Motif ID: NR4A2.p2

Z-value: 0.731


Transcription factors associated with NR4A2.p2:

monomer

Gene SymbolEntrez IDGene Name
NR4A2 4929 nuclear receptor subfamily 4, group A, member 2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.p-valuePlot
NR4A2chr2_-_1571890400.029.3e-01Click!


Activity profile for motif NR4A2.p2.

activity profile for motif NR4A2.p2


Sorted Z-values histogram for motif NR4A2.p2

Sorted Z-values for motif NR4A2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NR4A2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr12_-_16759531 1.528 NM_018640
LMO3
LIM domain only 3 (rhombotin-like 2)
chr12_-_16759430 1.409 LMO3
LIM domain only 3 (rhombotin-like 2)
chr12_-_16759939 1.089 NM_001243613
LMO3
LIM domain only 3 (rhombotin-like 2)
chr3_-_123339178 0.944 MYLK
myosin light chain kinase
chr3_-_123339423 0.911 NM_053031
NM_053032
MYLK

myosin light chain kinase

chr12_-_16759733 0.818 NM_001243610
LMO3
LIM domain only 3 (rhombotin-like 2)
chr12_-_16758839 0.772 NM_001243612
LMO3
LIM domain only 3 (rhombotin-like 2)
chr12_+_78225068 0.764 NM_014903
NAV3
neuron navigator 3
chr12_-_16760935 0.736 NM_001001395
NM_001243609
LMO3

LIM domain only 3 (rhombotin-like 2)

chr4_+_81118639 0.721 NM_001099403
PRDM8
PR domain containing 8
chr12_+_56075329 0.709 NM_152637
METTL7B
methyltransferase like 7B
chr12_+_56075418 0.696 METTL7B
methyltransferase like 7B
chr20_+_44486219 0.643 NM_080752
ZSWIM3
zinc finger, SWIM-type containing 3
chr17_+_7533452 0.610 NM_001040
NM_001146279
NM_001146280
NM_001146281
SHBG



sex hormone-binding globulin



chr11_+_69455837 0.590 NM_053056
CCND1
cyclin D1
chr19_+_3880660 0.569 ATCAY
ataxia, cerebellar, Cayman type
chr19_+_3880617 0.533 NM_033064
ATCAY
ataxia, cerebellar, Cayman type
chr22_-_30960875 0.526 NM_004861
GAL3ST1
galactose-3-O-sulfotransferase 1
chr6_-_119470336 0.525 NM_001100411
FAM184A
family with sequence similarity 184, member A
chr2_+_219745243 0.511 NM_025216
WNT10A
wingless-type MMTV integration site family, member 10A
chr5_-_148034089 0.500 HTR4
5-hydroxytryptamine (serotonin) receptor 4
chr4_+_100495972 0.499 MTTP
microsomal triglyceride transfer protein
chr20_+_18794369 0.457 NM_178483
C20orf79
chromosome 20 open reading frame 79
chr22_+_31518923 0.450 NM_001002837
INPP5J
inositol polyphosphate-5-phosphatase J
chr8_+_145149985 0.450 CYC1
cytochrome c-1
chr16_+_31366519 0.443 ITGAX
integrin, alpha X (complement component 3 receptor 4 subunit)
chr1_-_116311330 0.431 CASQ2
calsequestrin 2 (cardiac muscle)
chr2_-_31637553 0.429 XDH
xanthine dehydrogenase
chr14_-_95942037 0.427 NM_152592
C14orf49
chromosome 14 open reading frame 49
chr19_+_15160194 0.426 NM_012114
CASP14
caspase 14, apoptosis-related cysteine peptidase
chr5_+_148731226 0.426 GRPEL2
GrpE-like 2, mitochondrial (E. coli)
chr6_+_34206567 0.424 NM_145905
HMGA1
high mobility group AT-hook 1
chr6_-_114384008 0.420 NM_153612
HS3ST5
heparan sulfate (glucosamine) 3-O-sulfotransferase 5
chr1_-_116311161 0.420 CASQ2
calsequestrin 2 (cardiac muscle)
chr17_-_32483550 0.419 NM_001094
ACCN1
amiloride-sensitive cation channel 1, neuronal
chr3_+_121774208 0.416 NM_001206924
NM_001206925
NM_175862
CD86


CD86 molecule


chr4_-_21699317 0.407 NM_001035003
KCNIP4
Kv channel interacting protein 4
chr19_-_51530781 0.404 NM_144947
KLK11
kallikrein-related peptidase 11
chr9_+_125132823 0.396 PTGS1
prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
chr20_-_62130390 0.390 NM_001958
EEF1A2
eukaryotic translation elongation factor 1 alpha 2
chr11_-_64528186 0.383 NM_001164716
NM_005609
PYGM

phosphorylase, glycogen, muscle

chr1_-_2564428 0.382 NM_033467
MMEL1
membrane metallo-endopeptidase-like 1
chr6_+_31554475 0.382 NM_205837
LST1
leukocyte specific transcript 1
chr9_-_117444368 0.376 NM_001199233
LOC100505478
uncharacterized LOC100505478
chr3_-_52188705 0.368 NM_001161580
NM_001161581
NM_015426
POC1A


POC1 centriolar protein homolog A (Chlamydomonas)


chr19_-_35719578 0.366 NM_152481
FAM187B
family with sequence similarity 187, member B
chr12_-_52779362 0.360 NM_033045
KRT84
keratin 84
chr17_+_32646058 0.358 NM_005623
CCL8
chemokine (C-C motif) ligand 8
chr2_+_228678556 0.357 NM_001130046
NM_004591
CCL20

chemokine (C-C motif) ligand 20

chr11_-_796175 0.354 NM_024698
SLC25A22
solute carrier family 25 (mitochondrial carrier: glutamate), member 22
chr6_+_31554975 0.348 NM_001166538
NM_007161
NM_205840
LST1


leukocyte specific transcript 1


chr19_+_45394642 0.347 TOMM40
translocase of outer mitochondrial membrane 40 homolog (yeast)
chr1_+_212738675 0.340 NM_001030287
ATF3
activating transcription factor 3
chr19_-_51568323 0.334 NM_015596
KLK13
kallikrein-related peptidase 13
chr15_+_78441737 0.333 IDH3A
isocitrate dehydrogenase 3 (NAD+) alpha
chr7_-_139763520 0.331 NM_022750
PARP12
poly (ADP-ribose) polymerase family, member 12
chr17_-_2614926 0.328 NM_015229
KIAA0664
KIAA0664
chr5_-_176981537 0.327 NM_001190946
FAM193B
family with sequence similarity 193, member B
chr5_+_161274196 0.322 NM_000806
GABRA1
gamma-aminobutyric acid (GABA) A receptor, alpha 1
chr13_-_33760215 0.318 NM_001243466
NM_178007
STARD13

StAR-related lipid transfer (START) domain containing 13

chr1_+_196857143 0.317 NM_001201550
NM_001201551
NM_006684
CFHR4


complement factor H-related 4


chr4_+_36283243 0.315 NM_001136536
DTHD1
death domain containing 1
chr19_-_51529869 0.313 NM_001136032
KLK11
kallikrein-related peptidase 11
chr1_+_27668462 0.312 NM_001193308
NM_032872
SYTL1

synaptotagmin-like 1

chr19_-_4535202 0.309 NM_001013706
PLIN5
perilipin 5
chr5_-_59783885 0.308 NM_001165899
PDE4D
phosphodiesterase 4D, cAMP-specific
chr9_+_17578952 0.307 NM_003026
SH3GL2
SH3-domain GRB2-like 2
chr1_+_205197031 0.307 NM_014858
TMCC2
transmembrane and coiled-coil domain family 2
chr19_-_48059112 0.301 NM_001101419
ZNF541
zinc finger protein 541
chr7_+_148287656 0.299 NM_145304
C7orf33
chromosome 7 open reading frame 33
chr6_-_32160289 0.297 GPSM3
G-protein signaling modulator 3
chr17_-_27948345 0.297 NM_032854
CORO6
coronin 6
chr10_-_101841593 0.295 NM_001308
CPN1
carboxypeptidase N, polypeptide 1
chr16_-_58328879 0.295 NM_001080492
PRSS54
protease, serine, 54
chr17_-_79623561 0.295 NM_002602
PDE6G
phosphodiesterase 6G, cGMP-specific, rod, gamma
chr22_+_39853534 0.295 MGAT3
mannosyl (beta-1,4-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase
chr17_-_40264687 0.293 NM_024119
DHX58
DEXH (Asp-Glu-X-His) box polypeptide 58
chr3_+_101546833 0.290 NM_001005474
NFKBIZ
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta
chr1_-_226128872 0.288 NM_001172425
NM_003240
LEFTY2

left-right determination factor 2

chr17_-_48474864 0.285 LRRC59
leucine rich repeat containing 59
chrX_-_151619669 0.285 NM_000808
GABRA3
gamma-aminobutyric acid (GABA) A receptor, alpha 3
chr16_+_57653649 0.285 GPR56
G protein-coupled receptor 56
chr17_-_56358118 0.284 MPO
myeloperoxidase
chr3_-_10332408 0.284 NM_001134941
NM_016362
GHRL

ghrelin/obestatin prepropeptide

chr2_+_75061234 0.282 HK2
hexokinase 2
chr19_+_45394459 0.281 NM_001128916
NM_001128917
NM_006114
TOMM40


translocase of outer mitochondrial membrane 40 homolog (yeast)


chr16_+_88519917 0.281 NM_153813
ZFPM1
zinc finger protein, multitype 1
chr7_+_86273219 0.280 NM_000840
GRM3
glutamate receptor, metabotropic 3
chr5_+_154092461 0.280 NM_015315
LARP1
La ribonucleoprotein domain family, member 1
chr1_+_113236679 0.280 MOV10
Mov10, Moloney leukemia virus 10, homolog (mouse)
chr1_+_119957553 0.272 NM_001166120
HSD3B2
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2
chr7_-_72936538 0.271 BAZ1B
bromodomain adjacent to zinc finger domain, 1B
chr11_-_84634219 0.269 DLG2
discs, large homolog 2 (Drosophila)
chr22_+_20909221 0.267 MED15
mediator complex subunit 15
chr16_+_57653909 0.267 NM_001145770
NM_005682
GPR56

G protein-coupled receptor 56

chr1_+_42619091 0.266 NM_007102
GUCA2B
guanylate cyclase activator 2B (uroguanylin)
chr3_-_46718898 0.265 NM_182775
ALS2CL
ALS2 C-terminal like
chr12_+_54891539 0.263 NCKAP1L
NCK-associated protein 1-like
chr19_-_11689765 0.262 NM_001111035
NM_001111036
ACP5

acid phosphatase 5, tartrate resistant

chr9_-_136344182 0.260 NM_001145099
NM_017585
SLC2A6

solute carrier family 2 (facilitated glucose transporter), member 6

chr7_+_128312345 0.260 NM_001012454
NM_001128926
FAM71F2

family with sequence similarity 71, member F2

chr3_+_10028579 0.259 LOC442075
uncharacterized LOC442075
chr8_+_67039130 0.259 NM_033058
NM_184085
NM_184086
NM_184087
TRIM55



tripartite motif containing 55



chr4_-_74864296 0.259 NM_002994
CXCL5
chemokine (C-X-C motif) ligand 5
chr3_-_78666943 0.258 ROBO1
roundabout, axon guidance receptor, homolog 1 (Drosophila)
chr9_-_85882093 0.257 NM_001244962
FRMD3
FERM domain containing 3
chr1_+_119957742 0.256 NM_000198
HSD3B2
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2
chr1_+_47603083 0.256 NM_001010969
CYP4A22
cytochrome P450, family 4, subfamily A, polypeptide 22
chr17_-_10276321 0.256 NM_003802
MYH13
myosin, heavy chain 13, skeletal muscle
chr1_+_159175048 0.256 NM_001122951
DARC
Duffy blood group, chemokine receptor
chr19_+_39899749 0.250


chr22_+_21128378 0.247 NM_000185
SERPIND1
serpin peptidase inhibitor, clade D (heparin cofactor), member 1
chr12_+_58013692 0.247 NM_133489
SLC26A10
solute carrier family 26, member 10
chr19_-_49401937 0.246 NM_003323
TULP2
tubby like protein 2
chr3_+_9745509 0.245 NM_153635
CPNE9
copine family member IX
chr15_-_43910959 0.245 NM_153700
STRC
stereocilin
chr12_-_53601051 0.244 ITGB7
integrin, beta 7
chr8_-_125740378 0.244 MTSS1
metastasis suppressor 1
chr19_+_45394522 0.243 TOMM40
translocase of outer mitochondrial membrane 40 homolog (yeast)
chr1_+_44412640 0.242 IPO13
importin 13
chr7_-_115670774 0.242 TFEC
transcription factor EC
chr15_+_66694216 0.241 MAP2K1
mitogen-activated protein kinase kinase 1
chr12_-_7281374 0.240 NM_031491
RBP5
retinol binding protein 5, cellular
chr19_-_49016418 0.239 NM_001080434
LMTK3
lemur tyrosine kinase 3
chr17_+_48610045 0.238 NM_017957
EPN3
epsin 3
chr4_-_76944585 0.238 NM_001565
CXCL10
chemokine (C-X-C motif) ligand 10
chr7_+_37960162 0.236 NM_001242946
NM_017549
EPDR1

ependymin related protein 1 (zebrafish)

chr1_+_27668499 0.235 SYTL1
synaptotagmin-like 1
chr11_+_1718424 0.235 NM_001012416
KRTAP5-6
keratin associated protein 5-6
chr13_-_46679143 0.235 NM_001872
NM_016413
CPB2

carboxypeptidase B2 (plasma)

chr8_-_30706532 0.234 NM_031271
TEX15
testis expressed 15
chr17_+_40439564 0.228 NM_003152
STAT5A
signal transducer and activator of transcription 5A
chr17_-_4167028 0.227 NM_016376
NM_020740
ANKFY1

ankyrin repeat and FYVE domain containing 1

chr17_-_8066254 0.226 NM_014232
VAMP2
vesicle-associated membrane protein 2 (synaptobrevin 2)
chr11_-_60719116 0.225 NM_016582
SLC15A3
solute carrier family 15, member 3
chr12_-_11244828 0.223 NM_176884
TAS2R43
TAS2R31
taste receptor, type 2, member 43
taste receptor, type 2, member 31
chr7_+_143079925 0.222 ZYX
zyxin
chr6_-_34101272 0.220 NM_000841
GRM4
glutamate receptor, metabotropic 4
chr20_-_1309809 0.220 NM_080489
SDCBP2
syndecan binding protein (syntenin) 2
chr11_-_123756339 0.220 NM_001013743
TMEM225
transmembrane protein 225
chr19_-_41388656 0.220 NM_000764
NM_030589
CYP2A7

cytochrome P450, family 2, subfamily A, polypeptide 7

chr5_-_59064437 0.220 NM_001197218
PDE4D
phosphodiesterase 4D, cAMP-specific
chr11_-_86666211 0.219 NM_012193
FZD4
frizzled family receptor 4
chr19_-_49496520 0.218 GYS1
glycogen synthase 1 (muscle)
chr22_-_36019363 0.218 NM_203377
MB
myoglobin
chr3_+_14716605 0.218 NM_001184957
NM_001184958
NM_032137
C3orf20


chromosome 3 open reading frame 20


chr3_-_45267068 0.217 TMEM158
transmembrane protein 158 (gene/pseudogene)
chr5_-_149792370 0.216 NM_001025158
NM_001025159
NM_004355
CD74


CD74 molecule, major histocompatibility complex, class II invariant chain


chr16_+_4674819 0.216 NM_001142289
NM_001142290
NM_001142291
NM_015246
MGRN1



mahogunin, ring finger 1



chr1_+_152881022 0.215 NM_005547
IVL
involucrin
chr6_+_160327972 0.214 NM_002377
MAS1
MAS1 oncogene
chr7_+_141478241 0.213 NM_016944
TAS2R4
taste receptor, type 2, member 4
chr16_-_48266181 0.210 NM_033151
ABCC11
ATP-binding cassette, sub-family C (CFTR/MRP), member 11
chr12_-_58135853 0.209 NM_014770
AGAP2
ArfGAP with GTPase domain, ankyrin repeat and PH domain 2
chr11_-_46408105 0.208 NM_000741
CHRM4
cholinergic receptor, muscarinic 4
chr19_+_33166312 0.208 NM_207391
RGS9BP
regulator of G protein signaling 9 binding protein
chrX_-_47489243 0.207 NM_001145252
CFP
complement factor properdin
chr20_-_48532036 0.205 SPATA2
spermatogenesis associated 2
chr5_+_145316120 0.205 NM_152550
SH3RF2
SH3 domain containing ring finger 2
chr8_+_145149978 0.204 CYC1
cytochrome c-1
chr12_+_12938540 0.202 NM_030817
APOLD1
apolipoprotein L domain containing 1
chr1_+_172389827 0.202 NM_139240
C1orf105
chromosome 1 open reading frame 105
chrX_+_13587693 0.202 NM_001167890
NM_015507
EGFL6

EGF-like-domain, multiple 6

chr16_+_4674829 0.201 MGRN1
mahogunin, ring finger 1
chr19_+_12949258 0.200 NM_014975
MAST1
microtubule associated serine/threonine kinase 1
chr7_+_149571029 0.199 ATP6V0E2
ATPase, H+ transporting V0 subunit e2
chr10_+_99185977 0.199 PGAM1
phosphoglycerate mutase 1 (brain)
chr6_-_33547833 0.197 BAK1
BCL2-antagonist/killer 1
chr18_-_46469118 0.197 NM_001190823
SMAD7
SMAD family member 7
chr5_+_133842276 0.197


chr13_-_43566301 0.197 NM_001002264
NM_033255
EPSTI1

epithelial stromal interaction 1 (breast)

chr19_-_49496566 0.196 NM_001161587
NM_002103
GYS1

glycogen synthase 1 (muscle)

chr2_+_210636700 0.196 NM_032504
NM_182587
UNC80

unc-80 homolog (C. elegans)

chr11_+_63993720 0.195 NM_001128612
NM_001128613
NM_032344
NUDT22


nudix (nucleoside diphosphate linked moiety X)-type motif 22


chr13_-_80912971 0.195 SPRY2
sprouty homolog 2 (Drosophila)
chr1_-_169599349 0.193 NM_003005
SELP
selectin P (granule membrane protein 140kDa, antigen CD62)
chr10_+_99186004 0.193 PGAM1
phosphoglycerate mutase 1 (brain)
chr22_-_38506532 0.193 BAIAP2L2
BAI1-associated protein 2-like 2
chr5_+_147691988 0.192 NM_032566
SPINK7
serine peptidase inhibitor, Kazal type 7 (putative)
chr17_+_36861857 0.191 NM_005937
MLLT6
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 6
chr17_+_79679399 0.191 SLC25A10
solute carrier family 25 (mitochondrial carrier; dicarboxylate transporter), member 10
chr8_+_145149936 0.190 NM_001916
CYC1
cytochrome c-1
chr10_-_14050453 0.189 FRMD4A
FERM domain containing 4A
chr2_-_25194484 0.188 DNAJC27
DnaJ (Hsp40) homolog, subfamily C, member 27
chr15_-_41120905 0.188 NM_001130143
NM_017726
PPP1R14D

protein phosphatase 1, regulatory (inhibitor) subunit 14D

chr5_-_131347518 0.188 NM_001205248
NM_001205251
NM_001205250
ACSL6


acyl-CoA synthetase long-chain family member 6


chr12_+_54891522 0.188 NCKAP1L
NCK-associated protein 1-like
chr16_-_68269948 0.188 NM_024939
ESRP2
epithelial splicing regulatory protein 2
chr10_+_99186012 0.188 PGAM1
phosphoglycerate mutase 1 (brain)
chr5_-_134914968 0.188 NM_004887
CXCL14
chemokine (C-X-C motif) ligand 14
chr11_-_34379526 0.187 NM_145804
ABTB2
ankyrin repeat and BTB (POZ) domain containing 2
chr1_-_152552962 0.187 NM_032563
LCE3D
late cornified envelope 3D
chr9_-_117150217 0.186 AKNA
AT-hook transcription factor
chr5_+_132209354 0.186 NM_052971
LEAP2
liver expressed antimicrobial peptide 2
chr19_+_11976843 0.184 NM_152262
ZNF439
zinc finger protein 439
chr14_-_61191027 0.184 SIX4
SIX homeobox 4
chr1_+_236849753 0.184 NM_001103
ACTN2
actinin, alpha 2
chr3_-_124653571 0.184 NM_033049
MUC13
mucin 13, cell surface associated
chr8_-_125740650 0.183 NM_014751
MTSS1
metastasis suppressor 1
chr7_+_45614179 0.183 ADCY1
adenylate cyclase 1 (brain)

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.24 1.37e-06 GO:0023052 signaling
1.47 3.36e-05 GO:0007154 cell communication
1.08 4.97e-05 GO:0009987 cellular process
1.23 6.26e-05 GO:0007165 signal transduction
1.12 9.09e-05 GO:0065007 biological regulation
1.51 3.90e-04 GO:0007267 cell-cell signaling
1.12 6.13e-04 GO:0050789 regulation of biological process
1.20 8.07e-04 GO:0051179 localization
1.18 1.17e-03 GO:0051716 cellular response to stimulus
1.44 1.35e-03 GO:0006811 ion transport
1.22 1.66e-03 GO:0006810 transport
1.22 2.40e-03 GO:0051234 establishment of localization
1.25 6.72e-03 GO:0065008 regulation of biological quality
1.28 7.15e-03 GO:0007166 cell surface receptor linked signaling pathway
1.14 8.08e-03 GO:0032501 multicellular organismal process
1.11 1.18e-02 GO:0050794 regulation of cellular process
1.41 1.53e-02 GO:0044093 positive regulation of molecular function
1.17 1.86e-02 GO:0032502 developmental process
1.21 2.67e-02 GO:0048518 positive regulation of biological process
1.36 3.22e-02 GO:0009605 response to external stimulus
1.24 3.79e-02 GO:0030154 cell differentiation
1.55 4.26e-02 GO:0046903 secretion

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.24 1.16e-03 GO:0044459 plasma membrane part
1.39 4.16e-03 GO:0005626 insoluble fraction
1.33 4.71e-03 GO:0000267 cell fraction
1.77 1.32e-02 GO:0030141 stored secretory granule
1.37 1.35e-02 GO:0005624 membrane fraction

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.13 1.74e-05 GO:0005515 protein binding
1.48 2.18e-04 GO:0015075 ion transmembrane transporter activity
1.40 7.60e-04 GO:0022857 transmembrane transporter activity
2.08 9.86e-04 GO:0008509 anion transmembrane transporter activity
1.41 1.15e-03 GO:0022891 substrate-specific transmembrane transporter activity
1.37 1.69e-03 GO:0022892 substrate-specific transporter activity
1.06 1.06e-02 GO:0005488 binding
1.29 3.93e-02 GO:0005215 transporter activity
1.37 4.37e-02 GO:0019899 enzyme binding