Motif ID: SOX17.p2

Z-value: 1.140


Transcription factors associated with SOX17.p2:

Gene SymbolEntrez IDGene Name
SOX17 64321 SRY (sex determining region Y)-box 17

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.p-valuePlot
SOX17chr8_+_55370494-0.048.6e-01Click!


Activity profile for motif SOX17.p2.

activity profile for motif SOX17.p2


Sorted Z-values histogram for motif SOX17.p2

Sorted Z-values for motif SOX17.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of SOX17.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr10_+_102106958 3.178 SCD
stearoyl-CoA desaturase (delta-9-desaturase)
chr10_+_102107074 2.692 SCD
stearoyl-CoA desaturase (delta-9-desaturase)
chr4_+_156680125 2.122 NM_000857
GUCY1B3
guanylate cyclase 1, soluble, beta 3
chr10_+_102106771 2.045 NM_005063
SCD
stearoyl-CoA desaturase (delta-9-desaturase)
chr10_+_102107001 1.868 SCD
stearoyl-CoA desaturase (delta-9-desaturase)
chr10_+_102107256 1.699


chr6_+_160182988 1.458 NM_005891
ACAT2
acetyl-CoA acetyltransferase 2
chr12_+_108909049 1.344 NM_007076
FICD
FIC domain containing
chr14_-_55369163 1.243 NM_000161
NM_001024024
NM_001024070
NM_001024071
GCH1



GTP cyclohydrolase 1



chr2_+_153191830 1.200 FMNL2
formin-like 2
chrX_+_151999565 1.099 NSDHL
NAD(P) dependent steroid dehydrogenase-like
chr9_+_82187469 1.094 TLE4
transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)
chr6_+_160183510 1.066 ACAT2
acetyl-CoA acetyltransferase 2
chr1_-_182360181 1.001 GLUL
glutamate-ammonia ligase
chr20_-_17662704 0.949 RRBP1
ribosome binding protein 1 homolog 180kDa (dog)
chr9_+_91003987 0.944 SPIN1
spindlin 1
chr14_+_103589711 0.943 TNFAIP2
tumor necrosis factor, alpha-induced protein 2
chr11_-_126138789 0.929 SRPR
signal recognition particle receptor (docking protein)
chr4_+_156680603 0.919 GUCY1B3
guanylate cyclase 1, soluble, beta 3
chr1_+_101185195 0.901 NM_001078
NM_001199834
NM_080682
VCAM1


vascular cell adhesion molecule 1


chr12_+_98909405 0.892 TMPO
thymopoietin
chr6_+_111135823 0.884 AMD1
adenosylmethionine decarboxylase 1
chr20_+_42086533 0.874 SRSF6
serine/arginine-rich splicing factor 6
chr9_+_82187599 0.866 TLE4
transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)
chr17_+_26646120 0.856 NM_014573
TMEM97
transmembrane protein 97
chr6_+_142623364 0.850 GPR126
G protein-coupled receptor 126
chr11_-_59383179 0.848 OSBP
oxysterol binding protein
chr14_+_103800548 0.839 EIF5
eukaryotic translation initiation factor 5
chr4_+_55523906 0.833 NM_000222
NM_001093772
KIT

v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog

chr13_+_111855406 0.828 ARHGEF7
Rho guanine nucleotide exchange factor (GEF) 7
chr14_+_103800678 0.828 EIF5
eukaryotic translation initiation factor 5
chr19_+_17420352 0.818 DDA1
DET1 and DDB1 associated 1
chr14_+_63671101 0.810 NM_020663
RHOJ
ras homolog gene family, member J
chr1_+_24286311 0.805 PNRC2
proline-rich nuclear receptor coactivator 2
chr10_-_116444374 0.803 NM_001003407
NM_001003408
ABLIM1

actin binding LIM protein 1

chrX_+_151999605 0.802 NSDHL
NAD(P) dependent steroid dehydrogenase-like
chr1_-_27816667 0.799 WASF2
WAS protein family, member 2
chr2_-_175869910 0.794 NM_001822
NM_001025201
CHN1

chimerin (chimaerin) 1

chr3_+_9439533 0.780 SETD5
SET domain containing 5
chr12_-_6233684 0.774 NM_000552
VWF
von Willebrand factor
chr1_+_24286300 0.768 NM_017761
PNRC2
proline-rich nuclear receptor coactivator 2
chr1_+_25071906 0.766 CLIC4
chloride intracellular channel 4
chr2_+_159313407 0.749 PKP4
plakophilin 4
chr10_-_116444112 0.748 ABLIM1
actin binding LIM protein 1
chr16_+_69726751 0.740 NFAT5
nuclear factor of activated T-cells 5, tonicity-responsive
chr3_-_160167525 0.737 TRIM59
tripartite motif containing 59
chr14_+_103800534 0.729 EIF5
eukaryotic translation initiation factor 5
chr11_-_2162340 0.725 NM_001127598
IGF2
insulin-like growth factor 2 (somatomedin A)
chr3_-_197024879 0.723 DLG1
discs, large homolog 1 (Drosophila)
chr17_-_8534008 0.722 NM_005964
MYH10
myosin, heavy chain 10, non-muscle
chr1_+_25071967 0.716 CLIC4
chloride intracellular channel 4
chr17_-_67138013 0.713 NM_080284
ABCA6
ATP-binding cassette, sub-family A (ABC1), member 6
chr2_-_54198055 0.709


chr6_-_35696359 0.702 NM_001145775
FKBP5
FK506 binding protein 5
chr14_+_32546171 0.701 ARHGAP5
Rho GTPase activating protein 5
chr1_-_236228374 0.689 NID1
nidogen 1
chrX_+_151999510 0.683 NM_001129765
NM_015922
NSDHL

NAD(P) dependent steroid dehydrogenase-like

chr8_+_126010748 0.681 SQLE
squalene epoxidase
chr6_-_11232900 0.674 NEDD9
neural precursor cell expressed, developmentally down-regulated 9
chr6_+_160183062 0.667 ACAT2
acetyl-CoA acetyltransferase 2
chr8_-_101965096 0.660 YWHAZ
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide
chr8_+_126010719 0.654 NM_003129
SQLE
squalene epoxidase
chr1_+_47489239 0.652 NM_178033
CYP4X1
cytochrome P450, family 4, subfamily X, polypeptide 1
chr15_+_62359175 0.650 NM_207322
C2CD4A
C2 calcium-dependent domain containing 4A
chr8_+_81398416 0.650 NM_001105539
NM_023929
ZBTB10

zinc finger and BTB domain containing 10

chr11_+_6897855 0.649 NM_207186
OR10A4
olfactory receptor, family 10, subfamily A, member 4
chr12_-_88974094 0.644 NM_000899
NM_003994
KITLG

KIT ligand

chr4_-_2263808 0.640 MXD4
MAX dimerization protein 4
chr2_-_37898768 0.635 CDC42EP3
CDC42 effector protein (Rho GTPase binding) 3
chr8_+_17396285 0.625 NM_001164771
NM_003046
SLC7A2

solute carrier family 7 (cationic amino acid transporter, y+ system), member 2

chr15_+_39873276 0.624 NM_003246
THBS1
thrombospondin 1
chr1_-_41328002 0.623 NM_133467
CITED4
Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 4
chr7_-_75368216 0.618 HIP1
huntingtin interacting protein 1
chr12_+_110011616 0.612 MVK
mevalonate kinase
chr3_+_196466806 0.611 PAK2
p21 protein (Cdc42/Rac)-activated kinase 2
chr5_-_139780998 0.608


chr13_-_99630243 0.605 NM_001130048
NM_001130050
DOCK9

dedicator of cytokinesis 9

chr11_+_128563955 0.605 FLI1
Friend leukemia virus integration 1
chr1_-_150241210 0.603 APH1A
anterior pharynx defective 1 homolog A (C. elegans)
chr7_+_65338343 0.601 VKORC1L1
vitamin K epoxide reductase complex, subunit 1-like 1
chr17_-_79818444 0.600 P4HB
prolyl 4-hydroxylase, beta polypeptide
chr17_+_65373362 0.597 PITPNC1
phosphatidylinositol transfer protein, cytoplasmic 1
chr19_+_13906207 0.595 NM_023072
ZSWIM4
zinc finger, SWIM-type containing 4
chr1_-_153643456 0.594 ILF2
interleukin enhancer binding factor 2, 45kDa
chr14_+_24641204 0.593 NM_001048205
NM_005132
REC8

REC8 homolog (yeast)

chr4_-_76598558 0.591 G3BP2
GTPase activating protein (SH3 domain) binding protein 2
chr12_+_110011499 0.590 NM_000431
NM_001114185
MVK

mevalonate kinase

chr11_-_57417247 0.588 NM_145008
YPEL4
yippee-like 4 (Drosophila)
chr3_+_99357439 0.584 NM_001850
NM_020351
COL8A1

collagen, type VIII, alpha 1

chr11_-_105892908 0.583 NM_032424
KIAA1826
KIAA1826
chr11_-_59383616 0.579 NM_002556
OSBP
oxysterol binding protein
chr10_-_45474210 0.578 NM_007021
C10orf10
chromosome 10 open reading frame 10
chr17_+_61627976 0.569 DCAF7
DDB1 and CUL4 associated factor 7
chr22_+_44319674 0.566 PNPLA3
patatin-like phospholipase domain containing 3
chr6_-_108279212 0.563 SEC63
SEC63 homolog (S. cerevisiae)
chr19_+_799281 0.562 PTBP1
polypyrimidine tract binding protein 1
chr7_-_75623932 0.560 TMEM120A
transmembrane protein 120A
chr22_+_44319618 0.559 NM_025225
PNPLA3
patatin-like phospholipase domain containing 3
chr19_-_55677919 0.557 NM_178837
C19orf51
chromosome 19 open reading frame 51
chr11_-_126138698 0.556 SRPR
signal recognition particle receptor (docking protein)
chr5_-_95297424 0.552 ELL2
elongation factor, RNA polymerase II, 2
chr14_-_92413738 0.549 FBLN5
fibulin 5
chr1_-_236228382 0.547 NID1
nidogen 1
chr4_+_41614911 0.547 NM_001112719
NM_001112720
LIMCH1

LIM and calponin homology domains 1

chr14_+_24641084 0.546 REC8
REC8 homolog (yeast)
chr1_+_26504024 0.543 CNKSR1
connector enhancer of kinase suppressor of Ras 1
chrX_+_15518899 0.541 NM_203281
BMX
BMX non-receptor tyrosine kinase
chr11_-_59383167 0.537 OSBP
oxysterol binding protein
chr2_-_191872322 0.533 STAT1
signal transducer and activator of transcription 1, 91kDa
chr1_-_153643433 0.532 ILF2
interleukin enhancer binding factor 2, 45kDa
chr16_-_2264776 0.532 NM_001042371
PGP
phosphoglycolate phosphatase
chr2_-_188312872 0.531 NM_005795
CALCRL
calcitonin receptor-like
chr2_-_208031570 0.531 KLF7
Kruppel-like factor 7 (ubiquitous)
chr4_-_185395616 0.530 NM_002199
IRF2
interferon regulatory factor 2
chr7_+_108210308 0.529 DNAJB9
DnaJ (Hsp40) homolog, subfamily B, member 9
chrX_-_15872905 0.528


chr19_+_45504686 0.526 NM_006509
RELB
v-rel reticuloendotheliosis viral oncogene homolog B
chr12_+_51632589 0.522 DAZAP2
DAZ associated protein 2
chr17_-_73389708 0.519 GRB2
growth factor receptor-bound protein 2
chr1_+_155278538 0.516 NM_001135822
NM_001242824
NM_001242825
NM_002004
FDPS



farnesyl diphosphate synthase



chr20_-_17662828 0.515 NM_001042576
NM_004587
RRBP1

ribosome binding protein 1 homolog 180kDa (dog)

chr1_+_29241002 0.515 NM_001166006
EPB41
erythrocyte membrane protein band 4.1 (elliptocytosis 1, RH-linked)
chr5_+_40680042 0.514 PTGER4
prostaglandin E receptor 4 (subtype EP4)
chr14_-_88459459 0.514 GALC
galactosylceramidase
chr14_+_65007163 0.513 NM_021979
HSPA2
heat shock 70kDa protein 2
chr7_-_23509631 0.512


chr2_-_43453724 0.503 ZFP36L2
zinc finger protein 36, C3H type-like 2
chr11_+_75526211 0.503 NM_003369
UVRAG
UV radiation resistance associated gene
chr6_+_126240369 0.501 NM_001199622
NCOA7
nuclear receptor coactivator 7
chr7_+_77167351 0.498 NM_001131008
NM_001131009
PTPN12

protein tyrosine phosphatase, non-receptor type 12

chr16_-_88729487 0.498 NM_002461
MVD
mevalonate (diphospho) decarboxylase
chr11_+_114167168 0.496 NNMT
nicotinamide N-methyltransferase
chr2_-_88926863 0.496 NM_004836
EIF2AK3
eukaryotic translation initiation factor 2-alpha kinase 3
chr7_-_137686812 0.496 CREB3L2
cAMP responsive element binding protein 3-like 2
chr7_-_75368276 0.494 NM_001243198
NM_005338
HIP1

huntingtin interacting protein 1

chr11_+_75526236 0.494 UVRAG
UV radiation resistance associated gene
chrX_-_15872921 0.493 AP1S2
adaptor-related protein complex 1, sigma 2 subunit
chr4_+_41614933 0.492 LIMCH1
LIM and calponin homology domains 1
chr7_+_65338349 0.488 VKORC1L1
vitamin K epoxide reductase complex, subunit 1-like 1
chr5_+_108084638 0.487 FER
fer (fps/fes related) tyrosine kinase
chr1_+_155278727 0.486 FDPS
farnesyl diphosphate synthase
chr15_+_84115979 0.486 NM_003027
SH3GL3
SH3-domain GRB2-like 3
chr1_-_153643428 0.485 ILF2
interleukin enhancer binding factor 2, 45kDa
chr5_+_121647773 0.479 NM_001242935
NM_005460
SNCAIP

synuclein, alpha interacting protein

chr19_+_8455265 0.476 RAB11B
RAB11B, member RAS oncogene family
chr10_+_31610063 0.476 NM_001128128
NM_001174094
ZEB1

zinc finger E-box binding homeobox 1

chr1_-_153643417 0.474 ILF2
interleukin enhancer binding factor 2, 45kDa
chr1_+_155278677 0.473 NM_001135821
FDPS
farnesyl diphosphate synthase
chr1_+_203274646 0.473 NM_006763
BTG2
BTG family, member 2
chr19_+_8455243 0.472 RAB11B
RAB11B, member RAS oncogene family
chr19_+_797444 0.470 PTBP1
polypyrimidine tract binding protein 1
chr21_-_35987144 0.470 NM_004414
RCAN1
regulator of calcineurin 1
chr1_-_153643474 0.465 NM_004515
ILF2
interleukin enhancer binding factor 2, 45kDa
chr1_-_236228476 0.464 NM_002508
NID1
nidogen 1
chr6_-_11232883 0.460 NEDD9
neural precursor cell expressed, developmentally down-regulated 9
chr5_-_43313581 0.459 NM_001098272
NM_002130
HMGCS1

3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)

chr8_+_27491384 0.459 SCARA3
scavenger receptor class A, member 3
chr15_-_59041777 0.458 ADAM10
ADAM metallopeptidase domain 10
chr9_-_123476578 0.457 NM_001080497
MEGF9
multiple EGF-like-domains 9
chr4_+_166248816 0.454 NM_001017369
NM_006745
MSMO1

methylsterol monooxygenase 1

chr11_+_55944093 0.451 NM_001005492
OR5J2
olfactory receptor, family 5, subfamily J, member 2
chr17_+_61627841 0.451 DCAF7
DDB1 and CUL4 associated factor 7
chrX_+_41193409 0.450 DDX3X
DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, X-linked
chr18_-_53257033 0.449 NM_001243227
NM_001243228
TCF4

transcription factor 4

chr1_+_209602164 0.447 NM_001104548
MIR205HG
MIR205 host gene (non-protein coding)
chr17_+_61627850 0.447 DCAF7
DDB1 and CUL4 associated factor 7
chr11_-_126138824 0.445 NM_001177842
NM_003139
SRPR

signal recognition particle receptor (docking protein)

chr5_-_16936290 0.445 MYO10
myosin X
chr17_+_61627916 0.445 DCAF7
DDB1 and CUL4 associated factor 7
chr2_+_85766286 0.441 MAT2A
methionine adenosyltransferase II, alpha
chr15_+_67418053 0.440 NM_001145102
SMAD3
SMAD family member 3
chr7_+_128379400 0.439 CALU
calumenin
chr11_+_114167197 0.438 NNMT
nicotinamide N-methyltransferase
chr1_+_12834983 0.436 NM_001080830
PRAMEF12
PRAME family member 12
chr11_-_560706 0.434 NM_173573
C11orf35
chromosome 11 open reading frame 35
chr9_-_74525846 0.434 FAM108B1
family with sequence similarity 108, member B1
chr15_+_41625152 0.433 NUSAP1
nucleolar and spindle associated protein 1
chr15_+_84116172 0.432 SH3GL3
SH3-domain GRB2-like 3
chr7_+_128379395 0.431 CALU
calumenin
chrX_-_77041486 0.429 ATRX
alpha thalassemia/mental retardation syndrome X-linked
chr4_-_2263706 0.428 NM_006454
MXD4
MAX dimerization protein 4
chr5_+_139781450 0.427 ANKHD1-EIF4EBP3
ANKHD1
ANKHD1-EIF4EBP3 readthrough
ankyrin repeat and KH domain containing 1
chr6_+_32939371 0.427 NM_001199455
BRD2
bromodomain containing 2
chr14_-_65569056 0.426 MAX
MYC associated factor X
chr9_+_34652125 0.426 NM_001142784
IL11RA
interleukin 11 receptor, alpha
chr7_-_137686778 0.425 CREB3L2
cAMP responsive element binding protein 3-like 2
chr6_+_31430955 0.424 HCP5
HLA complex P5 (non-protein coding)
chr1_-_16161279 0.424


chr2_+_54683276 0.419 NM_003128
SPTBN1
spectrin, beta, non-erythrocytic 1
chr6_-_11232901 0.419 NM_006403
NM_182966
NEDD9

neural precursor cell expressed, developmentally down-regulated 9

chr5_-_43313492 0.418 HMGCS1
3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
chr1_-_41328019 0.417 CITED4
Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 4
chr2_-_188419049 0.416 TFPI
tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
chr14_+_85996512 0.415 FLRT2
fibronectin leucine rich transmembrane protein 2
chr12_-_24715349 0.415 NM_152989
SOX5
SRY (sex determining region Y)-box 5
chr1_-_157108169 0.414 NM_005240
NM_001145312
ETV3

ets variant 3

chr7_+_128379452 0.414 CALU
calumenin
chr2_-_204399906 0.413 NM_203365
NM_213589
RAPH1

Ras association (RalGDS/AF-6) and pleckstrin homology domains 1

chr6_-_136610894 0.413 BCLAF1
BCL2-associated transcription factor 1
chr1_-_935352 0.412 HES4
hairy and enhancer of split 4 (Drosophila)

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.98 6.56e-04 GO:0030029 actin filament-based process
1.98 4.54e-03 GO:0030036 actin cytoskeleton organization
1.21 6.95e-03 GO:0032502 developmental process
1.28 2.69e-02 GO:0030154 cell differentiation
1.28 2.83e-02 GO:0048869 cellular developmental process
1.20 3.31e-02 GO:0007275 multicellular organismal development

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.13 3.26e-02 GO:0005634 nucleus

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.07 6.73e-04 GO:0005488 binding
1.12 2.27e-03 GO:0005515 protein binding
1.76 6.06e-03 GO:0003779 actin binding
1.38 2.90e-02 GO:0001071 nucleic acid binding transcription factor activity
1.38 2.90e-02 GO:0003700 sequence-specific DNA binding transcription factor activity