Motif ID: PBX1.p2

Z-value: 0.784


Transcription factors associated with PBX1.p2:

Gene SymbolEntrez IDGene Name
PBX1 5087 pre-B-cell leukemia homeobox 1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.p-valuePlot
PBX1chr1_+_1645285860.864.9e-08Click!


Activity profile for motif PBX1.p2.

activity profile for motif PBX1.p2


Sorted Z-values histogram for motif PBX1.p2

Sorted Z-values for motif PBX1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of PBX1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr12_+_79258588 3.276 SYT1
synaptotagmin I
chr3_+_193853937 3.243 HES1
hairy and enhancer of split 1, (Drosophila)
chr2_+_12856813 3.160 NM_021643
TRIB2
tribbles homolog 2 (Drosophila)
chr3_+_193853930 2.924 NM_005524
HES1
hairy and enhancer of split 1, (Drosophila)
chr20_-_45976626 2.650 ZMYND8
zinc finger, MYND-type containing 8
chr22_-_29137776 2.442 NM_001005735
NM_007194
NM_145862
CHEK2


checkpoint kinase 2


chr3_-_148804122 2.257 NM_003071
NM_139048
HLTF

helicase-like transcription factor

chr2_+_191745791 2.134 GLS
glutaminase
chr9_-_84304378 1.707 TLE1
transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
chr2_+_191745546 1.685 NM_014905
GLS
glutaminase
chr14_-_74551073 1.596 ALDH6A1
aldehyde dehydrogenase 6 family, member A1
chr19_-_14640048 1.540 DNAJB1
DnaJ (Hsp40) homolog, subfamily B, member 1
chr14_-_74551159 1.453 NM_005589
ALDH6A1
aldehyde dehydrogenase 6 family, member A1
chr1_+_164528586 1.358 NM_001204961
NM_001204963
NM_002585
PBX1


pre-B-cell leukemia homeobox 1


chr2_+_191745568 1.300 GLS
glutaminase
chr10_-_72142344 1.284 NM_018205
NM_018239
LRRC20

leucine rich repeat containing 20

chr14_-_76127158 1.207 C14orf1
chromosome 14 open reading frame 1
chr17_+_7758380 1.190 NM_203411
TMEM88
transmembrane protein 88
chr2_+_200323088 1.136


chr11_+_95523809 1.117 CEP57
centrosomal protein 57kDa
chr12_+_79258517 1.113 SYT1
synaptotagmin I
chr14_-_91526912 1.098 NM_004755
NM_182398
RPS6KA5

ribosomal protein S6 kinase, 90kDa, polypeptide 5

chr13_-_78493902 1.098 NM_001201397
EDNRB
endothelin receptor type B
chr11_+_95523608 1.090 NM_001243776
NM_001243777
NM_014679
CEP57


centrosomal protein 57kDa


chr12_-_56615679 1.069 NM_005785
NM_194358
NM_194359
RNF41


ring finger protein 41


chr2_+_219135114 1.023 NM_001077399
NM_015488
PNKD

paroxysmal nonkinesigenic dyskinesia

chr3_-_129158675 1.002 MBD4
methyl-CpG binding domain protein 4
chr3_-_129158779 1.001 MBD4
methyl-CpG binding domain protein 4
chr18_-_59854179 0.998 PIGN
phosphatidylinositol glycan anchor biosynthesis, class N
chr2_+_191745912 0.997 GLS
glutaminase
chrX_-_10645726 0.948 NM_001098624
MID1
midline 1 (Opitz/BBB syndrome)
chr18_-_59854288 0.910 NM_012327
NM_176787
PIGN

phosphatidylinositol glycan anchor biosynthesis, class N

chr2_+_191745547 0.879 GLS
glutaminase
chr18_-_59854215 0.857 PIGN
phosphatidylinositol glycan anchor biosynthesis, class N
chr5_+_148737569 0.852 NM_024028
PCYOX1L
prenylcysteine oxidase 1 like
chr4_-_48782281 0.835 NM_015030
FRYL
FRY-like
chr17_+_58755158 0.812 NM_001099432
NM_017679
BCAS3

breast carcinoma amplified sequence 3

chr7_+_106809405 0.812 NM_001244262
NM_012257
HBP1

HMG-box transcription factor 1

chr3_-_129158849 0.801 NM_003925
MBD4
methyl-CpG binding domain protein 4
chr5_-_88179278 0.801 NM_001193350
NM_002397
MEF2C

myocyte enhancer factor 2C

chr1_+_150336584 0.799 RPRD2
regulation of nuclear pre-mRNA domain containing 2
chr16_+_15596122 0.776 NM_001142469
C16orf45
chromosome 16 open reading frame 45
chr10_+_102123420 0.764


chr16_+_2205809 0.757 TRAF7
TNF receptor-associated factor 7
chr4_+_6271558 0.740 NM_001145853
NM_006005
WFS1

Wolfram syndrome 1 (wolframin)

chr7_-_121784236 0.732 NM_005763
AASS
aminoadipate-semialdehyde synthase
chr1_-_149399159 0.727 NM_001024599
HIST2H2BF
histone cluster 2, H2bf
chr9_-_14313509 0.719 NFIB
nuclear factor I/B
chr14_+_76127550 0.718 NM_015072
TTLL5
tubulin tyrosine ligase-like family, member 5
chr8_+_68864341 0.716 PREX2
phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2
chr5_+_43602738 0.714 NM_012343
NNT
nicotinamide nucleotide transhydrogenase
chr1_-_221915426 0.709 DUSP10
dual specificity phosphatase 10
chr4_+_6271588 0.690 WFS1
Wolfram syndrome 1 (wolframin)
chr16_+_2205764 0.682 NM_032271
TRAF7
TNF receptor-associated factor 7
chr6_+_160183510 0.646 ACAT2
acetyl-CoA acetyltransferase 2
chr18_-_53177999 0.645 NM_001243231
TCF4
transcription factor 4
chr2_+_20646831 0.644 NM_004040
RHOB
ras homolog gene family, member B
chr16_+_69220940 0.641 NM_006750
SNTB2
syntrophin, beta 2 (dystrophin-associated protein A1, 59kDa, basic component 2)
chr5_+_43603216 0.635 NM_182977
NNT
nicotinamide nucleotide transhydrogenase
chr2_-_191878882 0.633 STAT1
signal transducer and activator of transcription 1, 91kDa
chr5_+_151151660 0.633 G3BP1
GTPase activating protein (SH3 domain) binding protein 1
chr14_+_24584321 0.632 DCAF11
DDB1 and CUL4 associated factor 11
chr15_+_43477315 0.630 NM_012142
CCNDBP1
cyclin D-type binding-protein 1
chr14_+_76127656 0.613 TTLL5
tubulin tyrosine ligase-like family, member 5
chr3_-_15839674 0.609 NM_001195098
ANKRD28
ankyrin repeat domain 28
chr12_-_56615484 0.601 NM_001242826
RNF41
ring finger protein 41
chr1_+_228645807 0.598 NM_175055
HIST3H2BB
histone cluster 3, H2bb
chr14_+_64680858 0.594 NM_182913
SYNE2
spectrin repeat containing, nuclear envelope 2
chr2_-_191878883 0.592 STAT1
signal transducer and activator of transcription 1, 91kDa
chr5_+_43603287 0.587 NNT
nicotinamide nucleotide transhydrogenase
chr3_+_111451326 0.583 NM_001134437
PHLDB2
pleckstrin homology-like domain, family B, member 2
chr8_+_6565870 0.581 NM_018361
AGPAT5
1-acylglycerol-3-phosphate O-acyltransferase 5 (lysophosphatidic acid acyltransferase, epsilon)
chr5_+_43603312 0.580 NNT
nicotinamide nucleotide transhydrogenase
chr10_+_99400469 0.573 PI4K2A
phosphatidylinositol 4-kinase type 2 alpha
chr1_-_221915458 0.571 NM_007207
NM_144729
DUSP10

dual specificity phosphatase 10

chr3_+_136581074 0.565 NCK1
NCK adaptor protein 1
chr19_+_39882018 0.556 MED29
mediator complex subunit 29
chr14_-_58764805 0.556 FLJ31306
uncharacterized LOC379025
chr1_-_221915393 0.555 DUSP10
dual specificity phosphatase 10
chr14_+_100150596 0.553 NM_006668
CYP46A1
cytochrome P450, family 46, subfamily A, polypeptide 1
chr8_-_38205652 0.548 WHSC1L1
Wolf-Hirschhorn syndrome candidate 1-like 1
chr2_+_44396061 0.545 PPM1B
protein phosphatase, Mg2+/Mn2+ dependent, 1B
chr4_+_6271605 0.538 WFS1
Wolfram syndrome 1 (wolframin)
chr12_-_113658826 0.530 NM_138451
IQCD
IQ motif containing D
chr14_+_24583979 0.526 NM_025230
DCAF11
DDB1 and CUL4 associated factor 11
chr12_+_101988746 0.516 NM_002465
NM_206819
NM_206820
NM_206821
MYBPC1



myosin binding protein C, slow type



chr14_-_75530716 0.511 NM_001107
NM_203488
ACYP1

acylphosphatase 1, erythrocyte (common) type

chr3_+_136581007 0.502 NM_006153
NCK1
NCK adaptor protein 1
chr1_+_155278677 0.500 NM_001135821
FDPS
farnesyl diphosphate synthase
chr14_+_24583905 0.500 NM_001163484
DCAF11
DDB1 and CUL4 associated factor 11
chr13_+_80055257 0.490 NM_001161407
NM_019080
NDFIP2

Nedd4 family interacting protein 2

chr1_+_155278727 0.488 FDPS
farnesyl diphosphate synthase
chr10_+_76586299 0.477 NM_012330
KAT6B
K(lysine) acetyltransferase 6B
chr18_+_47088400 0.475 NM_006033
LIPG
lipase, endothelial
chr19_+_39881950 0.473 NM_017592
MED29
mediator complex subunit 29
chr3_+_156394452 0.464 NM_001184718
TIPARP
TCDD-inducible poly(ADP-ribose) polymerase
chr2_+_28616346 0.450 FOSL2
FOS-like antigen 2
chr5_-_89705477 0.442 NM_004365
CETN3
centrin, EF-hand protein, 3
chr13_+_57734765 0.440 NM_198441
NM_001130404
NM_001130405
NM_001130406
NM_001130407
PRR20A
PRR20B
PRR20C
PRR20D
PRR20E
proline rich 20A
proline rich 20B
proline rich 20C
proline rich 20D
proline rich 20E
chr13_+_57741330 0.440 NM_198441
NM_001130404
NM_001130405
NM_001130406
NM_001130407
PRR20A
PRR20B
PRR20C
PRR20D
PRR20E
proline rich 20A
proline rich 20B
proline rich 20C
proline rich 20D
proline rich 20E
chr13_+_57728194 0.440 NM_198441
NM_001130404
NM_001130405
NM_001130406
NM_001130407
PRR20A
PRR20B
PRR20C
PRR20D
PRR20E
proline rich 20A
proline rich 20B
proline rich 20C
proline rich 20D
proline rich 20E
chr14_+_24584009 0.440 DCAF11
DDB1 and CUL4 associated factor 11
chr12_-_9102193 0.435 M6PR
mannose-6-phosphate receptor (cation dependent)
chr7_-_143599163 0.434 NM_014719
NM_001206938
FAM115A

family with sequence similarity 115, member A

chr2_-_200322699 0.422 NM_001172509
SATB2
SATB homeobox 2
chr5_+_176562084 0.415 NSD1
nuclear receptor binding SET domain protein 1
chr2_+_113033146 0.414 NM_198581
ZC3H6
zinc finger CCCH-type containing 6
chr1_-_38397417 0.408 INPP5B
inositol polyphosphate-5-phosphatase, 75kDa
chr4_-_186732208 0.403 NM_001145671
SORBS2
sorbin and SH3 domain containing 2
chr13_+_53035227 0.400 CKAP2
cytoskeleton associated protein 2
chr4_-_186300151 0.396 NM_018409
LRP2BP
LRP2 binding protein
chr10_+_14880335 0.389 HSPA14
heat shock 70kDa protein 14
chr16_+_19078916 0.386 NM_016138
COQ7
coenzyme Q7 homolog, ubiquinone (yeast)
chr10_+_14880343 0.385 HSPA14
heat shock 70kDa protein 14
chr20_-_46414636 0.384 NM_018837
SULF2
sulfatase 2
chr3_-_121553836 0.382 IQCB1
IQ motif containing B1
chr14_+_64971504 0.380 ZBTB1
zinc finger and BTB domain containing 1
chr5_-_149535420 0.380 NM_002609
PDGFRB
platelet-derived growth factor receptor, beta polypeptide
chr19_+_14640406 0.379 TECR
trans-2,3-enoyl-CoA reductase
chr18_+_20735788 0.379 NM_138375
CABLES1
Cdk5 and Abl enzyme substrate 1
chr12_+_79258448 0.378 NM_005639
SYT1
synaptotagmin I
chr10_+_124320180 0.378 NM_004406
NM_007329
NM_017579
DMBT1


deleted in malignant brain tumors 1


chr4_+_86749045 0.370 ARHGAP24
Rho GTPase activating protein 24
chr13_+_57721621 0.367 NM_198441
NM_001130404
NM_001130405
NM_001130406
NM_001130407
PRR20A
PRR20B
PRR20C
PRR20D
PRR20E
proline rich 20A
proline rich 20B
proline rich 20C
proline rich 20D
proline rich 20E
chr4_-_1722978 0.365 NM_001127266
NM_138385
TMEM129

transmembrane protein 129

chr21_-_47648685 0.365 LSS
lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
chr1_-_149783910 0.364 NM_001024599
NM_001161334
HIST2H2BF

histone cluster 2, H2bf

chr8_+_98788014 0.362 LAPTM4B
lysosomal protein transmembrane 4 beta
chr16_-_3306586 0.362 NM_000243
NM_001198536
MEFV

Mediterranean fever

chr19_+_14640403 0.359 TECR
trans-2,3-enoyl-CoA reductase
chr19_-_2041862 0.357 MKNK2
MAP kinase interacting serine/threonine kinase 2
chr3_-_121553907 0.355 NM_001023570
NM_001023571
IQCB1

IQ motif containing B1

chr13_+_80055366 0.353 NDFIP2
Nedd4 family interacting protein 2
chr19_+_49375638 0.350 NM_014330
PPP1R15A
protein phosphatase 1, regulatory subunit 15A
chr1_+_45266048 0.348 PLK3
polo-like kinase 3
chr9_-_124989755 0.348 NM_001242334
LHX6
LIM homeobox 6
chr16_+_30907927 0.341 NM_001142544
NM_001330
CTF1

cardiotrophin 1

chr1_-_182360889 0.339 GLUL
glutamate-ammonia ligase
chr19_+_49375679 0.337 PPP1R15A
protein phosphatase 1, regulatory subunit 15A
chr19_-_39881503 0.332 PAF1
Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae)
chr6_-_31830593 0.332 NM_000434
NEU1
sialidase 1 (lysosomal sialidase)
chr19_+_49375677 0.329 PPP1R15A
protein phosphatase 1, regulatory subunit 15A
chr14_-_92572888 0.328 ATXN3
ATXN8
ataxin 3
ataxin 8
chr17_-_46622274 0.325 NM_002145
HOXB2
homeobox B2
chr1_-_115323262 0.323 NM_001102396
NM_025073
SIKE1

suppressor of IKBKE 1

chrX_-_70473979 0.322 NM_201599
ZMYM3
zinc finger, MYM-type 3
chr12_+_12869818 0.321 NM_004064
CDKN1B
cyclin-dependent kinase inhibitor 1B (p27, Kip1)
chr13_+_36050885 0.319 NM_001204197
NBEA
neurobeachin
chr13_-_48987247 0.315 LPAR6
lysophosphatidic acid receptor 6
chrX_-_10588458 0.313 NM_000381
NM_033289
MID1

midline 1 (Opitz/BBB syndrome)

chr6_+_16129285 0.312 NM_013262
MYLIP
myosin regulatory light chain interacting protein
chr12_+_51442081 0.310 NM_001243689
NM_015416
LETMD1

LETM1 domain containing 1

chr16_+_67927170 0.310 NM_006742
PSKH1
protein serine kinase H1
chr11_+_13690246 0.310 FAR1
fatty acyl CoA reductase 1
chr3_+_159557745 0.307 SCHIP1
schwannomin interacting protein 1
chr7_-_7680048 0.306 RPA3
replication protein A3, 14kDa
chr2_-_96482382 0.305 LINC00342
long intergenic non-protein coding RNA 342
chr19_+_14640363 0.305 NM_138501
TECR
trans-2,3-enoyl-CoA reductase
chr2_-_211341374 0.301 NM_001136574
NM_006055
NM_001136575
LANCL1


LanC lantibiotic synthetase component C-like 1 (bacterial)


chrX_-_63425484 0.297 NM_152424
FAM123B
family with sequence similarity 123B
chr4_+_88529680 0.297 NM_014208
DSPP
dentin sialophosphoprotein
chr1_-_228645517 0.297 NM_033445
HIST3H2A
histone cluster 3, H2a
chr22_+_35695872 0.295 TOM1
target of myb1 (chicken)
chr3_+_159557649 0.294 NM_001197109
SCHIP1
schwannomin interacting protein 1
chr3_-_53164417 0.293 NM_052859
RFT1
RFT1 homolog (S. cerevisiae)
chr16_-_1876792 0.290 HAGH
hydroxyacylglutathione hydrolase
chr11_-_124981458 0.289 TMEM218
transmembrane protein 218
chr22_-_17747520 0.289 CECR3
cat eye syndrome chromosome region, candidate 3 (non-protein coding)
chrX_-_70473941 0.288 ZMYM3
zinc finger, MYM-type 3
chr1_+_120839004 0.288 NM_001100910
FAM72B
family with sequence similarity 72, member B
chr8_-_80993009 0.288 NM_001025252
TPD52
tumor protein D52
chr16_+_838645 0.286 CHTF18
CTF18, chromosome transmission fidelity factor 18 homolog (S. cerevisiae)
chr19_-_36505102 0.286 ALKBH6
alkB, alkylation repair homolog 6 (E. coli)
chr2_+_47630246 0.283 NM_000251
MSH2
mutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli)
chr11_-_19262424 0.280 NM_024680
E2F8
E2F transcription factor 8
chr11_-_27722599 0.278 NM_001143808
NM_001143809
NM_001143810
NM_001143811
BDNF



brain-derived neurotrophic factor



chr13_+_76194569 0.278 NM_005358
LMO7
LIM domain 7
chr4_-_18023358 0.272 NM_001166139
NM_153686
LCORL

ligand dependent nuclear receptor corepressor-like

chr3_+_148545587 0.270 NM_001871
CPB1
carboxypeptidase B1 (tissue)
chr1_+_150336989 0.267 NM_015203
RPRD2
regulation of nuclear pre-mRNA domain containing 2
chr16_-_1832571 0.264 SPSB3
splA/ryanodine receptor domain and SOCS box containing 3
chr1_+_155278538 0.264 NM_001135822
NM_001242824
NM_001242825
NM_002004
FDPS



farnesyl diphosphate synthase



chr1_-_143913118 0.263 NM_207418
FAM72D
family with sequence similarity 72, member D
chr11_+_13690151 0.261 NM_032228
FAR1
fatty acyl CoA reductase 1
chr2_+_47630190 0.259 MSH2
mutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli)
chr14_-_24584125 0.259 NRL
neural retina leucine zipper
chr7_-_27142301 0.259 NM_006735
HOXA2
homeobox A2
chr11_+_13690263 0.257 FAR1
fatty acyl CoA reductase 1
chr12_+_27677044 0.256 NM_001198915
NM_001198916
NM_003622
NM_177444
PPFIBP1



PTPRF interacting protein, binding protein 1 (liprin beta 1)



chr18_+_12991329 0.254 NM_032142
CEP192
centrosomal protein 192kDa
chr19_-_36505124 0.254 NM_032878
NM_198867
ALKBH6

alkB, alkylation repair homolog 6 (E. coli)

chr7_-_148725500 0.253 PDIA4
protein disulfide isomerase family A, member 4
chr6_-_31830551 0.252 NEU1
sialidase 1 (lysosomal sialidase)
chr5_+_172483285 0.251 NM_001168393
NM_001168394
NM_153607
C5orf41


chromosome 5 open reading frame 41


chr2_+_28616360 0.248 FOSL2
FOS-like antigen 2
chr13_+_27131799 0.248 NM_006646
WASF3
WAS protein family, member 3
chr19_-_39881631 0.245 NM_019088
PAF1
Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae)
chr12_+_98909331 0.245 NM_001032283
NM_001032284
NM_003276
TMPO


thymopoietin


chr15_+_43477597 0.244 CCNDBP1
cyclin D-type binding-protein 1
chr17_-_7531107 0.244 NM_133491
SAT2
spermidine/spermine N1-acetyltransferase family member 2

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
5.18 9.08e-05 GO:0065004 protein-DNA complex assembly
4.91 2.00e-04 GO:0071824 protein-DNA complex subunit organization
4.32 5.25e-04 GO:0006333 chromatin assembly or disassembly
5.23 5.52e-04 GO:0006334 nucleosome assembly
4.96 1.07e-03 GO:0031497 chromatin assembly
4.71 2.00e-03 GO:0034728 nucleosome organization
2.22 8.81e-03 GO:0051276 chromosome organization
1.66 1.90e-02 GO:0006996 organelle organization
3.79 2.71e-02 GO:0006323 DNA packaging
2.30 2.76e-02 GO:0034621 cellular macromolecular complex subunit organization

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.25 4.86e-09 GO:0043229 intracellular organelle
1.25 6.45e-09 GO:0043226 organelle
1.19 7.18e-08 GO:0044424 intracellular part
1.17 2.81e-07 GO:0005622 intracellular
5.78 3.04e-06 GO:0032993 protein-DNA complex
7.44 3.06e-06 GO:0000786 nucleosome
1.22 4.63e-05 GO:0043231 intracellular membrane-bounded organelle
1.22 5.25e-05 GO:0043227 membrane-bounded organelle
1.53 2.12e-04 GO:0043228 non-membrane-bounded organelle
1.53 2.12e-04 GO:0043232 intracellular non-membrane-bounded organelle
2.36 3.51e-04 GO:0005694 chromosome
1.30 7.27e-04 GO:0044446 intracellular organelle part
1.30 8.37e-04 GO:0044422 organelle part
2.43 1.11e-03 GO:0044427 chromosomal part
1.28 3.94e-03 GO:0005634 nucleus
1.19 5.76e-03 GO:0005737 cytoplasm
2.84 1.01e-02 GO:0000785 chromatin
1.49 1.09e-02 GO:0070013 intracellular organelle lumen
1.46 2.26e-02 GO:0043233 organelle lumen
1.43 4.04e-02 GO:0031974 membrane-enclosed lumen

Nothing significant found in function category.