271327 0.108 ITGAM
integrin, alpha M (complement component 3 receptor 3 subunit)
chr12_-_9913415 0.108 NM_001781
CD69
CD69 molecule
chr9_-_13250313 0.108 NM_003829
MPDZ
multiple PDZ domain protein
chr12_-_55378455 0.108 NM_001136030
KIAA0748
KIAA0748
chr2_+_234959345 0.107 NM_006944
SPP2
secreted phosphoprotein 2, 24kDa
chr5_+_42548144 0.106 NM_001242402
GHR
growth hormone receptor
chr16_-_3627353 0.105 NM_178844
NLRC3
NLR family, CARD domain containing 3
chr17_+_48821106 0.104 LUC7L3
LUC7-like 3 (S. cerevisiae)
chr4_+_83956238 0.104 NM_016129
COPS4
COP9 constitutive photomorphogenic homolog subunit 4 (Arabidopsis)
chr4_+_183245136 0.104 NM_001080477
ODZ3
odz, odd Oz/ten-m homolog 3 (Drosophila)
chr12_+_54393876 0.103 NM_006897
HOXC9
homeobox C9
chr14_-_60097531 0.103 NM_206852
RTN1
reticulon 1
chr3_-_105421044 0.103 CBLB
Cas-Br-M (murine) ecotropic retroviral transforming sequence b
chr5_+_166711842 0.103 NM_001122679
ODZ2
odz, odd Oz/ten-m homolog 2 (Drosophila)
chr14_-_60097314 0.103 RTN1
reticulon 1
chr1_+_53480616 0.102 SCP2
sterol carrier protein 2
chr10_+_74870209 0.102 NM_015901
NUDT13
nudix (nucleoside diphosphate linked moiety X)-type motif 13
chr7_+_23286277 0.102 NM_001005340
NM_002510
GPNMB

glycoprotein (transmembrane) nmb

chr9_-_21350885 0.102 NM_021002
IFNA6
interferon, alpha 6
chr1_-_221915393 0.101 DUSP10
dual specificity phosphatase 10
chr2_+_87755059 0.101 LINC00152
long intergenic non-protein coding RNA 152
chr12_+_28410132 0.101 NM_018318
CCDC91
coiled-coil domain containing 91
chr19_+_16059817 0.101 NM_001004465
OR10H4
olfactory receptor, family 10, subfamily H, member 4
chrX_+_80457302 0.100 NM_003022
SH3BGRL
SH3 domain binding glutamic acid-rich protein like
chr2_+_204801453 0.100 NM_012092
ICOS
inducible T-cell co-stimulator

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
2.98 4.12e-02 GO:0007156 homophilic cell adhesion

Nothing significant found in compartment category.

Nothing significant found in function category.