Motif ID: TFAP4.p2

Z-value: 1.160


Transcription factors associated with TFAP4.p2:

Gene SymbolEntrez IDGene Name
TFAP4 7023 transcription factor AP-4 (activating enhancer binding protein 4)

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.p-valuePlot
TFAP4chr16_-_4323000,
chr16_-_4322695
-0.135.2e-01Click!


Activity profile for motif TFAP4.p2.

activity profile for motif TFAP4.p2


Sorted Z-values histogram for motif TFAP4.p2

Sorted Z-values for motif TFAP4.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of TFAP4.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr17_+_39382878 6.464 NM_031961
KRTAP9-2
keratin associated protein 9-2
chr13_-_72440143 2.976 DACH1
dachshund homolog 1 (Drosophila)
chr1_+_47489239 2.953 NM_178033
CYP4X1
cytochrome P450, family 4, subfamily X, polypeptide 1
chr8_-_28243589 2.439 ZNF395
zinc finger protein 395
chr3_-_18480203 2.293 NM_001131010
SATB1
SATB homeobox 1
chrX_-_54522318 2.279 NM_004463
FGD1
FYVE, RhoGEF and PH domain containing 1
chr21_+_46020496 2.188 NM_198689
KRTAP10-7
keratin associated protein 10-7
chr13_-_72440557 2.141 DACH1
dachshund homolog 1 (Drosophila)
chr1_+_78354199 2.129 NM_001172309
NM_144573
NEXN

nexilin (F actin binding protein)

chr20_-_23066828 2.122 NM_012072
CD93
CD93 molecule
chr20_+_37434294 2.078 NM_001172735
NM_015568
PPP1R16B

protein phosphatase 1, regulatory subunit 16B

chr8_-_28243941 2.014 NM_018660
ZNF395
zinc finger protein 395
chr7_+_17338182 2.005 NM_001621
AHR
aryl hydrocarbon receptor
chr2_+_189156730 1.999 GULP1
GULP, engulfment adaptor PTB domain containing 1
chr9_+_43684800 1.996 NM_001201380
CNTNAP3B
contactin associated protein-like 3B
chr2_+_189156603 1.942 GULP1
GULP, engulfment adaptor PTB domain containing 1
chr6_-_13486986 1.920 GFOD1
glucose-fructose oxidoreductase domain containing 1
chr10_-_116392099 1.912 ABLIM1
actin binding LIM protein 1
chr2_-_152684963 1.867 NM_001037174
NM_012097
NM_177985
ARL5A


ADP-ribosylation factor-like 5A


chr1_+_90098693 1.865 LRRC8C
leucine rich repeat containing 8 family, member C
chr2_-_152684933 1.830 ARL5A
ADP-ribosylation factor-like 5A
chrX_+_118109314 1.823 LONRF3
LON peptidase N-terminal domain and ring finger 3
chr8_-_127570710 1.814 NM_174911
FAM84B
family with sequence similarity 84, member B
chr2_-_152684882 1.709 ARL5A
ADP-ribosylation factor-like 5A
chr7_+_150148078 1.708 GIMAP8
GTPase, IMAP family member 8
chr11_+_68079999 1.670 NM_002335
LRP5
low density lipoprotein receptor-related protein 5
chr14_+_24867926 1.631 NM_025081
NYNRIN
NYN domain and retroviral integrase containing
chr18_+_20715726 1.610 NM_001100619
CABLES1
Cdk5 and Abl enzyme substrate 1
chr9_-_80646150 1.573 NM_002072
GNAQ
guanine nucleotide binding protein (G protein), q polypeptide
chr6_+_84743250 1.552 NM_138409
MRAP2
melanocortin 2 receptor accessory protein 2
chr3_+_134514044 1.552 NM_004441
EPHB1
EPH receptor B1
chr3_+_43328001 1.490 NM_001100594
NM_017719
SNRK

SNF related kinase

chr7_+_155089614 1.490 INSIG1
insulin induced gene 1
chr19_-_19051112 1.466 NM_001145722
NM_001145721
HOMER3

homer homolog 3 (Drosophila)

chr19_+_41699140 1.438 CYP2S1
cytochrome P450, family 2, subfamily S, polypeptide 1
chr1_+_61547625 1.414 NM_001134673
NM_005595
NFIA

nuclear factor I/A

chr1_+_90098643 1.401 NM_032270
LRRC8C
leucine rich repeat containing 8 family, member C
chr2_+_12856813 1.399 NM_021643
TRIB2
tribbles homolog 2 (Drosophila)
chr20_-_47444282 1.391 PREX1
phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1
chr1_+_207494816 1.367 NM_000574
NM_001114752
CD55

CD55 molecule, decay accelerating factor for complement (Cromer blood group)

chr12_+_27397077 1.353 NM_015000
STK38L
serine/threonine kinase 38 like
chr4_+_55523906 1.342 NM_000222
NM_001093772
KIT

v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog

chr4_-_186577858 1.324 SORBS2
sorbin and SH3 domain containing 2
chr8_+_97506020 1.320 SDC2
syndecan 2
chr5_-_112630301 1.310 MCC
mutated in colorectal cancers
chr8_-_27941387 1.293 NM_001010906
C8orf80
chromosome 8 open reading frame 80
chr1_+_207495009 1.288 CD55
CD55 molecule, decay accelerating factor for complement (Cromer blood group)
chr7_+_155089483 1.284 NM_005542
NM_198336
NM_198337
INSIG1


insulin induced gene 1


chr22_-_37882214 1.272 NM_001166343
NM_002405
MFNG

MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase

chr11_-_2018703 1.265 H19
H19, imprinted maternally expressed transcript (non-protein coding)
chr7_+_1097140 1.261 NM_138445
GPR146
G protein-coupled receptor 146
chr8_+_56792392 1.260 LYN
v-yes-1 Yamaguchi sarcoma viral related oncogene homolog
chr1_+_32050510 1.258 TINAGL1
tubulointerstitial nephritis antigen-like 1
chr8_-_127570465 1.254 FAM84B
family with sequence similarity 84, member B
chr20_-_62680880 1.254 NM_018419
SOX18
SRY (sex determining region Y)-box 18
chr12_+_52695648 1.238 NM_002284
KRT86
keratin 86
chr8_+_37654757 1.238 GPR124
G protein-coupled receptor 124
chr3_+_32148000 1.232 NM_015141
GPD1L
glycerol-3-phosphate dehydrogenase 1-like
chr12_+_82752275 1.224 NM_032230
C12orf26
chromosome 12 open reading frame 26
chr3_+_32148136 1.212 GPD1L
glycerol-3-phosphate dehydrogenase 1-like
chr8_+_37654833 1.212 GPR124
G protein-coupled receptor 124
chr19_-_52150007 1.195 NM_001098612
SIGLEC14
sialic acid binding Ig-like lectin 14
chr11_+_133938965 1.171 JAM3
junctional adhesion molecule 3
chr14_-_23284617 1.171 SLC7A7
solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
chrX_-_125686792 1.165 NM_178470
DCAF12L1
DDB1 and CUL4 associated factor 12-like 1
chr1_-_59043165 1.158 NM_002353
TACSTD2
tumor-associated calcium signal transducer 2
chr2_-_152684689 1.148 ARL5A
ADP-ribosylation factor-like 5A
chr14_-_92414004 1.147 NM_006329
FBLN5
fibulin 5
chr4_+_41362750 1.127 NM_001112717
NM_001112718
NM_014988
LIMCH1


LIM and calponin homology domains 1


chr12_+_12938540 1.124 NM_030817
APOLD1
apolipoprotein L domain containing 1
chr1_+_207495086 1.123 CD55
CD55 molecule, decay accelerating factor for complement (Cromer blood group)
chr7_+_102553343 1.113 NM_001031692
NM_005824
LRRC17

leucine rich repeat containing 17

chr1_-_22263676 1.105 NM_005529
HSPG2
heparan sulfate proteoglycan 2
chr7_+_150147882 1.103 GIMAP8
GTPase, IMAP family member 8
chr18_+_77623667 1.098 NM_012283
KCNG2
potassium voltage-gated channel, subfamily G, member 2
chr14_-_23284565 1.098 SLC7A7
solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
chr2_-_220436010 1.098 OBSL1
obscurin-like 1
chr3_+_134514300 1.089 EPHB1
EPH receptor B1
chr4_+_4861371 1.088 NM_002448
MSX1
msh homeobox 1
chr12_-_52585686 1.085 NM_001081492
NM_182507
KRT80

keratin 80

chr9_-_84303595 1.078 NM_005077
TLE1
transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
chr11_+_59522801 1.074 STX3
syntaxin 3
chr1_-_228135587 1.073 NM_003395
WNT9A
wingless-type MMTV integration site family, member 9A
chr11_+_71238312 1.057 NM_001012503
KRTAP5-7
keratin associated protein 5-7
chr9_-_129884885 1.054 ANGPTL2
angiopoietin-like 2
chr18_-_22930826 1.054


chr8_+_97505895 1.053 SDC2
syndecan 2
chr17_+_81037504 1.051 NM_001004431
METRNL
meteorin, glial cell differentiation regulator-like
chr14_-_21270537 1.050 NM_198232
RNASE1
ribonuclease, RNase A family, 1 (pancreatic)
chr17_-_39183453 1.049 NM_031957
KRTAP1-5
keratin associated protein 1-5
chr7_+_150147936 1.047 NM_175571
GIMAP8
GTPase, IMAP family member 8
chr1_+_10092990 1.044 NM_001105562
NM_006048
UBE4B

ubiquitination factor E4B

chr10_-_64578926 1.042 NM_001136178
EGR2
early growth response 2
chr15_+_57668702 1.038 NM_001252335
NM_032866
CGNL1

cingulin-like 1

chr2_-_74667553 1.031 NM_001015056
NM_033046
RTKN

rhotekin

chr1_+_207495070 1.026 CD55
CD55 molecule, decay accelerating factor for complement (Cromer blood group)
chr12_-_12503135 1.001 NM_018050
MANSC1
MANSC domain containing 1
chr9_-_39288061 0.995 NM_033655
CNTNAP3
contactin associated protein-like 3
chr8_+_37654395 0.989 NM_032777
GPR124
G protein-coupled receptor 124
chr7_+_116502529 0.980 NM_006136
CAPZA2
capping protein (actin filament) muscle Z-line, alpha 2
chr6_-_13487772 0.977 NM_001242629
NM_018988
GFOD1

glucose-fructose oxidoreductase domain containing 1

chr8_+_37654406 0.974 GPR124
G protein-coupled receptor 124
chr9_+_140172273 0.972 NM_017723
C9orf167
chromosome 9 open reading frame 167
chr1_+_77747602 0.961 NM_174858
AK5
adenylate kinase 5
chr10_+_102106958 0.956 SCD
stearoyl-CoA desaturase (delta-9-desaturase)
chr7_-_27213873 0.955 NM_018951
HOXA10
homeobox A10
chr8_-_48650683 0.950 CEBPD
CCAAT/enhancer binding protein (C/EBP), delta
chr6_+_32006092 0.948 NM_000500
NM_001128590
CYP21A2

cytochrome P450, family 21, subfamily A, polypeptide 2

chr8_+_97506141 0.947 SDC2
syndecan 2
chr17_+_68165660 0.939 NM_000891
KCNJ2
potassium inwardly-rectifying channel, subfamily J, member 2
chr14_-_92413738 0.937 FBLN5
fibulin 5
chr8_+_56792399 0.926 LYN
v-yes-1 Yamaguchi sarcoma viral related oncogene homolog
chrX_+_77166178 0.921 NM_000052
ATP7A
ATPase, Cu++ transporting, alpha polypeptide
chr2_-_209119751 0.918 NM_005896
IDH1
isocitrate dehydrogenase 1 (NADP+), soluble
chr20_-_47444404 0.917 NM_020820
PREX1
phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1
chr4_+_87856152 0.909 NM_001166693
AFF1
AF4/FMR2 family, member 1
chr9_+_115631814 0.904 SNX30
sorting nexin family member 30
chr5_-_111093792 0.902 NM_001142477
NM_001142476
C5orf13

chromosome 5 open reading frame 13

chr9_+_90112419 0.884 DAPK1
death-associated protein kinase 1
chr4_-_102268626 0.879 NM_000944
NM_001130691
NM_001130692
PPP3CA


protein phosphatase 3, catalytic subunit, alpha isozyme


chr10_-_105212149 0.879 NM_015916
CALHM2
calcium homeostasis modulator 2
chr1_+_10093149 0.878 UBE4B
ubiquitination factor E4B
chr1_-_1182101 0.876 NM_001014980
FAM132A
family with sequence similarity 132, member A
chr9_+_139606916 0.873 NM_152421
FAM69B
family with sequence similarity 69, member B
chr17_+_39394269 0.870 NM_031963
KRTAP9-8
keratin associated protein 9-8
chr3_+_196366655 0.868 NM_198565
LRRC33
leucine rich repeat containing 33
chr11_-_2018568 0.867 H19
H19, imprinted maternally expressed transcript (non-protein coding)
chr5_-_112630557 0.859 NM_002387
MCC
mutated in colorectal cancers
chr9_-_129884998 0.859 NM_012098
ANGPTL2
angiopoietin-like 2
chr2_-_220436267 0.855 NM_001173408
NM_001173431
NM_015311
OBSL1


obscurin-like 1


chr4_+_186317837 0.850 NM_181726
ANKRD37
ankyrin repeat domain 37
chr14_-_21271002 0.849 NM_002933
NM_198234
NM_198235
RNASE1


ribonuclease, RNase A family, 1 (pancreatic)


chr10_-_126849010 0.849 CTBP2
C-terminal binding protein 2
chr12_+_13349720 0.848 EMP1
epithelial membrane protein 1
chr11_+_59522905 0.845 STX3
syntaxin 3
chr10_-_97321094 0.843 NM_015385
NM_024991
SORBS1

sorbin and SH3 domain containing 1

chr4_+_186317964 0.842 ANKRD37
ankyrin repeat domain 37
chr6_+_15245702 0.841 JARID2
jumonji, AT rich interactive domain 2
chr4_+_186317892 0.840 ANKRD37
ankyrin repeat domain 37
chr1_+_78444922 0.840 DNAJB4
DnaJ (Hsp40) homolog, subfamily B, member 4
chr19_+_41699076 0.830 NM_030622
CYP2S1
cytochrome P450, family 2, subfamily S, polypeptide 1
chr1_+_10003526 0.829 NMNAT1
nicotinamide nucleotide adenylyltransferase 1
chr14_+_65879694 0.827 FUT8
fucosyltransferase 8 (alpha (1,6) fucosyltransferase)
chr8_+_95732101 0.827 NM_181787
DPY19L4
dpy-19-like 4 (C. elegans)
chr12_-_7848324 0.822 NM_020634
GDF3
growth differentiation factor 3
chr9_+_134165075 0.822 NM_032728
PPAPDC3
phosphatidic acid phosphatase type 2 domain containing 3
chr12_-_54812936 0.817 ITGA5
integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
chrX_+_80457597 0.815 SH3BGRL
SH3 domain binding glutamic acid-rich protein like
chr11_-_67120943 0.815 NM_021173
POLD4
polymerase (DNA-directed), delta 4
chr1_-_182360181 0.810 GLUL
glutamate-ammonia ligase
chr2_-_111230651 0.808 NM_001205288
NM_033514
LIMS3-LOC440895
LIMS3L
LIMS3
LIMS3-LOC440895 readthrough
LIM and senescent cell antigen-like domains 3-like
LIM and senescent cell antigen-like domains 3
chr12_-_76424474 0.806 PHLDA1
pleckstrin homology-like domain, family A, member 1
chr1_+_77747727 0.805 AK5
adenylate kinase 5
chr3_-_101231973 0.796 NM_001077203
NM_020654
SENP7

SUMO1/sentrin specific peptidase 7

chr2_-_110874142 0.796 NM_005434
MALL
mal, T-cell differentiation protein-like
chr16_-_4166021 0.793 ADCY9
adenylate cyclase 9
chr4_+_108852671 0.789 NM_183075
CYP2U1
cytochrome P450, family 2, subfamily U, polypeptide 1
chr6_+_31973358 0.787 NM_000500
NM_001128590
CYP21A2

cytochrome P450, family 21, subfamily A, polypeptide 2

chr20_+_34680569 0.785 EPB41L1
erythrocyte membrane protein band 4.1-like 1
chr2_+_110656008 0.781 NM_001205288
NM_033514
LIMS3-LOC440895
LIMS3L
LIMS3
LIMS3-LOC440895 readthrough
LIM and senescent cell antigen-like domains 3-like
LIM and senescent cell antigen-like domains 3
chr17_-_76124791 0.780 NM_001127198
TMC6
transmembrane channel-like 6
chrX_+_77166223 0.771 ATP7A
ATPase, Cu++ transporting, alpha polypeptide
chr11_-_124632050 0.768 NM_138961
ESAM
endothelial cell adhesion molecule
chrX_-_54521866 0.767 FGD1
FYVE, RhoGEF and PH domain containing 1
chr17_+_58677603 0.767 PPM1D
protein phosphatase, Mg2+/Mn2+ dependent, 1D
chr11_+_33563772 0.764 NM_012194
C11orf41
chromosome 11 open reading frame 41
chr8_+_97506071 0.763 SDC2
syndecan 2
chr2_-_197036301 0.760 NM_004226
STK17B
serine/threonine kinase 17b
chr17_+_61554420 0.758 NM_000789
ACE
angiotensin I converting enzyme (peptidyl-dipeptidase A) 1
chr8_+_56792345 0.747 NM_001111097
NM_002350
LYN

v-yes-1 Yamaguchi sarcoma viral related oncogene homolog

chr6_-_35696359 0.746 NM_001145775
FKBP5
FK506 binding protein 5
chr11_-_2018446 0.742 H19
H19, imprinted maternally expressed transcript (non-protein coding)
chr12_-_54813010 0.741 NM_002205
ITGA5
integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
chr17_-_76124767 0.736 TMC6
transmembrane channel-like 6
chr11_-_89322778 0.733 NM_001143837
NOX4
NADPH oxidase 4
chr11_+_7618416 0.733 PPFIBP2
PTPRF interacting protein, binding protein 2 (liprin beta 2)
chr2_+_189156395 0.726 NM_001252668
NM_001252669
NM_016315
GULP1


GULP, engulfment adaptor PTB domain containing 1


chr6_+_15246299 0.726 NM_004973
JARID2
jumonji, AT rich interactive domain 2
chr12_-_8043743 0.723 SLC2A14
solute carrier family 2 (facilitated glucose transporter), member 14
chrX_+_54835492 0.721 NM_201222
MAGED2
melanoma antigen family D, 2
chr10_+_102107001 0.720 SCD
stearoyl-CoA desaturase (delta-9-desaturase)
chr14_+_63671101 0.719 NM_020663
RHOJ
ras homolog gene family, member J
chr5_-_73936299 0.717 ENC1
ectodermal-neural cortex 1 (with BTB-like domain)
chrX_+_107069502 0.714 MID2
midline 2
chr3_+_150126705 0.713 NM_014779
TSC22D2
TSC22 domain family, member 2
chr14_-_23285011 0.710 NM_001126105
SLC7A7
solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
chr3_-_32023237 0.707 NM_001174060
NM_017784
OSBPL10

oxysterol binding protein-like 10

chr3_+_58223415 0.706 ABHD6
abhydrolase domain containing 6
chr11_-_66115016 0.706 NM_006876
B3GNT1
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 1
chr12_+_13349601 0.702 NM_001423
EMP1
epithelial membrane protein 1
chr12_-_124018428 0.702 RILPL1
Rab interacting lysosomal protein-like 1
chr15_+_63569748 0.701 NM_001145646
NM_031301
APH1B

anterior pharynx defective 1 homolog B (C. elegans)

chr6_+_37321719 0.700 NM_003958
NM_183078
RNF8

ring finger protein 8

chr13_+_58207858 0.699 PCDH17
protocadherin 17
chr10_-_103347978 0.698 NM_001174084
NM_001174085
NM_013274
POLL


polymerase (DNA directed), lambda


chrX_+_107069459 0.694 MID2
midline 2
chr10_+_94833646 0.694 NM_000783
CYP26A1
cytochrome P450, family 26, subfamily A, polypeptide 1
chr6_+_25279651 0.691 NM_001173977
NM_017640
LRRC16A

leucine rich repeat containing 16A

chr5_-_140013034 0.687 NM_000591
CD14
CD14 molecule
chr8_+_97506478 0.686 SDC2
syndecan 2

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.29 1.40e-03 GO:0006464 protein modification process
1.16 1.52e-02 GO:0051716 cellular response to stimulus
1.25 1.83e-02 GO:0043412 macromolecule modification
1.17 3.39e-02 GO:0023052 signaling

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.11 8.85e-05 GO:0005737 cytoplasm
1.39 1.42e-04 GO:0005783 endoplasmic reticulum
1.39 9.00e-03 GO:0044432 endoplasmic reticulum part
1.65 1.45e-02 GO:0000323 lytic vacuole
1.65 1.45e-02 GO:0005764 lysosome
1.58 2.58e-02 GO:0005773 vacuole
1.03 2.93e-02 GO:0044464 cell part
1.38 3.01e-02 GO:0042175 nuclear membrane-endoplasmic reticulum network
1.03 3.04e-02 GO:0005623 cell
1.24 3.29e-02 GO:0012505 endomembrane system
1.38 3.54e-02 GO:0005789 endoplasmic reticulum membrane

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.10 7.02e-03 GO:0005515 protein binding
4.21 1.73e-02 GO:0005001 transmembrane receptor protein tyrosine phosphatase activity
4.21 1.73e-02 GO:0019198 transmembrane receptor protein phosphatase activity