Motif ID: VSX1,2.p2

Z-value: 0.443


Transcription factors associated with VSX1,2.p2:

Gene SymbolEntrez IDGene Name
VSX1 30813 visual system homeobox 1
VSX2 338917 visual system homeobox 2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.p-valuePlot
VSX1chr20_-_250627560.262.0e-01Click!


Activity profile for motif VSX1,2.p2.

activity profile for motif VSX1,2.p2


Sorted Z-values histogram for motif VSX1,2.p2

Sorted Z-values for motif VSX1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of VSX1,2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr1_-_150738232 1.885 CTSS
cathepsin S
chr11_-_4414887 1.587 NM_003141
TRIM21
tripartite motif containing 21
chr4_-_122137781 1.272 NM_001128843
TNIP3
TNFAIP3 interacting protein 3
chr6_+_127898318 1.211 NM_001010905
C6orf58
chromosome 6 open reading frame 58
chr15_-_55563091 0.903 NM_183236
RAB27A
RAB27A, member RAS oncogene family
chr8_-_10512616 0.755 NM_178857
RP1L1
retinitis pigmentosa 1-like 1
chr1_-_205325915 0.420 NM_018203
KLHDC8A
kelch domain containing 8A
chr4_-_39979159 0.401 PDS5A
PDS5, regulator of cohesion maintenance, homolog A (S. cerevisiae)
chr11_-_57417247 0.390 NM_145008
YPEL4
yippee-like 4 (Drosophila)
chr4_+_169418167 0.376 NM_001166108
NM_016081
PALLD

palladin, cytoskeletal associated protein

chr6_+_64231626 0.374 PTP4A1
protein tyrosine phosphatase type IVA, member 1
chr7_-_83824216 0.337 NM_006080
SEMA3A
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A
chr15_-_55562483 0.317 NM_183234
NM_004580
RAB27A

RAB27A, member RAS oncogene family

chr21_-_35899046 0.299 NM_203418
RCAN1
regulator of calcineurin 1
chr3_+_121774208 0.281 NM_001206924
NM_001206925
NM_175862
CD86


CD86 molecule


chr15_+_100173182 0.271 NM_001130928
MEF2A
myocyte enhancer factor 2A
chr4_+_78432905 0.260 NM_006419
CXCL13
chemokine (C-X-C motif) ligand 13
chr1_-_173174611 0.259 TNFSF4
tumor necrosis factor (ligand) superfamily, member 4
chr9_+_132897342 0.248 GPR107
G protein-coupled receptor 107
chr3_-_157213138 0.242 NM_001167917
VEPH1
ventricular zone expressed PH domain homolog 1 (zebrafish)
chr6_-_46293628 0.240 NM_005822
RCAN2
regulator of calcineurin 2
chr3_+_188664939 0.235 TPRG1
tumor protein p63 regulated 1
chr1_+_160160284 0.233 NM_001231
CASQ1
calsequestrin 1 (fast-twitch, skeletal muscle)
chr4_-_39979549 0.226 NM_001100399
NM_001100400
PDS5A

PDS5, regulator of cohesion maintenance, homolog A (S. cerevisiae)

chr18_+_61554938 0.225 NM_001143818
NM_002575
SERPINB2

serpin peptidase inhibitor, clade B (ovalbumin), member 2

chr10_-_56560947 0.223 NM_001142763
NM_001142764
NM_001142765
NM_001142766
NM_001142767
NM_001142768
NM_001142769
NM_001142770
NM_001142771
NM_001142772
NM_001142773
NM_033056
PCDH15











protocadherin-related 15











chr1_+_28585959 0.219 NM_031459
SESN2
sestrin 2
chr2_-_175712276 0.210 NM_001206602
CHN1
chimerin (chimaerin) 1
chr8_+_92261515 0.198 NM_052832
NM_134266
SLC26A7

solute carrier family 26, member 7

chr3_-_25683825 0.192 TOP2B
topoisomerase (DNA) II beta 180kDa
chr8_+_54764367 0.192 NM_170587
RGS20
regulator of G-protein signaling 20
chr10_-_70066594 0.183 PBLD
phenazine biosynthesis-like protein domain containing
chr6_-_47253962 0.177 TNFRSF21
tumor necrosis factor receptor superfamily, member 21
chr1_+_101003692 0.170 NM_022049
GPR88
G protein-coupled receptor 88
chrX_+_108779009 0.166 NM_018698
NXT2
nuclear transport factor 2-like export factor 2
chr3_-_157221362 0.165 NM_001167915
NM_001167916
VEPH1

ventricular zone expressed PH domain homolog 1 (zebrafish)

chr10_-_92681025 0.159 NM_014391
ANKRD1
ankyrin repeat domain 1 (cardiac muscle)
chr3_+_181417387 0.158 SOX2-OT
SOX2 overlapping transcript (non-protein coding)
chr11_+_17741109 0.157 NM_002478
MYOD1
myogenic differentiation 1
chr10_+_18549583 0.157 NM_000724
CACNB2
calcium channel, voltage-dependent, beta 2 subunit
chr1_+_244515936 0.156 NM_001012970
C1orf100
chromosome 1 open reading frame 100
chr4_-_169239816 0.154 NM_017631
DDX60
DEAD (Asp-Glu-Ala-Asp) box polypeptide 60
chr10_+_126630691 0.152 NM_017580
ZRANB1
zinc finger, RAN-binding domain containing 1
chr4_-_76878558 0.149 SDAD1
SDA1 domain containing 1
chr5_+_126984712 0.143 NM_001048252
CTXN3
cortexin 3
chr3_-_108248168 0.143 NM_014981
MYH15
myosin, heavy chain 15
chr14_+_67831484 0.136 EIF2S1
eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa
chr4_+_88571453 0.135 NM_001079911
NM_004407
DMP1

dentin matrix acidic phosphoprotein 1

chr12_-_4488707 0.134 NM_020638
FGF23
fibroblast growth factor 23
chr8_+_67039130 0.134 NM_033058
NM_184085
NM_184086
NM_184087
TRIM55



tripartite motif containing 55



chr4_+_70796798 0.131 NM_001025104
NM_001890
CSN1S1

casein alpha s1

chr16_-_67977956 0.124 NM_000229
LCAT
lecithin-cholesterol acyltransferase
chr1_-_155649597 0.120 NM_001198899
YY1AP1
YY1 associated protein 1
chr2_-_217560247 0.119 NM_000599
IGFBP5
insulin-like growth factor binding protein 5
chr18_-_30352841 0.119 NM_020805
KLHL14
kelch-like 14 (Drosophila)
chr12_-_91505215 0.117 LUM
lumican
chr5_+_71403040 0.114 NM_005909
MAP1B
microtubule-associated protein 1B
chr11_-_120008801 0.109 TRIM29
tripartite motif containing 29
chr10_+_96443250 0.106 NM_000772
NM_001128925
CYP2C18

cytochrome P450, family 2, subfamily C, polypeptide 18

chr4_-_123377471 0.104 NM_000586
IL2
interleukin 2
chr2_-_80530943 0.104 LRRTM1
leucine rich repeat transmembrane neuronal 1
chr8_-_52721903 0.100 NM_144651
PXDNL
peroxidasin homolog (Drosophila)-like
chr11_+_60163486 0.099 NM_001079692
NM_032597
MS4A14

membrane-spanning 4-domains, subfamily A, member 14

chr1_+_179560747 0.093 NM_001199091
NM_001199085
NM_173533
TDRD5


tudor domain containing 5


chr14_+_32798478 0.093 NM_004274
AKAP6
A kinase (PRKA) anchor protein 6
chr17_+_39261640 0.091 NM_001146041
KRTAP4-9
keratin associated protein 4-9
chr12_-_52604488 0.090 NM_001242696
LOC283403
uncharacterized LOC283403
chr16_+_6823809 0.089 NM_001142334
RBFOX1
RNA binding protein, fox-1 homolog (C. elegans) 1
chr11_-_129062092 0.089 NM_001142685
ARHGAP32
Rho GTPase activating protein 32
chr7_-_81399286 0.087 NM_000601
NM_001010931
NM_001010932
NM_001010933
NM_001010934
HGF




hepatocyte growth factor (hepapoietin A; scatter factor)




chr3_+_111717585 0.086 NM_001008272
NM_013259
TAGLN3

transgelin 3

chr16_+_49407807 0.086 NM_144602
C16orf78
chromosome 16 open reading frame 78
chr15_-_42448769 0.085 NM_213600
PLA2G4F
phospholipase A2, group IVF
chr10_+_24755459 0.084 KIAA1217
KIAA1217
chr11_+_59824054 0.083 NM_001031666
NM_001031809
NM_006138
MS4A3


membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific)


chr2_-_99871569 0.083 NM_175735
LYG2
lysozyme G-like 2
chr1_-_200377262 0.082 ZNF281
zinc finger protein 281
chr16_+_12058963 0.081 NM_001192
TNFRSF17
tumor necrosis factor receptor superfamily, member 17
chr11_-_114466471 0.079 NM_001077639
NM_017678
FAM55D

family with sequence similarity 55, member D

chrX_+_107288199 0.078 NM_001170553
NM_182607
VSIG1

V-set and immunoglobulin domain containing 1

chr2_-_190927321 0.075 NM_005259
MSTN
myostatin
chr12_+_93096618 0.074 NM_001037671
NM_001178097
C12orf74

chromosome 12 open reading frame 74

chr20_-_52199635 0.073 NM_006526
ZNF217
zinc finger protein 217
chr16_+_4382224 0.071 NM_032575
GLIS2
GLIS family zinc finger 2
chr3_-_101039403 0.069 NM_016247
IMPG2
interphotoreceptor matrix proteoglycan 2
chr10_-_69455926 0.068 NM_013266
CTNNA3
catenin (cadherin-associated protein), alpha 3
chr6_+_160542862 0.067 NM_003057
NM_153187
SLC22A1

solute carrier family 22 (organic cation transporter), member 1

chr11_-_124190092 0.067 NM_001002918
OR8D2
olfactory receptor, family 8, subfamily D, member 2
chr6_+_155538096 0.065 NM_001010927
TIAM2
T-cell lymphoma invasion and metastasis 2
chr11_-_128894008 0.063 NM_014715
ARHGAP32
Rho GTPase activating protein 32
chr6_+_132859426 0.061 NM_175057
TAAR9
trace amine associated receptor 9 (gene/pseudogene)
chr12_-_53012332 0.060 NM_175068
KRT73
keratin 73
chr9_-_215892 0.058 NM_152569
C9orf66
chromosome 9 open reading frame 66
chrX_-_21676416 0.056 NM_153270
KLHL34
kelch-like 34 (Drosophila)
chr1_-_152386727 0.055 NM_016190
CRNN
cornulin
chrX_-_151619669 0.053 NM_000808
GABRA3
gamma-aminobutyric acid (GABA) A receptor, alpha 3
chr11_+_60048013 0.052 NM_001243266
NM_024021
NM_148975
MS4A4A


membrane-spanning 4-domains, subfamily A, member 4


chr12_-_53730003 0.052 NM_001173467
SP7
Sp7 transcription factor
chr9_-_4666665 0.051 NM_001039395
C9orf68
chromosome 9 open reading frame 68
chr8_-_87755880 0.050 NM_019098
CNGB3
cyclic nucleotide gated channel beta 3
chr2_-_80531716 0.050 LRRTM1
leucine rich repeat transmembrane neuronal 1
chr3_+_155838336 0.049 NM_172160
KCNAB1
potassium voltage-gated channel, shaker-related subfamily, beta member 1
chr19_-_7698569 0.047 NM_174895
PCP2
Purkinje cell protein 2
chr12_-_25150372 0.046 NM_001101339
C12orf77
chromosome 12 open reading frame 77
chr7_-_25268057 0.042 NM_022150
NPVF
neuropeptide VF precursor
chr10_+_18689512 0.039 NM_201570
CACNB2
calcium channel, voltage-dependent, beta 2 subunit
chr10_+_24755440 0.039 KIAA1217
KIAA1217
chr4_+_119809978 0.038 NM_001128933
NM_001128934
NM_133477
SYNPO2


synaptopodin 2


chr6_+_29079586 0.036 NM_001005216
OR2J3
olfactory receptor, family 2, subfamily J, member 3
chr12_-_52828105 0.036 NM_004693
KRT75
keratin 75
chr10_+_32856650 0.036 NM_024688
C10orf68
chromosome 10 open reading frame 68
chr16_+_31271311 0.036 ITGAM
integrin, alpha M (complement component 3 receptor 3 subunit)
chr1_+_28261503 0.035 NM_001009568
NM_014474
SMPDL3B

sphingomyelin phosphodiesterase, acid-like 3B

chr1_+_147425566 0.034 NM_001097616
GPR89C
G protein-coupled receptor 89C
chrX_+_70765479 0.032 OGT
O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase)
chr2_-_37374948 0.032 NM_001135652
EIF2AK2
eukaryotic translation initiation factor 2-alpha kinase 2
chr17_-_29624249 0.031 NM_002544
OMG
oligodendrocyte myelin glycoprotein
chr22_+_23154240 0.030


chr3_+_108855560 0.030 FLJ22763
uncharacterized LOC401081
chr7_-_135613197 0.029 LUZP6
leucine zipper protein 6
chr16_-_73092533 0.028 NM_001164766
ZFHX3
zinc finger homeobox 3
chr19_+_4769144 0.027 MIR7-3HG
MIR7-3 host gene (non-protein coding)
chr3_+_69985750 0.027 NM_000248
NM_001184968
NM_198158
NM_198178
MITF



microphthalmia-associated transcription factor



chr2_-_65159566 0.027 LOC400958
uncharacterized LOC400958
chr17_-_38911524 0.027 NM_181534
KRT25
keratin 25
chr22_+_41957011 0.027 NM_014460
CSDC2
cold shock domain containing C2, RNA binding
chr11_+_59824129 0.026 MS4A3
membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific)
chr1_-_151431648 0.026 POGZ
pogo transposable element with ZNF domain
chr11_+_45115563 0.025 NM_020229
PRDM11
PR domain containing 11
chr3_-_167191808 0.025 NM_006217
SERPINI2
serpin peptidase inhibitor, clade I (pancpin), member 2
chr1_+_117544371 0.024 NM_004258
CD101
CD101 molecule
chr9_+_66457288 0.024


chr11_-_128737132 0.024 NM_153764
NM_153765
NM_153766
NM_153767
KCNJ1



potassium inwardly-rectifying channel, subfamily J, member 1



chr14_-_95236351 0.024 NM_173849
GSC
goosecoid homeobox
chr7_+_129008044 0.024 AHCYL2
adenosylhomocysteinase-like 2
chr4_-_66536182 0.023 EPHA5
EPH receptor A5
chr9_+_116356199 0.022 NM_144489
RGS3
regulator of G-protein signaling 3
chr15_-_42749710 0.021 NM_022473
ZFP106
zinc finger protein 106 homolog (mouse)
chr12_-_57328044 0.021 NM_148897
SDR9C7
short chain dehydrogenase/reductase family 9C, member 7
chr3_+_115342302 0.021 GAP43
growth associated protein 43
chr12_-_58135853 0.020 NM_014770
AGAP2
ArfGAP with GTPase domain, ankyrin repeat and PH domain 2
chr7_+_114066554 0.020 NM_001172767
NM_148899
FOXP2

forkhead box P2

chr20_+_58571416 0.019 NM_021810
CDH26
cadherin 26
chrX_-_23925947 0.018 NM_024122
APOO
apolipoprotein O
chr10_-_98321823 0.015 TM9SF3
transmembrane 9 superfamily member 3
chr2_+_29038862 0.015 NM_001008779
SPDYA
speedy homolog A (Xenopus laevis)
chr5_-_96478438 0.015 LIX1
Lix1 homolog (chicken)
chr6_+_105404922 0.014 NM_001004317
LIN28B
lin-28 homolog B (C. elegans)
chr2_+_202671197 0.014 NM_139158
CDK15
cyclin-dependent kinase 15
chr4_+_74301932 0.014 NM_001134
AFP
alpha-fetoprotein
chr7_-_87342569 0.012 NM_000927
ABCB1
ATP-binding cassette, sub-family B (MDR/TAP), member 1
chr10_+_95372344 0.012 NM_006204
PDE6C
phosphodiesterase 6C, cGMP-specific, cone, alpha prime
chr7_+_102023016 0.012


chr11_-_120008738 0.012 TRIM29
tripartite motif containing 29
chr12_+_105153258 0.012 CHST11
carbohydrate (chondroitin 4) sulfotransferase 11
chr6_-_87804773 0.012 NM_000735
NM_001252383
CGA

glycoprotein hormones, alpha polypeptide

chr11_+_6897855 0.011 NM_207186
OR10A4
olfactory receptor, family 10, subfamily A, member 4
chr6_+_27925018 0.011 NM_012367
OR2B6
olfactory receptor, family 2, subfamily B, member 6
chr10_-_52645430 0.010 NM_001198818
NM_001198819
NM_001198820
NM_014576
NM_138932
NM_138933
A1CF





APOBEC1 complementation factor





chr2_-_80531486 0.009 NM_178839
LRRTM1
leucine rich repeat transmembrane neuronal 1
chr8_+_19796581 0.009 NM_000237
LPL
lipoprotein lipase
chr16_-_20338808 0.008 NM_001007240
NM_001007241
NM_001007242
NM_001502
GP2



glycoprotein 2 (zymogen granule membrane)



chrX_+_79675945 0.007 NM_152630
FAM46D
family with sequence similarity 46, member D
chr13_-_41593405 0.006 ELF1
E74-like factor 1 (ets domain transcription factor)
chr9_+_90497740 0.006 NM_178828
C9orf79
chromosome 9 open reading frame 79
chr18_-_51690988 0.006 MBD2
methyl-CpG binding domain protein 2
chr6_+_49467670 0.005 NM_001010904
GLYATL3
glycine-N-acyltransferase-like 3
chr11_-_16497917 0.004 NM_033326
SOX6
SRY (sex determining region Y)-box 6
chr7_-_44580857 0.004 NM_001101648
NM_013389
NPC1L1

NPC1 (Niemann-Pick disease, type C1, gene)-like 1

chr11_+_55578842 0.004 NM_001004738
OR5L1
olfactory receptor, family 5, subfamily L, member 1
chr11_-_114466397 0.003 FAM55D
family with sequence similarity 55, member D
chr4_-_72649734 0.003 NM_000583
GC
group-specific component (vitamin D binding protein)
chr3_-_164796275 0.002 NM_001041
SI
sucrase-isomaltase (alpha-glucosidase)
chr7_+_50348255 0.001 IKZF1
IKAROS family zinc finger 1 (Ikaros)

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
6.66 1.64e-03 GO:0007517 muscle organ development

Nothing significant found in compartment category.

Nothing significant found in function category.