Motif ID: RFX1..5_RFXANK_RFXAP.p2

Z-value: 1.465


Transcription factors associated with RFX1..5_RFXANK_RFXAP.p2:

Gene SymbolEntrez IDGene Name
RFX1 5989 regulatory factor X, 1 (influences HLA class II expression)
RFX2 5990 regulatory factor X, 2 (influences HLA class II expression)
RFX3 5991 regulatory factor X, 3 (influences HLA class II expression)
RFX4 5992 regulatory factor X, 4 (influences HLA class II expression)
RFX5 5993 regulatory factor X, 5 (influences HLA class II expression)
RFXANK 8625 regulatory factor X-associated ankyrin-containing protein
RFXAP 5994 regulatory factor X-associated protein

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.p-valuePlot
RFX1chr19_-_141170960.501.1e-02Click!
RFX2chr19_-_61104910.386.5e-02Click!
RFX4chr12_+_1069949140.359.0e-02Click!
RFX5chr1_-_151319717-0.281.7e-01Click!
RFX3chr9_-_3525973-0.232.7e-01Click!
RFXANKchr19_+_19303732,
chr19_+_19303007
-0.164.4e-01Click!
RFXAPchr13_+_373933060.106.2e-01Click!


Activity profile for motif RFX1..5_RFXANK_RFXAP.p2.

activity profile for motif RFX1..5_RFXANK_RFXAP.p2


Sorted Z-values histogram for motif RFX1..5_RFXANK_RFXAP.p2

Sorted Z-values for motif RFX1..5_RFXANK_RFXAP.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of RFX1..5_RFXANK_RFXAP.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr5_-_149669187 2.335 CAMK2A
calcium/calmodulin-dependent protein kinase II alpha
chr5_-_149669400 2.009 NM_015981
NM_171825
CAMK2A

calcium/calmodulin-dependent protein kinase II alpha

chr5_-_179780314 1.886 NM_005110
GFPT2
glutamine-fructose-6-phosphate transaminase 2
chr22_+_23487512 1.639 NM_004914
RAB36
RAB36, member RAS oncogene family
chr3_-_123339423 1.550 NM_053031
NM_053032
MYLK

myosin light chain kinase

chr19_-_10679328 1.503 CDKN2D
cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)
chr7_-_102715171 1.401 NM_001111038
FBXL13
F-box and leucine-rich repeat protein 13
chr1_-_36915969 1.359 NM_145047
NM_206837
OSCP1

organic solute carrier partner 1

chr13_-_44361032 1.299 NM_001242863
NM_017993
ENOX1

ecto-NOX disulfide-thiol exchanger 1

chr1_-_159869897 1.298 NM_012337
CCDC19
coiled-coil domain containing 19
chr14_-_24657986 1.266 IPO4
importin 4
chr8_+_13424351 1.245 NM_001007090
C8orf48
chromosome 8 open reading frame 48
chr3_+_154797435 1.228 NM_000902
MME
membrane metallo-endopeptidase
chr14_-_24658010 1.197 NM_024658
IPO4
importin 4
chr6_-_112408636 1.179 NM_016262
TUBE1
tubulin, epsilon 1
chr3_-_58563070 1.155 FAM107A
family with sequence similarity 107, member A
chr11_+_8060179 1.152 NM_003320
TUB
tubby homolog (mouse)
chr3_-_123339178 1.133 MYLK
myosin light chain kinase
chr16_+_57050985 1.103 NM_032206
NLRC5
NLR family, CARD domain containing 5
chr6_+_109762204 1.080 SMPD2
sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase)
chr19_-_633526 1.066 POLRMT
polymerase (RNA) mitochondrial (DNA directed)
chr16_+_57662301 1.040 NM_001145771
NM_001145772
NM_001145773
NM_201524
NM_201525
GPR56




G protein-coupled receptor 56




chr15_-_71184611 1.029 NM_020147
THAP10
THAP domain containing 10
chr20_+_61904158 1.013 NM_018209
NM_175609
ARFGAP1

ADP-ribosylation factor GTPase activating protein 1

chr21_-_44846927 1.003 NM_173354
SIK1
salt-inducible kinase 1
chr16_-_53737713 0.989 NM_001127897
NM_015272
RPGRIP1L

RPGRIP1-like

chr20_+_61904183 0.976 ARFGAP1
ADP-ribosylation factor GTPase activating protein 1
chr8_+_22462286 0.957 KIAA1967
KIAA1967
chr8_+_22462273 0.956 KIAA1967
KIAA1967
chr19_-_10679620 0.949 NM_001800
NM_079421
CDKN2D

cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)

chr1_+_15736422 0.927 EFHD2
EF-hand domain family, member D2
chr8_+_22462532 0.910 NM_021174
KIAA1967
KIAA1967
chr19_-_50370799 0.903 NM_007254
PNKP
polynucleotide kinase 3'-phosphatase
chr7_-_102715014 0.889 NM_145032
FBXL13
F-box and leucine-rich repeat protein 13
chr17_+_41132581 0.885 NM_173079
RUNDC1
RUN domain containing 1
chr1_-_59249687 0.875 NM_002228
JUN
jun proto-oncogene
chr6_+_109761887 0.860 NM_003080
SMPD2
sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase)
chr19_-_633563 0.847 NM_005035
POLRMT
polymerase (RNA) mitochondrial (DNA directed)
chr17_+_41132587 0.841 RUNDC1
RUN domain containing 1
chr15_-_82555076 0.829 NM_001040610
NM_024580
EFTUD1

elongation factor Tu GTP binding domain containing 1

chr22_+_31892512 0.822 SFI1
Sfi1 homolog, spindle assembly associated (yeast)
chr9_+_96846710 0.822 NM_001253829
NM_152422
PTPDC1

protein tyrosine phosphatase domain containing 1

chr15_-_82554990 0.808 EFTUD1
elongation factor Tu GTP binding domain containing 1
chr1_+_15736387 0.808 NM_024329
EFHD2
EF-hand domain family, member D2
chr11_+_131780537 0.798 NM_001144058
NM_001144059
NM_016522
NTM


neurotrimin


chr4_-_177116713 0.789 NM_144644
SPATA4
spermatogenesis associated 4
chr16_+_3550916 0.784 NM_015041
CLUAP1
clusterin associated protein 1
chr12_+_48577365 0.781 NM_001013635
C12orf68
chromosome 12 open reading frame 68
chr20_-_44540685 0.769 PLTP
phospholipid transfer protein
chr19_-_59084735 0.769 MZF1
myeloid zinc finger 1
chr19_-_59084630 0.768 MZF1
myeloid zinc finger 1
chr10_-_25304865 0.768 NM_145010
ENKUR
enkurin, TRPC channel interacting protein
chr2_-_10588451 0.764 NM_002539
ODC1
ornithine decarboxylase 1
chr6_+_88117689 0.750 NM_001031743
C6orf165
chromosome 6 open reading frame 165
chr7_-_140624280 0.748 NM_004333
BRAF
v-raf murine sarcoma viral oncogene homolog B1
chr10_+_25305507 0.743 NM_024838
THNSL1
threonine synthase-like 1 (S. cerevisiae)
chr8_-_30515665 0.741 NM_002095
GTF2E2
general transcription factor IIE, polypeptide 2, beta 34kDa
chr15_+_90728118 0.738 NM_020210
SEMA4B
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B
chr8_+_42010463 0.734 NM_001134296
NM_006803
AP3M2

adaptor-related protein complex 3, mu 2 subunit

chr15_+_98503907 0.728 NM_183376
ARRDC4
arrestin domain containing 4
chr17_+_42081913 0.725 NM_153006
NAGS
N-acetylglutamate synthase
chr10_+_12391471 0.718 NM_020397
NM_153498
CAMK1D

calcium/calmodulin-dependent protein kinase ID

chr1_+_37940180 0.714 ZC3H12A
zinc finger CCCH-type containing 12A
chr6_+_109762043 0.707 SMPD2
sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase)
chr13_+_98605928 0.698 NM_002271
IPO5
importin 5
chr22_-_50746000 0.691 NM_012401
PLXNB2
plexin B2
chr3_+_126423037 0.689 NM_032343
CHCHD6
coiled-coil-helix-coiled-coil-helix domain containing 6
chr11_-_64885124 0.687 NM_014205
ZNHIT2
zinc finger, HIT-type containing 2
chr1_+_155178489 0.682 NM_002455
NM_198883
MTX1

metaxin 1

chr2_-_10588273 0.681 ODC1
ornithine decarboxylase 1
chr17_-_6543982 0.680 KIAA0753
KIAA0753
chr17_-_6544246 0.676 NM_014804
KIAA0753
KIAA0753
chr10_-_74856656 0.673 NM_000917
NM_001017962
NM_001142595
NM_001142596
P4HA1



prolyl 4-hydroxylase, alpha polypeptide I



chr22_+_31892372 0.669 SFI1
Sfi1 homolog, spindle assembly associated (yeast)
chr19_+_2785464 0.667 NM_003249
THOP1
thimet oligopeptidase 1
chr9_+_116930778 0.667 COL27A1
collagen, type XXVII, alpha 1
chr19_+_1450208 0.663 APC2
adenomatosis polyposis coli 2
chr3_+_113666544 0.651 NM_173570
ZDHHC23
zinc finger, DHHC-type containing 23
chr19_-_59084928 0.643 NM_003422
NM_198055
MZF1

myeloid zinc finger 1

chr6_+_52284948 0.640 NM_018100
EFHC1
EF-hand domain (C-terminal) containing 1
chr16_+_67840976 0.640 NM_018430
TSNAXIP1
translin-associated factor X interacting protein 1
chr16_+_8807186 0.637 ABAT
4-aminobutyrate aminotransferase
chr10_-_103347882 0.637 POLL
polymerase (DNA directed), lambda
chr13_+_37006408 0.637 NM_001111045
NM_003914
CCNA1

cyclin A1

chr20_+_49126947 0.636 PTPN1
protein tyrosine phosphatase, non-receptor type 1
chr20_+_49126857 0.632 NM_002827
PTPN1
protein tyrosine phosphatase, non-receptor type 1
chr22_-_38240246 0.629 ANKRD54
ankyrin repeat domain 54
chr7_-_140340575 0.628 DENND2A
DENN/MADD domain containing 2A
chr8_+_22462267 0.628 KIAA1967
KIAA1967
chrX_+_30671602 0.626 GK
glycerol kinase
chr19_-_55791428 0.621 HSPBP1
HSPA (heat shock 70kDa) binding protein, cytoplasmic cochaperone 1
chr22_-_38240341 0.619 NM_138797
ANKRD54
ankyrin repeat domain 54
chr6_-_70992754 0.614 NM_078485
COL9A1
collagen, type IX, alpha 1
chr15_+_98503938 0.614 ARRDC4
arrestin domain containing 4
chr2_+_232063379 0.614 ARMC9
armadillo repeat containing 9
chr3_-_130745583 0.608 NM_014065
ASTE1
asteroid homolog 1 (Drosophila)
chr2_+_232063378 0.603 ARMC9
armadillo repeat containing 9
chr1_-_163113938 0.602 RGS5
regulator of G-protein signaling 5
chr9_-_131418931 0.602 WDR34
WD repeat domain 34
chr19_-_633474 0.600 POLRMT
polymerase (RNA) mitochondrial (DNA directed)
chr8_+_145703439 0.599 PPP1R16A
protein phosphatase 1, regulatory subunit 16A
chr1_+_37940129 0.597 ZC3H12A
zinc finger CCCH-type containing 12A
chr19_+_58920007 0.596 NM_173548
ZNF584
zinc finger protein 584
chr2_+_48541767 0.596 NM_002158
FOXN2
forkhead box N2
chr20_+_49126920 0.593 PTPN1
protein tyrosine phosphatase, non-receptor type 1
chr4_+_123653856 0.591 NM_001178007
NM_152618
BBS12

Bardet-Biedl syndrome 12

chr10_+_103348040 0.583 NM_015448
DPCD
deleted in primary ciliary dyskinesia homolog (mouse)
chr11_-_28129701 0.582 NM_031217
KIF18A
kinesin family member 18A
chr1_+_161129288 0.579 USP21
ubiquitin specific peptidase 21
chr17_-_7232455 0.577 NM_001005408
NM_032442
NEURL4

neuralized homolog 4 (Drosophila)

chr1_+_42928873 0.572 CCDC30
coiled-coil domain containing 30
chr19_-_55791727 0.571 NM_001130106
NM_012267
HSPBP1

HSPA (heat shock 70kDa) binding protein, cytoplasmic cochaperone 1

chr1_+_37940074 0.569 NM_025079
ZC3H12A
zinc finger CCCH-type containing 12A
chr19_-_55791446 0.565 HSPBP1
HSPA (heat shock 70kDa) binding protein, cytoplasmic cochaperone 1
chr1_+_161129229 0.561 NM_001014443
NM_012475
USP21

ubiquitin specific peptidase 21

chr9_-_131419004 0.560 NM_052844
WDR34
WD repeat domain 34
chr12_+_107168336 0.556 NM_018157
RIC8B
resistance to inhibitors of cholinesterase 8 homolog B (C. elegans)
chr9_+_35829208 0.556 NM_016446
NM_001042589
TMEM8B

transmembrane protein 8B

chr14_-_77279179 0.554 ANGEL1
angel homolog 1 (Drosophila)
chr8_+_38243958 0.552 NM_001199659
NM_144652
LETM2

leucine zipper-EF-hand containing transmembrane protein 2

chr14_-_59931850 0.548 GPR135
G protein-coupled receptor 135
chr15_+_69706619 0.546 NM_004856
NM_138555
KIF23

kinesin family member 23

chr8_-_98290171 0.545 NM_033512
TSPYL5
TSPY-like 5
chr2_+_232063340 0.542 NM_025139
ARMC9
armadillo repeat containing 9
chr14_-_77279242 0.542 NM_015305
ANGEL1
angel homolog 1 (Drosophila)
chr6_-_32145841 0.542 NM_032741
AGPAT1
1-acylglycerol-3-phosphate O-acyltransferase 1 (lysophosphatidic acid acyltransferase, alpha)
chr1_-_52499432 0.540 NM_138417
KTI12
KTI12 homolog, chromatin associated (S. cerevisiae)
chr19_+_58920118 0.533 ZNF584
zinc finger protein 584
chrX_+_48456552 0.530 WDR13
WD repeat domain 13
chr11_+_67056761 0.529 NM_207354
ANKRD13D
ankyrin repeat domain 13 family, member D
chr15_+_55700722 0.529 NM_001198784
FLJ27352
uncharacterized LOC145788
chr8_-_98290072 0.528 TSPYL5
TSPY-like 5
chr19_-_58874078 0.528 NM_001207009
NM_198458
ZNF497

zinc finger protein 497

chr13_+_24463591 0.526 NM_001135816
C1QTNF9B-AS1
C1QTNF9B antisense RNA 1 (non-protein coding)
chr1_+_109656570 0.526 NM_020775
KIAA1324
KIAA1324
chr14_+_74486049 0.525 NM_025057
C14orf45
chromosome 14 open reading frame 45
chrX_+_48456122 0.524 WDR13
WD repeat domain 13
chr22_-_39052579 0.520 NM_001013647
LOC646851
putative uncharacterized protein LOC388900
chrX_+_48456220 0.516 NM_001166426
WDR13
WD repeat domain 13
chr1_+_155108276 0.513 NM_001122837
NM_001122839
NM_018845
SLC50A1


solute carrier family 50 (sugar transporter), member 1


chr22_-_38349533 0.511 NM_032561
NM_001207062
C22orf23

chromosome 22 open reading frame 23

chr11_-_28129646 0.511 KIF18A
kinesin family member 18A
chr10_-_103347978 0.508 NM_001174084
NM_001174085
NM_013274
POLL


polymerase (DNA directed), lambda


chr4_-_122791468 0.504 NM_018190
NM_176824
BBS7

Bardet-Biedl syndrome 7

chr3_+_50306578 0.503 SEMA3B
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B
chr16_+_30773619 0.499 RNF40
ring finger protein 40
chr11_+_67056815 0.495 ANKRD13D
ankyrin repeat domain 13 family, member D
chr18_+_51795848 0.494 NM_007195
POLI
polymerase (DNA directed) iota
chr4_-_156298094 0.493 NM_001039580
MAP9
microtubule-associated protein 9
chr14_+_32798478 0.490 NM_004274
AKAP6
A kinase (PRKA) anchor protein 6
chr19_+_35630391 0.490 NM_005031
FXYD1
FXYD domain containing ion transport regulator 1
chr17_+_38375554 0.487 NM_133264
WIPF2
WAS/WASL interacting protein family, member 2
chr20_+_44420606 0.486 DNTTIP1
deoxynucleotidyltransferase, terminal, interacting protein 1
chr11_+_61447816 0.482 NM_006133
DAGLA
diacylglycerol lipase, alpha
chr18_+_54318561 0.478 NM_015285
NM_052834
WDR7

WD repeat domain 7

chr11_-_28129687 0.476 KIF18A
kinesin family member 18A
chr22_+_31063914 0.476


chr13_+_73356179 0.475 NM_006346
PIBF1
progesterone immunomodulatory binding factor 1
chr14_+_102829351 0.472 TECPR2
tectonin beta-propeller repeat containing 2
chr1_+_155108343 0.471 SLC50A1
solute carrier family 50 (sugar transporter), member 1
chr5_+_122181159 0.471 NM_014035
SNX24
sorting nexin 24
chr1_+_40627031 0.468 NM_012421
RLF
rearranged L-myc fusion
chr20_+_44420575 0.467 NM_052951
DNTTIP1
deoxynucleotidyltransferase, terminal, interacting protein 1
chr21_+_43919741 0.466 NM_018964
SLC37A1
solute carrier family 37 (glycerol-3-phosphate transporter), member 1
chr17_-_41132544 0.461 NM_001136042
NM_001142653
NM_001142654
AARSD1


alanyl-tRNA synthetase domain containing 1


chr3_-_118753428 0.461 IGSF11
immunoglobulin superfamily, member 11
chr3_-_13114547 0.459 NM_001134382
IQSEC1
IQ motif and Sec7 domain 1
chr11_+_86085777 0.459 NM_001156474
NM_021827
CCDC81

coiled-coil domain containing 81

chr1_-_16563658 0.456 NM_030907
RSG1
REM2 and RAB-like small GTPase 1
chr3_-_118753665 0.455 NM_001015887
IGSF11
immunoglobulin superfamily, member 11
chr2_-_64371444 0.452 NM_020651
PELI1
pellino homolog 1 (Drosophila)
chr16_+_30064470 0.449 ALDOA
aldolase A, fructose-bisphosphate
chr19_+_1450117 0.449 NM_005883
APC2
adenomatosis polyposis coli 2
chrX_+_30671537 0.446 GK
glycerol kinase
chr2_+_44001177 0.445 NM_001193464
NM_015522
NM_016008
DYNC2LI1


dynein, cytoplasmic 2, light intermediate chain 1


chr19_+_41869848 0.445 NM_001098825
TMEM91
transmembrane protein 91
chr20_+_34203746 0.445 NM_003116
SPAG4
sperm associated antigen 4
chr22_+_31892084 0.444 NM_001007467
NM_014775
SFI1

Sfi1 homolog, spindle assembly associated (yeast)

chr16_-_75590107 0.444 NM_001077416
NM_001077418
NM_001077419
TMEM231


transmembrane protein 231


chr6_-_159065739 0.440 NM_006519
DYNLT1
dynein, light chain, Tctex-type 1
chr7_-_129845216 0.440 NM_032842
TMEM209
transmembrane protein 209
chr22_+_37447615 0.439 NM_024681
KCTD17
potassium channel tetramerisation domain containing 17
chr14_+_24838301 0.439 NM_001198966
NFATC4
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4
chr20_+_44420610 0.437 DNTTIP1
deoxynucleotidyltransferase, terminal, interacting protein 1
chr14_-_70546863 0.435 NM_182936
NM_001130417
SLC8A3

solute carrier family 8 (sodium/calcium exchanger), member 3

chr3_+_48507209 0.433 NM_016381
NM_033629
TREX1

three prime repair exonuclease 1

chr16_+_30064410 0.432 NM_000034
ALDOA
aldolase A, fructose-bisphosphate
chr19_-_50528576 0.432 VRK3
vaccinia related kinase 3
chr16_-_23464451 0.429 NM_153603
COG7
component of oligomeric golgi complex 7
chr9_+_124461365 0.428 DAB2IP
DAB2 interacting protein
chrX_-_119077568 0.428 NM_024528
NKAP
NFKB activating protein
chr1_+_40627066 0.427 RLF
rearranged L-myc fusion
chr4_-_186125072 0.425 NM_020827
KIAA1430
KIAA1430
chr1_-_118727780 0.424 NM_206996
SPAG17
sperm associated antigen 17
chr11_-_66360485 0.420 NM_018219
CCDC87
coiled-coil domain containing 87
chr1_-_231376856 0.419 NM_152379
C1orf131
chromosome 1 open reading frame 131
chr3_-_113775363 0.416 NM_020817
KIAA1407
KIAA1407
chr19_-_375969 0.416 NM_016585
NM_199202
THEG

Theg homolog (mouse)

chr17_-_1012257 0.415 NM_001092
ABR
active BCR-related gene
chr7_+_99006650 0.414 BUD31
BUD31 homolog (S. cerevisiae)

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
2.50 1.29e-02 GO:0007017 microtubule-based process

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
2.38 9.74e-09 GO:0015630 microtubule cytoskeleton
6.91 1.35e-08 GO:0005930 axoneme
4.07 1.62e-08 GO:0005929 cilium
3.11 1.06e-07 GO:0005874 microtubule
7.06 5.27e-06 GO:0035085 cilium axoneme
5.56 5.39e-06 GO:0044441 cilium part
2.61 2.36e-05 GO:0005815 microtubule organizing center
5.69 7.46e-04 GO:0005932 microtubule basal body
1.13 7.98e-04 GO:0044424 intracellular part
1.18 8.35e-04 GO:0005737 cytoplasm
1.12 2.28e-03 GO:0005622 intracellular
1.55 2.57e-03 GO:0005856 cytoskeleton
1.24 3.37e-03 GO:0044422 organelle part
1.65 5.34e-03 GO:0044430 cytoskeletal part
2.54 6.46e-03 GO:0005813 centrosome
1.14 8.69e-03 GO:0043226 organelle
4.84 1.02e-02 GO:0019861 flagellum
1.23 1.08e-02 GO:0044446 intracellular organelle part
2.06 1.31e-02 GO:0044463 cell projection part
1.13 1.31e-02 GO:0043229 intracellular organelle
3.32 2.61e-02 GO:0005875 microtubule associated complex
1.33 3.60e-02 GO:0043228 non-membrane-bounded organelle
1.33 3.60e-02 GO:0043232 intracellular non-membrane-bounded organelle

Gene overrepresentation in function category:

enrichment   p-value GO term description
3.06 4.49e-02 GO:0016779 nucleotidyltransferase activity
5.99 4.62e-02 GO:0003887 DNA-directed DNA polymerase activity