Motif ID: RXRG_dimer.p3

Z-value: 0.809


Transcription factors associated with RXRG_dimer.p3:

Gene SymbolEntrez IDGene Name
NR1H2 7376 nuclear receptor subfamily 1, group H, member 2
PPARA 5465 peroxisome proliferator-activated receptor alpha
PPARG 5468 peroxisome proliferator-activated receptor gamma
RXRA 6256 retinoid X receptor, alpha
RXRB 6257 retinoid X receptor, beta
RXRG 6258 retinoid X receptor, gamma

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.p-valuePlot
RXRBchr6_-_33168448-0.672.8e-04Click!
RXRAchr9_+_1372183130.349.5e-02Click!
NR1H2chr19_+_50879681-0.349.6e-02Click!
PPARAchr22_+_46546690-0.203.3e-01Click!
RXRGchr1_-_165414499-0.144.9e-01Click!
PPARGchr3_+_12329332-0.087.0e-01Click!


Activity profile for motif RXRG_dimer.p3.

activity profile for motif RXRG_dimer.p3


Sorted Z-values histogram for motif RXRG_dimer.p3

Sorted Z-values for motif RXRG_dimer.p3



Network of associatons between targets according to the STRING database.



First level regulatory network of RXRG_dimer.p3

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr1_+_61547625 3.133 NM_001134673
NM_005595
NFIA

nuclear factor I/A

chr8_+_144816287 2.333 LOC100128338
uncharacterized LOC100128338
chr4_+_30721865 2.165 NM_032456
NM_001173523
NM_002589
NM_032457
PCDH7



protocadherin 7



chr1_+_101491401 1.874


chr6_-_146285225 1.848 NM_001042683
NM_173082
SHPRH

SNF2 histone linker PHD RING helicase

chr12_-_6665220 1.576 NM_001039670
NM_001193457
NM_080730
IFFO1


intermediate filament family orphan 1


chr8_-_124286489 1.537 ZHX1
zinc fingers and homeoboxes 1
chr6_+_143999058 1.485 NM_001100164
NM_001100165
PHACTR2

phosphatase and actin regulator 2

chr1_+_78354199 1.430 NM_001172309
NM_144573
NEXN

nexilin (F actin binding protein)

chr2_+_109237679 1.413 NM_001193484
LIMS1
LIM and senescent cell antigen-like domains 1
chr4_-_102268333 1.352 PPP3CA
protein phosphatase 3, catalytic subunit, alpha isozyme
chr13_+_100741268 1.290 NM_000282
NM_001127692
NM_001178004
PCCA


propionyl CoA carboxylase, alpha polypeptide


chr12_+_14538232 1.249 ATF7IP
activating transcription factor 7 interacting protein
chr4_+_30722191 1.215 PCDH7
protocadherin 7
chr14_+_24867926 1.144 NM_025081
NYNRIN
NYN domain and retroviral integrase containing
chr2_+_159313407 1.130 PKP4
plakophilin 4
chr11_+_118868841 1.112 NM_198489
CCDC84
coiled-coil domain containing 84
chr4_+_140587086 1.087 MGST2
microsomal glutathione S-transferase 2
chr7_-_65447206 1.050 GUSB
glucuronidase, beta
chr17_+_7812703 1.023 CHD3
chromodomain helicase DNA binding protein 3
chr11_+_86013252 0.997 NM_016401
C11orf73
chromosome 11 open reading frame 73
chr22_-_29784430 0.995 AP1B1
adaptor-related protein complex 1, beta 1 subunit
chr2_+_178257371 0.986 NM_003659
AGPS
alkylglycerone phosphate synthase
chr22_-_29784568 0.956 NM_001127
NM_001166019
NM_145730
AP1B1


adaptor-related protein complex 1, beta 1 subunit


chr7_-_65447162 0.911 GUSB
glucuronidase, beta
chr1_-_101491308 0.907 NM_001077394
NM_001077395
NM_015958
DPH5


DPH5 homolog (S. cerevisiae)


chr12_-_118810712 0.855 NM_016281
TAOK3
TAO kinase 3
chr22_-_24059436 0.852


chr2_+_109065665 0.824 GCC2
GRIP and coiled-coil domain containing 2
chr7_-_65447187 0.815 GUSB
glucuronidase, beta
chr19_+_6372805 0.806 ALKBH7
alkB, alkylation repair homolog 7 (E. coli)
chr18_-_46477080 0.799 NM_001190821
NM_005904
SMAD7

SMAD family member 7

chr20_+_36661849 0.795 NM_021215
RPRD1B
regulation of nuclear pre-mRNA domain containing 1B
chr22_-_51021200 0.792 CHKB
choline kinase beta
chr19_+_6372720 0.774 ALKBH7
alkB, alkylation repair homolog 7 (E. coli)
chr7_-_65447233 0.770 NM_000181
GUSB
glucuronidase, beta
chr11_+_118868861 0.760 CCDC84
coiled-coil domain containing 84
chr2_-_178257380 0.747 LOC100130691
uncharacterized LOC100130691
chr2_+_109065576 0.730 NM_181453
GCC2
GRIP and coiled-coil domain containing 2
chr20_-_20033005 0.723 CRNKL1
crooked neck pre-mRNA splicing factor-like 1 (Drosophila)
chr11_+_118230292 0.720 NM_001204077
NM_004788
UBE4A

ubiquitination factor E4A

chr22_-_24059502 0.692 GUSBP11
glucuronidase, beta pseudogene 11
chr15_+_96873845 0.691 NM_021005
NR2F2
nuclear receptor subfamily 2, group F, member 2
chr9_+_104296120 0.690 NM_019592
RNF20
ring finger protein 20
chr22_-_24059524 0.688 GUSBP11
glucuronidase, beta pseudogene 11
chr12_-_54121203 0.677 NM_001143682
NM_020898
CALCOCO1

calcium binding and coiled-coil domain 1

chr19_-_48867149 0.668 NM_018273
TMEM143
transmembrane protein 143
chr2_+_28113612 0.647 BRE
brain and reproductive organ-expressed (TNFRSF1A modulator)
chr2_+_28113655 0.643 BRE
brain and reproductive organ-expressed (TNFRSF1A modulator)
chr20_-_36661822 0.640 NM_014657
TTI1
TELO2 interacting protein 1
chr8_+_22853360 0.622 NM_001160037
RHOBTB2
Rho-related BTB domain containing 2
chr18_+_29598444 0.602 NM_017831
RNF125
ring finger protein 125
chr2_+_28113598 0.581 BRE
brain and reproductive organ-expressed (TNFRSF1A modulator)
chr18_+_54318561 0.577 NM_015285
NM_052834
WDR7

WD repeat domain 7

chr19_+_50016500 0.561 FCGRT
Fc fragment of IgG, receptor, transporter, alpha
chr2_+_138721807 0.548 NM_001024074
NM_001024075
NM_006895
HNMT


histamine N-methyltransferase


chr20_-_44485953 0.543 NM_005469
ACOT8
acyl-CoA thioesterase 8
chr19_+_50016490 0.533 FCGRT
Fc fragment of IgG, receptor, transporter, alpha
chr10_-_21814610 0.529 NM_207371
C10orf140
chromosome 10 open reading frame 140
chr17_+_73996986 0.517 NM_001258
CDK3
cyclin-dependent kinase 3
chr1_-_76397975 0.512 NM_080868
ASB17
ankyrin repeat and SOCS box containing 17
chr3_-_14166228 0.512 CHCHD4
coiled-coil-helix-coiled-coil-helix domain containing 4
chr19_+_6372443 0.505 NM_032306
ALKBH7
alkB, alkylation repair homolog 7 (E. coli)
chr5_+_172484353 0.504 C5orf41
chromosome 5 open reading frame 41
chr5_-_42811959 0.499 NM_001085486
NM_001093726
NM_005410
SEPP1


selenoprotein P, plasma, 1


chr3_-_14166246 0.475 CHCHD4
coiled-coil-helix-coiled-coil-helix domain containing 4
chr11_+_86748870 0.473 NM_001168724
NM_022918
TMEM135

transmembrane protein 135

chr3_-_48936227 0.470 NM_000387
SLC25A20
solute carrier family 25 (carnitine/acylcarnitine translocase), member 20
chr19_-_55580896 0.463 NM_138412
RDH13
retinol dehydrogenase 13 (all-trans/9-cis)
chr10_-_103815868 0.460 NM_024541
C10orf76
chromosome 10 open reading frame 76
chr5_+_42548314 0.456 NM_001242403
GHR
growth hormone receptor
chr22_+_30163351 0.451 NM_001003684
NM_013387
UQCR10

ubiquinol-cytochrome c reductase, complex III subunit X

chr16_-_89266528 0.442 NM_001242757
SLC22A31
solute carrier family 22, member 31
chr2_+_28113481 0.441 NM_199193
NM_199194
NM_004899
NM_199191
NM_199192
BRE




brain and reproductive organ-expressed (TNFRSF1A modulator)




chr14_+_101295409 0.438 MEG3
maternally expressed 3 (non-protein coding)
chr1_+_45274153 0.437 NM_001136537
BTBD19
BTB (POZ) domain containing 19
chr2_-_219432955 0.433 NM_020935
USP37
ubiquitin specific peptidase 37
chr20_+_36662138 0.432 RPRD1B
regulation of nuclear pre-mRNA domain containing 1B
chr1_-_50489489 0.426 AGBL4
ATP/GTP binding protein-like 4
chr3_-_14166292 0.422 CHCHD4
coiled-coil-helix-coiled-coil-helix domain containing 4
chr3_-_14166370 0.422 NM_001098502
NM_144636
CHCHD4

coiled-coil-helix-coiled-coil-helix domain containing 4

chr7_+_100663360 0.421 NM_001040105
MUC17
mucin 17, cell surface associated
chr22_+_50585483 0.409 NM_001164106
MOV10L1
Mov10l1, Moloney leukemia virus 10-like 1, homolog (mouse)
chr11_+_118230348 0.405 UBE4A
ubiquitination factor E4A
chr2_+_178257488 0.404 AGPS
alkylglycerone phosphate synthase
chr19_+_54606141 0.395 NM_004542
NDUFA3
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 3, 9kDa
chr17_-_7123368 0.386 NM_001365
DLG4
discs, large homolog 4 (Drosophila)
chr9_+_115142395 0.375 HSDL2
hydroxysteroid dehydrogenase like 2
chr6_-_108395939 0.372 NM_014028
OSTM1
osteopetrosis associated transmembrane protein 1
chr15_+_57210852 0.365 TCF12
transcription factor 12
chr9_+_115142188 0.365 NM_001195822
NM_032303
HSDL2

hydroxysteroid dehydrogenase like 2

chr12_-_118810550 0.362 TAOK3
TAO kinase 3
chr8_+_96037186 0.361 NM_152416
C8orf38
chromosome 8 open reading frame 38
chr19_+_50016435 0.346 NM_004107
FCGRT
Fc fragment of IgG, receptor, transporter, alpha
chr22_-_51021255 0.344 CHKB
choline kinase beta
chr5_+_92918924 0.342 NM_005654
NR2F1
nuclear receptor subfamily 2, group F, member 1
chr6_-_31138180 0.340 NM_002701
POU5F1
POU5F1B
POU5F1P3
POU5F1P4
POU class 5 homeobox 1
POU class 5 homeobox 1B
POU class 5 homeobox 1 pseudogene 3
POU class 5 homeobox 1 pseudogene 4
chr19_-_38806381 0.339 NM_001039671
NM_001145461
NM_001145462
YIF1B


Yip1 interacting factor homolog B (S. cerevisiae)


chr7_-_72936538 0.334 BAZ1B
bromodomain adjacent to zinc finger domain, 1B
chr2_+_207024614 0.330 EEF1B2
eukaryotic translation elongation factor 1 beta 2
chr8_-_124286566 0.328 NM_001204180
NM_001017926
NM_007222
ZHX1-C8ORF76
ZHX1

ZHX1-C8ORF76 readthrough
zinc fingers and homeoboxes 1

chr12_+_107168336 0.322 NM_018157
RIC8B
resistance to inhibitors of cholinesterase 8 homolog B (C. elegans)
chr4_+_159593233 0.305 NM_004453
ETFDH
electron-transferring-flavoprotein dehydrogenase
chr16_-_30546145 0.303 NM_023931
ZNF747
zinc finger protein 747
chr15_+_57210823 0.291 NM_003205
NM_207036
NM_207037
NM_207038
TCF12



transcription factor 12



chr12_+_67663364 0.291 CAND1
cullin-associated and neddylation-dissociated 1
chr10_-_52645384 0.286 A1CF
APOBEC1 complementation factor
chr14_-_106174914 0.280 IGHA1
immunoglobulin heavy constant alpha 1
chr10_-_119805673 0.279 NM_014904
RAB11FIP2
RAB11 family interacting protein 2 (class I)
chrX_-_153191686 0.274 ARHGAP4
Rho GTPase activating protein 4
chr6_-_108395854 0.270 OSTM1
osteopetrosis associated transmembrane protein 1
chr20_+_54967572 0.267 NM_001324
CSTF1
cleavage stimulation factor, 3' pre-RNA, subunit 1, 50kDa
chr7_-_74306672 0.267 STAG3L2
stromal antigen 3-like 2
chr2_+_219646448 0.257 NM_000784
CYP27A1
cytochrome P450, family 27, subfamily A, polypeptide 1
chr2_-_176046120 0.256 NM_001002258
NM_001190329
NM_001689
ATP5G3


ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C3 (subunit 9)


chr1_-_155881163 0.255 NM_006912
RIT1
Ras-like without CAAX 1
chr12_+_56624500 0.249 NM_001135195
SLC39A5
solute carrier family 39 (metal ion transporter), member 5
chr2_+_207024330 0.246 EEF1B2
eukaryotic translation elongation factor 1 beta 2
chr1_-_95538443 0.245 NM_144988
ALG14
asparagine-linked glycosylation 14 homolog (S. cerevisiae)
chr7_-_107204705 0.245 NM_001161520
NM_006348
NM_181733
COG5


component of oligomeric golgi complex 5


chr4_+_90816002 0.243 NM_007351
MMRN1
multimerin 1
chr4_+_109541721 0.242 NM_000995
NM_033625
RPL34

ribosomal protein L34

chr18_+_47340328 0.240


chr1_+_2005083 0.238 NM_001033581
PRKCZ
protein kinase C, zeta
chr2_+_207024317 0.236 NM_001037663
NM_001959
NM_021121
EEF1B2


eukaryotic translation elongation factor 1 beta 2


chr1_+_197881618 0.231 NM_001014434
LHX9
LIM homeobox 9
chr19_+_50016606 0.226 FCGRT
Fc fragment of IgG, receptor, transporter, alpha
chr22_-_51021337 0.225 NM_005198
CHKB
CHKB-CPT1B
choline kinase beta
CHKB-CPT1B readthrough (non-protein coding)
chr22_+_38201113 0.220 NM_005318
H1F0
H1 histone family, member 0
chr22_+_47158517 0.219 NM_014346
TBC1D22A
TBC1 domain family, member 22A
chr1_-_55089068 0.219 NM_176782
FAM151A
family with sequence similarity 151, member A
chr8_+_22436641 0.218 PDLIM2
PDZ and LIM domain 2 (mystique)
chrX_-_18372777 0.218 NM_006089
SCML2
sex comb on midleg-like 2 (Drosophila)
chr2_-_27603249 0.217 NM_001201459
ZNF513
zinc finger protein 513
chrX_-_153191710 0.216 NM_001164741
NM_001666
ARHGAP4

Rho GTPase activating protein 4

chr6_-_108395923 0.213 OSTM1
osteopetrosis associated transmembrane protein 1
chrX_-_153191644 0.212 ARHGAP4
Rho GTPase activating protein 4
chr19_+_1205773 0.211 NM_000455
STK11
serine/threonine kinase 11
chr6_+_142468415 0.207 VTA1
Vps20-associated 1 homolog (S. cerevisiae)
chr8_-_71316006 0.206 NM_006540
NCOA2
nuclear receptor coactivator 2
chr6_-_108395918 0.201 OSTM1
osteopetrosis associated transmembrane protein 1
chr6_+_31926788 0.196 SKIV2L
superkiller viralicidic activity 2-like (S. cerevisiae)
chr19_-_38806546 0.192 NM_001039672
NM_001039673
NM_001145463
YIF1B


Yip1 interacting factor homolog B (S. cerevisiae)


chr1_+_150337145 0.190 RPRD2
regulation of nuclear pre-mRNA domain containing 2
chr20_+_20033157 0.180 NM_015585
C20orf26
chromosome 20 open reading frame 26
chr7_+_193112 0.178 FAM20C
family with sequence similarity 20, member C
chr2_-_28113211 0.176 NM_022128
RBKS
ribokinase
chrX_-_64254592 0.176 NM_001178032
NM_001243804
ZC4H2

zinc finger, C4H2 domain containing

chr12_+_67663147 0.176 CAND1
cullin-associated and neddylation-dissociated 1
chr12_-_95467104 0.173 NM_001032287
NM_001127362
NM_003297
NR2C1


nuclear receptor subfamily 2, group C, member 1


chr7_+_99933734 0.172 PILRB
paired immunoglobin-like type 2 receptor beta
chr18_-_47339854 0.168 ACAA2
acetyl-CoA acyltransferase 2
chr17_+_41150409 0.167 NM_000988
RPL27
ribosomal protein L27
chr6_+_143771779 0.164 NM_003630
PEX3
peroxisomal biogenesis factor 3
chr19_+_46001730 0.164 NM_001080401
PPM1N
protein phosphatase, Mg2+/Mn2+ dependent, 1N (putative)
chr1_-_155881063 0.164 RIT1
Ras-like without CAAX 1
chr17_+_41150465 0.164 RPL27
ribosomal protein L27
chr1_+_160313061 0.161 NM_015331
NCSTN
nicastrin
chr2_-_27603584 0.160 NM_144631
ZNF513
zinc finger protein 513
chr10_-_17171789 0.158 NM_001081
CUBN
cubilin (intrinsic factor-cobalamin receptor)
chr16_-_21436657 0.158 NM_130464
NPIPL3
nuclear pore complex interacting protein-like 3
chr10_+_119806334 0.157 CASC2
cancer susceptibility candidate 2 (non-protein coding)
chr6_+_96025343 0.157 NM_024641
MANEA
mannosidase, endo-alpha
chr20_+_44509847 0.151 NM_080603
ZSWIM1
zinc finger, SWIM-type containing 1
chr8_+_67624941 0.148 SGK3
serum/glucocorticoid regulated kinase family, member 3
chrX_-_122866888 0.147 NM_001081550
THOC2
THO complex 2
chr15_+_57210972 0.144 TCF12
transcription factor 12
chr12_-_7079616 0.142 PHB2
prohibitin 2
chr10_+_75504119 0.139 NM_004922
NM_198597
SEC24C

SEC24 family, member C (S. cerevisiae)

chr11_+_117049838 0.138 NM_001040455
SIDT2
SID1 transmembrane family, member 2
chr19_+_44100734 0.135 NM_001145347
ZNF576
zinc finger protein 576
chr1_-_161039703 0.132 ARHGAP30
Rho GTPase activating protein 30
chr6_+_142468401 0.131 NM_016485
VTA1
Vps20-associated 1 homolog (S. cerevisiae)
chr1_-_161039413 0.131 ARHGAP30
Rho GTPase activating protein 30
chr2_+_198365113 0.130 HSPE1
heat shock 10kDa protein 1 (chaperonin 10)
chr2_+_219283809 0.128 NM_007127
VIL1
villin 1
chr7_+_129015483 0.128 NM_001130722
AHCYL2
adenosylhomocysteinase-like 2
chr6_-_2840683 0.126 SERPINB1
serpin peptidase inhibitor, clade B (ovalbumin), member 1
chr22_+_25003610 0.126 NM_001032365
GGT1
gamma-glutamyltransferase 1
chr2_-_198364522 0.124 HSPD1
heat shock 60kDa protein 1 (chaperonin)
chr19_+_2328628 0.122 NM_001077238
NM_152988
SPPL2B

signal peptide peptidase-like 2B

chr20_+_42187634 0.118 NM_170693
SGK2
serum/glucocorticoid regulated kinase 2
chr2_-_73460326 0.116 NM_032319
PRADC1
protease-associated domain containing 1
chr22_-_31742329 0.114 PATZ1
POZ (BTB) and AT hook containing zinc finger 1
chr10_+_75504145 0.110 SEC24C
SEC24 family, member C (S. cerevisiae)
chr8_-_103666018 0.108 NM_001032282
KLF10
Kruppel-like factor 10
chr22_-_19166276 0.107 SLC25A1
solute carrier family 25 (mitochondrial carrier; citrate transporter), member 1
chr2_-_24307179 0.106 NM_001206802
TP53I3
tumor protein p53 inducible protein 3
chr3_-_14988939 0.104 LOC100505641
uncharacterized LOC100505641
chr1_+_12079552 0.104 MIIP
migration and invasion inhibitory protein
chr22_+_24115035 0.101 NM_005940
MMP11
matrix metallopeptidase 11 (stromelysin 3)
chr14_-_21572374 0.100


chr1_-_173886464 0.100 NM_000488
SERPINC1
serpin peptidase inhibitor, clade C (antithrombin), member 1
chr19_-_39390168 0.100 NM_012237
NM_001193286
NM_030593
SIRT2


sirtuin 2


chr19_+_2328685 0.099 SPPL2B
signal peptide peptidase-like 2B
chr8_-_145550300 0.098 DGAT1
diacylglycerol O-acyltransferase 1
chr18_+_29598787 0.097 RNF125
ring finger protein 125
chr1_-_19578015 0.097 KIAA0090
KIAA0090
chr6_+_142468382 0.097 VTA1
Vps20-associated 1 homolog (S. cerevisiae)
chr9_-_116138340 0.096 NM_031219
HDHD3
haloacid dehalogenase-like hydrolase domain containing 3

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.43 1.00e-02 GO:0044237 cellular metabolic process
1.36 2.54e-02 GO:0008152 metabolic process
1.39 4.27e-02 GO:0044238 primary metabolic process

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
3.95 2.14e-03 GO:0005743 mitochondrial inner membrane
3.62 5.61e-03 GO:0019866 organelle inner membrane
2.10 9.75e-03 GO:0005739 mitochondrion
1.26 1.91e-02 GO:0043231 intracellular membrane-bounded organelle
1.26 2.03e-02 GO:0043227 membrane-bounded organelle
2.51 3.36e-02 GO:0044429 mitochondrial part
2.87 4.05e-02 GO:0005740 mitochondrial envelope
1.22 4.86e-02 GO:0043229 intracellular organelle

Nothing significant found in function category.