Motif ID: POU1F1.p2

Z-value: 1.040


Transcription factors associated with POU1F1.p2:

Gene SymbolEntrez IDGene Name
POU1F1 5449 POU class 1 homeobox 1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.p-valuePlot
POU1F1chr3_-_873256110.395.4e-02Click!


Activity profile for motif POU1F1.p2.

activity profile for motif POU1F1.p2


Sorted Z-values histogram for motif POU1F1.p2

Sorted Z-values for motif POU1F1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of POU1F1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr1_-_173020011 5.587 NM_005092
TNFSF18
tumor necrosis factor (ligand) superfamily, member 18
chr1_+_101185195 4.356 NM_001078
NM_001199834
NM_080682
VCAM1


vascular cell adhesion molecule 1


chr4_-_76944585 3.477 NM_001565
CXCL10
chemokine (C-X-C motif) ligand 10
chr12_+_113344811 2.704 OAS1
2'-5'-oligoadenylate synthetase 1, 40/46kDa
chr11_-_128457452 2.319 NM_001143820
ETS1
v-ets erythroblastosis virus E26 oncogene homolog 1 (avian)
chr15_+_66694216 2.140 MAP2K1
mitogen-activated protein kinase kinase 1
chr12_+_113344738 1.965 NM_001032409
NM_002534
NM_016816
OAS1


2'-5'-oligoadenylate synthetase 1, 40/46kDa


chr4_-_70080448 1.850 NM_001073
UGT2B11
UGT2B10
UDP glucuronosyltransferase 2 family, polypeptide B11
UDP glucuronosyltransferase 2 family, polypeptide B10
chr2_+_102770401 1.830 NM_000877
IL1R1
interleukin 1 receptor, type I
chr12_+_78225068 1.824 NM_014903
NAV3
neuron navigator 3
chr2_+_231281470 1.756 NM_001206704
SP100
SP100 nuclear antigen
chr3_+_97158453 1.724 NM_173655
EPHA6
EPH receptor A6
chr13_-_20110884 1.579 NM_001141968
NM_130785
NM_199254
TPTE2


transmembrane phosphoinositide 3-phosphatase and tensin homolog 2


chr3_-_169487602 1.570 NM_032487
ARPM1
actin related protein M1
chr2_+_36923832 1.544 NM_001177969
NM_001177970
NM_001177971
NM_001177972
NM_053276
VIT




vitrin




chr5_+_54320083 1.501 NM_002104
GZMK
granzyme K (granzyme 3; tryptase II)
chr18_+_61554938 1.481 NM_001143818
NM_002575
SERPINB2

serpin peptidase inhibitor, clade B (ovalbumin), member 2

chr1_-_57045214 1.476 PPAP2B
phosphatidic acid phosphatase type 2B
chr16_+_57050985 1.443 NM_032206
NLRC5
NLR family, CARD domain containing 5
chr11_-_8832881 1.439 NM_139157
ST5
suppression of tumorigenicity 5
chr20_-_45061554 1.381 ELMO2
engulfment and cell motility 2
chr15_-_55562483 1.363 NM_183234
NM_004580
RAB27A

RAB27A, member RAS oncogene family

chr12_+_45686465 1.308 NM_001142678
ANO6
anoctamin 6
chr7_-_139763520 1.295 NM_022750
PARP12
poly (ADP-ribose) polymerase family, member 12
chr11_+_59807747 1.288 NM_173801
PLAC1L
placenta-specific 1-like
chr1_-_89591685 1.282 NM_004120
GBP2
guanylate binding protein 2, interferon-inducible
chr10_+_111765725 1.278 NM_019903
ADD3
adducin 3 (gamma)
chr2_+_152214105 1.272 NM_007115
TNFAIP6
tumor necrosis factor, alpha-induced protein 6
chr1_+_196857143 1.261 NM_001201550
NM_001201551
NM_006684
CFHR4


complement factor H-related 4


chr2_+_102953716 1.256 NM_003856
IL1RL1
interleukin 1 receptor-like 1
chr6_+_64286348 1.254 PTP4A1
protein tyrosine phosphatase type IVA, member 1
chr7_-_115670774 1.252 TFEC
transcription factor EC
chr3_-_123339178 1.189 MYLK
myosin light chain kinase
chr21_+_43710190 1.160 ABCG1
ATP-binding cassette, sub-family G (WHITE), member 1
chr14_-_64749530 1.126 NM_001214902
NM_001214903
ESR2

estrogen receptor 2 (ER beta)

chr5_-_58295758 1.100 NM_001197223
PDE4D
phosphodiesterase 4D, cAMP-specific
chrX_+_30261847 1.097 NM_002363
NM_177415
MAGEB1

melanoma antigen family B, 1

chr3_-_27498244 1.084 NM_003615
SLC4A7
solute carrier family 4, sodium bicarbonate cotransporter, member 7
chr1_-_207095198 1.077 NM_001193338
NM_001142473
NM_005449
FAIM3


Fas apoptotic inhibitory molecule 3


chr17_+_46985720 1.055 NM_023079
UBE2Z
ubiquitin-conjugating enzyme E2Z
chr1_+_172389827 1.052 NM_139240
C1orf105
chromosome 1 open reading frame 105
chr1_-_101360405 1.047 NM_001033025
NM_001439
EXTL2

exostoses (multiple)-like 2

chr2_-_231090443 1.042 NM_001185015
SP110
SP110 nuclear body protein
chr11_+_69455837 0.987 NM_053056
CCND1
cyclin D1
chr7_+_142919129 0.921 NM_176882
TAS2R40
taste receptor, type 2, member 40
chr12_-_45307710 0.896 NM_001145110
NELL2
NEL-like 2 (chicken)
chr9_+_96846710 0.877 NM_001253829
NM_152422
PTPDC1

protein tyrosine phosphatase domain containing 1

chr8_-_37756971 0.840 NM_001002814
NM_025151
RAB11FIP1

RAB11 family interacting protein 1 (class I)

chr5_-_41213513 0.834 NM_000065
C6
complement component 6
chr2_+_36923902 0.817 VIT
vitrin
chr1_-_183274008 0.811 NM_170706
NMNAT2
nicotinamide nucleotide adenylyltransferase 2
chr13_+_97874704 0.805 MBNL2
muscleblind-like 2 (Drosophila)
chr1_-_57045235 0.796 NM_003713
PPAP2B
phosphatidic acid phosphatase type 2B
chr3_-_138478184 0.776 NM_006219
PIK3CB
phosphoinositide-3-kinase, catalytic, beta polypeptide
chr4_-_70518964 0.767 NM_001252274
NM_001252275
NM_006798
UGT2A1


UDP glucuronosyltransferase 2 family, polypeptide A1, complex locus


chr6_+_29913400 0.753


chr1_+_171154387 0.750 NM_001460
FMO2
flavin containing monooxygenase 2 (non-functional)
chr17_-_39165343 0.745 NM_031958
KRTAP3-1
keratin associated protein 3-1
chr1_-_169703178 0.729 NM_000450
SELE
selectin E
chr5_-_59783885 0.722 NM_001165899
PDE4D
phosphodiesterase 4D, cAMP-specific
chr19_+_7030593 0.719 NM_001136507
MBD3L5
methyl-CpG binding domain protein 3-like 5
chr6_-_22297729 0.713 NM_000948
PRL
prolactin
chrX_+_7810302 0.707 NM_013452
VCX
variable charge, X-linked
chr4_+_100495972 0.706 MTTP
microsomal triglyceride transfer protein
chr2_-_27362277 0.701 NM_178553
C2orf53
chromosome 2 open reading frame 53
chr4_+_36283243 0.696 NM_001136536
DTHD1
death domain containing 1
chr22_+_24033047 0.690 NM_153615
RGL4
ral guanine nucleotide dissociation stimulator-like 4
chr6_+_26368405 0.664 NM_001197246
BTN3A2
butyrophilin, subfamily 3, member A2
chr1_+_152881022 0.658 NM_005547
IVL
involucrin
chr11_-_36619776 0.655 NM_000536
NM_001243785
NM_001243786
RAG2


recombination activating gene 2


chr20_+_123230 0.647 NM_030931
DEFB126
defensin, beta 126
chr9_-_21368005 0.642 NM_006900
IFNA1
IFNA13
interferon, alpha 1
interferon, alpha 13
chr4_-_139163222 0.638 NM_014331
SLC7A11
solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
chr18_+_59157774 0.634 NM_031891
CDH20
cadherin 20, type 2
chr19_+_39971051 0.621 NM_001001563
TIMM50
translocase of inner mitochondrial membrane 50 homolog (S. cerevisiae)
chr3_-_121379757 0.608 NM_005335
HCLS1
hematopoietic cell-specific Lyn substrate 1
chr8_-_134115309 0.605 NM_001045556
NM_001045557
SLA

Src-like-adaptor

chr3_-_121379701 0.605 HCLS1
hematopoietic cell-specific Lyn substrate 1
chr11_+_71709951 0.594 NM_001039659
NM_001039660
NM_173044
NM_005699
NM_173042
IL18BP




interleukin 18 binding protein




chr21_-_31538970 0.587 NM_012131
CLDN17
claudin 17
chr10_+_91092238 0.584 NM_001031683
IFIT3
interferon-induced protein with tetratricopeptide repeats 3
chr6_+_37225506 0.576 NM_017772
TBC1D22B
TBC1 domain family, member 22B
chr11_-_16430425 0.574 NM_001145811
SOX6
SRY (sex determining region Y)-box 6
chr14_-_101036130 0.566 NM_020836
BEGAIN
brain-enriched guanylate kinase-associated homolog (rat)
chr4_+_74347461 0.558 NM_001133
AFM
afamin
chr12_-_87232635 0.554 NM_013244
MGAT4C
mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme C (putative)
chr14_+_21525980 0.554 NM_138331
RNASE8
ribonuclease, RNase A family, 8
chr16_+_67381252 0.540 NM_001161575
LRRC36
leucine rich repeat containing 36
chr2_+_182850550 0.540 NM_001080545
PPP1R1C
protein phosphatase 1, regulatory (inhibitor) subunit 1C
chr9_+_111624545 0.538 NM_006687
ACTL7A
actin-like 7A
chr7_+_107110501 0.537 NM_005295
GPR22
G protein-coupled receptor 22
chr5_+_140809957 0.536 PCDHGA12
protocadherin gamma subfamily A, 12
chr1_+_147374945 0.526 NM_005267
GJA8
gap junction protein, alpha 8, 50kDa
chr4_-_103998169 0.523 NM_178833
SLC9B2
solute carrier family 9, subfamily B (cation proton antiporter 2), member 2
chr11_-_7847518 0.517 NM_153445
OR5P3
olfactory receptor, family 5, subfamily P, member 3
chr3_+_128779609 0.515 NM_000174
GP9
glycoprotein IX (platelet)
chr4_-_80994309 0.509 NM_001145794
NM_058172
ANTXR2

anthrax toxin receptor 2

chr2_+_167744996 0.509 NM_001079810
NM_001199143
NM_152381
XIRP2


xin actin-binding repeat containing 2


chr7_-_45018559 0.503 MYO1G
myosin IG
chr15_+_85666291 0.501 PDE8A
phosphodiesterase 8A
chr3_+_148447966 0.501 NM_032049
AGTR1
angiotensin II receptor, type 1
chr9_-_70178814 0.501 NM_001126334
FOXD4L5
forkhead box D4-like 5
chr12_-_23737507 0.500 NM_178010
SOX5
SRY (sex determining region Y)-box 5
chr3_+_38347426 0.496 NM_004803
SLC22A14
solute carrier family 22, member 14
chr13_+_97928414 0.495 MBNL2
muscleblind-like 2 (Drosophila)
chr2_+_166095911 0.492 NM_001040142
SCN2A
sodium channel, voltage-gated, type II, alpha subunit
chr12_-_10151689 0.490 NM_001099431
NM_016509
CLEC1B

C-type lectin domain family 1, member B

chrY_-_1281526 0.489 NM_001012288
NM_022148
CRLF2

cytokine receptor-like factor 2

chr3_+_108855560 0.485 FLJ22763
uncharacterized LOC401081
chr12_-_62586547 0.484 NM_178539
FAM19A2
family with sequence similarity 19 (chemokine (C-C motif)-like), member A2
chrX_-_1331526 0.484 NM_001012288
NM_022148
CRLF2

cytokine receptor-like factor 2

chr20_+_138121 0.483 NM_139074
DEFB127
defensin, beta 127
chr3_-_194188967 0.482 NM_024524
ATP13A3
ATPase type 13A3
chr1_-_100643770 0.482 NM_144620
LRRC39
leucine rich repeat containing 39
chr11_+_124824076 0.478 CCDC15
coiled-coil domain containing 15
chr5_-_93077196 0.475 NM_153216
POU5F2
POU domain class 5, transcription factor 2
chr17_+_33448597 0.474 NM_017559
FNDC8
fibronectin type III domain containing 8
chr16_-_28620648 0.473 NM_177530
NM_177534
SULT1A1

sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1

chr3_+_100428133 0.471 NM_001007565
NM_001195479
NM_006070
TFG


TRK-fused gene


chr9_-_70429730 0.470 NM_001099279
NM_199244
FOXD4L2
FOXD4L4
forkhead box D4-like 2
forkhead box D4-like 4
chr19_-_3969734 0.468 NM_001348
DAPK3
death-associated protein kinase 3
chr17_+_78356710 0.464 RNF213
ring finger protein 213
chr10_+_124670216 0.461 NM_001029888
FAM24A
family with sequence similarity 24, member A
chr2_-_175712276 0.460 NM_001206602
CHN1
chimerin (chimaerin) 1
chr17_-_38978824 0.460 NM_000421
KRT10
keratin 10
chr2_-_88427535 0.457 NM_001443
FABP1
fatty acid binding protein 1, liver
chr11_+_69061599 0.454 NM_138768
MYEOV
myeloma overexpressed (in a subset of t(11;14) positive multiple myelomas)
chr17_+_3118911 0.454 NM_014565
OR1A1
olfactory receptor, family 1, subfamily A, member 1
chr1_-_102462789 0.445 NM_058170
OLFM3
olfactomedin 3
chr3_+_97887543 0.433 NM_001005515
OR5H15
olfactory receptor, family 5, subfamily H, member 15
chr7_-_45018677 0.432 NM_033054
MYO1G
myosin IG
chr9_+_42717233 0.429 NM_001099279
NM_199244
FOXD4L2
FOXD4L4
forkhead box D4-like 2
forkhead box D4-like 4
chrX_+_41548225 0.428 NM_001097579
NM_005300
GPR34

G protein-coupled receptor 34

chr2_-_174767282 0.426


chr3_+_12392993 0.426 NM_015869
PPARG
peroxisome proliferator-activated receptor gamma
chr4_-_100273831 0.424 NM_000669
ADH1C
alcohol dehydrogenase 1C (class I), gamma polypeptide
chr5_-_24645084 0.424 NM_006727
CDH10
cadherin 10, type 2 (T2-cadherin)
chr4_+_70894129 0.419 NM_000200
HTN3
histatin 3
chrX_+_144908927 0.412 NM_004709
CXorf1
chromosome X open reading frame 1
chr4_-_47983430 0.408 NM_001142564
CNGA1
cyclic nucleotide gated channel alpha 1
chr8_+_67039130 0.408 NM_033058
NM_184085
NM_184086
NM_184087
TRIM55



tripartite motif containing 55



chr7_+_102023016 0.408


chr12_+_113376001 0.407 OAS3
2'-5'-oligoadenylate synthetase 3, 100kDa
chr4_+_175839508 0.404 NM_001130703
NM_001130704
NM_001130705
NM_014269
ADAM29



ADAM metallopeptidase domain 29



chr7_+_143412938 0.402 NM_001130026
FAM115C
family with sequence similarity 115, member C
chr6_+_144185572 0.402 NM_001013623
C6orf94
chromosome 6 open reading frame 94
chr4_+_95376396 0.402 PDLIM5
PDZ and LIM domain 5
chr4_+_71263598 0.399 NM_021225
PROL1
proline rich, lacrimal 1
chr15_-_89089792 0.398 NM_001144074
NM_017996
DET1

de-etiolated homolog 1 (Arabidopsis)

chr15_+_71839540 0.395 THSD4
thrombospondin, type I, domain containing 4
chr4_-_83347222 0.394 HNRPDL
heterogeneous nuclear ribonucleoprotein D-like
chr17_-_32690180 0.391 NM_002981
CCL1
chemokine (C-C motif) ligand 1
chrX_+_108779009 0.391 NM_018698
NXT2
nuclear transport factor 2-like export factor 2
chr3_+_121774208 0.390 NM_001206924
NM_001206925
NM_175862
CD86


CD86 molecule


chr5_-_158634641 0.389 NM_001199382
RNF145
ring finger protein 145
chr5_+_140743755 0.388 NM_018918
NM_032054
PCDHGA5

protocadherin gamma subfamily A, 5

chr2_-_21225640 0.387 APOB
apolipoprotein B (including Ag(x) antigen)
chr1_-_28241233 0.387 NM_002946
RPA2
replication protein A2, 32kDa
chr12_-_21487831 0.387 NM_021094
SLCO1A2
solute carrier organic anion transporter family, member 1A2
chr6_-_116447225 0.385 NM_000493
COL10A1
collagen, type X, alpha 1
chrY_+_1351570 0.384 NM_001161530
NM_172247
CSF2RA

colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage)

chr2_-_178753464 0.379 NM_001077196
PDE11A
phosphodiesterase 11A
chr11_-_18956545 0.377 NM_147199
MRGPRX1
MAS-related GPR, member X1
chr1_-_51787881 0.375 NM_001080494
TTC39A
tetratricopeptide repeat domain 39A
chr22_-_45608346 0.375 NM_015264
KIAA0930
KIAA0930
chr11_+_30252562 0.374 NM_000510
NM_001018080
FSHB

follicle stimulating hormone, beta polypeptide

chr4_-_118006731 0.372 NM_152402
TRAM1L1
translocation associated membrane protein 1-like 1
chr15_-_58306185 0.372 NM_170697
ALDH1A2
aldehyde dehydrogenase 1 family, member A2
chr6_+_31539875 0.370 NM_001159740
LTA
lymphotoxin alpha (TNF superfamily, member 1)
chr8_+_132991171 0.367 EFR3A
EFR3 homolog A (S. cerevisiae)
chr16_-_48266181 0.365 NM_033151
ABCC11
ATP-binding cassette, sub-family C (CFTR/MRP), member 11
chr8_-_101936521 0.365 YWHAZ
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide
chr16_+_7382750 0.364 NM_145891
NM_145892
NM_145893
RBFOX1


RNA binding protein, fox-1 homolog (C. elegans) 1


chrX_+_1401570 0.364 NM_001161530
NM_172247
CSF2RA

colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage)

chr1_+_46379258 0.362 MAST2
microtubule associated serine/threonine kinase 2
chr8_+_24151579 0.361 NM_014265
NM_021777
ADAM28

ADAM metallopeptidase domain 28

chr1_+_211519705 0.361 NM_145759
TRAF5
TNF receptor-associated factor 5
chr4_-_46125929 0.359 NM_173536
GABRG1
gamma-aminobutyric acid (GABA) A receptor, gamma 1
chr18_-_64271215 0.359 NM_021153
CDH19
cadherin 19, type 2
chr12_-_11150473 0.358 NM_176889
TAS2R20
taste receptor, type 2, member 20
chr7_+_123565908 0.357 NM_001174045
NM_001174046
SPAM1

sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding)

chr7_-_14880954 0.353 NM_004080
NM_145695
DGKB

diacylglycerol kinase, beta 90kDa

chr2_-_77749335 0.352 NM_001134745
NM_024993
LRRTM4

leucine rich repeat transmembrane neuronal 4

chr1_+_148577356 0.352 NM_001102663
NBPF15
NBPF16
neuroblastoma breakpoint family, member 15
neuroblastoma breakpoint family, member 16
chr4_+_119948554 0.351 SYNPO2
synaptopodin 2
chr5_-_95748688 0.350 NM_001177876
PCSK1
proprotein convertase subtilisin/kexin type 1
chr16_-_28621279 0.349 NM_001055
NM_177529
SULT1A1

sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1

chr21_-_33074101 0.349 SCAF4
SR-related CTD-associated factor 4
chr1_+_148739441 0.348 NM_001102663
NBPF15
NBPF8
NBPF16
neuroblastoma breakpoint family, member 15
neuroblastoma breakpoint family, member 8
neuroblastoma breakpoint family, member 16
chr15_-_50411405 0.347 NM_024837
ATP8B4
ATPase, class I, type 8B, member 4
chr15_-_43910959 0.345 NM_153700
STRC
stereocilin
chr3_+_151488214 0.344 LOC201651
arylacetamide deacetylase (esterase) pseudogene
chr5_+_70944968 0.344 MCCC2
methylcrotonoyl-CoA carboxylase 2 (beta)
chr6_+_105404922 0.343 NM_001004317
LIN28B
lin-28 homolog B (C. elegans)
chr3_+_46395224 0.343 NM_001123041
NM_001123396
CCR2

chemokine (C-C motif) receptor 2

chr17_-_63009302 0.335 GNA13
guanine nucleotide binding protein (G protein), alpha 13
chr7_-_141957846 0.332 NM_001001317
PRSS58
protease, serine, 58
chr3_-_170744458 0.332 SLC2A2
solute carrier family 2 (facilitated glucose transporter), member 2
chr3_-_167191808 0.330 NM_006217
SERPINI2
serpin peptidase inhibitor, clade I (pancpin), member 2
chr21_-_15579243 0.330 NM_198996
LIPI
lipase, member I

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
2.36 1.47e-07 GO:0006955 immune response
1.94 2.86e-06 GO:0002376 immune system process
2.08 6.05e-05 GO:0006952 defense response
1.25 2.61e-03 GO:0050896 response to stimulus
2.38 6.23e-03 GO:0045087 innate immune response
3.35 1.13e-02 GO:0006805 xenobiotic metabolic process
3.35 1.13e-02 GO:0071466 cellular response to xenobiotic stimulus
3.33 1.26e-02 GO:0009410 response to xenobiotic stimulus
3.54 3.43e-02 GO:0002768 immune response-regulating cell surface receptor signaling pathway
2.10 4.82e-02 GO:0050776 regulation of immune response

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.39 5.75e-06 GO:0071944 cell periphery
1.38 1.90e-05 GO:0005886 plasma membrane
1.57 5.48e-05 GO:0005576 extracellular region
1.91 2.10e-04 GO:0005626 insoluble fraction
1.91 3.34e-04 GO:0005624 membrane fraction
1.47 1.63e-03 GO:0044459 plasma membrane part
10.61 2.48e-03 GO:0042613 MHC class II protein complex
1.65 6.90e-03 GO:0000267 cell fraction
1.61 2.96e-02 GO:0044421 extracellular region part

Nothing significant found in function category.