Motif ID: SRF.p3

Z-value: 1.511


Transcription factors associated with SRF.p3:

Gene SymbolEntrez IDGene Name
SRF 6722 serum response factor (c-fos serum response element-binding transcription factor)

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.p-valuePlot
SRFchr6_+_431391900.116.0e-01Click!


Activity profile for motif SRF.p3.

activity profile for motif SRF.p3


Sorted Z-values histogram for motif SRF.p3

Sorted Z-values for motif SRF.p3



Network of associatons between targets according to the STRING database.



First level regulatory network of SRF.p3

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr5_+_137801166 38.093 EGR1
early growth response 1
chr5_+_137801178 23.711 NM_001964
EGR1
early growth response 1
chr10_-_64576123 11.434 NM_000399
NM_001136177
NM_001136179
EGR2


early growth response 2


chr10_-_64576074 10.962 EGR2
early growth response 2
chr8_-_22550708 4.710 NM_004430
EGR3
early growth response 3
chr19_+_45971249 4.533 NM_001114171
NM_006732
FOSB

FBJ murine osteosarcoma viral oncogene homolog B

chr10_+_112257624 3.811 NM_004419
DUSP5
dual specificity phosphatase 5
chr12_+_52445185 2.593 NM_002135
NM_173157
NR4A1

nuclear receptor subfamily 4, group A, member 1

chr20_+_35169876 2.503 NM_006097
NM_181526
MYL9

myosin, light chain 9, regulatory

chr14_+_75745480 2.247 NM_005252
FOS
FBJ murine osteosarcoma viral oncogene homolog
chr20_+_35169897 2.226 MYL9
myosin, light chain 9, regulatory
chr19_+_49376488 2.132 PPP1R15A
protein phosphatase 1, regulatory subunit 15A
chr11_-_65667809 2.001 FOSL1
FOS-like antigen 1
chr11_-_65667858 1.877 FOSL1
FOS-like antigen 1
chr1_+_181057835 1.874 IER5
immediate early response 5
chr11_-_65667860 1.857 NM_005438
FOSL1
FOS-like antigen 1
chr2_-_73520448 1.758 NM_001965
EGR4
early growth response 4
chr4_+_81118639 1.693 NM_001099403
PRDM8
PR domain containing 8
chr5_-_33892292 1.647 ADAMTS12
ADAM metallopeptidase with thrombospondin type 1 motif, 12
chr6_-_29527701 1.560 NM_006398
UBD
ubiquitin D
chr7_+_143078399 1.364 ZYX
zyxin
chr10_-_90712510 1.354 NM_001613
ACTA2
actin, alpha 2, smooth muscle, aorta
chr5_-_33891967 1.343 NM_030955
ADAMTS12
ADAM metallopeptidase with thrombospondin type 1 motif, 12
chr7_+_143078358 1.287 NM_001010972
NM_003461
ZYX

zyxin

chr7_+_143078444 1.172 ZYX
zyxin
chr7_+_143078447 1.171 ZYX
zyxin
chr7_+_143078395 1.162 ZYX
zyxin
chr19_+_13134782 1.130 NFIX
nuclear factor I/X (CCAAT-binding transcription factor)
chr11_-_30605748 1.130 MPPED2
metallophosphoesterase domain containing 2
chr12_-_11548485 1.084 NM_006248
PRB1
PRB2
proline-rich protein BstNI subfamily 1
proline-rich protein BstNI subfamily 2
chr6_-_29527477 1.075 UBD
ubiquitin D
chr3_-_123339178 1.031 MYLK
myosin light chain kinase
chr5_-_58295758 1.017 NM_001197223
PDE4D
phosphodiesterase 4D, cAMP-specific
chr22_+_31480981 1.015 NM_001207018
SMTN
smoothelin
chr7_+_143078457 0.980 ZYX
zyxin
chr14_-_74226890 0.964 NM_194278
C14orf43
chromosome 14 open reading frame 43
chr3_-_123339423 0.956 NM_053031
NM_053032
MYLK

myosin light chain kinase

chr19_+_13135368 0.903 NFIX
nuclear factor I/X (CCAAT-binding transcription factor)
chr11_-_75921785 0.900 WNT11
wingless-type MMTV integration site family, member 11
chr1_-_229569839 0.873 NM_001100
ACTA1
actin, alpha 1, skeletal muscle
chr4_+_89299874 0.852 NM_001165136
NM_017912
HERC6

hect domain and RLD 6

chr1_-_2461683 0.832 NM_001010926
HES5
hairy and enhancer of split 5 (Drosophila)
chr2_-_69180011 0.811 NM_182536
GKN2
gastrokine 2
chr6_-_88411948 0.776 AKIRIN2
akirin 2
chr15_+_45406518 0.726 NM_207581
DUOXA2
dual oxidase maturation factor 2
chr2_-_31030271 0.713 NM_144575
CAPN13
calpain 13
chr16_-_69385656 0.704 NM_144676
TMED6
transmembrane emp24 protein transport domain containing 6
chr17_-_34207308 0.680 NM_002985
CCL5
chemokine (C-C motif) ligand 5
chr7_+_143078608 0.675 ZYX
zyxin
chr6_-_29644930 0.672 NM_001109809
ZFP57
zinc finger protein 57 homolog (mouse)
chr12_-_11508509 0.655 NM_005039
NM_199353
NM_199354
PRB1


proline-rich protein BstNI subfamily 1


chr12_-_24103842 0.642 SOX5
SRY (sex determining region Y)-box 5
chr15_-_65360297 0.634 NM_016563
RASL12
RAS-like, family 12
chr14_-_74226634 0.622 C14orf43
chromosome 14 open reading frame 43
chr1_+_50574601 0.592 ELAVL4
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)
chr2_+_139259476 0.560


chr5_-_179050635 0.538 HNRNPH1
heterogeneous nuclear ribonucleoprotein H1 (H)
chr6_-_109775423 0.528 MICAL1
microtubule associated monoxygenase, calponin and LIM domain containing 1
chr4_+_24797084 0.521 NM_003102
SOD3
superoxide dismutase 3, extracellular
chr19_-_47975244 0.520 NM_015063
SLC8A2
solute carrier family 8 (sodium/calcium exchanger), member 2
chr12_+_54426831 0.518 NM_018953
HOXC5
homeobox C5
chr12_-_11463353 0.514 NM_002723
PRB4
proline-rich protein BstNI subfamily 4
chr1_+_167599329 0.508 NM_052862
RCSD1
RCSD domain containing 1
chr16_+_70657894 0.493 NM_001172772
IL34
interleukin 34
chr6_-_88411872 0.492 AKIRIN2
akirin 2
chr11_+_117070039 0.489 NM_001001522
NM_003186
TAGLN

transgelin

chr2_-_96811138 0.485 NM_004418
DUSP2
dual specificity phosphatase 2
chr9_-_98269686 0.484 NM_001083606
PTCH1
patched 1
chr17_-_4890664 0.479 NM_001171167
NM_001171168
CAMTA2

calmodulin binding transcription activator 2

chr16_+_56966025 0.476 HERPUD1
homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
chr2_-_106015423 0.475 NM_001039492
NM_001450
NM_201555
FHL2


four and a half LIM domains 2


chr17_+_32612686 0.455 NM_002986
CCL11
chemokine (C-C motif) ligand 11
chr3_-_156878481 0.438 NM_020307
CCNL1
cyclin L1
chr6_-_88411649 0.434 AKIRIN2
akirin 2
chr20_-_62680880 0.428 NM_018419
SOX18
SRY (sex determining region Y)-box 18
chr11_+_62432778 0.425 NM_001043229
METTL12
methyltransferase like 12
chr7_+_94285676 0.425 NM_001172437
NM_001172438
PEG10

paternally expressed 10

chr17_-_4890920 0.424 NM_001171166
NM_015099
CAMTA2

calmodulin binding transcription activator 2

chr12_+_6881669 0.417 NM_002286
LAG3
lymphocyte-activation gene 3
chr7_+_94285736 0.417 PEG10
paternally expressed 10
chr7_-_121944485 0.414 NM_001024613
NM_001160264
FEZF1

FEZ family zinc finger 1

chr7_+_114055048 0.405 NM_001172766
NM_014491
NM_148898
NM_148900
FOXP2



forkhead box P2



chr10_+_6186758 0.395 NM_001145443
PFKFB3
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
chr17_-_10560625 0.390 NM_002470
MYH3
myosin, heavy chain 3, skeletal muscle, embryonic
chrX_-_11284094 0.382 NM_013423
ARHGAP6
Rho GTPase activating protein 6
chr19_-_36247917 0.376 NM_144617
HSPB6
heat shock protein, alpha-crystallin-related, B6
chr7_-_44180911 0.371 NM_021223
MYL7
myosin, light chain 7, regulatory
chr5_-_179050675 0.371 NM_005520
HNRNPH1
heterogeneous nuclear ribonucleoprotein H1 (H)
chr2_-_128432642 0.370 NM_001136037
NM_001161403
LIMS2

LIM and senescent cell antigen-like domains 2

chr11_+_59807747 0.370 NM_173801
PLAC1L
placenta-specific 1-like
chr5_+_140749830 0.369 NM_018924
NM_032097
PCDHGB3

protocadherin gamma subfamily B, 3

chr15_-_45670624 0.367 GATM
glycine amidinotransferase (L-arginine:glycine amidinotransferase)
chr4_-_76957139 0.367 NM_005409
CXCL11
chemokine (C-X-C motif) ligand 11
chr3_+_143690639 0.362 NM_173552
C3orf58
chromosome 3 open reading frame 58
chr9_+_139249251 0.353 NM_001200003
GPSM1
G-protein signaling modulator 1
chr16_-_67977956 0.345 NM_000229
LCAT
lecithin-cholesterol acyltransferase
chr2_-_242212244 0.344 NM_001243900
NM_203346
HDLBP

high density lipoprotein binding protein

chr16_-_11375094 0.343 NM_002761
PRM1
protamine 1
chr10_+_6186903 0.342 PFKFB3
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
chr2_+_219283809 0.341 NM_007127
VIL1
villin 1
chr12_+_2162703 0.329 CACNA1C
calcium channel, voltage-dependent, L type, alpha 1C subunit
chr2_-_31805968 0.327 NM_000348
SRD5A2
steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2)
chr12_+_26348488 0.323 NM_005086
SSPN
sarcospan (Kras oncogene-associated gene)
chr15_+_33603162 0.321 NM_001036
NM_001243996
RYR3

ryanodine receptor 3

chrX_+_99839789 0.320 NM_022144
TNMD
tenomodulin
chr3_-_9834065 0.300 TADA3
transcriptional adaptor 3
chr14_+_78227172 0.300 NM_001173978
NM_174943
C14orf178

chromosome 14 open reading frame 178

chr9_-_134585107 0.293 NM_198679
RAPGEF1
Rap guanine nucleotide exchange factor (GEF) 1
chr7_+_114055171 0.288 FOXP2
forkhead box P2
chr12_-_55028624 0.288 NM_033277
LACRT
lacritin
chrX_-_153602928 0.287 FLNA
filamin A, alpha
chr6_-_26108320 0.285 NM_005323
HIST1H1T
histone cluster 1, H1t
chr22_-_36784055 0.285 NM_002473
MYH9
myosin, heavy chain 9, non-muscle
chr7_-_27183225 0.273 NM_019102
HOXA5
homeobox A5
chr17_+_41132581 0.271 NM_173079
RUNDC1
RUN domain containing 1
chr6_+_167525294 0.261 NM_004367
CCR6
chemokine (C-C motif) receptor 6
chr10_+_88428167 0.259 NM_001171610
LDB3
LIM domain binding 3
chr21_-_28217272 0.258 ADAMTS1
ADAM metallopeptidase with thrombospondin type 1 motif, 1
chr17_-_79792867 0.254 PPP1R27
protein phosphatase 1, regulatory subunit 27
chr2_-_161056573 0.252 NM_000888
ITGB6
integrin, beta 6
chr20_+_207898 0.246 NM_080831
DEFB129
defensin, beta 129
chr10_-_131762374 0.242 EBF3
early B-cell factor 3
chr12_+_4382882 0.236 NM_001759
CCND2
cyclin D2
chr17_-_66287256 0.226 NM_001174166
NM_004694
SLC16A6

solute carrier family 16, member 6 (monocarboxylic acid transporter 7)

chr9_-_98269480 0.226 NM_001083607
PTCH1
patched 1
chr17_+_33474835 0.225 NM_001033576
NM_173167
UNC45B

unc-45 homolog B (C. elegans)

chr19_-_47975074 0.224 SLC8A2
solute carrier family 8 (sodium/calcium exchanger), member 2
chr19_+_56153417 0.223 NM_016202
NM_001163423
ZNF580

zinc finger protein 580

chr3_-_78666943 0.222 ROBO1
roundabout, axon guidance receptor, homolog 1 (Drosophila)
chr17_-_72527512 0.219 CD300LB
CD300 molecule-like family member b
chrX_+_82763268 0.219 NM_000307
POU3F4
POU class 3 homeobox 4
chr17_+_41132587 0.216 RUNDC1
RUN domain containing 1
chr1_+_11994710 0.216 NM_000302
PLOD1
procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1
chr10_+_6186878 0.216 PFKFB3
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
chr4_-_185747051 0.204 ACSL1
acyl-CoA synthetase long-chain family member 1
chr11_+_18416111 0.200 LDHA
lactate dehydrogenase A
chr2_-_225378320 0.199 CUL3
cullin 3
chr2_-_220252569 0.198 DNPEP
aspartyl aminopeptidase
chr6_-_88411984 0.197 NM_018064
AKIRIN2
akirin 2
chr17_-_37350051 0.197 CACNB1
calcium channel, voltage-dependent, beta 1 subunit
chr17_-_72527592 0.196 NM_174892
CD300LB
CD300 molecule-like family member b
chr11_+_18416106 0.182 LDHA
lactate dehydrogenase A
chr1_-_11907741 0.174 NM_006172
NPPA
natriuretic peptide A
chr11_-_16430425 0.172 NM_001145811
SOX6
SRY (sex determining region Y)-box 6
chr1_-_150552005 0.166 MCL1
myeloid cell leukemia sequence 1 (BCL2-related)
chr9_+_18474078 0.165 NM_001040272
NM_052866
ADAMTSL1

ADAMTS-like 1

chr4_+_6695565 0.163 NM_005980
S100P
S100 calcium binding protein P
chr9_+_36136710 0.163 NM_022343
GLIPR2
GLI pathogenesis-related 2
chr5_-_131879172 0.163 NM_000879
IL5
interleukin 5 (colony-stimulating factor, eosinophil)
chr17_-_73505914 0.159 NM_001142643
CASKIN2
CASK interacting protein 2
chr22_+_38004454 0.159 NM_001001560
NM_001001561
NM_001172687
NM_013365
GGA1



golgi-associated, gamma adaptin ear containing, ARF binding protein 1



chr2_-_151344145 0.159 NM_005168
RND3
Rho family GTPase 3
chr2_-_220252627 0.157 NM_012100
DNPEP
aspartyl aminopeptidase
chr5_-_124080773 0.155 NM_020747
ZNF608
zinc finger protein 608
chr1_+_151512760 0.154 NM_001126337
NM_020127
TUFT1

tuftelin 1

chr17_-_79479831 0.151 NM_001199954
NM_001614
ACTG1

actin, gamma 1

chr3_-_185641596 0.144 TRA2B
transformer 2 beta homolog (Drosophila)
chr3_-_9834357 0.143 NM_006354
NM_133480
TADA3

transcriptional adaptor 3

chr3_-_12941547 0.142 IQSEC1
IQ motif and Sec7 domain 1
chr10_-_29923900 0.140 NM_021738
SVIL
supervillin
chr1_-_120935893 0.138 FCGR1B
Fc fragment of IgG, high affinity Ib, receptor (CD64)
chr6_+_43139190 0.135 SRF
serum response factor (c-fos serum response element-binding transcription factor)
chr21_-_35987144 0.133 NM_004414
RCAN1
regulator of calcineurin 1
chr7_-_80548322 0.130 SEMA3C
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
chrX_-_153602998 0.130 NM_001110556
NM_001456
FLNA

filamin A, alpha

chr9_+_116356199 0.128 NM_144489
RGS3
regulator of G-protein signaling 3
chr14_-_106209380 0.126 IGHG1
immunoglobulin heavy constant gamma 1 (G1m marker)
chr22_+_38004676 0.124 GGA1
golgi-associated, gamma adaptin ear containing, ARF binding protein 1
chr17_+_3379295 0.124 NM_000049
ASPA
aspartoacylase
chr4_+_86699858 0.123 ARHGAP24
Rho GTPase activating protein 24
chr10_+_88428263 0.121 NM_001080116
NM_001080114
NM_001080115
NM_001171611
NM_007078
LDB3




LIM domain binding 3




chr7_-_80548666 0.121 NM_006379
SEMA3C
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
chr20_+_2276612 0.120 NM_003245
TGM3
transglutaminase 3 (E polypeptide, protein-glutamine-gamma-glutamyltransferase)
chr1_+_11994778 0.119 PLOD1
procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1
chr19_-_49926598 0.117 NM_178449
PTH2
parathyroid hormone 2
chr11_+_75273245 0.116 SERPINH1
serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
chr5_-_169816637 0.114 NM_004137
KCNMB1
potassium large conductance calcium-activated channel, subfamily M, beta member 1
chr15_-_45406345 0.112 NM_014080
DUOX2
dual oxidase 2
chr11_-_84634219 0.111 DLG2
discs, large homolog 2 (Drosophila)
chr11_-_19223516 0.111 NM_001127656
NM_003476
CSRP3

cysteine and glycine-rich protein 3 (cardiac LIM protein)

chr2_+_219264477 0.109 NM_021198
NM_182642
CTDSP1

CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1

chr16_+_31483066 0.109 NM_001042454
NM_001164719
TGFB1I1

transforming growth factor beta 1 induced transcript 1

chr8_-_41504873 0.108 NM_152568
NKX6-3
NK6 homeobox 3
chr14_-_106111114 0.107 IGHG2
immunoglobulin heavy constant gamma 2 (G2m marker)
chr7_+_94285620 0.107 NM_001040152
NM_001184961
NM_001184962
NM_015068
PEG10



paternally expressed 10



chr6_-_36953942 0.106 MTCH1
mitochondrial carrier 1
chr3_+_67048726 0.106 NM_032505
KBTBD8
kelch repeat and BTB (POZ) domain containing 8
chr12_+_62654120 0.103 NM_001252078
NM_001252079
NM_006313
USP15


ubiquitin specific peptidase 15


chr17_-_79479780 0.103 ACTG1
actin, gamma 1
chr7_-_75443026 0.101 NM_002991
CCL24
chemokine (C-C motif) ligand 24
chr3_+_187930720 0.101 NM_005578
LPP
LIM domain containing preferred translocation partner in lipoma
chr10_-_16859389 0.101 RSU1
Ras suppressor protein 1
chr16_+_22103861 0.100 NM_173615
VWA3A
von Willebrand factor A domain containing 3A
chr4_-_140060601 0.100 NM_201999
ELF2
E74-like factor 2 (ets domain transcription factor)
chr12_+_50497790 0.099 NM_005276
GPD1
glycerol-3-phosphate dehydrogenase 1 (soluble)
chr20_+_33146500 0.096 NM_032514
MAP1LC3A
microtubule-associated protein 1 light chain 3 alpha
chr7_-_5570188 0.095 NM_001101
ACTB
actin, beta
chrX_-_32430370 0.095 NM_004011
NM_004012
DMD

dystrophin

chr1_+_6105980 0.093 NM_001199862
KCNAB2
potassium voltage-gated channel, shaker-related subfamily, beta member 2
chr11_+_63580922 0.092 NM_138471
C11orf84
chromosome 11 open reading frame 84

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.90 4.38e-07 GO:0032502 developmental process
1.94 1.00e-06 GO:0007275 multicellular organismal development
1.98 1.61e-06 GO:0048856 anatomical structure development
1.67 2.67e-06 GO:0032501 multicellular organismal process
6.61 9.90e-06 GO:0003012 muscle system process
13.37 2.12e-05 GO:0030048 actin filament-based movement
1.97 2.53e-05 GO:0048731 system development
6.71 2.56e-05 GO:0006936 muscle contraction
13.95 6.14e-04 GO:0070252 actin-mediated cell contraction
2.11 7.17e-04 GO:0048513 organ development
5.35 1.13e-03 GO:0007517 muscle organ development
4.39 2.07e-03 GO:0061061 muscle structure development
1.99 2.73e-03 GO:0030154 cell differentiation
4.21 3.45e-03 GO:0030029 actin filament-based process
1.94 5.83e-03 GO:0048869 cellular developmental process
12.28 8.83e-03 GO:0030049 muscle filament sliding
12.28 8.83e-03 GO:0033275 actin-myosin filament sliding
17.22 9.06e-03 GO:0043542 endothelial cell migration
1.86 1.03e-02 GO:0042221 response to chemical stimulus
2.54 1.42e-02 GO:0009888 tissue development
25.25 1.45e-02 GO:0043534 blood vessel endothelial cell migration
3.81 4.57e-02 GO:0010035 response to inorganic substance

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
5.04 1.56e-06 GO:0015629 actin cytoskeleton
8.01 1.62e-06 GO:0043292 contractile fiber
8.05 5.78e-06 GO:0044449 contractile fiber part
7.84 7.76e-06 GO:0030016 myofibril
15.15 4.03e-04 GO:0032432 actin filament bundle
2.11 9.13e-04 GO:0005856 cytoskeleton
13.53 5.24e-03 GO:0001725 stress fiber
6.19 8.28e-03 GO:0030017 sarcomere
6.12 8.91e-03 GO:0005925 focal adhesion
11.48 1.20e-02 GO:0042641 actomyosin
5.83 1.27e-02 GO:0005924 cell-substrate adherens junction
1.79 1.40e-02 GO:0005576 extracellular region
5.61 1.65e-02 GO:0030055 cell-substrate junction
4.58 2.94e-02 GO:0005912 adherens junction

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.38 6.27e-04 GO:0005515 protein binding
3.62 4.06e-03 GO:0003779 actin binding
18.94 9.84e-03 GO:0000146 microfilament motor activity