Motif ID: PAX2.p2

Z-value: 1.772


Transcription factors associated with PAX2.p2:

Gene SymbolEntrez IDGene Name
PAX2 5076 paired box 2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.p-valuePlot
PAX2chr10_+_1025053370.545.7e-03Click!


Activity profile for motif PAX2.p2.

activity profile for motif PAX2.p2


Sorted Z-values histogram for motif PAX2.p2

Sorted Z-values for motif PAX2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of PAX2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr2_-_136875629 4.410 NM_003467
CXCR4
chemokine (C-X-C motif) receptor 4
chr13_+_48877950 3.962 RB1
retinoblastoma 1
chr1_+_77747602 3.430 NM_174858
AK5
adenylate kinase 5
chr11_-_119252267 3.331 USP2
ubiquitin specific peptidase 2
chr17_+_47866061 3.265 KAT7
K(lysine) acetyltransferase 7
chr17_+_47865980 3.171 NM_001199155
NM_001199156
NM_001199157
NM_001199158
NM_007067
KAT7




K(lysine) acetyltransferase 7




chr8_-_9009050 3.095 NM_001201329
PPP1R3B
protein phosphatase 1, regulatory subunit 3B
chr11_-_116968986 3.088 NM_025164
SIK3
SIK family kinase 3
chr13_+_48877886 3.013 RB1
retinoblastoma 1
chr3_-_122512526 2.954 NM_024610
HSPBAP1
HSPB (heat shock 27kDa) associated protein 1
chr15_-_70994608 2.930 NM_001008224
UACA
uveal autoantigen with coiled-coil domains and ankyrin repeats
chr4_+_41614725 2.921 LIMCH1
LIM and calponin homology domains 1
chr17_-_46688279 2.905 HOXB7
homeobox B7
chr17_+_47866119 2.786 KAT7
K(lysine) acetyltransferase 7
chr12_-_9102193 2.776 M6PR
mannose-6-phosphate receptor (cation dependent)
chr13_+_48878025 2.763 RB1
retinoblastoma 1
chr18_+_77155943 2.745 NFATC1
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
chr6_-_144329342 2.704 NM_001080952
NM_001080953
NM_001080954
NM_001080956
NM_002656
NM_006718
PLAGL1





HYMAI
pleiomorphic adenoma gene-like 1





hydatidiform mole associated and imprinted (non-protein coding)
chr17_-_46688362 2.695 NM_004502
HOXB7
homeobox B7
chr4_+_41540320 2.667 LIMCH1
LIM and calponin homology domains 1
chr4_+_41614933 2.658 LIMCH1
LIM and calponin homology domains 1
chr18_+_77160243 2.646 NM_172387
NM_172389
NFATC1

nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1

chr8_+_120220554 2.645 NM_052886
MAL2
mal, T-cell differentiation protein 2 (gene/pseudogene)
chr13_-_110438896 2.601 NM_003749
IRS2
insulin receptor substrate 2
chr18_+_77155966 2.564 NFATC1
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
chr10_+_82173574 2.551 NM_001243778
NM_001243782
C10orf58

chromosome 10 open reading frame 58

chr2_-_136873740 2.513 NM_001008540
CXCR4
chemokine (C-X-C motif) receptor 4
chr1_-_11866079 2.471 NM_005957
MTHFR
methylenetetrahydrofolate reductase (NAD(P)H)
chr16_-_4588738 2.435 NM_001199055
NM_001199056
NM_013399
C16orf5


chromosome 16 open reading frame 5


chr12_+_105501556 2.392


chr7_+_30960914 2.309 NM_001185060
NM_001185061
NM_001185062
AQP1


aquaporin 1 (Colton blood group)


chr5_-_132299248 2.309 AFF4
AF4/FMR2 family, member 4
chr9_-_107690526 2.293 NM_005502
ABCA1
ATP-binding cassette, sub-family A (ABC1), member 1
chr18_+_77155927 2.266 NFATC1
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
chr17_+_39382878 2.264 NM_031961
KRTAP9-2
keratin associated protein 9-2
chr8_-_95274540 2.189 NM_005261
NM_181702
GEM

GTP binding protein overexpressed in skeletal muscle

chr18_+_77155714 2.167 NM_006162
NM_172388
NM_172390
NFATC1


nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1


chr6_+_34857021 2.130 NM_015245
ANKS1A
ankyrin repeat and sterile alpha motif domain containing 1A
chr17_-_46687925 2.111 HOXB7
homeobox B7
chr12_-_65153182 2.104 GNS
glucosamine (N-acetyl)-6-sulfatase
chr3_+_113465901 2.082 ATP6V1A
ATPase, H+ transporting, lysosomal 70kDa, V1 subunit A
chr2_-_160654668 2.056 CD302
CD302 molecule
chr1_+_100111430 2.052 NM_017734
PALMD
palmdelphin
chr4_-_186697065 2.041 NM_001145673
SORBS2
sorbin and SH3 domain containing 2
chr13_+_48877775 2.036 NM_000321
RB1
retinoblastoma 1
chr2_-_28113954 2.036 LOC100302650
uncharacterized LOC100302650
chr10_+_102107256 2.034


chr18_+_20513277 2.019 NM_002894
RBBP8
retinoblastoma binding protein 8
chr12_+_100661158 1.998 SCYL2
SCY1-like 2 (S. cerevisiae)
chrX_+_101975641 1.967 NM_001142524
NM_001142525
NM_001142526
NM_001142527
NM_001142528
NM_030639
BHLHB9





basic helix-loop-helix domain containing, class B, 9





chr6_+_116832807 1.958 NM_153711
FAM26E
family with sequence similarity 26, member E
chr8_-_22550708 1.936 NM_004430
EGR3
early growth response 3
chr12_+_105501537 1.934 KIAA1033
KIAA1033
chr13_+_48877900 1.931 RB1
retinoblastoma 1
chr8_-_95274520 1.925 GEM
GTP binding protein overexpressed in skeletal muscle
chr10_-_46090191 1.913 NM_001002265
NM_145021
MARCH8

membrane-associated ring finger (C3HC4) 8

chr4_+_100871625 1.887 LOC256880
uncharacterized LOC256880
chr17_-_67138013 1.883 NM_080284
ABCA6
ATP-binding cassette, sub-family A (ABC1), member 6
chr19_+_11200124 1.880 LDLR
low density lipoprotein receptor
chr4_+_78079302 1.872 CCNG2
cyclin G2
chr14_-_54955664 1.864 GMFB
glia maturation factor, beta
chr20_+_42544781 1.848 NM_001098796
NM_032883
TOX2

TOX high mobility group box family member 2

chr12_-_9102262 1.837 NM_001207024
NM_002355
M6PR

mannose-6-phosphate receptor (cation dependent)

chr12_+_52445185 1.828 NM_002135
NM_173157
NR4A1

nuclear receptor subfamily 4, group A, member 1

chr17_-_76124767 1.815 TMC6
transmembrane channel-like 6
chr14_-_54955714 1.815 NM_004124
GMFB
glia maturation factor, beta
chr4_+_41614911 1.805 NM_001112719
NM_001112720
LIMCH1

LIM and calponin homology domains 1

chr7_-_86688944 1.780 NM_001142749
KIAA1324L
KIAA1324-like
chr11_+_108093558 1.774 NM_000051
ATM
ataxia telangiectasia mutated
chr5_+_172483285 1.765 NM_001168393
NM_001168394
NM_153607
C5orf41


chromosome 5 open reading frame 41


chr11_+_125034604 1.761 PKNOX2
PBX/knotted 1 homeobox 2
chr17_+_25621105 1.744 NM_015626
NM_134265
WSB1

WD repeat and SOCS box containing 1

chr12_+_105501545 1.741 KIAA1033
KIAA1033
chr3_+_158519888 1.734 MFSD1
major facilitator superfamily domain containing 1
chr2_-_197036301 1.731 NM_004226
STK17B
serine/threonine kinase 17b
chr3_+_112280871 1.700 NM_017945
SLC35A5
solute carrier family 35, member A5
chr12_+_100660846 1.685 SCYL2
SCY1-like 2 (S. cerevisiae)
chr5_-_132298973 1.674 AFF4
AF4/FMR2 family, member 4
chr5_-_100238870 1.672 NM_175052
NM_005668
ST8SIA4

ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4

chr21_+_18885296 1.670 CXADR
coxsackie virus and adenovirus receptor
chr10_+_35416089 1.664 CREM
cAMP responsive element modulator
chr13_+_48877887 1.662 RB1
retinoblastoma 1
chr10_+_69644341 1.661 NM_012238
SIRT1
sirtuin 1
chr9_+_82187469 1.644 TLE4
transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)
chr10_-_125853102 1.641 CHST15
carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15
chr14_+_68086633 1.639 ARG2
arginase, type II
chr10_-_64576074 1.636 EGR2
early growth response 2
chr6_+_143999058 1.627 NM_001100164
NM_001100165
PHACTR2

phosphatase and actin regulator 2

chr10_-_64576123 1.626 NM_000399
NM_001136177
NM_001136179
EGR2


early growth response 2


chr8_+_97506478 1.616 SDC2
syndecan 2
chr2_-_160654736 1.615 NM_001198763
NM_001198764
NM_014880
CD302


CD302 molecule


chr17_-_57184116 1.608 TRIM37
tripartite motif containing 37
chr3_-_98241357 1.598 CLDND1
claudin domain containing 1
chr2_-_225266710 1.597 NM_001122779
NM_024785
FAM124B

family with sequence similarity 124B

chr16_-_23521794 1.592 GGA2
golgi-associated, gamma adaptin ear containing, ARF binding protein 2
chr7_-_129592711 1.584 NM_001202498
UBE2H
ubiquitin-conjugating enzyme E2H
chr19_-_45681454 1.572 NM_024108
TRAPPC6A
trafficking protein particle complex 6A
chr1_+_78470593 1.559 NM_007034
DNAJB4
DnaJ (Hsp40) homolog, subfamily B, member 4
chr18_+_77253324 1.549 NFATC1
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
chr16_-_23521719 1.533 GGA2
golgi-associated, gamma adaptin ear containing, ARF binding protein 2
chr7_+_116312412 1.532 NM_000245
NM_001127500
MET

met proto-oncogene (hepatocyte growth factor receptor)

chr8_-_80993009 1.531 NM_001025252
TPD52
tumor protein D52
chr6_-_30712294 1.530 NM_003897
IER3
immediate early response 3
chr17_-_8424217 1.525 MYH10
myosin, heavy chain 10, non-muscle
chr17_+_56769953 1.523 NM_002876
NM_058216
RAD51C

RAD51 homolog C (S. cerevisiae)

chr3_+_158519877 1.511 MFSD1
major facilitator superfamily domain containing 1
chr19_-_19051112 1.510 NM_001145722
NM_001145721
HOMER3

homer homolog 3 (Drosophila)

chr1_+_84630014 1.485 NM_001242857
NM_001242858
NM_001242859
PRKACB


protein kinase, cAMP-dependent, catalytic, beta


chr18_+_77659446 1.478


chr12_-_65153148 1.466 GNS
glucosamine (N-acetyl)-6-sulfatase
chr17_+_56769929 1.466 RAD51C
RAD51 homolog C (S. cerevisiae)
chr3_+_158519911 1.465 MFSD1
major facilitator superfamily domain containing 1
chr9_+_120466625 1.462 TLR4
toll-like receptor 4
chr14_-_88459459 1.459 GALC
galactosylceramidase
chr15_-_66084544 1.455 NM_001144823
NM_005848
DENND4A

DENN/MADD domain containing 4A

chr9_-_140196702 1.453 NM_001004354
NRARP
NOTCH-regulated ankyrin repeat protein
chr14_-_74551159 1.452 NM_005589
ALDH6A1
aldehyde dehydrogenase 6 family, member A1
chr7_-_129592794 1.419 NM_003344
NM_182697
UBE2H

ubiquitin-conjugating enzyme E2H

chr6_+_15246299 1.417 NM_004973
JARID2
jumonji, AT rich interactive domain 2
chr13_-_72440143 1.415 DACH1
dachshund homolog 1 (Drosophila)
chr6_-_84937313 1.405 NM_014895
KIAA1009
KIAA1009
chr14_+_64682671 1.399 NM_182910
SYNE2
spectrin repeat containing, nuclear envelope 2
chr9_+_82187599 1.397 TLE4
transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)
chr17_-_47841517 1.394 NM_030802
FAM117A
family with sequence similarity 117, member A
chr7_+_102553343 1.394 NM_001031692
NM_005824
LRRC17

leucine rich repeat containing 17

chr12_-_65153055 1.394 GNS
glucosamine (N-acetyl)-6-sulfatase
chr1_+_212458867 1.391 NM_006243
PPP2R5A
protein phosphatase 2, regulatory subunit B', alpha
chr9_-_13279562 1.383 MPDZ
multiple PDZ domain protein
chr19_+_11200146 1.374 LDLR
low density lipoprotein receptor
chr14_+_53019865 1.373 NM_001099652
GPR137C
G protein-coupled receptor 137C
chr1_-_155939051 1.362 ARHGEF2
Rho/Rac guanine nucleotide exchange factor (GEF) 2
chr2_+_109204777 1.347 LIMS1
LIM and senescent cell antigen-like domains 1
chrX_+_102883647 1.344 NM_001006640
TCEAL1
transcription elongation factor A (SII)-like 1
chr1_-_211752052 1.340 NM_021194
SLC30A1
solute carrier family 30 (zinc transporter), member 1
chrX_+_102883891 1.337 NM_001006639
NM_004780
TCEAL1

transcription elongation factor A (SII)-like 1

chr10_-_3827205 1.334 KLF6
Kruppel-like factor 6
chr10_-_93392857 1.332 NM_005398
PPP1R3C
protein phosphatase 1, regulatory subunit 3C
chr11_-_18343670 1.330 NM_007216
NM_181507
NM_181508
HPS5


Hermansky-Pudlak syndrome 5


chr17_+_4402128 1.328 NM_001124758
SPNS2
spinster homolog 2 (Drosophila)
chr11_-_119252364 1.324 NM_001243759
NM_004205
USP2

ubiquitin specific peptidase 2

chr16_-_23521803 1.324 NM_015044
GGA2
golgi-associated, gamma adaptin ear containing, ARF binding protein 2
chr1_+_84630374 1.315 PRKACB
protein kinase, cAMP-dependent, catalytic, beta
chr2_-_165477818 1.309 GRB14
growth factor receptor-bound protein 14
chr10_-_93392744 1.306 PPP1R3C
protein phosphatase 1, regulatory subunit 3C
chr5_-_81046858 1.303 SSBP2
single-stranded DNA binding protein 2
chrX_+_10124984 1.297 NM_001830
CLCN4
chloride channel 4
chr3_-_18480203 1.295 NM_001131010
SATB1
SATB homeobox 1
chr17_+_25621141 1.293 WSB1
WD repeat and SOCS box containing 1
chr14_+_24583979 1.280 NM_025230
DCAF11
DDB1 and CUL4 associated factor 11
chr7_-_121784236 1.279 NM_005763
AASS
aminoadipate-semialdehyde synthase
chr10_+_35416384 1.277 NM_181571
NM_183060
CREM

cAMP responsive element modulator

chr14_+_96505566 1.277 NM_001252507
C14orf132
chromosome 14 open reading frame 132
chr10_+_102123420 1.271


chr1_+_77747727 1.264 AK5
adenylate kinase 5
chr5_+_137801166 1.263 EGR1
early growth response 1
chr17_-_35656691 1.260 NM_198837
NM_198838
ACACA

acetyl-CoA carboxylase alpha

chr17_-_49337370 1.258 NM_017643
MBTD1
mbt domain containing 1
chr1_+_11866240 1.258 CLCN6
chloride channel 6
chr14_+_24584009 1.257 DCAF11
DDB1 and CUL4 associated factor 11
chr14_+_24583905 1.251 NM_001163484
DCAF11
DDB1 and CUL4 associated factor 11
chr2_+_33172368 1.249 NM_206943
LTBP1
latent transforming growth factor beta binding protein 1
chr12_-_42877413 1.249 NM_001144881
PRICKLE1
prickle homolog 1 (Drosophila)
chr4_+_42399855 1.247 NM_001080505
SHISA3
shisa homolog 3 (Xenopus laevis)
chr10_+_76586299 1.246 NM_012330
KAT6B
K(lysine) acetyltransferase 6B
chr2_-_111230651 1.245 NM_001205288
NM_033514
LIMS3-LOC440895
LIMS3L
LIMS3
LIMS3-LOC440895 readthrough
LIM and senescent cell antigen-like domains 3-like
LIM and senescent cell antigen-like domains 3
chrX_+_118108575 1.240 LONRF3
LON peptidase N-terminal domain and ring finger 3
chr12_+_53442732 1.236 NM_015319
TENC1
tensin like C1 domain containing phosphatase (tensin 2)
chr5_+_137801178 1.235 NM_001964
EGR1
early growth response 1
chr8_+_42128821 1.232 IKBKB
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
chr12_+_79257772 1.231 NM_001135805
SYT1
synaptotagmin I
chrX_+_107069459 1.227 MID2
midline 2
chr17_+_4046941 1.224 CYB5D2
cytochrome b5 domain containing 2
chr12_+_82752275 1.222 NM_032230
C12orf26
chromosome 12 open reading frame 26
chrX_+_102631408 1.215 NGFRAP1
nerve growth factor receptor (TNFRSF16) associated protein 1
chr14_+_24584467 1.214 NM_181357
DCAF11
DDB1 and CUL4 associated factor 11
chr2_-_216300444 1.214 FN1
fibronectin 1
chr2_+_87755059 1.213 LINC00152
long intergenic non-protein coding RNA 152
chr6_+_15245702 1.208 JARID2
jumonji, AT rich interactive domain 2
chr9_-_97356007 1.206 NM_003837
FBP2
fructose-1,6-bisphosphatase 2
chr10_-_97321094 1.205 NM_015385
NM_024991
SORBS1

sorbin and SH3 domain containing 1

chr16_-_88772732 1.205 NM_001171815
RNF166
ring finger protein 166
chr16_-_23521755 1.203 GGA2
golgi-associated, gamma adaptin ear containing, ARF binding protein 2
chr6_+_17393610 1.198 NM_006366
CAP2
CAP, adenylate cyclase-associated protein, 2 (yeast)
chr3_+_112280911 1.194 SLC35A5
solute carrier family 35, member A5
chr6_+_127587984 1.183 RNF146
ring finger protein 146
chr11_-_82782883 1.174 NM_014488
RAB30
RAB30, member RAS oncogene family
chr12_-_56727720 1.173 NM_001166279
NM_014871
PAN2

PAN2 poly(A) specific ribonuclease subunit homolog (S. cerevisiae)

chr1_-_113498615 1.172 NM_001166496
SLC16A1
solute carrier family 16, member 1 (monocarboxylic acid transporter 1)
chr5_-_39424930 1.164 DAB2
disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)
chr11_+_58390145 1.162 NM_000614
CNTF
ciliary neurotrophic factor
chrX_+_118108595 1.160 NM_001031855
NM_024778
LONRF3

LON peptidase N-terminal domain and ring finger 3

chr16_-_2097818 1.152 NM_002528
NTHL1
nth endonuclease III-like 1 (E. coli)
chr7_+_1097140 1.148 NM_138445
GPR146
G protein-coupled receptor 146
chr16_-_30107492 1.147 NM_031477
NM_001145524
YPEL3

yippee-like 3 (Drosophila)

chr14_-_88459469 1.146 NM_000153
NM_001201401
GALC

galactosylceramidase

chr14_-_64970319 1.145 NM_006977
ZBTB25
zinc finger and BTB domain containing 25
chr6_-_80656870 1.140 NM_022726
ELOVL4
ELOVL fatty acid elongase 4
chr1_+_32757702 1.139 HDAC1
histone deacetylase 1
chr11_+_7618416 1.139 PPFIBP2
PTPRF interacting protein, binding protein 2 (liprin beta 2)
chr15_-_66084438 1.137 DENND4A
DENN/MADD domain containing 4A

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.09 2.64e-06 GO:0009987 cellular process
1.15 6.64e-05 GO:0044237 cellular metabolic process
1.26 2.63e-04 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.23 3.46e-04 GO:0006807 nitrogen compound metabolic process
1.13 4.83e-04 GO:0008152 metabolic process
1.22 1.04e-03 GO:0034641 cellular nitrogen compound metabolic process
1.13 5.53e-03 GO:0044238 primary metabolic process
1.26 7.34e-03 GO:0090304 nucleic acid metabolic process
1.17 8.69e-03 GO:0051716 cellular response to stimulus
1.15 1.25e-02 GO:0043170 macromolecule metabolic process
1.16 1.31e-02 GO:0044260 cellular macromolecule metabolic process

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.11 4.23e-12 GO:0005622 intracellular
1.11 6.83e-12 GO:0044424 intracellular part
1.14 1.14e-08 GO:0005737 cytoplasm
1.13 1.48e-07 GO:0043231 intracellular membrane-bounded organelle
1.12 1.57e-07 GO:0043227 membrane-bounded organelle
1.11 1.99e-07 GO:0043229 intracellular organelle
1.11 3.68e-07 GO:0043226 organelle
1.17 1.17e-06 GO:0044444 cytoplasmic part
1.81 6.52e-05 GO:0005773 vacuole
1.83 3.69e-04 GO:0000323 lytic vacuole
1.83 3.69e-04 GO:0005764 lysosome
1.98 4.34e-03 GO:0044437 vacuolar part
1.97 7.60e-03 GO:0005774 vacuolar membrane
1.12 9.54e-03 GO:0005634 nucleus
1.12 1.08e-02 GO:0044422 organelle part
1.03 1.12e-02 GO:0005623 cell
1.03 1.45e-02 GO:0044464 cell part
1.52 1.58e-02 GO:0005768 endosome
2.06 2.05e-02 GO:0005765 lysosomal membrane
1.12 2.67e-02 GO:0044446 intracellular organelle part

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.19 3.40e-12 GO:0005515 protein binding
1.08 8.09e-07 GO:0005488 binding