Motif ID: PRRX1,2.p2

Z-value: 0.982


Transcription factors associated with PRRX1,2.p2:

Gene SymbolEntrez IDGene Name
PRRX1 5396 paired related homeobox 1
PRRX2 51450 paired related homeobox 2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.p-valuePlot
PRRX2chr9_+_132428016-0.582.3e-03Click!
PRRX1chr1_+_170633312-0.554.1e-03Click!


Activity profile for motif PRRX1,2.p2.

activity profile for motif PRRX1,2.p2


Sorted Z-values histogram for motif PRRX1,2.p2

Sorted Z-values for motif PRRX1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of PRRX1,2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr1_+_84630575 7.876 NM_001242860
NM_001242861
PRKACB

protein kinase, cAMP-dependent, catalytic, beta

chr9_-_14086901 6.849 NFIB
nuclear factor I/B
chr5_-_88119604 5.740 NM_001193348
NM_001193349
MEF2C

myocyte enhancer factor 2C

chr15_+_25281105 4.114 SNRPN
small nuclear ribonucleoprotein polypeptide N
chr1_+_84647342 4.034 NM_001242862
PRKACB
protein kinase, cAMP-dependent, catalytic, beta
chr1_+_84630014 3.889 NM_001242857
NM_001242858
NM_001242859
PRKACB


protein kinase, cAMP-dependent, catalytic, beta


chr4_+_41614725 3.578 LIMCH1
LIM and calponin homology domains 1
chr9_-_14398981 3.106 NM_001190738
NFIB
nuclear factor I/B
chr11_+_87032428 3.034 TMEM135
transmembrane protein 135
chr3_-_18480203 2.951 NM_001131010
SATB1
SATB homeobox 1
chr8_-_17555158 2.942 NM_020749
MTUS1
microtubule associated tumor suppressor 1
chr5_-_88199868 2.757 NM_001131005
NM_001193347
MEF2C

myocyte enhancer factor 2C

chr5_-_88179278 2.649 NM_001193350
NM_002397
MEF2C

myocyte enhancer factor 2C

chr1_+_84630374 2.647 PRKACB
protein kinase, cAMP-dependent, catalytic, beta
chr13_+_36050885 2.616 NM_001204197
NBEA
neurobeachin
chr4_+_41540187 2.522 LIMCH1
LIM and calponin homology domains 1
chr17_-_67138013 2.518 NM_080284
ABCA6
ATP-binding cassette, sub-family A (ABC1), member 6
chr2_-_188312872 2.479 NM_005795
CALCRL
calcitonin receptor-like
chr18_-_53089722 2.470 NM_001243233
TCF4
transcription factor 4
chr7_+_115863004 2.409 NM_152829
TES
testis derived transcript (3 LIM domains)
chr6_-_130031278 2.368 NM_033515
ARHGAP18
Rho GTPase activating protein 18
chr4_+_41540320 2.355 LIMCH1
LIM and calponin homology domains 1
chr13_-_72441312 2.348 NM_004392
NM_080759
NM_080760
DACH1


dachshund homolog 1 (Drosophila)


chr10_-_116392099 2.283 ABLIM1
actin binding LIM protein 1
chr4_+_41614933 2.282 LIMCH1
LIM and calponin homology domains 1
chr4_-_16900348 2.277 NM_001130834
NM_001290
LDB2

LIM domain binding 2

chr4_-_16900256 2.253 LDB2
LIM domain binding 2
chr4_-_16900028 2.249 LDB2
LIM domain binding 2
chr4_+_41614911 2.233 NM_001112719
NM_001112720
LIMCH1

LIM and calponin homology domains 1

chr4_+_140587086 2.164 MGST2
microsomal glutathione S-transferase 2
chr4_+_41700736 2.131 LIMCH1
LIM and calponin homology domains 1
chr10_+_94594469 2.057 NM_001013848
EXOC6
exocyst complex component 6
chr1_+_61547625 2.056 NM_001134673
NM_005595
NFIA

nuclear factor I/A

chr9_-_13250313 2.051 NM_003829
MPDZ
multiple PDZ domain protein
chr1_+_61547388 2.024 NM_001145512
NFIA
nuclear factor I/A
chr1_+_84768333 1.999 NM_001134664
SAMD13
sterile alpha motif domain containing 13
chr8_-_82395401 1.927 NM_001442
FABP4
fatty acid binding protein 4, adipocyte
chr17_+_48821106 1.895 LUC7L3
LUC7-like 3 (S. cerevisiae)
chr6_-_84419018 1.879 SNAP91
synaptosomal-associated protein, 91kDa homolog (mouse)
chr12_+_9142136 1.867 NM_005810
KLRG1
killer cell lectin-like receptor subfamily G, member 1
chr7_+_102553343 1.859 NM_001031692
NM_005824
LRRC17

leucine rich repeat containing 17

chr10_-_116418056 1.824 NM_002313
ABLIM1
actin binding LIM protein 1
chr8_-_17579729 1.813 NM_001001931
MTUS1
microtubule associated tumor suppressor 1
chr6_-_76203256 1.780 NM_015687
FILIP1
filamin A interacting protein 1
chr1_+_61869699 1.778 NFIA
nuclear factor I/A
chr6_-_84419108 1.760 NM_001242793
NM_001242794
NM_014841
SNAP91


synaptosomal-associated protein, 91kDa homolog (mouse)


chr9_+_6215785 1.725 NM_001199640
NM_001199641
NM_033439
IL33


interleukin 33


chr5_-_111312522 1.718 NM_001142474
NM_001142475
C5orf13

chromosome 5 open reading frame 13

chr2_+_109204777 1.704 LIMS1
LIM and senescent cell antigen-like domains 1
chr12_+_93963597 1.661 NM_003877
SOCS2
suppressor of cytokine signaling 2
chr10_+_35426709 1.658 NM_183011
NM_183012
CREM

cAMP responsive element modulator

chr14_-_92413738 1.644 FBLN5
fibulin 5
chr4_-_186733372 1.642 NM_003603
NM_001145670
SORBS2

sorbin and SH3 domain containing 2

chr9_+_79115548 1.640 NM_001097636
GCNT1
glucosaminyl (N-acetyl) transferase 1, core 2
chr2_-_191872322 1.617 STAT1
signal transducer and activator of transcription 1, 91kDa
chr11_-_33913835 1.610 NM_005574
LMO2
LIM domain only 2 (rhombotin-like 1)
chr6_+_144612872 1.593 NM_007124
UTRN
utrophin
chr12_+_20724797 1.588 NM_001244683
PDE3A
phosphodiesterase 3A, cGMP-inhibited
chr7_-_86595203 1.540 NM_152748
KIAA1324L
KIAA1324-like
chr3_+_132316080 1.538 NM_016557
CCRL1
chemokine (C-C motif) receptor-like 1
chr8_-_17580024 1.524 NM_001166393
MTUS1
microtubule associated tumor suppressor 1
chr17_+_61086897 1.514 NM_025185
TANC2
tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2
chr1_+_33004771 1.510 NM_001040441
ZBTB8A
zinc finger and BTB domain containing 8A
chr9_-_75568232 1.503 NM_000689
ALDH1A1
aldehyde dehydrogenase 1 family, member A1
chr2_-_99279935 1.485 NM_001160154
MGAT4A
mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A
chr15_+_57511616 1.472 NM_207040
TCF12
transcription factor 12
chr17_-_66951381 1.466 NM_007168
ABCA8
ATP-binding cassette, sub-family A (ABC1), member 8
chrX_+_135230736 1.431 NM_001159700
FHL1
four and a half LIM domains 1
chr14_-_54423448 1.422 NM_001202
NM_130850
BMP4

bone morphogenetic protein 4

chr2_-_44586854 1.383 NM_001042385
NM_001042386
PREPL

prolyl endopeptidase-like

chr19_+_30863318 1.317 NM_014717
ZNF536
zinc finger protein 536
chr1_+_212475147 1.288 NM_001199756
PPP2R5A
protein phosphatase 2, regulatory subunit B', alpha
chr8_-_93111915 1.278 NM_001198628
RUNX1T1
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
chr13_-_45010937 1.268 TSC22D1
TSC22 domain family, member 1
chr7_+_94297448 1.266 PEG10
paternally expressed 10
chr18_+_72922725 1.252 NM_005786
TSHZ1
teashirt zinc finger homeobox 1
chr14_+_101295409 1.250 MEG3
maternally expressed 3 (non-protein coding)
chr1_+_97260515 1.243


chrX_-_10535476 1.186 NM_001193278
NM_001193279
NM_001193280
NM_001193281
MID1



midline 1 (Opitz/BBB syndrome)



chr4_-_70626429 1.141 NM_014465
SULT1B1
sulfotransferase family, cytosolic, 1B, member 1
chr3_-_114478117 1.125 NM_001164344
NM_001164345
ZBTB20

zinc finger and BTB domain containing 20

chr3_+_20081523 1.119 NM_003884
KAT2B
K(lysine) acetyltransferase 2B
chr1_-_110933683 1.118 NM_001201546
NM_001201547
NM_001201548
NM_001201549
NM_004696
SLC16A4




solute carrier family 16, member 4 (monocarboxylic acid transporter 5)




chr5_+_140602914 1.114 NM_018934
PCDHB14
protocadherin beta 14
chr2_+_189839132 1.112 COL3A1
collagen, type III, alpha 1
chr18_-_22931970 1.109 ZNF521
zinc finger protein 521
chr18_+_6834431 1.108 NM_001010000
ARHGAP28
Rho GTPase activating protein 28
chr1_+_196621007 1.103 NM_000186
NM_001014975
CFH

complement factor H

chr12_+_32654976 1.096 NM_139241
FGD4
FYVE, RhoGEF and PH domain containing 4
chr9_-_75567915 1.093 ALDH1A1
aldehyde dehydrogenase 1 family, member A1
chr6_-_13408368 1.090 NM_001242630
GFOD1
glucose-fructose oxidoreductase domain containing 1
chr2_+_109237679 1.071 NM_001193484
LIMS1
LIM and senescent cell antigen-like domains 1
chr2_-_234474197 1.071 NM_018218
USP40
ubiquitin specific peptidase 40
chr5_+_61874561 1.069 NM_181506
LRRC70
leucine rich repeat containing 70
chr2_+_132480063 1.055 NM_013310
C2orf27A
chromosome 2 open reading frame 27A
chr9_+_97521930 1.053 NM_001193329
C9orf3
chromosome 9 open reading frame 3
chr3_+_113616317 1.050 NM_001172105
GRAMD1C
GRAM domain containing 1C
chr18_-_22932109 1.050 NM_015461
ZNF521
zinc finger protein 521
chr12_+_28410132 1.025 NM_018318
CCDC91
coiled-coil domain containing 91
chrX_+_7137471 1.014 NM_000351
STS
steroid sulfatase (microsomal), isozyme S
chr10_+_63808968 1.011 NM_001244638
ARID5B
AT rich interactive domain 5B (MRF1-like)
chr14_+_70236266 1.007 SRSF5
serine/arginine-rich splicing factor 5
chr2_-_48115846 0.998 NM_025133
FBXO11
F-box protein 11
chr3_-_141747434 0.982 NM_001178141
NM_001178142
NM_006286
TFDP2


transcription factor Dp-2 (E2F dimerization partner 2)


chr9_+_2015218 0.979 NM_003070
NM_139045
SMARCA2

SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2

chr1_+_33004969 0.976 ZBTB8A
zinc finger and BTB domain containing 8A
chr10_+_102123420 0.968


chr2_+_169937616 0.951 NM_001142271
DHRS9
dehydrogenase/reductase (SDR family) member 9
chr9_-_14314036 0.947 NM_001190737
NM_005596
NFIB

nuclear factor I/B

chr5_-_39394423 0.946 DAB2
disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)
chr13_-_41556188 0.939 ELF1
E74-like factor 1 (ets domain transcription factor)
chr12_+_29376596 0.922 NM_018099
FAR2
fatty acyl CoA reductase 2
chr15_+_93443559 0.906 CHD2
chromodomain helicase DNA binding protein 2
chrX_+_28605558 0.906 NM_014271
IL1RAPL1
interleukin 1 receptor accessory protein-like 1
chr17_-_67057046 0.905 NM_080283
ABCA9
ATP-binding cassette, sub-family A (ABC1), member 9
chr17_-_46622274 0.904 NM_002145
HOXB2
homeobox B2
chr3_+_46448678 0.885 NM_003965
NM_001130910
CCRL2

chemokine (C-C motif) receptor-like 2

chrX_+_13671224 0.880 NM_152634
TCEANC
transcription elongation factor A (SII) N-terminal and central domain containing
chr3_+_136649316 0.877 NM_001190796
NCK1
NCK adaptor protein 1
chr11_+_92085261 0.874 NM_001008781
FAT3
FAT tumor suppressor homolog 3 (Drosophila)
chrX_-_135749436 0.872 ARHGEF6
Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
chr1_-_110933635 0.868 SLC16A4
solute carrier family 16, member 4 (monocarboxylic acid transporter 5)
chr9_+_71944240 0.867 NM_004816
FAM189A2
family with sequence similarity 189, member A2
chr21_-_39870303 0.859 NM_001136155
NM_182918
ERG

v-ets erythroblastosis virus E26 oncogene homolog (avian)

chr1_+_100316530 0.857 NM_000646
AGL
amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase
chr5_-_168271852 0.854


chr7_+_77469446 0.852 NM_001127357
NM_001127359
NM_020432
PHTF2


putative homeodomain transcription factor 2


chr12_+_15699277 0.852 NM_030668
NM_030669
NM_030670
NM_030671
PTPRO



protein tyrosine phosphatase, receptor type, O



chrX_-_117107700 0.833 NM_033495
NM_001168300
KLHL13

kelch-like 13 (Drosophila)

chr2_-_165424993 0.831 GRB14
growth factor receptor-bound protein 14
chr9_+_82187469 0.831 TLE4
transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)
chr12_-_29937691 0.830 NM_175861
TMTC1
transmembrane and tetratricopeptide repeat containing 1
chr20_-_45976626 0.829 ZMYND8
zinc finger, MYND-type containing 8
chr4_-_138453564 0.824 PCDH18
protocadherin 18
chr16_+_53133063 0.819 CHD9
chromodomain helicase DNA binding protein 9
chr7_-_108142934 0.817 PNPLA8
patatin-like phospholipase domain containing 8
chr2_+_128928040 0.817 UGGT1
UDP-glucose glycoprotein glucosyltransferase 1
chr2_+_109204904 0.812 NM_001193488
LIMS1
LIM and senescent cell antigen-like domains 1
chr5_-_94417185 0.812 MCTP1
multiple C2 domains, transmembrane 1
chr2_+_179184970 0.811 NM_145739
OSBPL6
oxysterol binding protein-like 6
chr2_-_183387063 0.803 NM_005019
NM_001003683
PDE1A

phosphodiesterase 1A, calmodulin-dependent

chr4_-_159094163 0.794 NM_001031700
NM_001128424
FAM198B

family with sequence similarity 198, member B

chr20_+_42574535 0.790 NM_001098798
TOX2
TOX high mobility group box family member 2
chr7_-_27183225 0.790 NM_019102
HOXA5
homeobox A5
chr12_-_50616425 0.788 NM_001113547
LIMA1
LIM domain and actin binding 1
chr4_-_152147520 0.786 NM_001009555
NM_001128923
SH3D19

SH3 domain containing 19

chr5_+_175108463 0.778 NM_022304
HRH2
histamine receptor H2
chr3_-_64211111 0.770 NM_198859
PRICKLE2
prickle homolog 2 (Drosophila)
chrX_-_18690187 0.768 NM_000330
RS1
retinoschisin 1
chr2_+_210444364 0.767 NM_002374
NM_031845
NM_031847
MAP2


microtubule-associated protein 2


chr12_-_7848324 0.766 NM_020634
GDF3
growth differentiation factor 3
chr12_-_10021932 0.764 CLEC2B
C-type lectin domain family 2, member B
chr2_+_189839078 0.764 NM_000090
COL3A1
collagen, type III, alpha 1
chr10_+_35464514 0.761 NM_182769
NM_182770
CREM

cAMP responsive element modulator

chr2_+_173686314 0.759 NM_001100397
RAPGEF4
Rap guanine nucleotide exchange factor (GEF) 4
chr1_+_145524989 0.756 NM_003637
ITGA10
integrin, alpha 10
chr4_-_186578122 0.754 NM_001145674
NM_001145675
SORBS2

sorbin and SH3 domain containing 2

chr2_-_188419049 0.750 TFPI
tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
chr9_+_12774988 0.749 NM_203403
C9orf150
chromosome 9 open reading frame 150
chr20_+_33759773 0.748 NM_006404
PROCR
protein C receptor, endothelial
chr5_+_65372744 0.748 ERBB2IP
erbb2 interacting protein
chr3_-_112358510 0.746 CCDC80
coiled-coil domain containing 80
chr10_-_74283693 0.744 NM_001195519
MICU1
mitochondrial calcium uptake 1
chr7_+_129015483 0.743 NM_001130722
AHCYL2
adenosylhomocysteinase-like 2
chr6_-_133119625 0.739 NM_052831
C6orf192
chromosome 6 open reading frame 192
chr12_+_101988746 0.737 NM_002465
NM_206819
NM_206820
NM_206821
MYBPC1



myosin binding protein C, slow type



chr18_+_33234532 0.737 NM_020474
GALNT1
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 1 (GalNAc-T1)
chr4_-_152149042 0.737 NM_001243349
SH3D19
SH3 domain containing 19
chr6_+_153019029 0.735 NM_025107
MYCT1
myc target 1
chr3_-_112358758 0.734 CCDC80
coiled-coil domain containing 80
chr3_-_69037498 0.732 C3orf64
chromosome 3 open reading frame 64
chr18_-_21891469 0.728 NM_001242508
OSBPL1A
oxysterol binding protein-like 1A
chr5_+_115898218 0.725


chr6_+_155538096 0.723 NM_001010927
TIAM2
T-cell lymphoma invasion and metastasis 2
chr3_+_25470067 0.719 RARB
retinoic acid receptor, beta
chr3_+_159557745 0.718 SCHIP1
schwannomin interacting protein 1
chr6_-_75970566 0.717 TMEM30A
transmembrane protein 30A
chr6_+_136172802 0.714 NM_018945
PDE7B
phosphodiesterase 7B
chr5_+_68710938 0.712 NM_001038603
NM_001244734
MARVELD2

MARVEL domain containing 2

chr8_-_93075190 0.708 NM_004349
RUNX1T1
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
chr12_+_74931550 0.708 NM_001136262
ATXN7L3B
ataxin 7-like 3B
chr5_+_95066628 0.707 NM_014899
RHOBTB3
Rho-related BTB domain containing 3
chr21_-_40033617 0.707 NM_001243432
NM_001136154
NM_004449
ERG


v-ets erythroblastosis virus E26 oncogene homolog (avian)


chr20_+_42544781 0.704 NM_001098796
NM_032883
TOX2

TOX high mobility group box family member 2

chr11_-_31531109 0.704 NM_144981
IMMP1L
IMP1 inner mitochondrial membrane peptidase-like (S. cerevisiae)
chr2_+_177016112 0.700 NM_014621
HOXD4
homeobox D4
chr17_+_39382878 0.692 NM_031961
KRTAP9-2
keratin associated protein 9-2
chr6_-_32157511 0.691 NM_002586
PBX2
pre-B-cell leukemia homeobox 2
chr17_-_46688279 0.691 HOXB7
homeobox B7
chr3_-_15839674 0.688 NM_001195098
ANKRD28
ankyrin repeat domain 28
chr5_+_140624916 0.688 PCDHB15
protocadherin beta 15
chr11_+_60552820 0.678 NM_206893
MS4A10
membrane-spanning 4-domains, subfamily A, member 10
chr12_-_10022457 0.677 NM_005127
CLEC2B
C-type lectin domain family 2, member B
chr3_+_141043054 0.676 NM_001080412
ZBTB38
zinc finger and BTB domain containing 38
chr4_-_70725792 0.676 NM_005420
SULT1E1
sulfotransferase family 1E, estrogen-preferring, member 1
chr8_-_17752847 0.675 NM_147203
NM_201553
NM_004467
NM_201552
FGL1



fibrinogen-like 1



chr5_-_111091947 0.675 NM_001142483
C5orf13
chromosome 5 open reading frame 13
chr10_-_65028825 0.674 NM_004241
JMJD1C
jumonji domain containing 1C
chr11_-_102745666 0.672 NM_002426
MMP12
matrix metallopeptidase 12 (macrophage elastase)
chr9_-_77643307 0.668 NM_152420
C9orf41
chromosome 9 open reading frame 41

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.07 8.89e-05 GO:0009987 cellular process
1.14 2.23e-02 GO:0044260 cellular macromolecule metabolic process

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.10 3.13e-05 GO:0005737 cytoplasm
1.06 2.78e-04 GO:0044424 intracellular part
1.06 3.18e-04 GO:0005622 intracellular
1.07 6.01e-04 GO:0043226 organelle
1.07 7.97e-04 GO:0043229 intracellular organelle
1.08 1.83e-03 GO:0043231 intracellular membrane-bounded organelle
1.08 2.02e-03 GO:0043227 membrane-bounded organelle
1.11 6.55e-03 GO:0044422 organelle part
1.30 8.17e-03 GO:0005783 endoplasmic reticulum
1.11 1.01e-02 GO:0044446 intracellular organelle part
1.10 2.05e-02 GO:0005634 nucleus
1.10 3.17e-02 GO:0044444 cytoplasmic part

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.10 1.28e-03 GO:0005515 protein binding
1.41 4.28e-03 GO:0005509 calcium ion binding