Motif ID: ZEB1.p2

Z-value: 1.052


Transcription factors associated with ZEB1.p2:

Gene SymbolEntrez IDGene Name
ZEB1 6935 zinc finger E-box binding homeobox 1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.p-valuePlot
ZEB1chr10_+_316080970.087.1e-01Click!


Activity profile for motif ZEB1.p2.

activity profile for motif ZEB1.p2


Sorted Z-values histogram for motif ZEB1.p2

Sorted Z-values for motif ZEB1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of ZEB1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr21_+_46293925 3.500


chr17_-_31204071 3.038 MYO1D
myosin ID
chr7_-_22396511 2.919 NM_012294
RAPGEF5
Rap guanine nucleotide exchange factor (GEF) 5
chr19_+_10381763 2.250 ICAM1
intercellular adhesion molecule 1
chr19_+_38755238 2.182 SPINT2
serine peptidase inhibitor, Kunitz type, 2
chr19_+_38755097 2.159 NM_001166103
NM_021102
SPINT2

serine peptidase inhibitor, Kunitz type, 2

chr19_+_38755422 2.081 SPINT2
serine peptidase inhibitor, Kunitz type, 2
chr15_+_67358194 1.721 NM_005902
SMAD3
SMAD family member 3
chr1_-_209979388 1.622 NM_001206696
NM_006147
IRF6

interferon regulatory factor 6

chr14_-_51134862 1.438 SAV1
salvador homolog 1 (Drosophila)
chr14_-_51135021 1.431 NM_021818
SAV1
salvador homolog 1 (Drosophila)
chr1_-_95007139 1.413 NM_001178096
NM_001993
F3

coagulation factor III (thromboplastin, tissue factor)

chr1_+_37940180 1.338 ZC3H12A
zinc finger CCCH-type containing 12A
chr19_-_50432731 1.324 NUP62
nucleoporin 62kDa
chr1_+_37940129 1.276 ZC3H12A
zinc finger CCCH-type containing 12A
chr1_+_37940074 1.229 NM_025079
ZC3H12A
zinc finger CCCH-type containing 12A
chr16_+_84733606 1.218 USP10
ubiquitin specific peptidase 10
chr18_+_59992519 1.200 NM_003839
TNFRSF11A
tumor necrosis factor receptor superfamily, member 11a, NFKB activator
chr3_+_30648372 1.168 TGFBR2
transforming growth factor, beta receptor II (70/80kDa)
chr5_+_139028483 1.166 CXXC5
CXXC finger protein 5
chr2_-_28113954 1.119 LOC100302650
uncharacterized LOC100302650
chr5_+_139027868 1.108 CXXC5
CXXC finger protein 5
chr6_-_10419786 1.081 NM_001042425
TFAP2A
transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
chr5_+_139027907 1.080 CXXC5
CXXC finger protein 5
chr19_+_10381516 1.073 NM_000201
ICAM1
intercellular adhesion molecule 1
chr5_-_1112106 1.067 NM_006598
SLC12A7
solute carrier family 12 (potassium/chloride transporters), member 7
chr22_-_43089856 1.047 A4GALT
alpha 1,4-galactosyltransferase
chr1_+_65991390 1.046 LEPR
leptin receptor
chr5_+_139027955 1.041 CXXC5
CXXC finger protein 5
chr1_-_27339448 1.034 FAM46B
family with sequence similarity 46, member B
chr5_+_76114881 1.016 F2RL1
coagulation factor II (thrombin) receptor-like 1
chr3_+_39851028 0.995 NM_015460
MYRIP
myosin VIIA and Rab interacting protein
chr13_-_107187312 0.991 NM_004093
EFNB2
ephrin-B2
chr4_+_156588811 0.989 NM_001130684
GUCY1A3
guanylate cyclase 1, soluble, alpha 3
chr8_+_17354562 0.980 NM_001008539
SLC7A2
solute carrier family 7 (cationic amino acid transporter, y+ system), member 2
chr3_-_182833859 0.955 MCCC1
methylcrotonoyl-CoA carboxylase 1 (alpha)
chr21_+_26934440 0.954 MIR155HG
MIR155 host gene (non-protein coding)
chr7_-_50518021 0.944 NM_001042762
NM_022116
FIGNL1

fidgetin-like 1

chr14_-_61748193 0.928


chr6_-_159240398 0.928 EZR
ezrin
chr17_-_73874056 0.920 TRIM47
tripartite motif containing 47
chr2_+_46524901 0.917 EPAS1
endothelial PAS domain protein 1
chr4_+_2420671 0.907 NM_001193282
LOC402160
uncharacterized LOC402160
chr8_-_48650683 0.862 CEBPD
CCAAT/enhancer binding protein (C/EBP), delta
chr5_+_139028025 0.859 NM_016463
CXXC5
CXXC finger protein 5
chr19_+_39903749 0.858 NM_022835
PLEKHG2
pleckstrin homology domain containing, family G (with RhoGef domain) member 2
chr11_-_2018703 0.847 H19
H19, imprinted maternally expressed transcript (non-protein coding)
chr17_+_4402128 0.846 NM_001124758
SPNS2
spinster homolog 2 (Drosophila)
chr6_-_159240399 0.837 EZR
ezrin
chr7_+_150065330 0.829 REPIN1
replication initiator 1
chr5_+_76114832 0.828 NM_005242
F2RL1
coagulation factor II (thrombin) receptor-like 1
chr21_-_33984657 0.808 C21orf59
chromosome 21 open reading frame 59
chr1_-_41328002 0.805 NM_133467
CITED4
Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 4
chr1_+_89990396 0.792 NM_001134476
LRRC8B
leucine rich repeat containing 8 family, member B
chr21_+_37507209 0.789 NM_001236
CBR3
carbonyl reductase 3
chr3_+_53195214 0.787 NM_006254
NM_212539
PRKCD

protein kinase C, delta

chr1_-_41328019 0.784 CITED4
Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 4
chr22_+_50354139 0.783 NM_001001852
PIM3
pim-3 oncogene
chr11_-_119234628 0.773 USP2
ubiquitin specific peptidase 2
chr2_+_111878450 0.771 NM_001204106
NM_001204107
NM_001204108
NM_001204109
NM_001204110
NM_001204111
NM_001204112
NM_001204113
NM_006538
NM_138621
NM_138622
NM_138623
NM_138624
NM_138625
NM_138626
NM_138627
NM_207002
NM_207003
BCL2L11

















BCL2-like 11 (apoptosis facilitator)

















chr3_+_186648515 0.766 ST6GAL1
ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
chr6_-_31550065 0.765 NM_002341
NM_009588
LTB

lymphotoxin beta (TNF superfamily, member 3)

chr19_-_50432678 0.758 NUP62
nucleoporin 62kDa
chr11_-_2018568 0.757 H19
H19, imprinted maternally expressed transcript (non-protein coding)
chr16_+_30406711 0.750 NM_152652
ZNF48
zinc finger protein 48
chr8_+_86089641 0.743


chr16_+_84733611 0.738 USP10
ubiquitin specific peptidase 10
chr8_+_86089618 0.722 NM_001083588
NM_001951
E2F5

E2F transcription factor 5, p130-binding

chr3_+_32148000 0.713 NM_015141
GPD1L
glycerol-3-phosphate dehydrogenase 1-like
chr11_-_1330891 0.710 NM_019009
TOLLIP
toll interacting protein
chr21_+_45553485 0.710 NM_004649
NM_198155
C21orf33

chromosome 21 open reading frame 33

chr3_+_32148136 0.708 GPD1L
glycerol-3-phosphate dehydrogenase 1-like
chr11_-_33890931 0.704 LMO2
LIM domain only 2 (rhombotin-like 1)
chr9_-_123691442 0.700 NM_001190945
TRAF1
TNF receptor-associated factor 1
chr12_-_49259549 0.697 NM_014470
RND1
Rho family GTPase 1
chr14_-_51135041 0.693 SAV1
salvador homolog 1 (Drosophila)
chr8_+_1712011 0.684 CLN8
ceroid-lipofuscinosis, neuronal 8 (epilepsy, progressive with mental retardation)
chr17_+_40811261 0.676 NM_016437
TUBG2
tubulin, gamma 2
chr9_-_140083034 0.664 NM_013366
ANAPC2
anaphase promoting complex subunit 2
chr11_-_1330883 0.661 TOLLIP
toll interacting protein
chr9_+_135457974 0.661 NM_020064
BARHL1
BarH-like homeobox 1
chr7_+_100450327 0.656 SLC12A9
solute carrier family 12 (potassium/chloride transporters), member 9
chr11_-_64646053 0.641 NM_006795
EHD1
EH-domain containing 1
chr9_-_140082983 0.641 ANAPC2
anaphase promoting complex subunit 2
chr4_+_156587861 0.639 NM_000856
NM_001130682
NM_001130686
NM_001130687
NM_001130683
NM_001130685
GUCY1A3





guanylate cyclase 1, soluble, alpha 3





chr8_-_48650703 0.639 NM_005195
CEBPD
CCAAT/enhancer binding protein (C/EBP), delta
chr21_-_33984455 0.628 C21orf59
chromosome 21 open reading frame 59
chr20_+_30946786 0.627 ASXL1
additional sex combs like 1 (Drosophila)
chr11_-_2019070 0.624 H19
H19, imprinted maternally expressed transcript (non-protein coding)
chr20_-_10654139 0.623 JAG1
jagged 1
chr8_+_120220554 0.620 NM_052886
MAL2
mal, T-cell differentiation protein 2 (gene/pseudogene)
chr1_+_95582827 0.609 NM_152487
TMEM56
transmembrane protein 56
chr4_+_41362750 0.609 NM_001112717
NM_001112718
NM_014988
LIMCH1


LIM and calponin homology domains 1


chr13_+_52586516 0.607 NM_001004127
ALG11
asparagine-linked glycosylation 11, alpha-1,2-mannosyltransferase homolog (yeast)
chr17_+_61554420 0.600 NM_000789
ACE
angiotensin I converting enzyme (peptidyl-dipeptidase A) 1
chr19_-_18391440 0.600


chr19_-_14316980 0.599 NM_001008701
NM_014921
LPHN1

latrophilin 1

chr16_+_84733596 0.598 USP10
ubiquitin specific peptidase 10
chr5_+_68788387 0.596 NM_001205254
OCLN
occludin
chr16_-_77468930 0.587 NM_199355
ADAMTS18
ADAM metallopeptidase with thrombospondin type 1 motif, 18
chr17_-_8702438 0.585 NM_152599
MFSD6L
major facilitator superfamily domain containing 6-like
chr13_-_20357125 0.584 NM_001042414
PSPC1
paraspeckle component 1
chr2_-_192711651 0.583 SDPR
serum deprivation response
chr21_-_27542919 0.577 APP
amyloid beta (A4) precursor protein
chr22_+_30792929 0.568 NM_001204204
NM_012429
NM_033382
SEC14L2


SEC14-like 2 (S. cerevisiae)


chr21_-_33984865 0.567 NM_021254
C21orf59
chromosome 21 open reading frame 59
chr11_-_33891258 0.567 LMO2
LIM domain only 2 (rhombotin-like 1)
chr20_-_10654429 0.566 NM_000214
JAG1
jagged 1
chr1_+_33207343 0.563 NM_020888
KIAA1522
KIAA1522
chr16_+_1728290 0.551 HN1L
hematological and neurological expressed 1-like
chr11_+_59522905 0.548 STX3
syntaxin 3
chr14_+_55034329 0.545 NM_001161576
NM_015589
SAMD4A

sterile alpha motif domain containing 4A

chr6_-_159240367 0.539 EZR
ezrin
chr8_-_494834 0.529 C8orf42
chromosome 8 open reading frame 42
chr1_+_65991357 0.526 NM_001198687
NM_001198688
NM_001198689
LEPR


leptin receptor


chr5_+_31639424 0.526 PDZD2
PDZ domain containing 2
chr11_-_1330840 0.525 TOLLIP
toll interacting protein
chr16_-_11680756 0.516 NM_001136472
NM_001136473
LITAF

lipopolysaccharide-induced TNF factor

chr1_+_12123433 0.514 NM_001243
TNFRSF8
tumor necrosis factor receptor superfamily, member 8
chr1_-_3528058 0.514 NM_001409
MEGF6
multiple EGF-like-domains 6
chr12_-_121734543 0.513 NM_172226
CAMKK2
calcium/calmodulin-dependent protein kinase kinase 2, beta
chr6_+_142622797 0.513 NM_001032394
NM_001032395
NM_020455
NM_198569
GPR126



G protein-coupled receptor 126



chr16_+_84733554 0.513 NM_005153
USP10
ubiquitin specific peptidase 10
chr5_-_88199868 0.509 NM_001131005
NM_001193347
MEF2C

myocyte enhancer factor 2C

chr2_+_173600634 0.507 RAPGEF4
Rap guanine nucleotide exchange factor (GEF) 4
chr6_-_159240433 0.506 NM_001111077
EZR
ezrin
chr15_-_69113213 0.504 ANP32A
acidic (leucine-rich) nuclear phosphoprotein 32 family, member A
chr15_-_69113089 0.501 ANP32A
acidic (leucine-rich) nuclear phosphoprotein 32 family, member A
chr4_-_151936648 0.500 NM_006726
LRBA
LPS-responsive vesicle trafficking, beach and anchor containing
chr11_-_1330808 0.496 TOLLIP
toll interacting protein
chr11_-_694842 0.495 DEAF1
deformed epidermal autoregulatory factor 1 (Drosophila)
chr8_-_141467810 0.494 TRAPPC9
trafficking protein particle complex 9
chr1_-_51425795 0.491 FAF1
Fas (TNFRSF6) associated factor 1
chr2_-_24583291 0.490 NM_006277
NM_019595
NM_147152
ITSN2


intersectin 2


chr6_+_80340971 0.489 NM_031469
SH3BGRL2
SH3 domain binding glutamic acid-rich protein like 2
chr4_-_4291817 0.489 LYAR
Ly1 antibody reactive homolog (mouse)
chr2_-_208634051 0.487 NM_003468
FZD5
frizzled family receptor 5
chr8_+_37654833 0.486 GPR124
G protein-coupled receptor 124
chr4_-_4291731 0.485 NM_001145725
LYAR
Ly1 antibody reactive homolog (mouse)
chr19_+_18391252 0.480


chr5_+_32173481 0.479 LOC153546
uncharacterized LOC153546
chr17_-_43510279 0.478 NM_174919
ARHGAP27
Rho GTPase activating protein 27
chr22_+_31608284 0.478 LIMK2
LIM domain kinase 2
chr1_-_51425740 0.476 FAF1
Fas (TNFRSF6) associated factor 1
chr7_-_37488894 0.474 NM_001206480
ELMO1
engulfment and cell motility 1
chr2_-_235405692 0.473 NM_005737
ARL4C
ADP-ribosylation factor-like 4C
chr13_-_20357081 0.473 PSPC1
paraspeckle component 1
chr15_-_52587851 0.473 NM_018728
MYO5C
myosin VC
chr12_-_121734474 0.471 CAMKK2
calcium/calmodulin-dependent protein kinase kinase 2, beta
chr1_-_27339326 0.469 NM_052943
FAM46B
family with sequence similarity 46, member B
chr17_-_31204187 0.469 MYO1D
myosin ID
chr13_+_114238978 0.469 TFDP1
transcription factor Dp-1
chr6_+_144471631 0.469 NM_003764
STX11
syntaxin 11
chr22_+_31608145 0.468 LIMK2
LIM domain kinase 2
chr11_-_2018446 0.466 H19
H19, imprinted maternally expressed transcript (non-protein coding)
chr4_-_4291889 0.459 NM_017816
LYAR
Ly1 antibody reactive homolog (mouse)
chr19_-_2783225 0.456 SGTA
small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha
chr11_-_71159371 0.456 DHCR7
7-dehydrocholesterol reductase
chr17_+_32597239 0.455 NM_006273
CCL7
chemokine (C-C motif) ligand 7
chr22_+_41777932 0.451 NM_003216
TEF
thyrotrophic embryonic factor
chr4_+_139936938 0.450 NM_012118
CCRN4L
CCR4 carbon catabolite repression 4-like (S. cerevisiae)
chr2_+_28616346 0.450 FOSL2
FOS-like antigen 2
chr8_-_141467853 0.448 NM_001160372
TRAPPC9
trafficking protein particle complex 9
chr19_+_55591759 0.448 NM_017729
EPS8L1
EPS8-like 1
chr22_+_50354428 0.447 PIM3
pim-3 oncogene
chr1_-_51425918 0.446 NM_007051
FAF1
Fas (TNFRSF6) associated factor 1
chr19_-_2783313 0.445 SGTA
small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha
chr5_+_56110899 0.444 NM_005921
MAP3K1
mitogen-activated protein kinase kinase kinase 1
chr4_+_4291923 0.440 NM_145291
ZBTB49
zinc finger and BTB domain containing 49
chr6_+_142623364 0.440 GPR126
G protein-coupled receptor 126
chr14_-_105635114 0.437 NM_002226
NM_145159
JAG2

jagged 2

chr12_+_79439432 0.435 NM_001135806
SYT1
synaptotagmin I
chr6_+_53659738 0.434 NM_018214
LRRC1
leucine rich repeat containing 1
chr14_-_55369163 0.433 NM_000161
NM_001024024
NM_001024070
NM_001024071
GCH1



GTP cyclohydrolase 1



chr1_+_78511588 0.431 NM_017655
GIPC2
GIPC PDZ domain containing family, member 2
chr19_-_7701852 0.427


chr2_+_28616360 0.426 FOSL2
FOS-like antigen 2
chr20_+_61448391 0.424 NM_001853
COL9A3
collagen, type IX, alpha 3
chr13_-_77460432 0.422 NM_138444
KCTD12
potassium channel tetramerisation domain containing 12
chr14_-_76127526 0.421 NM_007176
C14orf1
chromosome 14 open reading frame 1
chr2_+_46524448 0.421 NM_001430
EPAS1
endothelial PAS domain protein 1
chr19_-_50432679 0.420 NUP62
IL4I1
nucleoporin 62kDa
interleukin 4 induced 1
chr22_+_35796294 0.419 MCM5
minichromosome maintenance complex component 5
chr21_+_45553546 0.418 C21orf33
chromosome 21 open reading frame 33
chr14_-_105634708 0.416 JAG2
jagged 2
chr19_-_2783332 0.415 NM_003021
SGTA
small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha
chr20_+_56725982 0.413 NM_178456
C20orf85
chromosome 20 open reading frame 85
chr12_+_122459791 0.413 NM_001024808
NM_020993
BCL7A

B-cell CLL/lymphoma 7A

chr6_+_36646455 0.410 NM_000389
NM_001220778
CDKN1A

cyclin-dependent kinase inhibitor 1A (p21, Cip1)

chr4_+_129732427 0.408 PHF17
PHD finger protein 17
chr6_-_47277640 0.406 TNFRSF21
tumor necrosis factor receptor superfamily, member 21
chr19_-_1132109 0.402 NM_001100122
SBNO2
strawberry notch homolog 2 (Drosophila)
chr11_-_69590170 0.401 NM_002007
FGF4
fibroblast growth factor 4
chr9_+_131185129 0.400 CERCAM
cerebral endothelial cell adhesion molecule
chr7_+_150065968 0.400 REPIN1
replication initiator 1
chr2_+_170590454 0.400 KLHL23
kelch-like 23 (Drosophila)
chr3_-_47517417 0.397 NM_012235
SCAP
SREBF chaperone
chr5_-_32313069 0.394 NM_001040446
MTMR12
myotubularin related protein 12
chr19_+_35739778 0.392 LSR
lipolysis stimulated lipoprotein receptor
chr11_+_65779461 0.384 NM_001323
CST6
cystatin E/M

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.08 1.73e-05 GO:0009987 cellular process
1.16 3.96e-02 GO:0048856 anatomical structure development

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.18 5.49e-20 GO:0005737 cytoplasm
1.10 3.06e-13 GO:0005622 intracellular
1.10 5.94e-12 GO:0044424 intracellular part
1.18 7.70e-11 GO:0044444 cytoplasmic part
1.09 3.08e-06 GO:0043229 intracellular organelle
1.09 3.76e-06 GO:0043226 organelle
1.14 6.93e-05 GO:0044446 intracellular organelle part
1.13 1.07e-04 GO:0044422 organelle part
1.09 1.29e-04 GO:0043231 intracellular membrane-bounded organelle
1.09 1.47e-04 GO:0043227 membrane-bounded organelle
1.23 3.79e-04 GO:0005829 cytosol
1.43 1.64e-03 GO:0030054 cell junction
1.03 2.01e-03 GO:0044464 cell part
1.03 2.11e-03 GO:0005623 cell
1.84 4.71e-03 GO:0005912 adherens junction
1.66 5.30e-03 GO:0016323 basolateral plasma membrane
1.58 5.68e-03 GO:0015629 actin cytoskeleton
1.36 1.14e-02 GO:0031967 organelle envelope
1.59 1.30e-02 GO:0000323 lytic vacuole
1.59 1.30e-02 GO:0005764 lysosome
3.00 1.34e-02 GO:0001725 stress fiber
1.34 2.10e-02 GO:0031975 envelope
1.73 2.11e-02 GO:0070161 anchoring junction
1.19 2.68e-02 GO:0031090 organelle membrane
1.51 3.20e-02 GO:0005773 vacuole
2.71 3.57e-02 GO:0042641 actomyosin
2.80 3.87e-02 GO:0032432 actin filament bundle
1.18 3.88e-02 GO:0044459 plasma membrane part

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.15 1.24e-10 GO:0005515 protein binding
2.09 9.52e-03 GO:0005088 Ras guanyl-nucleotide exchange factor activity
1.79 1.18e-02 GO:0005085 guanyl-nucleotide exchange factor activity