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• Activity deltas table
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Motif ID: REST.p3

Z-value: 0.756

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Top targets:

Promoter	Score	Refseq	Gene Symbol	Gene Name
chr17_+_72667255	1.275	NM_175738	RAB37	RAB37, member RAS oncogene family
chr4_+_8582216	1.045	NM_080819	GPR78	G protein-coupled receptor 78
chr5_+_71014989	0.923	NM_004291	CARTPT	CART prepropeptide
chrX_-_153141284	0.790		L1CAM	L1 cell adhesion molecule
chr5_-_151304322	0.766	NM_000171 NM_001146040	GLRA1	glycine receptor, alpha 1
chr17_-_27240982	0.757		PHF12	PHD finger protein 12
chr3_+_193853930	0.722	NM_005524	HES1	hairy and enhancer of split 1, (Drosophila)
chr10_+_99609994	0.684	NM_001010917	GOLGA7B	golgin A7 family, member B
chr8_-_145559831	0.677	NM_031309	SCRT1	scratch homolog 1, zinc finger protein (Drosophila)
chr5_+_33936490	0.653	NM_016568	RXFP3	relaxin/insulin-like family peptide receptor 3
chr11_+_22359666	0.642	NM_020346	SLC17A6	solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 6
chr2_-_27531113	0.637	NM_003353	UCN	urocortin
chr12_+_175872	0.625	NM_001170738	IQSEC3	IQ motif and Sec7 domain 3
chr3_+_193853937	0.625		HES1	hairy and enhancer of split 1, (Drosophila)
chr11_-_27742224	0.616	NM_001143805 NM_001143806 NM_170732	BDNF	brain-derived neurotrophic factor
chr1_-_151689246	0.538	NM_007185	CELF3	CUGBP, Elav-like family member 3
chr8_-_57358511	0.500	NM_006211	PENK	proenkephalin
chr6_+_154360442	0.485	NM_000914 NM_001008503 NM_001008504 NM_001008505 NM_001145282 NM_001145283 NM_001145284 NM_001145285 NM_001145286	OPRM1	opioid receptor, mu 1
chr15_-_32162778	0.484		OTUD7A	OTU domain containing 7A
chr5_+_175298604	0.462		CPLX2	complexin 2
chr6_+_25652373	0.459	NM_006998	SCGN	secretagogin, EF-hand calcium binding protein
chr2_-_51259239	0.441		NRXN1	neurexin 1
chrX_-_47479229	0.418	NM_006950 NM_133499	SYN1	synapsin I
chr5_+_175298492	0.397	NM_001008220	CPLX2	complexin 2
chr11_-_125773086	0.364	NM_031307	PUS3	pseudouridylate synthase 3
chr3_+_9745509	0.362	NM_153635	CPNE9	copine family member IX
chrX_-_47479095	0.349
chr16_+_24267474	0.348		CACNG3	calcium channel, voltage-dependent, gamma subunit 3
chr11_-_75141015	0.347		KLHL35	kelch-like 35 (Drosophila)
chr1_-_102462789	0.341	NM_058170	OLFM3	olfactomedin 3
chr3_+_62305395	0.308	NM_020685	C3orf14	chromosome 3 open reading frame 14
chr15_-_83378488	0.304	NM_004644	AP3B2	adaptor-related protein complex 3, beta 2 subunit
chr8_+_57358361	0.303
chr16_+_24267672	0.297		CACNG3	calcium channel, voltage-dependent, gamma subunit 3
chr20_-_60795270	0.292	NM_007232	HRH3	histamine receptor H3
chr7_+_8474016	0.286		NXPH1	neurexophilin 1
chr12_+_52695648	0.282	NM_002284	KRT86	keratin 86
chr7_+_8473584	0.281	NM_152745	NXPH1	neurexophilin 1
chrX_-_153141398	0.281	NM_000425 NM_001143963 NM_024003	L1CAM	L1 cell adhesion molecule
chr5_-_176037091	0.275	NM_052899	GPRIN1	G protein regulated inducer of neurite outgrowth 1
chr12_+_113796374	0.271		PLBD2	phospholipase B domain containing 2
chr6_+_35773070	0.269	NM_182548	LHFPL5	lipoma HMGIC fusion partner-like 5
chr7_+_8473237	0.265		NXPH1	neurexophilin 1
chr11_-_75141210	0.259		KLHL35	kelch-like 35 (Drosophila)
chr19_-_40724272	0.254	NM_152479	TTC9B	tetratricopeptide repeat domain 9B
chr11_-_27721179	0.251	NM_170734	BDNF	brain-derived neurotrophic factor
chr15_-_72612127	0.225		CELF6	CUGBP, Elav-like family member 6
chr3_-_187388105	0.220	NM_001048	SST	somatostatin
chr11_-_75141517	0.219	NM_001039548	KLHL35	kelch-like 35 (Drosophila)
chr1_-_102462371	0.216		OLFM3	olfactomedin 3
chr10_-_102790850	0.216		PDZD7	PDZ domain containing 7
chr8_-_91094924	0.214	NM_004929	CALB1	calbindin 1, 28kDa
chr10_+_60937226	0.213	NM_001143774	PHYHIPL	phytanoyl-CoA 2-hydroxylase interacting protein-like
chr18_-_5197240	0.211	NM_001145194	C18orf42	chromosome 18 open reading frame 42
chr2_-_51259536	0.205	NM_001135659 NM_004801	NRXN1	neurexin 1
chr10_-_102790877	0.197	NM_001195263 NM_024895	PDZD7	PDZ domain containing 7
chr5_+_175298538	0.195		CPLX2	complexin 2
chr14_-_74892804	0.190	NM_001105579	SYNDIG1L	synapse differentiation inducing 1-like
chr10_+_26505593	0.190		GAD2	glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)
chr19_-_55691468	0.185	NM_003180	SYT5	synaptotagmin V
chr3_+_120627026	0.185	NM_014980	STXBP5L	syntaxin binding protein 5-like
chr20_+_44657812	0.181	NM_020708	SLC12A5	solute carrier family 12 (potassium/chloride transporter), member 5
chr1_+_210111575	0.179		SYT14	synaptotagmin XIV
chr12_+_113229548	0.175	NM_001143854 NM_014954	RPH3A	rabphilin 3A homolog (mouse)
chr4_+_158141735	0.173	NM_000826 NM_001083619 NM_001083620	GRIA2	glutamate receptor, ionotropic, AMPA 2
chr3_-_131753757	0.168	NM_130808	CPNE4	copine IV
chr1_+_210111537	0.165	NM_001146261 NM_001146262 NM_001146264 NM_153262	SYT14	synaptotagmin XIV
chr3_-_48700317	0.165	NM_001407	CELSR3	cadherin, EGF LAG seven-pass G-type receptor 3 (flamingo homolog, Drosophila)
chr15_-_72612497	0.163	NM_052840	CELF6	CUGBP, Elav-like family member 6
chr3_+_62304667	0.163		C3orf14	chromosome 3 open reading frame 14
chr10_+_26505235	0.149	NM_000818 NM_001134366	GAD2	glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)
chr10_+_28821724	0.142
chr9_+_140033588	0.142	NM_000832 NM_001185090 NM_001185091 NM_007327 NM_021569	GRIN1	glutamate receptor, ionotropic, N-methyl D-aspartate 1
chr15_-_72612247	0.141	NM_001172684	CELF6	CUGBP, Elav-like family member 6
chr14_-_58332591	0.137	NM_001206920	SLC35F4	solute carrier family 35, member F4
chr1_-_20834609	0.136	NM_024544	MUL1	mitochondrial E3 ubiquitin protein ligase 1
chr4_-_175750377	0.135	NM_001042543 NM_006529	GLRA3	glycine receptor, alpha 3
chr12_+_119419299	0.134	NM_194286	SRRM4	serine/arginine repetitive matrix 4
chr2_-_42720476	0.127		KCNG3	potassium voltage-gated channel, subfamily G, member 3
chr12_+_113796370	0.126	NM_001159727 NM_173542	PLBD2	phospholipase B domain containing 2
chr1_-_175712669	0.124	NM_003285	TNR	tenascin R (restrictin, janusin)
chr15_-_27018917	0.122	NM_021912	GABRB3	gamma-aminobutyric acid (GABA) A receptor, beta 3
chr5_-_135701163	0.122	NM_001167576 NM_001167577 NM_020389	TRPC7	transient receptor potential cation channel, subfamily C, member 7
chr14_-_94759594	0.121	NM_001100607	SERPINA10	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10
chr10_+_28822387	0.119	NM_016628 NM_100486	WAC	WW domain containing adaptor with coiled-coil
chr17_+_42385780	0.118	NM_001144825 NM_001144826 NM_006695	RUNDC3A	RUN domain containing 3A
chr1_+_212606194	0.116	NM_013349	NENF	neudesin neurotrophic factor
chr6_+_43149925	0.109		CUL9	cullin 9
chr15_+_75287829	0.106	NM_001178111 NM_001178112 NM_138967	SCAMP5	secretory carrier membrane protein 5
chr16_+_2510080	0.104	NM_025108	C16orf59	chromosome 16 open reading frame 59
chr1_+_154540250	0.100	NM_000748	CHRNB2	cholinergic receptor, nicotinic, beta 2 (neuronal)
chr1_-_209825797	0.098	NM_000228	LAMB3	laminin, beta 3
chr9_-_139096954	0.098	NM_178138	LHX3	LIM homeobox 3
chr1_-_20834516	0.093		MUL1	mitochondrial E3 ubiquitin protein ligase 1
chr15_+_94774763	0.092		MCTP2	multiple C2 domains, transmembrane 2
chr1_+_171750829	0.090		METTL13	methyltransferase like 13
chr19_+_15197790	0.088	NM_001004713	OR1I1	olfactory receptor, family 1, subfamily I, member 1
chr15_+_69222838	0.085	NM_145658 NM_001184780	SPESP1 NOX5	sperm equatorial segment protein 1 NADPH oxidase, EF-hand calcium binding domain 5
chr6_+_110300197	0.081	NM_005284	GPR6	G protein-coupled receptor 6
chr20_-_62284701	0.081	NM_015894	STMN3	stathmin-like 3
chr6_+_153071931	0.078	NM_003381 NM_194435	VIP	vasoactive intestinal peptide
chr10_-_44880452	0.077	NM_000609 NM_001033886 NM_001178134 NM_199168	CXCL12	chemokine (C-X-C motif) ligand 12
chr14_-_51561657	0.072		TRIM9	tripartite motif containing 9
chr6_+_44238479	0.070	NM_001137560	TMEM151B	transmembrane protein 151B
chr19_+_34175433	0.065	NM_022467	CHST8	carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 8
chr1_-_153123426	0.064	NM_001014291	SPRR2G	small proline-rich protein 2G
chr1_+_171750807	0.058		METTL13	methyltransferase like 13
chr1_-_241520467	0.056	NM_002924	RGS7	regulator of G-protein signaling 7
chr12_-_99288502	0.054	NM_001204065 NM_001204079 NM_001204080 NM_001204081	ANKS1B	ankyrin repeat and sterile alpha motif domain containing 1B
chr9_-_104357202	0.053	NM_147180	PPP3R2	protein phosphatase 3, regulatory subunit B, beta
chr9_+_131038500	0.052		SWI5	SWI5 recombination repair homolog (yeast)
chr17_+_80332152	0.051	NM_018949	UTS2R	urotensin 2 receptor
chr6_-_71666740	0.051	NM_080742	B3GAT2	beta-1,3-glucuronyltransferase 2 (glucuronosyltransferase S)
chr1_+_171750760	0.050	NM_001007239 NM_014955 NM_015935	METTL13	methyltransferase like 13
chr16_+_69345250	0.049	NM_013245	VPS4A	vacuolar protein sorting 4 homolog A (S. cerevisiae)
chr7_+_145813452	0.048	NM_014141	CNTNAP2	contactin associated protein-like 2
chr20_+_44657858	0.047		SLC12A5	solute carrier family 12 (potassium/chloride transporter), member 5
chr11_-_123524881	0.045		SCN3B	sodium channel, voltage-gated, type III, beta
chr19_-_45737466	0.044	NM_138568	EXOC3L2	exocyst complex component 3-like 2
chr8_+_68864341	0.040		PREX2	phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2
chrX_+_153237990	0.037	NM_003492	TMEM187	transmembrane protein 187
chr17_-_27332888	0.036	NM_001098635 NM_178860	SEZ6	seizure related 6 homolog (mouse)
chr6_+_43149905	0.035	NM_015089	CUL9	cullin 9
chr14_+_93389444	0.030	NM_001275	CHGA	chromogranin A (parathyroid secretory protein 1)
chr22_+_31795581	0.030		DRG1	developmentally regulated GTP binding protein 1
chr11_+_45907198	0.029		MAPK8IP1	mitogen-activated protein kinase 8 interacting protein 1
chr20_+_5891973	0.028	NM_001819	CHGB	chromogranin B (secretogranin 1)
chr6_+_138725314	0.027	NM_014320	HEBP2	heme binding protein 2
chr7_-_131241321	0.025	NM_001018111 NM_005397	PODXL	podocalyxin-like
chr22_+_31795538	0.020	NM_004147	DRG1	developmentally regulated GTP binding protein 1
chr12_+_71833518	0.018		LGR5	leucine-rich repeat containing G protein-coupled receptor 5
chr9_+_131038421	0.017	NM_001040011	SWI5	SWI5 recombination repair homolog (yeast)
chr1_-_241520384	0.016		RGS7	regulator of G-protein signaling 7
chr12_+_6561176	0.015	NM_018009	TAPBPL	TAP binding protein-like
chr11_-_128807712	0.013	NM_001195194	TP53AIP1	tumor protein p53 regulated apoptosis inducing protein 1
chr6_+_138725458	0.008		HEBP2	heme binding protein 2
chr17_-_79881304	0.007	NM_032711	MAFG	v-maf musculoaponeurotic fibrosarcoma oncogene homolog G (avian)
chr22_-_18256748	0.006	NM_001244572 NM_197966	BID	BH3 interacting domain death agonist
chr3_-_113897849	0.006	NM_000796 NM_033663	DRD3	dopamine receptor D3
chr19_-_45927175	0.003	NM_001166049 NM_001983	ERCC1	excision repair cross-complementing rodent repair deficiency, complementation group 1 (includes overlapping antisense sequence)
chr11_+_32112607	0.002		RCN1	reticulocalbin 1, EF-hand calcium binding domain
chr8_-_93977715	0.000	NM_001191036	C8orf83	chromosome 8 open reading frame 83

Gene overrepresentation in process category:

enrichment	p-value	GO term	description
7.17	6.88e-09	GO:0019226	transmission of nerve impulse
7.17	6.88e-09	GO:0035637	multicellular organismal signaling
7.63	9.20e-09	GO:0007268	synaptic transmission
5.76	2.60e-06	GO:0007186	G-protein coupled receptor protein signaling pathway
7.63	7.46e-06	GO:0007610	behavior
3.42	1.89e-05	GO:0050877	neurological system process
3.06	2.42e-05	GO:0003008	system process
4.44	4.86e-05	GO:0007267	cell-cell signaling
5.38	4.32e-04	GO:0055082	cellular chemical homeostasis
3.54	6.79e-04	GO:0007154	cell communication
5.14	1.88e-03	GO:0006873	cellular ion homeostasis
5.04	2.31e-03	GO:0046903	secretion
4.45	3.45e-03	GO:0019725	cellular homeostasis
4.74	4.26e-03	GO:0050801	ion homeostasis
25.99	8.09e-03	GO:0050433	regulation of catecholamine secretion
8.64	8.67e-03	GO:0031644	regulation of neurological system process
25.03	9.45e-03	GO:0045776	negative regulation of blood pressure
1.92	9.63e-03	GO:0023052	signaling
3.94	1.28e-02	GO:0048878	chemical homeostasis
9.75	1.81e-02	GO:0008217	regulation of blood pressure
9.48	2.12e-02	GO:0007611	learning or memory
12.61	2.45e-02	GO:0030534	adult behavior
18.27	3.40e-02	GO:0051952	regulation of amine transport
8.67	3.50e-02	GO:0050890	cognition
4.98	4.29e-02	GO:0055080	cation homeostasis
33.78	4.51e-02	GO:0042749	regulation of circadian sleep/wake cycle
33.78	4.51e-02	GO:0045187	regulation of circadian sleep/wake cycle, sleep
8.18	4.84e-02	GO:0051969	regulation of transmission of nerve impulse

Gene overrepresentation in compartment category:

enrichment	p-value	GO term	description
8.22	1.79e-07	GO:0044456	synapse part
6.54	1.01e-06	GO:0045202	synapse
15.54	5.42e-06	GO:0008021	synaptic vesicle
4.45	1.09e-05	GO:0016023	cytoplasmic membrane-bounded vesicle
4.37	1.45e-05	GO:0031988	membrane-bounded vesicle
4.19	2.71e-05	GO:0031410	cytoplasmic vesicle
22.53	3.02e-05	GO:0030672	synaptic vesicle membrane
4.06	4.37e-05	GO:0031982	vesicle
9.45	5.64e-05	GO:0030136	clathrin-coated vesicle
13.92	8.40e-05	GO:0030665	clathrin coated vesicle membrane
4.48	1.38e-04	GO:0030054	cell junction
7.72	3.04e-04	GO:0030135	coated vesicle
5.30	3.22e-04	GO:0043005	neuron projection
6.56	3.60e-04	GO:0030659	cytoplasmic vesicle membrane
6.33	4.88e-04	GO:0012506	vesicle membrane
10.29	6.46e-04	GO:0030662	coated vesicle membrane
5.44	1.86e-03	GO:0044433	cytoplasmic vesicle part
8.00	3.36e-03	GO:0045211	postsynaptic membrane
3.11	1.06e-02	GO:0042995	cell projection
6.30	1.53e-02	GO:0030425	dendrite
29.81	1.57e-02	GO:0032589	neuron projection membrane
84.45	2.53e-02	GO:0032590	dendrite membrane
2.08	3.13e-02	GO:0044459	plasma membrane part

Gene overrepresentation in function category:

enrichment	p-value	GO term	description
14.08	4.76e-04	GO:0005230	extracellular ligand-gated ion channel activity
17.97	9.39e-04	GO:0005231	excitatory extracellular ligand-gated ion channel activity
38.98	6.29e-03	GO:0016594	glycine binding
8.12	1.11e-02	GO:0015276	ligand-gated ion channel activity
8.12	1.11e-02	GO:0022834	ligand-gated channel activity
84.45	2.36e-02	GO:0016933	extracellular-glycine-gated ion channel activity
84.45	2.36e-02	GO:0016934	extracellular-glycine-gated chloride channel activity
24.13	2.83e-02	GO:0005184	neuropeptide hormone activity
8.54	3.44e-02	GO:0005179	hormone activity
67.56	3.92e-02	GO:0022824	transmitter-gated ion channel activity
67.56	3.92e-02	GO:0022835	transmitter-gated channel activity
4.50	4.70e-02	GO:0022836	gated channel activity
4.00	4.83e-02	GO:0005216	ion channel activity