Motif ID: TCF4_dimer.p2

Z-value: 1.042


Transcription factors associated with TCF4_dimer.p2:

Gene SymbolEntrez IDGene Name
TCF4 6925 transcription factor 4

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.p-valuePlot
TCF4chr18_-_532553610.087.2e-01Click!


Activity profile for motif TCF4_dimer.p2.

activity profile for motif TCF4_dimer.p2


Sorted Z-values histogram for motif TCF4_dimer.p2

Sorted Z-values for motif TCF4_dimer.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of TCF4_dimer.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr9_-_97401588 2.869 FBP1
fructose-1,6-bisphosphatase 1
chr17_+_39382878 2.684 NM_031961
KRTAP9-2
keratin associated protein 9-2
chr19_-_47137938 2.087 NM_033258
GNG8
guanine nucleotide binding protein (G protein), gamma 8
chr6_+_87865261 1.843 NM_015021
ZNF292
zinc finger protein 292
chr9_-_97401833 1.835 NM_000507
FBP1
fructose-1,6-bisphosphatase 1
chr9_-_97401746 1.815 FBP1
fructose-1,6-bisphosphatase 1
chr17_+_38119225 1.790 NM_178171
GSDMA
gasdermin A
chr9_+_127420690 1.750 MIR181A2HG
MIR181A2 host gene (non-protein coding)
chr16_-_88772807 1.689 NM_178841
RNF166
ring finger protein 166
chr6_+_18387580 1.580 NM_182757
RNF144B
ring finger protein 144B
chr20_+_43029973 1.557 HNF4A
hepatocyte nuclear factor 4, alpha
chr6_-_139695349 1.494 NM_001168389
NM_001168388
CITED2

Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2

chr11_+_71238312 1.410 NM_001012503
KRTAP5-7
keratin associated protein 5-7
chr19_+_6464259 1.402 NM_139161
NM_174881
CRB3

crumbs homolog 3 (Drosophila)

chr4_-_149363498 1.401 NM_000901
NM_001166104
NR3C2

nuclear receptor subfamily 3, group C, member 2

chr16_-_88772732 1.397 NM_001171815
RNF166
ring finger protein 166
chr8_-_93029864 1.365 NM_175636
RUNX1T1
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
chrX_-_152938742 1.329 NM_001135740
PNCK
pregnancy up-regulated non-ubiquitously expressed CaM kinase
chr11_+_118868841 1.327 NM_198489
CCDC84
coiled-coil domain containing 84
chrX_-_152939256 1.290 PNCK
pregnancy up-regulated non-ubiquitously expressed CaM kinase
chr19_-_17356022 1.273 NM_005234
NR2F6
nuclear receptor subfamily 2, group F, member 6
chr6_+_132891460 1.267 NM_175067
TAAR6
trace amine associated receptor 6
chr3_-_39234071 1.256 NM_194293
NM_001198621
XIRP1

xin actin-binding repeat containing 1

chr13_-_80912971 1.251 SPRY2
sprouty homolog 2 (Drosophila)
chr15_+_31196106 1.234 FAN1
FANCD2/FANCI-associated nuclease 1
chr17_+_73521744 1.214 NM_001015002
NM_001031803
NM_004524
LLGL2


lethal giant larvae homolog 2 (Drosophila)


chr7_+_17338182 1.201 NM_001621
AHR
aryl hydrocarbon receptor
chr1_-_238054221 1.199 NM_021186
ZP4
zona pellucida glycoprotein 4
chr10_+_8096772 1.138 GATA3
GATA binding protein 3
chr13_+_78271820 1.123 NM_001242868
SLAIN1
SLAIN motif family, member 1
chr1_+_6615337 1.117 NM_138697
NM_177540
TAS1R1

taste receptor, type 1, member 1

chr17_-_39306053 1.103 NM_033188
KRTAP4-5
keratin associated protein 4-5
chr1_+_65720091 1.081 LOC645195
DNAJC6
uncharacterized LOC645195
DnaJ (Hsp40) homolog, subfamily C, member 6
chr2_-_105946104 1.079 NM_001142621
NM_004257
TGFBRAP1

transforming growth factor, beta receptor associated protein 1

chr11_-_1629614 1.069 NM_001012708
KRTAP5-3
keratin associated protein 5-3
chrX_-_13956530 1.056 GPM6B
glycoprotein M6B
chr20_+_58515408 1.050 NM_001190827
NM_022106
C20orf177

chromosome 20 open reading frame 177

chr17_+_39394269 1.025 NM_031963
KRTAP9-8
keratin associated protein 9-8
chr9_+_140172273 1.000 NM_017723
C9orf167
chromosome 9 open reading frame 167
chr1_-_40367539 0.998 NM_001033081
NM_001033082
NM_005376
MYCL1


v-myc myelocytomatosis viral oncogene homolog 1, lung carcinoma derived (avian)


chr8_+_144816287 0.997 LOC100128338
uncharacterized LOC100128338
chr7_-_27183225 0.986 NM_019102
HOXA5
homeobox A5
chr16_+_68771304 0.985 CDH1
cadherin 1, type 1, E-cadherin (epithelial)
chr9_-_131940538 0.982 NM_203434
IER5L
immediate early response 5-like
chr6_-_139695784 0.968 NM_006079
CITED2
Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
chr6_-_139695739 0.956 CITED2
Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
chr14_+_38678280 0.941 SSTR1
somatostatin receptor 1
chr19_-_7939325 0.934 NM_001190467
FLJ22184
putative uncharacterized protein FLJ22184
chr8_-_127570465 0.932 FAM84B
family with sequence similarity 84, member B
chr17_-_39316982 0.931 NM_032524
KRTAP4-4
keratin associated protein 4-4
chr1_+_1981902 0.928 NM_002744
PRKCZ
protein kinase C, zeta
chr9_-_86432546 0.906 NM_001135953
NM_025211
GKAP1

G kinase anchoring protein 1

chr20_-_62680880 0.903 NM_018419
SOX18
SRY (sex determining region Y)-box 18
chr7_-_27224762 0.896 NM_005523
HOXA11
homeobox A11
chr2_-_165477818 0.893 GRB14
growth factor receptor-bound protein 14
chr16_+_83932729 0.890 NM_012213
MLYCD
malonyl-CoA decarboxylase
chr1_-_23885916 0.888 ID3
inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
chr17_-_21156577 0.882 NM_152914
C17orf103
chromosome 17 open reading frame 103
chr9_-_35748875 0.864 GBA2
glucosidase, beta (bile acid) 2
chr1_+_231114794 0.859 NM_022786
ARV1
ARV1 homolog (S. cerevisiae)
chr16_+_53133063 0.852 CHD9
chromodomain helicase DNA binding protein 9
chr15_-_56035176 0.846 NM_173814
PRTG
protogenin
chr17_+_4981754 0.819 ZFP3
zinc finger protein 3 homolog (mouse)
chr8_+_120220554 0.819 NM_052886
MAL2
mal, T-cell differentiation protein 2 (gene/pseudogene)
chr7_+_12726910 0.816 NM_001195396
NM_005738
ARL4A

ADP-ribosylation factor-like 4A

chr19_+_38810461 0.812 NM_004823
KCNK6
potassium channel, subfamily K, member 6
chr3_+_32280154 0.812 NM_178868
CMTM8
CKLF-like MARVEL transmembrane domain containing 8
chr9_-_126030792 0.811 NM_018387
STRBP
spermatid perinuclear RNA binding protein
chr1_+_89990442 0.810 LRRC8B
leucine rich repeat containing 8 family, member B
chr10_+_8096633 0.802 NM_001002295
NM_002051
GATA3

GATA binding protein 3

chr3_-_167813175 0.796 NM_014498
GOLIM4
golgi integral membrane protein 4
chr1_+_231114839 0.793


chrX_-_107018889 0.790 TSC22D3
TSC22 domain family, member 3
chr19_-_49222956 0.782 NM_001130915
MAMSTR
MEF2 activating motif and SAP domain containing transcriptional regulator
chr3_+_32280211 0.774 CMTM8
CKLF-like MARVEL transmembrane domain containing 8
chr10_+_8097350 0.773 GATA3
GATA binding protein 3
chr17_+_4981721 0.768 NM_153018
ZFP3
zinc finger protein 3 homolog (mouse)
chr6_+_16129321 0.761 MYLIP
myosin regulatory light chain interacting protein
chr17_+_1958354 0.760 NM_006497
HIC1
hypermethylated in cancer 1
chr17_-_7123368 0.756 NM_001365
DLG4
discs, large homolog 4 (Drosophila)
chr20_+_44098392 0.745 NM_006103
WFDC2
WAP four-disulfide core domain 2
chr17_-_39341126 0.741 NM_033060
KRTAP4-1
keratin associated protein 4-1
chr4_+_186317964 0.739 ANKRD37
ankyrin repeat domain 37
chr2_-_7005764 0.737 NM_207315
CMPK2
cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial
chr19_+_38810540 0.735 KCNK6
potassium channel, subfamily K, member 6
chr12_-_95044205 0.733 NM_020698
TMCC3
transmembrane and coiled-coil domain family 3
chr4_-_16085309 0.728 PROM1
prominin 1
chrX_-_154688260 0.718 NM_001007523
NM_001007524
NM_012151
F8A2
F8A3
F8A1
coagulation factor VIII-associated 2
coagulation factor VIII-associated 3
coagulation factor VIII-associated 1
chr9_-_126030854 0.717 NM_001171137
STRBP
spermatid perinuclear RNA binding protein
chr10_+_94833231 0.714 NM_057157
CYP26A1
cytochrome P450, family 26, subfamily A, polypeptide 1
chr1_+_150255228 0.708 NM_144697
C1orf51
chromosome 1 open reading frame 51
chr5_+_137801178 0.694 NM_001964
EGR1
early growth response 1
chr13_-_28194677 0.692 NM_153371
LNX2
ligand of numb-protein X 2
chr19_+_54058493 0.691 NM_001079907
ZNF331
zinc finger protein 331
chr19_-_10047014 0.691 NM_058164
OLFM2
olfactomedin 2
chr18_+_3247815 0.690 MYL12A
myosin, light chain 12A, regulatory, non-sarcomeric
chr1_-_22109450 0.689 USP48
ubiquitin specific peptidase 48
chr13_+_31480311 0.689 NM_032849
C13orf33
chromosome 13 open reading frame 33
chr4_+_100871625 0.682 LOC256880
uncharacterized LOC256880
chr19_+_54042041 0.678 NM_001253800
ZNF331
zinc finger protein 331
chr19_-_39368889 0.672 NM_001195833
NM_198445
RINL

Ras and Rab interactor-like

chr11_+_7535000 0.671 NM_003621
PPFIBP2
PTPRF interacting protein, binding protein 2 (liprin beta 2)
chrX_+_154114609 0.671 NM_001007523
NM_001007524
NM_012151
F8A2
F8A3
F8A1
coagulation factor VIII-associated 2
coagulation factor VIII-associated 3
coagulation factor VIII-associated 1
chr8_-_93111915 0.670 NM_001198628
RUNX1T1
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
chr14_-_107078578 0.667


chr19_-_11308184 0.666 NM_001136191
KANK2
KN motif and ankyrin repeat domains 2
chr2_-_165477986 0.665 GRB14
growth factor receptor-bound protein 14
chr11_-_1643324 0.657 NM_001012709
KRTAP5-4
keratin associated protein 5-4
chr3_-_128207366 0.656 NM_001145661
GATA2
GATA binding protein 2
chr1_+_244214552 0.655 NM_205768
ZNF238
zinc finger protein 238
chr6_+_34857021 0.654 NM_015245
ANKS1A
ankyrin repeat and sterile alpha motif domain containing 1A
chr22_+_22735202 0.651


chr12_-_49392909 0.647 NM_015086
DDN
dendrin
chr13_-_33780142 0.646 NM_001243474
NM_052851
STARD13

StAR-related lipid transfer (START) domain containing 13

chr19_+_46001730 0.645 NM_001080401
PPM1N
protein phosphatase, Mg2+/Mn2+ dependent, 1N (putative)
chr3_-_184079266 0.641 NM_001171087
NM_001171088
NM_001171089
NM_004366
CLCN2



chloride channel 2



chr10_-_50747080 0.639 NM_000124
ERCC6
PGBD3
excision repair cross-complementing rodent repair deficiency, complementation group 6
piggyBac transposable element derived 3
chr1_-_45672225 0.637 NM_020883
ZSWIM5
zinc finger, SWIM-type containing 5
chr8_-_93115453 0.637 NM_001198633
NM_175634
RUNX1T1

runt-related transcription factor 1; translocated to, 1 (cyclin D-related)

chr1_+_87794576 0.635 LMO4
LIM domain only 4
chr1_+_155147051 0.634 TRIM46
tripartite motif containing 46
chr13_+_50656306 0.631 DLEU1
deleted in lymphocytic leukemia 1 (non-protein coding)
chr19_-_45826131 0.629 CKM
creatine kinase, muscle
chr8_+_37654833 0.629 GPR124
G protein-coupled receptor 124
chr4_-_101111606 0.627 NM_145244
DDIT4L
DNA-damage-inducible transcript 4-like
chr5_+_68788387 0.624 NM_001205254
OCLN
occludin
chr5_+_176560056 0.623 NM_172349
NSD1
nuclear receptor binding SET domain protein 1
chr17_-_45899118 0.622 OSBPL7
oxysterol binding protein-like 7
chr17_-_47841517 0.621 NM_030802
FAM117A
family with sequence similarity 117, member A
chr2_-_241622309 0.619 NM_001102467
AQP12B
aquaporin 12B
chr17_-_39334439 0.615 NM_033062
KRTAP4-2
keratin associated protein 4-2
chr2_-_220436010 0.615 OBSL1
obscurin-like 1
chr11_+_7535213 0.615 PPFIBP2
PTPRF interacting protein, binding protein 2 (liprin beta 2)
chr13_-_28194538 0.603 LNX2
ligand of numb-protein X 2
chr8_-_57123858 0.603 NM_001114634
NM_001114635
NM_002655
PLAG1


pleiomorphic adenoma gene 1


chr8_-_57123827 0.601 PLAG1
pleiomorphic adenoma gene 1
chr9_-_86153048 0.597 NM_001244959
NM_174938
FRMD3

FERM domain containing 3

chrX_-_50557019 0.596 NM_020717
SHROOM4
shroom family member 4
chr20_+_42574535 0.595 NM_001098798
TOX2
TOX high mobility group box family member 2
chr17_-_47841468 0.594 FAM117A
family with sequence similarity 117, member A
chr20_+_1246959 0.589 NM_014723
SNPH
syntaphilin
chr2_+_74741565 0.589 NM_016170
TLX2
T-cell leukemia homeobox 2
chr17_-_39191100 0.586 NM_030966
KRTAP1-3
keratin associated protein 1-3
chr12_+_57920425 0.585 MBD6
methyl-CpG binding domain protein 6
chr6_+_2766228 0.582 WRNIP1
Werner helicase interacting protein 1
chr10_-_103347978 0.577 NM_001174084
NM_001174085
NM_013274
POLL


polymerase (DNA directed), lambda


chr15_-_75660944 0.574 MAN2C1
mannosidase, alpha, class 2C, member 1
chr19_+_13263890 0.571 IER2
immediate early response 2
chr2_+_120517206 0.571 NM_002830
PTPN4
protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte)
chr2_+_205410556 0.568 PARD3B
par-3 partitioning defective 3 homolog B (C. elegans)
chr11_+_45944155 0.567 GYLTL1B
glycosyltransferase-like 1B
chr11_+_118175294 0.563 NM_000733
CD3E
CD3e molecule, epsilon (CD3-TCR complex)
chr12_-_91348950 0.562 NM_152638
C12orf12
chromosome 12 open reading frame 12
chr9_-_127905715 0.561 NM_001144877
NM_173690
SCAI

suppressor of cancer cell invasion

chr2_-_166650770 0.560 NM_004482
GALNT3
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 3 (GalNAc-T3)
chrX_-_107019001 0.559 NM_198057
TSC22D3
TSC22 domain family, member 3
chr4_+_89300110 0.559 HERC6
hect domain and RLD 6
chr17_-_45899133 0.556 NM_145798
OSBPL7
oxysterol binding protein-like 7
chr7_+_12727204 0.556 ARL4A
ADP-ribosylation factor-like 4A
chr2_-_74667553 0.552 NM_001015056
NM_033046
RTKN

rhotekin

chr8_-_110657025 0.552 NM_001099753
NM_001099754
NM_001099755
SYBU


syntabulin (syntaxin-interacting)


chr9_-_131940481 0.550 IER5L
immediate early response 5-like
chr8_+_95835586 0.550 INTS8
integrator complex subunit 8
chr11_-_19262424 0.550 NM_024680
E2F8
E2F transcription factor 8
chr13_+_28194846 0.542 NM_001206559
POLR1D
polymerase (RNA) I polypeptide D, 16kDa
chr2_+_203499819 0.541 NM_173511
FAM117B
family with sequence similarity 117, member B
chr1_+_244214576 0.540 ZNF238
zinc finger protein 238
chr12_+_1929658 0.539 LRTM2
leucine-rich repeats and transmembrane domains 2
chr3_+_184056304 0.537 FAM131A
family with sequence similarity 131, member A
chr10_+_99258615 0.536 NM_024954
UBTD1
ubiquitin domain containing 1
chr1_+_87797371 0.532 LMO4
LIM domain only 4
chr14_-_20929484 0.529 TMEM55B
transmembrane protein 55B
chr2_-_211018294 0.523 C2orf67
chromosome 2 open reading frame 67
chr1_+_2005424 0.522 NM_001242874
PRKCZ
protein kinase C, zeta
chr7_+_12726413 0.519 NM_001037164
NM_212460
ARL4A

ADP-ribosylation factor-like 4A

chr22_-_31741761 0.518 PATZ1
POZ (BTB) and AT hook containing zinc finger 1
chr1_+_151630710 0.515 SNX27
sorting nexin family member 27
chr12_+_107168336 0.512 NM_018157
RIC8B
resistance to inhibitors of cholinesterase 8 homolog B (C. elegans)
chr1_-_59248287 0.512 JUN
jun proto-oncogene
chr19_-_36036870 0.511 LOC100506469
uncharacterized LOC100506469
chr3_-_49058426 0.510 NM_018114
DALRD3
DALR anticodon binding domain containing 3
chr5_+_176237435 0.509 NM_133369
UNC5A
unc-5 homolog A (C. elegans)
chr8_-_29206321 0.509 NM_057158
DUSP4
dual specificity phosphatase 4
chr1_-_53018630 0.506 ZCCHC11
zinc finger, CCHC domain containing 11
chr17_+_74722892 0.506 NM_001080510
NM_001206983
NM_001206984
NM_001206985
NM_001206986
NM_001206987
METTL23





methyltransferase like 23





chr1_+_39875175 0.503 NM_015038
KIAA0754
KIAA0754
chr5_-_132948195 0.502 FSTL4
follistatin-like 4
chr19_+_35773409 0.501 NM_021175
HAMP
hepcidin antimicrobial peptide
chr17_-_47439326 0.498 NM_001145365
NM_014897
ZNF652

zinc finger protein 652

chr5_+_78531848 0.493 NM_152405
JMY
junction mediating and regulatory protein, p53 cofactor
chr10_-_103347882 0.493 POLL
polymerase (DNA directed), lambda
chr9_-_92112887 0.493 SEMA4D
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D
chr10_-_77161424 0.492 NM_032772
ZNF503
zinc finger protein 503
chr15_+_40532034 0.489 NM_020168
PAK6
p21 protein (Cdc42/Rac)-activated kinase 6
chr2_-_220436267 0.487 NM_001173408
NM_001173431
NM_015311
OBSL1


obscurin-like 1


chr10_-_50747038 0.486 ERCC6
excision repair cross-complementing rodent repair deficiency, complementation group 6
chr9_+_131644427 0.480 LRRC8A
leucine rich repeat containing 8 family, member A
chr19_-_11305186 0.480 NM_015493
KANK2
KN motif and ankyrin repeat domains 2
chr8_+_38034066 0.478 NM_001204878
NM_004874
BAG4

BCL2-associated athanogene 4

chr4_+_89299980 0.475 HERC6
hect domain and RLD 6

Gene Ontology Analysis

Nothing significant found in process category.

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.05 5.35e-04 GO:0044424 intracellular part
1.06 9.17e-04 GO:0005737 cytoplasm
1.04 2.38e-03 GO:0005622 intracellular
1.25 9.09e-03 GO:0031988 membrane-bounded vesicle
1.07 1.57e-02 GO:0044444 cytoplasmic part
1.25 1.71e-02 GO:0016023 cytoplasmic membrane-bounded vesicle
1.23 2.22e-02 GO:0031982 vesicle
1.24 2.39e-02 GO:0031410 cytoplasmic vesicle
1.71 4.39e-02 GO:0045095 keratin filament

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.09 5.82e-06 GO:0005515 protein binding