Motif ID: SOX5.p2

Z-value: 1.296


Transcription factors associated with SOX5.p2:

Gene SymbolEntrez IDGene Name
SOX5 6660 SRY (sex determining region Y)-box 5

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.p-valuePlot
SOX5chr12_-_241039530.242.5e-01Click!


Activity profile for motif SOX5.p2.

activity profile for motif SOX5.p2


Sorted Z-values histogram for motif SOX5.p2

Sorted Z-values for motif SOX5.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of SOX5.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr2_-_225266710 7.991 NM_001122779
NM_024785
FAM124B

family with sequence similarity 124B

chr8_-_93075190 5.420 NM_004349
RUNX1T1
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
chr7_-_27205148 4.987 NM_152739
HOXA9
homeobox A9
chr9_+_127420690 4.681 MIR181A2HG
MIR181A2 host gene (non-protein coding)
chr20_-_45985411 4.624 NM_012408
NM_183047
NM_183048
ZMYND8


zinc finger, MYND-type containing 8


chr2_-_188312872 4.181 NM_005795
CALCRL
calcitonin receptor-like
chr6_-_13408368 4.123 NM_001242630
GFOD1
glucose-fructose oxidoreductase domain containing 1
chr12_-_42877743 3.977 PRICKLE1
prickle homolog 1 (Drosophila)
chr8_-_38205652 3.567 WHSC1L1
Wolf-Hirschhorn syndrome candidate 1-like 1
chr13_-_48987652 3.566 NM_001162498
LPAR6
lysophosphatidic acid receptor 6
chr12_-_42877785 3.565 NM_001144882
NM_001144883
PRICKLE1

prickle homolog 1 (Drosophila)

chr1_+_163038564 3.339 NM_005613
RGS4
regulator of G-protein signaling 4
chr9_-_98268866 3.320 PTCH1
patched 1
chr8_-_93115453 3.280 NM_001198633
NM_175634
RUNX1T1

runt-related transcription factor 1; translocated to, 1 (cyclin D-related)

chr17_+_65822206 3.277 BPTF
bromodomain PHD finger transcription factor
chr4_-_101439071 3.226 NM_001159694
NM_016242
EMCN

endomucin

chr8_-_93029864 3.059 NM_175636
RUNX1T1
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
chr7_-_11871735 3.028 NM_015204
THSD7A
thrombospondin, type I, domain containing 7A
chr17_+_65822242 3.000 BPTF
bromodomain PHD finger transcription factor
chr4_+_41614725 2.861 LIMCH1
LIM and calponin homology domains 1
chr18_+_72922725 2.806 NM_005786
TSHZ1
teashirt zinc finger homeobox 1
chr7_+_30960914 2.743 NM_001185060
NM_001185061
NM_001185062
AQP1


aquaporin 1 (Colton blood group)


chr13_+_53035227 2.741 CKAP2
cytoskeleton associated protein 2
chr12_+_27397077 2.709 NM_015000
STK38L
serine/threonine kinase 38 like
chr6_+_122720750 2.613 HSF2
heat shock transcription factor 2
chr12_+_53443834 2.568 NM_170754
TENC1
tensin like C1 domain containing phosphatase (tensin 2)
chr4_+_41614933 2.517 LIMCH1
LIM and calponin homology domains 1
chr3_-_18480203 2.491 NM_001131010
SATB1
SATB homeobox 1
chr6_+_122720685 2.470 NM_001135564
NM_001243094
NM_004506
HSF2


heat shock transcription factor 2


chr17_+_58677603 2.465 PPM1D
protein phosphatase, Mg2+/Mn2+ dependent, 1D
chr7_-_27205123 2.386 HOXA9
homeobox A9
chr2_+_203499819 2.365 NM_173511
FAM117B
family with sequence similarity 117, member B
chrX_-_10645726 2.352 NM_001098624
MID1
midline 1 (Opitz/BBB syndrome)
chr13_+_103459495 2.347 NM_001204425
BIVM-ERCC5
BIVM
BIVM-ERCC5 readthrough
basic, immunoglobulin-like variable motif containing
chr20_+_42543417 2.337 NM_001098797
TOX2
TOX high mobility group box family member 2
chr1_+_87797371 2.329 LMO4
LIM domain only 4
chr4_+_41614911 2.318 NM_001112719
NM_001112720
LIMCH1

LIM and calponin homology domains 1

chr1_+_87794576 2.292 LMO4
LIM domain only 4
chr1_+_61869699 2.282 NFIA
nuclear factor I/A
chr10_+_99079017 2.264 NM_005479
FRAT1
frequently rearranged in advanced T-cell lymphomas
chr6_+_119215240 2.198 NM_014034
ASF1A
ASF1 anti-silencing function 1 homolog A (S. cerevisiae)
chr4_-_186732208 2.195 NM_001145671
SORBS2
sorbin and SH3 domain containing 2
chr5_+_61874561 2.172 NM_181506
LRRC70
leucine rich repeat containing 70
chr6_-_111888520 2.160 NM_001164283
TRAF3IP2
TRAF3 interacting protein 2
chr18_+_42260774 2.150 NM_015559
SETBP1
SET binding protein 1
chr3_+_107096187 2.124 NM_032600
CCDC54
coiled-coil domain containing 54
chr4_-_186732047 2.123 NM_001145672
SORBS2
sorbin and SH3 domain containing 2
chr3_-_149051258 2.112 NM_001184723
NM_138786
TM4SF18

transmembrane 4 L six family member 18

chr10_-_116444374 2.107 NM_001003407
NM_001003408
ABLIM1

actin binding LIM protein 1

chr14_-_92413738 2.022 FBLN5
fibulin 5
chr9_-_14314036 1.996 NM_001190737
NM_005596
NFIB

nuclear factor I/B

chr1_+_150337145 1.987 RPRD2
regulation of nuclear pre-mRNA domain containing 2
chr11_+_22696318 1.960 NM_005256
GAS2
growth arrest-specific 2
chr1_+_26437655 1.916 NM_001243532
PDIK1L
PDLIM1 interacting kinase 1 like
chr4_+_41540320 1.915 LIMCH1
LIM and calponin homology domains 1
chr4_+_41540187 1.910 LIMCH1
LIM and calponin homology domains 1
chr1_+_84630575 1.909 NM_001242860
NM_001242861
PRKACB

protein kinase, cAMP-dependent, catalytic, beta

chr13_-_48987247 1.895 LPAR6
lysophosphatidic acid receptor 6
chr1_+_84647342 1.894 NM_001242862
PRKACB
protein kinase, cAMP-dependent, catalytic, beta
chr3_+_132036210 1.894 NM_001099
NM_001134194
ACPP

acid phosphatase, prostate

chr13_-_48987017 1.866 LPAR6
lysophosphatidic acid receptor 6
chr17_+_58677489 1.742 NM_003620
PPM1D
protein phosphatase, Mg2+/Mn2+ dependent, 1D
chr8_-_57123827 1.712 PLAG1
pleiomorphic adenoma gene 1
chr3_-_15839674 1.707 NM_001195098
ANKRD28
ankyrin repeat domain 28
chr12_+_14538232 1.694 ATF7IP
activating transcription factor 7 interacting protein
chr1_+_150336584 1.661 RPRD2
regulation of nuclear pre-mRNA domain containing 2
chr14_-_92414004 1.649 NM_006329
FBLN5
fibulin 5
chr9_+_79074067 1.627 NM_001097633
NM_001490
GCNT1

glucosaminyl (N-acetyl) transferase 1, core 2

chr7_+_89843133 1.626 NM_001040666
STEAP2
STEAP family member 2, metalloreductase
chr18_-_53177999 1.623 NM_001243231
TCF4
transcription factor 4
chr6_-_79675672 1.616 PHIP
pleckstrin homology domain interacting protein
chr15_-_93277303 1.615 FAM174B
family with sequence similarity 174, member B
chr1_+_61547388 1.590 NM_001145512
NFIA
nuclear factor I/A
chr8_-_57123858 1.589 NM_001114634
NM_001114635
NM_002655
PLAG1


pleiomorphic adenoma gene 1


chr1_+_163038934 1.576 NM_001113381
RGS4
regulator of G-protein signaling 4
chr12_+_32654976 1.566 NM_139241
FGD4
FYVE, RhoGEF and PH domain containing 4
chr11_-_27681195 1.560 NM_001143816
NM_170735
BDNF

brain-derived neurotrophic factor

chr3_+_156394452 1.531 NM_001184718
TIPARP
TCDD-inducible poly(ADP-ribose) polymerase
chr4_-_90759446 1.503 NM_001146055
SNCA
synuclein, alpha (non A4 component of amyloid precursor)
chr1_+_185703470 1.497 NM_031935
HMCN1
hemicentin 1
chr7_-_27213873 1.483 NM_018951
HOXA10
homeobox A10
chr18_-_22932109 1.483 NM_015461
ZNF521
zinc finger protein 521
chr6_+_15246299 1.477 NM_004973
JARID2
jumonji, AT rich interactive domain 2
chr2_+_120517206 1.433 NM_002830
PTPN4
protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte)
chr2_+_109237679 1.431 NM_001193484
LIMS1
LIM and senescent cell antigen-like domains 1
chr7_+_111846642 1.429 NM_021994
ZNF277
zinc finger protein 277
chr6_-_76203256 1.413 NM_015687
FILIP1
filamin A interacting protein 1
chr5_-_88119604 1.390 NM_001193348
NM_001193349
MEF2C

myocyte enhancer factor 2C

chr16_-_71318761 1.368 FTSJD1
FtsJ methyltransferase domain containing 1
chr6_+_17600504 1.352 NM_016255
FAM8A1
family with sequence similarity 8, member A1
chr9_-_124989755 1.317 NM_001242334
LHX6
LIM homeobox 6
chr2_+_66662516 1.317 NM_002398
MEIS1
Meis homeobox 1
chr3_+_25469833 1.298 NM_000965
RARB
retinoic acid receptor, beta
chr1_+_15272414 1.298 NM_001017999
KAZN
kazrin, periplakin interacting protein
chr7_+_111846736 1.283 ZNF277
zinc finger protein 277
chr6_+_148664124 1.277 SASH1
SAM and SH3 domain containing 1
chr14_+_77228132 1.242 NM_014909
VASH1
vasohibin 1
chrX_-_33229428 1.237 NM_004006
DMD
dystrophin
chr5_+_68800003 1.233 NM_001205255
OCLN
occludin
chrX_-_99891690 1.232 NM_003270
TSPAN6
tetraspanin 6
chr1_+_153232178 1.215 NM_000427
LOR
loricrin
chr5_-_111312522 1.213 NM_001142474
NM_001142475
C5orf13

chromosome 5 open reading frame 13

chr6_+_132891460 1.212 NM_175067
TAAR6
trace amine associated receptor 6
chr11_+_60552820 1.203 NM_206893
MS4A10
membrane-spanning 4-domains, subfamily A, member 10
chrX_-_62974341 1.201 ARHGEF9
Cdc42 guanine nucleotide exchange factor (GEF) 9
chrX_-_10588458 1.194 NM_000381
NM_033289
MID1

midline 1 (Opitz/BBB syndrome)

chr4_+_175204827 1.180 NM_001040157
CEP44
centrosomal protein 44kDa
chr6_+_56911310 1.180 NM_020931
KIAA1586
KIAA1586
chr2_+_109204904 1.179 NM_001193488
LIMS1
LIM and senescent cell antigen-like domains 1
chr1_-_53018630 1.179 ZCCHC11
zinc finger, CCHC domain containing 11
chr1_+_212475147 1.174 NM_001199756
PPP2R5A
protein phosphatase 2, regulatory subunit B', alpha
chr1_+_87794548 1.161 LMO4
LIM domain only 4
chr17_-_1248346 1.157 PAFAH1B1
platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)
chr2_+_66662692 1.149 MEIS1
Meis homeobox 1
chr19_+_45971249 1.149 NM_001114171
NM_006732
FOSB

FBJ murine osteosarcoma viral oncogene homolog B

chr11_+_46299585 1.148 CREB3L1
cAMP responsive element binding protein 3-like 1
chr2_-_133427624 1.147 LYPD1
LY6/PLAUR domain containing 1
chr1_+_150336989 1.134 NM_015203
RPRD2
regulation of nuclear pre-mRNA domain containing 2
chr8_-_74659082 1.133 NM_001164380
NM_001164381
NM_001164382
NM_001164383
NM_001164385
NM_014393
STAU2





staufen, RNA binding protein, homolog 2 (Drosophila)





chr20_-_45976626 1.132 ZMYND8
zinc finger, MYND-type containing 8
chr12_-_29937691 1.127 NM_175861
TMTC1
transmembrane and tetratricopeptide repeat containing 1
chr2_+_110656008 1.114 NM_001205288
NM_033514
LIMS3-LOC440895
LIMS3L
LIMS3
LIMS3-LOC440895 readthrough
LIM and senescent cell antigen-like domains 3-like
LIM and senescent cell antigen-like domains 3
chr10_+_94594469 1.114 NM_001013848
EXOC6
exocyst complex component 6
chr10_-_113933517 1.111 GPAM
glycerol-3-phosphate acyltransferase, mitochondrial
chr12_-_86229981 1.108 RASSF9
Ras association (RalGDS/AF-6) domain family (N-terminal) member 9
chrX_-_50557019 1.106 NM_020717
SHROOM4
shroom family member 4
chr5_-_111093251 1.106 NM_001142479
NM_001142480
NM_001142478
C5orf13


chromosome 5 open reading frame 13


chr20_-_29993955 1.095 NM_001011878
DEFB121
defensin, beta 121
chr12_-_86230158 1.094 NM_005447
RASSF9
Ras association (RalGDS/AF-6) domain family (N-terminal) member 9
chrX_-_117107700 1.091 NM_033495
NM_001168300
KLHL13

kelch-like 13 (Drosophila)

chr1_+_33722158 1.083 NM_152493
ZNF362
zinc finger protein 362
chr4_+_170581212 1.080 NM_001243374
CLCN3
chloride channel 3
chr15_+_39542884 1.071 NM_207445
C15orf54
chromosome 15 open reading frame 54
chr9_-_86082656 1.068 NM_001244960
FRMD3
FERM domain containing 3
chr9_-_126030854 1.064 NM_001171137
STRBP
spermatid perinuclear RNA binding protein
chrX_-_135749436 1.063 ARHGEF6
Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
chr11_+_9596233 1.063 NM_001143976
WEE1
WEE1 homolog (S. pombe)
chr9_-_126030792 1.056 NM_018387
STRBP
spermatid perinuclear RNA binding protein
chr1_+_84630374 1.053 PRKACB
protein kinase, cAMP-dependent, catalytic, beta
chr2_-_111230651 1.049 NM_001205288
NM_033514
LIMS3-LOC440895
LIMS3L
LIMS3
LIMS3-LOC440895 readthrough
LIM and senescent cell antigen-like domains 3-like
LIM and senescent cell antigen-like domains 3
chr14_-_23904849 1.047 NM_000257
MYH7
myosin, heavy chain 7, cardiac muscle, beta
chr13_+_78315294 1.047 NM_001242869
NM_001242870
NM_001242871
NM_144595
SLAIN1



SLAIN motif family, member 1



chr4_-_90758126 1.033 NM_001146054
NM_007308
NM_000345
SNCA


synuclein, alpha (non A4 component of amyloid precursor)


chr10_-_14646237 1.030 FAM107B
family with sequence similarity 107, member B
chr20_+_306205 1.022 NM_006943
SOX12
SRY (sex determining region Y)-box 12
chr2_+_62934030 1.019 NM_001142614
EHBP1
EH domain binding protein 1
chr13_-_33760215 1.014 NM_001243466
NM_178007
STARD13

StAR-related lipid transfer (START) domain containing 13

chr5_+_40841296 1.012 NM_032587
CARD6
caspase recruitment domain family, member 6
chr14_-_77494621 1.009 IRF2BPL
interferon regulatory factor 2 binding protein-like
chr14_-_77494974 1.004 NM_024496
IRF2BPL
interferon regulatory factor 2 binding protein-like
chr17_+_67498391 1.003 MAP2K6
mitogen-activated protein kinase kinase 6
chr1_+_84864214 0.998 NM_021233
DNASE2B
deoxyribonuclease II beta
chr9_+_15422630 0.998 NM_001039697
SNAPC3
small nuclear RNA activating complex, polypeptide 3, 50kDa
chr4_-_174450529 0.998 HAND2
heart and neural crest derivatives expressed 2
chr3_-_64211111 0.995 NM_198859
PRICKLE2
prickle homolog 2 (Drosophila)
chr17_-_34122547 0.987 NM_001032278
NM_024302
MMP28

matrix metallopeptidase 28

chr6_+_87969619 0.979 ZNF292
zinc finger protein 292
chr6_-_139695784 0.976 NM_006079
CITED2
Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
chr10_-_116444112 0.966 ABLIM1
actin binding LIM protein 1
chr4_+_124317884 0.965 NM_199327
SPRY1
sprouty homolog 1, antagonist of FGF signaling (Drosophila)
chr15_-_56388662 0.964 RFX7
regulatory factor X, 7
chr5_-_111092918 0.963 NM_004772
C5orf13
chromosome 5 open reading frame 13
chr13_+_50025687 0.962 NM_001160308
SETDB2
SET domain, bifurcated 2
chrX_-_106959597 0.962 NM_001015881
TSC22D3
TSC22 domain family, member 3
chr3_-_47621729 0.951 NM_001206942
NM_001206945
CSPG5

chondroitin sulfate proteoglycan 5 (neuroglycan C)

chr12_-_31743822 0.944 NM_144973
DENND5B
DENN/MADD domain containing 5B
chrX_-_100872926 0.936 NM_001009584
NM_001184768
NM_019007
ARMCX6


armadillo repeat containing, X-linked 6


chr5_-_111091947 0.934 NM_001142483
C5orf13
chromosome 5 open reading frame 13
chr8_+_74207093 0.933 RDH10
retinol dehydrogenase 10 (all-trans)
chr2_-_70475563 0.931 NM_022037
NM_022173
TIA1

TIA1 cytotoxic granule-associated RNA binding protein

chr9_-_125941304 0.929 STRBP
spermatid perinuclear RNA binding protein
chr15_-_49338496 0.925 NM_001193489
NM_014701
SECISBP2L

SECIS binding protein 2-like

chr12_+_109490339 0.923 NM_032663
USP30
ubiquitin specific peptidase 30
chr6_-_139695739 0.920 CITED2
Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
chr17_-_46671322 0.914 HOXB5
homeobox B5
chr14_-_89883306 0.911 NM_005197
FOXN3
forkhead box N3
chr12_-_102874340 0.909 IGF1
insulin-like growth factor 1 (somatomedin C)
chr20_+_44462395 0.901 NM_001042632
NM_001042633
NM_033421
NM_152897
SNX21



sorting nexin family member 21



chr2_+_109271267 0.898 NM_001193485
LIMS1
LIM and senescent cell antigen-like domains 1
chr7_+_80267922 0.889 CD36
CD36 molecule (thrombospondin receptor)
chr9_-_97402530 0.882 NM_001127628
FBP1
fructose-1,6-bisphosphatase 1
chr5_+_36876899 0.873 NIPBL
Nipped-B homolog (Drosophila)
chr9_-_75567915 0.868 ALDH1A1
aldehyde dehydrogenase 1 family, member A1
chr10_-_14646407 0.867 FAM107B
family with sequence similarity 107, member B
chr5_-_111093030 0.865 NM_001142482
NM_001142481
C5orf13

chromosome 5 open reading frame 13

chr3_-_56698073 0.863 NM_015224
FAM208A
family with sequence similarity 208, member A
chr6_-_139695349 0.862 NM_001168389
NM_001168388
CITED2

Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2

chr17_+_30814552 0.850 CDK5R1
cyclin-dependent kinase 5, regulatory subunit 1 (p35)
chr7_+_80267782 0.845 NM_000072
NM_001001548
CD36

CD36 molecule (thrombospondin receptor)

chrX_-_134429958 0.844 NM_001185063
NM_007131
ZNF75D

zinc finger protein 75D

chr4_+_175205044 0.841 NM_001145314
CEP44
centrosomal protein 44kDa
chr2_-_238499317 0.825 RAB17
RAB17, member RAS oncogene family
chr13_+_33160537 0.825 NM_015032
PDS5B
PDS5, regulator of cohesion maintenance, homolog B (S. cerevisiae)
chr5_+_42565963 0.824 NM_001242460
NM_001242461
NM_001242462
GHR


growth hormone receptor


chr10_+_102759607 0.817 LZTS2
leucine zipper, putative tumor suppressor 2
chr10_-_105110823 0.814 PCGF6
polycomb group ring finger 6
chr12_+_20724797 0.811 NM_001244683
PDE3A
phosphodiesterase 3A, cGMP-inhibited
chr5_-_154230157 0.808 C5orf4
chromosome 5 open reading frame 4
chr10_-_105110844 0.803 PCGF6
polycomb group ring finger 6
chr15_+_80364902 0.798 NM_001242915
NM_001242916
ZFAND6

zinc finger, AN1-type domain 6


Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.34 8.41e-04 GO:2000112 regulation of cellular macromolecule biosynthetic process
1.32 3.36e-03 GO:0010556 regulation of macromolecule biosynthetic process
1.30 5.20e-03 GO:0031326 regulation of cellular biosynthetic process
1.29 6.37e-03 GO:0009889 regulation of biosynthetic process
1.28 3.25e-02 GO:0010468 regulation of gene expression
1.30 4.02e-02 GO:0006355 regulation of transcription, DNA-dependent
2.01 4.44e-02 GO:0030036 actin cytoskeleton organization

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.20 3.48e-05 GO:0005634 nucleus
1.32 1.69e-03 GO:0044428 nuclear part

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.31 9.21e-06 GO:0003676 nucleic acid binding
1.37 2.52e-05 GO:0003677 DNA binding
1.07 2.10e-02 GO:0005488 binding
1.26 4.53e-02 GO:0046914 transition metal ion binding