Motif ID: TFEB.p2

Z-value: 1.100


Transcription factors associated with TFEB.p2:

Gene SymbolEntrez IDGene Name
TFEB 7942 transcription factor EB

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.p-valuePlot
TFEBchr6_-_41702734,
chr6_-_41703938
0.301.5e-01Click!


Activity profile for motif TFEB.p2.

activity profile for motif TFEB.p2


Sorted Z-values histogram for motif TFEB.p2

Sorted Z-values for motif TFEB.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of TFEB.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr1_-_11866079 7.361 NM_005957
MTHFR
methylenetetrahydrofolate reductase (NAD(P)H)
chr7_-_27183225 4.889 NM_019102
HOXA5
homeobox A5
chrX_+_101975641 4.289 NM_001142524
NM_001142525
NM_001142526
NM_001142527
NM_001142528
NM_030639
BHLHB9





basic helix-loop-helix domain containing, class B, 9





chr17_-_46688362 3.852 NM_004502
HOXB7
homeobox B7
chr6_+_87865261 3.835 NM_015021
ZNF292
zinc finger protein 292
chr19_-_36545119 3.650 THAP8
THAP domain containing 8
chr20_-_39317875 3.617 NM_005461
MAFB
v-maf musculoaponeurotic fibrosarcoma oncogene homolog B (avian)
chr11_+_67159421 3.521 NM_004584
RAD9A
RAD9 homolog A (S. pombe)
chr10_-_105452878 3.467 SH3PXD2A
SH3 and PX domains 2A
chr11_+_7535213 3.426 PPFIBP2
PTPRF interacting protein, binding protein 2 (liprin beta 2)
chr17_-_47841517 3.337 NM_030802
FAM117A
family with sequence similarity 117, member A
chr3_-_122512526 3.254 NM_024610
HSPBAP1
HSPB (heat shock 27kDa) associated protein 1
chr5_-_172198160 3.232 NM_004417
DUSP1
dual specificity phosphatase 1
chr17_-_46688279 3.195 HOXB7
homeobox B7
chr1_-_11865963 3.120 MTHFR
methylenetetrahydrofolate reductase (NAD(P)H)
chr16_+_30960377 3.081 NM_152288
ORAI3
ORAI calcium release-activated calcium modulator 3
chr17_+_47866061 2.997 KAT7
K(lysine) acetyltransferase 7
chr7_-_27196163 2.985 NM_006896
HOXA7
homeobox A7
chr16_+_30960413 2.981 ORAI3
ORAI calcium release-activated calcium modulator 3
chr17_+_47865980 2.980 NM_001199155
NM_001199156
NM_001199157
NM_001199158
NM_007067
KAT7




K(lysine) acetyltransferase 7




chr5_+_172483285 2.952 NM_001168393
NM_001168394
NM_153607
C5orf41


chromosome 5 open reading frame 41


chr16_+_30960434 2.888 ORAI3
ORAI calcium release-activated calcium modulator 3
chr8_-_9009050 2.831 NM_001201329
PPP1R3B
protein phosphatase 1, regulatory subunit 3B
chr7_-_27205123 2.811 HOXA9
homeobox A9
chr14_+_38677186 2.791 NM_001049
SSTR1
somatostatin receptor 1
chr10_-_32217687 2.768 ARHGAP12
Rho GTPase activating protein 12
chr17_-_47841468 2.742 FAM117A
family with sequence similarity 117, member A
chr6_-_84937313 2.725 NM_014895
KIAA1009
KIAA1009
chr6_-_84418705 2.715 NM_001242792
SNAP91
synaptosomal-associated protein, 91kDa homolog (mouse)
chr10_-_93392857 2.680 NM_005398
PPP1R3C
protein phosphatase 1, regulatory subunit 3C
chr8_-_71581354 2.671 LACTB2
lactamase, beta 2
chr7_-_27205148 2.646 NM_152739
HOXA9
homeobox A9
chr10_-_64576123 2.643 NM_000399
NM_001136177
NM_001136179
EGR2


early growth response 2


chr19_-_36545298 2.632 THAP8
THAP domain containing 8
chr16_+_8806825 2.609 NM_000663
ABAT
4-aminobutyrate aminotransferase
chr3_+_112280871 2.608 NM_017945
SLC35A5
solute carrier family 35, member A5
chr17_-_48945338 2.575 NM_001243877
TOB1
transducer of ERBB2, 1
chr17_+_47866119 2.574 KAT7
K(lysine) acetyltransferase 7
chr7_-_27224762 2.556 NM_005523
HOXA11
homeobox A11
chr1_+_11866240 2.527 CLCN6
chloride channel 6
chr10_-_32217762 2.513 NM_018287
ARHGAP12
Rho GTPase activating protein 12
chr4_-_149363498 2.469 NM_000901
NM_001166104
NR3C2

nuclear receptor subfamily 3, group C, member 2

chr5_-_154230157 2.461 C5orf4
chromosome 5 open reading frame 4
chrX_+_118108575 2.448 LONRF3
LON peptidase N-terminal domain and ring finger 3
chr8_+_120220554 2.359 NM_052886
MAL2
mal, T-cell differentiation protein 2 (gene/pseudogene)
chr5_+_41904459 2.353 NM_175921
C5orf51
chromosome 5 open reading frame 51
chr2_+_148778573 2.344 NM_018328
MBD5
methyl-CpG binding domain protein 5
chr17_+_65821625 2.314 NM_004459
NM_182641
BPTF

bromodomain PHD finger transcription factor

chr5_-_154230212 2.277 NM_032385
C5orf4
chromosome 5 open reading frame 4
chr10_-_64576074 2.253 EGR2
early growth response 2
chr13_-_50159628 2.237 RCBTB1
regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1
chr8_-_71581419 2.237 NM_016027
LACTB2
lactamase, beta 2
chr17_-_35969401 2.216 NM_001163544
NM_001163545
NM_001163546
NM_001163547
NM_007247
NM_080550
NM_198882
SYNRG






synergin, gamma






chr1_-_154531083 2.203 NM_017582
UBE2Q1
ubiquitin-conjugating enzyme E2Q family member 1
chr14_-_54955664 2.178 GMFB
glia maturation factor, beta
chr13_-_49001042 2.124 NM_001162497
LPAR6
lysophosphatidic acid receptor 6
chr12_+_12878718 2.120 NM_001130415
APOLD1
apolipoprotein L domain containing 1
chr14_-_54955714 2.113 NM_004124
GMFB
glia maturation factor, beta
chrX_+_118108595 2.100 NM_001031855
NM_024778
LONRF3

LON peptidase N-terminal domain and ring finger 3

chr6_-_80656870 2.078 NM_022726
ELOVL4
ELOVL fatty acid elongase 4
chr17_-_7137675 2.074 DVL2
dishevelled, dsh homolog 2 (Drosophila)
chr11_+_118938528 2.048 VPS11
vacuolar protein sorting 11 homolog (S. cerevisiae)
chr17_-_46687925 2.044 HOXB7
homeobox B7
chr7_+_17338182 2.031 NM_001621
AHR
aryl hydrocarbon receptor
chr8_+_71581599 2.015 NM_001011720
XKR9
XK, Kell blood group complex subunit-related family, member 9
chr11_+_118938530 1.987 VPS11
vacuolar protein sorting 11 homolog (S. cerevisiae)
chr17_-_21156577 1.978 NM_152914
C17orf103
chromosome 17 open reading frame 103
chr11_+_118938515 1.972 VPS11
vacuolar protein sorting 11 homolog (S. cerevisiae)
chr11_-_27723061 1.967 NM_170733
BDNF
brain-derived neurotrophic factor
chr12_-_10021932 1.955 CLEC2B
C-type lectin domain family 2, member B
chr11_-_18343670 1.881 NM_007216
NM_181507
NM_181508
HPS5


Hermansky-Pudlak syndrome 5


chr2_+_220042986 1.869 FAM134A
family with sequence similarity 134, member A
chr8_-_103667882 1.843 NM_005655
KLF10
Kruppel-like factor 10
chr14_-_20929635 1.819 NM_001100814
NM_144568
TMEM55B

transmembrane protein 55B

chr10_+_46222647 1.803 NM_001169106
NM_001169107
NM_015262
FAM21C


family with sequence similarity 21, member C


chr3_+_112280911 1.790 SLC35A5
solute carrier family 35, member A5
chr10_-_50747080 1.788 NM_000124
ERCC6
PGBD3
excision repair cross-complementing rodent repair deficiency, complementation group 6
piggyBac transposable element derived 3
chr17_-_7137722 1.724 NM_004422
DVL2
dishevelled, dsh homolog 2 (Drosophila)
chr10_-_50747038 1.710 ERCC6
excision repair cross-complementing rodent repair deficiency, complementation group 6
chrX_+_149737019 1.709 NM_000252
MTM1
myotubularin 1
chr2_+_220042948 1.676 FAM134A
family with sequence similarity 134, member A
chr16_-_2097818 1.655 NM_002528
NTHL1
nth endonuclease III-like 1 (E. coli)
chr13_-_110438896 1.652 NM_003749
IRS2
insulin receptor substrate 2
chr17_-_62915580 1.651 LRRC37A3
leucine rich repeat containing 37, member A3
chr7_-_100808832 1.649 NM_003378
VGF
VGF nerve growth factor inducible
chr1_+_76540374 1.631 NM_001160011
NM_152996
ST6GALNAC3

ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3

chr8_-_126103926 1.631 KIAA0196
KIAA0196
chr1_+_66999805 1.622 NM_032291
SGIP1
SH3-domain GRB2-like (endophilin) interacting protein 1
chrX_+_149737083 1.616 MTM1
myotubularin 1
chr6_-_144329342 1.607 NM_001080952
NM_001080953
NM_001080954
NM_001080956
NM_002656
NM_006718
PLAGL1





HYMAI
pleiomorphic adenoma gene-like 1





hydatidiform mole associated and imprinted (non-protein coding)
chr9_-_126030854 1.597 NM_001171137
STRBP
spermatid perinuclear RNA binding protein
chr8_-_126104004 1.597 KIAA0196
KIAA0196
chr20_+_44520021 1.592 CTSA
cathepsin A
chr8_-_126104021 1.590 KIAA0196
KIAA0196
chr9_-_131709783 1.579 NM_014908
DOLK
dolichol kinase
chr2_-_105946104 1.538 NM_001142621
NM_004257
TGFBRAP1

transforming growth factor, beta receptor associated protein 1

chr9_-_126030792 1.532 NM_018387
STRBP
spermatid perinuclear RNA binding protein
chr8_-_126103873 1.517 KIAA0196
KIAA0196
chrX_+_102883891 1.514 NM_001006639
NM_004780
TCEAL1

transcription elongation factor A (SII)-like 1

chr3_-_126076057 1.513 NM_014079
KLF15
Kruppel-like factor 15
chr17_-_66951381 1.502 NM_007168
ABCA8
ATP-binding cassette, sub-family A (ABC1), member 8
chr2_-_238499317 1.499 RAB17
RAB17, member RAS oncogene family
chr6_+_7107986 1.487 NM_001003698
NM_001003699
NM_001003700
RREB1


ras responsive element binding protein 1


chr2_+_220042901 1.478 NM_024293
FAM134A
family with sequence similarity 134, member A
chr11_+_9595309 1.476 WEE1
WEE1 homolog (S. pombe)
chr1_-_154928595 1.464 PBXIP1
pre-B-cell leukemia homeobox interacting protein 1
chr2_+_109204745 1.456 NM_004987
LIMS1
LIM and senescent cell antigen-like domains 1
chr12_+_93964801 1.446 SOCS2
suppressor of cytokine signaling 2
chr11_+_18344113 1.428 GTF2H1
general transcription factor IIH, polypeptide 1, 62kDa
chr6_+_122720685 1.420 NM_001135564
NM_001243094
NM_004506
HSF2


heat shock transcription factor 2


chr12_+_12869818 1.419 NM_004064
CDKN1B
cyclin-dependent kinase inhibitor 1B (p27, Kip1)
chr16_-_23521755 1.405 GGA2
golgi-associated, gamma adaptin ear containing, ARF binding protein 2
chr1_+_11866206 1.392 NM_001286
NM_021735
NM_021736
NM_021737
CLCN6



chloride channel 6



chr6_+_122720750 1.390 HSF2
heat shock transcription factor 2
chr14_-_20929484 1.386 TMEM55B
transmembrane protein 55B
chrX_+_100663205 1.369 HNRNPH2
heterogeneous nuclear ribonucleoprotein H2 (H')
chr13_+_42846255 1.364 NM_016248
AKAP11
A kinase (PRKA) anchor protein 11
chrX_-_100548044 1.354 NM_024885
TAF7L
TAF7-like RNA polymerase II, TATA box binding protein (TBP)-associated factor, 50kDa
chr8_-_95274520 1.353 GEM
GTP binding protein overexpressed in skeletal muscle
chr8_-_126104045 1.349 NM_014846
KIAA0196
KIAA0196
chr10_+_51827654 1.348 NM_001005751
FAM21C
FAM21A
family with sequence similarity 21, member C
family with sequence similarity 21, member A
chr4_-_99850280 1.346 EIF4E
eukaryotic translation initiation factor 4E
chr11_+_9595183 1.333 NM_003390
WEE1
WEE1 homolog (S. pombe)
chr11_+_118938473 1.332 NM_021729
VPS11
vacuolar protein sorting 11 homolog (S. cerevisiae)
chr5_+_122110762 1.328 SNX2
sorting nexin 2
chrX_+_77166178 1.319 NM_000052
ATP7A
ATPase, Cu++ transporting, alpha polypeptide
chr10_+_51827710 1.313 FAM21A
family with sequence similarity 21, member A
chr12_+_122064448 1.286 NM_032790
ORAI1
ORAI calcium release-activated calcium modulator 1
chr6_-_158589289 1.282 NM_032861
SERAC1
serine active site containing 1
chrX_-_106960268 1.271 NM_004089
TSC22D3
TSC22 domain family, member 3
chr2_+_233562031 1.260 GIGYF2
GRB10 interacting GYF protein 2
chr19_-_41256371 1.244 C19orf54
chromosome 19 open reading frame 54
chr5_-_55529185 1.241 NM_024669
ANKRD55
ankyrin repeat domain 55
chr16_-_67184822 1.232 NM_033309
B3GNT9
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 9
chr12_-_122750954 1.226 VPS33A
vacuolar protein sorting 33 homolog A (S. cerevisiae)
chr19_+_35760002 1.214 USF2
upstream transcription factor 2, c-fos interacting
chr8_-_95274540 1.211 NM_005261
NM_181702
GEM

GTP binding protein overexpressed in skeletal muscle

chr8_+_74903563 1.210 NM_001195797
NM_015364
LY96

lymphocyte antigen 96

chr5_+_122110778 1.208 SNX2
sorting nexin 2
chr5_+_131892556 1.203 NM_005732
RAD50
RAD50 homolog (S. cerevisiae)
chr12_+_2986361 1.194 NM_001252499
NM_001252500
C12orf32

chromosome 12 open reading frame 32

chr1_+_10092990 1.192 NM_001105562
NM_006048
UBE4B

ubiquitination factor E4B

chr7_+_155089614 1.188 INSIG1
insulin induced gene 1
chr5_+_122110737 1.188 NM_003100
SNX2
sorting nexin 2
chrX_+_77166223 1.186 ATP7A
ATPase, Cu++ transporting, alpha polypeptide
chr11_+_9595451 1.186 WEE1
WEE1 homolog (S. pombe)
chr4_-_76439479 1.181 RCHY1
ring finger and CHY zinc finger domain containing 1
chr11_+_9595429 1.177 WEE1
WEE1 homolog (S. pombe)
chr16_+_5083671 1.174 LOC100507589
uncharacterized LOC100507589
chr4_+_1340957 1.169 NM_020894
KIAA1530
KIAA1530
chr18_-_46987016 1.166 NM_017653
DYM
dymeclin
chr1_-_154928564 1.165 NM_020524
PBXIP1
pre-B-cell leukemia homeobox interacting protein 1
chr2_+_177053306 1.156 NM_024501
HOXD1
homeobox D1
chr6_-_151773168 1.150 NM_017909
RMND1
required for meiotic nuclear division 1 homolog (S. cerevisiae)
chr7_+_27225009 1.147 HOXA11-AS1
HOXA11 antisense RNA 1 (non-protein coding)
chr14_-_39901619 1.143 NM_203301
FBXO33
F-box protein 33
chrX_-_34675366 1.127 NM_031442
TMEM47
transmembrane protein 47
chr8_-_54755821 1.125 ATP6V1H
ATPase, H+ transporting, lysosomal 50/57kDa, V1 subunit H
chr5_-_141392537 1.115 NM_005471
GNPDA1
glucosamine-6-phosphate deaminase 1
chr8_-_54755546 1.111 NM_213620
ATP6V1H
ATPase, H+ transporting, lysosomal 50/57kDa, V1 subunit H
chr6_-_31865455 1.107 NM_006709
NM_025256
EHMT2

euchromatic histone-lysine N-methyltransferase 2

chr3_-_4508955 1.103 NM_001164674
NM_001164675
NM_182760
SUMF1


sulfatase modifying factor 1


chr3_+_158519888 1.099 MFSD1
major facilitator superfamily domain containing 1
chr8_-_126104007 1.081 KIAA0196
KIAA0196
chr3_-_134204809 1.078 NM_001242375
ANAPC13
anaphase promoting complex subunit 13
chr17_-_1733083 1.076 NM_052928
SMYD4
SET and MYND domain containing 4
chr2_-_183903225 1.076 NM_013436
NM_205842
NCKAP1

NCK-associated protein 1

chr6_+_64345726 1.070 PHF3
PHD finger protein 3
chr11_+_7535000 1.063 NM_003621
PPFIBP2
PTPRF interacting protein, binding protein 2 (liprin beta 2)
chr8_-_54755836 1.061 NM_015941
NM_213619
ATP6V1H

ATPase, H+ transporting, lysosomal 50/57kDa, V1 subunit H

chr2_+_109204777 1.060 LIMS1
LIM and senescent cell antigen-like domains 1
chr17_-_38256905 1.058 NM_021724
NR1D1
nuclear receptor subfamily 1, group D, member 1
chr19_-_17375522 1.058 NM_031941
USHBP1
Usher syndrome 1C binding protein 1
chr2_+_176987412 1.056 NM_014213
HOXD9
homeobox D9
chr11_-_57283145 1.051 NM_003627
SLC43A1
solute carrier family 43, member 1
chr3_-_134204840 1.047 NM_015391
NM_001242374
ANAPC13

anaphase promoting complex subunit 13

chr7_-_30029284 1.045 NM_001145515
NM_014766
NM_001145513
SCRN1


secernin 1


chr12_+_72233486 1.045 NM_001146213
NM_001146214
NM_022771
TBC1D15


TBC1 domain family, member 15


chr3_+_158519911 1.043 MFSD1
major facilitator superfamily domain containing 1
chr16_-_70719854 1.036 NM_138383
MTSS1L
metastasis suppressor 1-like
chr6_+_42018250 1.031 NM_138572
TAF8
TAF8 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 43kDa
chr6_+_123110345 1.026 SMPDL3A
sphingomyelin phosphodiesterase, acid-like 3A
chr1_-_28969516 1.021 NM_001135218
NM_005644
TAF12

TAF12 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 20kDa

chr13_-_52027133 1.015 INTS6
integrator complex subunit 6
chr10_-_46090191 1.015 NM_001002265
NM_145021
MARCH8

membrane-associated ring finger (C3HC4) 8

chr17_-_57184114 1.004 TRIM37
tripartite motif containing 37
chr11_+_9685650 0.999 SWAP70
SWAP switching B-cell complex 70kDa subunit
chr14_+_74551655 0.999 NM_001024674
LIN52
lin-52 homolog (C. elegans)
chr3_-_4508939 0.996 SUMF1
sulfatase modifying factor 1
chr2_+_233561997 0.995 NM_001103146
NM_001103147
NM_001103148
NM_015575
GIGYF2



GRB10 interacting GYF protein 2



chr4_-_47465719 0.988 COMMD8
COMM domain containing 8
chr2_-_62733475 0.977 NM_198276
TMEM17
transmembrane protein 17
chr7_-_14031049 0.970 NM_001163148
ETV1
ets variant 1
chr17_+_30677187 0.960 ZNF207
zinc finger protein 207
chr4_-_76439582 0.953 NM_001008925
NM_001009922
NM_015436
RCHY1


ring finger and CHY zinc finger domain containing 1


chr12_-_110434187 0.947 NM_001135213
NM_001135214
NM_014776
NM_057169
NM_057170
NM_139201
GIT2





G protein-coupled receptor kinase interacting ArfGAP 2





chr8_-_82754427 0.942 NM_022133
NM_152836
NM_152837
SNX16


sorting nexin 16


chr11_+_9685624 0.940 NM_015055
SWAP70
SWAP switching B-cell complex 70kDa subunit
chr16_-_71318761 0.935 FTSJD1
FtsJ methyltransferase domain containing 1
chr17_+_42977141 0.934 NM_213607
CCDC103
coiled-coil domain containing 103

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
6.97 6.91e-07 GO:0007033 vacuole organization
7.74 4.69e-04 GO:0007040 lysosome organization
4.69 5.27e-03 GO:0048704 embryonic skeletal system morphogenesis
3.97 8.40e-03 GO:0048706 embryonic skeletal system development
14.93 9.35e-03 GO:0021546 rhombomere development
20.90 1.01e-02 GO:0021569 rhombomere 3 development
3.18 1.49e-02 GO:0048705 skeletal system morphogenesis
2.45 4.64e-02 GO:0003002 regionalization

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
3.33 3.43e-11 GO:0005773 vacuole
3.28 5.53e-09 GO:0000323 lytic vacuole
3.28 5.53e-09 GO:0005764 lysosome
1.13 7.75e-05 GO:0044424 intracellular part
1.12 9.18e-05 GO:0005622 intracellular
1.18 1.21e-04 GO:0043231 intracellular membrane-bounded organelle
3.22 1.32e-04 GO:0044437 vacuolar part
1.18 1.42e-04 GO:0043227 membrane-bounded organelle
1.16 1.74e-04 GO:0043229 intracellular organelle
1.15 2.29e-04 GO:0043226 organelle
3.09 8.04e-04 GO:0005774 vacuolar membrane
1.23 8.13e-04 GO:0044444 cytoplasmic part
1.23 3.75e-03 GO:0044446 intracellular organelle part
1.55 6.07e-03 GO:0005654 nucleoplasm
1.22 6.79e-03 GO:0044422 organelle part
3.12 9.60e-03 GO:0005765 lysosomal membrane
3.04 1.35e-02 GO:0005770 late endosome
1.15 1.84e-02 GO:0005737 cytoplasm
2.29 1.86e-02 GO:0010008 endosome membrane
2.27 2.13e-02 GO:0044440 endosomal part

Gene overrepresentation in function category:

enrichment   p-value GO term description
3.01 3.31e-02 GO:0016798 hydrolase activity, acting on glycosyl bonds