Motif ID: PITX1..3.p2

Z-value: 1.825


Transcription factors associated with PITX1..3.p2:

Gene SymbolEntrez IDGene Name
PITX1 5307 paired-like homeodomain 1
PITX2 5308 paired-like homeodomain 2
PITX3 5309 paired-like homeodomain 3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.p-valuePlot
PITX2chr4_-_1115442060.242.5e-01Click!
PITX3chr10_-_1040012290.135.4e-01Click!
PITX1chr5_-_1343695710.077.4e-01Click!


Activity profile for motif PITX1..3.p2.

activity profile for motif PITX1..3.p2


Sorted Z-values histogram for motif PITX1..3.p2

Sorted Z-values for motif PITX1..3.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of PITX1..3.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr17_-_74483806 3.453 NM_001005498
RHBDF2
rhomboid 5 homolog 2 (Drosophila)
chr17_+_41158741 3.238 NM_005533
IFI35
interferon-induced protein 35
chr1_-_150738292 1.996 NM_001199739
NM_004079
CTSS

cathepsin S

chr16_+_29471206 1.954 NM_001017390
NM_177552
SULT1A4
SULT1A3
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 4
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 3
chr16_+_30210548 1.860 NM_001017390
NM_177552
SULT1A4
SULT1A3
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 4
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 3
chr17_-_40264687 1.754 NM_024119
DHX58
DEXH (Asp-Glu-X-His) box polypeptide 58
chr9_-_117156684 1.703 NM_030767
AKNA
AT-hook transcription factor
chr13_+_50069745 1.578 NM_001040443
PHF11
PHD finger protein 11
chr22_+_18632841 1.481 USP18
ubiquitin specific peptidase 18
chr13_+_50070096 1.430 PHF11
PHD finger protein 11
chrX_+_153448084 1.423 NM_000513
NM_001048181
OPN1MW
OPN1MW2
opsin 1 (cone pigments), medium-wave-sensitive
opsin 1 (cone pigments), medium-wave-sensitive 2
chrX_+_153485202 1.419 NM_000513
NM_001048181
OPN1MW
OPN1MW2
opsin 1 (cone pigments), medium-wave-sensitive
opsin 1 (cone pigments), medium-wave-sensitive 2
chr12_+_7942025 1.419 NANOG
Nanog homeobox
chr20_+_61476475 1.374 NM_080750
DPH3P1
DPH3, KTI11 homolog (S. cerevisiae) pseudogene 1
chr1_+_40713572 1.372 NM_001008740
TMCO2
transmembrane and coiled-coil domains 2
chr11_+_35198199 1.352 CD44
CD44 molecule (Indian blood group)
chr22_-_38240341 1.336 NM_138797
ANKRD54
ankyrin repeat domain 54
chr22_-_37975937 1.333 NM_006498
LGALS2
lectin, galactoside-binding, soluble, 2
chr1_+_15990300 1.314


chr6_+_31598366 1.311 PRRC2A
proline-rich coiled-coil 2A
chr19_-_17958773 1.243 JAK3
Janus kinase 3
chr6_-_32806545 1.207 NM_000544
NM_018833
TAP2

transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)

chr17_-_8113862 1.187 NM_004217
AURKB
aurora kinase B
chr14_+_74058409 1.187 NM_152331
ACOT4
acyl-CoA thioesterase 4
chr16_+_88003623 1.157 NM_001173543
BANP
BTG3 associated nuclear protein
chr2_-_74692534 1.145 NM_001146158
NM_006302
MOGS

mannosyl-oligosaccharide glucosidase

chr4_-_74964996 1.117 NM_002089
CXCL2
chemokine (C-X-C motif) ligand 2
chr22_+_18632704 1.115 NM_017414
USP18
ubiquitin specific peptidase 18
chr2_+_233470766 1.100 NM_001243252
EFHD1
EF-hand domain family, member D1
chr9_-_117160748 1.076 AKNA
AT-hook transcription factor
chr16_+_72042486 1.066 NM_001361
DHODH
dihydroorotate dehydrogenase (quinone)
chr2_-_74692501 1.045 MOGS
mannosyl-oligosaccharide glucosidase
chr22_-_42336222 1.036 NM_001110215
CENPM
centromere protein M
chr7_-_2595327 1.012 NM_152743
BRAT1
BRCA1-associated ATM activator 1
chr3_-_196242190 1.006 NM_001077657
C3orf43
chromosome 3 open reading frame 43
chr1_+_151630710 0.998 SNX27
sorting nexin family member 27
chr19_+_47840370 0.991 NM_018485
GPR77
G protein-coupled receptor 77
chr9_+_131464770 0.970 NM_013355
PKN3
protein kinase N3
chr1_-_161207879 0.956 NM_001077469
NM_001077470
NM_001077471
NM_001077472
NM_001077473
NM_001077474
NM_001077475
NM_001077476
NM_001077477
NM_001077478
NM_001077479
NM_001077480
NM_001077481
NM_001077482
NM_005122
NR1I3














nuclear receptor subfamily 1, group I, member 3














chr22_-_42343079 0.947 NM_001002876
NM_024053
CENPM

centromere protein M

chr2_+_97001463 0.938 NM_015341
NCAPH
non-SMC condensin I complex, subunit H
chr19_-_2085227 0.927 MOB3A
MOB kinase activator 3A
chr19_+_16999807 0.920 NM_003950
F2RL3
coagulation factor II (thrombin) receptor-like 3
chr10_+_91087601 0.908 NM_001549
IFIT3
interferon-induced protein with tetratricopeptide repeats 3
chr19_-_15083729 0.901 NM_005071
SLC1A6
solute carrier family 1 (high affinity aspartate/glutamate transporter), member 6
chr3_-_48130633 0.899 NM_001134364
NM_002375
NM_030885
MAP4


microtubule-associated protein 4


chr7_-_138458781 0.895 NM_130841
ATP6V0A4
ATPase, H+ transporting, lysosomal V0 subunit a4
chr1_+_16330730 0.890 NM_178840
C1orf64
chromosome 1 open reading frame 64
chr19_-_4338750 0.888 NM_001013841
NM_017720
STAP2

signal transducing adaptor family member 2

chr1_-_150738232 0.884 CTSS
cathepsin S
chr11_-_615920 0.883 IRF7
interferon regulatory factor 7
chr6_-_132022540 0.878 NM_030908
OR2A4
olfactory receptor, family 2, subfamily A, member 4
chr16_+_57673206 0.865 NM_001145774
GPR56
G protein-coupled receptor 56
chr12_+_26348268 0.856 NM_001135823
SSPN
sarcospan (Kras oncogene-associated gene)
chr15_-_89438741 0.850 NM_178232
HAPLN3
hyaluronan and proteoglycan link protein 3
chr3_-_182880463 0.849 NM_014398
LAMP3
lysosomal-associated membrane protein 3
chr12_+_7023490 0.837 NM_001975
ENO2
enolase 2 (gamma, neuronal)
chr2_+_75059781 0.829 NM_000189
HK2
hexokinase 2
chr19_-_39805975 0.826 NM_020862
LRFN1
leucine rich repeat and fibronectin type III domain containing 1
chr5_-_42993423 0.819 FLJ32255
uncharacterized LOC643977
chr13_+_27844463 0.815 NM_206827
RASL11A
RAS-like, family 11, member A
chr5_+_180415844 0.814 NM_197975
BTNL3
butyrophilin-like 3
chr4_+_89299874 0.796 NM_001165136
NM_017912
HERC6

hect domain and RLD 6

chr17_+_76210276 0.787 NM_001012270
NM_001012271
NM_001168
BIRC5


baculoviral IAP repeat containing 5


chr19_-_49401937 0.782 NM_003323
TULP2
tubby like protein 2
chr19_+_17622420 0.778 NM_012088
PGLS
6-phosphogluconolactonase
chrY_+_1405508 0.777 NM_002183
IL3RA
interleukin 3 receptor, alpha (low affinity)
chr22_-_21984274 0.776 NM_001017964
YDJC
YdjC homolog (bacterial)
chr19_-_10291056 0.766


chr22_+_22385340 0.758


chr11_+_67160775 0.757 NM_001243224
RAD9A
RAD9 homolog A (S. pombe)
chrX_+_1455508 0.756 NM_002183
IL3RA
interleukin 3 receptor, alpha (low affinity)
chr10_+_91092238 0.755 NM_001031683
IFIT3
interferon-induced protein with tetratricopeptide repeats 3
chr1_+_247581350 0.755 NM_001127462
NM_001243133
NM_004895
NM_183395
NLRP3



NLR family, pyrin domain containing 3



chr19_-_51531283 0.755 NM_001167605
NM_006853
KLK11

kallikrein-related peptidase 11

chr11_+_118955569 0.752 NM_000190
HMBS
hydroxymethylbilane synthase
chr12_-_123834984 0.746 NM_001167856
NM_018183
SBNO1

strawberry notch homolog 1 (Drosophila)

chr1_-_150738255 0.745 CTSS
cathepsin S
chr19_+_4488690 0.743 HDGFRP2
hepatoma-derived growth factor-related protein 2
chr11_+_73661363 0.743 NM_153614
DNAJB13
DnaJ (Hsp40) homolog, subfamily B, member 13
chr9_-_74675498 0.739 NM_001128618
C9orf57
chromosome 9 open reading frame 57
chr9_-_136214557 0.731 MED22
mediator complex subunit 22
chr5_+_81601165 0.730 NM_001017971
ATP6AP1L
ATPase, H+ transporting, lysosomal accessory protein 1-like
chr20_+_33134691 0.730 NM_181509
MAP1LC3A
microtubule-associated protein 1 light chain 3 alpha
chr22_+_32753853 0.725 NM_001098535
RFPL3
ret finger protein-like 3
chr19_+_6135650 0.724 NM_030924
ACSBG2
acyl-CoA synthetase bubblegum family member 2
chr15_-_41836442 0.723 RPAP1
RNA polymerase II associated protein 1
chr2_-_27357519 0.719 NM_013388
PREB
prolactin regulatory element binding
chr11_-_615998 0.718 NM_001572
NM_004029
IRF7

interferon regulatory factor 7

chr10_+_91174438 0.717 IFIT5
interferon-induced protein with tetratricopeptide repeats 5
chr17_-_41174431 0.713 NM_006373
VAT1
vesicle amine transport protein 1 homolog (T. californica)
chr10_+_91174303 0.707 NM_012420
IFIT5
interferon-induced protein with tetratricopeptide repeats 5
chr17_-_4607431 0.705 NM_014389
PELP1
proline, glutamate and leucine rich protein 1
chr19_-_7553867 0.704 NM_080662
PEX11G
peroxisomal biogenesis factor 11 gamma
chr2_+_219575507 0.694 NM_014640
TTLL4
tubulin tyrosine ligase-like family, member 4
chr19_-_39235113 0.692 NM_144691
CAPN12
calpain 12
chr10_+_71029755 0.692 NM_033497
NM_033498
NM_033500
HK1


hexokinase 1


chr4_+_124320664 0.686 NM_005841
SPRY1
sprouty homolog 1, antagonist of FGF signaling (Drosophila)
chr22_-_32589386 0.685 NM_006605
RFPL2
ret finger protein-like 2
chr1_-_8003224 0.684 NM_001561
TNFRSF9
tumor necrosis factor receptor superfamily, member 9
chr15_-_41836458 0.681 NM_015540
RPAP1
RNA polymerase II associated protein 1
chr19_-_50980002 0.680 NM_138411
FAM71E1
family with sequence similarity 71, member E1
chr4_-_170924911 0.680 NM_001009554
MFAP3L
microfibrillar-associated protein 3-like
chr19_+_12863406 0.677 NM_017682
BEST2
bestrophin 2
chr4_+_57371374 0.665 NM_206919
ARL9
ADP-ribosylation factor-like 9
chr16_+_230332 0.665 NM_005331
HBQ1
hemoglobin, theta 1
chr6_-_31619481 0.661


chr2_+_27255745 0.660 NM_001083590
NM_017727
TMEM214

transmembrane protein 214

chr19_+_14551080 0.658 NM_213560
PKN1
protein kinase N1
chr22_-_43036606 0.653 NM_001165877
ATP5L2
ATP synthase, H+ transporting, mitochondrial Fo complex, subunit G2
chr2_-_27357515 0.652 PREB
prolactin regulatory element binding
chr19_+_14551087 0.648 PKN1
protein kinase N1
chr12_+_54892567 0.647 NM_001184976
NCKAP1L
NCK-associated protein 1-like
chr19_-_54567034 0.644 NM_198481
VSTM1
V-set and transmembrane domain containing 1
chr1_-_23342342 0.643 NM_001242521
LOC729059
uncharacterized LOC729059
chr19_+_49956492 0.638 ALDH16A1
aldehyde dehydrogenase 16 family, member A1
chr2_-_27357486 0.636 PREB
prolactin regulatory element binding
chr7_-_97501680 0.630 ASNS
asparagine synthetase (glutamine-hydrolyzing)
chr19_+_55014012 0.629 NM_002288
NM_021270
LAIR2

leukocyte-associated immunoglobulin-like receptor 2

chr1_+_12079298 0.629 NM_021933
MIIP
migration and invasion inhibitory protein
chr6_-_28891736 0.625 NM_006510
TRIM27
tripartite motif containing 27
chr19_+_14551052 0.625 PKN1
protein kinase N1
chr11_-_62420720 0.624 NM_030628
INTS5
integrator complex subunit 5
chr12_+_57881735 0.612 NM_004990
MARS
methionyl-tRNA synthetase
chr19_+_41620336 0.603 NM_000774
CYP2F1
cytochrome P450, family 2, subfamily F, polypeptide 1
chr6_-_33547833 0.601 BAK1
BCL2-antagonist/killer 1
chrX_+_9431314 0.598 NM_001139466
NM_001139467
NM_001139468
TBL1X


transducin (beta)-like 1X-linked


chr8_-_145642250 0.597 NM_130849
SLC39A4
solute carrier family 39 (zinc transporter), member 4
chr22_-_17680485 0.597 NM_177405
CECR1
cat eye syndrome chromosome region, candidate 1
chr22_-_38240246 0.590 ANKRD54
ankyrin repeat domain 54
chr17_-_56358118 0.589 MPO
myeloperoxidase
chr6_+_26020677 0.588 NM_003529
HIST1H3A
histone cluster 1, H3a
chr1_+_150293916 0.586 NM_004698
PRPF3
PRP3 pre-mRNA processing factor 3 homolog (S. cerevisiae)
chrX_-_31090158 0.584 NM_031894
FTHL17
ferritin, heavy polypeptide-like 17
chr6_-_33548017 0.583 NM_001188
BAK1
BCL2-antagonist/killer 1
chr2_+_39005326 0.582 NM_024775
GEMIN6
gem (nuclear organelle) associated protein 6
chr19_-_2096280 0.582 MOB3A
MOB kinase activator 3A
chr12_-_123594974 0.581 NM_020845
PITPNM2
phosphatidylinositol transfer protein, membrane-associated 2
chr12_+_57881853 0.581 MARS
methionyl-tRNA synthetase
chr7_-_97501737 0.581 NM_001178075
NM_001178076
NM_001673
NM_183356
ASNS



asparagine synthetase (glutamine-hydrolyzing)



chr2_-_74692409 0.576 MOGS
mannosyl-oligosaccharide glucosidase
chr20_-_3996035 0.575 NM_007219
NM_001134337
NM_001134338
RNF24


ring finger protein 24


chr1_+_28655512 0.575 NM_001127350
NM_017638
MED18

mediator complex subunit 18

chr7_-_140302311 0.574 NM_015689
DENND2A
DENN/MADD domain containing 2A
chr7_-_100858312 0.567 PLOD3
procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3
chr16_+_67001377 0.564 NM_001185176
CES3
carboxylesterase 3
chr3_-_139258531 0.559 NM_001130992
NM_001130993
NM_002899
RBP1


retinol binding protein 1, cellular


chr19_+_38810751 0.558 KCNK6
potassium channel, subfamily K, member 6
chr9_-_35115844 0.558 NM_025182
FAM214B
family with sequence similarity 214, member B
chr19_+_49956472 0.557 NM_001145396
NM_153329
ALDH16A1

aldehyde dehydrogenase 16 family, member A1

chr10_-_47173917 0.555 NM_001040084
NM_001098845
ANXA8L2
ANXA8
ANXA8L1
annexin A8-like 2
annexin A8
annexin A8-like 1
chr16_+_3405888 0.554 NM_012368
OR2C1
olfactory receptor, family 2, subfamily C, member 1
chr19_-_2096263 0.550 NM_130807
MOB3A
MOB kinase activator 3A
chr12_+_52416615 0.549 NM_001202233
NR4A1
nuclear receptor subfamily 4, group A, member 1
chr1_+_11724148 0.549 NM_018438
FBXO6
F-box protein 6
chr13_-_80915041 0.547 NM_005842
SPRY2
sprouty homolog 2 (Drosophila)
chr14_-_106452693 0.545 IGHG1
immunoglobulin heavy constant gamma 1 (G1m marker)
chr19_+_41768368 0.542 NM_144732
HNRNPUL1
heterogeneous nuclear ribonucleoprotein U-like 1
chr5_-_150467220 0.540 NM_001252390
TNIP1
TNFAIP3 interacting protein 1
chr1_-_154580481 0.539 ADAR
adenosine deaminase, RNA-specific
chr1_-_154580632 0.534 ADAR
adenosine deaminase, RNA-specific
chr15_+_71433787 0.533 NM_024817
THSD4
thrombospondin, type I, domain containing 4
chr19_+_15904760 0.524 NM_001004466
OR10H5
olfactory receptor, family 10, subfamily H, member 5
chr2_-_27357288 0.522 PREB
prolactin regulatory element binding
chr2_-_97652300 0.521 NM_001122646
FAM178B
family with sequence similarity 178, member B
chr19_+_17622445 0.518 PGLS
6-phosphogluconolactonase
chr6_-_32806452 0.517 TAP2
transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)
chr3_+_127317212 0.516 NM_004526
MCM2
minichromosome maintenance complex component 2
chr7_+_76054251 0.514 NM_001110354
ZP3
zona pellucida glycoprotein 3 (sperm receptor)
chr17_-_8151353 0.513 CTC1
CTS telomere maintenance complex component 1
chr17_-_4046190 0.512


chr1_-_154578775 0.511 NM_001193495
ADAR
adenosine deaminase, RNA-specific
chr5_-_156486128 0.511 HAVCR1
hepatitis A virus cellular receptor 1
chr15_-_72501017 0.511 PKM2
pyruvate kinase, muscle
chr1_-_154580677 0.510 NM_001111
NM_015840
NM_015841
ADAR


adenosine deaminase, RNA-specific


chr19_+_3136026 0.509 NM_002068
GNA15
guanine nucleotide binding protein (G protein), alpha 15 (Gq class)
chr16_-_28634873 0.506 NM_177536
SULT1A1
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
chr7_-_5821250 0.505 NM_207111
NM_207116
RNF216

ring finger protein 216

chr7_+_141695678 0.504 NM_004668
MGAM
maltase-glucoamylase (alpha-glucosidase)
chr7_-_2595112 0.499 BRAT1
BRCA1-associated ATM activator 1
chr13_+_27844936 0.498 RASL11A
RAS-like, family 11, member A
chr8_+_125985538 0.496 NM_152412
ZNF572
zinc finger protein 572
chr5_+_54320083 0.495 NM_002104
GZMK
granzyme K (granzyme 3; tryptase II)
chrX_+_38211735 0.493 NM_000531
OTC
ornithine carbamoyltransferase
chr9_-_130540911 0.492 NM_170600
SH2D3C
SH2 domain containing 3C
chr16_+_50321822 0.492 NM_001114
ADCY7
adenylate cyclase 7
chr19_-_15918848 0.491 NM_013940
OR10H1
olfactory receptor, family 10, subfamily H, member 1
chr16_-_85722587 0.491 NM_016095
GINS2
GINS complex subunit 2 (Psf2 homolog)
chr8_+_7738908 0.490 NM_018661
DEFB103B
defensin, beta 103B
chr19_+_58180302 0.489 NM_152677
ZSCAN4
zinc finger and SCAN domain containing 4
chr19_-_50400131 0.489 NM_152899
IL4I1
interleukin 4 induced 1
chr16_+_66995099 0.488 NM_001185177
NM_024922
CES3

carboxylesterase 3

chr19_+_44084695 0.487 NM_001193622
LOC390940
uncharacterized protein ENSP00000244321
chr19_-_47197162 0.486 PRKD2
protein kinase D2
chr13_+_100229365 0.486


chr7_+_73624252 0.484 LAT2
linker for activation of T cells family, member 2
chr15_-_90222572 0.484 NM_001145311
NM_002666
PLIN1

perilipin 1

chr12_-_49999259 0.484 NM_032130
FAM186B
family with sequence similarity 186, member B
chr7_+_5920426 0.479 NM_001097622
OCM
oncomodulin
chr3_+_127317271 0.479 MCM2
minichromosome maintenance complex component 2

Gene Ontology Analysis

Nothing significant found in process category.

Nothing significant found in compartment category.

Nothing significant found in function category.