Motif ID: STAT2,4,6.p2

Z-value: 2.312


Transcription factors associated with STAT2,4,6.p2:

Gene SymbolEntrez IDGene Name
STAT2 6773 signal transducer and activator of transcription 2, 113kDa
STAT4 6775 signal transducer and activator of transcription 4
STAT6 6778 signal transducer and activator of transcription 6, interleukin-4 induced

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.p-valuePlot
STAT6chr12_-_575051760.912.0e-10Click!
STAT4chr2_-_192015934,
chr2_-_192016293,
chr2_-_192015706
-0.855.8e-08Click!
STAT2chr12_-_567538560.116.0e-01Click!


Activity profile for motif STAT2,4,6.p2.

activity profile for motif STAT2,4,6.p2


Sorted Z-values histogram for motif STAT2,4,6.p2

Sorted Z-values for motif STAT2,4,6.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of STAT2,4,6.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr19_+_10381763 25.604 ICAM1
intercellular adhesion molecule 1
chr19_+_10381516 21.068 NM_000201
ICAM1
intercellular adhesion molecule 1
chr14_-_51134862 8.220 SAV1
salvador homolog 1 (Drosophila)
chr14_-_51135021 7.566 NM_021818
SAV1
salvador homolog 1 (Drosophila)
chr14_-_51135041 7.412 SAV1
salvador homolog 1 (Drosophila)
chr3_-_71294229 7.399 NM_001244814
FOXP1
forkhead box P1
chr6_-_137113721 7.172 MAP3K5
mitogen-activated protein kinase kinase kinase 5
chr6_-_137113529 7.162 MAP3K5
mitogen-activated protein kinase kinase kinase 5
chr6_-_137113602 7.106 MAP3K5
mitogen-activated protein kinase kinase kinase 5
chr4_-_185395616 6.870 NM_002199
IRF2
interferon regulatory factor 2
chrX_-_154563735 6.812 NM_001289
CLIC2
chloride intracellular channel 2
chr4_+_74606222 6.622 NM_000584
IL8
interleukin 8
chr6_+_32821924 6.527 NM_002800
PSMB9
proteasome (prosome, macropain) subunit, beta type, 9 (large multifunctional peptidase 2)
chr19_+_4229494 6.476 NM_005755
EBI3
Epstein-Barr virus induced 3
chr6_-_32821592 6.390 TAP1
transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
chr6_-_32821743 6.336 NM_000593
TAP1
transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
chr6_-_32821412 6.166 TAP1
transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
chr1_-_169703178 6.097 NM_000450
SELE
selectin E
chr3_+_122399665 6.065 NM_017554
PARP14
poly (ADP-ribose) polymerase family, member 14
chr6_-_137113624 6.051 NM_005923
MAP3K5
mitogen-activated protein kinase kinase kinase 5
chr21_+_26934440 6.051 MIR155HG
MIR155 host gene (non-protein coding)
chr1_-_173174611 6.050 TNFSF4
tumor necrosis factor (ligand) superfamily, member 4
chr15_+_67358161 5.668 SMAD3
SMAD family member 3
chr6_-_29527701 5.610 NM_006398
UBD
ubiquitin D
chr5_+_131409484 5.382 NM_000758
CSF2
colony stimulating factor 2 (granulocyte-macrophage)
chr1_-_41328002 5.165 NM_133467
CITED4
Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 4
chr21_+_43919741 5.100 NM_018964
SLC37A1
solute carrier family 37 (glycerol-3-phosphate transporter), member 1
chr1_-_41328019 5.040 CITED4
Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 4
chr15_+_67358194 5.014 NM_005902
SMAD3
SMAD family member 3
chr11_+_71710971 4.934 NM_001145055
IL18BP
interleukin 18 binding protein
chr3_-_158450230 4.819 RARRES1
retinoic acid receptor responder (tazarotene induced) 1
chr3_-_158450271 4.795 NM_002888
NM_206963
RARRES1

retinoic acid receptor responder (tazarotene induced) 1

chr1_-_8003224 4.624 NM_001561
TNFRSF9
tumor necrosis factor receptor superfamily, member 9
chr11_+_71710662 4.475 NM_001145057
IL18BP
interleukin 18 binding protein
chr3_-_158450205 4.424 RARRES1
retinoic acid receptor responder (tazarotene induced) 1
chr3_+_122283139 4.253 NM_138287
DTX3L
deltex 3-like (Drosophila)
chr5_-_150467220 4.241 NM_001252390
TNIP1
TNFAIP3 interacting protein 1
chr11_-_72380107 4.184 NM_001146209
PDE2A
phosphodiesterase 2A, cGMP-stimulated
chr10_+_75673346 4.151 PLAU
plasminogen activator, urokinase
chr3_-_187463474 4.057 NM_001706
BCL6
B-cell CLL/lymphoma 6
chr11_-_102668822 4.053 MMP1
matrix metallopeptidase 1 (interstitial collagenase)
chr6_-_143266283 4.021 NM_006734
HIVEP2
human immunodeficiency virus type I enhancer binding protein 2
chr12_+_133656984 4.011 NM_003440
ZNF140
zinc finger protein 140
chr11_-_64647136 3.865 EHD1
EH-domain containing 1
chr3_-_187463227 3.835 BCL6
B-cell CLL/lymphoma 6
chr5_-_131826426 3.726 NM_002198
IRF1
interferon regulatory factor 1
chr1_-_153521717 3.514 NM_002960
S100A3
S100 calcium binding protein A3
chr17_+_32582295 3.465 NM_002982
CCL2
chemokine (C-C motif) ligand 2
chr14_+_24630421 3.430 NM_006084
IRF9
interferon regulatory factor 9
chr12_+_11802642 3.342 ETV6
ets variant 6
chr11_-_8892909 3.338 ST5
suppression of tumorigenicity 5
chr10_+_104154228 3.320 NM_001077493
NM_001077494
NFKB2

nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)

chr21_+_42792441 3.312 NM_001144925
MX1
myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)
chr19_+_57106622 3.301 NM_021216
ZNF71
zinc finger protein 71
chr5_-_121413967 3.300 LOX
lysyl oxidase
chr2_+_74757127 3.283 HTRA2
HtrA serine peptidase 2
chr13_-_43566301 3.281 NM_001002264
NM_033255
EPSTI1

epithelial stromal interaction 1 (breast)

chr11_-_102668892 3.261 NM_001145938
NM_002421
MMP1

matrix metallopeptidase 1 (interstitial collagenase)

chr14_-_55369163 3.259 NM_000161
NM_001024024
NM_001024070
NM_001024071
GCH1



GTP cyclohydrolase 1



chr4_+_154605421 3.254 NM_003264
TLR2
toll-like receptor 2
chr11_-_8832189 3.240 NM_213618
ST5
suppression of tumorigenicity 5
chr5_-_121413906 3.234 LOX
lysyl oxidase
chr4_-_122085475 3.231 NM_024873
TNIP3
TNFAIP3 interacting protein 3
chr4_-_2758018 3.203 NM_024309
TNIP2
TNFAIP3 interacting protein 2
chr5_-_121414011 3.183 NM_002317
LOX
lysyl oxidase
chr15_+_71184781 3.182 NM_001199017
NM_017691
NM_001199018
LRRC49


leucine rich repeat containing 49


chr4_+_154605441 3.179 TLR2
toll-like receptor 2
chr12_+_11802905 3.158 ETV6
ets variant 6
chr3_-_122283423 3.059 NM_001146103
NM_031458
PARP9

poly (ADP-ribose) polymerase family, member 9

chr4_-_2757750 3.038 NM_001161527
TNIP2
TNFAIP3 interacting protein 2
chrX_-_63450486 2.991 NM_130388
ASB12
ankyrin repeat and SOCS box containing 12
chr17_+_40440481 2.977 STAT5A
signal transducer and activator of transcription 5A
chr7_-_108096693 2.958 NM_001193582
NM_001193583
NM_001193584
NM_005010
NRCAM



neuronal cell adhesion molecule



chr2_+_74756986 2.942 HTRA2
HtrA serine peptidase 2
chr1_+_169075869 2.941 NM_001677
ATP1B1
ATPase, Na+/K+ transporting, beta 1 polypeptide
chr12_-_105322056 2.910 NM_032148
SLC41A2
solute carrier family 41, member 2
chr2_-_145277879 2.863 NM_001171653
NM_014795
ZEB2

zinc finger E-box binding homeobox 2

chr6_+_138188352 2.843 NM_006290
TNFAIP3
tumor necrosis factor, alpha-induced protein 3
chr17_-_41623652 2.825 NM_001079675
ETV4
ets variant 4
chr17_+_26662547 2.822 NM_021137
TNFAIP1
tumor necrosis factor, alpha-induced protein 1 (endothelial)
chr1_-_205782135 2.790 NM_173854
SLC41A1
solute carrier family 41, member 1
chr21_+_43636186 2.776 NM_207629
ABCG1
ATP-binding cassette, sub-family G (WHITE), member 1
chr17_+_74381419 2.764 SPHK1
sphingosine kinase 1
chr3_-_122283077 2.753 NM_001146102
NM_001146105
NM_001146104
NM_001146106
PARP9



poly (ADP-ribose) polymerase family, member 9



chr2_+_74757158 2.736 HTRA2
HtrA serine peptidase 2
chr14_+_55168831 2.711 SAMD4A
sterile alpha motif domain containing 4A
chr19_-_6737603 2.704 NM_001080452
GPR108
G protein-coupled receptor 108
chr17_+_74381186 2.691 NM_001142602
SPHK1
sphingosine kinase 1
chr9_-_123689172 2.677 NM_005658
TRAF1
TNF receptor-associated factor 1
chr1_+_110453232 2.659 NM_000757
NM_172210
NM_172212
CSF1


colony stimulating factor 1 (macrophage)


chr14_+_21538339 2.619 NM_018071
ARHGEF40
Rho guanine nucleotide exchange factor (GEF) 40
chr20_-_48530275 2.606 NM_001135773
SPATA2
spermatogenesis associated 2
chr22_+_36044412 2.582 NM_030641
APOL6
apolipoprotein L, 6
chr2_+_228678556 2.567 NM_001130046
NM_004591
CCL20

chemokine (C-C motif) ligand 20

chr19_+_10197023 2.561 C19orf66
chromosome 19 open reading frame 66
chr1_+_110453456 2.558 CSF1
colony stimulating factor 1 (macrophage)
chr6_+_36644236 2.521 NM_001220777
NM_078467
CDKN1A

cyclin-dependent kinase inhibitor 1A (p21, Cip1)

chr19_-_6737565 2.485 GPR108
G protein-coupled receptor 108
chr6_-_83903632 2.483 NM_001199917
PGM3
phosphoglucomutase 3
chr12_+_133657478 2.479 ZNF140
zinc finger protein 140
chr1_-_51787881 2.448 NM_001080494
TTC39A
tetratricopeptide repeat domain 39A
chr17_+_74380676 2.447 NM_001142601
NM_021972
NM_182965
SPHK1


sphingosine kinase 1


chr8_+_86157693 2.414 NM_198584
CA13
carbonic anhydrase XIII
chr20_+_55966440 2.394 NM_017495
NM_183425
RBM38

RNA binding motif protein 38

chr19_-_6737589 2.389 GPR108
G protein-coupled receptor 108
chr5_-_138862224 2.352 TMEM173
transmembrane protein 173
chr6_-_29527477 2.306 UBD
ubiquitin D
chr17_+_74380943 2.282 SPHK1
sphingosine kinase 1
chr3_-_64673330 2.280 NM_182920
ADAMTS9
ADAM metallopeptidase with thrombospondin type 1 motif, 9
chr11_-_8832881 2.279 NM_139157
ST5
suppression of tumorigenicity 5
chr9_-_32526164 2.270 NM_014314
DDX58
DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
chr10_+_115439425 2.266 NM_001227
NM_033338
NM_033339
CASP7


caspase 7, apoptosis-related cysteine peptidase


chr12_+_102271082 2.263 NM_018370
DRAM1
DNA-damage regulated autophagy modulator 1
chr3_-_45838112 2.214 SLC6A20
solute carrier family 6 (proline IMINO transporter), member 20
chr20_+_30945988 2.195 NM_001164603
NM_015338
ASXL1

additional sex combs like 1 (Drosophila)

chr15_-_55581969 2.168 NM_183235
RAB27A
RAB27A, member RAS oncogene family
chr2_-_11810254 2.150 NM_012344
NTSR2
neurotensin receptor 2
chr12_+_45686465 2.104 NM_001142678
ANO6
anoctamin 6
chr10_+_115439632 2.102 CASP7
caspase 7, apoptosis-related cysteine peptidase
chr6_+_31539875 2.090 NM_001159740
LTA
lymphotoxin alpha (TNF superfamily, member 1)
chr1_-_144994943 2.079 NM_001002812
NM_014644
NM_001002810
NM_001198834
NM_001195261
PDE4DIP




phosphodiesterase 4D interacting protein




chr3_+_171561138 2.077 NM_001164436
TMEM212
transmembrane protein 212
chr10_+_104155431 2.072 NM_002502
NFKB2
nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
chr5_-_138862342 2.052 NM_198282
TMEM173
transmembrane protein 173
chr11_-_615649 2.023 NM_004031
IRF7
interferon regulatory factor 7
chr12_-_7245006 1.996 NM_001733
C1R
complement component 1, r subcomponent
chr8_+_86158004 1.972 CA13
carbonic anhydrase XIII
chr5_+_52095929 1.970 PELO
pelota homolog (Drosophila)
chr12_-_7245048 1.969 C1R
complement component 1, r subcomponent
chr6_+_4836331 1.961 NM_001143970
CDYL
chromodomain protein, Y-like
chr3_-_79068542 1.957 NM_001145845
NM_133631
ROBO1

roundabout, axon guidance receptor, homolog 1 (Drosophila)

chr14_+_95078713 1.955 NM_001085
SERPINA3
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
chr6_-_30654978 1.955 PPP1R18
protein phosphatase 1, regulatory subunit 18
chr1_-_153931077 1.938 CRTC2
CREB regulated transcription coactivator 2
chr6_-_33547833 1.936 BAK1
BCL2-antagonist/killer 1
chr8_+_32405727 1.933 NM_001160002
NM_001160004
NM_001160005
NM_001160007
NM_001160008
NM_004495
NM_013956
NM_013957
NM_013958
NM_013960
NM_013964
NRG1










neuregulin 1










chr8_+_17396285 1.910 NM_001164771
NM_003046
SLC7A2

solute carrier family 7 (cationic amino acid transporter, y+ system), member 2

chr8_+_26435590 1.882 DPYSL2
dihydropyrimidinase-like 2
chr19_+_10196972 1.870 C19orf66
chromosome 19 open reading frame 66
chr9_+_137004913 1.870 NM_052821
WDR5
WD repeat domain 5
chr17_+_41158741 1.868 NM_005533
IFI35
interferon-induced protein 35
chr5_+_127419407 1.860 NM_001046
SLC12A2
solute carrier family 12 (sodium/potassium/chloride transporters), member 2
chr2_-_145277568 1.859 ZEB2
zinc finger E-box binding homeobox 2
chr8_-_48650683 1.842 CEBPD
CCAAT/enhancer binding protein (C/EBP), delta
chr11_-_615920 1.823 IRF7
interferon regulatory factor 7
chr5_+_31799030 1.816 NM_178140
PDZD2
PDZ domain containing 2
chr20_-_20693122 1.815 NM_020343
RALGAPA2
Ral GTPase activating protein, alpha subunit 2 (catalytic)
chr11_+_19372270 1.807 NM_001111018
NAV2
neuron navigator 2
chr1_-_144994839 1.797 PDE4DIP
phosphodiesterase 4D interacting protein
chr6_-_30654406 1.788 PPP1R18
protein phosphatase 1, regulatory subunit 18
chr21_-_37838724 1.785 NM_012130
CLDN14
claudin 14
chr4_-_122148620 1.785 NM_001244764
TNIP3
TNFAIP3 interacting protein 3
chr1_+_205473768 1.782 CDK18
cyclin-dependent kinase 18
chr8_-_48650703 1.769 NM_005195
CEBPD
CCAAT/enhancer binding protein (C/EBP), delta
chr1_-_153930911 1.763 CRTC2
CREB regulated transcription coactivator 2
chr1_-_153931096 1.753 NM_181715
CRTC2
CREB regulated transcription coactivator 2
chr6_-_83902921 1.740 NM_001199918
NM_001199919
NM_015599
PGM3


phosphoglucomutase 3


chr14_-_35344852 1.732 NM_013448
NM_182648
BAZ1A

bromodomain adjacent to zinc finger domain, 1A

chr3_+_38179968 1.723 NM_001172566
NM_001172567
NM_001172568
NM_001172569
NM_002468
MYD88




myeloid differentiation primary response gene (88)




chr11_+_102188180 1.722 NM_001165
NM_182962
BIRC3

baculoviral IAP repeat containing 3

chr11_-_615998 1.713 NM_001572
NM_004029
IRF7

interferon regulatory factor 7

chr4_-_76957139 1.681 NM_005409
CXCL11
chemokine (C-X-C motif) ligand 11
chr7_+_100728719 1.665 NM_030961
TRIM56
tripartite motif containing 56
chr22_-_31503484 1.636 NM_080430
SELM
selenoprotein M
chr11_-_65430427 1.634 NM_001145138
NM_001243984
NM_001243985
NM_021975
RELA



v-rel reticuloendotheliosis viral oncogene homolog A (avian)



chr11_-_60673854 1.630 PRPF19
PRP19/PSO4 pre-mRNA processing factor 19 homolog (S. cerevisiae)
chr2_+_74757116 1.627 HTRA2
HtrA serine peptidase 2
chr15_-_58358120 1.615 NM_001206897
NM_003888
NM_170696
ALDH1A2


aldehyde dehydrogenase 1 family, member A2


chr2_+_234263153 1.615 DGKD
diacylglycerol kinase, delta 130kDa
chr1_+_17906941 1.609 NM_001011722
ARHGEF10L
Rho guanine nucleotide exchange factor (GEF) 10-like
chr8_+_106331146 1.599 NM_012082
ZFPM2
zinc finger protein, multitype 2
chr3_+_14166582 1.599 TMEM43
transmembrane protein 43
chr6_+_144471631 1.595 NM_003764
STX11
syntaxin 11
chr6_+_36646455 1.576 NM_000389
NM_001220778
CDKN1A

cyclin-dependent kinase inhibitor 1A (p21, Cip1)

chr6_-_43595046 1.569 GTPBP2
GTP binding protein 2
chr12_-_15091441 1.565 NM_152321
ERP27
endoplasmic reticulum protein 27
chr3_+_14166543 1.561 TMEM43
transmembrane protein 43
chr19_+_44080951 1.554 NM_001193621
LOC390940
uncharacterized protein ENSP00000244321
chr19_+_42724498 1.545 ZNF526
zinc finger protein 526
chr15_+_45021319 1.535 TRIM69
tripartite motif containing 69
chr3_-_123603144 1.533 NM_053025
NM_053026
NM_053027
NM_053028
MYLK



myosin light chain kinase



chr11_+_118307072 1.533 NM_001197104
NM_005933
MLL

myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila)

chr10_+_103892786 1.524 NM_015062
PPRC1
peroxisome proliferator-activated receptor gamma, coactivator-related 1
chr8_-_8750739 1.517 NM_004225
MFHAS1
malignant fibrous histiocytoma amplified sequence 1
chr10_+_86131546 1.517 FAM190B
family with sequence similarity 190, member B
chr16_+_4674819 1.514 NM_001142289
NM_001142290
NM_001142291
NM_015246
MGRN1



mahogunin, ring finger 1



chr13_+_44453419 1.514 NM_001128303
LACC1
laccase (multicopper oxidoreductase) domain containing 1
chr6_-_36355342 1.511 NM_001207038
NM_001207035
NM_001207036
NM_001207037
NM_001207039
NM_001207040
NM_001207041
NM_016135
ETV7







ets variant 7







chr12_-_9913415 1.507 NM_001781
CD69
CD69 molecule
chr3_+_14166552 1.505 TMEM43
transmembrane protein 43
chr7_+_28530747 1.488 CREB5
cAMP responsive element binding protein 5
chr20_+_2795613 1.478 NM_080739
C20orf141
chromosome 20 open reading frame 141
chr12_+_133657439 1.478 ZNF140
zinc finger protein 140
chr22_-_36635552 1.453 APOL2
apolipoprotein L, 2
chr2_-_152146133 1.447 NMI
N-myc (and STAT) interactor
chr22_+_31608284 1.445 LIMK2
LIM domain kinase 2
chr16_+_31085751 1.433 ZNF646
zinc finger protein 646
chr10_+_90751044 1.431 FAS
Fas (TNF receptor superfamily, member 6)
chr16_+_4674829 1.430 MGRN1
mahogunin, ring finger 1
chr2_+_108994366 1.427 NM_006588
SULT1C4
sulfotransferase family, cytosolic, 1C, member 4

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.29 8.67e-06 GO:0048518 positive regulation of biological process
1.15 1.13e-05 GO:0050789 regulation of biological process
1.59 2.05e-05 GO:0006955 immune response
1.13 3.36e-05 GO:0065007 biological regulation
1.14 3.80e-04 GO:0050794 regulation of cellular process
1.21 2.24e-03 GO:0060255 regulation of macromolecule metabolic process
1.19 2.34e-03 GO:0019222 regulation of metabolic process
1.43 2.76e-03 GO:0009605 response to external stimulus
1.07 3.38e-03 GO:0009987 cellular process
1.25 3.79e-03 GO:0048522 positive regulation of cellular process
1.20 4.13e-03 GO:0080090 regulation of primary metabolic process
1.20 4.46e-03 GO:0031323 regulation of cellular metabolic process
1.36 5.46e-03 GO:0009893 positive regulation of metabolic process
1.58 8.17e-03 GO:0006935 chemotaxis
1.58 8.17e-03 GO:0042330 taxis
1.35 1.01e-02 GO:0051239 regulation of multicellular organismal process
1.43 1.49e-02 GO:0040011 locomotion
1.18 1.62e-02 GO:0023052 signaling
1.24 2.75e-02 GO:0048519 negative regulation of biological process
1.19 3.02e-02 GO:0007165 signal transduction
1.43 3.05e-02 GO:0048584 positive regulation of response to stimulus
1.34 3.06e-02 GO:0031325 positive regulation of cellular metabolic process
1.22 3.28e-02 GO:0031326 regulation of cellular biosynthetic process
1.42 3.98e-02 GO:0006952 defense response

Nothing significant found in compartment category.

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.15 1.09e-06 GO:0005515 protein binding
1.07 1.26e-03 GO:0005488 binding